DT-Web

Oxygen-insensitive NADPH nitroreductase


Partner ID 685
Name Oxygen-insensitive NADPH nitroreductase
Synonyms 2026
Gene name nfsA
General function Energy production and conversion
Specific function Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen- insensitive nitroreductase activity in E.coli
Gene sequence + ...

ATGACGCCAACCATTGAACTTATTTGTGGCCATCGCTCCATTCGCCATTTCACTGATGAACCCATTTCCGAAGCGCAGCGTGAGGCGATTATTAACAGCGCCCGTGCGACGTCCAGTTCCAGTTTTTTGCAGTGCAGTAGCATTATTCGCATTACCGACAAAGCGTTACGTGAAGAACTGGTGACGCTGACCGGCGGGCAAAAACACGTAGCGCAAGCGGCGGAGTTCTGGGTGTTCTGTGCCGACTTTAACCGCCATTTACAGATCTGTCCGGATGCTCAGCTCGGCCTGGCGGAACAACTGTTGCTCGGTGTCGTTGATACGGCAATGATGGCGCAGAATGCATTAATCGCAGCGGAATCGCTGGGATTGGGCGGGGTATATATCGGCGGCCTGCGCAATAATATTGAAGCGGTGACGAAACTGCTTAAATTACCGCAGCATGTTCTGCCGCTGTTTGGGCTGTGCCTTGGCTGGCCTGCGGATAATCCGGATCTTAAGCCGCGTTTACCGGCCTCCATTTTGGTGCATGAAAACAGCTATCAACCGCTGGATAAAGGCGCACTGGCGCAGTATGACGAGCAACTGGCGGAATATTACCTCACCCGTGGCAGCAATAATCGCCGGGATACCTGGAGCGATCATATCCGCCGAACAATCATTAAAGAAAGCCGCCCATTTATTCTGGATTATTTGCACAAACAGGGTTGGGCGACGCGCTAA
Protein sequence + ...

MTPTIELICGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALIAAESLGLGGVYIGGLRNNIEAVTKLLKLPQHVLPLFGLCLGWPADNPDLKPRLPASILVHENSYQPLDKGALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR
GO Classification
function
catalytic activity
oxidoreductase activity
process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00698 Nitrofurantoin
DB03247 Riboflavin Monophosphate

Associated as Prediction

Id Name
DB00091 Cyclosporine
DB00114 Pyridoxal Phosphate
DB00140 Riboflavin
DB00155 L-Citrulline
DB00157 NADH
DB00158 Folic Acid
DB00166 Lipoic Acid
DB00175 Pravastatin
DB00213 Pantoprazole
DB00220 Nelfinavir
DB00242 Cladribine
DB00255 Diethylstilbestrol
DB00285 Venlafaxine
DB00286 Conjugated Estrogens
DB00305 Mitomycin
DB00317 Gefitinib
DB00338 Omeprazole
DB00398 Sorafenib
DB00439 Cerivastatin
DB00444 Teniposide
DB00448 Lansoprazole
DB00457 Prazosin
DB00470 Dronabinol
DB00495 Zidovudine
DB00503 Ritonavir
DB00515 Cisplatin
DB00526 Oxaliplatin
DB00530 Erlotinib
DB00541 Vincristine
DB00544 Fluorouracil
DB00549 Zafirlukast
DB00563 Methotrexate
DB00602 Ivermectin
DB00619 Imatinib
DB00624 Testosterone
DB00631 Clofarabine
DB00655 Estrone
DB00661 Verapamil
DB00665 Nilutamide
DB00669 Sumatriptan
DB00675 Tamoxifen
DB00688 Mycophenolate mofetil
DB00694 Daunorubicin
DB00698 Nitrofurantoin
DB00709 Lamivudine
DB00740 Riluzole
DB00741 Hydrocortisone
DB00762 Irinotecan
DB00773 Etoposide
DB00783 Estradiol
DB00795 Sulfasalazine
DB00865 Benzphetamine
DB00921 Buprenorphine
DB00958 Carboplatin
DB00966 Telmisartan
DB00970 Dactinomycin
DB00973 Ezetimibe
DB00997 Doxorubicin
DB01016 Glyburide
DB01030 Topotecan
DB01051 Novobiocin
DB01094 Hesperetin
DB01097 Leflunomide
DB01098 Rosuvastatin
DB01101 Capecitabine
DB01117 Atovaquone
DB01129 Rabeprazole
DB01204 Mitoxantrone
DB01229 Paclitaxel
DB01232 Saquinavir
DB01234 Dexamethasone
DB01248 Docetaxel
DB01254 Dasatinib
DB01268 Sunitinib
DB01466 Ethylmorphine
DB01645 Genistein
DB01650 trans-2-hydroxycinnamic acid
DB01676 Trinitrotoluene
DB01821 L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01997 3-Bromo-7-Nitroindazole
DB02027 N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02060 Cyclohexanone
DB02073 Biliverdine Ix Alpha
DB02077 L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02115 Daidzin
DB02143 N-Isopropyl-N'-Hydroxyguanidine
DB02164 N-Sulfo-Flavin Mononucleotide
DB02209 Pyridoxine-5'-Phosphate
DB02262 Orotic Acid
DB02279 Benzoylformic Acid
DB02303 (5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02379 Beta-D-Glucose
DB02508 Isopentyl Pyrophosphate
DB02613 Decylamine-N,N-Dimethyl-N-Oxide
DB02644 N-Omega-Propyl-L-Arginine
DB02692 (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02727 N-Butyl-N'-Hydroxyguanidine
DB02926 2-Oxo-Glutaric Acid
DB02944 Alpha-D-Mannose
DB02991 S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
DB03014 Heme
DB03048 6-Carboxymethyluracil
DB03064 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline
DB03144 N-Omega-Hydroxy-L-Arginine
DB03147 Flavin-Adenine Dinucleotide
DB03228 5-[Bis-2(Chloro-Ethyl)-Amino]-2,4-Dintro-Benzamide
DB03247 Riboflavin Monophosphate
DB03345 Beta-Mercaptoethanol
DB03350 Cobalt Hexammine Ion
DB03410 4-hydroxycoumarin
DB03419 Uracil
DB03431 Adenosine-5'-Diphosphate
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03467 Naringenin
DB03480 Brequinar Analog
DB03496 Flavopiridol
DB03523 6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid
DB03554 5-Iodouracil
DB03651 2,4,6-Trinitrophenol
DB03698 5-Mercaptoethanol-2-Decenoyl-Coenzyme A
DB03707 S-Ethyl-N-Phenyl-Isothiourea
DB03710 N5-(1-Imino-3-Butenyl)-L-Ornithine
DB03738 Pantothenoylaminoethenethiol
DB03793 Benzoic Acid
DB03805 Antiproliferative Agent A771726
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03884 3-Phenylpyruvic Acid
DB03892 5-N-Allyl-Arginine
DB04138 2,4-Dinitro,5-[Bis(2-Bromoethyl)Amino]-N-(2',3'-Dioxopropyl)Benzamide
DB04147 Lauryl Dimethylamine-N-Oxide
DB04216 Quercetin
DB04223 Nitroarginine
DB04253 CB1954
DB04272 Citric Acid
DB04281 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone
DB04345 7,8-dimethylalloxazine
DB04348 Taurocholic Acid
DB04363 Mesobiliverdin Iv Alpha
DB04374 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole
DB04392 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
DB04528 2,4-Dinitrophenol
DB04540 Cholesterol
DB04583 5-(AMINOCARBONYL)-1,1':4',1''-TERPHENYL-3-CARBOXYLICACID
DB04690 Camptothecin
DB04868 Nilotinib
DB05294 Vandetanib
DB06589 Pazopanib
DB06605 Apixaban
DB06772 Cabazitaxel
DB06979 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid
DB07060 3-(INDOL-3-YL) LACTATE
DB07373 ANDROSTA-1,4-DIENE-3,17-DIONE
DB07443 (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide
DB07559 (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
DB07561 (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide
DB07646 UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE
DB07837 [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid
DB07907 (2S)-2-HYDROXYOCTANOIC ACID
DB07975 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID
DB07976 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID
DB07977 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID
DB07978 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID
DB08006 N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
DB08008 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08169 (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide
DB08172 (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
DB08191 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
DB08249 3,6,9,12,15-PENTAOXATRICOSAN-1-OL
DB08828 Vismodegib
DB08860 Pitavastatin
DB08864 Rilpivirine
DB08880 Teriflunomide
DB08881 Vemurafenib
DB08896 Regorafenib
DB08901 Ponatinib
DB08912 Dabrafenib
DB08916 Afatinib
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