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Dihydroorotate dehydrogenase A


Partner ID 3680
Name Dihydroorotate dehydrogenase A
Synonyms 5694
Gene name pyrDA
General function Nucleotide transport and metabolism
Specific function (S)-dihydroorotate + O(2) = orotate + H(2)O(2)
Gene sequence + ...

ATGCTTAATACAACTTTTGCAAATGCCAAATTCGCTAATCCATTTATGAACGCTTCAGGAGTCCATTGTATGACGATTGAGGATTTAGAAGAATTAAAAGCCTCTCAAGCAGGGGCCTATATCACCAAAAGTTCCACATTAGAAAAAAGAGAAGGTAATCCACTCCCACGTTATGTTGACTTAGAATTAGGGTCAATTAATTCTATGGGTCTGCCTAATTTAGGATTTGATTACTACTTAGACTATGTTTTAAAAAATCAAAAAGAAAATGCTCAAGAAGGGCCAATCTTCTTTTCCATTGCGGGTATGAGTGCAGCAGAAAATATCGCTATGCTCAAGAAAATTCAAGAAAGTGATTTTTCAGGAATTACAGAGTTGAATCTTTCTTGTCCAAATGTTCCTGGTAAACCACAACTTGCTTATGATTTTGAAGCAACTGAAAAGCTCCTAAAAGAAGTTTTTACTTTCTTTACAAAACCGCTAGGTGTCAAACTTCCCCCTTATTTTGACCTTGTACATTTTGATATTATGGCAGAAATCCTCAATCAGTTTCCATTGACTTATGTGAATTCAGTGAATAGTATTGGAAATGGACTTTTTATTGACCCAGAAGCAGAAAGCGTAGTTATTAAGCCTAAAGATGGATTTGGTGGAATTGGTGGAGCTTACATCAAACCAACAGCGCTTGCAAATGTCCGTGCTTTCTATACTCGACTCAAACCTGAAATTCAAATCATTGGAACAGGTGGGATTGAAACAGGACAAGATGCCTTTGAACACCTCTTATGTGGAGCTACAATGCTTCAAATTGGAACAGCTTTACACAAAGAAGGACCTGCAATCTTTGATAGAATCATTAAAGAATTAGAAGAAATAATGAATCAAAAAGGCTATCAATCAATTGCTGATTTCCATGGAAAATTAAAATCATTATAA
Protein sequence + ...

MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYLDYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDFSGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKPLGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLFIDPEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLKPEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEIMNQKGYQSIADFHGKLKSL
GO Classification
component
cell
intracellular
cytoplasm
function
catalytic activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity
dihydroorotate dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
dihydroorotate oxidase activity
process
'de novo' pyrimidine base biosynthesis
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
pyrimidine ribonucleoside monophosphate biosynthesis
nucleotide metabolism
UMP biosynthesis
pyrimidine nucleotide metabolism
pyrimidine nucleotide biosynthesis
pyrimidine nucleoside monophosphate biosynthesis
physiological process
nucleobase metabolism
metabolism
cellular metabolism
pyrimidine base metabolism
pyrimidine base biosynthesis
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02262 Orotic Acid
DB03247 Riboflavin Monophosphate

Associated as Prediction

Id Name
DB00114 Pyridoxal Phosphate
DB00140 Riboflavin
DB00155 L-Citrulline
DB00157 NADH
DB00166 Lipoic Acid
DB00305 Mitomycin
DB00544 Fluorouracil
DB00665 Nilutamide
DB00694 Daunorubicin
DB00698 Nitrofurantoin
DB00865 Benzphetamine
DB00997 Doxorubicin
DB01097 Leflunomide
DB01101 Capecitabine
DB01117 Atovaquone
DB01466 Ethylmorphine
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01650 trans-2-hydroxycinnamic acid
DB01676 Trinitrotoluene
DB01821 L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01997 3-Bromo-7-Nitroindazole
DB02027 N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02060 Cyclohexanone
DB02073 Biliverdine Ix Alpha
DB02077 L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02129 Dihydroorotic Acid
DB02143 N-Isopropyl-N'-Hydroxyguanidine
DB02164 N-Sulfo-Flavin Mononucleotide
DB02209 Pyridoxine-5'-Phosphate
DB02262 Orotic Acid
DB02279 Benzoylformic Acid
DB02303 (5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02379 Beta-D-Glucose
DB02508 Isopentyl Pyrophosphate
DB02613 Decylamine-N,N-Dimethyl-N-Oxide
DB02644 N-Omega-Propyl-L-Arginine
DB02692 (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02727 N-Butyl-N'-Hydroxyguanidine
DB02926 2-Oxo-Glutaric Acid
DB02944 Alpha-D-Mannose
DB02991 S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
DB03014 Heme
DB03048 6-Carboxymethyluracil
DB03064 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline
DB03144 N-Omega-Hydroxy-L-Arginine
DB03147 Flavin-Adenine Dinucleotide
DB03228 5-[Bis-2(Chloro-Ethyl)-Amino]-2,4-Dintro-Benzamide
DB03247 Riboflavin Monophosphate
DB03345 Beta-Mercaptoethanol
DB03350 Cobalt Hexammine Ion
DB03410 4-hydroxycoumarin
DB03419 Uracil
DB03431 Adenosine-5'-Diphosphate
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03480 Brequinar Analog
DB03523 6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid
DB03554 5-Iodouracil
DB03651 2,4,6-Trinitrophenol
DB03698 5-Mercaptoethanol-2-Decenoyl-Coenzyme A
DB03707 S-Ethyl-N-Phenyl-Isothiourea
DB03710 N5-(1-Imino-3-Butenyl)-L-Ornithine
DB03738 Pantothenoylaminoethenethiol
DB03793 Benzoic Acid
DB03801 Lysine Nz-Carboxylic Acid
DB03805 Antiproliferative Agent A771726
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03884 3-Phenylpyruvic Acid
DB03892 5-N-Allyl-Arginine
DB04138 2,4-Dinitro,5-[Bis(2-Bromoethyl)Amino]-N-(2',3'-Dioxopropyl)Benzamide
DB04147 Lauryl Dimethylamine-N-Oxide
DB04223 Nitroarginine
DB04252 N-Carbamoyl-L-Aspartate
DB04253 CB1954
DB04272 Citric Acid
DB04281 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone
DB04345 7,8-dimethylalloxazine
DB04363 Mesobiliverdin Iv Alpha
DB04374 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole
DB04392 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
DB04528 2,4-Dinitrophenol
DB04583 5-(AMINOCARBONYL)-1,1':4',1''-TERPHENYL-3-CARBOXYLICACID
DB06979 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid
DB07060 3-(INDOL-3-YL) LACTATE
DB07373 ANDROSTA-1,4-DIENE-3,17-DIONE
DB07443 (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide
DB07559 (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
DB07561 (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide
DB07646 UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE
DB07837 [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid
DB07907 (2S)-2-HYDROXYOCTANOIC ACID
DB07975 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID
DB07976 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID
DB07977 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID
DB07978 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID
DB08006 N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
DB08008 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08169 (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide
DB08172 (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
DB08191 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
DB08249 3,6,9,12,15-PENTAOXATRICOSAN-1-OL
DB08880 Teriflunomide
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