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Adenylate cyclase


Partner ID 4655
Name Adenylate cyclase
Synonyms 909
Gene name cyaC
General function Involved in phosphorus-oxygen lyase activity
Specific function Not Available
Gene sequence + ...

ATGAGTTCCCCCAACAGAAAATTGAAGCCCACCATATTAGTGGTTGATGATGAGCCAGATAATTTAGATCTGCTATACCGGACTTTCCATCGGGAATTTAAAGTTCTCAAAGCCGAAAGTGGGCCGGCTGCATTGAAGATCTTAGAAGAGGTGGGGGAAGTAGCAGTAATTATCTCTGATCAGCGGATGCCCTATATGAGTGGCACAGAGTTTCTCAGTTTGACCGCGACTCAATATCCCGATTCGATCCGCATTATCCTCACTGGTTATACGGATGTTGAAGACCTGGTAGAGGCAATTAACTCCGGTAAGGTGTTTAAATATGTCACTAAACCTTGGAAATCTGATGAACTCAAGGCGATCGTTCAGCAAGGTTTAGAAACTCATAATGTCCTGAAATCTCGCACAGAGGAACTACGCCTAGCACAAAAACAGGAATCGTTACTTTATGAAGTGACAAGTACCATTCGCGCCTGTCCTAATTCCCAGGAAATGTTGCAGCGCATAGTTGAAACAGTGGGTAAAATGTTTGAGGTGAGCTATTGTCTGCTGCGTTCATTCGGTGTGGGTTCAGACCTGATAGGGCTGGGGGCTGGAGTCAGCCCTACCAAACAGGATATCACTGCTACACAAGGGAAGGAGTGGTTCGCATACTTAGCGGAAGGTCAGAATCATCAAAATTCCACGACAGACAACATCAGCGTTATCAATAATAATGATCTGGAATTGAGATCCCTGGTTTGGGAAACTACGGAAGTAATGATTCTTTCGGAAGGTTTGGGAAATGATATTTCTGACCACGATGGACCAGAATGGCAGCAGCGACGAGACGTTTACCAACGTGCAGATATTCGCTCCAGTTTGATAGTGCCTCTGTATTACCGTCAGGAATTGTTGGCGGTTTTGGCGCTGCACCACACGGGATCGCCCCGTAATTGGCATGAACATGAAGTGCAGTTAGCTGCGGGTGTAGCAGATCAGGCGGCTTTGGCATTGTCTCAGGTGCGCGCATACGAGCAGGTGCGAGAATTGGCTCGTAGGGAAGCGCTGGTTAATACGATTACCAATGCTATTCGGTCTAGTCTTGACCCTCAGAAAATTTTTGCGGCTATCACTGAGCAATTGGGGGAGGCTTTGGAGGTTGATGGCTGTGCTTTGTCTCTCTGGAGTCCGGGAGATGAATATATGCAGTGTGTAGGCCTTTATAATGCGGCGATTAAAGAAACAGTAGTAGAGACTAGACCGGCGGCTTTGTCTGAACCTGATACCAGCACGACGACGAATTTGCCCCTATTGGGGGTAGAAACTAATCAATCCATTGAGTCCGATCAGTCCGATGATTTGCCTCAGTCGGCGGCTCCTATTAGTGGCAACCCGGTGCTTCAGGAATTGATTAGAACTCGCGCTCCGGTGGCGATCGCTGATATCGAACAGCGACCAGACTCGATGGTGATGTTGCCTTTGCGATCGCCTTCTAAGGCTCTATTGGTTGTGCCACTATTGCTCGATGGTGATATTATTGGCAGCATATCCCTACGCCAAAATCACCAAGTTCGCCATTGGCAACCCTCCGAAATTGATATGGTCCTGTTGGTGGCAGCCCAAGCCGCTTTGGCGGTACAGCAGGCTCGTCTATACCAAAAAACACGCCAGCAAGCAGAACGCCTATTAGAAGCCGACCGCCTCAAAACTGAGTTTTTTCAAAATGTCTCCCACGAGTTTCGCACCCCTTTGACTTTGATGATAGGTCCTTTGGAAACGGTGGTTAATCAACAGCAGGATCTGTCATTAGACCAAGCGAAAATTGCTCTGCGTAACTCCAGGCGACTATTGCGCTTGGTTAATCAATTATTGGATTTGCAACGGTTTGATGCGGGACGAATGCAGCCCAGTTTTCGCCCCTGTGACCTGGTGGAGTTTTGTCAGCAAACGGTGGAATCATTTAAGTCTTATTGCGATCGCAAACAAATTAATCTAGTTACCAATTTACAGAGTTGCCCCCAACTTTATCTTGATCTGGAAAGGTTTGATAAAGTCCTTTACAATTTGCTCTCTAATGCCATGAAGTTTACCCCCACCGATGGCACTATTACCGTTAGTCTCCAGCCCGAAGGGAATTATTGCCGTCTTATGGTCAAAGATACCGGGATTGGTATTAAACAAGAACAACTCCCCCATTTATTTGAACGCTTCCGACAAGCTGAAGGTTCAGCCAATCGCTCCTTTGAGGGGAGTGGCTTGGGATTGGCTCTGGTTAAAGAGTTGGTCGAACTCCATCATGGTCGCATTACTGTAGAGTCTGAGTATGGTCAGGGAACTACATTTACCGTCTGGCTACAAATGGGGAATCTTCATCTACCACCCTCGCCTCTCCTTGATGTTCCCGCTGAGTTTGATGCACGTCGAGCAGCCGTAGAATTGGCTGATGTGGAGGTCGATTTACCAGATGTACAAATTGACGACATAAATCTGCCGGAGGTTTTGGTTGCTGACGGTTCGGCTTCCCTCACGGACCACGGACAGTTGGGGTCTAATACTGTCCTGGTGGTGGATGATAACCCCGATTTGCGCCGCTATGTGTCGATGATGTTGCAAAATGCCGGATTTAATGCGGTTTTGGCTAAGAATGGCGCTGATGGTTTTAACAAGGCTCAGACTTATCATCCTGATGTGATTGTTACTGATTTGATGATGCCCCAGGTGTCTGGGTTGGAGTTGATTCGCATGATTCGCTCCTCACCTGAACTTAGGGGAACTCCAATTATTTTGTTGACTGCTAAGGCTGATGAGGATACCCGCATCGAAGGGGTTGAGCGCGGCGCTGATGCCTATGTTTCTAAGCCTTTTAATGACCGGGAGTTGATAGCTGAGGTCAGGAATTTACAGGCCCTCAAGGCAGAGGAACGACGGGTAGCCCATTTGAATAAGTATCTGACTGAATCAGTATTGCGACGGTTTTTGCCGGAGTCTATGGTCAAAAAGGCGGCGGCGGGGGACTTGACTCTGGATTTGCGCCCGGAACCGAGGCTGATTACCATTTTATTTAGTGATATTGTCGGTTTTACTCGGATGTCTAATGCTCTACAGTCTCAGGGGGTGGCGGAATTGCTTAATGAGTATTTGGGAGAAATGACTCGGGCGGTTTTTGAGAATCAGGGGACTGTTGACAAGTTTGTAGGAGATGCGATTATGGCTTTGTATGGAGCCCCGGAGGAGATGAGCCCCTCTGAACAAGTCCGACGCGCGATCGCTACGGCTAGACAAATGTTGGTGGCTCTCGAAAAACTTAACCAGGGTTGGCAGGAACGAGGTTTGGTGGGCCGTAATGAGGTTCCTCCGGTGCGGTTCCGCTGTGGGATTCACCAGGGTATGGCTGTGGTGGGGTTGTTTGGTTCCCAAGAGCGATCGGATTTTACGGCGATCGGTCCTTCGGTTAATATTGCTGCCCGTCTTCAGGAGGCTACTGCCCCCAACAGCATTATGGTATCCGCTATGGTGGCTCAGTATGTCCCCGATGAGGAGATTATTAAGCGCGAATTTCTCGAACTTAAAGGCATTGATGAGCCGGTAATGACTTGTGTGATTAACCCAAATATGCTGAATCAGTAA
Protein sequence + ...

MSSPNRKLKPTILVVDDEPDNLDLLYRTFHREFKVLKAESGPAALKILEEVGEVAVIISDQRMPYMSGTEFLSLTATQYPDSIRIILTGYTDVEDLVEAINSGKVFKYVTKPWKSDELKAIVQQGLETHNVLKSRTEELRLAQKQESLLYEVTSTIRACPNSQEMLQRIVETVGKMFEVSYCLLRSFGVGSDLIGLGAGVSPTKQDITATQGKEWFAYLAEGQNHQNSTTDNISVINNNDLELRSLVWETTEVMILSEGLGNDISDHDGPEWQQRRDVYQRADIRSSLIVPLYYRQELLAVLALHHTGSPRNWHEHEVQLAAGVADQAALALSQVRAYEQVRELARREALVNTITNAIRSSLDPQKIFAAITEQLGEALEVDGCALSLWSPGDEYMQCVGLYNAAIKETVVETRPAALSEPDTSTTTNLPLLGVETNQSIESDQSDDLPQSAAPISGNPVLQELIRTRAPVAIADIEQRPDSMVMLPLRSPSKALLVVPLLLDGDIIGSISLRQNHQVRHWQPSEIDMVLLVAAQAALAVQQARLYQKTRQQAERLLEADRLKTEFFQNVSHEFRTPLTLMIGPLETVVNQQQDLSLDQAKIALRNSRRLLRLVNQLLDLQRFDAGRMQPSFRPCDLVEFCQQTVESFKSYCDRKQINLVTNLQSCPQLYLDLERFDKVLYNLLSNAMKFTPTDGTITVSLQPEGNYCRLMVKDTGIGIKQEQLPHLFERFRQAEGSANRSFEGSGLGLALVKELVELHHGRITVESEYGQGTTFTVWLQMGNLHLPPSPLLDVPAEFDARRAAVELADVEVDLPDVQIDDINLPEVLVADGSASLTDHGQLGSNTVLVVDDNPDLRRYVSMMLQNAGFNAVLAKNGADGFNKAQTYHPDVIVTDLMMPQVSGLELIRMIRSSPELRGTPIILLTAKADEDTRIEGVERGADAYVSKPFNDRELIAEVRNLQALKAEERRVAHLNKYLTESVLRRFLPESMVKKAAAGDLTLDLRPEPRLITILFSDIVGFTRMSNALQSQGVAELLNEYLGEMTRAVFENQGTVDKFVGDAIMALYGAPEEMSPSEQVRRAIATARQMLVALEKLNQGWQERGLVGRNEVPPVRFRCGIHQGMAVVGLFGSQERSDFTAIGPSVNIAARLQEATAPNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPNMLNQ
GO Classification
component
cell
membrane
function
ATP binding
two-component response regulator activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
purine nucleotide binding
protein histidine kinase activity
adenyl nucleotide binding
two-component sensor molecule activity
binding
transferase activity
nucleic acid binding
phosphorus-oxygen lyase activity
nucleotide binding
catalytic activity
signal transducer activity
DNA binding
lyase activity
process
regulation of cellular metabolism
biopolymer metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
biopolymer modification
regulation of transcription
protein modification
regulation of transcription, DNA-dependent
intracellular signaling cascade
protein amino acid phosphorylation
two-component signal transduction system (phosphorelay)
physiological process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleotide metabolism
nucleotide biosynthesis
cyclic nucleotide biosynthesis
metabolism
cellular process
regulation of biological process
phosphorus metabolism
cellular metabolism
cell communication
regulation of physiological process
phosphate metabolism
signal transduction
regulation of metabolism
phosphorylation
macromolecule metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02355 Adenosine-5'-Rp-Alpha-Thio-Triphosphate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB07706 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE

Associated as Prediction

Id Name
DB00091 Cyclosporine
DB00139 Succinic acid
DB00140 Riboflavin
DB00143 Glutathione
DB00158 Folic Acid
DB00168 Aspartame
DB00175 Pravastatin
DB00181 Baclofen
DB00198 Oseltamivir
DB00199 Erythromycin
DB00203 Sildenafil
DB00229 Cefotiam
DB00254 Doxycycline
DB00277 Theophylline
DB00279 Liothyronine
DB00286 Conjugated Estrogens
DB00300 Tenofovir
DB00311 Ethoxzolamide
DB00313 Valproic Acid
DB00316 Acetaminophen
DB00319 Piperacillin
DB00328 Indomethacin
DB00345 Aminohippurate
DB00352 Thioguanine
DB00365 Grepafloxacin
DB00369 Cidofovir
DB00390 Digoxin
DB00398 Sorafenib
DB00432 Trifluridine
DB00437 Allopurinol
DB00438 Ceftazidime
DB00446 Chloramphenicol
DB00456 Cefalotin
DB00469 Tenoxicam
DB00482 Celecoxib
DB00493 Cefotaxime
DB00495 Zidovudine
DB00500 Tolmetin
DB00501 Cimetidine
DB00512 Vancomycin
DB00515 Cisplatin
DB00520 Caspofungin
DB00529 Foscarnet
DB00533 Rofecoxib
DB00536 Guanidine
DB00544 Fluorouracil
DB00554 Piroxicam
DB00563 Methotrexate
DB00567 Cephalexin
DB00577 Valaciclovir
DB00578 Carbenicillin
DB00583 L-Carnitine
DB00584 Enalapril
DB00586 Diclofenac
DB00595 Oxytetracycline
DB00605 Sulindac
DB00606 Cyclothiazide
DB00607 Nafcillin
DB00624 Testosterone
DB00649 Stavudine
DB00650 Leucovorin
DB00661 Verapamil
DB00672 Chlorpropamide
DB00678 Losartan
DB00693 Fluorescein
DB00695 Furosemide
DB00703 Methazolamide
DB00709 Lamivudine
DB00712 Flurbiprofen
DB00718 Adefovir Dipivoxil
DB00731 Nateglinide
DB00749 Etodolac
DB00759 Tetracycline
DB00770 Alprostadil
DB00779 Nalidixic Acid
DB00783 Estradiol
DB00787 Acyclovir
DB00788 Naproxen
DB00798 Gentamicin
DB00812 Phenylbutazone
DB00814 Meloxicam
DB00819 Acetazolamide
DB00821 Carprofen
DB00827 Cinoxacin
DB00861 Diflunisal
DB00863 Ranitidine
DB00880 Chlorothiazide
DB00887 Bumetanide
DB00900 Didanosine
DB00903 Ethacrynic acid
DB00908 Quinidine
DB00917 Dinoprostone
DB00927 Famotidine
DB00936 Salicyclic acid
DB00939 Meclofenamic acid
DB00943 Zalcitabine
DB00945 Acetylsalicylic acid
DB00975 Dipyridamole
DB00999 Hydrochlorothiazide
DB01004 Ganciclovir
DB01009 Ketoprofen
DB01016 Glyburide
DB01017 Minocycline
DB01032 Probenecid
DB01033 Mercaptopurine
DB01045 Rifampin
DB01050 Ibuprofen
DB01051 Novobiocin
DB01053 Penicillin G
DB01059 Norfloxacin
DB01060 Amoxicillin
DB01065 Melatonin
DB01076 Atorvastatin
DB01082 Streptomycin
DB01092 Ouabain
DB01098 Rosuvastatin
DB01124 Tolbutamide
DB01137 Levofloxacin
DB01138 Sulfinpyrazone
DB01140 Cefadroxil
DB01147 Cloxacillin
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01197 Captopril
DB01211 Clarithromycin
DB01212 Ceftriaxone
DB01237 Bromodiphenhydramine
DB01248 Docetaxel
DB01268 Sunitinib
DB01303 Oxtriphylline
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB01333 Cefradine
DB01414 Cefacetrile
DB01424 Aminophenazone
DB01435 Antipyrine
DB01583 Liotrix
DB01586 Ursodeoxycholic acid
DB01597 Cilastatin
DB01650 trans-2-hydroxycinnamic acid
DB01790 Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01930 2,4-Dihydroxy-3,3-Dimethyl-Butyrate
DB02119 6-Hydroxymethyl-7,8-Dihydropterin
DB02212 Pyrophosphate 2-
DB02266 Flufenamic Acid
DB02315 Cyclic Guanosine Monophosphate
DB02355 Adenosine-5'-Rp-Alpha-Thio-Triphosphate
DB02475 Deoxyguanidinoproclavaminic acid
DB02527 Cyclic Adenosine Monophosphate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB02659 Cholic Acid
DB02694 Pantoyl Adenylate
DB03107 Beta-Alanine
DB03197 6-Hydroxymethylpterin
DB03215 (2s,5s)-5-Carboxymethylproline
DB03227 Nicotinamide Mononucleotide
DB03431 Adenosine-5'-Diphosphate
DB03553 Glutaric Acid
DB03585 Oxyphenbutazone
DB03783 Phenacetin
DB03793 Benzoic Acid
DB03902 Oxalic Acid
DB04047 [Pterin-6-Yl Methanyl]-Phosphonophosphate
DB04099 Deamido-Nad+
DB04133 Degraded Cephaloridine
DB04147 Lauryl Dimethylamine-N-Oxide
DB04158 6-(Adenosine Tetraphosphate-Methyl)-7,8-Dihydropterin
DB04189 N2-(Carboxyethyl)-L-Arginine
DB04348 Taurocholic Acid
DB04519 Caprylic acid
DB04610 7,8-dihydro-6-hydroxymethyl-7-methyl-7-[2-phenylethyl]-pterin
DB06151 Acetylcysteine
DB06335 Saxagliptin
DB06710 Methyltestosterone
DB07706 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE
DB08837 Tetraethylammonium
DB08846 Ellagic Acid
DB08884 Gadoxetate
DB08912 Dabrafenib
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