DT-Web

DB00532 - Mephenytoin


Identification
Name Mephenytoin
Accession Number DB00532 (APRD00512)
Type small molecule
Description Mephenytoin is a hydantoin-derivative anticonvulsant used to control various partial seizures. It is generally reserved for treatment of individuals refractory to less toxic agents. Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias compared to other anticonvulsants. As such, these agents should not be used concurrently.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 218.2518
Groups approved
Monoisotopic Weight 218.105527702
Pharmacology
Indication For the treatment of refractory partial epilepsy.
Mechanism of action The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Alprazolam Mephenytoin may increase the metabolism of alprazolam via CYP3A4.
Aminophylline Decreased effect of both products
Amiodarone Increases the effect of hydantoin
Aprepitant The CYP3A4 inducer, mephenytoin, may decrease the effect of aprepitant.
Betamethasone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, betamethasone.
Capecitabine Capecitabine increases the effect of hydantoin
Chloramphenicol Increases phenytoin, modifies chloramphenicol
Chlordiazepoxide Mephenytoin may increase the metabolism of chlordiazepoxide via CYP3A4.
Chlorpheniramine The antihistamine increases the effect of hydantoin
Cimetidine Increases the effect of hydantoin
Ciprofloxacin Decreases the hydantoin effect
Clomifene The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, clomifene.
Clorazepate Mephenytoin may increase the metabolism of clorazepate via CYP3A4.
Clozapine Hydantoin decreases the effect of clozapine
Conjugated Estrogens The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Cyclosporine The hydantoin decreases the effect of cyclosporine
Dexamethasone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, dexamethasone.
Diazepam Mephenytoin may increase the metabolism of diazepam via CYP3A4.
Diethylstilbestrol The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, diethylstilbestrol.
Disopyramide The hydantoin decreases the effect of disopyramide
Disulfiram Increases the effect of phenytoin
Doxycycline The anticonvulsant, mephenytoin, decreases the effect of doxycycline.
Estradiol The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, estradiol.
Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
Felbamate Increased phenytoin levels and decreased felbamate levels
Felodipine The hydantoin decreases the effect of felodipine
Fluconazole Increases the effect of hydantoin
Fludrocortisone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Fluorouracil Fluorouracil increases the effect of hydantoin
Fluoxetine Fluoxetine increases the effect of phenytoin
Flurazepam Mephenytoin may increase the metabolism of flurazepam via CYP3A4.
Fluvoxamine Increases the effect of hydantoin
Folic Acid Folic acid decreases the levels of hydantoin
Furosemide The hydantoin decreases the effect of furosemide
Gabapentin Increases the effect of hydantoin
Gefitinib The CYP3A4 inducer, mephenytoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Hydrocortisone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, hydrocortisone.
Imatinib The hydantoin decreases the levels of imatinib
Isoniazid Isoniazid increases the effect of phenytoin in 20% of patients
Itraconazole Phenytoin decreases the effect of itraconazole
Lamotrigine Phenytoin may reduce levels of lamotrigine
Levonorgestrel Phenytoin decreases the contraceptive effect
Mebendazole The hydantoin decreases the efficiency of mebendazole
Medroxyprogesterone The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, medroxyprogesterone.
Megestrol The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, megestrol.
Methadone The hydantoin decreases the effect of methadone
Methotrexate The antineoplasic agent decreases the effect of hydantoin
Methoxsalen The hydantoin decreases the effect of psoralene
Mexiletine The hydantoin decreases the effect of mexiletine
Midazolam Mephenytoin may increase the metabolism of midazolam via CYP3A4.
Mirtazapine The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Norethindrone This product may cause a slight decrease of contraceptive effect
Omeprazole Omeprazole increases the effect of hydantoin
Oxcarbazepine Oxcarbazepine increases the effect of hydantoin
Oxtriphylline Decreased effect of both products
Oxyphenbutazone The NSAID, oxyphenbutazone, may increase the hydantoin effect of mephenytoin.
Phenylbutazone The NSAID, phenylbutazone, may increase the hydantoin effect of mephenytoin.
Prednisolone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, prednisolone.
Prednisone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, prednisone.
Quetiapine Phenytoin decreases the effect of quetiapine
Rifampin Rifampin decreases the effect of the hydantoin
Theophylline Decreased effect of both products
Ticlopidine Ticlopidine increases the effect of hydantoin
Triamcinolone The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, triamcinolone.
Triazolam Mephenytoin may increase the metabolism of triazolam via CYP3A4.
Food Interactions Not Available

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Lenkowski PW, Ko SH, Anderson JD, Brown ML, Patel MK: Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin. Eur J Pharm Sci. 2004 Apr;21(5):635-44. - Pubmed
  • Swadron SP, Rudis MI, Azimian K, Beringer P, Fort D, Orlinsky M: A comparison of phenytoin-loading techniques in the emergency department. Acad Emerg Med. 2004 Mar;11(3):244-52. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4982

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Zhang T, Zhu Y, Gunaratna C: Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 25;780(2):371-9. - Pubmed
DTHybrid score 0.4453
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Pivi Taavitsainen. (2000). Cytochrome P450 isoform-specific in vitro methods to predict drug metabolism and interactions. Department of Pharmacology and Toxicology, University of Oulu. - Source
  • Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. - Pubmed
  • Heyn H, White RB, Stevens JC: Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. Drug Metab Dispos. 1996 Sep;24(9):948-54. - Pubmed
DTHybrid score 0.3342
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Coller JK, Somogyi AA, Bochner F: Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol. 1999 Aug;48(2):158-67. - Pubmed
  • Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. - Pubmed
DTHybrid score 0.4415
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. - Pubmed
DTHybrid score 0.5109
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3573
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.515

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.4479
1588 Multidrug resistance protein 1 ABCB1 0.2069
4118 Cytochrome P450 3A5 CYP3A5 0.1828
6013 Cytochrome P450 2E1 CYP2E1 0.1635
6107 Cytochrome P450 3A7 CYP3A7 0.1358
6024 Cytochrome P450 1A1 CYP1A1 0.1254
5718 Cytochrome P450 2A6 CYP2A6 0.1138
587 Serum albumin ALB 0.108
20 Prostaglandin G/H synthase 1 PTGS1 0.0973
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0798
6106 Cytochrome P450 2C18 CYP2C18 0.0759
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0747
492 Histamine H1 receptor HRH1 0.0712
824 Sodium-dependent serotonin transporter SLC6A4 0.0663
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0591
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0581
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0558
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0526
290 Prostaglandin G/H synthase 2 PTGS2 0.0481
502 5-hydroxytryptamine 2A receptor HTR2A 0.0477
6145 Solute carrier family 22 member 1 SLC22A1 0.0466
465 Calmodulin CALM1 0.046
831 D(2) dopamine receptor DRD2 0.0451
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0447
6144 Solute carrier family 22 member 2 SLC22A2 0.0441
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0429
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0427
713 Sodium-dependent dopamine transporter SLC6A3 0.0409
556 Alpha-1A adrenergic receptor ADRA1A 0.0409
1729 Solute carrier family 22 member 6 SLC22A6 0.0407
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0402
862 Multidrug resistance-associated protein 1 ABCC1 0.0398
3811 Cytochrome P450 19A1 CYP19A1 0.0386
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0379
1898 Cytochrome P450 1B1 CYP1B1 0.0371
118 Organic cation/carnitine transporter 2 SLC22A5 0.037
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0362
3941 Amine oxidase [flavin-containing] A MAOA 0.034
766 Beta-2 adrenergic receptor ADRB2 0.0337
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0333
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0332
318 Alpha-2A adrenergic receptor ADRA2A 0.0327
617 Muscarinic acetylcholine receptor M2 CHRM2 0.032
590 5-hydroxytryptamine 2C receptor HTR2C 0.0318
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0303
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.03
193 Beta-1 adrenergic receptor ADRB1 0.029
23 D(1A) dopamine receptor DRD1 0.0285
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0279
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0276
776 Bile salt export pump ABCB11 0.0272
731 HIV-1 protease HIV-1 protease 0.027
3923 Cholinesterase BCHE 0.0269
341 5-hydroxytryptamine 3 receptor HTR3A 0.0266
847 Mu-type opioid receptor OPRM1 0.0264
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0262
632 Alpha-1B adrenergic receptor ADRA1B 0.026
2164 Multidrug resistance-associated protein 4 ABCC4 0.026
36 Insulin receptor INSR 0.0258
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0258
136 Estrogen receptor ESR1 0.0256
3939 Amine oxidase [flavin-containing] B MAOB 0.0256
6142 Solute carrier family 22 member 8 SLC22A8 0.0253
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0251
320 5-hydroxytryptamine 1A receptor HTR1A 0.0247
833 Organic cation/carnitine transporter 1 SLC22A4 0.0245
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.024
696 Kappa-type opioid receptor OPRK1 0.0234
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0233
468 Cytochrome P450 4A11 CYP4A11 0.0229
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0228
467 Delta-type opioid receptor OPRD1 0.0228
260 Cytochrome P450 51 ERG11 0.0227
761 Cytochrome P450 51 ERG11 0.0227
3163 Cytochrome P450 51 cyp51 0.0227
6147 Solute carrier family 22 member 3 SLC22A3 0.0225
6220 Aryl hydrocarbon receptor AHR 0.0222
122 P2Y purinoceptor 12 P2RY12 0.0221
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0217
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0214
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0211
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0207
6143 Solute carrier family 22 member 7 SLC22A7 0.0206
891 Dihydropteroate synthase folP 0.02
5359 Dihydropteroate synthase folP 0.02
7175 Dihydropteroate synthase sulI 0.02
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0199
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0199
885 5-hydroxytryptamine 1B receptor HTR1B 0.0197
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0196
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0194
817 DNA topoisomerase 2-alpha TOP2A 0.0192
638 D(3) dopamine receptor DRD3 0.0187
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0178
146 Androgen receptor AR 0.0175
6031 Cytochrome P450 3A43 CYP3A43 0.0174
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0174
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0174
172 Potassium channel subfamily K member 1 KCNK1 0.0174
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0166
789 Alpha-1D adrenergic receptor ADRA1D 0.0163
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.016
725 5-hydroxytryptamine 1D receptor HTR1D 0.0159
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0159
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0159
921 Glutamate receptor 2 GRIA2 0.0158
6182 Cytochrome P450 2J2 CYP2J2 0.0156
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0155
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0152
629 Alpha-2B adrenergic receptor ADRA2B 0.0151
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.015
70 Type-1 angiotensin II receptor AGTR1 0.0148
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0148
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0144
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0144
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0143
844 Epidermal growth factor receptor EGFR 0.0141
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0134
504 Mast/stem cell growth factor receptor KIT 0.0134
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0133
432 D(4) dopamine receptor DRD4 0.013
1024 Solute carrier family 22 member 11 SLC22A11 0.0129
33 Cystine/glutamate transporter SLC7A11 0.0127
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
6136 Multidrug resistance-associated protein 5 ABCC5 0.0126
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
4120 NADPH--cytochrome P450 reductase POR 0.0125
94 5-hydroxytryptamine 4 receptor HTR4 0.0124
436 5-hydroxytryptamine 2B receptor HTR2B 0.0121
380 Cytochrome P450 17A1 CYP17A1 0.0121
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0121
378 Alpha-2C adrenergic receptor ADRA2C 0.012
1757 Myeloperoxidase MPO 0.012
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0119
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0118
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0118
124 Histamine H2 receptor HRH2 0.0118
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0115
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0113
777 Tumor necrosis factor TNF 0.0113
174 Sigma 1-type opioid receptor SIGMAR1 0.0112
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0112
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0111
571 Melatonin receptor type 1A MTNR1A 0.011
362 Melatonin receptor type 1B MTNR1B 0.011
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0109
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0109
6102 Arylamine N-acetyltransferase 2 NAT2 0.0108
871 Glucocorticoid receptor NR3C1 0.0108
1010 Cytochrome P450 51A1 CYP51A1 0.0107
4604 Liver carboxylesterase 1 CES1 0.0106
6137 Multidrug resistance-associated protein 6 ABCC6 0.0105
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0105
6148 Multidrug resistance-associated protein 7 ABCC10 0.0105
811 Translocator protein TSPO 0.0104
1656 CYP2B protein CYP2B 0.0104
365 Dihydrofolate reductase DHFR 0.0104
2381 Dihydrofolate reductase DFR1 0.0104
2833 Dihydrofolate reductase Not Available 0.0104
2931 Dihydrofolate reductase folA 0.0104
3544 Dihydrofolate reductase folA 0.0104
3682 Dihydrofolate reductase folA 0.0104
6642 Dihydrofolate reductase folA 0.0104
6756 Dihydrofolate reductase dfrA 0.0104
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0104
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0104
6014 Cytochrome P450 2A13 CYP2A13 0.0103
482 Glycine receptor subunit alpha-1 GLRA1 0.0101
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0098
16 Adenosine A1 receptor ADORA1 0.0098
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0097
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0097
407 Vascular endothelial growth factor receptor 2 KDR 0.0097
869 Estrogen receptor beta ESR2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6141 Sodium/bile acid cotransporter SLC10A1 0.0097
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0096
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0096
26 Vascular endothelial growth factor receptor 3 FLT4 0.0096
427 Substance-P receptor TACR1 0.0096
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0094
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0094
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0094
1178 Adenosine A2a receptor ADORA2A 0.0094
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0094
32 Vascular endothelial growth factor receptor 1 FLT1 0.0092
163 D(1B) dopamine receptor DRD5 0.0091
716 5-hydroxytryptamine 7 receptor HTR7 0.0089
228 Beta platelet-derived growth factor receptor PDGFRB 0.0087
4116 Dihydropteroate synthetase Not Available 0.0087
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0086
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0085
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0084
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0084
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0084
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0084
756 Sex hormone-binding globulin SHBG 0.0084
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0084
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0084
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0084
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0083
295 Carbonic anhydrase 1 CA1 0.0082
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0082
373 Transthyretin TTR 0.0082
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0081
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0081
474 Acetylcholinesterase ACHE 0.008
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0079
6085 Fatty acid-binding protein, intestinal FABP2 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
592 Carbonic anhydrase 4 CA4 0.0077
161 Tubulin beta chain TUBB 0.0077
312 Tubulin beta chain TUB2 0.0077
818 50S ribosomal protein L10 rplJ 0.0076
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0075
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0075
131 Synaptic vesicular amine transporter SLC18A2 0.0074
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0072
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0071
4122 Histone deacetylase 2 HDAC2 0.0071
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0071
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
49 Endothelin B receptor EDNRB 0.007
275 Arachidonate 5-lipoxygenase ALOX5 0.007
6020 Aldehyde oxidase AOX1 0.007
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.007
3810 Catechol O-methyltransferase COMT 0.0069
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0068
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0068
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0068
537 ATP synthase delta chain, mitochondrial ATP5D 0.0067
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0067
3947 Xanthine dehydrogenase/oxidase XDH 0.0066
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0066
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0065
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0064
518 Peroxidase/catalase T katG 0.0064
6126 Carbonic anhydrase 7 CA7 0.0063
1618 High affinity nerve growth factor receptor NTRK1 0.0063
173 Toll-like receptor 7 TLR7 0.0063
133 Dihydropterate synthase sulI 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
614 Progesterone receptor PGR 0.0062
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0062
88 Retinoic acid receptor RXR-beta RXRB 0.0062
563 Thyroid peroxidase TPO 0.0062
738 Monocarboxylate transporter 1 SLC16A1 0.0062
823 Fibroblast growth factor receptor 2 FGFR2 0.0061
2112 Toll-like receptor 9 TLR9 0.0061
4203 Histamine N-methyltransferase HNMT 0.006
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.006
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.006
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.006
1541 Metalloproteinase mmp20 0.006
1256 5-hydroxytryptamine 6 receptor HTR6 0.006
273 Apoptosis regulator Bcl-2 BCL2 0.0059
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0059
183 Vascular endothelial growth factor A VEGFA 0.0058
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0058
5880 Thrombopoietin receptor MPL 0.0058
705 Glutamate receptor 1 GRIA1 0.0058
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0057
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0057
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0057
511 5-hydroxytryptamine 1F receptor HTR1F 0.0057
357 Carbonic anhydrase 2 CA2 0.0057
528 5-hydroxytryptamine 1E receptor HTR1E 0.0057
952 Dipeptidyl peptidase 4 DPP4 0.0056
751 Potassium channel subfamily K member 6 KCNK6 0.0056
29 Tubulin beta-1 chain TUBB1 0.0056
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0056
6432 Transporter snf 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
1648 Elastin ELN 0.0054
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0054
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0054
634 Squalene monooxygenase SQLE 0.0053
7196 Squalene monooxygenase ERG1 0.0053
6044 Serum paraoxonase/lactonase 3 PON3 0.0053
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0053
1629 Transcription factor AP-1 JUN 0.0053
24 Thymidylate synthase TMP1 0.0053
359 Thymidylate synthase TYMS 0.0053
2626 Thymidylate synthase thyA 0.0053
2729 Thymidylate synthase thyA 0.0053
5352 Thymidylate synthase THYA 0.0053
6146 High affinity copper uptake protein 1 SLC31A1 0.0052
1275 Estrogen sulfotransferase SULT1E1 0.0052
1192 Sulfotransferase 1A1 SULT1A1 0.0052
4311 tRNA TRDMT1 0.0051
4325 tRNA trmD 0.0051
4328 tRNA trmD 0.0051
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0051
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0051
581 Cytochrome P450 2R1 CYP2R1 0.0051
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.005
208 DNA-directed RNA polymerase beta' chain rpoC 0.0049
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0049
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0049
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0049
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0048
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0048
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0048
1992 Vitamin D-binding protein GC 0.0048
84 Nuclear receptor 0B1 NR0B1 0.0047
319 Opioid receptor, sigma 1 OPRS1 0.0047
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0047
737 Mineralocorticoid receptor NR3C2 0.0046
1050 Bile salt sulfotransferase SULT2A1 0.0046
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0046
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0046
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0046
1517 Beta-3 adrenergic receptor ADRB3 0.0046
162 Retinoic acid receptor gamma-1 RARG 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
5300 Antigen peptide transporter 1 TAP1 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0045
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0044
1630 Integrin beta-2 ITGB2 0.0044
780 Retinoic acid receptor RXR-gamma RXRG 0.0044
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0044
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0042
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0041
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
165 FL cytokine receptor FLT3 0.0041
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
3932 Glutathione S-transferase A2 GSTA2 0.004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0039
7 Nitric oxide synthase, inducible NOS2 0.0039
976 Platelet glycoprotein IX GP9 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0039
4103 Proteasome subunit beta type 2 PSMB2 0.0039
4102 Proteasome subunit beta type 5 PSMB5 0.0039
4101 Proteasome subunit beta type 1 PSMB1 0.0039
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0039
6174 50S ribosomal protein L32 rpmF 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
1262 Corticotropin-lipotropin POMC 0.0038
284 DNA-directed RNA polymerase beta chain rpoB 0.0038
5773 DNA-directed RNA polymerase beta chain rpoB 0.0038
904 Glutathione S-transferase P GSTP1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1196 Complement decay-accelerating factor CD55 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
130 Prostacyclin synthase PTGIS 0.0037
3809 Estrogen-related receptor gamma ESRRG 0.0037
2539 Tubulin alpha-1 chain TUBA4A 0.0036
3086 Plasmepsin-2 Not Available 0.0036
2981 Phospholipase A2, membrane associated PLA2G2A 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
3957 Adenosine deaminase ADA 0.0036
856 Vitamin D3 receptor VDR 0.0036
153 Dopamine beta-hydroxylase DBH 0.0035
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0035
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0035
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
5934 Cytochrome P450 26A1 CYP26A1 0.0035
469 Annexin A1 ANXA1 0.0035
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0034
712 Tubulin alpha chain TUB1 0.0034
239 Coagulation factor X F10 0.0033
6506 Stathmin-4 STMN4 0.0033
2808 Chloramphenicol acetyltransferase 3 cat3 0.0033
229 Retinoic acid receptor beta RARB 0.0033
5787 Angiopoietin-1 receptor TEK 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0032
251 Alcohol dehydrogenase 1A ADH1A 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
164 Histamine H4 receptor HRH4 0.0032
3937 Fatty-acid amide hydrolase FAAH 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
3808 Dihydropteroate synthase 2 folP2 0.003
3601 Dihydropteroate synthase 1 folP1 0.003
3807 Dihydropteroate synthase 1 folP1 0.003
820 Glycine receptor subunit alpha-2 GLRA2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
2417 Chloramphenicol acetyltransferase cat 0.003
3278 Chloramphenicol acetyltransferase cat 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.003
2810 Dr hemagglutinin structural subunit draA 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.003
1039 Histone deacetylase 9 HDAC9 0.003
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0029
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0029
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0029
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0029
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0029
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0029
54 Prothrombin F2 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0029
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0029
814 Ryanodine receptor 1 RYR1 0.0029
5798 Mitogen-activated protein kinase 11 MAPK11 0.0029
444 Alcohol dehydrogenase 1B ADH1B 0.0029
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0028
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0028
6134 Sodium channel subunit beta-3 SCN3B 0.0028
6132 Sodium channel subunit beta-1 SCN1B 0.0028
6135 Sodium channel subunit beta-4 SCN4B 0.0028
6133 Sodium channel subunit beta-2 SCN2B 0.0028
6127 Carbonic anhydrase-related protein CA8 0.0028
6129 Carbonic anhydrase-related protein 11 CA11 0.0028
6128 Carbonic anhydrase-related protein 10 CA10 0.0028
267 Plasminogen activator inhibitor 1 SERPINE1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
2159 Quinone oxidoreductase CRYZ 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0026
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0026
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0026
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0026
6221 Steroid hormone receptor ERR1 ESRRA 0.0026
268 Adenosine A2b receptor ADORA2B 0.0025
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
85 Growth hormone receptor GHR 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0025
719 Retinoic acid receptor responder protein 1 RARRES1 0.0025
770 Retinoic acid-induced protein 3 GPRC5A 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0025
517 Alcohol dehydrogenase 1C ADH1C 0.0025
6130 Carbonic anhydrase 13 CA13 0.0024
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0024
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
572 Integrin alpha-L ITGAL 0.0024
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0024
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0024
6070 Nischarin NISCH 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
291 Nitric-oxide synthase, endothelial NOS3 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
68 Cannabinoid receptor 1 CNR1 0.0022
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
1360 Sphingomyelin phosphodiesterase SMPD1 0.0022
569 Retinal dehydrogenase 2 ALDH1A2 0.0022
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0022
6122 Carbonic anhydrase 3 CA3 0.0022
1864 RET proto-oncogene RET 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
611 Retinal dehydrogenase 1 ALDH1A1 0.0021
1374 Natriuretic peptides B NPPB 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3913 Glutamic acid decarboxylase GAD65 0.0021
1827 Gap junction alpha-1 protein GJA1 0.0021
1908 Vascular cell adhesion protein 1 VCAM1 0.0021
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
2021 Thrombomodulin THBD 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
3007 Carbonic anhydrase 12 CA12 0.002
4205 Carbonic anhydrase 9 CA9 0.002
2207 Rhodopsin RHO 0.002
6048 Troponin C, skeletal muscle TNNC2 0.002
1820 Beta-nerve growth factor NGF 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
6043 Putative G-protein coupled receptor 44 GPR44 0.0019
2449 Tubulin alpha-3 chain TUBA1A 0.0019
1483 Membrane copper amine oxidase AOC3 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0018
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
1253 Interferon gamma IFNG 0.0018
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0018
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0018
1268 Neuropeptide S receptor NPSR1 0.0018
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0018
1341 Histamine H3 receptor HRH3 0.0018
4192 DNA topoisomerase 2-beta TOP2B 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
735 Alanine aminotransferase 1 GPT 0.0017
3904 Alanine aminotransferase 2 GPT2 0.0017
828 Phenylalanine-4-hydroxylase PAH 0.0017
3109 Phenylalanine-4-hydroxylase phhA 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6218 Pannexin-1 PANX1 0.0017
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0017
6073 Potassium channel subfamily K member 9 KCNK9 0.0017
6072 Potassium channel subfamily K member 3 KCNK3 0.0017
1830 5'-nucleotidase NT5E 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
489 Monocarboxylate transporter 2 SLC16A7 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
760 Fibroblast growth factor 1 FGF1 0.0016
1243 Cathepsin D CTSD 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0015
758 Thyroid hormone receptor alpha THRA 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4773 Deoxycytidine kinase DCK 0.0014
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
3404 Exotoxin A eta 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
6824 Tyrosine-protein kinase Lyn LYN 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
4948 Cytochrome c-553 Not Available 0.0011
4923 Cytochrome c3 DvMF_2499 0.0011
4945 Cytochrome c3 Not Available 0.0011
4949 Cytochrome c3 DVU_3171 0.0011
4968 Cytochrome c3 cytc3 0.0011
4997 Cytochrome c3 SO_2727 0.0011
5219 Cytochrome c3 cyd 0.0011
4902 Nine-heme cytochrome c Ddes_2038 0.0011
3189 High-molecular-weight cytochrome c hmcA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0011
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0011
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0011
6168 Solute carrier family 22 member 16 SLC22A16 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1353 DNA topoisomerase 1 TOP1 0.001
3552 DNA topoisomerase 1 topA 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
3221 Cytochrome c4 cc4 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
1507 Cytochrome c CYCS 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
822 Aldose reductase AKR1B1 0.0007
4954 Soluble cytochrome b558 Not Available 0.0007
4925 Cytochrome c-type protein SHP shp 0.0007
4916 Cyanoglobin glbN 0.0007
4947 Bacterial hemoglobin vhb 0.0007
4915 Cytochrome c-550 psbV 0.0007
4959 Cytochrome c-550 psbV 0.0007
5216 Cytochrome c-550 psbV 0.0007
4934 Cytochrome c-551 nirM 0.0007
5218 Cytochrome c-551 nirM 0.0007
4975 Cytochrome c-556 RPA3973 0.0007
4943 Cytochrome c6 petJ 0.0007
4994 Hemoglobin-like protein HbO glbO 0.0007
4905 Cytochrome c2 Not Available 0.0007
4939 Cytochrome c2 cycA 0.0007
4964 Cytochrome c2 cycA 0.0007
4979 Cytochrome c2 cycA 0.0007
6673 Cytochrome c2 cycA 0.0007
4936 Cytochrome c2 iso-2 Not Available 0.0007
4984 Neuroglobin NGB 0.0007
4998 Hemoglobin-like protein yjbI yjbI 0.0007
5000 HemO hemO 0.0007
3116 Bacterioferritin bfr 0.0007
4906 Bacterioferritin bfr 0.0007
4965 Bacterioferritin bfr 0.0007
4909 CooA protein cooA 0.0007
4910 Cytoglobin CYGB 0.0007
4907 Cytochrome c-L moxG 0.0007
6865 Cytochrome c-L moxG 0.0007
4981 Iron-starvation protein PigA pigA 0.0007
644 Heme oxygenase 2 HMOX2 0.0007
4982 Heme oxygenase 2 pbsA2 0.0007
4942 Diheme cytochrome c napB napB 0.0007
4961 Hemophore HasA hasA 0.0007
4935 Cytochrome c-554 cycA1 0.0007
4971 Nonaheme cytochrome c hmcA 0.0007
4904 Cytochrome c family protein GSU1996 0.0007
4976 Apocytochrome f petA 0.0007
6407 Apocytochrome f petA 0.0007
4999 Cytochrome P450 165B3 CYP165B3 0.0007
4764 Cytochrome P450 165C4 CYP165C4 0.0007
4937 Cytochrome oxidase subunit II rcoxA 0.0007
4960 Putative cytochrome P450-family protein SCO7417 0.0007
4931 Cytochrome P450 167A1 CYP167A1 0.0007
4989 Cytochrome c551 peroxidase ccp 0.0007
5222 Cytochrome c551 peroxidase ccpA 0.0007
4903 Methyl-accepting chemotaxis protein Tar4 0.0007
4922 Cytochrome c, putative SO_4144 0.0007
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0007
4926 Heme-based aerotactic transducer hemAT hemAT 0.0007
4972 P450cin cinA 0.0007
4993 Hydroxylamine oxidoreductase hao1 0.0007
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0007
3093 Catalase HPII katE 0.0007
4952 Catalase/peroxidase katA 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4920 Peroxidase/catalase katG 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
798 Osteocalcin BGLAP 0.0005
2230 Catalase CAT 0.0005
3249 Catalase katA 0.0005
3625 Catalase katA 0.0005
4539 Catalase katA 0.0005
4941 Catalase katB 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
2298 Cytochrome P450-cam camC 0.0003
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