DT-Web

7-alpha-hydroxysteroid dehydrogenase


Partner ID 3671
Name 7-alpha-hydroxysteroid dehydrogenase
Synonyms 5681
Gene name hdhA
General function Lipid transport and metabolism
Specific function 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid
Gene sequence + ...

GTGTTTAATTCTGACAACCTGAGACTCGACGGAAAATGCGCCATCATCACAGGTGCGGGTGCAGGTATTGGTAAAGAAATCGCCATTACATTCGCGACAGCTGGCGCATCTGTGGTGGTCAGTGATATTAACGCCGACGCAGCTAACCATGTTGTAGACGAAATTCAACAACTGGGTGGTCAGGCATTTGCCTGCCGTTGTGATATTACTTCCGAACAGGAACTCTCTGCACTGGCAGACTTTGCTATCAGTAAGCTGGGTAAAGTTGATATTCTGGTTAACAACGCCGGTGGCGGTGGACCTAAACCGTTTGATATGCCAATGGCGGATTTTCGCCGTGCTTATGAACTGAATGTGTTTTCTTTTTTCCATCTGTCACAACTTGTTGCGCCAGAAATGGAAAAAAATGGCGGTGGCGTTATTCTGACCATCACTTCTATGGCGGCAGAAAATAAAAATATAAACATGACTTCCTATGCATCATCTAAAGCTGCGGCCAGTCATCTGGTCAGAAATATGGCGTTTGACCTGGGTGAAAAAAATATTCGGGTAAATGGCATTGCGCCGGGGGCAATATTAACCGATGCCCTGAAATCCGTTATTACACCAGAAATTGAACAAAAAATGTTACAGCACACGCCGATCAGACGTCTGGGCCAACCGCAAGATATTGCTAACGCAGCGCTGTTCCTTTGCTCGCCTGCTGCGAGCTGGGTAAGCGGACAAATTCTCACCGTCTCCGGTGGTGGGGTACAGGAGCTCAATTAA
Protein sequence + ...

MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQELSALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAENKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQILTVSGGGVQELN
GO Classification
function
catalytic activity
oxidoreductase activity
process
physiological process
metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01907 Nicotinamide-Adenine-Dinucleotide
DB02123 Glycochenodeoxycholic Acid

Associated as Prediction

Id Name
DB00091 Cyclosporine
DB00142 L-Glutamic Acid
DB00143 Glutathione
DB00157 NADH
DB00162 Vitamin A
DB00171 Adenosine triphosphate
DB00175 Pravastatin
DB00197 Troglitazone
DB00199 Erythromycin
DB00206 Reserpine
DB00220 Nelfinavir
DB00224 Indinavir
DB00227 Lovastatin
DB00262 Carmustine
DB00279 Liothyronine
DB00286 Conjugated Estrogens
DB00291 Chlorambucil
DB00328 Indomethacin
DB00336 Nitrofurazone
DB00345 Aminohippurate
DB00390 Digoxin
DB00396 Progesterone
DB00421 Spironolactone
DB00435 Nitric Oxide
DB00451 Levothyroxine
DB00468 Quinine
DB00477 Chlorpromazine
DB00501 Cimetidine
DB00503 Ritonavir
DB00536 Guanidine
DB00541 Vincristine
DB00559 Bosentan
DB00563 Methotrexate
DB00570 Vinblastine
DB00577 Valaciclovir
DB00584 Enalapril
DB00609 Ethionamide
DB00624 Testosterone
DB00635 Prednisone
DB00641 Simvastatin
DB00655 Estrone
DB00661 Verapamil
DB00669 Sumatriptan
DB00675 Tamoxifen
DB00688 Mycophenolate mofetil
DB00693 Fluorescein
DB00694 Daunorubicin
DB00727 Nitroglycerin
DB00728 Rocuronium
DB00741 Hydrocortisone
DB00742 Mannitol
DB00755 Tretinoin
DB00756 Hexachlorophene
DB00783 Estradiol
DB00787 Acyclovir
DB00788 Naproxen
DB00822 Disulfiram
DB00845 Clofazimine
DB00860 Prednisolone
DB00887 Bumetanide
DB00898 Ethanol
DB00908 Quinidine
DB00917 Dinoprostone
DB00950 Fexofenadine
DB00951 Isoniazid
DB00977 Ethinyl Estradiol
DB00997 Doxorubicin
DB01009 Ketoprofen
DB01016 Glyburide
DB01024 Mycophenolic acid
DB01026 Ketoconazole
DB01032 Probenecid
DB01045 Rifampin
DB01050 Ibuprofen
DB01051 Novobiocin
DB01076 Atorvastatin
DB01092 Ouabain
DB01098 Rosuvastatin
DB01124 Tolbutamide
DB01174 Phenobarbital
DB01183 Naloxone
DB01213 Fomepizole
DB01229 Paclitaxel
DB01232 Saquinavir
DB01234 Dexamethasone
DB01396 Digitoxin
DB01536 4-Androstenedione
DB01561 Androstanedione
DB01583 Liotrix
DB01586 Ursodeoxycholic acid
DB01612 Amyl Nitrite
DB01644 3,6-Dihydroxy-Xanthene-9-Propionic Acid
DB01677 Fumarate
DB01691 Indole Naphthyridinone
DB01693 Ribavirin Monophosphate
DB01694 D-tartaric acid
DB01708 Dehydroepiandrosterone
DB01711 2,3,4,5,6-Pentafluorobenzyl Alcohol
DB01713 Udp-Alpha-D-Xylopyranose
DB01727 Isocitric Acid
DB01752 S-Adenosyl-L-Homocysteine
DB01769 Double Oxidized Cysteine
DB01792 Adenylyl-3'-5'-Phospho-Uridine-3'-Monophosphate
DB01848 Isocitrate Calcium Complex
DB01854 5-Bromonicotinamide
DB01861 Glucose-Uridine-C1,5'-Diphosphate
DB01865 3-(6-Aminopyridin-3-Yl)-N-Methyl-N-[(1-Methyl-1h-Indol-2-Yl)Methyl]Acrylamide
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01971 trans-urocanic acid
DB01992 Coenzyme A
DB02007 Alpha-D-Glucose-6-Phosphate
DB02059 Adenosine-5-Diphosphoribose
DB02111 3-Hydroxyisoxazole-4-Carboxylic Acid
DB02115 Daidzin
DB02123 Glycochenodeoxycholic Acid
DB02131 N-1-Methylheptylformamide
DB02147 Cyclo-Tetrametavanadate
DB02153 3-Sulfinoalanine
DB02187 Equilin
DB02190 2-Oxalosuccinic Acid
DB02196 Uridine-Diphosphate-N-Acetylgalactosamine
DB02205 6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One
DB02212 Pyrophosphate 2-
DB02234 Ethylisothiourea
DB02249 2-Ethoxyethanol
DB02263 Glyceraldehyde-3-Phosphate
DB02323 EM-1745
DB02329 Carbenoxolone
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02379 Beta-D-Glucose
DB02383 Tolrestat
DB02401 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid
DB02421 Uridine-5'-Diphosphate-Mannose
DB02481 N-Benzylformamide
DB02483 Etheno-Nad
DB02553 Glutathionylspermidine Disulfide
DB02592 Carbaphosphonate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB02621 Latrunculin A
DB02637 Oxaloacetate Ion
DB02659 Cholic Acid
DB02691 N-Cholylglycine
DB02701 Nicotinamide
DB02703 Fusidic Acid
DB02721 4-Iodopyrazole
DB02757 Pyrazole
DB02772 Sucrose
DB02790 Phenyl-Uridine-5'-Diphosphate
DB02820 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
DB02822 Para-Bromobenzyl Alcohol
DB02854 Aetiocholanolone
DB02871 3-Butylthiolane 1-Oxide
DB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol
DB02901 Dihydrotestosterone
DB02937 Gamma-Arsono-Beta, Gamma-Methyleneadenosine-5'-Diphosphate
DB02990 C16-Fatty-Acyl-Substrate-Mimic
DB03014 Heme
DB03020 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
DB03030 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole
DB03041 Udp-Glucuronic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03061 (R)-N-(1-Methyl-Hexyl)-Formamide
DB03070 Selenazole-4-Carboxyamide-Adenine Dinucleotide
DB03095 Tetramethylammonium Ion
DB03147 Flavin-Adenine Dinucleotide
DB03161 Thymidine-5'-Diphospho-Beta-D-Xylose
DB03162 4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid
DB03169 (S)-Hmg-Coa
DB03192 3r-Hydroxydecanoyl-Coa
DB03211 (3-Formyl-but-3-Enyl)-Phosphonic Acid
DB03216 (1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine
DB03226 Trifluoroethanol
DB03227 Nicotinamide Mononucleotide
DB03229 2-Oxo-4-Methylpentanoic Acid
DB03247 Riboflavin Monophosphate
DB03273 3'-Oxo-Adenosine
DB03310 Oxidized Glutathione Disulfide
DB03323 Maltose
DB03331 N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
DB03345 Beta-Mercaptoethanol
DB03382 S-Oxy Cysteine
DB03397 Uridine-Diphosphate-N-Acetylglucosamine
DB03431 Adenosine-5'-Diphosphate
DB03435 Uridine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03478 2'-O-Acetyl Adenosine-5-Diphosphoribose
DB03499 Malate Ion
DB03501 Uridine Diphosphate Galactose
DB03518 (R)-Mevalonate
DB03534 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide
DB03559 Cyclohexylformamide
DB03589 Alpha-Ketomalonic Acid
DB03612 3-Hydroxybutyryl-Coenzyme A
DB03619 Deoxycholic Acid
DB03639 1-Guanidinium-7-Aminoheptane
DB03680 Tartronate
DB03703 Cyclohexanol
DB03704 12-Hydroxydodecanoic Acid
DB03723 2'-Deoxy-Thymidine-Beta-L-Rhamnose
DB03751 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose
DB03769 D-Eritadenine
DB03785 (3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
DB03811 Histidinol
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03867 Meta-Nitro-Tyrosine
DB03893 Thionicotinamide-Adenine-Dinucleotide
DB03940 Oxamic Acid
DB03948 6-Chloropurine Riboside, 5'-Monophosphate
DB03969 3-Acetyl Pyridine Adenine Dinucleotide
DB04023 Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester
DB04030 1,3,4,9-Tetrahydro-2-(Hydroxybenzoyl)-9-[(4-Hydroxyphenyl)Methyl]-6-Methoxy-2h-Pyrido[3,4-B]Indole
DB04065 N-Cyclopentyl-N-Cyclobutylformamide
DB04071 Cpad
DB04077 Glycerol
DB04097 Uridine-5'-Diphosphate-4-Deoxy-4-Fluoro-Alpha-D-Galactose
DB04099 Deamido-Nad+
DB04105 N-Heptylformamide
DB04113 N-Formylpiperidine
DB04122 Beta-D-Glucose-6-Phosphate
DB04137 Guanosine-5'-Triphosphate
DB04153 S-Hydroxymethyl Glutathione
DB04160 Diphosphate
DB04200 Matairesinol
DB04267 Dipicolinic Acid
DB04272 Citric Acid
DB04279 3-Isopropylmalic Acid
DB04289 Genz-10850
DB04312 2,3-Difluorobenzyl Alcohol
DB04348 Taurocholic Acid
DB04355 Uridine-5'-Monophosphate Glucopyranosyl-Monophosphateester
DB04381 Crotonaldehyde
DB04393 Diclosan
DB04401 [Formylmethyl]Trimethyl-Ammonium, N,N,N-Trimethylammonium Acetaldehyde
DB04447 1,4-Dithiothreitol
DB04448 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene
DB04477 N-1,2,3,4-Tetrahydronaphth-1-Yl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
DB04478 Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
DB04522 Phosphonoserine
DB04555 Cytidine-5'-Diphosphate
DB04566 Inosinic Acid
DB04573 Estriol
DB04630 Aldosterone
DB04640 Naphthalene-2,6-disulfonic acid
DB04641 3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID
DB04786 Suramin
DB06710 Methyltestosterone
DB06770 Benzyl alcohol
DB07040 2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
DB07041 N-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-7-yl)-2-methylpropyl]-4-phenoxybenzamide
DB07042 7-amino-2-tert-butyl-4-{[2-(1H-imidazol-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidine-6-carboxamide
DB07043 7-amino-2-tert-butyl-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
DB07090 (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07123 N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
DB07155 (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE
DB07178 5-PENTYL-2-PHENOXYPHENOL
DB07188 (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07192 (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07222 (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07287 2-(2,4-DICHLOROPHENOXY)-5-(PYRIDIN-2-YLMETHYL)PHENOL
DB07347 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
DB07393 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE
DB07714 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID
DB08265 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL
DB08604 TRICLOSAN
DB08605 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
DB08834 Tauroursodeoxycholic acid
DB08836 Temocapril
DB08860 Pitavastatin
DB08893 Mirabegron
DB08901 Ponatinib
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