DT-Web: DB00158

Identification

Name

Folic Acid

Accession Number

DB00158 (NUTR00025)

Type

small molecule

Description

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

441.3975

Groups

approved

Monoisotopic Weight

441.139681375

Pharmacology

Indication

For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.

Mechanism of action

Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Absorption

Not Available

Protein binding

Very high to plasma protein

Biotransformation

Hepatic

Route of elimination

Folic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5,6,7,8-tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers.

Toxicity

IPR-MUS LD₅₀ 85 mg/kg,IVN-GPG LD₅₀ 120 mg/kg, IVN-MUS LD₅₀ 239 mg/kg, IVN-RAT LD₅₀ 500 mg/kg, IVN-RBT LD₅₀ 410 mg/kg

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amobarbital	Folic acid decreases the effect of anticonvulsant, amobarbital.
Aprobarbital	Folic acid decreases the effect of anticonvulsant, aprobarbital.
Butabarbital	Folic acid decreases the effect of anticonvulsant, butabarbital.
Butalbital	Folic acid decreases the effect of anticonvulsant, butalbital.
Butethal	Folic acid decreases the effect of anticonvulsant, butethal.
Dihydroquinidine barbiturate	Folic acid decreases the effect of anticonvulsant, dihydroquinidine barbiturate.
Ethotoin	Folic acid decreases the levels of hydantoin
Fosphenytoin	Folic acid decreases the levels of hydantoin
Heptabarbital	Folic acid decreases the effect of anticonvulsant, heptabarbital.
Hexobarbital	Folic acid decreases the effect of anticonvulsant, hexobarbital.
Mephenytoin	Folic acid decreases the levels of hydantoin
Methohexital	Folic acid decreases the effect of anticonvulsant, methohexital.
Methylphenobarbital	Folic acid decreases the effect of anticonvulsant, methylphenobarbital.
Pentobarbital	Folic acid decreases the effect of anticonvulsant, pentobarbital.
Phenobarbital	Folic acid decreases the effect of anticonvulsant, phenobarbital.
Phenytoin	Folic acid may decrease the levels of phenytoin.
Primidone	Folic acid decreases the effect of anticonvulsant, primidone.
Quinidine barbiturate	Folic acid decreases the effect of anticonvulsant, quinidine barbiturate.
Secobarbital	Folic acid decreases the effect of anticonvulsant, secobarbital.
Talbutal	Folic acid decreases the effect of anticonvulsant, talbutal.

Food Interactions

Not Available

Folate receptor beta
Name	Folate receptor beta
Gene Name	FOLR2
Pharmacological action	unknown
Actions	binder
References	Dixit V, Van den Bossche J, Sherman DM, Thompson DH, Andres RP: Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjug Chem. 2006 May-Jun;17(3):603-9. - Pubmed Wlodarczyk BJ, Cabrera RM, Hill DS, Bozinov D, Zhu H, Finnell RH: Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos. Neurotoxicology. 2006 Jul;27(4):547-57. Epub 2006 Apr 18. - Pubmed Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC: Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect. 2006 Oct;114(10):1547-52. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6455
Folate receptor gamma
Name	Folate receptor gamma
Gene Name	FOLR3
Pharmacological action	unknown
Actions	binder
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Shen F, Ross JF, Wang X, Ratnam M: Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry. 1994 Feb 8;33(5):1209-15. - Pubmed Shen F, Wu M, Ross JF, Miller D, Ratnam M: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry. 1995 Apr 25;34(16):5660-5. - Pubmed Prasad PD, Ramamoorthy S, Moe AJ, Smith CH, Leibach FH, Ganapathy V: Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta. 1994 Aug 11;1223(1):71-5. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6454

Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3484
Gamma-glutamyl hydrolase
Name	Gamma-glutamyl hydrolase
Gene Name	GGH
Actions	substrate
References	Schneider E, Ryan TJ: Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10. - Pubmed Eisele LE, Chave KJ, Lehning AC, Ryan TJ: Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim Biophys Acta. 2006 Sep;1764(9):1479-86. Epub 2006 Jul 12. - Pubmed Chen L, Eitenmiller RR: Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8. Epub 2007 Apr 17. - Pubmed
DTHybrid score	0.5995
Methylenetetrahydrofolate reductase
Name	Methylenetetrahydrofolate reductase
Gene Name	MTHFR
Actions	substrate
References	- West AA, Caudill MA: Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29. - Pubmed Kim YI: Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol. 2009 May;5(4):523-42. - Pubmed
DTHybrid score	0.4628

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	substrate
References	Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed
DTHybrid score	0.3992
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions	substrate
References	Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. - Pubmed
DTHybrid score	0.4377
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. - Pubmed Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. - Pubmed
DTHybrid score	0.4424
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD: Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54. - Pubmed
DTHybrid score	0.4117
Heme carrier protein 1
Name	Heme carrier protein 1
Gene Name	SLC46A1
Actions	substrate
References	Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H: Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther. 2007 Aug;322(2):469-76. Epub 2007 May 2. - Pubmed Ashokkumar B, Mohammed ZM, Vaziri ND, Said HM: Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Am J Clin Nutr. 2007 Jul;86(1):159-66. - Pubmed
DTHybrid score	0.7371
Mitochondrial folate transporter/carrier
Name	Mitochondrial folate transporter/carrier
Gene Name	SLC25A32
Actions	substrate
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6304
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998 Nov 6;438(3):321-4. - Pubmed
DTHybrid score	0.4876

Id	Partner name	Gene Name	Score
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1707
4512	Cytochrome P450 3A4	CYP3A4	0.1613
1588	Multidrug resistance protein 1	ABCB1	0.1607
6142	Solute carrier family 22 member 8	SLC22A8	0.1446
365	Dihydrofolate reductase	DHFR	0.1374
2381	Dihydrofolate reductase	DFR1	0.1374
2833	Dihydrofolate reductase	Not Available	0.1374
2931	Dihydrofolate reductase	folA	0.1374
3544	Dihydrofolate reductase	folA	0.1374
3682	Dihydrofolate reductase	folA	0.1374
6642	Dihydrofolate reductase	folA	0.1374
6756	Dihydrofolate reductase	dfrA	0.1374
4757	Cytochrome P450 2C9	CYP2C9	0.1345
862	Multidrug resistance-associated protein 1	ABCC1	0.1206
4200	Cytochrome P450 1A2	CYP1A2	0.1139
6143	Solute carrier family 22 member 7	SLC22A7	0.1057
1024	Solute carrier family 22 member 11	SLC22A11	0.1045
4924	Cytochrome P450 2C8	CYP2C8	0.1033
6016	Cytochrome P450 2C19	CYP2C19	0.1026
587	Serum albumin	ALB	0.1003
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0978
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0922
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0811
6136	Multidrug resistance-associated protein 5	ABCC5	0.0805
4119	Cytochrome P450 2D6	CYP2D6	0.0761
20	Prostaglandin G/H synthase 1	PTGS1	0.0748
290	Prostaglandin G/H synthase 2	PTGS2	0.074
4118	Cytochrome P450 3A5	CYP3A5	0.0732
5818	Folate receptor alpha	FOLR1	0.0712
6148	Multidrug resistance-associated protein 7	ABCC10	0.0708
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0693
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0659
24	Thymidylate synthase	TMP1	0.0654
359	Thymidylate synthase	TYMS	0.0654
2626	Thymidylate synthase	thyA	0.0654
2729	Thymidylate synthase	thyA	0.0654
5352	Thymidylate synthase	THYA	0.0654
5718	Cytochrome P450 2A6	CYP2A6	0.0603
738	Monocarboxylate transporter 1	SLC16A1	0.0576
6024	Cytochrome P450 1A1	CYP1A1	0.0571
6030	Cytochrome P450 2B6	CYP2B6	0.0556
6141	Sodium/bile acid cotransporter	SLC10A1	0.0517
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0507
776	Bile salt export pump	ABCB11	0.0502
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0467
6107	Cytochrome P450 3A7	CYP3A7	0.0464
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0462
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0459
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0457
33	Cystine/glutamate transporter	SLC7A11	0.0446
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0443
6020	Aldehyde oxidase	AOX1	0.0429
6137	Multidrug resistance-associated protein 6	ABCC6	0.0426
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0397
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0386
5698	Riboflavin synthase alpha chain	ribE	0.0379
6145	Solute carrier family 22 member 1	SLC22A1	0.0375
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0353
3685	Catabolite gene activator	crp	0.0351
4655	Adenylate cyclase	cyaC	0.0351
4759	Adenylate cyclase	cyaB2	0.0351
408	Riboflavin kinase	RFK	0.0351
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0346
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0329
6144	Solute carrier family 22 member 2	SLC22A2	0.0311
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0307
809	Methionine synthase	MTR	0.0307
2935	Methionine synthase	metH	0.0307
244	Angiotensin-converting enzyme	ACE	0.0303
4760	Mll3241 protein	mll3241	0.0301
118	Organic cation/carnitine transporter 2	SLC22A5	0.0289
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0287
6167	Organic solute transporter subunit beta	OSTB	0.0281
6166	Organic solute transporter subunit alpha	OSTA	0.0281
275	Arachidonate 5-lipoxygenase	ALOX5	0.0279
6149	Solute carrier family 22 member 10	SLC22A10	0.0276
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0269
1898	Cytochrome P450 1B1	CYP1B1	0.0261
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0252
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0252
5626	Nucleoside diphosphate kinase B	NME2	0.025
3941	Amine oxidase [flavin-containing] A	MAOA	0.0246
654	Flavin reductase	BLVRB	0.0244
3639	Thymidine phosphorylase	deoA	0.0241
3936	Thymidine phosphorylase	TYMP	0.0241
840	Methionine synthase reductase, mitochondrial	MTRR	0.0238
6147	Solute carrier family 22 member 3	SLC22A3	0.0237
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0236
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0229
4226	Uridine phosphorylase 2	UPP2	0.0201
5294	Nucleoside diphosphate kinase A	NME1	0.0201
4604	Liver carboxylesterase 1	CES1	0.02
1181	Alpha-1-acid glycoprotein 1	ORM1	0.02
6106	Cytochrome P450 2C18	CYP2C18	0.0199
817	DNA topoisomerase 2-alpha	TOP2A	0.0192
3947	Xanthine dehydrogenase/oxidase	XDH	0.0184
4225	Uridine phosphorylase 1	UPP1	0.0177
3587	Gastrotropin	FABP6	0.0175
3811	Cytochrome P450 19A1	CYP19A1	0.0174
413	Amidophosphoribosyltransferase	PPAT	0.0172
2515	Amidophosphoribosyltransferase	purF	0.0172
3714	Amidophosphoribosyltransferase	purF	0.0172
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.017
592	Carbonic anhydrase 4	CA4	0.0161
136	Estrogen receptor	ESR1	0.0154
4773	Deoxycytidine kinase	DCK	0.0153
295	Carbonic anhydrase 1	CA1	0.0152
507	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial	MMAB	0.0152
3916	Methylmalonic aciduria and homocystinuria type C protein	MMACHC	0.0152
354	Methylmalonic aciduria type A protein, mitochondrial	MMAA	0.0152
398	Transcobalamin-2	TCN2	0.0152
265	Transcobalamin-1	TCN1	0.0152
376	Amnionless protein	AMN	0.0152
854	Methylmalonyl-CoA mutase, mitochondrial	MUT	0.0152
1224	Cubilin	CUBN	0.0152
6218	Pannexin-1	PANX1	0.0151
468	Cytochrome P450 4A11	CYP4A11	0.015
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0149
633	Penicillin-binding proteins 1A/1B	pbpA	0.0149
117	Sterol O-acyltransferase 1	SOAT1	0.0147
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0147
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6043	Putative G-protein coupled receptor 44	GPR44	0.0144
3810	Catechol O-methyltransferase	COMT	0.0143
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0143
504	Mast/stem cell growth factor receptor	KIT	0.014
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.014
404	DNA gyrase subunit A	gyrA	0.0139
6224	DNA gyrase subunit A	gyrA	0.0139
908	Glutathione S-transferase theta-1	GSTT1	0.0139
1353	DNA topoisomerase 1	TOP1	0.0135
3552	DNA topoisomerase 1	topA	0.0135
6042	Prostaglandin reductase 2	PTGR2	0.0135
844	Epidermal growth factor receptor	EGFR	0.0134
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0131
357	Carbonic anhydrase 2	CA2	0.013
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.013
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.013
645	Penicillin-binding protein 1A	mrcA	0.0128
5805	Penicillin-binding protein 1A	ponA	0.0128
6185	Penicillin-binding protein 1A	mrcA	0.0128
6799	Penicillin-binding protein 1A	pbpA	0.0128
1313	Lactoylglutathione lyase	GLO1	0.0124
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0123
317	Methionine-R-sulfoxide reductase	SEPX1	0.0123
480	Methionine-R-sulfoxide reductase B2	MSRB2	0.0122
3996	Betaine--homocysteine S-methyltransferase 2	BHMT2	0.0122
3921	Methionine adenosyltransferase 2 subunit beta	MAT2B	0.0122
3995	Methionyl-tRNA synthetase, mitochondrial	MARS2	0.0122
600	Methionyl-tRNA synthetase, cytoplasmic	MARS	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0122
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0122
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0122
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0122
400	Coagulation factor IX	F9	0.012
5461	Coagulation factor IX	F9	0.012
2981	Phospholipase A2, membrane associated	PLA2G2A	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0119
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0119
904	Glutathione S-transferase P	GSTP1	0.0118
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0117
338	DNA polymerase	UL30	0.0116
379	DNA polymerase	UL54	0.0116
697	DNA polymerase	ORF28	0.0116
2482	DNA polymerase	43	0.0116
4104	DNA polymerase	BALF5	0.0116
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0116
260	Cytochrome P450 51	ERG11	0.0115
761	Cytochrome P450 51	ERG11	0.0115
3163	Cytochrome P450 51	cyp51	0.0115
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0115
492	Histamine H1 receptor	HRH1	0.0114
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0112
604	Vitamin K-dependent protein Z	PROZ	0.0112
6085	Fatty acid-binding protein, intestinal	FABP2	0.0112
833	Organic cation/carnitine transporter 1	SLC22A4	0.0111
4790	Glycosyltransferase GtfA	gtfA	0.011
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0109
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0109
59	AMT protein	AMT	0.0109
489	Monocarboxylate transporter 2	SLC16A7	0.0108
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0107
6126	Carbonic anhydrase 7	CA7	0.0106
1757	Myeloperoxidase	MPO	0.0106
543	Penicillin-binding protein 1B	mrcB	0.0105
6186	Penicillin-binding protein 1B	ponB	0.0105
6822	Penicillin-binding protein 1b	pbp1b	0.0105
6844	Penicillin-binding protein 1b	pbp1b	0.0105
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0105
26	Vascular endothelial growth factor receptor 3	FLT4	0.0104
723	Cytosolic phospholipase A2	PLA2G4A	0.0102
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0102
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0102
191	Peptide methionine sulfoxide reductase	MSRA	0.0102
824	Sodium-dependent serotonin transporter	SLC6A4	0.0101
3426	Glutamine synthetase	glnA	0.0101
3987	Glutamine synthetase	GLUL	0.0101
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0101
1245	Vitamin K-dependent protein S	PROS1	0.0101
422	Vitamin K-dependent protein C	PROC	0.01
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.01
32	Vascular endothelial growth factor receptor 1	FLT1	0.0099
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0099
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0099
2320	Thymidine kinase, cytosolic	TK1	0.0098
373	Transthyretin	TTR	0.0096
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0095
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0094
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0093
6031	Cytochrome P450 3A43	CYP3A43	0.0093
887	DNA gyrase subunit B	gyrB	0.0093
4150	DNA gyrase subunit B	gyrB	0.0093
6225	DNA gyrase subunit B	gyrB	0.0093
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0092
1405	Thiopurine S-methyltransferase	TPMT	0.0092
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.009
165	FL cytokine receptor	FLT3	0.009
407	Vascular endothelial growth factor receptor 2	KDR	0.009
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0089
702	UMP-CMP kinase	CMPK1	0.0089
2539	Tubulin alpha-1 chain	TUBA4A	0.0089
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0088
2298	Cytochrome P450-cam	camC	0.0088
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0087
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0086
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0086
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0086
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0086
13	Aminomethyltransferase, mitochondrial	AMT	0.0084
6220	Aryl hydrocarbon receptor	AHR	0.0084
2016	Dipeptidase 1	DPEP1	0.0082
896	Glutathione S-transferase Mu 1	GSTM1	0.0082
3884	SHMT2 protein	SHMT2	0.0081
3901	SHMT2 protein	SHMT2	0.0081
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0081
3879	Serine hydroxymethyltransferase 2	Not Available	0.0081
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0081
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0081
1760	Aminopeptidase N	ANPEP	0.0081
6843	Aminopeptidase N	pepN	0.0081
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0081
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.008
1141	Sialidase-1	NEU1	0.008
64	Neuraminidase	NA	0.008
641	Neuraminidase	NA	0.008
2676	Neuraminidase	NA	0.008
3026	Neuraminidase	NA	0.008
3519	Neuraminidase	NA	0.008
6007	Neuraminidase	NA	0.008
798	Osteocalcin	BGLAP	0.008
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.008
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0079
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0079
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0077
6163	Copper-transporting ATPase 2	ATP7B	0.0077
6165	Copper-transporting ATPase 1	ATP7A	0.0077
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0076
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0076
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0076
4120	NADPH--cytochrome P450 reductase	POR	0.0076
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0075
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0074
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0074
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0074
6146	High affinity copper uptake protein 1	SLC31A1	0.0073
3932	Glutathione S-transferase A2	GSTA2	0.0073
22	30S ribosomal protein S4	rpsD	0.0072
6714	30S ribosomal protein S4	rpsD	0.0072
1648	Elastin	ELN	0.0072
115	Penicillin-binding protein 2	mrdA	0.0072
6069	Penicillin-binding protein 2	mrdA	0.0072
6118	Penicillin-binding protein 2	penA	0.0072
6187	Penicillin-binding protein 2	pbpA	0.0072
6686	Penicillin-binding protein 2	pbp2	0.0072
6939	Penicillin-binding protein 2	mrdA	0.0072
7163	Penicillin-binding protein 2	pbpA	0.0072
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0072
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0072
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0071
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0071
161	Tubulin beta chain	TUBB	0.0071
312	Tubulin beta chain	TUB2	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
465	Calmodulin	CALM1	0.0071
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.007
6033	High affinity interleukin-8 receptor A	CXCR1	0.007
16	Adenosine A1 receptor	ADORA1	0.007
369	Coagulation factor VII	F7	0.007
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.007
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0069
239	Coagulation factor X	F10	0.0069
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0069
556	Alpha-1A adrenergic receptor	ADRA1A	0.0069
140	30S ribosomal protein S9	rpsI	0.0068
6719	30S ribosomal protein S9	rpsI	0.0068
6725	30S ribosomal protein S9	rpsI	0.0068
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0068
1198	Serum paraoxonase/arylesterase 1	PON1	0.0068
6223	Penicillin-binding protein 1C	pbpC	0.0068
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0068
992	Protein tyrosine kinase 2 beta	PTK2B	0.0067
1	Peptidoglycan synthetase ftsI	ftsI	0.0066
4155	Peptidoglycan synthetase ftsI	ftsI	0.0066
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0066
2795	Methionine aminopeptidase 2	METAP2	0.0066
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0065
482	Glycine receptor subunit alpha-1	GLRA1	0.0065
4192	DNA topoisomerase 2-beta	TOP2B	0.0064
477	DNA topoisomerase 4 subunit A	parC	0.0064
886	DNA topoisomerase 4 subunit A	parC	0.0064
6226	DNA topoisomerase 4 subunit A	parC	0.0064
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0064
4217	Telomerase reverse transcriptase	TERT	0.0063
29	Tubulin beta-1 chain	TUBB1	0.0063
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0063
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0063
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0063
5482	Sialidase-2	NEU2	0.0062
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0062
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0059
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0059
6171	Solute carrier family 28 member 3	SLC28A3	0.0059
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0059
558	Solute carrier family 12 member 1	SLC12A1	0.0059
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0058
3809	Estrogen-related receptor gamma	ESRRG	0.0058
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0058
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0058
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0058
6151	Monocarboxylate transporter 10	SLC16A10	0.0058
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0058
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0057
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0057
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0057
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0057
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0057
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0057
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0057
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0056
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0056
613	Atrial natriuretic peptide receptor A	NPR1	0.0056
869	Estrogen receptor beta	ESR2	0.0056
705	Glutamate receptor 1	GRIA1	0.0056
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0055
65	Matrix metalloproteinase-9	Not Available	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
517	Alcohol dehydrogenase 1C	ADH1C	0.0054
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0054
3957	Adenosine deaminase	ADA	0.0054
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0053
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0053
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0052
6102	Arylamine N-acetyltransferase 2	NAT2	0.0052
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0052
273	Apoptosis regulator Bcl-2	BCL2	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0051
831	D(2) dopamine receptor	DRD2	0.0051
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.005
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.005
183	Vascular endothelial growth factor A	VEGFA	0.005
320	5-hydroxytryptamine 1A receptor	HTR1A	0.005
5787	Angiopoietin-1 receptor	TEK	0.0049
6014	Cytochrome P450 2A13	CYP2A13	0.0049
1178	Adenosine A2a receptor	ADORA2A	0.0048
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0047
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0047
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
6131	Carbonic anhydrase 14	CA14	0.0045
23	D(1A) dopamine receptor	DRD1	0.0045
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
3923	Cholinesterase	BCHE	0.0045
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0045
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0045
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0045
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
731	HIV-1 protease	HIV-1 protease	0.0044
444	Alcohol dehydrogenase 1B	ADH1B	0.0043
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0043
54	Prothrombin	F2	0.0043
2230	Catalase	CAT	0.0043
3249	Catalase	katA	0.0043
3625	Catalase	katA	0.0043
4539	Catalase	katA	0.0043
4941	Catalase	katB	0.0043
70	Type-1 angiotensin II receptor	AGTR1	0.0042
6122	Carbonic anhydrase 3	CA3	0.0042
3007	Carbonic anhydrase 12	CA12	0.0041
2391	Ferrochelatase	hemH	0.0041
6502	Ferrochelatase	DKFZp686P18130	0.0041
1591	Ferrochelatase, mitochondrial	FECH	0.0041
4205	Carbonic anhydrase 9	CA9	0.0041
251	Alcohol dehydrogenase 1A	ADH1A	0.0041
777	Tumor necrosis factor	TNF	0.0041
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.004
274	Muscarinic acetylcholine receptor M5	CHRM5	0.004
341	5-hydroxytryptamine 3 receptor	HTR3A	0.004
632	Alpha-1B adrenergic receptor	ADRA1B	0.004
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.004
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.004
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.004
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0039
3823	Cytokine receptor common gamma chain	IL2RG	0.0039
823	Fibroblast growth factor receptor 2	FGFR2	0.0039
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0039
2021	Thrombomodulin	THBD	0.0038
1192	Sulfotransferase 1A1	SULT1A1	0.0037
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0037
5353	Glutamate decarboxylase alpha	gadA	0.0037
789	Alpha-1D adrenergic receptor	ADRA1D	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0037
469	Annexin A1	ANXA1	0.0036
7	Nitric oxide synthase, inducible	NOS2	0.0036
1010	Cytochrome P450 51A1	CYP51A1	0.0036
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0036
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0036
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0036
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0036
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0036
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0036
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0036
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0036
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0036
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0036
6559	Cytochrome c oxidase subunit 2	ctaC	0.0036
6669	Cytochrome c oxidase subunit 2	ctaC	0.0036
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0036
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0036
6558	Cytochrome c oxidase subunit 1	ctaD	0.0036
3939	Amine oxidase [flavin-containing] B	MAOB	0.0035
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0035
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0035
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0035
713	Sodium-dependent dopamine transporter	SLC6A3	0.0034
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0034
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0034
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0034
6168	Solute carrier family 22 member 16	SLC22A16	0.0034
724	Interleukin-2 receptor alpha chain	IL2RA	0.0034
717	Interleukin-2 receptor subunit beta	IL2RB	0.0034
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0034
2178	Metabotropic glutamate receptor 5	GRM5	0.0034
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0034
811	Translocator protein	TSPO	0.0034
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0034
3856	Fibroblast growth factor receptor 3	FGFR3	0.0033
4116	Dihydropteroate synthetase	Not Available	0.0033
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0033
4122	Histone deacetylase 2	HDAC2	0.0033
2540	Choloylglycine hydrolase	cbh	0.0033
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0033
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0033
921	Glutamate receptor 2	GRIA2	0.0032
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0032
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0032
461	Glycine receptor subunit alpha-3	GLRA3	0.0032
318	Alpha-2A adrenergic receptor	ADRA2A	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0031
94	5-hydroxytryptamine 4 receptor	HTR4	0.0031
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0031
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0031
6501	Fatty acid-binding protein, liver	FABP1	0.0031
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0031
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0031
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0031
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0031
380	Cytochrome P450 17A1	CYP17A1	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0031
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0031
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0031
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.003
756	Sex hormone-binding globulin	SHBG	0.003
5923	Microtubule-associated protein tau	MAPT	0.003
5924	Microtubule-associated protein 4	MAP4	0.003
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.003
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.003
4034	Glutaredoxin-1	GLRX	0.003
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.003
1928	Leukotriene C4 synthase	LTC4S	0.0029
4037	Hypothetical protein	GPX1	0.0029
4297	Hypothetical protein	SP_1951	0.0029
4521	Hypothetical protein	BC_2969	0.0029
4540	Hypothetical protein	TM_1070	0.0029
4555	Hypothetical protein	MT1739	0.0029
4569	Hypothetical protein	mshD	0.0029
4578	Hypothetical protein	PA3270	0.0029
4747	Hypothetical protein	PA3967	0.0029
5177	Hypothetical protein	TM_0096	0.0029
5194	Hypothetical protein	PA1204	0.0029
5240	Hypothetical protein	Rv2991	0.0029
5370	Hypothetical protein	TM_1158	0.0029
5710	Hypothetical protein	Tb927.5.1360	0.0029
907	Glutathione peroxidase 2	GPX2	0.0029
4029	Microsomal glutathione S-transferase 3	MGST3	0.0029
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0029
4032	Microsomal glutathione S-transferase 1	MGST1	0.0029
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0029
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0029
910	Epididymal secretory glutathione peroxidase	GPX5	0.0029
4036	Glutathione peroxidase 6	GPX6	0.0029
903	Glutathione S-transferase A5	GSTA5	0.0029
911	Glutathione peroxidase 3	GPX3	0.0029
4040	Glutathione peroxidase 7	GPX7	0.0029
906	Glutathione peroxidase 1	GPX1	0.0029
4033	S-formylglutathione hydrolase	ESD	0.0029
4035	Glutathione S-transferase Mu 5	GSTM5	0.0029
900	Glutathione S-transferase A4	GSTA4	0.0029
4042	Glutathione transferase omega-2	GSTO2	0.0029
4038	Glutathione peroxidase 4	GPX4	0.0029
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0029
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0029
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0029
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0029
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0029
153	Dopamine beta-hydroxylase	DBH	0.0029
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
1253	Interferon gamma	IFNG	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1867	Major prion protein	PRNP	0.0028
390	Adenosine A3 receptor	ADORA3	0.0028
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0028
1852	Microtubule-associated protein 2	MAP2	0.0028
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0027
1025	Aquaporin-1	AQP1	0.0027
106	Cannabinoid receptor 2	CNR2	0.0027
3404	Exotoxin A	eta	0.0027
1618	High affinity nerve growth factor receptor	NTRK1	0.0027
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0027
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0027
897	Glutathione S-transferase kappa 1	GSTK1	0.0026
898	Glutathione S-transferase A3	GSTA3	0.0026
146	Androgen receptor	AR	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
909	Maleylacetoacetate isomerase	GSTZ1	0.0026
6500	Phospholipase A2	PLA2G1B	0.0026
68	Cannabinoid receptor 1	CNR1	0.0026
1792	Tissue-type plasminogen activator	PLAT	0.0026
638	D(3) dopamine receptor	DRD3	0.0026
905	Glutathione transferase omega-1	GSTO1	0.0026
899	Glutathione S-transferase Mu 3	GSTM3	0.0026
936	Ephrin type-A receptor 2	EPHA2	0.0026
891	Dihydropteroate synthase	folP	0.0025
5359	Dihydropteroate synthase	folP	0.0025
7175	Dihydropteroate synthase	sulI	0.0025
130	Prostacyclin synthase	PTGIS	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
4041	Microsomal glutathione S-transferase 2	MGST2	0.0025
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
291	Nitric-oxide synthase, endothelial	NOS3	0.0025
6207	30S ribosomal protein S14	rpsN	0.0024
6209	30S ribosomal protein S19	rpsS	0.0024
6712	30S ribosomal protein S19	rpsS	0.0024
6726	30S ribosomal protein S19	rpsS	0.0024
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0024
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0024
473	L-lactate dehydrogenase A chain	LDHA	0.0024
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0024
2165	Glutathione S-transferase Mu 2	GSTM2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0023
207	Glutathione synthetase	GSS	0.0023
5269	Glutathione synthetase	gshB	0.0023
76	Nitric-oxide synthase, brain	NOS1	0.0023
358	Cystathionine beta-synthase	CBS	0.0023
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
6182	Cytochrome P450 2J2	CYP2J2	0.0022
871	Glucocorticoid receptor	NR3C1	0.0022
901	Glutathione S-transferase Mu 4	GSTM4	0.0022
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2290	ADP-ribosyl cyclase 2	BST1	0.0022
1196	Complement decay-accelerating factor	CD55	0.0021
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0021
527	Prostacyclin receptor	PTGIR	0.0021
3937	Fatty-acid amide hydrolase	FAAH	0.0021
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
518	Peroxidase/catalase T	katG	0.002
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.002
1058	Cell division protein kinase 5	CDK5	0.002
997	Protein kinase C beta type	PRKCB	0.002
4031	Glutathione S-transferase A1	GSTA1	0.002
1714	Mitogen-activated protein kinase 3	MAPK3	0.0019
867	Penicillin-binding protein 3	pbpC	0.0019
6119	Penicillin-binding protein 3	pbp3	0.0019
7154	Penicillin-binding protein 3	pbp3	0.0019
7157	Penicillin-binding protein 3	LMHCC_2184	0.0019
7162	Penicillin-binding protein 3	pbpB	0.0019
7172	Penicillin-binding protein 3	pbp3	0.0019
1275	Estrogen sulfotransferase	SULT1E1	0.0019
563	Thyroid peroxidase	TPO	0.0019
714	Glutathione reductase, mitochondrial	GSR	0.0019
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
6138	Multidrug resistance protein 3	ABCB4	0.0019
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0019
847	Mu-type opioid receptor	OPRM1	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0019
634	Squalene monooxygenase	SQLE	0.0019
7196	Squalene monooxygenase	ERG1	0.0019
6837	Serine/threonine-protein kinase 17B	STK17B	0.0018
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0018
1970	Protein kinase C alpha type	PRKCA	0.0018
1050	Bile salt sulfotransferase	SULT2A1	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0018
53	Solute carrier family 12 member 5	SLC12A5	0.0018
663	Solute carrier family 12 member 4	SLC12A4	0.0018
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
84	Nuclear receptor 0B1	NR0B1	0.0017
2216	Fibroblast growth factor receptor 4	FGFR4	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
6228	Nuclear receptor coactivator 1	NCOA1	0.0017
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0017
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
6241	Nuclear receptor coactivator 2	NCOA2	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0017
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0017
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0017
310	Solute carrier family 12 member 2	SLC12A2	0.0017
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0016
432	D(4) dopamine receptor	DRD4	0.0016
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0016
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0016
459	Retinoic acid receptor RXR-alpha	RXRA	0.0016
3601	Dihydropteroate synthase 1	folP1	0.0016
3807	Dihydropteroate synthase 1	folP1	0.0016
3808	Dihydropteroate synthase 2	folP2	0.0016
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0015
378	Alpha-2C adrenergic receptor	ADRA2C	0.0015
494	Caspase-1	CASP1	0.0015
122	P2Y purinoceptor 12	P2RY12	0.0015
3913	Glutamic acid decarboxylase	GAD65	0.0015
1507	Cytochrome c	CYCS	0.0015
484	Tyrosine-protein kinase ABL2	ABL2	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
5798	Mitogen-activated protein kinase 11	MAPK11	0.0014
3760	Penicillin-binding protein 5 precursor	dacA	0.0014
1483	Membrane copper amine oxidase	AOC3	0.0014
319	Opioid receptor, sigma 1	OPRS1	0.0014
2236	Casein kinase II subunit alpha	CSNK2A1	0.0014
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
822	Aldose reductase	AKR1B1	0.0014
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0014
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0013
467	Delta-type opioid receptor	OPRD1	0.0013
696	Kappa-type opioid receptor	OPRK1	0.0013
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0013
6824	Tyrosine-protein kinase Lyn	LYN	0.0013
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0013
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0013
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0013
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
976	Platelet glycoprotein IX	GP9	0.0013
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0013
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0013
2077	Caspase-3	CASP3	0.0013
1864	RET proto-oncogene	RET	0.0013
1374	Natriuretic peptides B	NPPB	0.0013
1827	Gap junction alpha-1 protein	GJA1	0.0013
1908	Vascular cell adhesion protein 1	VCAM1	0.0013
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0013
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0013
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0013
760	Fibroblast growth factor 1	FGF1	0.0013
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0012
819	Penicillin-binding protein 4	dacB	0.0012
814	Ryanodine receptor 1	RYR1	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
952	Dipeptidyl peptidase 4	DPP4	0.0012
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0012
6432	Transporter	snf	0.0012
124	Histamine H2 receptor	HRH2	0.0012
716	5-hydroxytryptamine 7 receptor	HTR7	0.0012
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0012
174	Sigma 1-type opioid receptor	SIGMAR1	0.0012
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0011
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0011
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0011
268	Adenosine A2b receptor	ADORA2B	0.0011
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0011
820	Glycine receptor subunit alpha-2	GLRA2	0.0011
2240	Cell division protein kinase 2	CDK2	0.0011
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
193	Beta-1 adrenergic receptor	ADRB1	0.001
766	Beta-2 adrenergic receptor	ADRB2	0.001
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.001
1039	Histone deacetylase 9	HDAC9	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0009
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0009
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0009
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0009
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0009
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0009
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
3221	Cytochrome c4	cc4	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
751	Potassium channel subfamily K member 6	KCNK6	0.0008
629	Alpha-2B adrenergic receptor	ADRA2B	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
4311	tRNA	TRDMT1	0.0008
4325	tRNA	trmD	0.0008
4328	tRNA	trmD	0.0008
6459	Glycodelin	PAEP	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0008
172	Potassium channel subfamily K member 1	KCNK1	0.0008
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0008
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0007
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0007
2802	Endoglucanase G	celCCG	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0007
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0007
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0007
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0007
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
2207	Rhodopsin	RHO	0.0006
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0006
163	D(1B) dopamine receptor	DRD5	0.0006
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0005
164	Histamine H4 receptor	HRH4	0.0005
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0005
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0004

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00158 - Folic Acid

Targets

Enzymes

Transporters

Predictions