DT-Web

DB00698 - Nitrofurantoin


Identification
Name Nitrofurantoin
Accession Number DB00698 (APRD00191)
Type small molecule
Description A bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Nitrofurantoin is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria, Salmonella and Shigella. It may be used as an alternative to trimethoprim/sulfamethoxazole for treating urinary tract infections though it may be less effective at eradicating vaginal bacteria. May also be used in females as prophylaxis against recurrent cystitis related to coitus. Nitrofurantoin is highly stable to the development of bacterial resistance, a property thought to be due to its multiplicity of mechanisms of action.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 238.157
Groups approved
Monoisotopic Weight 238.033819322
Pharmacology
Indication May be used as an alternative in the treatment of urinary tract infections. May be used by females pericoitally for prophylaxis against recurrent cystitis related to coitus.
Mechanism of action Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to active reduced reactive intermediates that are thought to modulate and damage ribosomal proteins or other macromolecules, especially DNA, causing inhibition of DNA, RNA, protein, and cell wall synthesis. The overall effect is inhibition of bacterial growth or cell death.
Absorption Readily absorbed in GI tract primarily in small intestine. Enhanced by food or delayed gastric emptying via enhanced dissolution rate of the drug.
Protein binding 20-60% bound to plasma proteins
Biotransformation Partially metabolized in liver to aminofurantoin.
Route of elimination Not Available
Toxicity Acute toxicity may cause vomiting. Adverse effects include nausea and urine discolouration. Rare hepatotoxic and hypersensitivity reactions have occurred. Hemolytic anemia is a risk in patients with G6PD deficiency. Ascending polyneuropathy may occur with prolonged therapy or in patients with low creatinine clearance.
Affected organisms
  • Gram negative and gram positive bacteria
Interactions
Drug Interactions Not Available
Food Interactions
  • Do not take magnesium at the same time.
  • Take with food since it increases bioavailability and reduces irritation.

Targets


Probable pyruvate-flavodoxin oxidoreductase
Name Probable pyruvate-flavodoxin oxidoreductase
Gene Name ydbK
Pharmacological action yes
Actions potentiator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Breeze AS, Obaseiki-Ebor EE: Nitrofuran reductase activity in nitrofurantoin-resistant strains of Escherichia coli K12: some with chromosomally determined resistance and others carrying R-plasmids. J Antimicrob Chemother. 1983 Dec;12(6):543-7. - Pubmed
  • Sisson G, Goodwin A, Raudonikiene A, Hughes NJ, Mukhopadhyay AK, Berg DE, Hoffman PS: Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori. Antimicrob Agents Chemother. 2002 Jul;46(7):2116-23. - Pubmed
DTHybrid score 0.9371
Oxygen-insensitive NADPH nitroreductase
Name Oxygen-insensitive NADPH nitroreductase
Gene Name nfsA
Pharmacological action yes
Actions potentiator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Kutty R, Bennett GN: Biochemical characterization of trinitrotoluene transforming oxygen-insensitive nitroreductases from Clostridium acetobutylicum ATCC 824. Arch Microbiol. 2005 Nov;184(3):158-67. Epub 2005 Nov 10. - Pubmed
  • Lightfoot RT, Shuman D, Ischiropoulos H: Oxygen-insensitive nitroreductases of Escherichia coli do not reduce 3-nitrotyrosine. Free Radic Biol Med. 2000 Apr 1;28(7):1132-6. - Pubmed
DTHybrid score 0.7001
30S ribosomal protein S10
Name 30S ribosomal protein S10
Gene Name rpsJ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9375

Enzymes


NADPH--cytochrome P450 reductase
Name NADPH--cytochrome P450 reductase
Gene Name POR
Actions substrate
References
  • Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD: Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79. Epub 2007 Dec 23. - Pubmed
DTHybrid score 0.5824

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Perez M, Real R, Mendoza G, Merino G, Prieto JG, Alvarez AI: Milk secretion of nitrofurantoin, as a specific BCRP/ABCG2 substrate, in assaf sheep: modulation by isoflavones. J Vet Pharmacol Ther. 2009 Oct;32(5):498-502. - Pubmed
DTHybrid score 0.4012

Predictions


Id Partner name Gene Name Score
6175 30S ribosomal protein S10 rpsJ 0.9375
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.7001
1588 Multidrug resistance protein 1 ABCB1 0.0905
4512 Cytochrome P450 3A4 CYP3A4 0.057
4079 Lipoic acid synthetase, mitochondrial LIAS 0.0397
45 Lipoyltransferase 1, mitochondrial LIPT1 0.0397
105 Sodium-dependent multivitamin transporter SLC5A6 0.038
4757 Cytochrome P450 2C9 CYP2C9 0.0377
6016 Cytochrome P450 2C19 CYP2C19 0.0353
4924 Cytochrome P450 2C8 CYP2C8 0.0349
862 Multidrug resistance-associated protein 1 ABCC1 0.0341
6030 Cytochrome P450 2B6 CYP2B6 0.0328
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0322
4200 Cytochrome P450 1A2 CYP1A2 0.0287
4118 Cytochrome P450 3A5 CYP3A5 0.0269
4119 Cytochrome P450 2D6 CYP2D6 0.0266
6107 Cytochrome P450 3A7 CYP3A7 0.0223
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0218
1898 Cytochrome P450 1B1 CYP1B1 0.0217
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0217
6137 Multidrug resistance-associated protein 6 ABCC6 0.0199
776 Bile salt export pump ABCB11 0.0196
6024 Cytochrome P450 1A1 CYP1A1 0.019
5178 Protein nrdI nrdI 0.0184
5198 Flavodoxin-1 fldA 0.0183
5181 Hypothetical protein yhdA azr 0.0183
5170 Epidermin decarboxylase epiD 0.0183
5201 FMN-binding protein DvMF_2023 0.0183
5179 Probable aromatic acid decarboxylase pad1 0.0183
5175 Hypothetical protein SMU.260 SMU_260 0.0183
5202 Nitroreductase family protein BC_1844 0.0183
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0183
5200 NADH dehydrogenase nox 0.0183
3293 Flavodoxin Not Available 0.0183
4614 Flavodoxin DVU_2680 0.0183
5172 Flavodoxin isiB 0.0183
5173 Flavodoxin isiB 0.0183
5182 Flavodoxin fldA 0.0183
5193 Phenazine biosynthesis protein phzG phzG 0.0183
5131 PhzG phzG 0.0183
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0183
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0183
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0183
5190 Rubredoxin-oxygen oxidoreductase roo 0.0183
5191 Morphinone reductase morB 0.0183
4405 Nitric oxide reductase fprA 0.0183
4037 Hypothetical protein GPX1 0.0183
4297 Hypothetical protein SP_1951 0.0183
4521 Hypothetical protein BC_2969 0.0183
4540 Hypothetical protein TM_1070 0.0183
4555 Hypothetical protein MT1739 0.0183
4569 Hypothetical protein mshD 0.0183
4578 Hypothetical protein PA3270 0.0183
4747 Hypothetical protein PA3967 0.0183
5177 Hypothetical protein TM_0096 0.0183
5194 Hypothetical protein PA1204 0.0183
5240 Hypothetical protein Rv2991 0.0183
5370 Hypothetical protein TM_1158 0.0183
5710 Hypothetical protein Tb927.5.1360 0.0183
4503 NADPH-flavin oxidoreductase frp 0.0182
6148 Multidrug resistance-associated protein 7 ABCC10 0.0182
5189 Trimethylamine dehydrogenase tmd 0.0181
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.018
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0178
817 DNA topoisomerase 2-alpha TOP2A 0.0172
146 Androgen receptor AR 0.017
76 Nitric-oxide synthase, brain NOS1 0.0167
4407 FMN-dependent NADH-azoreductase azoR 0.016
5169 FMN-dependent NADH-azoreductase azoR 0.016
3680 Dihydroorotate dehydrogenase A pyrDA 0.0159
5176 YtnJ moxC 0.0158
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0158
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0158
408 Riboflavin kinase RFK 0.0158
3507 Chorismate synthase aroC 0.0158
5171 Chorismate synthase aroC 0.0158
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0157
131 Synaptic vesicular amine transporter SLC18A2 0.0148
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0148
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0147
2775 Dihydroorotate dehydrogenase pyrD 0.0146
587 Serum albumin ALB 0.0142
654 Flavin reductase BLVRB 0.0141
847 Mu-type opioid receptor OPRM1 0.0139
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0139
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0139
5180 L(+)-mandelate dehydrogenase mdlB 0.0138
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
844 Epidermal growth factor receptor EGFR 0.0134
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0134
3947 Xanthine dehydrogenase/oxidase XDH 0.0132
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0132
713 Sodium-dependent dopamine transporter SLC6A3 0.0131
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0129
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0129
4284 Pentaerythritol tetranitrate reductase onr 0.0126
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0124
6268 Hydroxyacid oxidase 1 HAO1 0.0119
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0114
6144 Solute carrier family 22 member 2 SLC22A2 0.011
556 Alpha-1A adrenergic receptor ADRA1A 0.0107
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0105
318 Alpha-2A adrenergic receptor ADRA2A 0.0103
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0103
504 Mast/stem cell growth factor receptor KIT 0.0098
4192 DNA topoisomerase 2-beta TOP2B 0.0098
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0093
117 Sterol O-acyltransferase 1 SOAT1 0.009
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0089
1729 Solute carrier family 22 member 6 SLC22A6 0.0087
6013 Cytochrome P450 2E1 CYP2E1 0.0085
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0084
2164 Multidrug resistance-associated protein 4 ABCC4 0.0084
33 Cystine/glutamate transporter SLC7A11 0.0084
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
6145 Solute carrier family 22 member 1 SLC22A1 0.0076
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4773 Deoxycytidine kinase DCK 0.0074
6142 Solute carrier family 22 member 8 SLC22A8 0.0073
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
228 Beta platelet-derived growth factor receptor PDGFRB 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0069
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0069
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0068
992 Protein tyrosine kinase 2 beta PTK2B 0.0067
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0064
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0064
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0064
6147 Solute carrier family 22 member 3 SLC22A3 0.0064
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0063
6168 Solute carrier family 22 member 16 SLC22A16 0.0062
1024 Solute carrier family 22 member 11 SLC22A11 0.0058
5718 Cytochrome P450 2A6 CYP2A6 0.0057
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0057
26 Vascular endothelial growth factor receptor 3 FLT4 0.0053
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0053
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
32 Vascular endothelial growth factor receptor 1 FLT1 0.0051
407 Vascular endothelial growth factor receptor 2 KDR 0.0051
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0051
6143 Solute carrier family 22 member 7 SLC22A7 0.0051
136 Estrogen receptor ESR1 0.005
1650 Heme carrier protein 1 SLC46A1 0.005
5787 Angiopoietin-1 receptor TEK 0.0049
20 Prostaglandin G/H synthase 1 PTGS1 0.0049
908 Glutathione S-transferase theta-1 GSTT1 0.0049
29 Tubulin beta-1 chain TUBB1 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
5073 Ferredoxin--NADP reductase petH 0.0046
5076 Ferredoxin--NADP reductase fpr 0.0046
5119 Ferredoxin--NADP reductase petH 0.0046
5121 Ferredoxin--NADP reductase fpr 0.0046
2539 Tubulin alpha-1 chain TUBA4A 0.0045
7 Nitric oxide synthase, inducible NOS2 0.0045
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0043
468 Cytochrome P450 4A11 CYP4A11 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0043
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0042
869 Estrogen receptor beta ESR2 0.0042
6163 Copper-transporting ATPase 2 ATP7B 0.0041
6165 Copper-transporting ATPase 1 ATP7A 0.0041
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0041
904 Glutathione S-transferase P GSTP1 0.004
165 FL cytokine receptor FLT3 0.004
6146 High affinity copper uptake protein 1 SLC31A1 0.004
6220 Aryl hydrocarbon receptor AHR 0.0039
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0039
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0039
6106 Cytochrome P450 2C18 CYP2C18 0.0038
291 Nitric-oxide synthase, endothelial NOS3 0.0037
3811 Cytochrome P450 19A1 CYP19A1 0.0037
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0036
731 HIV-1 protease HIV-1 protease 0.0036
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0035
896 Glutathione S-transferase Mu 1 GSTM1 0.0035
3917 Methylenetetrahydrofolate reductase MTHFR 0.0034
3941 Amine oxidase [flavin-containing] A MAOA 0.0034
3856 Fibroblast growth factor receptor 3 FGFR3 0.0033
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0033
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0032
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0032
70 Type-1 angiotensin II receptor AGTR1 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
118 Organic cation/carnitine transporter 2 SLC22A5 0.0031
293 Gamma-glutamyl hydrolase GGH 0.0031
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0031
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0031
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0031
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0031
5332 MtdA bifunctional protein mtdA 0.0031
5322 Oxidoreductase ydhF ydhF 0.0031
4403 Protein iolS iolS 0.0031
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0031
5330 General stress protein 69 yhdN 0.0031
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0031
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0031
3778 NAD(P) transhydrogenase subunit beta pntB 0.0031
1757 Myeloperoxidase MPO 0.0031
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0031
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
738 Monocarboxylate transporter 1 SLC16A1 0.003
756 Sex hormone-binding globulin SHBG 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
469 Annexin A1 ANXA1 0.003
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
646 Malate dehydrogenase, cytoplasmic MDH1 0.0027
4604 Liver carboxylesterase 1 CES1 0.0027
6136 Multidrug resistance-associated protein 5 ABCC5 0.0027
4582 Putative pteridine reductase 2 ptr2 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0027
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0027
373 Transthyretin TTR 0.0027
2286 Isocitrate dehydrogenase [NADP] icd 0.0027
2302 Isocitrate dehydrogenase [NADP] icd 0.0027
2771 Isocitrate dehydrogenase [NADP] icd 0.0027
5328 Prostaglandin F synthase Tb11.02.2310 0.0027
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0027
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0027
3446 NADP-dependent alcohol dehydrogenase adh 0.0027
2636 Shikimate dehydrogenase aroE 0.0027
3515 Shikimate dehydrogenase aroE 0.0027
729 GDP-L-fucose synthetase TSTA3 0.0027
3463 GDP-L-fucose synthetase fcl 0.0027
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0027
989 L-xylulose reductase DCXR 0.0027
273 Apoptosis regulator Bcl-2 BCL2 0.0026
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0026
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0026
666 NADP-dependent malic enzyme ME1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
290 Prostaglandin G/H synthase 2 PTGS2 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
4531 Putative ketoacyl reductase actIII 0.0025
6297 Prostaglandin reductase 1 PTGR1 0.0025
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0025
2159 Quinone oxidoreductase CRYZ 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
3062 Aspartate-semialdehyde dehydrogenase asd 0.0025
183 Vascular endothelial growth factor A VEGFA 0.0024
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
1124 Sepiapterin reductase SPR 0.0024
2675 Pteridine reductase 1 PTR1 0.0023
4486 Phenol 2-hydroxylase component B pheA2 0.0023
4477 Dihydrolipoyl dehydrogenase lpdV 0.0023
5077 Dihydrolipoyl dehydrogenase Not Available 0.0023
5117 Dihydrolipoyl dehydrogenase lpd 0.0023
4439 Ferredoxin reductase bphA4 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0023
5078 Amine oxidase, flavin-containing PSPTO1126 0.0022
5122 Mersacidin decarboxylase mrsD 0.0022
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0022
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0022
3763 5,10-methylenetetrahydrofolate reductase metF 0.0022
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0022
5094 5,10-methylenetetrahydrofolate reductase metF 0.0022
5083 Cryptochrome DASH cry 0.0022
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0022
526 Thioredoxin reductase trxB 0.0022
3767 Thioredoxin reductase trxB 0.0022
5115 FkbI fkbI 0.0022
3133 UDP-galactopyranose mutase glf 0.0022
5099 UDP-galactopyranose mutase glf 0.0022
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0022
5095 Putidaredoxin reductase camA 0.0022
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0022
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0022
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0022
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0022
1410 Oxidoreductase HSD17B6 0.0022
4725 Oxidoreductase Not Available 0.0022
5124 Oxidoreductase Not Available 0.0022
5081 L-aspartate oxidase nadB 0.0022
5111 Phenylacetone monooxygenase pamO 0.0022
5109 Outer membrane protein p64k or PM-6 m-6 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
3810 Catechol O-methyltransferase COMT 0.0022
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0022
365 Dihydrofolate reductase DHFR 0.0021
2381 Dihydrofolate reductase DFR1 0.0021
2833 Dihydrofolate reductase Not Available 0.0021
2931 Dihydrofolate reductase folA 0.0021
3544 Dihydrofolate reductase folA 0.0021
3682 Dihydrofolate reductase folA 0.0021
6642 Dihydrofolate reductase folA 0.0021
6756 Dihydrofolate reductase dfrA 0.0021
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
3102 Flavohemoprotein hmp 0.002
4969 Flavohemoprotein hmp 0.002
4440 NADH peroxidase npr 0.002
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.002
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.002
327 Glutathione reductase gor 0.002
5110 Glutathione reductase GR2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
5072 N,N-dimethylglycine oxidase dmg 0.002
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.002
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.002
2268 Cholesterol oxidase choB 0.002
2822 Cholesterol oxidase choA 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.002
3594 Deoxyribodipyrimidine photo-lyase phr 0.002
5079 Deoxyribodipyrimidine photo-lyase phrB 0.002
5080 Deoxyribodipyrimidine photo-lyase phr 0.002
2470 Pyruvate oxidase pox5 0.0019
2526 NADPH-ferredoxin reductase fprA fprA 0.0019
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0019
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0019
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0019
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0019
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0019
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
824 Sodium-dependent serotonin transporter SLC6A4 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
126 D-lactate dehydrogenase dld 0.0018
3545 D-lactate dehydrogenase Not Available 0.0018
4510 D-lactate dehydrogenase ldhA 0.0018
605 Fumarate reductase flavoprotein subunit frdA 0.0018
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0018
3673 Fumarate reductase flavoprotein subunit fccA 0.0018
4912 Fumarate reductase flavoprotein subunit ifcA 0.0018
6549 Fumarate reductase flavoprotein subunit frdA 0.0018
725 5-hydroxytryptamine 1D receptor HTR1D 0.0018
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0018
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0018
2893 Glycine oxidase thiO 0.0018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0018
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0018
871 Glucocorticoid receptor NR3C1 0.0018
3809 Estrogen-related receptor gamma ESRRG 0.0018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0018
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
2567 Thymidylate synthase thyX thyX 0.0017
6228 Nuclear receptor coactivator 1 NCOA1 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
1063 Signal transducer and activator of transcription 5B STAT5B 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0017
2823 Trypanothione reductase TPR 0.0017
6241 Nuclear receptor coactivator 2 NCOA2 0.0017
239 Coagulation factor X F10 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
342 P protein [Includes: DNA-directed DNA polymerase P 0.0017
612 P protein [Includes: DNA-directed DNA polymerase P 0.0017
2769 P-hydroxybenzoate hydroxylase pobA 0.0017
2809 P-hydroxybenzoate hydroxylase pobA 0.0017
161 Tubulin beta chain TUBB 0.0016
312 Tubulin beta chain TUB2 0.0016
320 5-hydroxytryptamine 1A receptor HTR1A 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
24 Thymidylate synthase TMP1 0.0016
359 Thymidylate synthase TYMS 0.0016
2626 Thymidylate synthase thyA 0.0016
2729 Thymidylate synthase thyA 0.0016
5352 Thymidylate synthase THYA 0.0016
822 Aldose reductase AKR1B1 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
2380 Monomeric sarcosine oxidase soxA 0.0016
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0015
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0015
6645 D-amino-acid oxidase DAO 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
702 UMP-CMP kinase CMPK1 0.0015
5626 Nucleoside diphosphate kinase B NME2 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
3923 Cholinesterase BCHE 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0013
714 Glutathione reductase, mitochondrial GSR 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1864 RET proto-oncogene RET 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
789 Alpha-1D adrenergic receptor ADRA1D 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
5294 Nucleoside diphosphate kinase A NME1 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
632 Alpha-1B adrenergic receptor ADRA1B 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
3587 Gastrotropin FABP6 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
3939 Amine oxidase [flavin-containing] B MAOB 0.001
5818 Folate receptor alpha FOLR1 0.001
833 Organic cation/carnitine transporter 1 SLC22A4 0.001
6149 Solute carrier family 22 member 10 SLC22A10 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
84 Nuclear receptor 0B1 NR0B1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
467 Delta-type opioid receptor OPRD1 0.001
696 Kappa-type opioid receptor OPRK1 0.001
6014 Cytochrome P450 2A13 CYP2A13 0.0009
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0008
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0008
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0008
6085 Fatty acid-binding protein, intestinal FABP2 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0007
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0006
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0006
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0006
6020 Aldehyde oxidase AOX1 0.0006
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0005
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0005
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0005
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
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