DT-Web

DB01586 - Ursodeoxycholic acid


Identification
Name Ursodeoxycholic acid
Accession Number DB01586
Type small molecule
Description Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 392.572
Groups approved
Monoisotopic Weight 392.292659768
Pharmacology
Indication The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery.
Mechanism of action Ursodeoxycholic acid reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells. The main mechanism if anticholelithic. Although the exact process of ursodiol's anticholelithic action is not completely understood, it is thought that the drug is concentrated in bile and decreases biliary cholesterol by suppressing hepatic synthesis and secretion of cholesterol and by inhibiting its intestinal absorption. The reduced cholesterol saturation permits the gradual solubilization of cholesterol from gallstones, resulting in their eventual dissolution.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Only small quantities of ursodiol appear in the systemic circulation and very small amounts are excreted into urine. Eighty percent of lithocholic acid formed in the small bowel is excreted in the feces, but the 20% that is absorbed is sulfated at the 3-hydroxyl group in the liver to relatively insoluble lithocholyl conjugates which are excreted into bile and lost in feces.
Toxicity Neither accidental nor intentional overdosing with ursodeoxycholic acid has been reported. Doses of ursodeoxycholic acid in the range of 16-20 mg/kg/day have been tolerated for 6-37 months without symptoms by 7 patients. The LD50 for ursodeoxycholic acid in rats is over 5000 mg/kg given over 7-10 days and over 7500 mg/kg for mice. The most likely manifestation of severe overdose with ursodeoxycholic acid would probably be diarrhea, which should be treated symptomatically.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cholestyramine The resin decreases the effect of ursodiol
Clofibrate The fibric acid derivative decreases the effect of ursodiol
Clomifene Estrogens decreases the effect of ursodiol
Colesevelam Bile Acid Sequestrants may decrease the serum concentration of Ursodiol. Consider administration of ursodiol 5 hours or more after bile acid sequestrants to minimize ursodiol adsorption in the gastrointestinal tract. Monitor for decreased therapeutic effects of ursodiol in patients receiving bile acid sequestrants.
Colestipol The resin decreases the effect of ursodiol
Conjugated Estrogens Estrogens decreases the effect of ursodiol
Cyclosporine Ursodiol increases the levels of cyclosporine
Diethylstilbestrol Estrogens decreases the effect of ursodiol
Estradiol Estrogens decreases the effect of ursodiol
Ethinyl Estradiol Estrogens decreases the effect of ursodiol
Fenofibrate The fibric acid derivative decreases the effect of ursodiol
Gemfibrozil The fibric acid derivative decreases the effect of ursodiol
Food Interactions Not Available

Targets


Aldo-keto reductase family 1 member C2
Name Aldo-keto reductase family 1 member C2
Gene Name AKR1C2
Pharmacological action yes
Actions inducer
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Amaral JD, Sola S, Steer CJ, Rodrigues CM: Role of nuclear steroid receptors in apoptosis. Curr Med Chem. 2009;16(29):3886-902. - Pubmed
DTHybrid score 0.3285

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.226

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions substrate,inhibitor,inducer
References
  • Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD: Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem. 2001 Oct 19;276(42):39411-8. Epub 2001 Aug 16. - Pubmed
  • Green RM, Hoda F, Ward KL: Molecular cloning and characterization of the murine bile salt export pump. Gene. 2000 Jan 4;241(1):117-23. - Pubmed
  • Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
DTHybrid score 0.326
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate,inhibitor,inducer
References
  • Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M: Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 2001 Jul;121(1):170-83. - Pubmed
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ: Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. - Pubmed
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology. 1994 Aug;20(2):411-6. - Pubmed
  • Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G829-39. Epub 2003 Jul 3. - Pubmed
DTHybrid score 0.3632
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA: Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15. Epub 2001 Nov 12. - Pubmed
  • Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M: Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 2001 Jul;121(1):170-83. - Pubmed
DTHybrid score 0.3053
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. - Pubmed
DTHybrid score 0.2345
Ileal sodium/bile acid cotransporter
Name Ileal sodium/bile acid cotransporter
Gene Name SLC10A2
Actions inhibitor
References
  • Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA: Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69. - Pubmed
  • Saeki T, Matoba K, Furukawa H, Kirifuji K, Kanamoto R, Iwami K: Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter. J Biochem. 1999 Apr;125(4):846-51. - Pubmed
  • Saeki T, Takahashi N, Kanamoto R, Iwami K: Characterization of cloned mouse Na+/taurocholate cotransporting polypeptide by transient expression in COS-7 cells. Biosci Biotechnol Biochem. 2002 May;66(5):1116-8. - Pubmed
DTHybrid score 0.3499
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions substrate,inhibitor
References
  • Boyer JL, Ng OC, Ananthanarayanan M, Hofmann AF, Schteingart CD, Hagenbuch B, Stieger B, Meier PJ: Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells. Am J Physiol. 1994 Mar;266(3 Pt 1):G382-7. - Pubmed
  • Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
DTHybrid score 0.3216

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1862
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.1837
4512 Cytochrome P450 3A4 CYP3A4 0.1747
4757 Cytochrome P450 2C9 CYP2C9 0.1353
4924 Cytochrome P450 2C8 CYP2C8 0.1247
6142 Solute carrier family 22 member 8 SLC22A8 0.1214
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1202
862 Multidrug resistance-associated protein 1 ABCC1 0.1135
1729 Solute carrier family 22 member 6 SLC22A6 0.1123
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1057
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.1046
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1032
6016 Cytochrome P450 2C19 CYP2C19 0.103
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.093
4200 Cytochrome P450 1A2 CYP1A2 0.091
4118 Cytochrome P450 3A5 CYP3A5 0.0899
4119 Cytochrome P450 2D6 CYP2D6 0.0872
6107 Cytochrome P450 3A7 CYP3A7 0.0749
587 Serum albumin ALB 0.0749
6030 Cytochrome P450 2B6 CYP2B6 0.0652
6145 Solute carrier family 22 member 1 SLC22A1 0.0648
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.06
6143 Solute carrier family 22 member 7 SLC22A7 0.059
6024 Cytochrome P450 1A1 CYP1A1 0.0581
6148 Multidrug resistance-associated protein 7 ABCC10 0.0556
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.052
1024 Solute carrier family 22 member 11 SLC22A11 0.0516
6136 Multidrug resistance-associated protein 5 ABCC5 0.0487
5718 Cytochrome P450 2A6 CYP2A6 0.0473
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0462
3587 Gastrotropin FABP6 0.0433
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0416
136 Estrogen receptor ESR1 0.0401
290 Prostaglandin G/H synthase 2 PTGS2 0.0394
6144 Solute carrier family 22 member 2 SLC22A2 0.0392
33 Cystine/glutamate transporter SLC7A11 0.0376
338 DNA polymerase UL30 0.037
379 DNA polymerase UL54 0.037
697 DNA polymerase ORF28 0.037
2482 DNA polymerase 43 0.037
4104 DNA polymerase BALF5 0.037
20 Prostaglandin G/H synthase 1 PTGS1 0.0358
1898 Cytochrome P450 1B1 CYP1B1 0.0353
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0343
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0343
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0337
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0336
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0335
6167 Organic solute transporter subunit beta OSTB 0.0324
6166 Organic solute transporter subunit alpha OSTA 0.0324
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0299
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0295
6137 Multidrug resistance-associated protein 6 ABCC6 0.0291
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0289
738 Monocarboxylate transporter 1 SLC16A1 0.0284
118 Organic cation/carnitine transporter 2 SLC22A5 0.028
3811 Cytochrome P450 19A1 CYP19A1 0.0266
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0258
4604 Liver carboxylesterase 1 CES1 0.0254
6147 Solute carrier family 22 member 3 SLC22A3 0.0251
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0226
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0226
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0226
509 Thymidine kinase TK 0.0216
570 Thymidine kinase TK 0.0216
2559 Thymidine kinase TK 0.0216
3430 Thymidine kinase tdk 0.0216
3518 Thymidine kinase TK 0.0216
5301 Thymidine kinase tdk 0.0216
5771 Thymidine kinase ORF36 0.0216
7009 Thymidine kinase ORF36 0.0216
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0214
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0209
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0209
2417 Chloramphenicol acetyltransferase cat 0.0207
3278 Chloramphenicol acetyltransferase cat 0.0207
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0207
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0197
904 Glutathione S-transferase P GSTP1 0.019
5626 Nucleoside diphosphate kinase B NME2 0.0187
2391 Ferrochelatase hemH 0.0185
6502 Ferrochelatase DKFZp686P18130 0.0185
1591 Ferrochelatase, mitochondrial FECH 0.0185
833 Organic cation/carnitine transporter 1 SLC22A4 0.0185
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0183
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0181
3270 Elongation factor G fusA 0.0181
594 Thyroxine-binding globulin SERPINA7 0.0179
468 Cytochrome P450 4A11 CYP4A11 0.0178
13 Aminomethyltransferase, mitochondrial AMT 0.0176
24 Thymidylate synthase TMP1 0.0174
359 Thymidylate synthase TYMS 0.0174
2626 Thymidylate synthase thyA 0.0174
2729 Thymidylate synthase thyA 0.0174
5352 Thymidylate synthase THYA 0.0174
2808 Chloramphenicol acetyltransferase 3 cat3 0.0174
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0167
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0167
758 Thyroid hormone receptor alpha THRA 0.0167
817 DNA topoisomerase 2-alpha TOP2A 0.0166
380 Cytochrome P450 17A1 CYP17A1 0.0159
737 Mineralocorticoid receptor NR3C2 0.0159
6149 Solute carrier family 22 member 10 SLC22A10 0.0158
6493 Cytochrome c oxidase subunit 6C COX6C 0.0158
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0158
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0158
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0158
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0158
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0158
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0158
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0158
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0158
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0158
6559 Cytochrome c oxidase subunit 2 ctaC 0.0158
6669 Cytochrome c oxidase subunit 2 ctaC 0.0158
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0158
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0158
6558 Cytochrome c oxidase subunit 1 ctaD 0.0158
70 Type-1 angiotensin II receptor AGTR1 0.0158
683 Potassium transporter GK0582 0.0156
346 Thyroid hormone receptor beta-1 THRB 0.015
5294 Nucleoside diphosphate kinase A NME1 0.015
3947 Xanthine dehydrogenase/oxidase XDH 0.0149
6031 Cytochrome P450 3A43 CYP3A43 0.0148
3809 Estrogen-related receptor gamma ESRRG 0.0148
2540 Choloylglycine hydrolase cbh 0.0146
517 Alcohol dehydrogenase 1C ADH1C 0.0145
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0142
373 Transthyretin TTR 0.0138
6501 Fatty acid-binding protein, liver FABP1 0.0136
260 Cytochrome P450 51 ERG11 0.0131
761 Cytochrome P450 51 ERG11 0.0131
3163 Cytochrome P450 51 cyp51 0.0131
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.013
6106 Cytochrome P450 2C18 CYP2C18 0.0129
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0122
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
492 Histamine H1 receptor HRH1 0.0119
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0119
731 HIV-1 protease HIV-1 protease 0.0116
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
161 Tubulin beta chain TUBB 0.0113
312 Tubulin beta chain TUB2 0.0113
49 Endothelin B receptor EDNRB 0.0113
146 Androgen receptor AR 0.0113
614 Progesterone receptor PGR 0.0112
663 Solute carrier family 12 member 4 SLC12A4 0.0112
53 Solute carrier family 12 member 5 SLC12A5 0.0112
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
6500 Phospholipase A2 PLA2G1B 0.0111
3917 Methylenetetrahydrofolate reductase MTHFR 0.0111
1650 Heme carrier protein 1 SLC46A1 0.0111
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.011
871 Glucocorticoid receptor NR3C1 0.011
444 Alcohol dehydrogenase 1B ADH1B 0.011
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0109
244 Angiotensin-converting enzyme ACE 0.0108
2443 Azurin azu 0.0108
578 Endothelin-1 receptor EDNRA 0.0106
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0106
756 Sex hormone-binding globulin SHBG 0.0105
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0104
310 Solute carrier family 12 member 2 SLC12A2 0.0104
165 FL cytokine receptor FLT3 0.0104
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0102
3941 Amine oxidase [flavin-containing] A MAOA 0.0101
558 Solute carrier family 12 member 1 SLC12A1 0.0101
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0101
869 Estrogen receptor beta ESR2 0.0099
4120 NADPH--cytochrome P450 reductase POR 0.0099
293 Gamma-glutamyl hydrolase GGH 0.0099
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0098
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0098
6151 Monocarboxylate transporter 10 SLC16A10 0.0098
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0097
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0097
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0096
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0096
666 NADP-dependent malic enzyme ME1 0.0096
646 Malate dehydrogenase, cytoplasmic MDH1 0.0095
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0094
6218 Pannexin-1 PANX1 0.0094
6085 Fatty acid-binding protein, intestinal FABP2 0.0093
365 Dihydrofolate reductase DHFR 0.0092
2381 Dihydrofolate reductase DFR1 0.0092
2833 Dihydrofolate reductase Not Available 0.0092
2931 Dihydrofolate reductase folA 0.0092
3544 Dihydrofolate reductase folA 0.0092
3682 Dihydrofolate reductase folA 0.0092
6642 Dihydrofolate reductase folA 0.0092
6756 Dihydrofolate reductase dfrA 0.0092
824 Sodium-dependent serotonin transporter SLC6A4 0.009
11 NAD(P) transhydrogenase, mitochondrial NNT 0.009
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0089
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0089
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0089
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0089
131 Synaptic vesicular amine transporter SLC18A2 0.0088
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
3810 Catechol O-methyltransferase COMT 0.0088
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0088
504 Mast/stem cell growth factor receptor KIT 0.0087
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0087
341 5-hydroxytryptamine 3 receptor HTR3A 0.0086
6020 Aldehyde oxidase AOX1 0.0086
908 Glutathione S-transferase theta-1 GSTT1 0.0086
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0085
6042 Prostaglandin reductase 2 PTGR2 0.0085
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0084
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0084
4403 Protein iolS iolS 0.0084
5330 General stress protein 69 yhdN 0.0084
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0084
5322 Oxidoreductase ydhF ydhF 0.0084
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0084
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0084
5332 MtdA bifunctional protein mtdA 0.0084
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0084
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0084
3778 NAD(P) transhydrogenase subunit beta pntB 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0084
199 Monocarboxylate transporter 8 SLC16A2 0.0083
6033 High affinity interleukin-8 receptor A CXCR1 0.0083
273 Apoptosis regulator Bcl-2 BCL2 0.0083
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
26 Vascular endothelial growth factor receptor 3 FLT4 0.008
407 Vascular endothelial growth factor receptor 2 KDR 0.008
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
1313 Lactoylglutathione lyase GLO1 0.008
2981 Phospholipase A2, membrane associated PLA2G2A 0.008
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0079
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0079
469 Annexin A1 ANXA1 0.0079
275 Arachidonate 5-lipoxygenase ALOX5 0.0078
1405 Thiopurine S-methyltransferase TPMT 0.0078
6043 Putative G-protein coupled receptor 44 GPR44 0.0077
32 Vascular endothelial growth factor receptor 1 FLT1 0.0077
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0076
1629 Transcription factor AP-1 JUN 0.0076
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0076
556 Alpha-1A adrenergic receptor ADRA1A 0.0075
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0074
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0074
1010 Cytochrome P450 51A1 CYP51A1 0.0074
489 Monocarboxylate transporter 2 SLC16A7 0.0074
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0074
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0073
320 5-hydroxytryptamine 1A receptor HTR1A 0.0073
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0072
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0072
5073 Ferredoxin--NADP reductase petH 0.0072
5076 Ferredoxin--NADP reductase fpr 0.0072
5119 Ferredoxin--NADP reductase petH 0.0072
5121 Ferredoxin--NADP reductase fpr 0.0072
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0072
654 Flavin reductase BLVRB 0.0072
228 Beta platelet-derived growth factor receptor PDGFRB 0.0072
1648 Elastin ELN 0.0072
6014 Cytochrome P450 2A13 CYP2A13 0.0072
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0071
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0071
3923 Cholinesterase BCHE 0.0071
185 Vasopressin V1a receptor AVPR1A 0.0071
4582 Putative pteridine reductase 2 ptr2 0.0071
5328 Prostaglandin F synthase Tb11.02.2310 0.0071
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0071
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.007
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.007
2286 Isocitrate dehydrogenase [NADP] icd 0.007
2302 Isocitrate dehydrogenase [NADP] icd 0.007
2771 Isocitrate dehydrogenase [NADP] icd 0.007
3446 NADP-dependent alcohol dehydrogenase adh 0.007
989 L-xylulose reductase DCXR 0.007
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.007
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.007
2636 Shikimate dehydrogenase aroE 0.007
3515 Shikimate dehydrogenase aroE 0.007
16 Adenosine A1 receptor ADORA1 0.007
502 5-hydroxytryptamine 2A receptor HTR2A 0.007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.007
6211 Tubulin epsilon chain TUBE1 0.007
6210 Tubulin delta chain TUBD1 0.007
6212 Tubulin gamma-1 chain TUBG1 0.007
322 Vasopressin V2 receptor AVPR2 0.007
6220 Aryl hydrocarbon receptor AHR 0.0069
777 Tumor necrosis factor TNF 0.0069
718 Folate receptor gamma FOLR3 0.0069
299 Folate receptor beta FOLR2 0.0069
804 Mitochondrial folate transporter/carrier SLC25A32 0.0069
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0068
831 D(2) dopamine receptor DRD2 0.0068
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0067
482 Glycine receptor subunit alpha-1 GLRA1 0.0065
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0065
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0064
3062 Aspartate-semialdehyde dehydrogenase asd 0.0064
6297 Prostaglandin reductase 1 PTGR1 0.0064
4192 DNA topoisomerase 2-beta TOP2B 0.0064
4531 Putative ketoacyl reductase actIII 0.0064
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0064
23 D(1A) dopamine receptor DRD1 0.0063
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0063
4122 Histone deacetylase 2 HDAC2 0.0063
29 Tubulin beta-1 chain TUBB1 0.0063
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0063
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
5482 Sialidase-2 NEU2 0.0062
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0062
2675 Pteridine reductase 1 PTR1 0.0062
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0062
2159 Quinone oxidoreductase CRYZ 0.0062
3685 Catabolite gene activator crp 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
76 Nitric-oxide synthase, brain NOS1 0.0061
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0061
1757 Myeloperoxidase MPO 0.0061
251 Alcohol dehydrogenase 1A ADH1A 0.0061
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
1124 Sepiapterin reductase SPR 0.006
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.006
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.006
465 Calmodulin CALM1 0.006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0059
751 Potassium channel subfamily K member 6 KCNK6 0.0059
896 Glutathione S-transferase Mu 1 GSTM1 0.0058
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0057
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0057
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0057
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0057
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0057
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0057
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0056
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0056
613 Atrial natriuretic peptide receptor A NPR1 0.0056
1852 Microtubule-associated protein 2 MAP2 0.0056
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0056
705 Glutamate receptor 1 GRIA1 0.0056
6163 Copper-transporting ATPase 2 ATP7B 0.0056
6165 Copper-transporting ATPase 1 ATP7A 0.0056
822 Aldose reductase AKR1B1 0.0055
7 Nitric oxide synthase, inducible NOS2 0.0055
172 Potassium channel subfamily K member 1 KCNK1 0.0054
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0054
3957 Adenosine deaminase ADA 0.0054
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0054
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0054
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0053
6146 High affinity copper uptake protein 1 SLC31A1 0.0053
84 Nuclear receptor 0B1 NR0B1 0.0053
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0053
4760 Mll3241 protein mll3241 0.0052
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0051
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.005
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.005
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.005
2449 Tubulin alpha-3 chain TUBA1A 0.005
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0049
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
885 5-hydroxytryptamine 1B receptor HTR1B 0.0049
1178 Adenosine A2a receptor ADORA2A 0.0048
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0048
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0048
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0048
1192 Sulfotransferase 1A1 SULT1A1 0.0048
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0047
632 Alpha-1B adrenergic receptor ADRA1B 0.0047
473 L-lactate dehydrogenase A chain LDHA 0.0047
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
284 DNA-directed RNA polymerase beta chain rpoB 0.0047
5773 DNA-directed RNA polymerase beta chain rpoB 0.0047
790 DNA polymerase subunit alpha B POLA2 0.0045
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0045
5818 Folate receptor alpha FOLR1 0.0045
2021 Thrombomodulin THBD 0.0045
6171 Solute carrier family 28 member 3 SLC28A3 0.0044
1630 Integrin beta-2 ITGB2 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0044
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0043
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0043
702 UMP-CMP kinase CMPK1 0.0043
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
6102 Arylamine N-acetyltransferase 2 NAT2 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
823 Fibroblast growth factor receptor 2 FGFR2 0.0041
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.004
725 5-hydroxytryptamine 1D receptor HTR1D 0.0039
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
5934 Cytochrome P450 26A1 CYP26A1 0.0039
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0038
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0038
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0038
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0037
976 Platelet glycoprotein IX GP9 0.0036
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0036
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0036
4773 Deoxycytidine kinase DCK 0.0036
6044 Serum paraoxonase/lactonase 3 PON3 0.0036
921 Glutamate receptor 2 GRIA2 0.0035
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0035
3939 Amine oxidase [flavin-containing] B MAOB 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0035
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0034
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
590 5-hydroxytryptamine 2C receptor HTR2C 0.0034
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0034
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0034
811 Translocator protein TSPO 0.0034
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
511 5-hydroxytryptamine 1F receptor HTR1F 0.0033
3932 Glutathione S-transferase A2 GSTA2 0.0033
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0033
572 Integrin alpha-L ITGAL 0.0033
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0033
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0033
4217 Telomerase reverse transcriptase TERT 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
4226 Uridine phosphorylase 2 UPP2 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
340 Apoptotic protease-activating factor 1 APAF1 0.0032
318 Alpha-2A adrenergic receptor ADRA2A 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0031
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0031
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0031
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0031
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0031
1792 Tissue-type plasminogen activator PLAT 0.0031
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0031
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0031
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0031
714 Glutathione reductase, mitochondrial GSR 0.0031
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0031
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0031
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.003
115 Penicillin-binding protein 2 mrdA 0.003
6069 Penicillin-binding protein 2 mrdA 0.003
6118 Penicillin-binding protein 2 penA 0.003
6187 Penicillin-binding protein 2 pbpA 0.003
6686 Penicillin-binding protein 2 pbp2 0.003
6939 Penicillin-binding protein 2 mrdA 0.003
7163 Penicillin-binding protein 2 pbpA 0.003
3856 Fibroblast growth factor receptor 3 FGFR3 0.003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.003
816 Biliverdin reductase A BLVRA 0.0029
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0029
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0029
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0029
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0029
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0029
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0029
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0029
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0029
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0029
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0029
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0029
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0029
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0029
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0029
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0029
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0029
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0029
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0029
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0029
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0029
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0029
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0029
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0029
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0029
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0029
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0029
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0029
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0029
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0029
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0029
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0029
107 C-4 methylsterol oxidase SC4MOL 0.0029
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0029
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0029
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0029
644 Heme oxygenase 2 HMOX2 0.0029
4982 Heme oxygenase 2 pbsA2 0.0029
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0029
729 GDP-L-fucose synthetase TSTA3 0.0029
3463 GDP-L-fucose synthetase fcl 0.0029
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0029
167 L-lactate dehydrogenase C chain LDHC 0.0029
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0029
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0029
206 3-keto-steroid reductase HSD17B7 0.0029
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0029
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0029
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0029
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0029
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0029
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0029
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0029
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0029
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0029
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0029
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0029
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0029
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0029
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0029
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0029
711 UDP-glucose 6-dehydrogenase UGDH 0.0029
3672 UDP-glucose 6-dehydrogenase hasB 0.0029
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0029
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0029
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0029
3726 D-3-phosphoglycerate dehydrogenase serA 0.0029
4291 D-3-phosphoglycerate dehydrogenase serA 0.0029
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0029
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0029
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0029
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0029
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0029
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0029
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0029
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0029
643 Peroxisomal bifunctional enzyme EHHADH 0.0029
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0029
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0029
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0029
34 7-dehydrocholesterol reductase DHCR7 0.0029
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
4225 Uridine phosphorylase 1 UPP1 0.0029
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0029
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0028
952 Dipeptidyl peptidase 4 DPP4 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0028
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0028
825 Arsenical pump-driving ATPase ASNA1 0.0028
3435 Arsenical pump-driving ATPase arsA 0.0028
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0028
1 Peptidoglycan synthetase ftsI ftsI 0.0028
4155 Peptidoglycan synthetase ftsI ftsI 0.0028
154 AFG3-like protein 2 AFG3L2 0.0028
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0028
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0028
733 Activin receptor type 1B ACVR1B 0.0028
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0028
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0028
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0028
395 ALK tyrosine kinase receptor Not Available 0.0028
390 Adenosine A3 receptor ADORA3 0.0028
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
645 Penicillin-binding protein 1A mrcA 0.0028
5805 Penicillin-binding protein 1A ponA 0.0028
6185 Penicillin-binding protein 1A mrcA 0.0028
6799 Penicillin-binding protein 1A pbpA 0.0028
413 Amidophosphoribosyltransferase PPAT 0.0028
2515 Amidophosphoribosyltransferase purF 0.0028
3714 Amidophosphoribosyltransferase purF 0.0028
847 Mu-type opioid receptor OPRM1 0.0027
3404 Exotoxin A eta 0.0027
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0027
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0026
396 Alcohol dehydrogenase 4 ADH4 0.0026
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0026
328 Sorbitol dehydrogenase SORD 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
597 Dihydropteridine reductase QDPR 0.0026
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0026
857 Malate dehydrogenase, mitochondrial MDH2 0.0026
638 D(3) dopamine receptor DRD3 0.0026
292 Activin receptor type-1 ACVR1 0.0026
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
849 Activated CDC42 kinase 1 TNK2 0.0025
1760 Aminopeptidase N ANPEP 0.0025
6843 Aminopeptidase N pepN 0.0025
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0025
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0025
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0025
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0025
2320 Thymidine kinase, cytosolic TK1 0.0025
117 Sterol O-acyltransferase 1 SOAT1 0.0025
5787 Angiopoietin-1 receptor TEK 0.0025
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0025
789 Alpha-1D adrenergic receptor ADRA1D 0.0024
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0024
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0024
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0024
297 Adenylate cyclase type 1 ADCY1 0.0024
12 Alcohol dehydrogenase class 3 ADH5 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
77 L-lactate dehydrogenase B chain LDHB 0.0024
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0024
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0024
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0024
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0024
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0024
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0024
6026 Alcohol dehydrogenase 6 ADH6 0.0024
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0024
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
627 11-cis retinol dehydrogenase RDH5 0.0023
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0023
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0023
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0023
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0023
358 Cystathionine beta-synthase CBS 0.0023
467 Delta-type opioid receptor OPRD1 0.0023
3639 Thymidine phosphorylase deoA 0.0023
3936 Thymidine phosphorylase TYMP 0.0023
626 Cysteine dioxygenase type 1 CDO1 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
696 Kappa-type opioid receptor OPRK1 0.0023
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0023
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0023
291 Nitric-oxide synthase, endothelial NOS3 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0022
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0022
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0022
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
569 Retinal dehydrogenase 2 ALDH1A2 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0021
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0021
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
611 Retinal dehydrogenase 1 ALDH1A1 0.0021
124 Histamine H2 receptor HRH2 0.0021
740 Argininosuccinate synthase ASS1 0.0021
865 Argininosuccinate synthase ASS1 0.0021
2680 Argininosuccinate synthase argG 0.0021
3194 Argininosuccinate synthase argG 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
2298 Cytochrome P450-cam camC 0.002
661 ADP/ATP translocase 1 SLC25A4 0.002
6021 Adenosine kinase ADK 0.002
518 Peroxidase/catalase T katG 0.002
4034 Glutaredoxin-1 GLRX 0.002
4043 Glutaredoxin-2, mitochondrial GLRX2 0.002
910 Epididymal secretory glutathione peroxidase GPX5 0.002
903 Glutathione S-transferase A5 GSTA5 0.002
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.002
4037 Hypothetical protein GPX1 0.002
4297 Hypothetical protein SP_1951 0.002
4521 Hypothetical protein BC_2969 0.002
4540 Hypothetical protein TM_1070 0.002
4555 Hypothetical protein MT1739 0.002
4569 Hypothetical protein mshD 0.002
4578 Hypothetical protein PA3270 0.002
4747 Hypothetical protein PA3967 0.002
5177 Hypothetical protein TM_0096 0.002
5194 Hypothetical protein PA1204 0.002
5240 Hypothetical protein Rv2991 0.002
5370 Hypothetical protein TM_1158 0.002
5710 Hypothetical protein Tb927.5.1360 0.002
1928 Leukotriene C4 synthase LTC4S 0.002
4029 Microsomal glutathione S-transferase 3 MGST3 0.002
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.002
4032 Microsomal glutathione S-transferase 1 MGST1 0.002
4036 Glutathione peroxidase 6 GPX6 0.002
911 Glutathione peroxidase 3 GPX3 0.002
4040 Glutathione peroxidase 7 GPX7 0.002
907 Glutathione peroxidase 2 GPX2 0.002
906 Glutathione peroxidase 1 GPX1 0.002
4035 Glutathione S-transferase Mu 5 GSTM5 0.002
900 Glutathione S-transferase A4 GSTA4 0.002
4042 Glutathione transferase omega-2 GSTO2 0.002
4038 Glutathione peroxidase 4 GPX4 0.002
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.002
4033 S-formylglutathione hydrolase ESD 0.002
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.002
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.002
80 Peroxisome proliferator-activated receptor alpha PPARA 0.002
592 Carbonic anhydrase 4 CA4 0.002
810 Heme oxygenase 1 HMOX1 0.0019
3391 Heme oxygenase 1 pbsA1 0.0019
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0019
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
563 Thyroid peroxidase TPO 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
713 Sodium-dependent dopamine transporter SLC6A3 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
279 Tyrosinase TYR 0.0019
295 Carbonic anhydrase 1 CA1 0.0019
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0019
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
3319 Hydroxyacylglutathione hydrolase HAGH 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
898 Glutathione S-transferase A3 GSTA3 0.0018
897 Glutathione S-transferase kappa 1 GSTK1 0.0018
909 Maleylacetoacetate isomerase GSTZ1 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
899 Glutathione S-transferase Mu 3 GSTM3 0.0017
905 Glutathione transferase omega-1 GSTO1 0.0017
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0017
4041 Microsomal glutathione S-transferase 2 MGST2 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
432 D(4) dopamine receptor DRD4 0.0016
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0016
2165 Glutathione S-transferase Mu 2 GSTM2 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0016
207 Glutathione synthetase GSS 0.0016
5269 Glutathione synthetase gshB 0.0016
378 Alpha-2C adrenergic receptor ADRA2C 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
122 P2Y purinoceptor 12 P2RY12 0.0015
901 Glutathione S-transferase Mu 4 GSTM4 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
1353 DNA topoisomerase 1 TOP1 0.0014
3552 DNA topoisomerase 1 topA 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0014
4031 Glutathione S-transferase A1 GSTA1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
1256 5-hydroxytryptamine 6 receptor HTR6 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
814 Ryanodine receptor 1 RYR1 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
6432 Transporter snf 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
716 5-hydroxytryptamine 7 receptor HTR7 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
268 Adenosine A2b receptor ADORA2B 0.0011
820 Glycine receptor subunit alpha-2 GLRA2 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
193 Beta-1 adrenergic receptor ADRB1 0.001
6131 Carbonic anhydrase 14 CA14 0.001
183 Vascular endothelial growth factor A VEGFA 0.001
766 Beta-2 adrenergic receptor ADRB2 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
997 Protein kinase C beta type PRKCB 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
1050 Bile salt sulfotransferase SULT2A1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
4311 tRNA TRDMT1 0.0008
4325 tRNA trmD 0.0008
4328 tRNA trmD 0.0008
6459 Glycodelin PAEP 0.0008
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
2802 Endoglucanase G celCCG 0.0007
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0007
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0007
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0007
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
2207 Rhodopsin RHO 0.0006
239 Coagulation factor X F10 0.0006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1618 High affinity nerve growth factor receptor NTRK1 0.0006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
164 Histamine H4 receptor HRH4 0.0005
54 Prothrombin F2 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
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