DT-Web: DB00477

Identification

Name

Chlorpromazine

Accession Number

DB00477 (APRD00482)

Type

small molecule

Description

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

318.864

Groups

approved

Monoisotopic Weight

318.095747015

Pharmacology

Indication

For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.

Mechanism of action

Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).

Absorption

Readily absorbed from the GI tract. Bioavailability varies due to first-pass metabolism by the liver.

Protein binding

> 90% to plasma proteins, primarily albumin

Biotransformation

Extensively metabolized in the liver and kidneys. It is extensively metabolized by cytochrome P450 isozymes CYP2D6 (major pathway), CYP1A2 and CYP3A4. Approximately 10 to 12 major metabolite have been identified. Hydroxylation at positions 3 and 7 of the phenothiazine nucleus and the N-dimethylaminopropyl side chain undergoes demethylation and is also metabolized to an N-oxide. In urine, 20% of chlopromazine and its metabolites are excreted unconjugated in the urine as unchanged drug, demonomethylchlorpromazine, dedimethylchlorpromazine, their sulfoxide metabolites, and chlorpromazine-N-oxide. The remaining 80% consists of conjugated metabolites, principally O-glucuronides and small amounts of ethereal sulfates of the mono- and dihydroxy-derivatives of chlorpromazine and their sulfoxide metabolites. The major metabolites are the monoglucuronide of N-dedimethylchlorpromazine and 7-hydroxychlorpromazine. Approximately 37% of the administered dose of chlorpromazine is excreted in urine.

Route of elimination

Kidneys, ~ 37% excreted in urine

Toxicity

Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amphetamine	Decreased anorexic effect, may increase psychotic symptoms
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Benzphetamine	Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Bromocriptine	The phenothiazine decreases the effect of bromocriptine
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Dexfenfluramine	Decreased anorexic effect, may increase psychotic symptoms.
Dextroamphetamine	Decreased anorexic effect, may increases psychotic symptoms
Diethylpropion	Decreased anorexic effect, may increase psychotic symptoms
Dihydrocodeine	Phenothiazines may enhance hypotensive effects of opioid analgesics. It is recommended to monitor patients for hypotension.
Donepezil	Possible antagonism of action
Fenfluramine	Decreased anorexic effect, may increase psychotic symptoms
Galantamine	Possible antagonism of action
Gatifloxacin	Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	Chlorpromazine may decrease the effect of guanethidine.
Levofloxacin	Increased risk of cardiotoxicity and arrhythmias
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mazindol	Decreased anorexic effect, may increase psychotic symptoms
Meperidine	Increased sedation and hypotension
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Methamphetamine	Decreased anorexic effect, may increases psychotic symptoms
Metrizamide	Increased risk of convulsions
Phendimetrazine	Decreased anorexic effect, may increases psychotic symptoms
Phenmetrazine	Decreased anorexic effect, may increase psychotic symptoms
Phentermine	Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine	Decreased anorexic effect, may increase psychotic symptoms
Pindolol	Increased effect of both drugs
Propranolol	Increased effect of both drugs
Rivastigmine	Possible antagonism of action
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Chlorpromazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen	Chlorpromazine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin	Chlorpromazine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Chlorpromazine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Chlorpromazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Chlorpromazine if Terbinafine is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine	May cause dopamine deficiency. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tolterodine	Chlorpromazine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Chlorpromazine may decrease the effect of Tramadol by decreasing active metabolite production.
Trimethobenzamide	Trimethobenzamide and Chlorpromazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Chlorpromazine, a strong CYP2D6 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP2D6 substrate. Caution should be used during concomitant therapy.
Triprolidine	The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Chlorpromazine. Monitor for symptoms of ventricular arrhythmias. Additive anticholinergic and CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Chlorpromazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Chlorpromazine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Chlorpromazine is initiated, discontinued, or dose changed.
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). Chlorpromazine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if chlorpromazine is initiated, discontinued or dose changed.

Food Interactions

Take with food to reduce irritation.
Avoid alcohol.

D(2) dopamine receptor
Name	D(2) dopamine receptor
Gene Name	DRD2
Pharmacological action	yes
Actions	antagonist
References	Oades RD, Rao ML, Bender S, Sartory G, Muller BW: Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy. Behav Pharmacol. 2000 Jun;11(3-4):317-30. - Pubmed Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed Wu S, Xing Q, Gao R, Li X, Gu N, Feng G, He L: Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neurosci Lett. 2005 Mar 7;376(1):1-4. Epub 2004 Dec 2. - Pubmed Wu SN, Gao R, Xing QH, Li HF, Shen YF, Gu NF, Feng GY, He L: Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. Acta Pharmacol Sin. 2006 Aug;27(8):966-70. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Seeman P: Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73. - Pubmed
DTHybrid score	0.5969
D(1A) dopamine receptor
Name	D(1A) dopamine receptor
Gene Name	DRD1
Pharmacological action	yes
Actions	antagonist
References	Kanba S, Suzuki E, Nomura S, Nakaki T, Yagi G, Asai M, Richelson E: Affinity of neuroleptics for D1 receptor of human brain striatum. J Psychiatry Neurosci. 1994 Jul;19(4):265-9. - Pubmed
DTHybrid score	0.47
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Kusumi I, Takahashi Y, Suzuki K, Kameda K, Koyama T: Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. J Neural Transm. 2000;107(3):295-302. - Pubmed Yamada J, Sugimoto Y, Horisaka K: Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice. Biol Pharm Bull. 1995 Nov;18(11):1580-3. - Pubmed
DTHybrid score	0.5095
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	yes
Actions	antagonist
References	Cosi C, Koek W: Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells. Eur J Pharmacol. 2001 Dec 14;433(1):55-62. - Pubmed Newman-Tancredi A, Gavaudan S, Conte C, Chaput C, Touzard M, Verriele L, Audinot V, Millan MJ: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. - Pubmed
DTHybrid score	0.4013
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	yes
Actions	antagonist
References	Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
DTHybrid score	0.6193
Alpha-1B adrenergic receptor
Name	Alpha-1B adrenergic receptor
Gene Name	ADRA1B
Pharmacological action	yes
Actions	antagonist
References	Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
DTHybrid score	0.4199
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	yes
Actions	antagonist
References	Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed Church MK, Young KD: The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine. Br J Pharmacol. 1983 Apr;78(4):671-9. - Pubmed Johnson HG, Miller MD: Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine. Agents Actions. 1979 Aug;9(3):239-43. - Pubmed Palmer GC, Wagner HR, Palmer SJ, Manian AA: Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol. Arch Int Pharmacodyn Ther. 1978 Jun;233(2):314-25. - Pubmed Ruffolo RR, Patil PN: Kinetics of blockade of different receptors by chlorpromazine in rabbit stomach strips. Eur J Pharmacol. 1978 Mar 15;48(2):151-7. - Pubmed
DTHybrid score	0.6599

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Otani K, Aoshima T: Pharmacogenetics of classical and new antipsychotic drugs. Ther Drug Monit. 2000 Feb;22(1):118-21. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Yoshii K, Kobayashi K, Tsumuji M, Tani M, Shimada N, Chiba K: Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes. Life Sci. 2000;67(2):175-84. - Pubmed Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7453
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Yoshii K, Kobayashi K, Tsumuji M, Tani M, Shimada N, Chiba K: Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes. Life Sci. 2000;67(2):175-84. - Pubmed Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.561
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8291
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3301
Cholinesterase
Name	Cholinesterase
Gene Name	BCHE
Actions	inhibitor
References	Nasello AG, Gidali D, Felicio LF: A comparative study of the anticholinesterase activity of several antipsychotic agents. Pharmacol Biochem Behav. 2003 Jul;75(4):895-901. - Pubmed Muraoka S, Miura T: Inactivation of cholinesterase induced by chlorpromazine cation radicals. Pharmacol Toxicol. 2003 Feb;92(2):100-4. - Pubmed Spinedi A, Pacini L, Limatola C, Luly P, Farias RN: A study of human erythrocyte acetylcholinesterase inhibition by chlorpromazine. Biochem J. 1991 Sep 1;278 ( Pt 2):461-3. - Pubmed
DTHybrid score	0.6192

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Boulton DW, DeVane CL, Liston HL, Markowitz JS: In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9. - Pubmed
DTHybrid score	0.5685
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
DTHybrid score	0.3239
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score	0.1662

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.5685
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.3239
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions
References	Not Available
DTHybrid score	0.1662

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.3423
6016	Cytochrome P450 2C19	CYP2C19	0.3222
318	Alpha-2A adrenergic receptor	ADRA2A	0.3114
4118	Cytochrome P450 3A5	CYP3A5	0.2656
590	5-hydroxytryptamine 2C receptor	HTR2C	0.2304
4924	Cytochrome P450 2C8	CYP2C8	0.2207
6030	Cytochrome P450 2B6	CYP2B6	0.1995
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1994
638	D(3) dopamine receptor	DRD3	0.1967
6107	Cytochrome P450 3A7	CYP3A7	0.1951
789	Alpha-1D adrenergic receptor	ADRA1D	0.1921
432	D(4) dopamine receptor	DRD4	0.1832
629	Alpha-2B adrenergic receptor	ADRA2B	0.1823
378	Alpha-2C adrenergic receptor	ADRA2C	0.1735
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.1621
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1568
6024	Cytochrome P450 1A1	CYP1A1	0.1534
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1441
163	D(1B) dopamine receptor	DRD5	0.1436
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1406
6144	Solute carrier family 22 member 2	SLC22A2	0.1391
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1391
824	Sodium-dependent serotonin transporter	SLC6A4	0.1388
51	Muscarinic acetylcholine receptor M3	CHRM3	0.1343
474	Acetylcholinesterase	ACHE	0.1292
766	Beta-2 adrenergic receptor	ADRB2	0.1288
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1214
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1161
274	Muscarinic acetylcholine receptor M5	CHRM5	0.1141
716	5-hydroxytryptamine 7 receptor	HTR7	0.1123
713	Sodium-dependent dopamine transporter	SLC6A3	0.1119
450	Muscarinic acetylcholine receptor M4	CHRM4	0.111
193	Beta-1 adrenergic receptor	ADRB1	0.1102
5718	Cytochrome P450 2A6	CYP2A6	0.1077
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1025
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0966
1729	Solute carrier family 22 member 6	SLC22A6	0.0855
20	Prostaglandin G/H synthase 1	PTGS1	0.0835
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.081
862	Multidrug resistance-associated protein 1	ABCC1	0.0805
118	Organic cation/carnitine transporter 2	SLC22A5	0.0801
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0773
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0762
3941	Amine oxidase [flavin-containing] A	MAOA	0.0741
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0731
6147	Solute carrier family 22 member 3	SLC22A3	0.0727
131	Synaptic vesicular amine transporter	SLC18A2	0.0635
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0602
465	Calmodulin	CALM1	0.06
6106	Cytochrome P450 2C18	CYP2C18	0.0573
833	Organic cation/carnitine transporter 1	SLC22A4	0.057
6142	Solute carrier family 22 member 8	SLC22A8	0.0569
290	Prostaglandin G/H synthase 2	PTGS2	0.0563
1898	Cytochrome P450 1B1	CYP1B1	0.0543
3811	Cytochrome P450 19A1	CYP19A1	0.0539
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0539
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0498
6141	Sodium/bile acid cotransporter	SLC10A1	0.0481
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0478
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0466
124	Histamine H2 receptor	HRH2	0.0466
94	5-hydroxytryptamine 4 receptor	HTR4	0.0443
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0438
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0433
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0433
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0416
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0402
136	Estrogen receptor	ESR1	0.0386
6143	Solute carrier family 22 member 7	SLC22A7	0.0379
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0374
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0372
2164	Multidrug resistance-associated protein 4	ABCC4	0.0369
871	Glucocorticoid receptor	NR3C1	0.0368
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0356
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0341
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0339
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0335
3939	Amine oxidase [flavin-containing] B	MAOB	0.0334
847	Mu-type opioid receptor	OPRM1	0.0331
1024	Solute carrier family 22 member 11	SLC22A11	0.0326
36	Insulin receptor	INSR	0.0325
1656	CYP2B protein	CYP2B	0.0309
1517	Beta-3 adrenergic receptor	ADRB3	0.0306
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0303
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0295
696	Kappa-type opioid receptor	OPRK1	0.0293
6148	Multidrug resistance-associated protein 7	ABCC10	0.0293
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0292
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0288
817	DNA topoisomerase 2-alpha	TOP2A	0.0287
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0284
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.028
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.028
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0278
731	HIV-1 protease	HIV-1 protease	0.0273
3947	Xanthine dehydrogenase/oxidase	XDH	0.0272
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0272
467	Delta-type opioid receptor	OPRD1	0.0271
891	Dihydropteroate synthase	folP	0.027
5359	Dihydropteroate synthase	folP	0.027
7175	Dihydropteroate synthase	sulI	0.027
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0258
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0258
260	Cytochrome P450 51	ERG11	0.025
761	Cytochrome P450 51	ERG11	0.025
3163	Cytochrome P450 51	cyp51	0.025
468	Cytochrome P450 4A11	CYP4A11	0.0247
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0246
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.024
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0235
174	Sigma 1-type opioid receptor	SIGMAR1	0.0235
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0231
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0231
1341	Histamine H3 receptor	HRH3	0.0217
2433	Capsid protein P40	UL80	0.0213
3569	Capsid protein P40	BVRF2	0.0213
4604	Liver carboxylesterase 1	CES1	0.0209
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0207
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0205
683	Potassium transporter	GK0582	0.0203
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0202
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0201
614	Progesterone receptor	PGR	0.0201
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0198
380	Cytochrome P450 17A1	CYP17A1	0.0197
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0197
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0197
3426	Glutamine synthetase	glnA	0.0194
3987	Glutamine synthetase	GLUL	0.0194
244	Angiotensin-converting enzyme	ACE	0.0193
2049	Gastrin/cholecystokinin type B receptor	CCKBR	0.0191
6031	Cytochrome P450 3A43	CYP3A43	0.0189
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0188
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0187
3076	Antigen 85-C	fbpC	0.0187
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0186
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0185
6137	Multidrug resistance-associated protein 6	ABCC6	0.0185
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0181
477	DNA topoisomerase 4 subunit A	parC	0.0181
886	DNA topoisomerase 4 subunit A	parC	0.0181
6226	DNA topoisomerase 4 subunit A	parC	0.0181
6182	Cytochrome P450 2J2	CYP2J2	0.0181
404	DNA gyrase subunit A	gyrA	0.0178
6224	DNA gyrase subunit A	gyrA	0.0178
1178	Adenosine A2a receptor	ADORA2A	0.0176
756	Sex hormone-binding globulin	SHBG	0.0176
161	Tubulin beta chain	TUBB	0.0176
312	Tubulin beta chain	TUB2	0.0176
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0174
6138	Multidrug resistance protein 3	ABCB4	0.0174
1389	Transforming growth factor beta-1	TGFB1	0.0169
6432	Transporter	snf	0.0168
516	Neurotensin receptor type 2	NTSR2	0.0168
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0167
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0167
828	Phenylalanine-4-hydroxylase	PAH	0.0167
3109	Phenylalanine-4-hydroxylase	phhA	0.0167
869	Estrogen receptor beta	ESR2	0.0166
16	Adenosine A1 receptor	ADORA1	0.0162
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0158
482	Glycine receptor subunit alpha-1	GLRA1	0.0157
146	Androgen receptor	AR	0.0156
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0155
705	Glutamate receptor 1	GRIA1	0.0153
921	Glutamate receptor 2	GRIA2	0.015
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.015
923	Glutamate receptor 3	GRIA3	0.0149
4120	NADPH--cytochrome P450 reductase	POR	0.0148
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0148
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0148
2796	Parathion hydrolase	opd	0.0147
6539	Parathion hydrolase	opd	0.0147
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0147
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0146
738	Monocarboxylate transporter 1	SLC16A1	0.0146
232	Corticosteroid-binding globulin	SERPINA6	0.0146
844	Epidermal growth factor receptor	EGFR	0.0145
164	Histamine H4 receptor	HRH4	0.0145
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0144
777	Tumor necrosis factor	TNF	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
3454	Esterase	estA	0.0141
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.014
49	Endothelin B receptor	EDNRB	0.0139
122	P2Y purinoceptor 12	P2RY12	0.0138
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0138
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0138
737	Mineralocorticoid receptor	NR3C2	0.0136
504	Mast/stem cell growth factor receptor	KIT	0.0136
1636	Trace amine-associated receptor 1	TAAR1	0.0134
6136	Multidrug resistance-associated protein 5	ABCC5	0.0132
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0132
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0132
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0131
578	Endothelin-1 receptor	EDNRA	0.0131
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0129
373	Transthyretin	TTR	0.0129
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0129
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0125
275	Arachidonate 5-lipoxygenase	ALOX5	0.0124
2929	(S)-2-haloacid dehalogenase	dhlB	0.0124
2995	(S)-2-haloacid dehalogenase	Not Available	0.0124
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0123
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0123
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0123
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0123
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0123
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0123
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0121
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0119
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0119
3270	Elongation factor G	fusA	0.0119
2808	Chloramphenicol acetyltransferase 3	cat3	0.0119
6014	Cytochrome P450 2A13	CYP2A13	0.0119
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0118
904	Glutathione S-transferase P	GSTP1	0.0117
1192	Sulfotransferase 1A1	SULT1A1	0.0115
818	50S ribosomal protein L10	rplJ	0.0115
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0115
1010	Cytochrome P450 51A1	CYP51A1	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
6102	Arylamine N-acetyltransferase 2	NAT2	0.0113
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0113
6220	Aryl hydrocarbon receptor	AHR	0.0112
1275	Estrogen sulfotransferase	SULT1E1	0.0112
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0111
811	Translocator protein	TSPO	0.011
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.011
70	Type-1 angiotensin II receptor	AGTR1	0.011
2449	Tubulin alpha-3 chain	TUBA1A	0.0108
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0108
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0108
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0107
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
887	DNA gyrase subunit B	gyrB	0.0105
4150	DNA gyrase subunit B	gyrB	0.0105
6225	DNA gyrase subunit B	gyrB	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0104
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0104
1618	High affinity nerve growth factor receptor	NTRK1	0.0103
958	Insulin-like growth factor 1 receptor	IGF1R	0.0102
29	Tubulin beta-1 chain	TUBB1	0.0102
6859	Protein S100-A4	S100A4	0.0101
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0101
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0101
183	Vascular endothelial growth factor A	VEGFA	0.0101
6167	Organic solute transporter subunit beta	OSTB	0.01
952	Dipeptidyl peptidase 4	DPP4	0.01
6166	Organic solute transporter subunit alpha	OSTA	0.01
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.01
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.01
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.01
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.01
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.01
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0098
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0098
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0098
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0098
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0098
1757	Myeloperoxidase	MPO	0.0098
407	Vascular endothelial growth factor receptor 2	KDR	0.0097
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0097
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0097
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0096
6151	Monocarboxylate transporter 10	SLC16A10	0.0096
153	Dopamine beta-hydroxylase	DBH	0.0095
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0095
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0095
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0094
566	Serotransferrin	TF	0.0094
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0094
4122	Histone deacetylase 2	HDAC2	0.0092
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0092
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0092
1629	Transcription factor AP-1	JUN	0.0091
694	Matrix protein 2	M	0.009
672	Prostaglandin F2-alpha receptor	PTGFR	0.009
3810	Catechol O-methyltransferase	COMT	0.009
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0089
33	Cystine/glutamate transporter	SLC7A11	0.0089
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0088
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0086
6085	Fatty acid-binding protein, intestinal	FABP2	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
4773	Deoxycytidine kinase	DCK	0.0085
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0085
3932	Glutathione S-transferase A2	GSTA2	0.0085
273	Apoptosis regulator Bcl-2	BCL2	0.0084
565	Extracellular calcium-sensing receptor	CASR	0.008
4203	Histamine N-methyltransferase	HNMT	0.008
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.008
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0079
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
26	Vascular endothelial growth factor receptor 3	FLT4	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2178	Metabotropic glutamate receptor 5	GRM5	0.0078
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0077
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0077
85	Growth hormone receptor	GHR	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
284	DNA-directed RNA polymerase beta chain	rpoB	0.0076
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0076
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0076
427	Substance-P receptor	TACR1	0.0075
32	Vascular endothelial growth factor receptor 1	FLT1	0.0075
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0074
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0074
2539	Tubulin alpha-1 chain	TUBA4A	0.0074
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0074
233	Potassium channel subfamily K member 2	KCNK2	0.0073
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0072
365	Dihydrofolate reductase	DHFR	0.0072
2381	Dihydrofolate reductase	DFR1	0.0072
2833	Dihydrofolate reductase	Not Available	0.0072
2931	Dihydrofolate reductase	folA	0.0072
3544	Dihydrofolate reductase	folA	0.0072
3682	Dihydrofolate reductase	folA	0.0072
6642	Dihydrofolate reductase	folA	0.0072
6756	Dihydrofolate reductase	dfrA	0.0072
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
1050	Bile salt sulfotransferase	SULT2A1	0.007
6043	Putative G-protein coupled receptor 44	GPR44	0.0069
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
3856	Fibroblast growth factor receptor 3	FGFR3	0.0069
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0069
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0068
823	Fibroblast growth factor receptor 2	FGFR2	0.0068
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
1852	Microtubule-associated protein 2	MAP2	0.0067
5787	Angiopoietin-1 receptor	TEK	0.0067
6020	Aldehyde oxidase	AOX1	0.0067
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0067
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0067
6211	Tubulin epsilon chain	TUBE1	0.0067
6212	Tubulin gamma-1 chain	TUBG1	0.0067
6210	Tubulin delta chain	TUBD1	0.0067
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0065
6070	Nischarin	NISCH	0.0065
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0065
814	Ryanodine receptor 1	RYR1	0.0065
571	Melatonin receptor type 1A	MTNR1A	0.0064
362	Melatonin receptor type 1B	MTNR1B	0.0064
908	Glutathione S-transferase theta-1	GSTT1	0.0064
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0063
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0063
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
4192	DNA topoisomerase 2-beta	TOP2B	0.0062
144	Hemoglobin subunit alpha	HBA1	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
6146	High affinity copper uptake protein 1	SLC31A1	0.0062
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0062
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0062
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0062
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0062
768	FK506-binding protein 1A	FKBP1A	0.0062
295	Carbonic anhydrase 1	CA1	0.0061
751	Potassium channel subfamily K member 6	KCNK6	0.0061
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0061
165	FL cytokine receptor	FLT3	0.006
6097	Protein S100-A2	S100A2	0.006
3809	Estrogen-related receptor gamma	ESRRG	0.006
1810	Protein S100-A1	S100A1	0.006
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0059
65	Matrix metalloproteinase-9	Not Available	0.0059
976	Platelet glycoprotein IX	GP9	0.0059
1830	5'-nucleotidase	NT5E	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
592	Carbonic anhydrase 4	CA4	0.0058
6171	Solute carrier family 28 member 3	SLC28A3	0.0058
5934	Cytochrome P450 26A1	CYP26A1	0.0058
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0058
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0058
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0057
6824	Tyrosine-protein kinase Lyn	LYN	0.0057
3587	Gastrotropin	FABP6	0.0057
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0056
2207	Rhodopsin	RHO	0.0056
723	Cytosolic phospholipase A2	PLA2G4A	0.0056
1374	Natriuretic peptides B	NPPB	0.0056
1827	Gap junction alpha-1 protein	GJA1	0.0056
1908	Vascular cell adhesion protein 1	VCAM1	0.0056
444	Alcohol dehydrogenase 1B	ADH1B	0.0056
172	Potassium channel subfamily K member 1	KCNK1	0.0056
7	Nitric oxide synthase, inducible	NOS2	0.0056
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0055
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0055
459	Retinoic acid receptor RXR-alpha	RXRA	0.0055
6149	Solute carrier family 22 member 10	SLC22A10	0.0055
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0055
6506	Stathmin-4	STMN4	0.0055
357	Carbonic anhydrase 2	CA2	0.0053
594	Thyroxine-binding globulin	SERPINA7	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
517	Alcohol dehydrogenase 1C	ADH1C	0.0052
712	Tubulin alpha chain	TUB1	0.0052
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
1048	Protein S100-A13	S100A13	0.0052
2226	Protein S100-A12	S100A12	0.0052
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0052
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
251	Alcohol dehydrogenase 1A	ADH1A	0.0051
2216	Fibroblast growth factor receptor 4	FGFR4	0.0051
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.005
518	Peroxidase/catalase T	katG	0.005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.005
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.005
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.005
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.005
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
758	Thyroid hormone receptor alpha	THRA	0.0049
3404	Exotoxin A	eta	0.0049
319	Opioid receptor, sigma 1	OPRS1	0.0049
2132	Protein S100-B	S100B	0.0049
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
469	Annexin A1	ANXA1	0.0048
6165	Copper-transporting ATPase 1	ATP7A	0.0048
6163	Copper-transporting ATPase 2	ATP7B	0.0048
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0047
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0047
896	Glutathione S-transferase Mu 1	GSTM1	0.0047
239	Coagulation factor X	F10	0.0046
780	Retinoic acid receptor RXR-gamma	RXRG	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
4784	Beta-mannosidase	manB	0.0046
6695	Beta-mannosidase	BT_0458	0.0046
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0046
3957	Adenosine deaminase	ADA	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
2230	Catalase	CAT	0.0045
3249	Catalase	katA	0.0045
3625	Catalase	katA	0.0045
4539	Catalase	katA	0.0045
4941	Catalase	katB	0.0045
5923	Microtubule-associated protein tau	MAPT	0.0045
5924	Microtubule-associated protein 4	MAP4	0.0045
563	Thyroid peroxidase	TPO	0.0045
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0045
3611	Cytidine deaminase	cdd	0.0045
3707	Cytidine deaminase	cdd	0.0045
4211	Cytidine deaminase	CDA	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
6131	Carbonic anhydrase 14	CA14	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6126	Carbonic anhydrase 7	CA7	0.0044
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
707	72 kDa type IV collagenase	MMP2	0.0044
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0043
3937	Fatty-acid amide hydrolase	FAAH	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
24	Thymidylate synthase	TMP1	0.0043
359	Thymidylate synthase	TYMS	0.0043
2626	Thymidylate synthase	thyA	0.0043
2729	Thymidylate synthase	thyA	0.0043
5352	Thymidylate synthase	THYA	0.0043
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0043
88	Retinoic acid receptor RXR-beta	RXRB	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
1864	RET proto-oncogene	RET	0.0042
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0042
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0042
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0042
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0042
6044	Serum paraoxonase/lactonase 3	PON3	0.0042
4311	tRNA	TRDMT1	0.0041
4325	tRNA	trmD	0.0041
4328	tRNA	trmD	0.0041
4103	Proteasome subunit beta type 2	PSMB2	0.0041
4102	Proteasome subunit beta type 5	PSMB5	0.0041
4101	Proteasome subunit beta type 1	PSMB1	0.0041
125	DNA polymerase beta	POLB	0.0041
84	Nuclear receptor 0B1	NR0B1	0.0041
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
856	Vitamin D3 receptor	VDR	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
3868	Calcineurin subunit B isoform 2	PPP3R2	0.004
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.004
558	Solute carrier family 12 member 1	SLC12A1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
1714	Mitogen-activated protein kinase 3	MAPK3	0.004
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0038
2300	Lysozyme	E	0.0038
3633	Lysozyme	R	0.0038
5597	Lysozyme	17	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
2472	Voltage-gated potassium channel	kcsA	0.0038
6366	Voltage-gated potassium channel	kcsA	0.0038
6501	Fatty acid-binding protein, liver	FABP1	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
595	Fibrinogen alpha chain	FGA	0.0037
992	Protein tyrosine kinase 2 beta	PTK2B	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0037
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0036
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0036
4787	Envelope glycoprotein gp160	env	0.0036
4820	Envelope glycoprotein gp160	env	0.0036
5727	Envelope glycoprotein gp160	env	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
5626	Nucleoside diphosphate kinase B	NME2	0.0036
4210	Toll-like receptor 4	TLR4	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0035
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
229	Retinoic acid receptor beta	RARB	0.0034
2297	Genome polyprotein	Not Available	0.0034
2322	Genome polyprotein	Not Available	0.0034
2694	Genome polyprotein	Not Available	0.0034
2719	Genome polyprotein	Not Available	0.0034
2860	Genome polyprotein	Not Available	0.0034
2928	Genome polyprotein	Not Available	0.0034
3160	Genome polyprotein	Not Available	0.0034
3260	Genome polyprotein	Not Available	0.0034
4783	Genome polyprotein	Not Available	0.0034
5726	Genome polyprotein	Not Available	0.0034
5779	Genome polyprotein	Not Available	0.0034
5867	Genome polyprotein	Not Available	0.0034
6253	Genome polyprotein	Not Available	0.0034
6301	Genome polyprotein	Not Available	0.0034
6380	Genome polyprotein	Not Available	0.0034
6381	Genome polyprotein	Not Available	0.0034
6437	Genome polyprotein	Not Available	0.0034
6520	Genome polyprotein	Not Available	0.0034
6521	Genome polyprotein	Not Available	0.0034
6652	Genome polyprotein	Not Available	0.0034
6734	Genome polyprotein	Not Available	0.0034
6735	Genome polyprotein	Not Available	0.0034
6736	Genome polyprotein	Not Available	0.0034
6737	Genome polyprotein	Not Available	0.0034
6738	Genome polyprotein	Not Available	0.0034
6739	Genome polyprotein	Not Available	0.0034
6744	Genome polyprotein	Not Available	0.0034
6748	Genome polyprotein	Not Available	0.0034
6894	Genome polyprotein	Not Available	0.0034
6898	Genome polyprotein	Not Available	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0034
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0034
861	Choline kinase alpha	CHKA	0.0034
3927	Choline transporter-like protein 3	SLC44A3	0.0034
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0034
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0034
1686	Choline transporter-like protein 1	SLC44A1	0.0034
3926	Choline transporter-like protein 2	SLC44A2	0.0034
769	High-affinity choline transporter 1	SLC5A7	0.0034
700	Choline dehydrogenase, mitochondrial	CHDH	0.0034
3925	Choline transporter-like protein 4	SLC44A4	0.0034
576	Choline O-acetyltransferase	CHAT	0.0034
3922	Phospholipase D2	PLD2	0.0034
3924	Phospholipase D1	PLD1	0.0034
634	Squalene monooxygenase	SQLE	0.0034
7196	Squalene monooxygenase	ERG1	0.0034
730	Retinoic acid receptor alpha	RARA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
162	Retinoic acid receptor gamma-1	RARG	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
702	UMP-CMP kinase	CMPK1	0.0032
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0032
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0032
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0032
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0032
484	Tyrosine-protein kinase ABL2	ABL2	0.0032
1867	Major prion protein	PRNP	0.0032
6459	Glycodelin	PAEP	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
291	Nitric-oxide synthase, endothelial	NOS3	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0031
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0031
199	Monocarboxylate transporter 8	SLC16A2	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1992	Vitamin D-binding protein	GC	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
3437	Eosinophil lysophospholipase	CLC	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.003
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.003
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.003
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.003
267	Plasminogen activator inhibitor 1	SERPINE1	0.003
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
6168	Solute carrier family 22 member 16	SLC22A16	0.0029
5126	Arginase	rocF	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
6218	Pannexin-1	PANX1	0.0029
5294	Nucleoside diphosphate kinase A	NME1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0028
2298	Cytochrome P450-cam	camC	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
54	Prothrombin	F2	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
6221	Steroid hormone receptor ERR1	ESRRA	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6111	DNA polymerase epsilon subunit 4	POLE4	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
6112	DNA polymerase epsilon subunit 3	POLE3	0.0027
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0026
6110	DNA polymerase epsilon subunit 2	POLE2	0.0026
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
293	Gamma-glutamyl hydrolase	GGH	0.0026
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0026
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
268	Adenosine A2b receptor	ADORA2B	0.0026
1648	Elastin	ELN	0.0026
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0026
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0026
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0026
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0026
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0026
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0025
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0025
1268	Neuropeptide S receptor	NPSR1	0.0025
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0025
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0025
76	Nitric-oxide synthase, brain	NOS1	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
340	Apoptotic protease-activating factor 1	APAF1	0.0024
2391	Ferrochelatase	hemH	0.0024
6502	Ferrochelatase	DKFZp686P18130	0.0024
1591	Ferrochelatase, mitochondrial	FECH	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
1650	Heme carrier protein 1	SLC46A1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0023
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0023
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0023
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0023
489	Monocarboxylate transporter 2	SLC16A7	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6073	Potassium channel subfamily K member 9	KCNK9	0.0022
6072	Potassium channel subfamily K member 3	KCNK3	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
4217	Telomerase reverse transcriptase	TERT	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
4785	Ig gamma-1 chain C region	IGHG1	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0022
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0022
825	Arsenical pump-driving ATPase	ASNA1	0.0022
3435	Arsenical pump-driving ATPase	arsA	0.0022
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0021
154	AFG3-like protein 2	AFG3L2	0.0021
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0021
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0021
733	Activin receptor type 1B	ACVR1B	0.0021
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0021
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0021
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0021
395	ALK tyrosine kinase receptor	Not Available	0.0021
298	Renin	REN	0.0021
2091	Endoplasmin	HSP90B1	0.0021
936	Ephrin type-A receptor 2	EPHA2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0021
1243	Cathepsin D	CTSD	0.0021
820	Glycine receptor subunit alpha-2	GLRA2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0021
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0021
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0021
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0021
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0021
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0021
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0021
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0021
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0021
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0021
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0021
6559	Cytochrome c oxidase subunit 2	ctaC	0.0021
6669	Cytochrome c oxidase subunit 2	ctaC	0.0021
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0021
6558	Cytochrome c oxidase subunit 1	ctaD	0.0021
3601	Dihydropteroate synthase 1	folP1	0.0021
3807	Dihydropteroate synthase 1	folP1	0.0021
3808	Dihydropteroate synthase 2	folP2	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
283	SEC14-like protein 2	SEC14L2	0.002
603	DNA polymerase alpha catalytic subunit	POLA1	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6755	Poliovirus receptor	PVR	0.002
292	Activin receptor type-1	ACVR1	0.002
849	Activated CDC42 kinase 1	TNK2	0.002
822	Aldose reductase	AKR1B1	0.002
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
4226	Uridine phosphorylase 2	UPP2	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
2540	Choloylglycine hydrolase	cbh	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
6500	Phospholipase A2	PLA2G1B	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0019
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0019
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0019
297	Adenylate cyclase type 1	ADCY1	0.0019
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0019
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
4225	Uridine phosphorylase 1	UPP1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0018
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
1630	Integrin beta-2	ITGB2	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
413	Amidophosphoribosyltransferase	PPAT	0.0017
2515	Amidophosphoribosyltransferase	purF	0.0017
3714	Amidophosphoribosyltransferase	purF	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0016
106	Cannabinoid receptor 2	CNR2	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0016
735	Alanine aminotransferase 1	GPT	0.0016
3904	Alanine aminotransferase 2	GPT2	0.0016
6228	Nuclear receptor coactivator 1	NCOA1	0.0016
740	Argininosuccinate synthase	ASS1	0.0016
865	Argininosuccinate synthase	ASS1	0.0016
2680	Argininosuccinate synthase	argG	0.0016
3194	Argininosuccinate synthase	argG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0016
661	ADP/ATP translocase 1	SLC25A4	0.0016
3221	Cytochrome c4	cc4	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
6021	Adenosine kinase	ADK	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
277	Purine nucleoside phosphorylase	PNP	0.0015
2870	Purine nucleoside phosphorylase	punA	0.0015
2945	Purine nucleoside phosphorylase	punA	0.0015
4659	Purine nucleoside phosphorylase	TM_1596	0.0015
4825	Purine nucleoside phosphorylase	TTHA1435	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
2021	Thrombomodulin	THBD	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
6316	ADP-ribosylation factor 1	ARF1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
798	Osteocalcin	BGLAP	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
3639	Thymidine phosphorylase	deoA	0.0014
3936	Thymidine phosphorylase	TYMP	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
572	Integrin alpha-L	ITGAL	0.0013
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
369	Coagulation factor VII	F7	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
4498	Ornithine cyclodeaminase	PP3533	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
1295	Fatty acid synthase	FASN	0.0012
5449	Hypothetical gliding protein	mglB	0.0012
5443	UPF0189 protein ymdB	ymdB	0.0012
5440	UPF0067 protein yebR	yebR	0.0012
4705	Manganese catalase	Not Available	0.0012
5439	33 kDa chaperonin	hslO	0.0012
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0012
2720	Copper-containing nitrite reductase	nirK	0.0012
5448	Ribonuclease Z	rnz	0.0012
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0012
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0012
5454	Internalin-A	inlA	0.0012
4608	Putative cytochrome P450	SCO1207	0.0011
4963	Putative cytochrome P450	SCO2884	0.0011
6254	Putative cytochrome P450	SCO6998	0.0011
6042	Prostaglandin reductase 2	PTGR2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
2802	Endoglucanase G	celCCG	0.0011
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0011
5450	Prolyl endopeptidase Pep	pep	0.0011
1792	Tissue-type plasminogen activator	PLAT	0.001
3356	Diaminopimelate decarboxylase	lysA	0.001
597	Dihydropteridine reductase	QDPR	0.001
4771	Dissimilatory copper-containing nitrite reductase	nir	0.001
3274	Hydroxylamine reductase	hcp	0.001
4804	Hydroxylamine reductase	hcp	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
2714	Chorismate mutase	aroH	0.001
4611	Chorismate mutase	aroG	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.001
3399	Limonene-1,2-epoxide hydrolase	limA	0.001
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
5180	L(+)-mandelate dehydrogenase	mdlB	0.0009
577	Argininosuccinate lyase	ASL	0.0009
3500	Putative family 31 glucosidase yicI	yicI	0.0009
4878	Glycoprotein hormones alpha chain	CGA	0.0009
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0009
1072	Granzyme B	GZMB	0.0009
4889	Ig epsilon chain C region	IGHE	0.0009
4877	Beta-mannanase	man	0.0009
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0009
4189	Alpha-galactosidase A	GLA	0.0009
4850	Beta-2-glycoprotein 1	APOH	0.0009
4880	Membrane cofactor protein	CD46	0.0009
4856	CD209 antigen	CD209	0.0009
1354	Beta-glucuronidase	GUSB	0.0009
757	Fusion glycoprotein F0	F	0.0009
4875	Fusion glycoprotein F0	F	0.0009
4869	Major capsid protein	A430L	0.0009
4852	Reticulon-4 receptor	RTN4R	0.0009
4845	ADAM 33	ADAM33	0.0009
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0009
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0009
4721	Beta-1,4-mannanase	manA	0.0009
3352	Structural polyprotein	Not Available	0.0009
3628	Structural polyprotein	Not Available	0.0009
4892	Structural polyprotein	Not Available	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
1615	Chymase	CMA1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
1313	Lactoylglutathione lyase	GLO1	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0008
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3830	Calreticulin	CALR	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4861	Interleukin-6 receptor alpha chain	IL6R	0.0008
793	T-cell surface antigen CD2	CD2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0008
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0008
3837	Cytokine receptor common beta chain	CSF2RB	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
130	Prostacyclin synthase	PTGIS	0.0007
4890	Hemagglutinin	HA	0.0007
6566	Hemagglutinin	Not Available	0.0007
1379	Interleukin-12 subunit beta	IL12B	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6858	Inactive carboxylesterase 4	CES1P1	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
1184	Interferon beta	IFNB1	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0006
554	Low-density lipoprotein receptor	LDLR	0.0006
852	Heparin cofactor 2	SERPIND1	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
1859	Prostatic acid phosphatase	ACPP	0.0006
3444	Cyanovirin-N	Not Available	0.0006
3140	Hemagglutinin-neuraminidase	HN	0.0006
3609	Hemagglutinin-neuraminidase	HN	0.0006
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
4666	Fucose-binding lectin PA-IIL	lecB	0.0005
2372	Bifunctional tail protein	9	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0005
3814	Complement C1r subcomponent	C1R	0.0005
64	Neuraminidase	NA	0.0005
641	Neuraminidase	NA	0.0005
2676	Neuraminidase	NA	0.0005
3026	Neuraminidase	NA	0.0005
3519	Neuraminidase	NA	0.0005
6007	Neuraminidase	NA	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
1439	Lactotransferrin	LTF	0.0005
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0005
5961	Insulin	INS	0.0005
309	Antithrombin-III	SERPINC1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
2430	Chondroitinase B	cslB	0.0004
6307	Ig gamma-2 chain C region	IGHG2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
2581	Chondroitinase AC	cslA	0.0004
6847	Lactase-phlorizin hydrolase	LCT	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
4920	Peroxidase/catalase	katG	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00477 - Chlorpromazine

Targets

Enzymes

Transporters

Carriers

Predictions