DT-Web

DB08834 - Tauroursodeoxycholic acid


Identification
Name Tauroursodeoxycholic acid
Accession Number DB08834
Type small molecule
Description Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxycholic acid, on the other hand, is produced abundantly in bears and has been used for centuries as a natural remedy in some Asian countries. It is approved in Italy and Turkey for the treatment of cholesterol gallstones and is an investigational drug in China, Unites States, and Italy. Tauroursodeoxycholic acid is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. The only completed clinical trial thus far is a phase III clinical trial comparing tauroursodeoxycholic acid and ursofalk in PBC adult patients, but as of June 2013 no results of this trial have been published.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 499.704
Groups approved
Monoisotopic Weight 499.296758867
Pharmacology
Indication Used in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
Mechanism of action Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is naturally produced in the body. In patients with properly functioning gallbladders, both of these bile acids inhibit liver cholesterol secretion and synthesis as well as intestinal cholesterol absorption allowing for the promotion of cholesterol gallstone dissolution. The mechanism of action of tauroursodeoxycholic acid in the other conditions is still being investigated.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Enzymes


Cytochrome P450 3A1
Name Cytochrome P450 3A1
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available
Cytochrome P450 3A2
Name Cytochrome P450 3A2
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2A1
Name Cytochrome P450 2A1
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2A2
Name Cytochrome P450 2A2
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2B1
Name Cytochrome P450 2B1
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2B2
Name Cytochrome P450 2B2
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2B9
Name Cytochrome P450 2B9
Gene Name Not Available
Actions inducer
References
  • Paolini M, Pozzetti L, Piazza F, Cantelli-Forti G, Roda A: Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Hepatology. 1999 Sep;30(3):730-9. - Pubmed
DTHybrid score Not Available

Transporters


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions Not Available
References
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ: Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. - Pubmed
DTHybrid score 0.2118
Cystine/glutamate transporter
Name Cystine/glutamate transporter
Gene Name SLC7A11
Actions Not Available
References
  • Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. - Pubmed
DTHybrid score 0.2488

Predictions


Id Partner name Gene Name Score
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0533
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0487
38 Cystinosin CTNS 0.0485
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0485
1588 Multidrug resistance protein 1 ABCB1 0.0468
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0467
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0372
776 Bile salt export pump ABCB11 0.0345
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.033
4512 Cytochrome P450 3A4 CYP3A4 0.0318
6141 Sodium/bile acid cotransporter SLC10A1 0.0311
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0295
4118 Cytochrome P450 3A5 CYP3A5 0.0294
587 Serum albumin ALB 0.0286
6151 Monocarboxylate transporter 10 SLC16A10 0.0282
862 Multidrug resistance-associated protein 1 ABCC1 0.0271
6024 Cytochrome P450 1A1 CYP1A1 0.0259
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0258
6142 Solute carrier family 22 member 8 SLC22A8 0.0257
4200 Cytochrome P450 1A2 CYP1A2 0.0253
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0242
2164 Multidrug resistance-associated protein 4 ABCC4 0.0241
4757 Cytochrome P450 2C9 CYP2C9 0.0237
6016 Cytochrome P450 2C19 CYP2C19 0.0222
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0218
4924 Cytochrome P450 2C8 CYP2C8 0.0216
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0197
3587 Gastrotropin FABP6 0.0196
1729 Solute carrier family 22 member 6 SLC22A6 0.0187
1650 Heme carrier protein 1 SLC46A1 0.0177
6145 Solute carrier family 22 member 1 SLC22A1 0.0175
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0168
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0168
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0163
6143 Solute carrier family 22 member 7 SLC22A7 0.016
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0154
290 Prostaglandin G/H synthase 2 PTGS2 0.0154
6107 Cytochrome P450 3A7 CYP3A7 0.0152
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0147
4119 Cytochrome P450 2D6 CYP2D6 0.0131
20 Prostaglandin G/H synthase 1 PTGS1 0.013
6167 Organic solute transporter subunit beta OSTB 0.0128
275 Arachidonate 5-lipoxygenase ALOX5 0.0128
6166 Organic solute transporter subunit alpha OSTA 0.0128
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0126
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0122
738 Monocarboxylate transporter 1 SLC16A1 0.012
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0116
904 Glutathione S-transferase P GSTP1 0.0116
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0115
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.011
1024 Solute carrier family 22 member 11 SLC22A11 0.011
244 Angiotensin-converting enzyme ACE 0.0108
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0104
6030 Cytochrome P450 2B6 CYP2B6 0.0103
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0101
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
136 Estrogen receptor ESR1 0.0092
6148 Multidrug resistance-associated protein 7 ABCC10 0.0092
871 Glucocorticoid receptor NR3C1 0.0088
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0083
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0081
737 Mineralocorticoid receptor NR3C2 0.0076
756 Sex hormone-binding globulin SHBG 0.0074
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.007
118 Organic cation/carnitine transporter 2 SLC22A5 0.0068
731 HIV-1 protease HIV-1 protease 0.0067
6013 Cytochrome P450 2E1 CYP2E1 0.0066
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
146 Androgen receptor AR 0.0064
869 Estrogen receptor beta ESR2 0.0064
594 Thyroxine-binding globulin SERPINA7 0.006
758 Thyroid hormone receptor alpha THRA 0.0056
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0053
380 Cytochrome P450 17A1 CYP17A1 0.0051
5718 Cytochrome P450 2A6 CYP2A6 0.0051
6144 Solute carrier family 22 member 2 SLC22A2 0.005
346 Thyroid hormone receptor beta-1 THRB 0.005
3811 Cytochrome P450 19A1 CYP19A1 0.0049
833 Organic cation/carnitine transporter 1 SLC22A4 0.0048
1898 Cytochrome P450 1B1 CYP1B1 0.0046
341 5-hydroxytryptamine 3 receptor HTR3A 0.0046
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0044
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0044
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0044
469 Annexin A1 ANXA1 0.0042
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
232 Corticosteroid-binding globulin SERPINA6 0.004
373 Transthyretin TTR 0.0038
6136 Multidrug resistance-associated protein 5 ABCC5 0.0037
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0036
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0036
468 Cytochrome P450 4A11 CYP4A11 0.0035
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0034
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
1912 Excitatory amino acid transporter 1 SLC1A3 0.0034
4019 Excitatory amino acid transporter 4 SLC1A6 0.0034
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0034
4026 Aspartyl aminopeptidase DNPEP 0.0034
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0034
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0034
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0034
4016 Excitatory amino acid transporter 5 SLC1A7 0.0034
199 Monocarboxylate transporter 8 SLC16A2 0.0034
4017 5-oxoprolinase OPLAH 0.0034
1047 Excitatory amino acid transporter 2 SLC1A2 0.0034
922 Glutamate receptor 4 GRIA4 0.0034
664 Glutamate decarboxylase 2 GAD2 0.0034
3890 Glutamate decarboxylase 2 GAD2 0.0034
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0034
4020 Glutamyl aminopeptidase ENPEP 0.0034
4027 Glutamate receptor delta-1 subunit GRID1 0.0034
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0034
927 Metabotropic glutamate receptor 8 GRM8 0.0034
925 Metabotropic glutamate receptor 4 GRM4 0.0034
926 Metabotropic glutamate receptor 7 GRM7 0.0034
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0034
4018 Glutamate receptor delta-2 subunit GRID2 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0033
511 5-hydroxytryptamine 1F receptor HTR1F 0.0033
1291 cAMP response element-binding protein CREB1 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0031
3941 Amine oxidase [flavin-containing] A MAOA 0.0031
625 Glutamate carboxypeptidase 2 FOLH1 0.0031
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.003
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0029
5 Glutaminase liver isoform, mitochondrial GLS2 0.0029
917 Glutaminase kidney isoform, mitochondrial GLS 0.0029
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0029
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0029
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0029
5261 Phosphoribosylformylglycinamidine synthase purL 0.0029
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0029
6031 Cytochrome P450 3A43 CYP3A43 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
665 Phosphoserine aminotransferase PSAT1 0.0028
4652 Phosphoserine aminotransferase serC 0.0028
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0028
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0028
420 Glutamate decarboxylase 1 GAD1 0.0028
3900 Glutamate decarboxylase 1 GAD1 0.0028
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0028
916 Metabotropic glutamate receptor 1 GRM1 0.0028
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0027
923 Glutamate receptor 3 GRIA3 0.0027
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0027
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0027
1671 Excitatory amino acid transporter 3 SLC1A1 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0026
3877 Growth-inhibiting protein 18 GIG18 0.0026
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0026
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0026
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0026
426 Aspartate aminotransferase, mitochondrial GOT2 0.0026
763 Tyrosine aminotransferase TAT 0.0025
5493 Tyrosine aminotransferase Not Available 0.0025
6106 Cytochrome P450 2C18 CYP2C18 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
492 Histamine H1 receptor HRH1 0.0025
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0024
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
1630 Integrin beta-2 ITGB2 0.0024
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0024
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
976 Platelet glycoprotein IX GP9 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
705 Glutamate receptor 1 GRIA1 0.0023
3923 Cholinesterase BCHE 0.0023
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0023
3426 Glutamine synthetase glnA 0.0022
3987 Glutamine synthetase GLUL 0.0022
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0022
6085 Fatty acid-binding protein, intestinal FABP2 0.0022
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0021
320 5-hydroxytryptamine 1A receptor HTR1A 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0019
6137 Multidrug resistance-associated protein 6 ABCC6 0.0019
2021 Thrombomodulin THBD 0.0018
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
572 Integrin alpha-L ITGAL 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0018
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0018
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0018
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0017
921 Glutamate receptor 2 GRIA2 0.0017
4122 Histone deacetylase 2 HDAC2 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
5934 Cytochrome P450 26A1 CYP26A1 0.0015
6218 Pannexin-1 PANX1 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
6147 Solute carrier family 22 member 3 SLC22A3 0.0015
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0015
1010 Cytochrome P450 51A1 CYP51A1 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0014
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
6042 Prostaglandin reductase 2 PTGR2 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
5818 Folate receptor alpha FOLR1 0.0013
6220 Aryl hydrocarbon receptor AHR 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0013
6043 Putative G-protein coupled receptor 44 GPR44 0.0012
273 Apoptosis regulator Bcl-2 BCL2 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
260 Cytochrome P450 51 ERG11 0.0012
761 Cytochrome P450 51 ERG11 0.0012
3163 Cytochrome P450 51 cyp51 0.0012
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0012
284 DNA-directed RNA polymerase beta chain rpoB 0.0012
5773 DNA-directed RNA polymerase beta chain rpoB 0.0012
293 Gamma-glutamyl hydrolase GGH 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
2540 Choloylglycine hydrolase cbh 0.0011
1313 Lactoylglutathione lyase GLO1 0.0011
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
2981 Phospholipase A2, membrane associated PLA2G2A 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
3810 Catechol O-methyltransferase COMT 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0009
952 Dipeptidyl peptidase 4 DPP4 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0008
6500 Phospholipase A2 PLA2G1B 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
6020 Aldehyde oxidase AOX1 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
24 Thymidylate synthase TMP1 0.0008
359 Thymidylate synthase TYMS 0.0008
2626 Thymidylate synthase thyA 0.0008
2729 Thymidylate synthase thyA 0.0008
5352 Thymidylate synthase THYA 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
365 Dihydrofolate reductase DHFR 0.0007
2381 Dihydrofolate reductase DFR1 0.0007
2833 Dihydrofolate reductase Not Available 0.0007
2931 Dihydrofolate reductase folA 0.0007
3544 Dihydrofolate reductase folA 0.0007
3682 Dihydrofolate reductase folA 0.0007
6642 Dihydrofolate reductase folA 0.0007
6756 Dihydrofolate reductase dfrA 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
824 Sodium-dependent serotonin transporter SLC6A4 0.0005
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