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Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase


Partner ID 210
Name Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
Synonyms 619
Gene name EPRS
General function Translation, ribosomal structure and biogenesis
Specific function Not Available
Gene sequence + ...

ATGGAACATACTGAGATTGATCACTGGTTGGAGTTCAGTGCTACAAAATTATCTTCATGTGATTCCTTTACTTCTACAATTAATGAACTCAATCATTGCCTGTCTCTGAGAACATACTTAGTTGGAAACTCCTTGAGTTTAGCAGATTTATGTGTTTGGGCCACCCTAAAAGGAAATGCTGCCTGGCAAGAACAGTTGAAACAGAAGAAAGCTCCAGTTCATGTAAAACGTTGGTTTGGCTTTCTTGAAGCCCAGCAGGCCTTCCAGTCAGTAGGTACCAAGTGGGATGTTTCAACAACCAAAGCTCGAGTGGCACCTGAGAAAAAGCAAGATGTTGGGAAATTTGTTGAGCTTCCAGGTGCGGAGATGGGAAAGGTTACCGTCAGATTTCCTCCAGAGGCCAGTGGTTACTTACACATTGGGCATGCAAAAGCTGCTCTTCTGAACCAGCACTACCAGGTTAACTTTAAAGGGAAACTGATCATGAGATTTGATGACACAAATCCTGAAAAAGAAAAGGAAGATTTTGAGAAGGTTATCTTGGAAGATGTTGCAATGTTGCATATCAAACCAGATCAATTTACTTATACTTCGGATCATTTTGAAACTATAATGAAGTATGCAGAGAAGCTAATTCAAGAAGGGAAGGCTTATGTGGATGATACTCCTGCTGAACAGATGAAAGCAGAACGTGAGCAGAGGATAGAATCTAAACATAGAAAAAACCCTATTGAGAAGAATCTACAAATGTGGGAAGAAATGAAAAAAGGGAGCCAGTTTGGTCACTCCTGTTGTTTGCGAGCAAAAATTGACATGAGTAGTAACAATGGATGCATGAGAGATCCAACCCTTTATCGCTGCAAAATTCAACCACATCCAAGAACTGGAAATAAATACAATGTTTATCCAACATATGATTTTGCCTGCCCCATAGTTGACAGCATCGAAGGTGTTACACATGCCCTGAGAACAACAGAATACCATGACAGAGATGAGCAGTTTTACTGGATTATTGAAGCTTTAGGCATAAGAAAACCATATATTTGGGAATATAGTCGGCTAAATCTCAACAACACAGTGCTATCCAAAAGAAAACTCACATGGTTTGTCAATGAAGGACTAGTAGATGGATGGGATGACCCAAGATTTCCTACGGTTCGTGGTGTACTGAGAAGAGGGATGACAGTTGAAGGACTGAAACAGTTTATTGCTGCTCAGGGCTCCTCACGTTCAGTCGTGAACATGGAGTGGGACAAAATCTGGGCGTTTAACAAAAAGGTTATTGACCCAGTGGCTCCACGATATGTTGCATTACTGAAGAAAGAAGTGATCCCAGTGAATGTACCTGAAGCTCAGGAGGAGATGAAAGAAGTAGCCAAACACCCAAAGAATCCTGAGGTTGGCTTGAAGCCTGTGTGGTATAGTCCCAAAGTTTTCATTGAAGGTGCTGATGCAGAGACTTTTTCGGAGGGTGAGATGGTTACATTTATAAATTGGGGCAACCTCAACATTACAAAAATACACAAAAATGCAGATGGAAAAATCATATCTCTTGATGCAAAGTTTAATTTGGAAAACAAAGACTACAAGAAAACCACTAAGGTCACTTGGCTTGCAGAGACTACACATGCTCTTCCTATTCCAGTAATCTGTGTCACTTATGAGCACTTGATCACAAAGCCAGTGCTAGGAAAAGACGAGGACTTTAAGCAGTATGTCAACAAGAACAGTAAGCATGAAGAGCTAATGCTAGGGGATCCCTGCCTTAAGGATTTGAAAAAAGGAGATATTATACAACTCCAGAGAAGAGGATTCTTCATATGTGATCAACCTTATGAACCTGTTAGCCCATATAGTTGCAAGGAAGCCCCGTGTGTTTTGATATACATTCCTGATGGGCACACAAAGGAAATGCCAACATCAGGGTCAAAGGAAAAGACCAAAGTAGAAGCCACAAAAAATGAGACCTCTGCTCCTTTTAAGGAAAGACCAACACCTTCTCTGAATAATAATTGTACTACATCTGAGGATTCCTTGGTCCTTTACAATAGAGTGGCTGTTCAAGGAGATGTGGTTCGTGAATTAAAAGCCAAGAAAGCACCAAAGGAAGATGTAGATGCAGCTGTAAAACAGCTTTTGTCTTTGAAAGCTGAATATAAGGAGAAAACTGGCCAGGAATATAAACCTGGAAACCCTCCTGCTGAAATAGGACAGAATATTTCTTCTAATTCCTCAGCAAGTATTCTGGAAAGTAAATCTCTGTATGATGAAGTTGCTGCACAAGGGGAGGTGGTTCGTAAGCTAAAAGCTGAAAAATCCCCTAAGGCTAAAATAAATGAAGCTGTAGAATGCTTACTGTCCCTGAAGGCTCAGTATAAAGAAAAAACTGGGAAGGAGTACATACCTGGTCAGCCCCCATTATCTCAAAGTTCGGATTCAAGCCCAACCAGAAATTCTGAACCTGCTGGTTTAGAAACACCAGAAGCGAAAGTACTTTTTGACAAAGTAGCTTCTCAAGGGGAAGTAGTTCGGAAACTTAAAACTGAAAAAGCCCCTAAGGATCAAGTAGATATAGCTGTTCAAGAACTCCTTCAGCTAAAGGCACAGTACAAGTCTTTGATAGGAGTAGAGTATAAGCCTGTGTCGGCCACTGGAGCTGAGGACAAAGATAAGAAGAAGAAAGAAAAAGAAAATAAATCTGAAAAGCAGAATAAGCCTCAGAAACAAAATGATGGCCAAAGGAAAGACCCTTCTAAAAACCAAGGAGGTGGGCTCTCATCAAGTGGAGCAGGAGAAGGGCAGGGGCCTAAGAAACAGACCAGGTTGGGTCTTGAGGCAAAAAAAGAAGAAAATCTTGCTGATTGGTATTCTCAGGTCATCACAAAGTCAGAAATGATTGAATACCATGACATAAGTGGCTGTTATATTCTTCGTCCCTGGGCCTATGCCATTTGGGAAGCCATCAAGGACTTTTTTGATGCTGAGATCAAGAAACTTGGTGTTGAAAACTGCTACTTCCCCATGTTTGTGTCTCAAAGTGCATTAGAGAAAGAGAAGACTCATGTTGCTGACTTTGCCCCAGAGGTTGCTTGGGTTACAAGATCTGGCAAAACCGAGCTGGCAGAACCAATTGCCATTCGTCCTACTAGTGAAACAGTAATGTATCCTGCATATGCAAAATGGGTACAATCACACAGAGACCTGCCCATCAAGCTCAATCAGTGGTGCAATGTGGTGCGTTGGGAATTCAAGCATCCTCAGCCTTTCCTACGTACTCGTGAATTTCTTTGGCAGGAAGGGCACAGTGCTTTTGCTACCATGGAAGAGGCAGCGGAAGAGGTCTTGCAGATACTTGACTTATATGCTCAGGTATATGAAGAACTCCTGGCAATTCCTGTTGTTAAAGGAAGAAAGACGGAAAAGGAAAAATTTGCAGGAGGAGACTATACAACTACAATAGAAGCATTTATATCTGCTAGTGGAAGAGCTATCCAGGGAGGAACATCACATCATTTAGGGCAGAATTTTTCCAAAATGTTTGAAATCGTTTTTGAAGATCCAAAGATACCAGGAGAGAAGCAATTTGCCTATCAAAACTCCTGGGGCCTGACAACTCGAACTATTGGTGTTATGACCATGGTTCATGGGGACAACATGGGTTTAGTATTACCACCCCGTGTAGCATGTGTTCAGGTGGTGATTATTCCTTGTGGCATTACCAATGCACTTTCTGAAGAAGACAAAGAAGCGCTGATTGCAAAATGCAATGATTATCGAAGGCGATTACTCAGTGTTAACATCCGCGTTAGAGCTGATTTACGAGATAATTATTCTCCAGGTTGGAAATTCAATCACTGGGAGCTCAAGGGAGTTCCCATTAGACTTGAAGTTGGGCCACGTGATATGAAGAGCTGTCAGTTTGTAGCCGTCAGACGAGATACTGGAGAAAAGCTGACAGTTGCTGAAAATGAGGCAGAGACTAAACTTCAAGCTATTTTGGAAGACATCCAGGTCACCCTTTTCACAAGGGCTTCTGAAGACCTTAAGACTCATATGGTTGTGGCTAATACAATGGAAGACTTTCAGAAGATACTAGATTCTGGAAAGATTGTTCAGATTCCATTCTGTGGGGAAATTGACTGTGAGGACTGGATCAAAAAGACCACTGCCAGGGATCAAGATCTTGAACCTGGTGCTCCATCCATGGGAGCTAAAAGCCTTTGCATCCCCTTCAAACCACTCTGTGAACTGCAGCCTGGAGCCAAATGTGTCTGTGGCAAGAACCCTGCCAAGTACTACACCTTATTTGGTCGCAGCTACTGA
Protein sequence + ...

MEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIESKHRKNPIEKNLQMWEEMKKGSQFGHSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKFNLENKDYKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPFKERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRRRLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY
GO Classification
component
cell
intracellular
cytoplasm
function
adenyl nucleotide binding
proline-tRNA ligase activity
ATP binding
glutamate-tRNA ligase activity
binding
nucleotide binding
catalytic activity
ligase activity
ligase activity, forming phosphoric ester bonds
RNA ligase activity
tRNA ligase activity
purine nucleotide binding
process
RNA metabolism
tRNA metabolism
tRNA aminoacylation
tRNA aminoacylation for protein translation
macromolecule biosynthesis
prolyl-tRNA aminoacylation
physiological process
protein biosynthesis
glutamyl-tRNA aminoacylation
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
metabolism
cellular metabolism
macromolecule metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00142 L-Glutamic Acid
DB00172 L-Proline
DB02510 '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine
DB02684 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine
DB03376 '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine

Associated as Prediction

Id Name
DB00036 Coagulation factor VIIa
DB00055 Drotrecogin alfa
DB00082 Pegvisomant
DB00089 Capromab
DB00091 Cyclosporine
DB00100 Coagulation Factor IX
DB00114 Pyridoxal Phosphate
DB00116 Tetrahydrofolic acid
DB00117 L-Histidine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00123 L-Lysine
DB00125 L-Arginine
DB00126 Vitamin C
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00139 Succinic acid
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00156 L-Threonine
DB00157 NADH
DB00160 L-Alanine
DB00161 L-Valine
DB00163 Vitamin E
DB00167 L-Isoleucine
DB00170 Menadione
DB00171 Adenosine triphosphate
DB00172 L-Proline
DB00174 L-Asparagine
DB00175 Pravastatin
DB00193 Tramadol
DB00228 Enflurane
DB00230 Pregabalin
DB00237 Butabarbital
DB00241 Butalbital
DB00273 Topiramate
DB00279 Liothyronine
DB00293 Raltitrexed
DB00306 Talbutal
DB00312 Pentobarbital
DB00313 Valproic Acid
DB00333 Methadone
DB00345 Aminohippurate
DB00392 Ethopropazine
DB00415 Ampicillin
DB00418 Secobarbital
DB00454 Meperidine
DB00463 Metharbital
DB00466 Picrotoxin
DB00502 Haloperidol
DB00514 Dextromethorphan
DB00529 Foscarnet
DB00563 Methotrexate
DB00577 Valaciclovir
DB00599 Thiopental
DB00627 Niacin
DB00659 Acamprosate
DB00721 Procaine
DB00731 Nateglinide
DB00740 Riluzole
DB00753 Isoflurane
DB00756 Hexachlorophene
DB00780 Phenelzine
DB00794 Primidone
DB00795 Sulfasalazine
DB00849 Methylphenobarbital
DB00898 Ethanol
DB00915 Amantadine
DB00936 Salicyclic acid
DB00949 Felbamate
DB00996 Gabapentin
DB01022 Phytonadione
DB01028 Methoxyflurane
DB01032 Probenecid
DB01043 Memantine
DB01080 Vigabatrin
DB01098 Rosuvastatin
DB01119 Diazoxide
DB01125 Anisindione
DB01159 Halothane
DB01161 Chloroprocaine
DB01173 Orphenadrine
DB01174 Phenobarbital
DB01189 Desflurane
DB01212 Ceftriaxone
DB01221 Ketamine
DB01235 Levodopa
DB01236 Sevoflurane
DB01275 Hydralazine
DB01287 Dihydroergotoxine
DB01346 Quinidine barbiturate
DB01351 Amobarbital
DB01352 Aprobarbital
DB01353 Butethal
DB01354 Heptabarbital
DB01355 Hexobarbital
DB01356 Lithium
DB01440 Gamma Hydroxybutyric Acid
DB01483 Barbital
DB01496 Barbituric acid derivative
DB01520 Tenocyclidine
DB01549 Rolicyclidine
DB01583 Liotrix
DB01610 Valganciclovir
DB01664 (S)-Des-Me-Ampa
DB01699 (4e)-4-Aminohex-4-Enoic Acid
DB01742 (3r)-1-Acetyl-3-Methylpiperidine
DB01746 D-Leucine
DB01762 Acetoacetic Acid
DB01786 D-Alanine
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01931 Dcka, 5,7-Dichlorokynurenic Acid
DB02057 AMPA
DB02078 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
DB02142 Pyridoxamine-5'-Phosphate
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02347 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid
DB02419 Ethyl Oxo(Piperidin-1-Yl)Acetate
DB02510 '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine
DB02556 D-Phenylalanine
DB02635 N-[O-Phosphono-Pyridoxyl]-Isoleucine
DB02684 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine
DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB02818 Iodo-Willardiine
DB02852 Domoic Acid
DB02952 Alpha-Aminoisobutyric Acid
DB02966 Fluoro-Willardiine
DB02999 Quisqualate
DB03066 D-Lactic Acid
DB03107 Beta-Alanine
DB03166 Acetic acid
DB03225 D-Tryptophan
DB03240 (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid
DB03256 5-Formyl-5,6,7,8-Tetrahydrofolate
DB03319 (S)-ATPA
DB03376 '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
DB03393 (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
DB03425 2s,4r-4-Methylglutamate
DB03431 Adenosine-5'-Diphosphate
DB03575 Phencyclidine
DB03759 Dnqx
DB03793 Benzoic Acid
DB03839 D-Tyrosine
DB03929 D-Serine
DB04000 Bromo-Willardiine
DB04074 Alpha-ketoisovalerate
DB04129 Willardiine
DB04137 Guanosine-5'-Triphosphate
DB04152 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid
DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid
DB04216 Quercetin
DB04235 4-Amino Hexanoic Acid
DB04256 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
DB04299 Maleic Acid
DB04319 6-Deoxyglucose
DB04348 Taurocholic Acid
DB04398 Lactic Acid
DB04447 1,4-Dithiothreitol
DB04552 Niflumic Acid
DB04599 Aniracetam
DB04620 Cycloleucine
DB04798 THIO-ATPA
DB04896 Milnacipran
DB06262 Droxidopa
DB06813 Pralatrexate
DB06928 (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID
DB07455 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide
DB07544 N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
DB07598 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE
DB07754 N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid
DB08168 7-AMINO-4-METHYL-CHROMEN-2-ONE
DB08303 (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
DB08304 (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
DB08305 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
DB08794 Ethyl biscoumacetate
DB08834 Tauroursodeoxycholic acid
DB08838 Agmatine
DB08883 Perampanel
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