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Uridine phosphorylase


Partner ID 2257
Name Uridine phosphorylase
Synonyms 3987
Gene name udp
General function Nucleotide transport and metabolism
Specific function Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Gene sequence + ...

ATGTCCAAGTCTGATGTTTTTCATCTCGGCCTCACTAAAAACGATTTACAAGGGGCTACGCTTGCCATCGTCCCTGGCGACCCGGATCGTGTGGAAAAGATCGCCGCGCTGATGGATAAGCCGGTTAAGCTGGCATCTCACCGCGAATTCACTACCTGGCGTGCAGAGCTGGATGGTAAACCTGTTATCGTCTGCTCTACCGGTATCGGCGGCCCGTCTACCTCTATTGCTGTTGAAGAGCTGGCACAGCTGGGCATTCGCACCTTCCTGCGTATCGGTACAACGGGCGCTATTCAGCCGCATATTAATGTGGGTGATGTCCTGGTTACCACGGCGTCTGTCCGTCTGGATGGCGCGAGCCTGCACTTCGCACCGCTGGAATTCCCGGCTGTCGCTGATTTCGAATGTACGACTGCGCTGGTTGAAGCTGCGAAATCCATTGGCGCGACAACTCACGTTGGCGTGACAGCTTCTTCTGATACCTTCTACCCAGGTCAGGAACGTTACGATACTTACTCTGGTCGCGTAGTTCGTCACTTTAAAGGTTCTATGGAAGAGTGGCAGGCGATGGGCGTAATGAACTATGAAATGGAATCTGCAACCCTGCTGACCATGTGTGCAAGTCAGGGCCTGCGTGCCGGTATGGTAGCGGGTGTTATCGTTAACCGCACCCAGCAAGAGATCCCGAATGCTGAGACGATGAAACAAACCGAAAGCCATGCGGTGAAAATCGTGGTGGAAGCGGCGCGTCGTCTGCTGTAA
Protein sequence + ...

MSKSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVKIVVEAARRLL
GO Classification
component
cytoplasm
cell
intracellular
function
transferase activity, transferring pentosyl groups
catalytic activity
uridine phosphorylase activity
transferase activity
transferase activity, transferring glycosyl groups
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleotide metabolism
nucleoside metabolism
physiological process
nucleotide catabolism
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01629 5-Fluorouridine
DB02256 2'-Deoxyuridine
DB02681 Meta Vanadate
DB03101 Ribose-1-Phosphate
DB04485 Deoxythymidine
DB06872 1-((2-HYDROXYETHOXY)METHYL)-5-(PHENYLTHIO)PYRIMIDINE-2,4(1H,3H)-DIONE
DB06873 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)PYRIMIDINE-2,4(1H,3H)-DIONE
DB07437 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE
DB07439 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)-6-HYDROXYPYRIMIDINE-2,4(1H,3H)-DIONE

Associated as Prediction

Id Name
DB00122 Choline
DB00127 Spermine
DB00152 Thiamine
DB00184 Nicotine
DB00206 Reserpine
DB00220 Nelfinavir
DB00224 Indinavir
DB00242 Cladribine
DB00280 Disopyramide
DB00318 Codeine
DB00331 Metformin
DB00345 Aminohippurate
DB00368 Norepinephrine
DB00396 Progesterone
DB00406 Gentian Violet
DB00413 Pramipexole
DB00441 Gemcitabine
DB00457 Prazosin
DB00458 Imipramine
DB00468 Quinine
DB00477 Chlorpromazine
DB00501 Cimetidine
DB00520 Caspofungin
DB00526 Oxaliplatin
DB00536 Guanidine
DB00544 Fluorouracil
DB00575 Clonidine
DB00594 Amiloride
DB00619 Imatinib
DB00624 Testosterone
DB00640 Adenosine
DB00654 Latanoprost
DB00661 Verapamil
DB00667 Histamine Phosphate
DB00668 Epinephrine
DB00683 Midazolam
DB00709 Lamivudine
DB00728 Rocuronium
DB00783 Estradiol
DB00787 Acyclovir
DB00811 Ribavirin
DB00863 Ranitidine
DB00900 Didanosine
DB00908 Quinidine
DB00914 Phenformin
DB00915 Amantadine
DB00917 Dinoprostone
DB00925 Phenoxybenzamine
DB00987 Cytarabine
DB00988 Dopamine
DB01004 Ganciclovir
DB01032 Probenecid
DB01033 Mercaptopurine
DB01035 Procainamide
DB01073 Fludarabine
DB01075 Diphenhydramine
DB01114 Chlorpheniramine
DB01151 Desipramine
DB01193 Acebutolol
DB01199 Tubocurarine
DB01232 Saquinavir
DB01337 Pancuronium
DB01339 Vecuronium
DB01614 Acepromazine
DB01621 Pipotiazine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01629 5-Fluorouridine
DB01643 Thymidine-5'-Phosphate
DB01667 8-azaguanine
DB02031 (6s)-5,6,7,8-Tetrahydrofolate
DB02222 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine
DB02223 Ly231514 Tetra Glu
DB02230 Immucillin-G
DB02256 2'-Deoxyuridine
DB02301 5,10-Methylene-6-Hydrofolic Acid
DB02324 5-Iodo-2'-Deoxyuridine-5'-Monophosphate
DB02377 Guanine
DB02391 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One
DB02452 Thymidine-5'-Triphosphate
DB02467 S-Oxymethionine
DB02495 9-(4-Hydroxybutyl)-N2-Phenylguanine
DB02500 6-(Dihydroxy-Isobutyl)-Thymine
DB02568 Peldesine
DB02681 Meta Vanadate
DB02745 Uridine
DB02752 Tosyl-D-Proline
DB02765 9-Hydroxypropyladenine, R-Isomer
DB02796 9-Deazainosine
DB02843 Alpha-D-Glucose-1-Phosphate
DB02857 Guanosine
DB02899 N-Carboxymethionine
DB02921 (South)-Methanocarba-Thymidine
DB03000 9-Hydroxypropyladenine, S-Isomer
DB03038 LY341770
DB03101 Ribose-1-Phosphate
DB03128 Acetylcholine
DB03157 N,O-Didansyl-L-Tyrosine
DB03274 2'-5'dideoxyuridine
DB03280 P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate
DB03312 5-Bromovinyldeoxyuridine
DB03431 Adenosine-5'-Diphosphate
DB03541 10-Propargyl-5,8-Dideazafolic Acid
DB03551 4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol
DB03558 Sp-876
DB03566 Spermidine
DB03609 3-Deoxyguanosine
DB03666 3'-Azido-3'-Deoxythymidine-5'-Monophosphate
DB03723 2'-Deoxy-Thymidine-Beta-L-Rhamnose
DB03751 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose
DB03761 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
DB03800 2'-deoxyuridylic acid
DB03804 5-Bromothienyldeoxyuridine
DB03818 N-[Tosyl-D-Prolinyl]Amino-Ethanethiol
DB03846 5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate
DB03881 MT-Immucillin-H
DB04076 Hypoxanthine
DB04139 6-Hydroxypropylthymine
DB04160 Diphosphate
DB04260 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
DB04272 Citric Acid
DB04348 Taurocholic Acid
DB04447 1,4-Dithiothreitol
DB04457 2'-Deoxyguanosine-5'-Monophosphate
DB04485 Deoxythymidine
DB04503 Sp-722
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04574 Estropipate
DB04586 2-bromophenol
DB04627 Cyclouridine
DB04696 4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN
DB04753 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
DB04754 GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
DB04757 GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
DB04830 Buformin
DB06872 1-((2-HYDROXYETHOXY)METHYL)-5-(PHENYLTHIO)PYRIMIDINE-2,4(1H,3H)-DIONE
DB06873 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)PYRIMIDINE-2,4(1H,3H)-DIONE
DB07437 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE
DB07439 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)-6-HYDROXYPYRIMIDINE-2,4(1H,3H)-DIONE
DB08131 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-3-METHYL-BUTYRIC ACID
DB08837 Tetraethylammonium
DB08838 Agmatine
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