DT-Web

DB00319 - Piperacillin


Identification
Name Piperacillin
Accession Number DB00319 (APRD00325)
Type small molecule
Description Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 517.555
Groups approved
Monoisotopic Weight 517.163118933
Pharmacology
Indication For the treatment of polymicrobial infections.
Mechanism of action By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.
Absorption Not absorbed following oral administration.
Protein binding Not Available
Biotransformation Largely not metabolized.
Route of elimination As with other penicillins, PIPRACIL is eliminated primarily by glomerular filtration and tubular secretion; it is excreted rapidly as unchanged drug in high concentrations in the urine. Because PIPRACIL is excreted by the biliary route as well as by the renal route, it can be used safely in appropriate dosage in patients with severely restricted kidney function.
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Atracurium The agent increases the effect of the muscle relaxant
Demeclocycline Possible antagonism of action
Doxacurium chloride The agent increases the effect of the muscle relaxant
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline Possible antagonism of action
Methotrexate The penicillin increases the effect and toxicity of methotrexate
Metocurine The agent increases the effect of the muscle relaxant
Minocycline Possible antagonism of action
Mivacurium The agent increases the effect of the muscle relaxant
Oxytetracycline Possible antagonism of action
Pancuronium The agent increases the effect of the muscle relaxant
Pipecuronium The agent increases the effect of the muscle relaxant
Rocuronium The agent increases the effect of the muscle relaxant
Rolitetracycline Possible antagonism of action
Succinylcholine The agent increases the effect of the muscle relaxant
Tetracycline Possible antagonism of action
Tubocurarine The agent increases the effect of the muscle relaxant
Vecuronium The agent increases the effect of the muscle relaxant
Food Interactions Not Available

Targets


Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0211
Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0028
Penicillin-binding protein 2a
Name Penicillin-binding protein 2a
Gene Name pbp2a
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score Not Available
Penicillin-binding protein 1b
Name Penicillin-binding protein 1b
Gene Name pbp1b
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0231

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.3159

Predictions


Id Partner name Gene Name Score
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1476
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1437
6142 Solute carrier family 22 member 8 SLC22A8 0.0999
633 Penicillin-binding proteins 1A/1B pbpA 0.0859
118 Organic cation/carnitine transporter 2 SLC22A5 0.0781
1024 Solute carrier family 22 member 11 SLC22A11 0.069
587 Serum albumin ALB 0.0573
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0534
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0511
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0511
6143 Solute carrier family 22 member 7 SLC22A7 0.0477
4512 Cytochrome P450 3A4 CYP3A4 0.0473
4200 Cytochrome P450 1A2 CYP1A2 0.0257
20 Prostaglandin G/H synthase 1 PTGS1 0.0256
645 Penicillin-binding protein 1A mrcA 0.0252
5805 Penicillin-binding protein 1A ponA 0.0252
6185 Penicillin-binding protein 1A mrcA 0.0252
6799 Penicillin-binding protein 1A pbpA 0.0252
290 Prostaglandin G/H synthase 2 PTGS2 0.025
738 Monocarboxylate transporter 1 SLC16A1 0.025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0234
543 Penicillin-binding protein 1B mrcB 0.0231
6186 Penicillin-binding protein 1B ponB 0.0231
6822 Penicillin-binding protein 1b pbp1b 0.0231
867 Penicillin-binding protein 3 pbpC 0.0211
6119 Penicillin-binding protein 3 pbp3 0.0211
7157 Penicillin-binding protein 3 LMHCC_2184 0.0211
7162 Penicillin-binding protein 3 pbpB 0.0211
7172 Penicillin-binding protein 3 pbp3 0.0211
3760 Penicillin-binding protein 5 precursor dacA 0.021
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0198
1 Peptidoglycan synthetase ftsI ftsI 0.0192
4155 Peptidoglycan synthetase ftsI ftsI 0.0192
819 Penicillin-binding protein 4 dacB 0.0186
4757 Cytochrome P450 2C9 CYP2C9 0.018
1588 Multidrug resistance protein 1 ABCB1 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
2164 Multidrug resistance-associated protein 4 ABCC4 0.0142
592 Carbonic anhydrase 4 CA4 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
4119 Cytochrome P450 2D6 CYP2D6 0.0136
295 Carbonic anhydrase 1 CA1 0.0133
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0132
6016 Cytochrome P450 2C19 CYP2C19 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
3426 Glutamine synthetase glnA 0.0119
3987 Glutamine synthetase GLUL 0.0119
4924 Cytochrome P450 2C8 CYP2C8 0.0119
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
357 Carbonic anhydrase 2 CA2 0.0116
4790 Glycosyltransferase GtfA gtfA 0.011
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0106
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
862 Multidrug resistance-associated protein 1 ABCC1 0.0101
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0094
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
6145 Solute carrier family 22 member 1 SLC22A1 0.008
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0075
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
776 Bile salt export pump ABCB11 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6144 Solute carrier family 22 member 2 SLC22A2 0.007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0068
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0066
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
6024 Cytochrome P450 1A1 CYP1A1 0.0064
5626 Nucleoside diphosphate kinase B NME2 0.006
2320 Thymidine kinase, cytosolic TK1 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0059
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0056
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0056
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0054
833 Organic cation/carnitine transporter 1 SLC22A4 0.0054
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0054
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0053
4118 Cytochrome P450 3A5 CYP3A5 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0052
6013 Cytochrome P450 2E1 CYP2E1 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6107 Cytochrome P450 3A7 CYP3A7 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0046
373 Transthyretin TTR 0.0046
3917 Methylenetetrahydrofolate reductase MTHFR 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0045
6106 Cytochrome P450 2C18 CYP2C18 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
5718 Cytochrome P450 2A6 CYP2A6 0.0044
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
6141 Sodium/bile acid cotransporter SLC10A1 0.0041
24 Thymidylate synthase TMP1 0.0041
359 Thymidylate synthase TYMS 0.0041
2626 Thymidylate synthase thyA 0.0041
2729 Thymidylate synthase thyA 0.0041
5352 Thymidylate synthase THYA 0.0041
275 Arachidonate 5-lipoxygenase ALOX5 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0036
244 Angiotensin-converting enzyme ACE 0.0036
6131 Carbonic anhydrase 14 CA14 0.0035
492 Histamine H1 receptor HRH1 0.0035
6148 Multidrug resistance-associated protein 7 ABCC10 0.0035
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
3932 Glutathione S-transferase A2 GSTA2 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
654 Flavin reductase BLVRB 0.0029
6147 Solute carrier family 22 member 3 SLC22A3 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
1757 Myeloperoxidase MPO 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
293 Gamma-glutamyl hydrolase GGH 0.0026
4773 Deoxycytidine kinase DCK 0.0026
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
1650 Heme carrier protein 1 SLC46A1 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0021
3941 Amine oxidase [flavin-containing] A MAOA 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
146 Androgen receptor AR 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
1654 Interleukin-1 beta IL1B 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0018
6014 Cytochrome P450 2A13 CYP2A13 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
494 Caspase-1 CASP1 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0015
6030 Cytochrome P450 2B6 CYP2B6 0.0015
1507 Cytochrome c CYCS 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
4217 Telomerase reverse transcriptase TERT 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
2077 Caspase-3 CASP3 0.0013
702 UMP-CMP kinase CMPK1 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
6137 Multidrug resistance-associated protein 6 ABCC6 0.0012
2021 Thrombomodulin THBD 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
997 Protein kinase C beta type PRKCB 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
6218 Pannexin-1 PANX1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
5818 Folate receptor alpha FOLR1 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
3587 Gastrotropin FABP6 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0006
124 Histamine H2 receptor HRH2 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0006
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0006
3810 Catechol O-methyltransferase COMT 0.0006
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0005
4604 Liver carboxylesterase 1 CES1 0.0005
3811 Cytochrome P450 19A1 CYP19A1 0.0005
6020 Aldehyde oxidase AOX1 0.0005
136 Estrogen receptor ESR1 0.0005
365 Dihydrofolate reductase DHFR 0.0004
2381 Dihydrofolate reductase DFR1 0.0004
2833 Dihydrofolate reductase Not Available 0.0004
2931 Dihydrofolate reductase folA 0.0004
3544 Dihydrofolate reductase folA 0.0004
3682 Dihydrofolate reductase folA 0.0004
6642 Dihydrofolate reductase folA 0.0004
6756 Dihydrofolate reductase dfrA 0.0004
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