DT-Web: DB00277

Identification

Name

Theophylline

Accession Number

DB00277 (APRD00082)

Type

small molecule

Description

A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

180.164

Groups

approved

Monoisotopic Weight

180.06472552

Pharmacology

Indication

For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.

Mechanism of action

Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.

Absorption

Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form.

Protein binding

40%, primarily to albumin.

Biotransformation

Hepatic. Biotransformation takes place through demethylation to 1-methylxanthine and 3-methylxanthine and hydroxylation to 1,3-dimethyluric acid. 1-methylxanthine is further hydroxylated, by xanthine oxidase, to 1-methyluric acid. About 6% of a theophylline dose is N-methylated to caffeine. Caffeine and 3-methylxanthine are the only theophylline metabolites with pharmacologic activity.

Route of elimination

Theophylline does not undergo any appreciable pre-systemic elimination, distributes freely into fat-free tissues and is extensively metabolized in the liver. Renal excretion of unchanged theophylline in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults.

Toxicity

Symptoms of overdose include seizures, arrhythmias, and GI effects.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acyclovir	Acyclovir may increase the effect and toxicity of theophylline.
Adenosine	Theophylline may decrease the effect of adenosine.
Amobarbital	The barbiturate, amobarbital, decreases the effect of theophylline.
Aprobarbital	The barbiturate, aprobarbital, decreases the effect of theophylline.
Atracurium	Theophylline decreases the effect of the muscle relaxant
Bromazepam	Theophylline may decrease the therapeutic effect of bromazepam. Monitor for changes in the therapeutic effects of bromazepam if theophylline is initiated, discontinued or dose changed.
Butabarbital	The barbiturate, butabarbital, decreases the effect of theophylline.
Butalbital	The barbiturate, butalbital, decreases the effect of theophylline.
Butethal	The barbiturate, butethal, decreases the effect of theophylline.
Carbamazepine	Carbamazepine may decrease the serum concentration of theophylline. Theophylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Carteolol	Antagonism of action and increased effect of theophylline
Cimetidine	Cimetidine may increase the effect of theophylline.
Ciprofloxacin	Ciprofloxacin may increase the effect of theophylline.
Clarithromycin	Clarithromycin may increase the therapeutic and adverse effects of theophylline.
Dihydroquinidine barbiturate	The barbiturate, dihydroquinidine barbiturate, decreases the effect of theophylline.
Disulfiram	Disulfiram may increase the effect and toxicity of theophylline.
Doxacurium chloride	Theophylline decreases the effect of the muscle relaxant
Enoxacin	Enoxacin may increase the effect of theophylline.
Erythromycin	The macrolide, erythromycin, may increase the effect and toxicity of theophylline.
Ethinyl Estradiol	The contraceptive increases the effect and toxicity of theophylline
Ethotoin	Decreased effect of both products
Febuxostat	Coadministration of febuxostat with xanthine oxidase substrate drugs (azathioprine, mercaptopurine or theophylline) could increase plasma concentrations of these drugs, since these drugs are metabolized by xanthine oxidase, resulting in severe toxicity; hence their concomitant use is contraindicated. Since febuxostat does not inhibit or induce cytochrome P450 enzymes it lacks significant drug interactions with other drugs metabolized of these enzymes.
Fluvoxamine	Fluvoxamine may increase the therapeutic and adverse effects of theophylline.
Fosphenytoin	Decreased effect of both products
Grepafloxacin	Grepafloxacin may increase the effect of theophylline.
Halothane	Increased risk of cardiac arrhythmia
Heptabarbital	The barbiturate, heptabarbital, decreases the effect of theophylline.
Hexobarbital	The barbiturate, hexobarbital, decreases the effect of theophylline.
Interferon Alfa-2a, Recombinant	Interferon increases the effect and toxicity of theophylline
Interferon Alfa-2b, Recombinant	Interferon increases the effect and toxicity of theophylline
Interferon alfa-n1	Interferon increases the effect and toxicity of theophylline
Isoniazid	Isoniazid may increase the therapeutic and adverse effects of theophylline.
Josamycin	The macrolide, josamycin, may increase the effect and toxicity of theophylline.
Lithium	Theophylline decreases serum levels of lithium
Mephenytoin	Decreased effect of both products
Mestranol	The contraceptive increases the effect and toxicity of theophylline
Methohexital	The barbiturate, methohexital, decreases the effect of theophylline.
Methylphenobarbital	The barbiturate, methylphenobarbital, decreases the effect of theophylline.
Metocurine	Theophylline decreases the effect of the muscle relaxant
Mexiletine	Mexiletine increases the effect and toxicity of theophylline
Mivacurium	Theophylline decreases the effect of the muscle relaxant
Nadolol	Antagonism of action and increased effect of theophylline
Norfloxacin	Norfloxacin may increase the effect of theophylline.
Pancuronium	Theophylline decreases the effect of the muscle relaxant
Pefloxacin	Pefloxacin may increase the effect of theophylline.
Peginterferon alfa-2a	Interferon increases the effect and toxicity of theophylline
Peginterferon alfa-2b	Interferon increases the effect and toxicity of theophylline
Penbutolol	Antagonism of action and increased effect of theophylline
Pentobarbital	The barbiturate, pentobarbital, decreases the effect of theophylline.
Pentoxifylline	Pentoxifylline increases the effect and toxicity of theophylline
Phenobarbital	The barbiturate, phenobarbital, decreases the effect of theophylline.
Phenytoin	Decreased effect of both products
Pindolol	Antagonism of action and increased effect of theophylline
Primidone	The barbiturate, primidone, decreases the effect of theophylline.
Propafenone	Propafenone increases the effect of theophylline
Propranolol	Antagonism of action and increased effect of theophylline
Quinidine barbiturate	The barbiturate, quinidine barbiturate, decreases the effect of theophylline.
Regadenoson	Non-specific adenosine receptor antagonist may interfere with the vasodilation activity of regadenoson. Avoid methylxanthines for at least 12 hours before administration of regadenoson.
Rifampin	Rifampin decreases the effect of theophylline
Ritonavir	Ritonavir decreases the effect of theophylline
Rofecoxib	Rofecoxib increases the effect and toxicity of theophylline
Secobarbital	The barbiturate, secobarbital, decreases the effect of theophylline.
Sotalol	Antagonism of action and increased effect of theophylline
St. John's Wort	St. John's Wort decreases the effect of theophylline
Tacrine	Tacrine may reduce the elimination rate of Theophylline. Monitor for changes in the therapeutic and toxic effects of theophylline if Tacrine is initiated, discontinued or if the dose is changed.
Talbutal	The barbiturate, talbutal, decreases the effect of theophylline.
Telithromycin	Telithromycin may reduce clearance of Theophylline. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Theophylline if Telithromycin is initiated, discontinued or dose changed.
Temazepam	Theophylline may decrease the efficacy of Temazepam. Monitor for changes in the therapeutic effect of Temazepam if Theophylline is initiated, discontinued or dose changed.
Terbinafine	Terbinafine increases the effect and toxicity of theophylline
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Theophylline by decreasing Theophylline metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Theophylline if Thiabendazole is initiated, discontinued or dose changed.
Ticlopidine	Ticlopidine increases the effect and toxicity of theophylline
Timolol	Antagonism of action and increased effect of theophylline
Tipranavir	Tipranavir, co-administered with Ritonavir, may decrease the concentration of Theophylline.
Troleandomycin	The macrolide, troleandomycin, may increase the effect and toxicity of theophylline.
Tubocurarine	Theophylline decreases the effect of the muscle relaxant
Vecuronium	Theophylline decreases the effect of the muscle relaxant
Verapamil	Verapamil increases the effect of theophylline
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of theophylline by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of theophylline if voriconazole is initiated, discontinued or dose changed.
Zafirlukast	Zafirlukast serum concentrations may be decreased by Theophylline.
Zileuton	Zileuton may increase the therapeutic and adverse effects of theophylline by increasing its serum concentration. Monitor for changes in the therapeutic and adverse effects of theophylline if zileuton is initiated, discontinued or dose changed. Dose alterations should be considered.

Food Interactions

Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.

Adenosine A1 receptor
Name	Adenosine A1 receptor
Gene Name	ADORA1
Pharmacological action	yes
Actions	antagonist
References	Nantwi KD, Basura GJ, Goshgarian HG: Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection. J Spinal Cord Med. 2003 Winter;26(4):364-71. - Pubmed Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score	0.835
Adenosine A2a receptor
Name	Adenosine A2a receptor
Gene Name	ADORA2A
Pharmacological action	yes
Actions	antagonist
References	Pechlivanova DM, Georgiev VP: Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors. Methods Find Exp Clin Pharmacol. 2005 Nov;27(9):659-64. - Pubmed Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score	1.0361
Adenosine A2b receptor
Name	Adenosine A2b receptor
Gene Name	ADORA2B
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Philipp S, Yang XM, Cui L, Davis AM, Downey JM, Cohen MV: Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res. 2006 May 1;70(2):308-14. Epub 2006 Feb 23. - Pubmed Phelps PT, Anthes JC, Correll CC: Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. Eur J Pharmacol. 2006 Apr 24;536(1-2):28-37. Epub 2006 Mar 3. - Pubmed Fozard JR, Baur F, Wolber C: Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog. Eur J Pharmacol. 2003 Aug 15;475(1-3):79-84. - Pubmed Holgate ST: The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. Br J Pharmacol. 2005 Aug;145(8):1009-15. - Pubmed Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score	0.7186
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Name	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Gene Name	PDE4B
Pharmacological action	yes
Actions	inhibitor
References	Lipworth BJ: Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet. 2005 Jan 8-14;365(9454):167-75. - Pubmed
DTHybrid score	Not Available
cGMP-specific 3',5'-cyclic phosphodiesterase
Name	cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name	PDE5A
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	Not Available
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Name	cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Gene Name	PDE4A
Pharmacological action	yes
Actions	inhibitor
References	Wang K, Chen JQ, Chen Z, Chen JC: Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45. Acta Pharmacol Sin. 2002 Nov;23(11):1013-7. - Pubmed Haider S: Cyclic AMP level and phosphodiesterase activity during 17alpha,20beta-dihydroxy-4-pregnen-3-one induction and theophylline inhibition of oocyte maturation in the catfish, Clarias batrachus. Comp Biochem Physiol A Mol Integr Physiol. 2003 Feb;134(2):267-74. - Pubmed Rickards KJ, Andrews MJ, Waterworth TH, Alexander GB, Cunningham FM: Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation. J Vet Pharmacol Ther. 2003 Aug;26(4):277-82. - Pubmed Usta C, Sadan G, Tuncel B: The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations. Prostaglandins Leukot Essent Fatty Acids. 2004 Sep;71(3):137-41. - Pubmed Lee JM, Zemans RL, Hejazi M, Chin BB, Ladenson PW, Caturegli P: Modulation of thyroidal radioiodine uptake by theophylline. Exp Mol Pathol. 2004 Oct;77(2):116-20. - Pubmed
DTHybrid score	Not Available
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Name	cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Gene Name	PDE3A
Pharmacological action	yes
Actions	inhibitor
References	Rickards KJ, Andrews MJ, Waterworth TH, Alexander GB, Cunningham FM: Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation. J Vet Pharmacol Ther. 2003 Aug;26(4):277-82. - Pubmed Wu BN, Lin RJ, Lo YC, Shen KP, Wang CC, Lin YT, Chen IJ: KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug;142(7):1105-14. Epub 2004 Jul 5. - Pubmed Kajikawa S, Kigami D, Nakayama H, Doi K: Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline. Exp Anim. 2006 Apr;55(2):143-6. - Pubmed
DTHybrid score	Not Available
Histone deacetylase 2
Name	Histone deacetylase 2
Gene Name	HDAC2
Pharmacological action	yes
Actions	activator
References	Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, Barnes PJ: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. Epub 2002 Jun 17. - Pubmed Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ: Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med. 2004 Sep 6;200(5):689-95. Epub 2004 Aug 30. - Pubmed
DTHybrid score	0.3667

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8299
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. - Pubmed Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Sarkar MA, Hunt C, Guzelian PS, Karnes HT: Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metab Dispos. 1992 Jan-Feb;20(1):31-7. - Pubmed
DTHybrid score	0.7463
Adenosine deaminase
Name	Adenosine deaminase
Gene Name	ADA
Actions	inhibitor,inducer
References	- Saboury AA, Bagheri S, Ataie G, Amanlou M, Moosavi-Movahedi AA, Hakimelahi GH, Cristalli G, Namaki S: Binding properties of adenosine deaminase interacted with theophylline. Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1179-82. - Pubmed Singh LS, Sharma R: Purification and characterization of intestinal adenosine deaminase from mice. Mol Cell Biochem. 2000 Jan;204(1-2):127-34. - Pubmed Bandyopadhyay BC, Poddar MK: Theophylline-induced changes in mammalian adenosine deaminase activity and corticosterone status: possible relation to immune response. Methods Find Exp Clin Pharmacol. 1997 Apr;19(3):181-4. - Pubmed
DTHybrid score	1.4671
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Sarkar MA, Hunt C, Guzelian PS, Karnes HT: Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metab Dispos. 1992 Jan-Feb;20(1):31-7. - Pubmed
DTHybrid score	0.4557
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3828
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2467
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4296
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5617
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.577

Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T: Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. Epub 2005 Feb 11. - Pubmed
DTHybrid score	0.2575

Id	Partner name	Gene Name	Score
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.4465
6016	Cytochrome P450 2C19	CYP2C19	0.3594
1588	Multidrug resistance protein 1	ABCB1	0.3188
4118	Cytochrome P450 3A5	CYP3A5	0.2912
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.2296
390	Adenosine A3 receptor	ADORA3	0.2132
6030	Cytochrome P450 2B6	CYP2B6	0.1991
6107	Cytochrome P450 3A7	CYP3A7	0.1978
5718	Cytochrome P450 2A6	CYP2A6	0.1466
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1189
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.1162
587	Serum albumin	ALB	0.1148
20	Prostaglandin G/H synthase 1	PTGS1	0.114
1729	Solute carrier family 22 member 6	SLC22A6	0.1056
6021	Adenosine kinase	ADK	0.0984
1830	5'-nucleotidase	NT5E	0.0962
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.094
6171	Solute carrier family 28 member 3	SLC28A3	0.093
6142	Solute carrier family 22 member 8	SLC22A8	0.0919
492	Histamine H1 receptor	HRH1	0.0842
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0842
777	Tumor necrosis factor	TNF	0.0837
3811	Cytochrome P450 19A1	CYP19A1	0.0829
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0815
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.081
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0754
5360	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	0.0738
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0733
290	Prostaglandin G/H synthase 2	PTGS2	0.0716
2164	Multidrug resistance-associated protein 4	ABCC4	0.0715
862	Multidrug resistance-associated protein 1	ABCC1	0.0715
6106	Cytochrome P450 2C18	CYP2C18	0.0687
1024	Solute carrier family 22 member 11	SLC22A11	0.0662
4121	Histone deacetylase 1	HDAC1	0.0633
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0609
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0596
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0595
6136	Multidrug resistance-associated protein 5	ABCC5	0.0592
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0589
824	Sodium-dependent serotonin transporter	SLC6A4	0.0589
6145	Solute carrier family 22 member 1	SLC22A1	0.0587
4123	Histone deacetylase 3	HDAC3	0.0556
776	Bile salt export pump	ABCB11	0.0539
4124	Histone deacetylase 6	HDAC6	0.0535
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0529
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0527
6144	Solute carrier family 22 member 2	SLC22A2	0.0523
831	D(2) dopamine receptor	DRD2	0.0514
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0506
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0503
556	Alpha-1A adrenergic receptor	ADRA1A	0.0482
136	Estrogen receptor	ESR1	0.0466
4762	Acetoin utilization protein	acuC1	0.0464
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0455
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0447
3947	Xanthine dehydrogenase/oxidase	XDH	0.0445
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0439
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.043
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0427
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0427
318	Alpha-2A adrenergic receptor	ADRA2A	0.042
468	Cytochrome P450 4A11	CYP4A11	0.0417
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0414
901	Glutathione S-transferase Mu 4	GSTM4	0.0401
118	Organic cation/carnitine transporter 2	SLC22A5	0.04
6044	Serum paraoxonase/lactonase 3	PON3	0.0396
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0388
766	Beta-2 adrenergic receptor	ADRB2	0.0387
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.038
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0378
814	Ryanodine receptor 1	RYR1	0.0376
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0369
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0369
2921	Histone deacetylase 8	HDAC8	0.0366
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0364
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0363
193	Beta-1 adrenergic receptor	ADRB1	0.036
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0359
23	D(1A) dopamine receptor	DRD1	0.0356
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0355
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0352
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0347
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0345
3941	Amine oxidase [flavin-containing] A	MAOA	0.0345
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0339
817	DNA topoisomerase 2-alpha	TOP2A	0.0337
6148	Multidrug resistance-associated protein 7	ABCC10	0.0332
6147	Solute carrier family 22 member 3	SLC22A3	0.0328
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0326
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0324
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0324
871	Glucocorticoid receptor	NR3C1	0.0323
6031	Cytochrome P450 3A43	CYP3A43	0.032
713	Sodium-dependent dopamine transporter	SLC6A3	0.0313
632	Alpha-1B adrenergic receptor	ADRA1B	0.0308
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0298
847	Mu-type opioid receptor	OPRM1	0.0296
465	Calmodulin	CALM1	0.0295
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0292
833	Organic cation/carnitine transporter 1	SLC22A4	0.0286
509	Thymidine kinase	TK	0.0282
570	Thymidine kinase	TK	0.0282
2559	Thymidine kinase	TK	0.0282
3430	Thymidine kinase	tdk	0.0282
3518	Thymidine kinase	TK	0.0282
5301	Thymidine kinase	tdk	0.0282
5771	Thymidine kinase	ORF36	0.0282
7009	Thymidine kinase	ORF36	0.0282
260	Cytochrome P450 51	ERG11	0.0279
761	Cytochrome P450 51	ERG11	0.0279
3163	Cytochrome P450 51	cyp51	0.0279
6083	Deoxyguanosine kinase, mitochondrial	DGUOK	0.0278
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0265
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0263
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0263
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0263
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0261
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0261
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0261
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.026
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.026
36	Insulin receptor	INSR	0.0258
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0256
3923	Cholinesterase	BCHE	0.0251
467	Delta-type opioid receptor	OPRD1	0.025
527	Prostacyclin receptor	PTGIR	0.0248
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0245
731	HIV-1 protease	HIV-1 protease	0.0244
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0243
638	D(3) dopamine receptor	DRD3	0.0242
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.024
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.024
696	Kappa-type opioid receptor	OPRK1	0.0238
6014	Cytochrome P450 2A13	CYP2A13	0.0236
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0235
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0234
6141	Sodium/bile acid cotransporter	SLC10A1	0.0231
6220	Aryl hydrocarbon receptor	AHR	0.0231
3939	Amine oxidase [flavin-containing] B	MAOB	0.0229
4773	Deoxycytidine kinase	DCK	0.0227
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0226
146	Androgen receptor	AR	0.0219
629	Alpha-2B adrenergic receptor	ADRA2B	0.0215
474	Acetylcholinesterase	ACHE	0.0212
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0212
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0209
603	DNA polymerase alpha catalytic subunit	POLA1	0.0209
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0208
789	Alpha-1D adrenergic receptor	ADRA1D	0.0203
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0203
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0203
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0202
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0197
1757	Myeloperoxidase	MPO	0.0196
891	Dihydropteroate synthase	folP	0.0196
5359	Dihydropteroate synthase	folP	0.0196
7175	Dihydropteroate synthase	sulI	0.0196
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0195
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0194
4228	Keratin, type II cytoskeletal 7	KRT7	0.0194
378	Alpha-2C adrenergic receptor	ADRA2C	0.0193
122	P2Y purinoceptor 12	P2RY12	0.0193
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0192
6020	Aldehyde oxidase	AOX1	0.0185
4203	Histamine N-methyltransferase	HNMT	0.0184
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0183
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0183
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0179
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0177
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0177
29	Tubulin beta-1 chain	TUBB1	0.0175
1792	Tissue-type plasminogen activator	PLAT	0.0175
432	D(4) dopamine receptor	DRD4	0.0175
380	Cytochrome P450 17A1	CYP17A1	0.0174
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0172
1010	Cytochrome P450 51A1	CYP51A1	0.0172
6137	Multidrug resistance-associated protein 6	ABCC6	0.0171
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0169
844	Epidermal growth factor receptor	EGFR	0.0169
2256	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	0.0168
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0168
6182	Cytochrome P450 2J2	CYP2J2	0.0164
6102	Arylamine N-acetyltransferase 2	NAT2	0.0163
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0163
144	Hemoglobin subunit alpha	HBA1	0.0163
477	DNA topoisomerase 4 subunit A	parC	0.0162
886	DNA topoisomerase 4 subunit A	parC	0.0162
6226	DNA topoisomerase 4 subunit A	parC	0.0162
4604	Liver carboxylesterase 1	CES1	0.0161
404	DNA gyrase subunit A	gyrA	0.016
6224	DNA gyrase subunit A	gyrA	0.016
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0159
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0157
738	Monocarboxylate transporter 1	SLC16A1	0.0157
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0157
572	Integrin alpha-L	ITGAL	0.0152
504	Mast/stem cell growth factor receptor	KIT	0.0152
273	Apoptosis regulator Bcl-2	BCL2	0.0151
70	Type-1 angiotensin II receptor	AGTR1	0.0149
373	Transthyretin	TTR	0.0148
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0147
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0147
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0146
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0144
869	Estrogen receptor beta	ESR2	0.0144
94	5-hydroxytryptamine 4 receptor	HTR4	0.0143
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0142
818	50S ribosomal protein L10	rplJ	0.0142
811	Translocator protein	TSPO	0.0141
2516	GMP reductase 1	GMPR	0.0141
2361	Response regulator pleD	pleD	0.0141
571	Melatonin receptor type 1A	MTNR1A	0.0137
362	Melatonin receptor type 1B	MTNR1B	0.0137
614	Progesterone receptor	PGR	0.0136
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0135
4106	Guanylate kinase	GUK1	0.0135
4516	Guanylate kinase	gmk	0.0135
1629	Transcription factor AP-1	JUN	0.0133
482	Glycine receptor subunit alpha-1	GLRA1	0.0133
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0133
365	Dihydrofolate reductase	DHFR	0.0131
2381	Dihydrofolate reductase	DFR1	0.0131
2833	Dihydrofolate reductase	Not Available	0.0131
2931	Dihydrofolate reductase	folA	0.0131
3544	Dihydrofolate reductase	folA	0.0131
3682	Dihydrofolate reductase	folA	0.0131
6642	Dihydrofolate reductase	folA	0.0131
6756	Dihydrofolate reductase	dfrA	0.0131
4116	Dihydropteroate synthetase	Not Available	0.0131
756	Sex hormone-binding globulin	SHBG	0.013
140	30S ribosomal protein S9	rpsI	0.013
6719	30S ribosomal protein S9	rpsI	0.013
6725	30S ribosomal protein S9	rpsI	0.013
790	DNA polymerase subunit alpha B	POLA2	0.0129
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0128
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0128
4120	NADPH--cytochrome P450 reductase	POR	0.0127
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0124
24	Thymidylate synthase	TMP1	0.0123
359	Thymidylate synthase	TYMS	0.0123
2626	Thymidylate synthase	thyA	0.0123
2729	Thymidylate synthase	thyA	0.0123
5352	Thymidylate synthase	THYA	0.0123
1852	Microtubule-associated protein 2	MAP2	0.0123
5923	Microtubule-associated protein tau	MAPT	0.0122
5924	Microtubule-associated protein 4	MAP4	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0121
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.012
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0118
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0117
716	5-hydroxytryptamine 7 receptor	HTR7	0.0117
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0117
48	Pyridoxal kinase	PDXK	0.0116
1517	Beta-3 adrenergic receptor	ADRB3	0.0115
275	Arachidonate 5-lipoxygenase	ALOX5	0.0115
295	Carbonic anhydrase 1	CA1	0.0115
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0113
2449	Tubulin alpha-3 chain	TUBA1A	0.0113
2966	PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase	pyrR	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
22	30S ribosomal protein S4	rpsD	0.0113
6714	30S ribosomal protein S4	rpsD	0.0113
2499	Tubulin beta-2C chain	TUBB2C	0.0113
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0112
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0109
163	D(1B) dopamine receptor	DRD5	0.0108
3932	Glutathione S-transferase A2	GSTA2	0.0107
3300	Xanthine phosphoribosyltransferase	xpt	0.0107
3681	Xanthine phosphoribosyltransferase	gpt	0.0107
6146	High affinity copper uptake protein 1	SLC31A1	0.0107
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0106
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0106
1192	Sulfotransferase 1A1	SULT1A1	0.0106
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0105
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0103
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0103
183	Vascular endothelial growth factor A	VEGFA	0.0103
124	Histamine H2 receptor	HRH2	0.0102
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0101
592	Carbonic anhydrase 4	CA4	0.0101
1714	Mitogen-activated protein kinase 3	MAPK3	0.0101
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0099
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0099
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0099
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0099
705	Glutamate receptor 1	GRIA1	0.0098
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0098
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0098
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
3810	Catechol O-methyltransferase	COMT	0.0097
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0096
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0096
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0096
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0096
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0096
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0096
407	Vascular endothelial growth factor receptor 2	KDR	0.0094
159	Penicillin-binding protein 2B	penA	0.0093
6121	Penicillin-binding protein 2B	penA	0.0093
737	Mineralocorticoid receptor	NR3C2	0.0093
4237	50S ribosomal protein L22	rplV	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0092
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0092
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0091
921	Glutamate receptor 2	GRIA2	0.0091
161	Tubulin beta chain	TUBB	0.0091
312	Tubulin beta chain	TUB2	0.0091
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0091
6766	O-GlcNAcase BT_4395	BT_4395	0.0089
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0089
2236	Casein kinase II subunit alpha	CSNK2A1	0.0089
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
952	Dipeptidyl peptidase 4	DPP4	0.0088
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0088
904	Glutathione S-transferase P	GSTP1	0.0088
5353	Glutamate decarboxylase alpha	gadA	0.0087
6043	Putative G-protein coupled receptor 44	GPR44	0.0087
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0086
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0086
6085	Fatty acid-binding protein, intestinal	FABP2	0.0086
1569	G1/S-specific cyclin-D1	CCND1	0.0085
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0085
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0085
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0085
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0084
84	Nuclear receptor 0B1	NR0B1	0.0084
1050	Bile salt sulfotransferase	SULT2A1	0.0083
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0083
823	Fibroblast growth factor receptor 2	FGFR2	0.0081
6149	Solute carrier family 22 member 10	SLC22A10	0.0081
338	DNA polymerase	UL30	0.0081
379	DNA polymerase	UL54	0.0081
697	DNA polymerase	ORF28	0.0081
2482	DNA polymerase	43	0.0081
4104	DNA polymerase	BALF5	0.0081
4238	50S ribosomal protein L4	rplD	0.0081
5578	50S ribosomal protein L4	rplD	0.0081
6173	50S ribosomal protein L4	rplD	0.0081
6219	50S ribosomal protein L4	rplD	0.0081
6126	Carbonic anhydrase 7	CA7	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
284	DNA-directed RNA polymerase beta chain	rpoB	0.008
5773	DNA-directed RNA polymerase beta chain	rpoB	0.008
4311	tRNA	TRDMT1	0.0079
4325	tRNA	trmD	0.0079
4328	tRNA	trmD	0.0079
3937	Fatty-acid amide hydrolase	FAAH	0.0079
908	Glutathione S-transferase theta-1	GSTT1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
3830	Calreticulin	CALR	0.0078
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0078
26	Vascular endothelial growth factor receptor 3	FLT4	0.0077
1867	Major prion protein	PRNP	0.0077
1176	Mitogen-activated protein kinase 1	MAPK1	0.0077
518	Peroxidase/catalase T	katG	0.0076
820	Glycine receptor subunit alpha-2	GLRA2	0.0076
1275	Estrogen sulfotransferase	SULT1E1	0.0076
6033	High affinity interleukin-8 receptor A	CXCR1	0.0076
357	Carbonic anhydrase 2	CA2	0.0076
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0075
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0075
88	Retinoic acid receptor RXR-beta	RXRB	0.0075
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0075
4192	DNA topoisomerase 2-beta	TOP2B	0.0075
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0074
1541	Metalloproteinase	mmp20	0.0074
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0074
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0074
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0074
32	Vascular endothelial growth factor receptor 1	FLT1	0.0073
6034	Hydroxyindole O-methyltransferase	ASMT	0.0073
6035	Nuclear receptor ROR-beta	RORB	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
6036	Eosinophil peroxidase	EPX	0.0073
1656	CYP2B protein	CYP2B	0.0073
251	Alcohol dehydrogenase 1A	ADH1A	0.0072
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
427	Substance-P receptor	TACR1	0.0072
2286	Isocitrate dehydrogenase [NADP]	icd	0.0072
2302	Isocitrate dehydrogenase [NADP]	icd	0.0072
2771	Isocitrate dehydrogenase [NADP]	icd	0.0072
5934	Cytochrome P450 26A1	CYP26A1	0.0071
444	Alcohol dehydrogenase 1B	ADH1B	0.0071
68	Cannabinoid receptor 1	CNR1	0.007
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.007
49	Endothelin B receptor	EDNRB	0.0069
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0068
469	Annexin A1	ANXA1	0.0068
634	Squalene monooxygenase	SQLE	0.0068
7196	Squalene monooxygenase	ERG1	0.0068
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0067
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0067
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0067
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
856	Vitamin D3 receptor	VDR	0.0067
5691	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC	rmlC	0.0067
3361	Serpin B5	SERPINB5	0.0067
153	Dopamine beta-hydroxylase	DBH	0.0067
5694	Transcription antiterminator licT	licT	0.0067
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0067
936	Ephrin type-A receptor 2	EPHA2	0.0067
33	Cystine/glutamate transporter	SLC7A11	0.0067
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0067
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0066
6207	30S ribosomal protein S14	rpsN	0.0066
6209	30S ribosomal protein S19	rpsS	0.0066
6712	30S ribosomal protein S19	rpsS	0.0066
6726	30S ribosomal protein S19	rpsS	0.0066
558	Solute carrier family 12 member 1	SLC12A1	0.0066
517	Alcohol dehydrogenase 1C	ADH1C	0.0066
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0065
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0065
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
976	Platelet glycoprotein IX	GP9	0.0065
3809	Estrogen-related receptor gamma	ESRRG	0.0065
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0065
7	Nitric oxide synthase, inducible	NOS2	0.0064
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
765	Indoleamine 2,3-dioxygenase	IDO1	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
1648	Elastin	ELN	0.0063
3685	Catabolite gene activator	crp	0.0063
4655	Adenylate cyclase	cyaC	0.0063
4759	Adenylate cyclase	cyaB2	0.0063
164	Histamine H4 receptor	HRH4	0.0063
133	Dihydropterate synthase	sulI	0.0063
6163	Copper-transporting ATPase 2	ATP7B	0.0062
6165	Copper-transporting ATPase 1	ATP7A	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
1291	cAMP response element-binding protein	CREB1	0.0061
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0061
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0061
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0061
65	Matrix metalloproteinase-9	Not Available	0.0061
581	Cytochrome P450 2R1	CYP2R1	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.006
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
780	Retinoic acid receptor RXR-gamma	RXRG	0.0059
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0058
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
6138	Multidrug resistance protein 3	ABCB4	0.0058
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0058
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
896	Glutathione S-transferase Mu 1	GSTM1	0.0057
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0057
4226	Uridine phosphorylase 2	UPP2	0.0057
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0056
128	Adenine phosphoribosyltransferase	APRT	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
244	Angiotensin-converting enzyme	ACE	0.0056
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0055
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0055
563	Thyroid peroxidase	TPO	0.0055
6506	Stathmin-4	STMN4	0.0055
1374	Natriuretic peptides B	NPPB	0.0054
1827	Gap junction alpha-1 protein	GJA1	0.0054
1908	Vascular cell adhesion protein 1	VCAM1	0.0054
2249	Aspartate aminotransferase	aspC	0.0054
2671	Aspartate aminotransferase	aspC	0.0054
5490	Aspartate aminotransferase	Not Available	0.0054
3639	Thymidine phosphorylase	deoA	0.0054
3936	Thymidine phosphorylase	TYMP	0.0054
4217	Telomerase reverse transcriptase	TERT	0.0054
484	Tyrosine-protein kinase ABL2	ABL2	0.0054
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0054
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0054
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0054
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0054
4760	Mll3241 protein	mll3241	0.0054
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0052
712	Tubulin alpha chain	TUB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
4225	Uridine phosphorylase 1	UPP1	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0051
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0051
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0051
4103	Proteasome subunit beta type 2	PSMB2	0.0051
54	Prothrombin	F2	0.0051
4102	Proteasome subunit beta type 5	PSMB5	0.0051
4101	Proteasome subunit beta type 1	PSMB1	0.0051
239	Coagulation factor X	F10	0.0051
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0051
174	Sigma 1-type opioid receptor	SIGMAR1	0.005
162	Retinoic acid receptor gamma-1	RARG	0.005
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.005
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.005
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
413	Amidophosphoribosyltransferase	PPAT	0.0049
2515	Amidophosphoribosyltransferase	purF	0.0049
3714	Amidophosphoribosyltransferase	purF	0.0049
851	5'-AMP-activated protein kinase subunit beta-2	PRKAB2	0.0049
388	AMP deaminase 1	AMPD1	0.0049
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0049
672	Prostaglandin F2-alpha receptor	PTGFR	0.0049
3404	Exotoxin A	eta	0.0049
4534	Cytohesin-2	CYTH2	0.0048
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0048
1618	High affinity nerve growth factor receptor	NTRK1	0.0048
1483	Membrane copper amine oxidase	AOC3	0.0048
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0047
1992	Vitamin D-binding protein	GC	0.0047
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0047
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0047
3668	Maltose-binding periplasmic protein precursor	malE	0.0047
6432	Transporter	snf	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
2230	Catalase	CAT	0.0046
3249	Catalase	katA	0.0046
3625	Catalase	katA	0.0046
4539	Catalase	katA	0.0046
4941	Catalase	katB	0.0046
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0046
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0046
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0046
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0046
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0046
867	Penicillin-binding protein 3	pbpC	0.0046
6119	Penicillin-binding protein 3	pbp3	0.0046
7154	Penicillin-binding protein 3	pbp3	0.0046
7157	Penicillin-binding protein 3	LMHCC_2184	0.0046
7162	Penicillin-binding protein 3	pbpB	0.0046
7172	Penicillin-binding protein 3	pbp3	0.0046
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
1654	Interleukin-1 beta	IL1B	0.0045
3086	Plasmepsin-2	Not Available	0.0045
3856	Fibroblast growth factor receptor 3	FGFR3	0.0045
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0045
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
130	Prostacyclin synthase	PTGIS	0.0044
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0044
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0044
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0044
106	Cannabinoid receptor 2	CNR2	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0042
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0042
319	Opioid receptor, sigma 1	OPRS1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
751	Potassium channel subfamily K member 6	KCNK6	0.0042
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0042
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0042
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0042
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0042
297	Adenylate cyclase type 1	ADCY1	0.0042
663	Solute carrier family 12 member 4	SLC12A4	0.0042
53	Solute carrier family 12 member 5	SLC12A5	0.0042
2592	Beta-galactosidase	lacZ	0.0042
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0042
2320	Thymidine kinase, cytosolic	TK1	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
1039	Histone deacetylase 9	HDAC9	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
1507	Cytochrome c	CYCS	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3808	Dihydropteroate synthase 2	folP2	0.0041
3601	Dihydropteroate synthase 1	folP1	0.0041
3807	Dihydropteroate synthase 1	folP1	0.0041
411	Glycine N-methyltransferase	GNMT	0.004
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
315	Arginase-1	ARG1	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
569	Retinal dehydrogenase 2	ALDH1A2	0.0039
310	Solute carrier family 12 member 2	SLC12A2	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
172	Potassium channel subfamily K member 1	KCNK1	0.0039
1123	Eosinophil cationic protein	RNASE3	0.0038
4198	Fructose-1,6-bisphosphatase 1	FBP1	0.0038
165	FL cytokine receptor	FLT3	0.0038
400	Coagulation factor IX	F9	0.0037
5461	Coagulation factor IX	F9	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
822	Aldose reductase	AKR1B1	0.0037
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
611	Retinal dehydrogenase 1	ALDH1A1	0.0037
6218	Pannexin-1	PANX1	0.0036
494	Caspase-1	CASP1	0.0036
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0036
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0036
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
10	Glycogen phosphorylase, liver form	PYGL	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0035
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0035
293	Gamma-glutamyl hydrolase	GGH	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0034
604	Vitamin K-dependent protein Z	PROZ	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0034
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0034
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0033
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
229	Retinoic acid receptor beta	RARB	0.0033
6167	Organic solute transporter subunit beta	OSTB	0.0033
6166	Organic solute transporter subunit alpha	OSTA	0.0033
3760	Penicillin-binding protein 5 precursor	dacA	0.0033
730	Retinoic acid receptor alpha	RARA	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
645	Penicillin-binding protein 1A	mrcA	0.0032
5805	Penicillin-binding protein 1A	ponA	0.0032
6185	Penicillin-binding protein 1A	mrcA	0.0032
6799	Penicillin-binding protein 1A	pbpA	0.0032
6131	Carbonic anhydrase 14	CA14	0.0032
719	Retinoic acid receptor responder protein 1	RARRES1	0.0032
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0032
770	Retinoic acid-induced protein 3	GPRC5A	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
5787	Angiopoietin-1 receptor	TEK	0.0031
422	Vitamin K-dependent protein C	PROC	0.0031
1245	Vitamin K-dependent protein S	PROS1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
1196	Complement decay-accelerating factor	CD55	0.0031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0031
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0031
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
4992	Cytochrome c peroxidase	Not Available	0.003
291	Nitric-oxide synthase, endothelial	NOS3	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
3913	Glutamic acid decarboxylase	GAD65	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1650	Heme carrier protein 1	SLC46A1	0.003
2077	Caspase-3	CASP3	0.003
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6122	Carbonic anhydrase 3	CA3	0.003
819	Penicillin-binding protein 4	dacB	0.0029
2298	Cytochrome P450-cam	camC	0.0029
489	Monocarboxylate transporter 2	SLC16A7	0.0029
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0029
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0029
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
6168	Solute carrier family 22 member 16	SLC22A16	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
267	Plasminogen activator inhibitor 1	SERPINE1	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0028
5590	N utilization substance protein B homolog	nusB	0.0028
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0028
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0028
5591	Complement component C8 gamma chain	C8G	0.0028
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0028
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0028
5587	Iron(III)-binding periplasmic protein	fbpA	0.0028
2838	Ribose-5-phosphate isomerase A	rpiA	0.0028
2952	Ribose-5-phosphate isomerase A	rpiA	0.0028
5595	Ribose-5-phosphate isomerase A	rpiA	0.0028
4695	UPF0124 protein yfiH	yfiH	0.0028
5060	Intron-associated endonuclease 1	ITEVIR	0.0028
5593	Transferase	Not Available	0.0028
5581	Beta-fructosidase	bfrA	0.0028
5588	Cell division protein FtsY	TM_0570	0.0028
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0028
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0028
5600	Pyruvate decarboxylase	pdc	0.0028
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0028
4375	Glutamine synthetase 1	glnA1	0.0028
5575	Short tail fiber protein	12	0.0028
5574	Invasin	YPTB1668	0.0028
5580	Hexon protein	PII	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
115	Penicillin-binding protein 2	mrdA	0.0027
6069	Penicillin-binding protein 2	mrdA	0.0027
6118	Penicillin-binding protein 2	penA	0.0027
6187	Penicillin-binding protein 2	pbpA	0.0027
6686	Penicillin-binding protein 2	pbp2	0.0027
6939	Penicillin-binding protein 2	mrdA	0.0027
7163	Penicillin-binding protein 2	pbpA	0.0027
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0027
2808	Chloramphenicol acetyltransferase 3	cat3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
1630	Integrin beta-2	ITGB2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0027
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0027
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0026
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0026
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0026
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0026
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0026
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0026
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0026
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0026
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0026
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0026
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0026
543	Penicillin-binding protein 1B	mrcB	0.0026
6186	Penicillin-binding protein 1B	ponB	0.0026
6822	Penicillin-binding protein 1b	pbp1b	0.0026
6844	Penicillin-binding protein 1b	pbp1b	0.0026
1	Peptidoglycan synthetase ftsI	ftsI	0.0025
4155	Peptidoglycan synthetase ftsI	ftsI	0.0025
735	Alanine aminotransferase 1	GPT	0.0025
3904	Alanine aminotransferase 2	GPT2	0.0025
798	Osteocalcin	BGLAP	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
6221	Steroid hormone receptor ERR1	ESRRA	0.0025
2417	Chloramphenicol acetyltransferase	cat	0.0025
3278	Chloramphenicol acetyltransferase	cat	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
2810	Dr hemagglutinin structural subunit	draA	0.0025
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0025
3132	Tryptophan synthase alpha chain	trpA	0.0025
6568	Tryptophan synthase alpha chain	trpA	0.0025
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0024
3729	Citrate synthase	gltA	0.0024
4575	Citrate synthase	cit	0.0024
4580	Citrate synthase	gltA	0.0024
5328	Prostaglandin F synthase	Tb11.02.2310	0.0024
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0024
5006	RNASE4 protein	RNASE4	0.0024
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0024
2555	Pol polyprotein	pol	0.0024
3242	Pol polyprotein	gag-pol	0.0024
3471	Pol polyprotein	gag-pro-pol	0.0024
5256	Pol polyprotein	pol	0.0024
6469	Pol polyprotein	gag-pol	0.0024
6565	Pol polyprotein	Not Available	0.0024
4533	Glyoxalase family protein	BC_1747	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0024
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0024
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0024
6070	Nischarin	NISCH	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6042	Prostaglandin reductase 2	PTGR2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6048	Troponin C, skeletal muscle	TNNC2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
369	Coagulation factor VII	F7	0.0023
2521	Cell division protein ftsZ	ftsZ	0.0023
3301	Cell division protein ftsZ	ftsZ	0.0023
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0023
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0022
2603	Beta-lactamase II	blm	0.0022
2149	Angiogenin	ANG	0.0022
3583	6-phosphogluconolactonase	pgl	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
2207	Rhodopsin	RHO	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
857	Malate dehydrogenase, mitochondrial	MDH2	0.0021
332	Beta-lactamase	blaZ	0.0021
2478	Beta-lactamase	ampC	0.0021
2613	Beta-lactamase	ampC	0.0021
2635	Beta-lactamase	ampC	0.0021
2700	Beta-lactamase	penP	0.0021
5445	Beta-lactamase	blaB	0.0021
6019	Beta-lactamase	SHV-7	0.0021
6701	Beta-lactamase	cphA	0.0021
6824	Tyrosine-protein kinase Lyn	LYN	0.0021
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0021
3007	Carbonic anhydrase 12	CA12	0.0021
4205	Carbonic anhydrase 9	CA9	0.0021
3486	Fumarate hydratase class II	fumC	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
2942	Sialidase	nanH	0.0021
3546	Sialidase	nedA	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.002
3868	Calcineurin subunit B isoform 2	PPP3R2	0.002
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.002
2697	Uridine-cytidine kinase 2	UCK2	0.002
594	Thyroxine-binding globulin	SERPINA7	0.002
2452	Tryptophanyl-tRNA synthetase	trpS	0.002
5818	Folate receptor alpha	FOLR1	0.002
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
76	Nitric-oxide synthase, brain	NOS1	0.002
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.002
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.002
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0019
2216	Fibroblast growth factor receptor 4	FGFR4	0.0019
2408	Tyrosine-protein kinase SYK	SYK	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
760	Fibroblast growth factor 1	FGF1	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0019
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0019
5579	Carboxypeptidase B	CPB1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1864	RET proto-oncogene	RET	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
3384	Macrophage migration inhibitory factor	MIF	0.0018
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0018
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0018
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0018
2391	Ferrochelatase	hemH	0.0018
6502	Ferrochelatase	DKFZp686P18130	0.0018
1591	Ferrochelatase, mitochondrial	FECH	0.0018
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0018
1313	Lactoylglutathione lyase	GLO1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
6459	Glycodelin	PAEP	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
3221	Cytochrome c4	cc4	0.0016
1243	Cathepsin D	CTSD	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0016
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0016
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0016
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0016
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0016
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0016
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0016
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0016
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0016
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0016
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0016
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0016
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0016
6558	Cytochrome c oxidase subunit 1	ctaD	0.0016
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0016
6559	Cytochrome c oxidase subunit 2	ctaC	0.0016
6669	Cytochrome c oxidase subunit 2	ctaC	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
3587	Gastrotropin	FABP6	0.0015
2540	Choloylglycine hydrolase	cbh	0.0014
5682	Ribonuclease pancreatic	RNASE1	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
6859	Protein S100-A4	S100A4	0.0014
6501	Fatty acid-binding protein, liver	FABP1	0.0014
2021	Thrombomodulin	THBD	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
6500	Phospholipase A2	PLA2G1B	0.0011
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
283	SEC14-like protein 2	SEC14L2	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6151	Monocarboxylate transporter 10	SLC16A10	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6677	Myelin P2 protein	PMP2	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2240	Cell division protein kinase 2	CDK2	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00277 - Theophylline

Targets

Enzymes

Transporters

Predictions