DT-Web: DB00636

Identification

Name

Clofibrate

Accession Number

DB00636 (APRD00879)

Type

small molecule

Description

A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

242.699

Groups

approved

Monoisotopic Weight

242.070972053

Pharmacology

Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet. This helps control high cholesterol and high triglyceride levels.

Mechanism of action

Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Clofibrate also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. Also, as a fibrate, Clofibrate is an agonist of the PPAR-? receptor[4] in muscle, liver, and other tissues. This agonism ultimately leads to modification in gene expression resulting in increased beta-oxidation, decreased triglyceride secretion, increased HDL, increased lipoprotein lipase activity.

Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Protein binding

Highly protein-bound (95% to 97%).

Biotransformation

Hepatic and gastrointestinal: rapid de-esterification occurs in the gastrointestinal tract and/or on first-pass metabolism to produce the active form, clofibric acid (chlorophenoxy isobutyric acid [CPIB]).

Route of elimination

Not Available

Toxicity

Oral, mouse: LD₅₀ = 1220 mg/kg; Oral, rabbit: LD₅₀ = 1370 mg/kg; Oral, rat: LD₅₀ = 940 mg/kg. No reported case of overdosage in humans.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The fibrate increases the anticoagulant effect
Acetohexamide	Clofibrate may increase the effect of sulfonylurea, acetohexamide.
Anisindione	The fibrate increases the anticoagulant effect
Chlorpropamide	Clofibrate may increase the effect of sulfonylurea, chlorpropamide.
Dicumarol	The fibrate increases the anticoagulant effect
Gliclazide	Clofibrate may increase the effect of sulfonylurea, gliclazide.
Glipizide	Clofibrate may increase the effect of sulfonylurea, glipizide.
Glisoxepide	Clofibrate may increase the effect of sulfonylurea, glisoxepide.
Glyburide	Clofibrate may increase the effect of sulfonylurea, glibenclamide.
Glycodiazine	Clofibrate may increase the effect of sulfonylurea, glycodiazine.
Insulin Aspart	Increases the effect of insulin
Insulin Detemir	Increases the effect of insulin
Insulin Glulisine	Increases the effect of insulin
Tolazamide	Clofibrate may increase the effect of sulfonylurea, tolazamide.
Tolbutamide	Clofibrate may increase the effect of sulfonylurea, tolbutamide.
Ursodeoxycholic acid	The fibric acid derivative decreases the effect of ursodiol
Warfarin	The fibrate increases the anticoagulant effect

Food Interactions

Take with food, since it may reduce gastric irritation.

Peroxisome proliferator-activated receptor alpha
Name	Peroxisome proliferator-activated receptor alpha
Gene Name	PPARA
Pharmacological action	yes
Actions	agonist
References	Barclay TB, Peters JM, Sewer MB, Ferrari L, Gonzalez FJ, Morgan ET: Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. J Pharmacol Exp Ther. 1999 Sep;290(3):1250-7. - Pubmed Murata M, Kaji H, Takahashi Y, Iida K, Mizuno I, Okimura Y, Abe H, Chihara K: Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro. Biochem Biophys Res Commun. 2000 Apr 13;270(2):343-8. - Pubmed Hunt MC, Lindquist PJ, Peters JM, Gonzalez FJ, Diczfalusy U, Alexson SE: Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases. J Lipid Res. 2000 May;41(5):814-23. - Pubmed Casas F, Domenjoud L, Rochard P, Hatier R, Rodier A, Daury L, Bianchi A, Kremarik-Bouillaud P, Becuwe P, Keller J, Schohn H, Wrutniak-Cabello C, Cabello G, Dauca M: A 45 kDa protein related to PPARgamma2, induced by peroxisome proliferators, is located in the mitochondrial matrix. FEBS Lett. 2000 Jul 28;478(1-2):4-8. - Pubmed Komuves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR: Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol. 2000 Sep;115(3):353-60. - Pubmed Gelosa P, Banfi C, Gianella A, Brioschi M, Pignieri A, Nobili E, Castiglioni L, Cimino M, Tremoli E, Sironi L: PPAR-alpha agonism prevents the oxidative stress and inflammatory processes involved in brain and renal damage in stroke-prone rats. J Pharmacol Exp Ther. 2010 Jul 29. - Pubmed Palkar PS, Anderson CR, Ferry CH, Gonzalez FJ, Peters JM: Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development. Toxicology. 2010 Jul 15. - Pubmed
DTHybrid score	0.4899

Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.324
Glutathione S-transferase A2
Name	Glutathione S-transferase A2
Gene Name	GSTA2
Actions	inhibitor
References	Foliot A, Touchard D, Mallet L: Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate. Biochem Pharmacol. 1986 May 15;35(10):1685-90. - Pubmed Foliot A, Touchard D, Celier C: Impairment of hepatic glutathione S-transferase activity as a cause of reduced biliary sulfobromophthalein excretion in clofibrate-treated rats. Biochem Pharmacol. 1984 Sep 15;33(18):2829-34. - Pubmed
DTHybrid score	0.2184
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5572
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3156
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3493
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3246
Cytochrome P450 4A11
Name	Cytochrome P450 4A11
Gene Name	CYP4A11
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.1627

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.2635
4757	Cytochrome P450 2C9	CYP2C9	0.2516
4119	Cytochrome P450 2D6	CYP2D6	0.2353
6016	Cytochrome P450 2C19	CYP2C19	0.2246
4924	Cytochrome P450 2C8	CYP2C8	0.2165
1588	Multidrug resistance protein 1	ABCB1	0.1755
4118	Cytochrome P450 3A5	CYP3A5	0.1585
6228	Nuclear receptor coactivator 1	NCOA1	0.1545
5841	Insulin-like growth factor IB	IGF1	0.1126
6107	Cytochrome P450 3A7	CYP3A7	0.1003
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0955
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0692
587	Serum albumin	ALB	0.0677
6106	Cytochrome P450 2C18	CYP2C18	0.0668
4031	Glutathione S-transferase A1	GSTA1	0.0666
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0637
1898	Cytochrome P450 1B1	CYP1B1	0.0625
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.062
896	Glutathione S-transferase Mu 1	GSTM1	0.0574
3811	Cytochrome P450 19A1	CYP19A1	0.051
1541	Metalloproteinase	mmp20	0.0482
20	Prostaglandin G/H synthase 1	PTGS1	0.0481
1729	Solute carrier family 22 member 6	SLC22A6	0.0441
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0436
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0404
4041	Microsomal glutathione S-transferase 2	MGST2	0.0402
492	Histamine H1 receptor	HRH1	0.0386
904	Glutathione S-transferase P	GSTP1	0.0382
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.038
776	Bile salt export pump	ABCB11	0.0347
3947	Xanthine dehydrogenase/oxidase	XDH	0.0346
136	Estrogen receptor	ESR1	0.0341
862	Multidrug resistance-associated protein 1	ABCC1	0.0337
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0336
777	Tumor necrosis factor	TNF	0.0332
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0311
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.03
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0295
824	Sodium-dependent serotonin transporter	SLC6A4	0.0293
871	Glucocorticoid receptor	NR3C1	0.0286
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.028
558	Solute carrier family 12 member 1	SLC12A1	0.0278
2112	Toll-like receptor 9	TLR9	0.0274
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0271
6144	Solute carrier family 22 member 2	SLC22A2	0.0271
85	Growth hormone receptor	GHR	0.0266
1405	Thiopurine S-methyltransferase	TPMT	0.0265
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0256
6014	Cytochrome P450 2A13	CYP2A13	0.025
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0249
482	Glycine receptor subunit alpha-1	GLRA1	0.0248
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0245
290	Prostaglandin G/H synthase 2	PTGS2	0.0244
260	Cytochrome P450 51	ERG11	0.0242
761	Cytochrome P450 51	ERG11	0.0242
3163	Cytochrome P450 51	cyp51	0.0242
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0237
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0236
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0236
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0234
556	Alpha-1A adrenergic receptor	ADRA1A	0.0232
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0231
6031	Cytochrome P450 3A43	CYP3A43	0.0228
3923	Cholinesterase	BCHE	0.0225
502	5-hydroxytryptamine 2A receptor	HTR2A	0.022
6145	Solute carrier family 22 member 1	SLC22A1	0.0218
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0213
51	Muscarinic acetylcholine receptor M3	CHRM3	0.021
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0205
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0205
831	D(2) dopamine receptor	DRD2	0.0204
251	Alcohol dehydrogenase 1A	ADH1A	0.0201
118	Organic cation/carnitine transporter 2	SLC22A5	0.0201
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.02
84	Nuclear receptor 0B1	NR0B1	0.0199
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0197
465	Calmodulin	CALM1	0.0197
6136	Multidrug resistance-associated protein 5	ABCC5	0.0196
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0196
318	Alpha-2A adrenergic receptor	ADRA2A	0.0196
6147	Solute carrier family 22 member 3	SLC22A3	0.0195
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0194
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0193
766	Beta-2 adrenergic receptor	ADRB2	0.0191
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0188
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0187
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0186
444	Alcohol dehydrogenase 1B	ADH1B	0.0184
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0182
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0179
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0179
4311	tRNA	TRDMT1	0.0178
4325	tRNA	trmD	0.0178
4328	tRNA	trmD	0.0178
713	Sodium-dependent dopamine transporter	SLC6A3	0.0176
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0173
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0172
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0167
3426	Glutamine synthetase	glnA	0.0167
3987	Glutamine synthetase	GLUL	0.0167
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0165
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0161
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.016
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.016
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0159
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0158
705	Glutamate receptor 1	GRIA1	0.0158
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0158
899	Glutathione S-transferase Mu 3	GSTM3	0.0156
905	Glutathione transferase omega-1	GSTO1	0.0156
2164	Multidrug resistance-associated protein 4	ABCC4	0.0152
517	Alcohol dehydrogenase 1C	ADH1C	0.0152
820	Glycine receptor subunit alpha-2	GLRA2	0.015
847	Mu-type opioid receptor	OPRM1	0.015
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0149
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0148
3941	Amine oxidase [flavin-containing] A	MAOA	0.0148
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0148
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0148
731	HIV-1 protease	HIV-1 protease	0.0147
613	Atrial natriuretic peptide receptor A	NPR1	0.0146
6142	Solute carrier family 22 member 8	SLC22A8	0.0142
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0142
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0141
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0139
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0138
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0138
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0135
6143	Solute carrier family 22 member 7	SLC22A7	0.0135
275	Arachidonate 5-lipoxygenase	ALOX5	0.0134
6102	Arylamine N-acetyltransferase 2	NAT2	0.0134
833	Organic cation/carnitine transporter 1	SLC22A4	0.0133
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.013
122	P2Y purinoceptor 12	P2RY12	0.0129
23	D(1A) dopamine receptor	DRD1	0.0128
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0127
375	SEC14-like protein 3	SEC14L3	0.0127
86	SEC14-like protein 4	SEC14L4	0.0127
4076	Diacylglycerol kinase alpha	DGKA	0.0127
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0127
569	Retinal dehydrogenase 2	ALDH1A2	0.0127
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0126
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0124
719	Retinoic acid receptor responder protein 1	RARRES1	0.0124
770	Retinoic acid-induced protein 3	GPRC5A	0.0124
632	Alpha-1B adrenergic receptor	ADRA1B	0.0124
1757	Myeloperoxidase	MPO	0.0122
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0122
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0121
1010	Cytochrome P450 51A1	CYP51A1	0.0121
193	Beta-1 adrenergic receptor	ADRB1	0.0121
908	Glutathione S-transferase theta-1	GSTT1	0.0121
3939	Amine oxidase [flavin-containing] B	MAOB	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
997	Protein kinase C beta type	PRKCB	0.0118
611	Retinal dehydrogenase 1	ALDH1A1	0.0118
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0117
467	Delta-type opioid receptor	OPRD1	0.0116
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0116
48	Pyridoxal kinase	PDXK	0.0116
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0114
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0114
232	Corticosteroid-binding globulin	SERPINA6	0.0113
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0112
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0112
2230	Catalase	CAT	0.0111
3249	Catalase	katA	0.0111
3625	Catalase	katA	0.0111
4539	Catalase	katA	0.0111
4941	Catalase	katB	0.0111
1970	Protein kinase C alpha type	PRKCA	0.011
380	Cytochrome P450 17A1	CYP17A1	0.0109
6220	Aryl hydrocarbon receptor	AHR	0.0109
817	DNA topoisomerase 2-alpha	TOP2A	0.0108
708	Alpha-tocopherol transfer protein	TTPA	0.0107
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0106
283	SEC14-like protein 2	SEC14L2	0.0106
16	Adenosine A1 receptor	ADORA1	0.0106
6137	Multidrug resistance-associated protein 6	ABCC6	0.0105
696	Kappa-type opioid receptor	OPRK1	0.0104
790	DNA polymerase subunit alpha B	POLA2	0.0103
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0102
921	Glutamate receptor 2	GRIA2	0.0102
891	Dihydropteroate synthase	folP	0.0102
5359	Dihydropteroate synthase	folP	0.0102
7175	Dihydropteroate synthase	sulI	0.0102
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0102
811	Translocator protein	TSPO	0.01
885	5-hydroxytryptamine 1B receptor	HTR1B	0.01
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0099
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0099
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0099
284	DNA-directed RNA polymerase beta chain	rpoB	0.0098
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0098
2499	Tubulin beta-2C chain	TUBB2C	0.0098
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0098
6146	High affinity copper uptake protein 1	SLC31A1	0.0097
780	Retinoic acid receptor RXR-gamma	RXRG	0.0097
789	Alpha-1D adrenergic receptor	ADRA1D	0.0097
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0097
638	D(3) dopamine receptor	DRD3	0.0097
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0096
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0096
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0096
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0096
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0096
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0096
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0095
869	Estrogen receptor beta	ESR2	0.0094
2449	Tubulin alpha-3 chain	TUBA1A	0.0094
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0091
818	50S ribosomal protein L10	rplJ	0.009
4604	Liver carboxylesterase 1	CES1	0.009
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.009
4237	50S ribosomal protein L22	rplV	0.009
68	Cannabinoid receptor 1	CNR1	0.009
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0089
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0089
469	Annexin A1	ANXA1	0.0088
810	Heme oxygenase 1	HMOX1	0.0087
3391	Heme oxygenase 1	pbsA1	0.0087
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0087
88	Retinoic acid receptor RXR-beta	RXRB	0.0087
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0086
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0086
174	Sigma 1-type opioid receptor	SIGMAR1	0.0085
6020	Aldehyde oxidase	AOX1	0.0085
146	Androgen receptor	AR	0.0085
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0084
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0084
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
844	Epidermal growth factor receptor	EGFR	0.0083
1178	Adenosine A2a receptor	ADORA2A	0.0083
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
6163	Copper-transporting ATPase 2	ATP7B	0.0082
6165	Copper-transporting ATPase 1	ATP7A	0.0082
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0082
716	5-hydroxytryptamine 7 receptor	HTR7	0.008
4120	NADPH--cytochrome P450 reductase	POR	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0079
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0079
6148	Multidrug resistance-associated protein 7	ABCC10	0.0078
614	Progesterone receptor	PGR	0.0078
378	Alpha-2C adrenergic receptor	ADRA2C	0.0078
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0078
1192	Sulfotransferase 1A1	SULT1A1	0.0078
4238	50S ribosomal protein L4	rplD	0.0077
5578	50S ribosomal protein L4	rplD	0.0077
6173	50S ribosomal protein L4	rplD	0.0077
6219	50S ribosomal protein L4	rplD	0.0077
295	Carbonic anhydrase 1	CA1	0.0077
7	Nitric oxide synthase, inducible	NOS2	0.0077
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0076
1517	Beta-3 adrenergic receptor	ADRB3	0.0076
162	Retinoic acid receptor gamma-1	RARG	0.0076
629	Alpha-2B adrenergic receptor	ADRA2B	0.0074
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0073
563	Thyroid peroxidase	TPO	0.0073
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0073
373	Transthyretin	TTR	0.0071
6766	O-GlcNAcase BT_4395	BT_4395	0.0071
94	5-hydroxytryptamine 4 receptor	HTR4	0.007
1024	Solute carrier family 22 member 11	SLC22A11	0.0069
29	Tubulin beta-1 chain	TUBB1	0.0069
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0069
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0069
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0068
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0068
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0066
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0066
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0065
756	Sex hormone-binding globulin	SHBG	0.0065
6182	Cytochrome P450 2J2	CYP2J2	0.0064
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0064
106	Cannabinoid receptor 2	CNR2	0.0064
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0064
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0064
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0063
903	Glutathione S-transferase A5	GSTA5	0.0063
161	Tubulin beta chain	TUBB	0.0062
312	Tubulin beta chain	TUB2	0.0062
504	Mast/stem cell growth factor receptor	KIT	0.0062
814	Ryanodine receptor 1	RYR1	0.0061
592	Carbonic anhydrase 4	CA4	0.006
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.006
2298	Cytochrome P450-cam	camC	0.006
518	Peroxidase/catalase T	katG	0.006
6141	Sodium/bile acid cotransporter	SLC10A1	0.0059
856	Vitamin D3 receptor	VDR	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
4122	Histone deacetylase 2	HDAC2	0.0058
3937	Fatty-acid amide hydrolase	FAAH	0.0057
131	Synaptic vesicular amine transporter	SLC18A2	0.0057
432	D(4) dopamine receptor	DRD4	0.0056
1656	CYP2B protein	CYP2B	0.0055
477	DNA topoisomerase 4 subunit A	parC	0.0055
886	DNA topoisomerase 4 subunit A	parC	0.0055
6226	DNA topoisomerase 4 subunit A	parC	0.0055
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0055
900	Glutathione S-transferase A4	GSTA4	0.0054
3809	Estrogen-related receptor gamma	ESRRG	0.0054
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0054
898	Glutathione S-transferase A3	GSTA3	0.0054
6043	Putative G-protein coupled receptor 44	GPR44	0.0054
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0054
4228	Keratin, type II cytoskeletal 7	KRT7	0.0054
404	DNA gyrase subunit A	gyrA	0.0054
6224	DNA gyrase subunit A	gyrA	0.0054
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0053
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0053
6138	Multidrug resistance protein 3	ABCB4	0.0053
4034	Glutaredoxin-1	GLRX	0.0053
1928	Leukotriene C4 synthase	LTC4S	0.0053
4035	Glutathione S-transferase Mu 5	GSTM5	0.0053
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0053
4040	Glutathione peroxidase 7	GPX7	0.0053
906	Glutathione peroxidase 1	GPX1	0.0053
4036	Glutathione peroxidase 6	GPX6	0.0053
4037	Hypothetical protein	GPX1	0.0053
4297	Hypothetical protein	SP_1951	0.0053
4521	Hypothetical protein	BC_2969	0.0053
4540	Hypothetical protein	TM_1070	0.0053
4555	Hypothetical protein	MT1739	0.0053
4569	Hypothetical protein	mshD	0.0053
4578	Hypothetical protein	PA3270	0.0053
4747	Hypothetical protein	PA3967	0.0053
5177	Hypothetical protein	TM_0096	0.0053
5194	Hypothetical protein	PA1204	0.0053
5240	Hypothetical protein	Rv2991	0.0053
5370	Hypothetical protein	TM_1158	0.0053
5710	Hypothetical protein	Tb927.5.1360	0.0053
4029	Microsomal glutathione S-transferase 3	MGST3	0.0053
4032	Microsomal glutathione S-transferase 1	MGST1	0.0053
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0053
907	Glutathione peroxidase 2	GPX2	0.0053
4038	Glutathione peroxidase 4	GPX4	0.0053
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0053
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0053
910	Epididymal secretory glutathione peroxidase	GPX5	0.0053
911	Glutathione peroxidase 3	GPX3	0.0053
4042	Glutathione transferase omega-2	GSTO2	0.0053
4033	S-formylglutathione hydrolase	ESD	0.0053
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0053
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
1050	Bile salt sulfotransferase	SULT2A1	0.005
823	Fibroblast growth factor receptor 2	FGFR2	0.005
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.005
400	Coagulation factor IX	F9	0.005
5461	Coagulation factor IX	F9	0.005
581	Cytochrome P450 2R1	CYP2R1	0.0049
3810	Catechol O-methyltransferase	COMT	0.0049
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0048
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0048
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0048
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0047
6126	Carbonic anhydrase 7	CA7	0.0047
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
5934	Cytochrome P450 26A1	CYP26A1	0.0046
1714	Mitogen-activated protein kinase 3	MAPK3	0.0046
897	Glutathione S-transferase kappa 1	GSTK1	0.0046
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0046
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0046
604	Vitamin K-dependent protein Z	PROZ	0.0045
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0045
952	Dipeptidyl peptidase 4	DPP4	0.0045
357	Carbonic anhydrase 2	CA2	0.0045
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
4203	Histamine N-methyltransferase	HNMT	0.0044
909	Maleylacetoacetate isomerase	GSTZ1	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0044
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0044
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0044
33	Cystine/glutamate transporter	SLC7A11	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0042
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0042
422	Vitamin K-dependent protein C	PROC	0.0042
1245	Vitamin K-dependent protein S	PROS1	0.0042
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0041
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0041
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0041
6432	Transporter	snf	0.0041
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0041
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0041
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
737	Mineralocorticoid receptor	NR3C2	0.004
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.004
2165	Glutathione S-transferase Mu 2	GSTM2	0.004
473	L-lactate dehydrogenase A chain	LDHA	0.0039
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0039
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
207	Glutathione synthetase	GSS	0.0038
5269	Glutathione synthetase	gshB	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
124	Histamine H2 receptor	HRH2	0.0038
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0038
1275	Estrogen sulfotransferase	SULT1E1	0.0038
2236	Casein kinase II subunit alpha	CSNK2A1	0.0038
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
714	Glutathione reductase, mitochondrial	GSR	0.0038
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0037
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0037
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0037
6174	50S ribosomal protein L32	rpmF	0.0037
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0037
407	Vascular endothelial growth factor receptor 2	KDR	0.0037
901	Glutathione S-transferase Mu 4	GSTM4	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0036
1992	Vitamin D-binding protein	GC	0.0036
427	Substance-P receptor	TACR1	0.0036
1636	Trace amine-associated receptor 1	TAAR1	0.0036
3404	Exotoxin A	eta	0.0036
185	Vasopressin V1a receptor	AVPR1A	0.0035
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0035
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0035
1268	Neuropeptide S receptor	NPSR1	0.0035
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0035
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0035
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0035
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0035
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0035
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
976	Platelet glycoprotein IX	GP9	0.0034
239	Coagulation factor X	F10	0.0034
1629	Transcription factor AP-1	JUN	0.0034
1313	Lactoylglutathione lyase	GLO1	0.0034
798	Osteocalcin	BGLAP	0.0034
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0034
1374	Natriuretic peptides B	NPPB	0.0034
1827	Gap junction alpha-1 protein	GJA1	0.0034
1908	Vascular cell adhesion protein 1	VCAM1	0.0034
26	Vascular endothelial growth factor receptor 3	FLT4	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
474	Acetylcholinesterase	ACHE	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
365	Dihydrofolate reductase	DHFR	0.0032
2381	Dihydrofolate reductase	DFR1	0.0032
2833	Dihydrofolate reductase	Not Available	0.0032
2931	Dihydrofolate reductase	folA	0.0032
3544	Dihydrofolate reductase	folA	0.0032
3682	Dihydrofolate reductase	folA	0.0032
6642	Dihydrofolate reductase	folA	0.0032
6756	Dihydrofolate reductase	dfrA	0.0032
32	Vascular endothelial growth factor receptor 1	FLT1	0.0032
6131	Carbonic anhydrase 14	CA14	0.0032
319	Opioid receptor, sigma 1	OPRS1	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
183	Vascular endothelial growth factor A	VEGFA	0.0032
6073	Potassium channel subfamily K member 9	KCNK9	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
6072	Potassium channel subfamily K member 3	KCNK3	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0031
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0031
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0031
751	Potassium channel subfamily K member 6	KCNK6	0.0031
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0031
369	Coagulation factor VII	F7	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.003
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.003
6122	Carbonic anhydrase 3	CA3	0.003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.003
54	Prothrombin	F2	0.0029
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0029
1569	G1/S-specific cyclin-D1	CCND1	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0028
2290	ADP-ribosyl cyclase 2	BST1	0.0028
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0028
1253	Interferon gamma	IFNG	0.0028
172	Potassium channel subfamily K member 1	KCNK1	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0027
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0027
4192	DNA topoisomerase 2-beta	TOP2B	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
6085	Fatty acid-binding protein, intestinal	FABP2	0.0027
936	Ephrin type-A receptor 2	EPHA2	0.0027
163	D(1B) dopamine receptor	DRD5	0.0027
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0027
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
164	Histamine H4 receptor	HRH4	0.0026
571	Melatonin receptor type 1A	MTNR1A	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
634	Squalene monooxygenase	SQLE	0.0026
7196	Squalene monooxygenase	ERG1	0.0026
1618	High affinity nerve growth factor receptor	NTRK1	0.0026
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0026
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0026
267	Plasminogen activator inhibitor 1	SERPINE1	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
291	Nitric-oxide synthase, endothelial	NOS3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1039	Histone deacetylase 9	HDAC9	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2207	Rhodopsin	RHO	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0024
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4217	Telomerase reverse transcriptase	TERT	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0023
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0023
6221	Steroid hormone receptor ERR1	ESRRA	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
1262	Corticotropin-lipotropin	POMC	0.0023
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0022
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0022
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
65	Matrix metalloproteinase-9	Not Available	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
3007	Carbonic anhydrase 12	CA12	0.0021
4205	Carbonic anhydrase 9	CA9	0.0021
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0021
822	Aldose reductase	AKR1B1	0.0021
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0021
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0021
3601	Dihydropteroate synthase 1	folP1	0.0021
3807	Dihydropteroate synthase 1	folP1	0.0021
3808	Dihydropteroate synthase 2	folP2	0.0021
4103	Proteasome subunit beta type 2	PSMB2	0.002
4102	Proteasome subunit beta type 5	PSMB5	0.002
4101	Proteasome subunit beta type 1	PSMB1	0.002
627	11-cis retinol dehydrogenase	RDH5	0.002
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.002
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.002
738	Monocarboxylate transporter 1	SLC16A1	0.002
4226	Uridine phosphorylase 2	UPP2	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
2408	Tyrosine-protein kinase SYK	SYK	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0019
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0019
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0019
3957	Adenosine deaminase	ADA	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0019
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0019
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0019
3830	Calreticulin	CALR	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
24	Thymidylate synthase	TMP1	0.0018
359	Thymidylate synthase	TYMS	0.0018
2626	Thymidylate synthase	thyA	0.0018
2729	Thymidylate synthase	thyA	0.0018
5352	Thymidylate synthase	THYA	0.0018
683	Potassium transporter	GK0582	0.0018
4225	Uridine phosphorylase 1	UPP1	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0018
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0018
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0018
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
6034	Hydroxyindole O-methyltransferase	ASMT	0.0017
6035	Nuclear receptor ROR-beta	RORB	0.0017
6036	Eosinophil peroxidase	EPX	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
1630	Integrin beta-2	ITGB2	0.0017
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
165	FL cytokine receptor	FLT3	0.0017
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0017
413	Amidophosphoribosyltransferase	PPAT	0.0017
2515	Amidophosphoribosyltransferase	purF	0.0017
3714	Amidophosphoribosyltransferase	purF	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0016
735	Alanine aminotransferase 1	GPT	0.0016
3904	Alanine aminotransferase 2	GPT2	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0015
765	Indoleamine 2,3-dioxygenase	IDO1	0.0015
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3639	Thymidine phosphorylase	deoA	0.0014
3936	Thymidine phosphorylase	TYMP	0.0014
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
5798	Mitogen-activated protein kinase 11	MAPK11	0.0013
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0012
1295	Fatty acid synthase	FASN	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
816	Biliverdin reductase A	BLVRA	0.0011
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0011
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0011
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3221	Cytochrome c4	cc4	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0011
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0011
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0011
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0011
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0011
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0011
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0011
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0011
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0011
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0011
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0011
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0011
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0011
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0011
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0011
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0011
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0011
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0011
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0011
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0011
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0011
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0011
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0011
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0011
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0011
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0011
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0011
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.001
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.001
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.001
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.001
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.001
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.001
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.001
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.001
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.001
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.001
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.001
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.001
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.001
644	Heme oxygenase 2	HMOX2	0.001
4982	Heme oxygenase 2	pbsA2	0.001
729	GDP-L-fucose synthetase	TSTA3	0.001
3463	GDP-L-fucose synthetase	fcl	0.001
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.001
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.001
167	L-lactate dehydrogenase C chain	LDHC	0.001
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.001
206	3-keto-steroid reductase	HSD17B7	0.001
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.001
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.001
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.001
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.001
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.001
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.001
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.001
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.001
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.001
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.001
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.001
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.001
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.001
34	7-dehydrocholesterol reductase	DHCR7	0.001
711	UDP-glucose 6-dehydrogenase	UGDH	0.001
3672	UDP-glucose 6-dehydrogenase	hasB	0.001
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.001
107	C-4 methylsterol oxidase	SC4MOL	0.001
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.001
3726	D-3-phosphoglycerate dehydrogenase	serA	0.001
4291	D-3-phosphoglycerate dehydrogenase	serA	0.001
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.001
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.001
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.001
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.001
643	Peroxisomal bifunctional enzyme	EHHADH	0.001
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.001
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.001
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
345	Plasma retinol-binding protein	RBP4	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.001
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.001
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.001
646	Malate dehydrogenase, cytoplasmic	MDH1	0.001
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.001
328	Sorbitol dehydrogenase	SORD	0.001
396	Alcohol dehydrogenase 4	ADH4	0.001
597	Dihydropteridine reductase	QDPR	0.001
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.001
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0009
666	NADP-dependent malic enzyme	ME1	0.0009
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
6026	Alcohol dehydrogenase 6	ADH6	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0009
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0009
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0009
857	Malate dehydrogenase, mitochondrial	MDH2	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
626	Cysteine dioxygenase type 1	CDO1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
12	Alcohol dehydrogenase class 3	ADH5	0.0009
77	L-lactate dehydrogenase B chain	LDHB	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0008
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0008
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0008
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0008
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0008
13	Aminomethyltransferase, mitochondrial	AMT	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6459	Glycodelin	PAEP	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
1593	Mucin-2	MUC2	0.0008
279	Tyrosinase	TYR	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0008
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0007
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2802	Endoglucanase G	celCCG	0.0007
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
654	Flavin reductase	BLVRB	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
273	Apoptosis regulator Bcl-2	BCL2	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4943	Cytochrome c6	petJ	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4909	CooA protein	cooA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
5000	HemO	hemO	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4972	P450cin	cinA	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4961	Hemophore HasA	hasA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
4952	Catalase/peroxidase	katA	0.0004
3093	Catalase HPII	katE	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
572	Integrin alpha-L	ITGAL	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0003
4920	Peroxidase/catalase	katG	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4990	PpcA	ppcA	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
1507	Cytochrome c	CYCS	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00636 - Clofibrate

Targets

Enzymes

Predictions