DT-Web

DB00170 - Menadione


Identification
Name Menadione
Accession Number DB00170 (NUTR00062)
Type small molecule
Description A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 172.18
Groups approved
Monoisotopic Weight 172.0524295
Pharmacology
Indication The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
Mechanism of action Menadione (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of glutamic acid residues of certain proteins in the body. These proteins include the vitamin K-dependent coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor), X (Stuart factor), protein C, protein S, protein Zv and a growth-arrest-specific factor (Gas6). In contrast to the other vitamin K-dependent proteins in the blood coagulation cascade, protein C and protein S serve anticoagulant roles. The two vitamin K-dependent proteins found in bone are osteocalcin, also known as bone G1a (gamma-carboxyglutamate) protein or BGP, and the matrix G1a protein or MGP. Gamma-carboxylation is catalyzed by the vitamin K-dependent gamma-carboxylases. The reduced form of vitamin K, vitamin K hydroquinone, is the actual cofactor for the gamma-carboxylases. Proteins containing gamma-carboxyglutamate are called G1a proteins.
Absorption Variable and ranges from 10% to 80%
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Menadione (vitamin K3), which is not used as a nutritional supplemental form of vitamin K for humans, has been reported to cause adverse reactions, including hemolytic anemia. Large doses have also been reported to cause brain damage.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Vitamin K-dependent gamma-carboxylase
Name Vitamin K-dependent gamma-carboxylase
Gene Name GGCX
Pharmacological action yes
Actions cofactor
References
  • Wang Z, Wang M, Finn F, Carr BI: The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology. 1995 Sep;22(3):876-82. - Pubmed
  • Stafford DW: The vitamin K cycle. J Thromb Haemost. 2005 Aug;3(8):1873-8. - Pubmed
  • Presnell SR, Stafford DW: The vitamin K-dependent carboxylase. Thromb Haemost. 2002 Jun;87(6):937-46. - Pubmed
DTHybrid score 1.0176
Vitamin K epoxide reductase complex subunit 1
Name Vitamin K epoxide reductase complex subunit 1
Gene Name VKORC1
Pharmacological action yes
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oldenburg J, Bevans CG, Muller CR, Watzka M: Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):347-53. - Pubmed
  • Stafford DW: The vitamin K cycle. J Thromb Haemost. 2005 Aug;3(8):1873-8. - Pubmed
DTHybrid score 0.7118
Vitamin K epoxide reductase complex subunit 1-like protein 1
Name Vitamin K epoxide reductase complex subunit 1-like protein 1
Gene Name VKORC1L1
Pharmacological action yes
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oldenburg J, Bevans CG, Muller CR, Watzka M: Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):347-53. - Pubmed
  • Stafford DW: The vitamin K cycle. J Thromb Haemost. 2005 Aug;3(8):1873-8. - Pubmed
DTHybrid score 0.4006
Prothrombin
Name Prothrombin
Gene Name F2
Pharmacological action unknown
Actions activator
References
  • Lee SK, Lee JY, Lee MY, Chung SM, Chung JH: Advantages of calcium green-1 over other fluorescent dyes in measuring cytosolic calcium in platelets. Anal Biochem. 1999 Sep 10;273(2):186-91. - Pubmed
  • Casper HH, Alstad AD, Tacke DB, Johnson LJ, Lloyd WE: Evaluation of vitamin K3 feed additive for prevention of sweet clover disease. J Vet Diagn Invest. 1989 Apr;1(2):116-9. - Pubmed
  • McCarthy DJ, Lindamood C 3rd, Gundberg CM, Hill DL: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Toxicol Appl Pharmacol. 1989 Feb;97(2):300-10. - Pubmed
  • Szejtli J, Bolla-Pusztai E, Tardy-Lengyel M, Szabo P, Ferenczy T: Preparation, properties and biological activity of beta-cyclodextrin inclusion complex of menadione. Pharmazie. 1983 Mar;38(3):189-93. - Pubmed
  • Wang Z, Wang M, Finn F, Carr BI: The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology. 1995 Sep;22(3):876-82. - Pubmed
DTHybrid score 1.9643
Coagulation factor VII
Name Coagulation factor VII
Gene Name F7
Pharmacological action unknown
Actions activator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4693
Coagulation factor IX
Name Coagulation factor IX
Gene Name F9
Pharmacological action unknown
Actions activator
References
  • Berkessel A, Guixa M, Schmidt F, Neudorfl JM, Lex J: Highly enantioselective epoxidation of 2-methylnaphthoquinone (vitamin K3) mediated by new cinchona alkaloid phase-transfer catalysts. Chemistry. 2007;13(16):4483-98. - Pubmed
DTHybrid score 0.4936
Coagulation factor X
Name Coagulation factor X
Gene Name F10
Pharmacological action unknown
Actions activator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8013
Vitamin K-dependent protein C
Name Vitamin K-dependent protein C
Gene Name PROC
Pharmacological action unknown
Actions activator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Milgrom E, Diab H, Middleton F, Kane PM: Loss of vacuolar proton-translocating ATPase activity in yeast results in chronic oxidative stress. J Biol Chem. 2007 Mar 9;282(10):7125-36. Epub 2007 Jan 10. - Pubmed
DTHybrid score 0.9783
Vitamin K-dependent protein S
Name Vitamin K-dependent protein S
Gene Name PROS1
Pharmacological action unknown
Actions activator
References
  • Chai YC, Hendrich S, Thomas JA: Protein S-thiolation in hepatocytes stimulated by t-butyl hydroperoxide, menadione, and neutrophils. Arch Biochem Biophys. 1994 Apr;310(1):264-72. - Pubmed
  • Mallis RJ, Hamann MJ, Zhao W, Zhang T, Hendrich S, Thomas JA: Irreversible thiol oxidation in carbonic anhydrase III: protection by S-glutathiolation and detection in aging rats. Biol Chem. 2002 Mar-Apr;383(3-4):649-62. - Pubmed
DTHybrid score 0.943
Vitamin K-dependent protein Z
Name Vitamin K-dependent protein Z
Gene Name PROZ
Pharmacological action unknown
Actions activator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4005
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name Ribosyldihydronicotinamide dehydrogenase [quinone]
Gene Name NQO2
Pharmacological action unknown
Actions Not Available
References
  • Long DJ 2nd, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK: Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002 Nov 29;277(48):46131-9. Epub 2002 Sep 25. - Pubmed
  • Kwiek JJ, Haystead TA, Rudolph J: Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. Biochemistry. 2004 Apr 20;43(15):4538-47. - Pubmed
  • Foster CE, Bianchet MA, Talalay P, Zhao Q, Amzel LM: Crystal structure of human quinone reductase type 2, a metalloflavoprotein. Biochemistry. 1999 Aug 3;38(31):9881-6. - Pubmed
  • Celli CM, Tran N, Knox R, Jaiswal AK: NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Biochem Pharmacol. 2006 Jul 28;72(3):366-76. Epub 2006 May 4. - Pubmed
  • Boutin JA, Chatelain-Egger F, Vella F, Delagrange P, Ferry G: Quinone reductase 2 substrate specificity and inhibition pharmacology. Chem Biol Interact. 2005 Feb 10;151(3):213-28. - Pubmed
DTHybrid score 0.8914
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Pharmacological action unknown
Actions Not Available
References
  • Munday R, Smith BL, Munday CM: Effect of butylated hydroxyanisole on the toxicity of 2-hydroxy-1,4-naphthoquinone to rats. Chem Biol Interact. 1999 Feb 12;117(3):241-56. - Pubmed
  • Chiou TJ, Wang YT, Tzeng WF: DT-diaphorase protects against menadione-induced oxidative stress. Toxicology. 1999 Nov 29;139(1-2):103-10. - Pubmed
  • Munday R, Smith BL, Munday CM: Effect of inducers of DT-diaphorase on the toxicity of 2-methyl- and 2-hydroxy-1,4-naphthoquinone to rats. Chem Biol Interact. 1999 Dec 15;123(3):219-37. - Pubmed
  • Ip SP, Yiu HY, Ko KM: Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity. Mol Cell Biochem. 2000 May;208(1-2):151-5. - Pubmed
  • Kishi T, Takahashi T, Mizobuchi S, Mori K, Okamoto T: Effect of dicumarol, a Nad(P)h: quinone acceptor oxidoreductase 1 (DT-diaphorase) inhibitor on ubiquinone redox cycling in cultured rat hepatocytes. Free Radic Res. 2002 Apr;36(4):413-9. - Pubmed
DTHybrid score 0.9596
Osteocalcin
Name Osteocalcin
Gene Name BGLAP
Pharmacological action unknown
Actions agonist
References
  • Price PA: Role of vitamin-K-dependent proteins in bone metabolism. Annu Rev Nutr. 1988;8:565-83. - Pubmed
DTHybrid score 0.7535

Enzymes


Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions substrate
References
  • Yee SB, Pritsos CA: Comparison of oxygen radical generation from the reductive activation of doxorubicin, streptonigrin, and menadione by xanthine oxidase and xanthine dehydrogenase. Arch Biochem Biophys. 1997 Nov 15;347(2):235-41. - Pubmed
DTHybrid score 0.6225
Aldehyde oxidase
Name Aldehyde oxidase
Gene Name AOX1
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4414
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3881
Methylenetetrahydrofolate reductase
Name Methylenetetrahydrofolate reductase
Gene Name MTHFR
Actions substrate
References
  • Vanoni MA, Ballou DP, Matthews RG: Methylenetetrahydrofolate reductase. Steady state and rapid reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme. J Biol Chem. 1983 Oct 10;258(19):11510-4. - Pubmed
  • Clark JE, Ljungdahl LG: Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. J Biol Chem. 1984 Sep 10;259(17):10845-9. - Pubmed
DTHybrid score 0.3356
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3988
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5244
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4176

Predictions


Id Partner name Gene Name Score
5461 Coagulation factor IX F9 0.4936
2139 Tissue factor F3 0.3373
4512 Cytochrome P450 3A4 CYP3A4 0.3175
4757 Cytochrome P450 2C9 CYP2C9 0.2447
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.1953
4119 Cytochrome P450 2D6 CYP2D6 0.1784
6016 Cytochrome P450 2C19 CYP2C19 0.1722
19 Coagulation factor VIII F8 0.1705
4924 Cytochrome P450 2C8 CYP2C8 0.1448
3842 Multiple coagulation factor deficiency protein 2 MCFD2 0.14
3840 Asialoglycoprotein receptor 2 ASGR2 0.1399
3841 ERGIC-53 protein LMAN1 0.1398
1847 78 kDa glucose-regulated protein HSPA5 0.1398
1635 von Willebrand factor VWF 0.1397
1588 Multidrug resistance protein 1 ABCB1 0.1336
1516 Calnexin CANX 0.1217
6030 Cytochrome P450 2B6 CYP2B6 0.1211
3830 Calreticulin CALR 0.1162
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.1068
3176 Trypsin-1 PRSS1 0.1044
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.104
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.104
4118 Cytochrome P450 3A5 CYP3A5 0.1021
1898 Cytochrome P450 1B1 CYP1B1 0.0992
1334 Tissue factor pathway inhibitor TFPI 0.0991
1959 Platelet factor 4 PF4 0.0924
3865 Serpin B6 SERPINB6 0.0923
1986 Ceruloplasmin CP 0.0923
2159 Quinone oxidoreductase CRYZ 0.0923
1757 Myeloperoxidase MPO 0.0817
587 Serum albumin ALB 0.0807
3833 Plasma serine protease inhibitor SERPINA5 0.0804
3851 Serine protease hepsin HPN 0.0795
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.078
5142 Protein-tyrosine-phosphatase PPI 0.0747
46 Coagulation factor V F5 0.0722
2021 Thrombomodulin THBD 0.0713
2072 Endothelial protein C receptor PROCR 0.0712
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0708
6315 V-type proton ATPase subunit B, brain isoform ATP6V1B2 0.0665
6107 Cytochrome P450 3A7 CYP3A7 0.0662
904 Glutathione S-transferase P GSTP1 0.0647
267 Plasminogen activator inhibitor 1 SERPINE1 0.0617
1654 Interleukin-1 beta IL1B 0.061
1547 Coagulation factor XI F11 0.0598
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0568
3811 Cytochrome P450 19A1 CYP19A1 0.0559
6142 Solute carrier family 22 member 8 SLC22A8 0.0553
566 Serotransferrin TF 0.0535
309 Antithrombin-III SERPINC1 0.0533
20 Prostaglandin G/H synthase 1 PTGS1 0.0512
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0497
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0485
6143 Solute carrier family 22 member 7 SLC22A7 0.0478
1729 Solute carrier family 22 member 6 SLC22A6 0.0477
290 Prostaglandin G/H synthase 2 PTGS2 0.0455
6106 Cytochrome P450 2C18 CYP2C18 0.0453
4407 FMN-dependent NADH-azoreductase azoR 0.045
5169 FMN-dependent NADH-azoreductase azoR 0.045
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0449
723 Cytosolic phospholipase A2 PLA2G4A 0.042
3941 Amine oxidase [flavin-containing] A MAOA 0.0399
2164 Multidrug resistance-associated protein 4 ABCC4 0.0399
1074 Urokinase-type plasminogen activator PLAU 0.0362
318 Alpha-2A adrenergic receptor ADRA2A 0.0347
2353 Apolipoprotein(a) LPA 0.0343
5698 Riboflavin synthase alpha chain ribE 0.0336
896 Glutathione S-transferase Mu 1 GSTM1 0.0329
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0328
136 Estrogen receptor ESR1 0.0327
468 Cytochrome P450 4A11 CYP4A11 0.0325
6136 Multidrug resistance-associated protein 5 ABCC5 0.0324
24 Thymidylate synthase TMP1 0.0318
359 Thymidylate synthase TYMS 0.0318
2626 Thymidylate synthase thyA 0.0318
2729 Thymidylate synthase thyA 0.0318
5352 Thymidylate synthase THYA 0.0318
408 Riboflavin kinase RFK 0.031
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0308
809 Methionine synthase MTR 0.0307
2935 Methionine synthase metH 0.0307
234 Plasminogen PLG 0.0306
6144 Solute carrier family 22 member 2 SLC22A2 0.0304
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0304
6146 High affinity copper uptake protein 1 SLC31A1 0.0283
1405 Thiopurine S-methyltransferase TPMT 0.028
862 Multidrug resistance-associated protein 1 ABCC1 0.0278
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0277
4228 Keratin, type II cytoskeletal 7 KRT7 0.0276
293 Gamma-glutamyl hydrolase GGH 0.0276
6163 Copper-transporting ATPase 2 ATP7B 0.0275
6145 Solute carrier family 22 member 1 SLC22A1 0.0275
6165 Copper-transporting ATPase 1 ATP7A 0.0275
1792 Tissue-type plasminogen activator PLAT 0.0268
244 Angiotensin-converting enzyme ACE 0.0267
629 Alpha-2B adrenergic receptor ADRA2B 0.0264
492 Histamine H1 receptor HRH1 0.0264
4604 Liver carboxylesterase 1 CES1 0.0263
378 Alpha-2C adrenergic receptor ADRA2C 0.0262
776 Bile salt export pump ABCB11 0.0261
908 Glutathione S-transferase theta-1 GSTT1 0.0261
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.026
36 Insulin receptor INSR 0.0258
465 Calmodulin CALM1 0.0252
6014 Cytochrome P450 2A13 CYP2A13 0.025
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0248
338 DNA polymerase UL30 0.0246
379 DNA polymerase UL54 0.0246
697 DNA polymerase ORF28 0.0246
2482 DNA polymerase 43 0.0246
4104 DNA polymerase BALF5 0.0246
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0243
840 Methionine synthase reductase, mitochondrial MTRR 0.0238
3932 Glutathione S-transferase A2 GSTA2 0.0237
556 Alpha-1A adrenergic receptor ADRA1A 0.0236
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0235
654 Flavin reductase BLVRB 0.0234
1650 Heme carrier protein 1 SLC46A1 0.0234
817 DNA topoisomerase 2-alpha TOP2A 0.0232
831 D(2) dopamine receptor DRD2 0.0224
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0224
118 Organic cation/carnitine transporter 2 SLC22A5 0.0222
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.022
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0212
766 Beta-2 adrenergic receptor ADRB2 0.0209
833 Organic cation/carnitine transporter 1 SLC22A4 0.0209
6148 Multidrug resistance-associated protein 7 ABCC10 0.0204
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0203
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0202
6147 Solute carrier family 22 member 3 SLC22A3 0.0198
718 Folate receptor gamma FOLR3 0.0197
804 Mitochondrial folate transporter/carrier SLC25A32 0.0197
299 Folate receptor beta FOLR2 0.0197
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0194
3939 Amine oxidase [flavin-containing] B MAOB 0.0193
811 Translocator protein TSPO 0.0192
502 5-hydroxytryptamine 2A receptor HTR2A 0.0192
3823 Cytokine receptor common gamma chain IL2RG 0.019
327 Glutathione reductase gor 0.019
5110 Glutathione reductase GR2 0.019
824 Sodium-dependent serotonin transporter SLC6A4 0.0187
590 5-hydroxytryptamine 2C receptor HTR2C 0.018
341 5-hydroxytryptamine 3 receptor HTR3A 0.0179
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0178
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0177
6171 Solute carrier family 28 member 3 SLC28A3 0.0176
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0173
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0172
869 Estrogen receptor beta ESR2 0.0172
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0171
193 Beta-1 adrenergic receptor ADRB1 0.0171
6182 Cytochrome P450 2J2 CYP2J2 0.017
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0168
3119 Fimbrial protein pilE1 0.0168
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0168
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0167
3923 Cholinesterase BCHE 0.0167
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0166
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
724 Interleukin-2 receptor alpha chain IL2RA 0.0165
717 Interleukin-2 receptor subunit beta IL2RB 0.0165
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0164
6137 Multidrug resistance-associated protein 6 ABCC6 0.0164
1719 Heparanase HPSE 0.0164
477 DNA topoisomerase 4 subunit A parC 0.0163
886 DNA topoisomerase 4 subunit A parC 0.0163
6226 DNA topoisomerase 4 subunit A parC 0.0163
777 Tumor necrosis factor TNF 0.0162
613 Atrial natriuretic peptide receptor A NPR1 0.0161
404 DNA gyrase subunit A gyrA 0.0161
6224 DNA gyrase subunit A gyrA 0.0161
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.016
373 Transthyretin TTR 0.016
16 Adenosine A1 receptor ADORA1 0.016
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0159
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0158
2236 Casein kinase II subunit alpha CSNK2A1 0.0157
2058 P-selectin SELP 0.0156
507 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB 0.0152
3916 Methylmalonic aciduria and homocystinuria type C protein MMACHC 0.0152
354 Methylmalonic aciduria type A protein, mitochondrial MMAA 0.0152
398 Transcobalamin-2 TCN2 0.0152
265 Transcobalamin-1 TCN1 0.0152
376 Amnionless protein AMN 0.0152
854 Methylmalonyl-CoA mutase, mitochondrial MUT 0.0152
1224 Cubilin CUBN 0.0152
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0151
23 D(1A) dopamine receptor DRD1 0.0151
260 Cytochrome P450 51 ERG11 0.015
761 Cytochrome P450 51 ERG11 0.015
3163 Cytochrome P450 51 cyp51 0.015
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
885 5-hydroxytryptamine 1B receptor HTR1B 0.0147
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0145
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0144
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0143
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0141
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0139
571 Melatonin receptor type 1A MTNR1A 0.0139
3426 Glutamine synthetase glnA 0.0139
3987 Glutamine synthetase GLUL 0.0139
362 Melatonin receptor type 1B MTNR1B 0.0139
4226 Uridine phosphorylase 2 UPP2 0.0136
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0134
482 Glycine receptor subunit alpha-1 GLRA1 0.0132
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0131
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0131
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.013
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.013
6102 Arylamine N-acetyltransferase 2 NAT2 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
705 Glutamate receptor 1 GRIA1 0.0128
4120 NADPH--cytochrome P450 reductase POR 0.0128
251 Alcohol dehydrogenase 1A ADH1A 0.0127
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0126
320 5-hydroxytryptamine 1A receptor HTR1A 0.0126
1656 CYP2B protein CYP2B 0.0125
1178 Adenosine A2a receptor ADORA2A 0.0125
317 Methionine-R-sulfoxide reductase SEPX1 0.0123
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0122
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0122
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0122
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0122
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0122
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0122
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0122
6168 Solute carrier family 22 member 16 SLC22A16 0.0122
6564 Prephenate dehydrogenase tyrA 0.0122
6240 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
444 Alcohol dehydrogenase 1B ADH1B 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.012
5818 Folate receptor alpha FOLR1 0.012
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0119
4225 Uridine phosphorylase 1 UPP1 0.0118
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0118
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0118
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0117
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0117
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0117
413 Amidophosphoribosyltransferase PPAT 0.0116
2515 Amidophosphoribosyltransferase purF 0.0116
3714 Amidophosphoribosyltransferase purF 0.0116
48 Pyridoxal kinase PDXK 0.0116
725 5-hydroxytryptamine 1D receptor HTR1D 0.0115
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0114
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0114
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0113
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0112
537 ATP synthase delta chain, mitochondrial ATP5D 0.0111
6034 Hydroxyindole O-methyltransferase ASMT 0.0111
6035 Nuclear receptor ROR-beta RORB 0.0111
6036 Eosinophil peroxidase EPX 0.0111
6031 Cytochrome P450 3A43 CYP3A43 0.0111
914 Formimidoyltransferase-cyclodeaminase FTCD 0.011
871 Glucocorticoid receptor NR3C1 0.011
632 Alpha-1B adrenergic receptor ADRA1B 0.0109
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0109
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0109
59 AMT protein AMT 0.0109
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0109
713 Sodium-dependent dopamine transporter SLC6A3 0.0108
2230 Catalase CAT 0.0108
3249 Catalase katA 0.0108
3625 Catalase katA 0.0108
4539 Catalase katA 0.0108
4941 Catalase katB 0.0108
1024 Solute carrier family 22 member 11 SLC22A11 0.0106
13 Aminomethyltransferase, mitochondrial AMT 0.0106
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0106
6859 Protein S100-A4 S100A4 0.0105
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0105
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0104
191 Peptide methionine sulfoxide reductase MSRA 0.0102
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.01
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.01
2331 HTH-type transcriptional regulator qacR qacR 0.01
6461 HTH-type transcriptional regulator qacR qacR 0.01
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.01
4031 Glutathione S-transferase A1 GSTA1 0.01
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
123 Diamine acetyltransferase 1 SAT1 0.01
6220 Aryl hydrocarbon receptor AHR 0.0099
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0099
517 Alcohol dehydrogenase 1C ADH1C 0.0098
1010 Cytochrome P450 51A1 CYP51A1 0.0098
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0098
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0097
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0096
638 D(3) dopamine receptor DRD3 0.0096
365 Dihydrofolate reductase DHFR 0.0096
2381 Dihydrofolate reductase DFR1 0.0096
2833 Dihydrofolate reductase Not Available 0.0096
2931 Dihydrofolate reductase folA 0.0096
3544 Dihydrofolate reductase folA 0.0096
3682 Dihydrofolate reductase folA 0.0096
6642 Dihydrofolate reductase folA 0.0096
6756 Dihydrofolate reductase dfrA 0.0096
765 Indoleamine 2,3-dioxygenase IDO1 0.0095
6828 TetR family transcriptional repressor LfrR lfrR 0.0095
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0095
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0094
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0094
275 Arachidonate 5-lipoxygenase ALOX5 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0093
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0093
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0092
3639 Thymidine phosphorylase deoA 0.0092
3936 Thymidine phosphorylase TYMP 0.0092
1517 Beta-3 adrenergic receptor ADRB3 0.0091
714 Glutathione reductase, mitochondrial GSR 0.0091
3384 Macrophage migration inhibitory factor MIF 0.009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0089
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0089
738 Monocarboxylate transporter 1 SLC16A1 0.0089
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0089
6766 O-GlcNAcase BT_4395 BT_4395 0.0089
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0089
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0088
1374 Natriuretic peptides B NPPB 0.0088
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0088
1827 Gap junction alpha-1 protein GJA1 0.0088
1908 Vascular cell adhesion protein 1 VCAM1 0.0088
789 Alpha-1D adrenergic receptor ADRA1D 0.0087
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0087
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0086
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0086
2449 Tubulin alpha-3 chain TUBA1A 0.0086
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0085
33 Cystine/glutamate transporter SLC7A11 0.0085
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0083
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0082
997 Protein kinase C beta type PRKCB 0.0082
3884 SHMT2 protein SHMT2 0.0081
3901 SHMT2 protein SHMT2 0.0081
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0081
3879 Serine hydroxymethyltransferase 2 Not Available 0.0081
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0081
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.008
921 Glutamate receptor 2 GRIA2 0.008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0079
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0079
449 Ornithine decarboxylase ODC1 0.0078
6151 Monocarboxylate transporter 10 SLC16A10 0.0078
4122 Histone deacetylase 2 HDAC2 0.0078
76 Nitric-oxide synthase, brain NOS1 0.0078
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0077
7 Nitric oxide synthase, inducible NOS2 0.0075
94 5-hydroxytryptamine 4 receptor HTR4 0.0075
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0075
1192 Sulfotransferase 1A1 SULT1A1 0.0075
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0074
1970 Protein kinase C alpha type PRKCA 0.0074
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0073
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0073
380 Cytochrome P450 17A1 CYP17A1 0.0072
4192 DNA topoisomerase 2-beta TOP2B 0.0071
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0071
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0071
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.007
4238 50S ribosomal protein L4 rplD 0.007
5578 50S ribosomal protein L4 rplD 0.007
6173 50S ribosomal protein L4 rplD 0.007
6219 50S ribosomal protein L4 rplD 0.007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.007
295 Carbonic anhydrase 1 CA1 0.007
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0069
810 Heme oxygenase 1 HMOX1 0.0068
3391 Heme oxygenase 1 pbsA1 0.0068
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0068
183 Vascular endothelial growth factor A VEGFA 0.0068
820 Glycine receptor subunit alpha-2 GLRA2 0.0067
2795 Methionine aminopeptidase 2 METAP2 0.0066
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0065
432 D(4) dopamine receptor DRD4 0.0065
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0065
4237 50S ribosomal protein L22 rplV 0.0065
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0064
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0064
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0064
6126 Carbonic anhydrase 7 CA7 0.0064
891 Dihydropteroate synthase folP 0.0064
5359 Dihydropteroate synthase folP 0.0064
7175 Dihydropteroate synthase sulI 0.0064
814 Ryanodine receptor 1 RYR1 0.0064
1820 Beta-nerve growth factor NGF 0.0064
4076 Diacylglycerol kinase alpha DGKA 0.0063
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0063
375 SEC14-like protein 3 SEC14L3 0.0063
86 SEC14-like protein 4 SEC14L4 0.0063
708 Alpha-tocopherol transfer protein TTPA 0.0063
844 Epidermal growth factor receptor EGFR 0.0063
518 Peroxidase/catalase T katG 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0062
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0062
283 SEC14-like protein 2 SEC14L2 0.0062
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0062
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0062
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.006
6131 Carbonic anhydrase 14 CA14 0.006
569 Retinal dehydrogenase 2 ALDH1A2 0.006
563 Thyroid peroxidase TPO 0.0059
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0059
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0058
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0058
106 Cannabinoid receptor 2 CNR2 0.0058
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0058
291 Nitric-oxide synthase, endothelial NOS3 0.0057
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0057
611 Retinal dehydrogenase 1 ALDH1A1 0.0056
716 5-hydroxytryptamine 7 receptor HTR7 0.0056
5122 Mersacidin decarboxylase mrsD 0.0056
5095 Putidaredoxin reductase camA 0.0056
526 Thioredoxin reductase trxB 0.0056
3767 Thioredoxin reductase trxB 0.0056
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0056
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0056
5078 Amine oxidase, flavin-containing PSPTO1126 0.0056
3763 5,10-methylenetetrahydrofolate reductase metF 0.0056
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0056
5094 5,10-methylenetetrahydrofolate reductase metF 0.0056
5115 FkbI fkbI 0.0056
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0056
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0056
3133 UDP-galactopyranose mutase glf 0.0056
5099 UDP-galactopyranose mutase glf 0.0056
5083 Cryptochrome DASH cry 0.0056
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0056
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0056
5109 Outer membrane protein p64k or PM-6 m-6 0.0056
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0056
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0056
5081 L-aspartate oxidase nadB 0.0056
1410 Oxidoreductase HSD17B6 0.0056
4725 Oxidoreductase Not Available 0.0056
5124 Oxidoreductase Not Available 0.0056
5111 Phenylacetone monooxygenase pamO 0.0056
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0056
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0056
84 Nuclear receptor 0B1 NR0B1 0.0056
6122 Carbonic anhydrase 3 CA3 0.0056
511 5-hydroxytryptamine 1F receptor HTR1F 0.0055
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0055
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0055
436 5-hydroxytryptamine 2B receptor HTR2B 0.0055
4486 Phenol 2-hydroxylase component B pheA2 0.0054
4477 Dihydrolipoyl dehydrogenase lpdV 0.0054
5077 Dihydrolipoyl dehydrogenase Not Available 0.0054
5117 Dihydrolipoyl dehydrogenase lpd 0.0054
4439 Ferredoxin reductase bphA4 0.0054
68 Cannabinoid receptor 1 CNR1 0.0054
551 Carnitine O-acetyltransferase CRAT 0.0054
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0054
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0054
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0054
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0053
905 Glutathione transferase omega-1 GSTO1 0.0053
899 Glutathione S-transferase Mu 3 GSTM3 0.0053
122 P2Y purinoceptor 12 P2RY12 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
592 Carbonic anhydrase 4 CA4 0.0052
1714 Mitogen-activated protein kinase 3 MAPK3 0.0052
2298 Cytochrome P450-cam camC 0.0052
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0052
3810 Catechol O-methyltransferase COMT 0.0051
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0051
3007 Carbonic anhydrase 12 CA12 0.005
4205 Carbonic anhydrase 9 CA9 0.005
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0049
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0049
5073 Ferredoxin--NADP reductase petH 0.0049
5076 Ferredoxin--NADP reductase fpr 0.0049
5119 Ferredoxin--NADP reductase petH 0.0049
5121 Ferredoxin--NADP reductase fpr 0.0049
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0049
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0049
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0049
2526 NADPH-ferredoxin reductase fprA fprA 0.0049
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0049
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0049
3594 Deoxyribodipyrimidine photo-lyase phr 0.0049
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0049
5080 Deoxyribodipyrimidine photo-lyase phr 0.0049
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0049
5072 N,N-dimethylglycine oxidase dmg 0.0049
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0049
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0049
2470 Pyruvate oxidase pox5 0.0048
2268 Cholesterol oxidase choB 0.0048
2822 Cholesterol oxidase choA 0.0048
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0048
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0048
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0048
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0048
3102 Flavohemoprotein hmp 0.0048
4969 Flavohemoprotein hmp 0.0048
4440 NADH peroxidase npr 0.0048
823 Fibroblast growth factor receptor 2 FGFR2 0.0047
3937 Fatty-acid amide hydrolase FAAH 0.0047
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
4311 tRNA TRDMT1 0.0047
4325 tRNA trmD 0.0047
4328 tRNA trmD 0.0047
6141 Sodium/bile acid cotransporter SLC10A1 0.0047
4165 P2Y purinoceptor 2 P2RY2 0.0047
473 L-lactate dehydrogenase A chain LDHA 0.0046
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0045
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0045
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0045
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0044
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0044
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0044
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0044
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0044
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0044
2893 Glycine oxidase thiO 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
6128 Carbonic anhydrase-related protein 10 CA10 0.0044
6133 Sodium channel subunit beta-2 SCN2B 0.0044
6134 Sodium channel subunit beta-3 SCN3B 0.0044
6132 Sodium channel subunit beta-1 SCN1B 0.0044
6135 Sodium channel subunit beta-4 SCN4B 0.0044
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0044
6129 Carbonic anhydrase-related protein 11 CA11 0.0044
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0044
6127 Carbonic anhydrase-related protein CA8 0.0044
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0044
735 Alanine aminotransferase 1 GPT 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
126 D-lactate dehydrogenase dld 0.0043
3545 D-lactate dehydrogenase Not Available 0.0043
4510 D-lactate dehydrogenase ldhA 0.0043
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0043
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0042
2567 Thymidylate synthase thyX thyX 0.0042
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0042
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0042
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0042
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0042
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0042
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0042
2823 Trypanothione reductase TPR 0.0042
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0042
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0042
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0042
4019 Excitatory amino acid transporter 4 SLC1A6 0.0042
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0042
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0042
4026 Aspartyl aminopeptidase DNPEP 0.0042
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0042
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0042
1912 Excitatory amino acid transporter 1 SLC1A3 0.0042
4016 Excitatory amino acid transporter 5 SLC1A7 0.0042
1047 Excitatory amino acid transporter 2 SLC1A2 0.0042
922 Glutamate receptor 4 GRIA4 0.0042
664 Glutamate decarboxylase 2 GAD2 0.0042
3890 Glutamate decarboxylase 2 GAD2 0.0042
926 Metabotropic glutamate receptor 7 GRM7 0.0042
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0042
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0042
927 Metabotropic glutamate receptor 8 GRM8 0.0042
925 Metabotropic glutamate receptor 4 GRM4 0.0042
4020 Glutamyl aminopeptidase ENPEP 0.0042
4018 Glutamate receptor delta-2 subunit GRID2 0.0042
4027 Glutamate receptor delta-1 subunit GRID1 0.0042
4017 5-oxoprolinase OPLAH 0.0042
2981 Phospholipase A2, membrane associated PLA2G2A 0.0041
3809 Estrogen-related receptor gamma ESRRG 0.0041
1256 5-hydroxytryptamine 6 receptor HTR6 0.0041
2769 P-hydroxybenzoate hydroxylase pobA 0.0041
2809 P-hydroxybenzoate hydroxylase pobA 0.0041
1275 Estrogen sulfotransferase SULT1E1 0.004
5934 Cytochrome P450 26A1 CYP26A1 0.004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.004
3957 Adenosine deaminase ADA 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0039
2380 Monomeric sarcosine oxidase soxA 0.0039
1050 Bile salt sulfotransferase SULT2A1 0.0039
357 Carbonic anhydrase 2 CA2 0.0038
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
976 Platelet glycoprotein IX GP9 0.0038
6130 Carbonic anhydrase 13 CA13 0.0038
822 Aldose reductase AKR1B1 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
2654 Complement control protein C3L 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0037
6645 D-amino-acid oxidase DAO 0.0037
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0037
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0037
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0037
917 Glutaminase kidney isoform, mitochondrial GLS 0.0036
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0036
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0036
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0036
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0036
5 Glutaminase liver isoform, mitochondrial GLS2 0.0036
665 Phosphoserine aminotransferase PSAT1 0.0036
4652 Phosphoserine aminotransferase serC 0.0036
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0036
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0036
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0036
5261 Phosphoribosylformylglycinamidine synthase purL 0.0036
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0036
420 Glutamate decarboxylase 1 GAD1 0.0036
3900 Glutamate decarboxylase 1 GAD1 0.0036
284 DNA-directed RNA polymerase beta chain rpoB 0.0036
5773 DNA-directed RNA polymerase beta chain rpoB 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
6043 Putative G-protein coupled receptor 44 GPR44 0.0036
6432 Transporter snf 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0035
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
430 Follicle-stimulating hormone receptor FSHR 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
153 Dopamine beta-hydroxylase DBH 0.0034
847 Mu-type opioid receptor OPRM1 0.0034
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0033
4116 Dihydropteroate synthetase Not Available 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
625 Glutamate carboxypeptidase 2 FOLH1 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
916 Metabotropic glutamate receptor 1 GRM1 0.0033
3877 Growth-inhibiting protein 18 GIG18 0.0033
1671 Excitatory amino acid transporter 3 SLC1A1 0.0033
627 11-cis retinol dehydrogenase RDH5 0.0033
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0033
923 Glutamate receptor 3 GRIA3 0.0032
5455 Arylsulfatase A ARSA 0.0032
232 Corticosteroid-binding globulin SERPINA6 0.0032
780 Retinoic acid receptor RXR-gamma RXRG 0.0032
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0032
228 Beta platelet-derived growth factor receptor PDGFRB 0.0032
146 Androgen receptor AR 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
268 Adenosine A2b receptor ADORA2B 0.0031
763 Tyrosine aminotransferase TAT 0.0031
5493 Tyrosine aminotransferase Not Available 0.0031
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0031
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0031
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0031
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0031
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0031
770 Retinoic acid-induced protein 3 GPRC5A 0.0031
719 Retinoic acid receptor responder protein 1 RARRES1 0.0031
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0031
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0031
1629 Transcription factor AP-1 JUN 0.0031
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
426 Aspartate aminotransferase, mitochondrial GOT2 0.0031
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0031
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.003
818 50S ribosomal protein L10 rplJ 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
731 HIV-1 protease HIV-1 protease 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
2112 Toll-like receptor 9 TLR9 0.0029
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0029
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0029
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0029
504 Mast/stem cell growth factor receptor KIT 0.0029
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0029
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0029
88 Retinoic acid receptor RXR-beta RXRB 0.0029
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0029
131 Synaptic vesicular amine transporter SLC18A2 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
162 Retinoic acid receptor gamma-1 RARG 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0028
816 Biliverdin reductase A BLVRA 0.0028
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0028
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0028
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0028
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0028
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0028
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0028
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0028
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0027
696 Kappa-type opioid receptor OPRK1 0.0027
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0027
3404 Exotoxin A eta 0.0027
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0027
469 Annexin A1 ANXA1 0.0026
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0026
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0026
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0026
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0026
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0026
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0026
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0026
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0026
467 Delta-type opioid receptor OPRD1 0.0026
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0026
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0026
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0026
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0026
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0026
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0026
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0026
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0026
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0026
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0026
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0026
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0026
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0026
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0026
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0026
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0026
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0026
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0026
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0026
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0026
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0026
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0026
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0026
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0026
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0026
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0025
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0025
107 C-4 methylsterol oxidase SC4MOL 0.0025
167 L-lactate dehydrogenase C chain LDHC 0.0025
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0025
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0025
206 3-keto-steroid reductase HSD17B7 0.0025
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0025
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0025
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0025
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0025
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0025
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0025
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0025
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0025
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0025
711 UDP-glucose 6-dehydrogenase UGDH 0.0025
3672 UDP-glucose 6-dehydrogenase hasB 0.0025
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0025
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0025
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0025
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0025
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0025
644 Heme oxygenase 2 HMOX2 0.0025
4982 Heme oxygenase 2 pbsA2 0.0025
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0025
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0025
729 GDP-L-fucose synthetase TSTA3 0.0025
3463 GDP-L-fucose synthetase fcl 0.0025
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0025
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0025
34 7-dehydrocholesterol reductase DHCR7 0.0025
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0025
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0025
3726 D-3-phosphoglycerate dehydrogenase serA 0.0025
4291 D-3-phosphoglycerate dehydrogenase serA 0.0025
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0025
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0025
756 Sex hormone-binding globulin SHBG 0.0025
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0025
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0025
643 Peroxisomal bifunctional enzyme EHHADH 0.0025
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0025
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0025
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0025
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0025
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
646 Malate dehydrogenase, cytoplasmic MDH1 0.0025
5880 Thrombopoietin receptor MPL 0.0025
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0025
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0025
328 Sorbitol dehydrogenase SORD 0.0025
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0025
597 Dihydropteridine reductase QDPR 0.0025
396 Alcohol dehydrogenase 4 ADH4 0.0025
124 Histamine H2 receptor HRH2 0.0025
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0024
666 NADP-dependent malic enzyme ME1 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0024
4102 Proteasome subunit beta type 5 PSMB5 0.0024
4101 Proteasome subunit beta type 1 PSMB1 0.0024
6070 Nischarin NISCH 0.0024
857 Malate dehydrogenase, mitochondrial MDH2 0.0024
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0023
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0023
77 L-lactate dehydrogenase B chain LDHB 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
12 Alcohol dehydrogenase class 3 ADH5 0.0023
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0023
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0023
1268 Neuropeptide S receptor NPSR1 0.0023
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0023
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0023
358 Cystathionine beta-synthase CBS 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0022
164 Histamine H4 receptor HRH4 0.0022
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0022
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0022
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
6026 Alcohol dehydrogenase 6 ADH6 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
737 Mineralocorticoid receptor NR3C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0021
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0021
626 Cysteine dioxygenase type 1 CDO1 0.0021
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0021
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
6073 Potassium channel subfamily K member 9 KCNK9 0.0021
6072 Potassium channel subfamily K member 3 KCNK3 0.0021
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
614 Progesterone receptor PGR 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
936 Ephrin type-A receptor 2 EPHA2 0.002
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
279 Tyrosinase TYR 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0018
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
1992 Vitamin D-binding protein GC 0.0018
1039 Histone deacetylase 9 HDAC9 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
1648 Elastin ELN 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
1830 5'-nucleotidase NT5E 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
1243 Cathepsin D CTSD 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0016
474 Acetylcholinesterase ACHE 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
427 Substance-P receptor TACR1 0.0016
2207 Rhodopsin RHO 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0016
2320 Thymidine kinase, cytosolic TK1 0.0015
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
29 Tubulin beta-1 chain TUBB1 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
2091 Endoplasmin HSP90B1 0.0014
1618 High affinity nerve growth factor receptor NTRK1 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
856 Vitamin D3 receptor VDR 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
6085 Fatty acid-binding protein, intestinal FABP2 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.001
345 Plasma retinol-binding protein RBP4 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
6459 Glycodelin PAEP 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
760 Fibroblast growth factor 1 FGF1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
↑