DT-Web: DB00286

Identification

Name

Conjugated Estrogens

Accession Number

DB00286 (APRD00396)

Type

small molecule

Description

Conjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 ?-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Estrogens

Molecular Weight

372.411

Groups

approved

Monoisotopic Weight

372.100739147

Pharmacology

Indication

For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)

Mechanism of action

Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary.

Absorption

Well absorbed

Protein binding

90% bound to plasma proteins

Biotransformation

Hepatic

Route of elimination

Estradiol, estrone, and estriol are excreted in the urine, along with glucuronide and sulfate conjugates. Exogenous estrogens are metabolized in the same manner as endogenous estrogens.

Toxicity

Nausea and vomiting

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amobarbital	The enzyme inducer, amobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Aprobarbital	The enzyme inducer, aprobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Butabarbital	The enzyme inducer, butabarbital, decreases the effect of the hormone agent, conjugated estrogens.
Butalbital	The enzyme inducer, butalbital, decreases the effect of the hormone agent, conjugated estrogens.
Butethal	The enzyme inducer, butethal, decreases the effect of the hormone agent, conjugated estrogens.
Ethotoin	The enzyme inducer, ethotoin, decreases the effect of the hormone agent, conjugated estrogens.
Fosphenytoin	The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Griseofulvin	The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, conjugated estrogens.
Heptabarbital	The enzyme inducer, heptabarbital, decreases the effect of the hormone agent, conjugated estrogens.
Hexobarbital	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Mephenytoin	The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Methohexital	The enzyme inducer, methohexital, decreases the effect of the hormone agent, conjugated estrogens.
Methylphenobarbital	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Pentobarbital	The enzyme inducer, pentobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Phenobarbital	The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Phenytoin	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Prednisolone	The estrogenic agent may increase the effect of the corticosteroid, prednisolone.
Prednisone	The estrogenic agent may increase the effect of corticosteroid, prednisone.
Primidone	The enzyme inducer, primidone, decreases the effect of the hormone agent, conjugated estrogens.
Raloxifene	Association not recommended
Secobarbital	The enzyme inducer, secobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Talbutal	The enzyme inducer, talbutal, decreases the effect of the hormone agent, conjugated estrogens.
Tipranavir	Conjugated estrogens may increase the adverse dermatological effects (i.e. skin rash) of Tipranavir. Tipranavir may decrease the serum concentration Conjugated estrogens. Monitor for estrogen deficiency during concomitant therapy.
Ursodeoxycholic acid	Estrogens decreases the effect of ursodiol

Food Interactions

Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.
Take with food to reduce nausea.

Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	yes
Actions	agonist
References	Ropero AB, Eghbali M, Minosyan TY, Tang G, Toro L, Stefani E: Heart estrogen receptor alpha: distinct membrane and nuclear distribution patterns and regulation by estrogen. J Mol Cell Cardiol. 2006 Sep;41(3):496-510. Epub 2006 Jul 28. - Pubmed Stroud FC, Appt SE, Wilson ME, Franke AA, Adams MR, Kaplan JR: Concentrations of isoflavones in macaques consuming standard laboratory monkey diet. J Am Assoc Lab Anim Sci. 2006 Jul;45(4):20-3. - Pubmed Hou NN, Zhu YM, Huang HF: [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism] Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Aug;39(4):289-96. - Pubmed Gouva L, Tsatsoulis A: The role of estrogens in cardiovascular disease in the aftermath of clinical trials. Hormones (Athens). 2004 Jul-Sep;3(3):171-83. - Pubmed Smith MR: Selective estrogen receptor modulators to prevent treatment-related osteoporosis. Rev Urol. 2005;7 Suppl 3:S30-5. - Pubmed
DTHybrid score	0.808

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. - Pubmed
DTHybrid score	0.7776
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. - Pubmed
DTHybrid score	0.4762
Catechol O-methyltransferase
Name	Catechol O-methyltransferase
Gene Name	COMT
Actions	substrate
References	Zhu BT, Wu KY, Wang P, Cai MX, Conney AH: O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Inter-individual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols. Drug Metab Dispos. 2010 Jul 6. - Pubmed Jobe SO, Ramadoss J, Koch JM, Jiang Y, Zheng J, Magness RR: Estradiol-17beta and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension. 2010 Apr;55(4):1005-11. Epub 2010 Mar 8. - Pubmed
DTHybrid score	0.8421

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Hirohashi T, Suzuki H, Sugiyama Y: Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J Biol Chem. 1999 May 21;274(21):15181-5. - Pubmed
DTHybrid score	0.365
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Zelcer N, Reid G, Wielinga P, Kuil A, van der Heijden I, Schuetz JD, Borst P: Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. - Pubmed
DTHybrid score	0.4911
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Qian YM, Song WC, Cui H, Cole SP, Deeley RG: Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. J Biol Chem. 2001 Mar 2;276(9):6404-11. Epub 2000 Dec 1. - Pubmed
DTHybrid score	0.4673
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate,inhibitor
References	Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ: Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther. 2000 Jul;294(1):73-9. - Pubmed Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G: Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 1998 Mar 13;424(3):173-6. - Pubmed Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. - Pubmed Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed Kontaxi M, Echkardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E: Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J Pharmacol Exp Ther. 1996 Dec;279(3):1507-13. - Pubmed Pang KS, Wang PJ, Chung AY, Wolkoff AW: The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6. - Pubmed Bossuyt X, Muller M, Meier PJ: Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol. 1996 Nov;25(5):733-8. - Pubmed Hagenbuch B, Adler ID, Schmid TE: Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20. - Pubmed Lee TK, Koh AS, Cui Z, Pierce RH, Ballatori N: N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G371-81. Epub 2003 Apr 17. - Pubmed Kouzuki H, Suzuki H, Ito K, Ohashi R, Sugiyama Y: Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther. 1999 Feb;288(2):627-34. - Pubmed Eckhardt U, Schroeder A, Stieger B, Hochli M, Landmann L, Tynes R, Meier PJ, Hagenbuch B: Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am J Physiol. 1999 Apr;276(4 Pt 1):G1037-42. - Pubmed
DTHybrid score	0.6462
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	inhibitor
References	Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. - Pubmed
DTHybrid score	0.3749
Solute carrier family 22 member 10
Name	Solute carrier family 22 member 10
Gene Name	SLC22A10
Actions	inhibitor
References	Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol. 2004 Aug;287(2):F236-44. Epub 2004 Apr 6. - Pubmed
DTHybrid score	0.2012
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate,inhibitor
References	Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. - Pubmed Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK: Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43. Epub 2002 May 13. - Pubmed Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score	0.705
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	substrate,inhibitor
References	Tohyama K, Kusuhara H, Sugiyama Y: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91. Epub 2004 May 27. - Pubmed Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score	0.4296
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate,inhibitor
References	Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A: Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res. 2001 Sep;18(9):1262-9. - Pubmed Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. - Pubmed Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed Hirano M, Maeda K, Shitara Y, Sugiyama Y: Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46. Epub 2004 May 24. - Pubmed Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos. 2004 Mar;32(3):291-4. - Pubmed Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed van Montfoort JE, Schmid TE, Adler ID, Meier PJ, Hagenbuch B: Functional characterization of the mouse organic-anion-transporting polypeptide 2. Biochim Biophys Acta. 2002 Aug 19;1564(1):183-8. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.7025
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate
References	Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A: Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res. 2001 Sep;18(9):1262-9. - Pubmed Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. - Pubmed Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. - Pubmed Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. - Pubmed
DTHybrid score	0.5374
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score	0.813
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	substrate
References	Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK: Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43. Epub 2002 May 13. - Pubmed
DTHybrid score	0.7145
Organic solute transporter subunit alpha
Name	Organic solute transporter subunit alpha
Gene Name	OSTA
Actions	substrate
References	Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score	0.2934
Organic solute transporter subunit beta
Name	Organic solute transporter subunit beta
Gene Name	OSTB
Actions	substrate
References	Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score	0.2936
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Spears KJ, Ross J, Stenhouse A, Ward CJ, Goh LB, Wolf CR, Morgan P, Ayrton A, Friedberg TH: Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2. Biochem Pharmacol. 2005 Feb 1;69(3):415-23. Epub 2004 Dec 22. - Pubmed Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed
DTHybrid score	0.562
Solute carrier organic anion transporter family member 4A1
Name	Solute carrier organic anion transporter family member 4A1
Gene Name	SLCO4A1
Actions	substrate
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score	0.3932
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions	substrate
References	Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. - Pubmed
DTHybrid score	0.2824
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Hirano M, Maeda K, Shitara Y, Sugiyama Y: Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46. Epub 2004 May 24. - Pubmed Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos. 2004 Mar;32(3):291-4. - Pubmed
DTHybrid score	0.5294
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	substrate
References	Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score	0.4766
Solute carrier organic anion transporter family member 3A1
Name	Solute carrier organic anion transporter family member 3A1
Gene Name	SLCO3A1
Actions	substrate
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score	0.3453
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, Sugiyama Y: Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. Epub 2005 May 18. - Pubmed Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y: ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. Epub 2003 Apr 7. - Pubmed Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. - Pubmed
DTHybrid score	0.5208

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.4362
4924	Cytochrome P450 2C8	CYP2C8	0.3667
587	Serum albumin	ALB	0.332
6143	Solute carrier family 22 member 7	SLC22A7	0.3231
6016	Cytochrome P450 2C19	CYP2C19	0.3072
776	Bile salt export pump	ABCB11	0.2868
4118	Cytochrome P450 3A5	CYP3A5	0.2813
4119	Cytochrome P450 2D6	CYP2D6	0.2659
6241	Nuclear receptor coactivator 2	NCOA2	0.2359
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.221
6145	Solute carrier family 22 member 1	SLC22A1	0.2148
6107	Cytochrome P450 3A7	CYP3A7	0.1964
738	Monocarboxylate transporter 1	SLC16A1	0.1945
6136	Multidrug resistance-associated protein 5	ABCC5	0.1823
6030	Cytochrome P450 2B6	CYP2B6	0.1783
6024	Cytochrome P450 1A1	CYP1A1	0.1703
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.1647
6013	Cytochrome P450 2E1	CYP2E1	0.1635
6144	Solute carrier family 22 member 2	SLC22A2	0.1623
20	Prostaglandin G/H synthase 1	PTGS1	0.1608
118	Organic cation/carnitine transporter 2	SLC22A5	0.1546
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1526
6148	Multidrug resistance-associated protein 7	ABCC10	0.152
290	Prostaglandin G/H synthase 2	PTGS2	0.1504
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.131
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1242
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.1239
3587	Gastrotropin	FABP6	0.1219
869	Estrogen receptor beta	ESR2	0.1184
758	Thyroid hormone receptor alpha	THRA	0.1174
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1122
3811	Cytochrome P450 19A1	CYP19A1	0.1116
346	Thyroid hormone receptor beta-1	THRB	0.1006
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.1004
6137	Multidrug resistance-associated protein 6	ABCC6	0.0998
5718	Cytochrome P450 2A6	CYP2A6	0.0995
33	Cystine/glutamate transporter	SLC7A11	0.0962
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0958
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0921
1898	Cytochrome P450 1B1	CYP1B1	0.0919
594	Thyroxine-binding globulin	SERPINA7	0.0903
614	Progesterone receptor	PGR	0.0875
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0841
833	Organic cation/carnitine transporter 1	SLC22A4	0.0833
373	Transthyretin	TTR	0.0818
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0811
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0801
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0801
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0789
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0784
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.077
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0759
6147	Solute carrier family 22 member 3	SLC22A3	0.0732
817	DNA topoisomerase 2-alpha	TOP2A	0.0725
293	Gamma-glutamyl hydrolase	GGH	0.0661
1650	Heme carrier protein 1	SLC46A1	0.0625
70	Type-1 angiotensin II receptor	AGTR1	0.059
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0587
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0567
24	Thymidylate synthase	TMP1	0.0565
359	Thymidylate synthase	TYMS	0.0565
2626	Thymidylate synthase	thyA	0.0565
2729	Thymidylate synthase	thyA	0.0565
5352	Thymidylate synthase	THYA	0.0565
4604	Liver carboxylesterase 1	CES1	0.056
146	Androgen receptor	AR	0.0556
6106	Cytochrome P450 2C18	CYP2C18	0.0549
6218	Pannexin-1	PANX1	0.0541
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0538
3941	Amine oxidase [flavin-containing] A	MAOA	0.0527
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0527
5455	Arylsulfatase A	ARSA	0.0518
731	HIV-1 protease	HIV-1 protease	0.0507
756	Sex hormone-binding globulin	SHBG	0.05
318	Alpha-2A adrenergic receptor	ADRA2A	0.0487
404	DNA gyrase subunit A	gyrA	0.0486
6224	DNA gyrase subunit A	gyrA	0.0486
492	Histamine H1 receptor	HRH1	0.0483
275	Arachidonate 5-lipoxygenase	ALOX5	0.0483
527	Prostacyclin receptor	PTGIR	0.0479
199	Monocarboxylate transporter 8	SLC16A2	0.0472
871	Glucocorticoid receptor	NR3C1	0.0462
489	Monocarboxylate transporter 2	SLC16A7	0.0447
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0438
672	Prostaglandin F2-alpha receptor	PTGFR	0.0434
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0433
6085	Fatty acid-binding protein, intestinal	FABP2	0.0422
6151	Monocarboxylate transporter 10	SLC16A10	0.0421
477	DNA topoisomerase 4 subunit A	parC	0.0416
886	DNA topoisomerase 4 subunit A	parC	0.0416
6226	DNA topoisomerase 4 subunit A	parC	0.0416
6020	Aldehyde oxidase	AOX1	0.0414
5626	Nucleoside diphosphate kinase B	NME2	0.0404
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0402
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0393
193	Beta-1 adrenergic receptor	ADRB1	0.0391
3685	Catabolite gene activator	crp	0.0389
4655	Adenylate cyclase	cyaC	0.0389
4759	Adenylate cyclase	cyaB2	0.0389
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0384
718	Folate receptor gamma	FOLR3	0.0383
299	Folate receptor beta	FOLR2	0.0383
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0383
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0383
5818	Folate receptor alpha	FOLR1	0.0376
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0376
468	Cytochrome P450 4A11	CYP4A11	0.0373
140	30S ribosomal protein S9	rpsI	0.0368
6719	30S ribosomal protein S9	rpsI	0.0368
6725	30S ribosomal protein S9	rpsI	0.0368
22	30S ribosomal protein S4	rpsD	0.0365
6714	30S ribosomal protein S4	rpsD	0.0365
3939	Amine oxidase [flavin-containing] B	MAOB	0.0364
766	Beta-2 adrenergic receptor	ADRB2	0.0361
556	Alpha-1A adrenergic receptor	ADRA1A	0.0357
29	Tubulin beta-1 chain	TUBB1	0.0355
3947	Xanthine dehydrogenase/oxidase	XDH	0.0343
563	Thyroid peroxidase	TPO	0.0336
4760	Mll3241 protein	mll3241	0.0334
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0329
5294	Nucleoside diphosphate kinase A	NME1	0.0327
904	Glutathione S-transferase P	GSTP1	0.032
824	Sodium-dependent serotonin transporter	SLC6A4	0.0316
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0313
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0313
1792	Tissue-type plasminogen activator	PLAT	0.0312
273	Apoptosis regulator Bcl-2	BCL2	0.0312
633	Penicillin-binding proteins 1A/1B	pbpA	0.0297
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0295
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0293
6043	Putative G-protein coupled receptor 44	GPR44	0.0291
831	D(2) dopamine receptor	DRD2	0.029
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0282
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0281
645	Penicillin-binding protein 1A	mrcA	0.0277
5805	Penicillin-binding protein 1A	ponA	0.0277
6185	Penicillin-binding protein 1A	mrcA	0.0277
6799	Penicillin-binding protein 1A	pbpA	0.0277
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0273
3923	Cholinesterase	BCHE	0.0272
2539	Tubulin alpha-1 chain	TUBA4A	0.0271
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0269
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0269
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0267
558	Solute carrier family 12 member 1	SLC12A1	0.0267
1852	Microtubule-associated protein 2	MAP2	0.0264
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0263
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0262
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0262
36	Insulin receptor	INSR	0.0258
26	Vascular endothelial growth factor receptor 3	FLT4	0.0258
504	Mast/stem cell growth factor receptor	KIT	0.0258
3809	Estrogen-related receptor gamma	ESRRG	0.0257
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0256
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0255
6031	Cytochrome P450 3A43	CYP3A43	0.0254
887	DNA gyrase subunit B	gyrB	0.0252
4150	DNA gyrase subunit B	gyrB	0.0252
6225	DNA gyrase subunit B	gyrB	0.0252
6042	Prostaglandin reductase 2	PTGR2	0.0252
844	Epidermal growth factor receptor	EGFR	0.0252
543	Penicillin-binding protein 1B	mrcB	0.0249
6186	Penicillin-binding protein 1B	ponB	0.0249
6822	Penicillin-binding protein 1b	pbp1b	0.0249
6844	Penicillin-binding protein 1b	pbp1b	0.0249
1353	DNA topoisomerase 1	TOP1	0.0249
3552	DNA topoisomerase 1	topA	0.0249
438	Taste receptor type 1 member 2	TAS1R2	0.0248
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0248
32	Vascular endothelial growth factor receptor 1	FLT1	0.0247
117	Sterol O-acyltransferase 1	SOAT1	0.0245
380	Cytochrome P450 17A1	CYP17A1	0.0245
161	Tubulin beta chain	TUBB	0.0238
312	Tubulin beta chain	TUB2	0.0238
244	Angiotensin-converting enzyme	ACE	0.0237
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0235
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0235
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0232
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.023
6220	Aryl hydrocarbon receptor	AHR	0.0229
338	DNA polymerase	UL30	0.0228
379	DNA polymerase	UL54	0.0228
697	DNA polymerase	ORF28	0.0228
2482	DNA polymerase	43	0.0228
4104	DNA polymerase	BALF5	0.0228
365	Dihydrofolate reductase	DHFR	0.0227
2381	Dihydrofolate reductase	DFR1	0.0227
2833	Dihydrofolate reductase	Not Available	0.0227
2931	Dihydrofolate reductase	folA	0.0227
3544	Dihydrofolate reductase	folA	0.0227
3682	Dihydrofolate reductase	folA	0.0227
6642	Dihydrofolate reductase	folA	0.0227
6756	Dihydrofolate reductase	dfrA	0.0227
1313	Lactoylglutathione lyase	GLO1	0.0227
908	Glutathione S-transferase theta-1	GSTT1	0.0225
407	Vascular endothelial growth factor receptor 2	KDR	0.0223
23	D(1A) dopamine receptor	DRD1	0.0223
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0223
952	Dipeptidyl peptidase 4	DPP4	0.0223
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0223
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0222
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0221
737	Mineralocorticoid receptor	NR3C2	0.022
1757	Myeloperoxidase	MPO	0.021
357	Carbonic anhydrase 2	CA2	0.0208
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0206
4773	Deoxycytidine kinase	DCK	0.0205
5923	Microtubule-associated protein tau	MAPT	0.0198
5924	Microtubule-associated protein 4	MAP4	0.0198
53	Solute carrier family 12 member 5	SLC12A5	0.0197
663	Solute carrier family 12 member 4	SLC12A4	0.0197
2016	Dipeptidase 1	DPEP1	0.0197
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0192
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0192
847	Mu-type opioid receptor	OPRM1	0.0191
592	Carbonic anhydrase 4	CA4	0.0191
4120	NADPH--cytochrome P450 reductase	POR	0.0189
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0189
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0189
632	Alpha-1B adrenergic receptor	ADRA1B	0.0188
124	Histamine H2 receptor	HRH2	0.0188
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0188
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0188
6033	High affinity interleukin-8 receptor A	CXCR1	0.0187
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0187
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0185
310	Solute carrier family 12 member 2	SLC12A2	0.0184
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0184
295	Carbonic anhydrase 1	CA1	0.0183
260	Cytochrome P450 51	ERG11	0.0183
761	Cytochrome P450 51	ERG11	0.0183
3163	Cytochrome P450 51	cyp51	0.0183
5353	Glutamate decarboxylase alpha	gadA	0.0183
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0183
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0182
103	Muscarinic acetylcholine receptor M1	CHRM1	0.018
723	Cytosolic phospholipase A2	PLA2G4A	0.018
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0179
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0179
6228	Nuclear receptor coactivator 1	NCOA1	0.0176
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0176
2391	Ferrochelatase	hemH	0.0175
6502	Ferrochelatase	DKFZp686P18130	0.0175
1591	Ferrochelatase, mitochondrial	FECH	0.0175
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0175
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0175
1405	Thiopurine S-methyltransferase	TPMT	0.0174
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0174
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0173
3639	Thymidine phosphorylase	deoA	0.0173
3936	Thymidine phosphorylase	TYMP	0.0173
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0172
467	Delta-type opioid receptor	OPRD1	0.0172
992	Protein tyrosine kinase 2 beta	PTK2B	0.0171
890	Niemann-Pick C1-like protein 1	NPC1L1	0.017
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.017
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.017
713	Sodium-dependent dopamine transporter	SLC6A3	0.0169
115	Penicillin-binding protein 2	mrdA	0.0169
6069	Penicillin-binding protein 2	mrdA	0.0169
6118	Penicillin-binding protein 2	penA	0.0169
6187	Penicillin-binding protein 2	pbpA	0.0169
6686	Penicillin-binding protein 2	pbp2	0.0169
6939	Penicillin-binding protein 2	mrdA	0.0169
7163	Penicillin-binding protein 2	pbpA	0.0169
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0165
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0164
465	Calmodulin	CALM1	0.0163
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0162
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0161
284	DNA-directed RNA polymerase beta chain	rpoB	0.0161
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0161
789	Alpha-1D adrenergic receptor	ADRA1D	0.016
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.016
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0159
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
638	D(3) dopamine receptor	DRD3	0.0157
1	Peptidoglycan synthetase ftsI	ftsI	0.0157
4155	Peptidoglycan synthetase ftsI	ftsI	0.0157
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0157
2021	Thrombomodulin	THBD	0.0156
696	Kappa-type opioid receptor	OPRK1	0.0156
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
183	Vascular endothelial growth factor A	VEGFA	0.0153
1760	Aminopeptidase N	ANPEP	0.0152
6843	Aminopeptidase N	pepN	0.0152
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0151
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0151
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0151
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0151
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0151
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0151
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0151
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0151
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0151
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0151
6559	Cytochrome c oxidase subunit 2	ctaC	0.0151
6669	Cytochrome c oxidase subunit 2	ctaC	0.0151
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0151
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0151
6558	Cytochrome c oxidase subunit 1	ctaD	0.0151
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
330	Spermidine synthase	SRM	0.0149
3038	Spermidine synthase	speE	0.0149
1198	Serum paraoxonase/arylesterase 1	PON1	0.0149
6223	Penicillin-binding protein 1C	pbpC	0.0149
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0148
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0148
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0148
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0148
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0148
165	FL cytokine receptor	FLT3	0.0147
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0147
1867	Major prion protein	PRNP	0.0147
2320	Thymidine kinase, cytosolic	TK1	0.0147
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0147
4192	DNA topoisomerase 2-beta	TOP2B	0.0146
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6014	Cytochrome P450 2A13	CYP2A13	0.0144
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0144
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0142
702	UMP-CMP kinase	CMPK1	0.0142
4237	50S ribosomal protein L22	rplV	0.0139
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0139
2540	Choloylglycine hydrolase	cbh	0.0139
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0138
896	Glutathione S-transferase Mu 1	GSTM1	0.0137
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0137
629	Alpha-2B adrenergic receptor	ADRA2B	0.0136
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0135
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0134
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
185	Vasopressin V1a receptor	AVPR1A	0.0131
130	Prostacyclin synthase	PTGIS	0.0131
232	Corticosteroid-binding globulin	SERPINA6	0.0131
4238	50S ribosomal protein L4	rplD	0.0131
5578	50S ribosomal protein L4	rplD	0.0131
6173	50S ribosomal protein L4	rplD	0.0131
6219	50S ribosomal protein L4	rplD	0.0131
411	Glycine N-methyltransferase	GNMT	0.0131
450	Muscarinic acetylcholine receptor M4	CHRM4	0.013
3307	Acriflavine resistance protein B	acrB	0.013
6501	Fatty acid-binding protein, liver	FABP1	0.013
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.013
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
6146	High affinity copper uptake protein 1	SLC31A1	0.0128
6207	30S ribosomal protein S14	rpsN	0.0127
6209	30S ribosomal protein S19	rpsS	0.0127
6712	30S ribosomal protein S19	rpsS	0.0127
6726	30S ribosomal protein S19	rpsS	0.0127
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0127
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0127
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0126
4217	Telomerase reverse transcriptase	TERT	0.0126
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0126
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0126
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0125
6163	Copper-transporting ATPase 2	ATP7B	0.0122
6165	Copper-transporting ATPase 1	ATP7A	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
777	Tumor necrosis factor	TNF	0.0122
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0121
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.012
6182	Cytochrome P450 2J2	CYP2J2	0.012
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
358	Cystathionine beta-synthase	CBS	0.0118
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0117
432	D(4) dopamine receptor	DRD4	0.0117
1192	Sulfotransferase 1A1	SULT1A1	0.0116
6126	Carbonic anhydrase 7	CA7	0.0115
818	50S ribosomal protein L10	rplJ	0.0115
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0115
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0114
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0113
378	Alpha-2C adrenergic receptor	ADRA2C	0.0113
2249	Aspartate aminotransferase	aspC	0.0112
2671	Aspartate aminotransferase	aspC	0.0112
5490	Aspartate aminotransferase	Not Available	0.0112
6837	Serine/threonine-protein kinase 17B	STK17B	0.0112
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0112
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0112
6168	Solute carrier family 22 member 16	SLC22A16	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
2449	Tubulin alpha-3 chain	TUBA1A	0.0111
500	Monocarboxylate transporter 4	SLC16A3	0.0111
3426	Glutamine synthetase	glnA	0.011
3987	Glutamine synthetase	GLUL	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0109
2443	Azurin	azu	0.0108
6500	Phospholipase A2	PLA2G1B	0.0108
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0108
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0107
1629	Transcription factor AP-1	JUN	0.0106
2107	Microtubule-associated protein 1A	MAP1A	0.0106
5880	Thrombopoietin receptor	MPL	0.0106
5787	Angiopoietin-1 receptor	TEK	0.0106
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0105
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0103
517	Alcohol dehydrogenase 1C	ADH1C	0.0103
2599	Tyrosine-protein kinase HCK	HCK	0.0103
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0102
5482	Sialidase-2	NEU2	0.0101
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0101
571	Melatonin receptor type 1A	MTNR1A	0.0101
362	Melatonin receptor type 1B	MTNR1B	0.0101
469	Annexin A1	ANXA1	0.01
4226	Uridine phosphorylase 2	UPP2	0.0099
1648	Elastin	ELN	0.0098
5650	NimA-related protein	DR_0842	0.0098
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0098
4122	Histone deacetylase 2	HDAC2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0096
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0096
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0096
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0095
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0095
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0094
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0094
867	Penicillin-binding protein 3	pbpC	0.0094
6119	Penicillin-binding protein 3	pbp3	0.0094
7154	Penicillin-binding protein 3	pbp3	0.0094
7157	Penicillin-binding protein 3	LMHCC_2184	0.0094
7162	Penicillin-binding protein 3	pbpB	0.0094
7172	Penicillin-binding protein 3	pbp3	0.0094
6171	Solute carrier family 28 member 3	SLC28A3	0.0094
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0094
381	Prolactin receptor	PRLR	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
3932	Glutathione S-transferase A2	GSTA2	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
163	D(1B) dopamine receptor	DRD5	0.0092
65	Matrix metalloproteinase-9	Not Available	0.0092
1654	Interleukin-1 beta	IL1B	0.0092
6044	Serum paraoxonase/lactonase 3	PON3	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.009
4225	Uridine phosphorylase 1	UPP1	0.009
122	P2Y purinoceptor 12	P2RY12	0.009
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0089
474	Acetylcholinesterase	ACHE	0.0089
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0088
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0086
3856	Fibroblast growth factor receptor 3	FGFR3	0.0086
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0086
413	Amidophosphoribosyltransferase	PPAT	0.0085
2515	Amidophosphoribosyltransferase	purF	0.0085
3714	Amidophosphoribosyltransferase	purF	0.0085
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0085
2808	Chloramphenicol acetyltransferase 3	cat3	0.0085
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0083
1517	Beta-3 adrenergic receptor	ADRB3	0.0083
16	Adenosine A1 receptor	ADORA1	0.0083
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0083
4210	Toll-like receptor 4	TLR4	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
3957	Adenosine deaminase	ADA	0.0081
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0081
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0081
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0081
1291	cAMP response element-binding protein	CREB1	0.008
6138	Multidrug resistance protein 3	ABCB4	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0079
1630	Integrin beta-2	ITGB2	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
1178	Adenosine A2a receptor	ADORA2A	0.0079
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
1050	Bile salt sulfotransferase	SULT2A1	0.0077
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0077
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0076
494	Caspase-1	CASP1	0.0075
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0075
2298	Cytochrome P450-cam	camC	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
714	Glutathione reductase, mitochondrial	GSR	0.0072
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0072
1507	Cytochrome c	CYCS	0.0071
68	Cannabinoid receptor 1	CNR1	0.0071
7	Nitric oxide synthase, inducible	NOS2	0.0071
6131	Carbonic anhydrase 14	CA14	0.0071
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0071
768	FK506-binding protein 1A	FKBP1A	0.007
716	5-hydroxytryptamine 7 receptor	HTR7	0.007
6210	Tubulin delta chain	TUBD1	0.0069
6211	Tubulin epsilon chain	TUBE1	0.0069
6212	Tubulin gamma-1 chain	TUBG1	0.0069
3760	Penicillin-binding protein 5 precursor	dacA	0.0068
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0068
3014	Ribonuclease UK114	HRSP12	0.0068
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0067
5428	Replication protein	repA	0.0067
3617	Non-heme chloroperoxidase	cpo	0.0067
5426	Non-heme chloroperoxidase	cpo	0.0067
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0067
3018	HTH-type transcriptional regulator malT	malT	0.0067
751	Potassium channel subfamily K member 6	KCNK6	0.0067
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0067
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0067
6122	Carbonic anhydrase 3	CA3	0.0066
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0066
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0066
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0065
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0065
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0065
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0064
1714	Mitogen-activated protein kinase 3	MAPK3	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
2077	Caspase-3	CASP3	0.0063
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0063
3270	Elongation factor G	fusA	0.0062
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
172	Potassium channel subfamily K member 1	KCNK1	0.0062
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0062
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0061
153	Dopamine beta-hydroxylase	DBH	0.0061
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.006
819	Penicillin-binding protein 4	dacB	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
572	Integrin alpha-L	ITGAL	0.0059
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0059
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0059
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0058
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0058
2958	Probable tautomerase ydcE	pptA	0.0058
2573	Cocaine esterase	cocE	0.0058
7263	Cocaine esterase	Not Available	0.0058
1656	CYP2B protein	CYP2B	0.0058
3115	Ras-related protein Rab-9	RAB9A	0.0057
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
1010	Cytochrome P450 51A1	CYP51A1	0.0057
239	Coagulation factor X	F10	0.0057
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0057
3007	Carbonic anhydrase 12	CA12	0.0057
4205	Carbonic anhydrase 9	CA9	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0056
3830	Calreticulin	CALR	0.0055
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0055
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0055
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
921	Glutamate receptor 2	GRIA2	0.0054
1649	Small inducible cytokine A2	CCL2	0.0054
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0053
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0053
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0053
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
811	Translocator protein	TSPO	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0052
6035	Nuclear receptor ROR-beta	RORB	0.0051
6034	Hydroxyindole O-methyltransferase	ASMT	0.0051
6036	Eosinophil peroxidase	EPX	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0051
613	Atrial natriuretic peptide receptor A	NPR1	0.005
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.005
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.005
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.005
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.005
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.005
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.005
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.005
4041	Microsomal glutathione S-transferase 2	MGST2	0.005
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0049
634	Squalene monooxygenase	SQLE	0.0049
7196	Squalene monooxygenase	ERG1	0.0049
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0049
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0049
131	Synaptic vesicular amine transporter	SLC18A2	0.0048
1525	Heparin-binding growth factor 2	FGF2	0.0048
1123	Eosinophil cationic protein	RNASE3	0.0047
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0047
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0047
936	Ephrin type-A receptor 2	EPHA2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
4034	Glutaredoxin-1	GLRX	0.0046
1928	Leukotriene C4 synthase	LTC4S	0.0046
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0046
4037	Hypothetical protein	GPX1	0.0046
4297	Hypothetical protein	SP_1951	0.0046
4521	Hypothetical protein	BC_2969	0.0046
4540	Hypothetical protein	TM_1070	0.0046
4555	Hypothetical protein	MT1739	0.0046
4569	Hypothetical protein	mshD	0.0046
4578	Hypothetical protein	PA3270	0.0046
4747	Hypothetical protein	PA3967	0.0046
5177	Hypothetical protein	TM_0096	0.0046
5194	Hypothetical protein	PA1204	0.0046
5240	Hypothetical protein	Rv2991	0.0046
5370	Hypothetical protein	TM_1158	0.0046
5710	Hypothetical protein	Tb927.5.1360	0.0046
4029	Microsomal glutathione S-transferase 3	MGST3	0.0046
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0046
907	Glutathione peroxidase 2	GPX2	0.0046
4032	Microsomal glutathione S-transferase 1	MGST1	0.0046
910	Epididymal secretory glutathione peroxidase	GPX5	0.0046
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0046
4036	Glutathione peroxidase 6	GPX6	0.0046
903	Glutathione S-transferase A5	GSTA5	0.0046
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0046
4040	Glutathione peroxidase 7	GPX7	0.0046
911	Glutathione peroxidase 3	GPX3	0.0046
906	Glutathione peroxidase 1	GPX1	0.0046
900	Glutathione S-transferase A4	GSTA4	0.0046
4035	Glutathione S-transferase Mu 5	GSTM5	0.0046
4033	S-formylglutathione hydrolase	ESD	0.0046
4042	Glutathione transferase omega-2	GSTO2	0.0046
4038	Glutathione peroxidase 4	GPX4	0.0046
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0046
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
1618	High affinity nerve growth factor receptor	NTRK1	0.0046
814	Ryanodine receptor 1	RYR1	0.0046
6102	Arylamine N-acetyltransferase 2	NAT2	0.0046
173	Toll-like receptor 7	TLR7	0.0046
2232	Interleukin-5	IL5	0.0045
1593	Mucin-2	MUC2	0.0045
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0045
823	Fibroblast growth factor receptor 2	FGFR2	0.0045
291	Nitric-oxide synthase, endothelial	NOS3	0.0045
2693	Heat-labile enterotoxin B chain	eltB	0.0044
765	Indoleamine 2,3-dioxygenase	IDO1	0.0044
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0044
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0044
84	Nuclear receptor 0B1	NR0B1	0.0044
76	Nitric-oxide synthase, brain	NOS1	0.0044
106	Cannabinoid receptor 2	CNR2	0.0044
6645	D-amino-acid oxidase	DAO	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0043
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0042
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
760	Fibroblast growth factor 1	FGF1	0.0042
898	Glutathione S-transferase A3	GSTA3	0.0042
897	Glutathione S-transferase kappa 1	GSTK1	0.0042
976	Platelet glycoprotein IX	GP9	0.0042
427	Substance-P receptor	TACR1	0.0041
909	Maleylacetoacetate isomerase	GSTZ1	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
408	Riboflavin kinase	RFK	0.0041
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
905	Glutathione transferase omega-1	GSTO1	0.004
899	Glutathione S-transferase Mu 3	GSTM3	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
484	Tyrosine-protein kinase ABL2	ABL2	0.004
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0039
6824	Tyrosine-protein kinase Lyn	LYN	0.0039
4031	Glutathione S-transferase A1	GSTA1	0.0039
2408	Tyrosine-protein kinase SYK	SYK	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
2236	Casein kinase II subunit alpha	CSNK2A1	0.0037
2165	Glutathione S-transferase Mu 2	GSTM2	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
207	Glutathione synthetase	GSS	0.0036
5269	Glutathione synthetase	gshB	0.0036
707	72 kDa type IV collagenase	MMP2	0.0036
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0036
856	Vitamin D3 receptor	VDR	0.0035
997	Protein kinase C beta type	PRKCB	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6432	Transporter	snf	0.0035
4103	Proteasome subunit beta type 2	PSMB2	0.0035
4102	Proteasome subunit beta type 5	PSMB5	0.0035
4101	Proteasome subunit beta type 1	PSMB1	0.0035
1025	Aquaporin-1	AQP1	0.0035
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0035
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0035
901	Glutathione S-transferase Mu 4	GSTM4	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
94	5-hydroxytryptamine 4 receptor	HTR4	0.0034
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0032
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0032
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0032
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0031
705	Glutamate receptor 1	GRIA1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
1039	Histone deacetylase 9	HDAC9	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
780	Retinoic acid receptor RXR-gamma	RXRG	0.003
654	Flavin reductase	BLVRB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
319	Opioid receptor, sigma 1	OPRS1	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
2216	Fibroblast growth factor receptor 4	FGFR4	0.0027
1196	Complement decay-accelerating factor	CD55	0.0027
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2300	Lysozyme	E	0.0027
3633	Lysozyme	R	0.0027
5597	Lysozyme	17	0.0027
88	Retinoic acid receptor RXR-beta	RXRB	0.0027
822	Aldose reductase	AKR1B1	0.0027
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0026
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0026
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0026
1864	RET proto-oncogene	RET	0.0026
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0026
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0026
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6859	Protein S100-A4	S100A4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
482	Glycine receptor subunit alpha-1	GLRA1	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
4311	tRNA	TRDMT1	0.0023
4325	tRNA	trmD	0.0023
4328	tRNA	trmD	0.0023
1275	Estrogen sulfotransferase	SULT1E1	0.0023
5682	Ribonuclease pancreatic	RNASE1	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0022
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
5798	Mitogen-activated protein kinase 11	MAPK11	0.0022
2417	Chloramphenicol acetyltransferase	cat	0.0022
3278	Chloramphenicol acetyltransferase	cat	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
54	Prothrombin	F2	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
2810	Dr hemagglutinin structural subunit	draA	0.0022
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0022
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0022
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
2091	Endoplasmin	HSP90B1	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0021
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.002
4203	Histamine N-methyltransferase	HNMT	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
6221	Steroid hormone receptor ERR1	ESRRA	0.0019
518	Peroxidase/catalase T	katG	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
1374	Natriuretic peptides B	NPPB	0.0018
1827	Gap junction alpha-1 protein	GJA1	0.0018
1908	Vascular cell adhesion protein 1	VCAM1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
162	Retinoic acid receptor gamma-1	RARG	0.0018
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0017
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0016
1243	Cathepsin D	CTSD	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6755	Poliovirus receptor	PVR	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0015
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1541	Metalloproteinase	mmp20	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
4992	Cytochrome c peroxidase	Not Available	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
444	Alcohol dehydrogenase 1B	ADH1B	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
694	Matrix protein 2	M	0.0012
164	Histamine H4 receptor	HRH4	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0012
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
292	Activin receptor type-1	ACVR1	0.0012
1295	Fatty acid synthase	FASN	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
3937	Fatty-acid amide hydrolase	FAAH	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
6459	Glycodelin	PAEP	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0011
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0011
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
251	Alcohol dehydrogenase 1A	ADH1A	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
820	Glycine receptor subunit alpha-2	GLRA2	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.001
3583	6-phosphogluconolactonase	pgl	0.001
268	Adenosine A2b receptor	ADORA2B	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
174	Sigma 1-type opioid receptor	SIGMAR1	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
798	Osteocalcin	BGLAP	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00286 - Conjugated Estrogens

Targets

Enzymes

Transporters

Predictions