DT-Web

DB00728 - Rocuronium


Identification
Name Rocuronium
Accession Number DB00728 (APRD01221)
Type small molecule
Description Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is marketed under the trade name of Zemuron in the United States and Esmeron in most other countries. There is considered to be a risk of allergic reaction to the drug in some patients (particularly those with asthma), but a similar incidence of allergic reactions has been observed by using other members of the same drug class (non-depolarizing neuromuscular blocking drugs). The ?-cyclodextrin derivative sugammadex (trade name Bridion) has been recently introduced as a novel agent to reverse the action of rocuronium.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 529.7742
Groups approved
Monoisotopic Weight 529.400533194
Pharmacology
Indication For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Mechanism of action Rocuronium acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. Rocuronium acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not released and muscle contraction does not occur. Evidence also suggests that nondepolarizing agents can affect ACh release. It has been hypothesized that nondepolarzing agents bind to postjunctional ("curare") receptors and may therefore interfere with the sodium and potassium flux, which is responsible for depolarization and repolarization of the membranes involved in muscle contraction.
Absorption Poorly absorbed from the GI tract.
Protein binding Approximately 30% bound to human plasma proteins.
Biotransformation Rocuronium is metabolized to a less active metabolite, 17-desacetyl-rocuronium, and is eliminated primarily by the liver.
Route of elimination Studies of distribution, metabolism, and excretion in cats and dogs indicate that rocuronium is eliminated primarily by the liver.
Toxicity No cases of significant accidental or intentional overdose have been reported. Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin The agent increases the effect of muscle relaxant
Clindamycin The agent increases the effect of muscle relaxant
Colistimethate Colistimethate may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. If possible, avoid concomitant use of these products. Monitor for deeper, prolonged neuromuscular-blocking effects (respiratory paralysis) in patients receiving concomitant neuromuscular-blocking agents and polymyxin antibiotics (e.g., colistimethate, polymyxin B).
Gentamicin The agent increases the effect of muscle relaxant
Lincomycin The agent increases the effect of muscle relaxant
Netilmicin The agent increases the effect of muscle relaxant
Piperacillin The agent increases the effect of the muscle relaxant
Tobramycin The agent increases the effect of the muscle relaxant
Food Interactions Not Available

Targets


Neuronal acetylcholine receptor subunit alpha-2
Name Neuronal acetylcholine receptor subunit alpha-2
Gene Name CHRNA2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Jonsson Fagerlund M, Dabrowski M, Eriksson LI: Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. - Pubmed
  • Jonsson M, Gurley D, Dabrowski M, Larsson O, Johnson EC, Eriksson LI: Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology. 2006 Sep;105(3):521-33. - Pubmed
  • Liu M, Dilger JP: Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6577
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Milchert M, Spassov A, Meissner K, Nedeljkov V, Lehmann C, Wendt M, Loster BW, Mazurkiewicz-Janik M, Gedrange T, Pavlovic D: Skeletal muscle relaxants inhibit rat tracheal smooth muscle tone in vitro. J Physiol Pharmacol. 2009 Dec;60 Suppl 8:5-11. - Pubmed
DTHybrid score 0.398
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action unknown
Actions antagonist
References
  • Min KT, Wu CL, Yang J: Nondepolarizing neuromuscular blockers inhibit the serotonin-type 3A receptor expressed in Xenopus oocytes. Anesth Analg. 2000 Feb;90(2):476-81. - Pubmed
DTHybrid score 0.2307

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of - type I
DTHybrid score 0.2623
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate
References
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
DTHybrid score 0.1843

Predictions


Id Partner name Gene Name Score
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1801
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1755
3923 Cholinesterase BCHE 0.1228
4119 Cytochrome P450 2D6 CYP2D6 0.115
4512 Cytochrome P450 3A4 CYP3A4 0.115
1588 Multidrug resistance protein 1 ABCB1 0.1058
6144 Solute carrier family 22 member 2 SLC22A2 0.1054
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0926
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0749
4757 Cytochrome P450 2C9 CYP2C9 0.073
4200 Cytochrome P450 1A2 CYP1A2 0.0667
474 Acetylcholinesterase ACHE 0.0661
4118 Cytochrome P450 3A5 CYP3A5 0.057
6016 Cytochrome P450 2C19 CYP2C19 0.0542
492 Histamine H1 receptor HRH1 0.0486
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0481
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.046
4924 Cytochrome P450 2C8 CYP2C8 0.0444
6107 Cytochrome P450 3A7 CYP3A7 0.0427
502 5-hydroxytryptamine 2A receptor HTR2A 0.042
118 Organic cation/carnitine transporter 2 SLC22A5 0.0406
587 Serum albumin ALB 0.038
833 Organic cation/carnitine transporter 1 SLC22A4 0.0373
6142 Solute carrier family 22 member 8 SLC22A8 0.0367
6013 Cytochrome P450 2E1 CYP2E1 0.0366
6147 Solute carrier family 22 member 3 SLC22A3 0.0336
6030 Cytochrome P450 2B6 CYP2B6 0.0333
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0324
831 D(2) dopamine receptor DRD2 0.0318
6024 Cytochrome P450 1A1 CYP1A1 0.0317
713 Sodium-dependent dopamine transporter SLC6A3 0.0307
556 Alpha-1A adrenergic receptor ADRA1A 0.0302
23 D(1A) dopamine receptor DRD1 0.03
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0299
776 Bile salt export pump ABCB11 0.0298
6141 Sodium/bile acid cotransporter SLC10A1 0.0293
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0291
320 5-hydroxytryptamine 1A receptor HTR1A 0.0277
590 5-hydroxytryptamine 2C receptor HTR2C 0.0263
1729 Solute carrier family 22 member 6 SLC22A6 0.0259
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0252
632 Alpha-1B adrenergic receptor ADRA1B 0.0251
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0245
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0241
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0236
318 Alpha-2A adrenergic receptor ADRA2A 0.0231
862 Multidrug resistance-associated protein 1 ABCC1 0.023
6143 Solute carrier family 22 member 7 SLC22A7 0.0229
723 Cytosolic phospholipase A2 PLA2G4A 0.0228
5718 Cytochrome P450 2A6 CYP2A6 0.0219
378 Alpha-2C adrenergic receptor ADRA2C 0.0216
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0205
885 5-hydroxytryptamine 1B receptor HTR1B 0.0204
629 Alpha-2B adrenergic receptor ADRA2B 0.0203
432 D(4) dopamine receptor DRD4 0.0185
824 Sodium-dependent serotonin transporter SLC6A4 0.0181
33 Cystine/glutamate transporter SLC7A11 0.018
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0178
638 D(3) dopamine receptor DRD3 0.0168
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0166
528 5-hydroxytryptamine 1E receptor HTR1E 0.0165
2164 Multidrug resistance-associated protein 4 ABCC4 0.0162
725 5-hydroxytryptamine 1D receptor HTR1D 0.0159
1256 5-hydroxytryptamine 6 receptor HTR6 0.0153
789 Alpha-1D adrenergic receptor ADRA1D 0.0151
1024 Solute carrier family 22 member 11 SLC22A11 0.0149
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0147
163 D(1B) dopamine receptor DRD5 0.0144
696 Kappa-type opioid receptor OPRK1 0.0144
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0143
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0139
716 5-hydroxytryptamine 7 receptor HTR7 0.0139
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0133
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0133
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0129
3587 Gastrotropin FABP6 0.0129
847 Mu-type opioid receptor OPRM1 0.0128
904 Glutathione S-transferase P GSTP1 0.0127
136 Estrogen receptor ESR1 0.0126
94 5-hydroxytryptamine 4 receptor HTR4 0.0125
756 Sex hormone-binding globulin SHBG 0.0119
731 HIV-1 protease HIV-1 protease 0.0114
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.011
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.011
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0108
244 Angiotensin-converting enzyme ACE 0.0108
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0103
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0103
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0102
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0102
1898 Cytochrome P450 1B1 CYP1B1 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
869 Estrogen receptor beta ESR2 0.0095
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0095
467 Delta-type opioid receptor OPRD1 0.0094
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0094
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0092
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0092
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0092
672 Prostaglandin F2-alpha receptor PTGFR 0.009
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0089
766 Beta-2 adrenergic receptor ADRB2 0.0088
871 Glucocorticoid receptor NR3C1 0.0088
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0088
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0086
6148 Multidrug resistance-associated protein 7 ABCC10 0.0086
737 Mineralocorticoid receptor NR3C2 0.0086
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0083
6167 Organic solute transporter subunit beta OSTB 0.0083
6166 Organic solute transporter subunit alpha OSTA 0.0083
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0081
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.008
738 Monocarboxylate transporter 1 SLC16A1 0.0079
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0079
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0076
6106 Cytochrome P450 2C18 CYP2C18 0.0076
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0072
193 Beta-1 adrenergic receptor ADRB1 0.0072
436 5-hydroxytryptamine 2B receptor HTR2B 0.0072
20 Prostaglandin G/H synthase 1 PTGS1 0.0071
146 Androgen receptor AR 0.0071
3941 Amine oxidase [flavin-containing] A MAOA 0.0071
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0071
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0071
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0065
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0064
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
3811 Cytochrome P450 19A1 CYP19A1 0.0064
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0063
380 Cytochrome P450 17A1 CYP17A1 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
124 Histamine H2 receptor HRH2 0.0062
290 Prostaglandin G/H synthase 2 PTGS2 0.0062
594 Thyroxine-binding globulin SERPINA7 0.006
164 Histamine H4 receptor HRH4 0.006
319 Opioid receptor, sigma 1 OPRS1 0.006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0059
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
6014 Cytochrome P450 2A13 CYP2A13 0.0059
4773 Deoxycytidine kinase DCK 0.0057
758 Thyroid hormone receptor alpha THRA 0.0056
3939 Amine oxidase [flavin-containing] B MAOB 0.0056
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
6136 Multidrug resistance-associated protein 5 ABCC5 0.0054
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0053
2129 Sucrase-isomaltase, intestinal SI 0.0051
346 Thyroid hormone receptor beta-1 THRB 0.005
6171 Solute carrier family 28 member 3 SLC28A3 0.0049
1517 Beta-3 adrenergic receptor ADRB3 0.0049
174 Sigma 1-type opioid receptor SIGMAR1 0.0048
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0048
465 Calmodulin CALM1 0.0046
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
976 Platelet glycoprotein IX GP9 0.0044
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
469 Annexin A1 ANXA1 0.0042
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
6070 Nischarin NISCH 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
6432 Transporter snf 0.004
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
694 Matrix protein 2 M 0.0039
6031 Cytochrome P450 3A43 CYP3A43 0.0038
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
373 Transthyretin TTR 0.0038
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
6149 Solute carrier family 22 member 10 SLC22A10 0.0037
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
468 Cytochrome P450 4A11 CYP4A11 0.0035
1830 5'-nucleotidase NT5E 0.0035
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
199 Monocarboxylate transporter 8 SLC16A2 0.0034
125 DNA polymerase beta POLB 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0033
511 5-hydroxytryptamine 1F receptor HTR1F 0.0033
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
6085 Fatty acid-binding protein, intestinal FABP2 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
5126 Arginase rocF 0.0029
6218 Pannexin-1 PANX1 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
1341 Histamine H3 receptor HRH3 0.0028
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
6137 Multidrug resistance-associated protein 6 ABCC6 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
740 Argininosuccinate synthase ASS1 0.0027
865 Argininosuccinate synthase ASS1 0.0027
2680 Argininosuccinate synthase argG 0.0027
3194 Argininosuccinate synthase argG 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0026
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0026
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0026
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0025
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0025
3947 Xanthine dehydrogenase/oxidase XDH 0.0025
6151 Monocarboxylate transporter 10 SLC16A10 0.0025
1630 Integrin beta-2 ITGB2 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
1618 High affinity nerve growth factor receptor NTRK1 0.0023
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0022
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0022
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0022
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
3810 Catechol O-methyltransferase COMT 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
558 Solute carrier family 12 member 1 SLC12A1 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
2021 Thrombomodulin THBD 0.0018
572 Integrin alpha-L ITGAL 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0018
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0017
702 UMP-CMP kinase CMPK1 0.0017
2300 Lysozyme E 0.0017
3633 Lysozyme R 0.0017
5597 Lysozyme 17 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
4122 Histone deacetylase 2 HDAC2 0.0016
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
1864 RET proto-oncogene RET 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0015
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
5934 Cytochrome P450 26A1 CYP26A1 0.0015
6146 High affinity copper uptake protein 1 SLC31A1 0.0015
1010 Cytochrome P450 51A1 CYP51A1 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
5294 Nucleoside diphosphate kinase A NME1 0.0014
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0014
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0014
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0014
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
6042 Prostaglandin reductase 2 PTGR2 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
5818 Folate receptor alpha FOLR1 0.0013
6220 Aryl hydrocarbon receptor AHR 0.0013
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
6043 Putative G-protein coupled receptor 44 GPR44 0.0012
273 Apoptosis regulator Bcl-2 BCL2 0.0012
260 Cytochrome P450 51 ERG11 0.0012
761 Cytochrome P450 51 ERG11 0.0012
3163 Cytochrome P450 51 cyp51 0.0012
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
284 DNA-directed RNA polymerase beta chain rpoB 0.0012
5773 DNA-directed RNA polymerase beta chain rpoB 0.0012
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0012
293 Gamma-glutamyl hydrolase GGH 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
1757 Myeloperoxidase MPO 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
1313 Lactoylglutathione lyase GLO1 0.0011
504 Mast/stem cell growth factor receptor KIT 0.001
1650 Heme carrier protein 1 SLC46A1 0.001
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.001
2981 Phospholipase A2, membrane associated PLA2G2A 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0009
614 Progesterone receptor PGR 0.0009
952 Dipeptidyl peptidase 4 DPP4 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0008
6500 Phospholipase A2 PLA2G1B 0.0008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0008
6020 Aldehyde oxidase AOX1 0.0008
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0008
24 Thymidylate synthase TMP1 0.0008
359 Thymidylate synthase TYMS 0.0008
2626 Thymidylate synthase thyA 0.0008
2729 Thymidylate synthase thyA 0.0008
5352 Thymidylate synthase THYA 0.0008
365 Dihydrofolate reductase DHFR 0.0007
2381 Dihydrofolate reductase DFR1 0.0007
2833 Dihydrofolate reductase Not Available 0.0007
2931 Dihydrofolate reductase folA 0.0007
3544 Dihydrofolate reductase folA 0.0007
3682 Dihydrofolate reductase folA 0.0007
6642 Dihydrofolate reductase folA 0.0007
6756 Dihydrofolate reductase dfrA 0.0007
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0007
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0007
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0007
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0007
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0006
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0006
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0006
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