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Phosphatidylinositol 3-kinase regulatory subunit gamma


Partner ID 4146
Name Phosphatidylinositol 3-kinase regulatory subunit gamma
Synonyms 6623
Gene name PIK3R3
General function Involved in phosphoinositide 3-kinase regulator activity
Specific function Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1
Gene sequence + ...

ATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTCCAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAAAAATGCAGGGAGATTATACTTTGACTTTGCGGAAGGGAGGCAATAATAAGTTAATAAAGATCTATCACCGGGATGGTAAATATGGCTTTTCTGATCCTCTGACATTTAATTCCGTGGTGGAGCTCATTAACCACTATCACCATGAATCTCTTGCTCAGTACAATCCCAAACTTGATGTGAAGCTGATGTACCCAGTGTCCAGATACCAACAGGATCAGTTGGTAAAAGAAGATAATATTGATGCAGTAGGTAAAAAACTGCAAGAATACCACTCTCAGTATCAGGAGAAGAGTAAAGAGTATGATAGGCTGTATGAAGAATATACTAGAACATCCCAGGAAATACAGATGAAGAGGACTGCAATAGAAGCTTTTAATGAAACAATTAAAATATTTGAAGAGCAGTGTCACACACAAGAACAACATAGCAAAGAATATATTGAGCGATTTCGCAGAGAGGGGAATGAAAAGGAGATTGAACGAATTATGATGAATTATGATAAATTGAAATCACGTCTGGGTGAGATTCATGATAGCAAAATGCGTCTAGAGCAGGATTTGAAGAAACAAGCTTTGGACAACCGAGAAATAGATAAAAAAATGAATAGTATCAAACCTGACCTGATCCAGCTGCGAAAGATCCGAGATCAACACCTTGTATGGCTCAATCACAAAGGAGTGAGACAGAAACGCCTGAATGTCTGGCTGGGAATTAAGAATGAGGATGCTGATGAGAACTATTTTATCAATGAGGAAGATGAAAACCTGCCCCATTATGATGAGAAAACCTGGTTTGTTGAGGATATCAATCGAGTACAAGCAGAGGACTTGCTTTATGGGAAACCTGATGGTGCATTCTTAATTCGTGAGAGTAGCAAGAAAGGATGCTATGCTTGCTCTGTGGTGGCCGATGGGGAAGTGAAGCACTGTGTGATCTACAGCACTGCTCGGGGCTATGGCTTTGCAGAGCCCTACAACCTGTACAGCTCTCTGAAGGAGCTAGTGCTCCATTACCAGCAGACATCCTTGGTTCAGCACAACGACTCCCTCAACGTCAGGCTTGCCTACCCTGTTCATGCACAGATGCCCTCGCTTTGCAGATAA
Protein sequence + ...

MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
GO Classification
component
phosphoinositide 3-kinase complex
protein complex
function
lipid kinase activity
phosphoinositide 3-kinase activity
phosphatidylinositol 3-kinase activity
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
process
intracellular signaling cascade
cellular process
cell communication
signal transduction
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01064 Isoproterenol

Associated as Prediction

Id Name
DB00162 Vitamin A
DB00165 Pyridoxine
DB00169 Cholecalciferol
DB00170 Menadione
DB00176 Fluvoxamine
DB00184 Nicotine
DB00187 Esmolol
DB00188 Bortezomib
DB00195 Betaxolol
DB00197 Troglitazone
DB00201 Caffeine
DB00203 Sildenafil
DB00208 Ticlopidine
DB00221 Isoetharine
DB00264 Metoprolol
DB00277 Theophylline
DB00316 Acetaminophen
DB00317 Gefitinib
DB00325 Nitroprusside
DB00335 Atenolol
DB00338 Omeprazole
DB00356 Chlorzoxazone
DB00363 Clozapine
DB00368 Norepinephrine
DB00373 Timolol
DB00381 Amlodipine
DB00396 Progesterone
DB00397 Phenylpropanolamine
DB00428 Streptozocin
DB00448 Lansoprazole
DB00449 Dipivefrin
DB00457 Prazosin
DB00466 Picrotoxin
DB00468 Quinine
DB00470 Dronabinol
DB00489 Sotalol
DB00499 Flutamide
DB00502 Haloperidol
DB00518 Albendazole
DB00521 Carteolol
DB00526 Oxaliplatin
DB00530 Erlotinib
DB00539 Toremifene
DB00553 Methoxsalen
DB00568 Cinnarizine
DB00571 Propranolol
DB00575 Clonidine
DB00586 Diclofenac
DB00598 Labetalol
DB00605 Sulindac
DB00608 Chloroquine
DB00612 Bisoprolol
DB00613 Amodiaquine
DB00624 Testosterone
DB00633 Dexmedetomidine
DB00636 Clofibrate
DB00643 Mebendazole
DB00655 Estrone
DB00668 Epinephrine
DB00675 Tamoxifen
DB00682 Warfarin
DB00693 Fluorescein
DB00694 Daunorubicin
DB00730 Thiabendazole
DB00738 Pentamidine
DB00740 Riluzole
DB00755 Tretinoin
DB00783 Estradiol
DB00804 Dicyclomine
DB00816 Orciprenaline
DB00818 Propofol
DB00841 Dobutamine
DB00851 Dacarbazine
DB00852 Pseudoephedrine
DB00866 Alprenolol
DB00867 Ritodrine
DB00871 Terbutaline
DB00882 Clomifene
DB00889 Granisetron
DB00898 Ethanol
DB00901 Bitolterol
DB00908 Quinidine
DB00925 Phenoxybenzamine
DB00938 Salmeterol
DB00960 Pindolol
DB00972 Azelastine
DB00983 Formoterol
DB01001 Salbutamol
DB01013 Clobetasol
DB01026 Ketoconazole
DB01041 Thalidomide
DB01059 Norfloxacin
DB01064 Isoproterenol
DB01065 Melatonin
DB01087 Primaquine
DB01092 Ouabain
DB01095 Fluvastatin
DB01102 Arbutamine
DB01115 Nifedipine
DB01118 Amiodarone
DB01129 Rabeprazole
DB01136 Carvedilol
DB01151 Desipramine
DB01167 Itraconazole
DB01169 Arsenic trioxide
DB01174 Phenobarbital
DB01193 Acebutolol
DB01203 Nadolol
DB01210 Levobunolol
DB01214 Metipranolol
DB01234 Dexamethasone
DB01254 Dasatinib
DB01274 Arformoterol
DB01288 Fenoterol
DB01291 Pirbuterol
DB01295 Bevantolol
DB01297 Practolol
DB01359 Penbutolol
DB01363 Ephedra
DB01366 Procaterol
DB01388 Mibefradil
DB01393 Bezafibrate
DB01407 Clenbuterol
DB01408 Bambuterol
DB01580 Oxprenolol
DB02116 Olomoucine
DB02482 Phosphonothreonine
DB02709 Resveratrol
DB02733 Purvalanol
DB03783 Phenacetin
DB04338 SB220025
DB04840 Debrisoquin
DB04841 Flunarizine
DB04855 Dronedarone
DB04861 Nebivolol
DB04871 Lorcaserin
DB05039 Indacaterol
DB06216 Asenapine
DB06262 Droxidopa
DB06770 Benzyl alcohol
DB06877 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
DB07010 N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
DB07264 (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
DB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
DB07788 (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
DB07794 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
DB07905 (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
DB08059 (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
DB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
DB08521 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
DB08558 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
DB08807 Bopindolol
DB08808 Bupranolol
DB08846 Ellagic Acid
DB08893 Mirabegron
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