DT-Web

DB01307 - Insulin Detemir


Identification
Name Insulin Detemir
Accession Number DB01307
Type biotech
Description Insulin detemir is a long-acting human insulin analogue used to maintain basal levels of insulin in diabetic individuals. It is produced using recombinant DNA technology in yeast cells. This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side chain increases self-association and albumin binding. This along with slow systemic absorption from the injection site prolongs distribution of the hormone into tissues and results in a long duration of action. Novo Nordisk markets insulin detemir under the trade name Levemir.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 5916.9 Daltons
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of type 1 or 2 diabetes mellitus. May be used in combination with oral anti-diabetic agents in type 2 diabetic patients who are not in adequate metabolic control with oral anti-diabetic agents alone.
Mechanism of action Insulin detemir binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism and catabolism. Insulin detemir's long duration of action appears to be a result of slow systemic absorption from the injection site and delayed distribution to target tissues. The myristic acid side chain on insulin detemir increases self-association and gives it a high binding affinity to serum albumin. These features slows its distribution into target tissues and prolongs its duration of action.
Absorption Maximum serum concentrations are reached 6 to 8 hours following subcutaneous injection. When single dose of 0.5 units/kg of insulin detemir was given to adult type 1 diabetes patients, the maximum serum concentration (Cmax) was 4,641 ? 2,299 pmol/L. Absorption is also dependent on the site of injection. When injected into the thigh, the AUC was lower than when injected into the deltoid and abdominal regions. Bioavailability is approximately 60%.
Protein binding > 98% bound to albumin
Biotransformation As with natural insulin, all metabolites formed are inactive.
Route of elimination Not Available
Toxicity Hypoglycemia may occur with inappropriately high doses. Neurogenic (autonomic) signs and symptoms of hypoglycemia include trembling, palpitations, sweating, anxiety, hunger, nausea and tingling. Neuroglycopenic signs and symptoms of hypoglycemia include difficulty concentrating, lethargy/weakness, confusion, drowsiness, vision changes, difficulty speaking, headache, and dizziness. Mild hypoglycemia is characterized by the presence of autonomic symptoms. Moderate hypoglycemia is characterized by the presence of autonomic and neuroglycopenic symptoms. Individuals may become unconscious in severe cases of hypoglycemia. Injection site reactions may also occur. Symptoms include: redness, inflammation, bruising, swelling and itching at the injection site.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol The beta-blocker, acebutolol, may decrease symptoms of hypoglycemia.
Atenolol The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Bisoprolol The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Carvedilol The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Clofibrate Increases the effect of insulin
Dexfenfluramine Fenfluramine increases the effect of insulin
Esmolol The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Fenfluramine Fenfluramine increases the effect of insulin
Somatropin recombinant Somatropin may antagonize the hypoglycemic effect of insulin detemir. Monitor for changes in fasting and postprandial blood sugars.
Food Interactions Not Available

Targets


Insulin receptor
Name Insulin receptor
Gene Name INSR
Pharmacological action yes
Actions agonist
References
  • Hennige AM, Sartorius T, Tschritter O, Preissl H, Fritsche A, Ruth P, Haring HU: Tissue selectivity of insulin detemir action in vivo. Diabetologia. 2006 Jun;49(6):1274-82. Epub 2006 Mar 29. - Pubmed
  • Kurtzhals P, Schaffer L, Sorensen A, Kristensen C, Jonassen I, Schmid C, Trub T: Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes. 2000 Jun;49(6):999-1005. - Pubmed
  • Sorensen AR, Stidsen CE, Ribel U, Nishimura E, Sturis J, Jonassen I, Bouman SD, Kurtzhals P, Brand CL: Insulin detemir is a fully efficacious, low affinity agonist at the insulin receptor. Diabetes Obes Metab. 2010 Aug;12(8):665-73. - Pubmed
  • Wada T, Azegami M, Sugiyama M, Tsuneki H, Sasaoka T: Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin. Diabetes Res Clin Pract. 2008 Sep;81(3):269-77. Epub 2008 Jun 27. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7249

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inducer
References
DTHybrid score 0.391

Carriers


Predictions


Id Partner name Gene Name Score
958 Insulin-like growth factor 1 receptor IGF1R 0.1847
4512 Cytochrome P450 3A4 CYP3A4 0.1014
1372 Insulin receptor substrate 1 IRS1 0.0833
4757 Cytochrome P450 2C9 CYP2C9 0.0771
6016 Cytochrome P450 2C19 CYP2C19 0.0647
4119 Cytochrome P450 2D6 CYP2D6 0.0633
1350 Insulin-like growth factor-binding protein 3 IGFBP3 0.0625
1588 Multidrug resistance protein 1 ABCB1 0.057
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0501
1176 Mitogen-activated protein kinase 1 MAPK1 0.0487
4924 Cytochrome P450 2C8 CYP2C8 0.0476
6024 Cytochrome P450 1A1 CYP1A1 0.0432
6030 Cytochrome P450 2B6 CYP2B6 0.038
4118 Cytochrome P450 3A5 CYP3A5 0.0375
6013 Cytochrome P450 2E1 CYP2E1 0.0371
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0352
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.035
3847 Neuroendocrine convertase 2 PCSK2 0.035
2009 Protein NOV homolog NOV 0.0349
3850 Synaptotagmin-like protein 4 SYTL4 0.0349
1949 Carboxypeptidase E CPE 0.0349
3846 Retinoblastoma-associated protein RB1 0.0349
3848 Neuroendocrine convertase 1 PCSK1 0.0349
20 Prostaglandin G/H synthase 1 PTGS1 0.0334
1729 Solute carrier family 22 member 6 SLC22A6 0.0317
2155 Insulin-degrading enzyme IDE 0.0312
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0297
290 Prostaglandin G/H synthase 2 PTGS2 0.027
1243 Cathepsin D CTSD 0.0261
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0244
6107 Cytochrome P450 3A7 CYP3A7 0.0243
5718 Cytochrome P450 2A6 CYP2A6 0.0211
891 Dihydropteroate synthase folP 0.0207
5359 Dihydropteroate synthase folP 0.0207
7175 Dihydropteroate synthase sulI 0.0207
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0193
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0183
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0182
502 5-hydroxytryptamine 2A receptor HTR2A 0.0178
6142 Solute carrier family 22 member 8 SLC22A8 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
2621 Thermoresistant gluconokinase gntK 0.0168
5466 Putative sugar kinase STM4066 0.0167
4517 Probable butyrate kinase 2 buk2 0.0167
2878 Probable serine/threonine-protein kinase pknB pknB 0.0167
6145 Solute carrier family 22 member 1 SLC22A1 0.0167
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0164
831 D(2) dopamine receptor DRD2 0.0156
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0154
5312 Kinesin-like protein KIF1A KIF1A 0.0154
23 D(1A) dopamine receptor DRD1 0.0149
3669 Ribokinase rbsK 0.0146
2615 Chemotaxis protein cheA cheA 0.0146
6541 Peptostreptococcal albumin-binding protein pab 0.0142
2717 Folylpolyglutamate synthase fgs 0.0139
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0139
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0137
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0134
1024 Solute carrier family 22 member 11 SLC22A11 0.0133
556 Alpha-1A adrenergic receptor ADRA1A 0.0133
48 Pyridoxal kinase PDXK 0.0131
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0131
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0131
862 Multidrug resistance-associated protein 1 ABCC1 0.013
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
6143 Solute carrier family 22 member 7 SLC22A7 0.0127
318 Alpha-2A adrenergic receptor ADRA2A 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
492 Histamine H1 receptor HRH1 0.0124
320 5-hydroxytryptamine 1A receptor HTR1A 0.0117
1898 Cytochrome P450 1B1 CYP1B1 0.0115
2164 Multidrug resistance-associated protein 4 ABCC4 0.0114
118 Organic cation/carnitine transporter 2 SLC22A5 0.0112
6106 Cytochrome P450 2C18 CYP2C18 0.011
824 Sodium-dependent serotonin transporter SLC6A4 0.0107
3941 Amine oxidase [flavin-containing] A MAOA 0.0106
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0105
3811 Cytochrome P450 19A1 CYP19A1 0.0103
632 Alpha-1B adrenergic receptor ADRA1B 0.0102
2211 Fatty acid-binding protein, heart FABP3 0.0098
817 DNA topoisomerase 2-alpha TOP2A 0.0096
566 Serotransferrin TF 0.0094
885 5-hydroxytryptamine 1B receptor HTR1B 0.0093
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0093
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0092
590 5-hydroxytryptamine 2C receptor HTR2C 0.0091
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0091
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.009
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0084
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0082
136 Estrogen receptor ESR1 0.0081
725 5-hydroxytryptamine 1D receptor HTR1D 0.0081
6144 Solute carrier family 22 member 2 SLC22A2 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0078
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0077
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0074
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0073
756 Sex hormone-binding globulin SHBG 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
645 Penicillin-binding protein 1A mrcA 0.0071
5805 Penicillin-binding protein 1A ponA 0.0071
6185 Penicillin-binding protein 1A mrcA 0.0071
6799 Penicillin-binding protein 1A pbpA 0.0071
629 Alpha-2B adrenergic receptor ADRA2B 0.0071
537 ATP synthase delta chain, mitochondrial ATP5D 0.007
193 Beta-1 adrenergic receptor ADRB1 0.0068
3923 Cholinesterase BCHE 0.0068
705 Glutamate receptor 1 GRIA1 0.0068
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0067
3939 Amine oxidase [flavin-containing] B MAOB 0.0067
16 Adenosine A1 receptor ADORA1 0.0066
789 Alpha-1D adrenergic receptor ADRA1D 0.0065
341 5-hydroxytryptamine 3 receptor HTR3A 0.0063
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0063
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0061
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
373 Transthyretin TTR 0.006
465 Calmodulin CALM1 0.0059
378 Alpha-2C adrenergic receptor ADRA2C 0.0058
183 Vascular endothelial growth factor A VEGFA 0.0058
638 D(3) dopamine receptor DRD3 0.0056
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0056
844 Epidermal growth factor receptor EGFR 0.0054
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6085 Fatty acid-binding protein, intestinal FABP2 0.0052
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0052
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0051
70 Type-1 angiotensin II receptor AGTR1 0.0051
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.005
103 Muscarinic acetylcholine receptor M1 CHRM1 0.005
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.005
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.005
4604 Liver carboxylesterase 1 CES1 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0049
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0048
776 Bile salt export pump ABCB11 0.0047
6147 Solute carrier family 22 member 3 SLC22A3 0.0047
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
766 Beta-2 adrenergic receptor ADRB2 0.0047
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0047
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
6141 Sodium/bile acid cotransporter SLC10A1 0.0046
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0046
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0045
6220 Aryl hydrocarbon receptor AHR 0.0045
122 P2Y purinoceptor 12 P2RY12 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0044
777 Tumor necrosis factor TNF 0.0044
833 Organic cation/carnitine transporter 1 SLC22A4 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
432 D(4) dopamine receptor DRD4 0.0044
738 Monocarboxylate transporter 1 SLC16A1 0.0043
1517 Beta-3 adrenergic receptor ADRB3 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
468 Cytochrome P450 4A11 CYP4A11 0.0041
273 Apoptosis regulator Bcl-2 BCL2 0.0041
6014 Cytochrome P450 2A13 CYP2A13 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
869 Estrogen receptor beta ESR2 0.004
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.004
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0039
459 Retinoic acid receptor RXR-alpha RXRA 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
847 Mu-type opioid receptor OPRM1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
146 Androgen receptor AR 0.0037
436 5-hydroxytryptamine 2B receptor HTR2B 0.0037
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
6102 Arylamine N-acetyltransferase 2 NAT2 0.0036
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0036
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0036
6043 Putative G-protein coupled receptor 44 GPR44 0.0036
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0036
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0036
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0035
696 Kappa-type opioid receptor OPRK1 0.0035
871 Glucocorticoid receptor NR3C1 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0034
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
1757 Myeloperoxidase MPO 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
3947 Xanthine dehydrogenase/oxidase XDH 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
594 Thyroxine-binding globulin SERPINA7 0.0032
811 Translocator protein TSPO 0.0032
6677 Myelin P2 protein PMP2 0.0032
163 D(1B) dopamine receptor DRD5 0.0032
595 Fibrinogen alpha chain FGA 0.0032
380 Cytochrome P450 17A1 CYP17A1 0.0031
6148 Multidrug resistance-associated protein 7 ABCC10 0.0031
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
818 50S ribosomal protein L10 rplJ 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
758 Thyroid hormone receptor alpha THRA 0.003
1656 CYP2B protein CYP2B 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
731 HIV-1 protease HIV-1 protease 0.0029
6136 Multidrug resistance-associated protein 5 ABCC5 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0028
33 Cystine/glutamate transporter SLC7A11 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1714 Mitogen-activated protein kinase 3 MAPK3 0.0027
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0027
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0027
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0027
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0027
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0027
6432 Transporter snf 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
228 Beta platelet-derived growth factor receptor PDGFRB 0.0026
229 Retinoic acid receptor beta RARB 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
780 Retinoic acid receptor RXR-gamma RXRG 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
1050 Bile salt sulfotransferase SULT2A1 0.0026
730 Retinoic acid receptor alpha RARA 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6149 Solute carrier family 22 member 10 SLC22A10 0.0025
504 Mast/stem cell growth factor receptor KIT 0.0024
6020 Aldehyde oxidase AOX1 0.0024
467 Delta-type opioid receptor OPRD1 0.0024
1867 Major prion protein PRNP 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
88 Retinoic acid receptor RXR-beta RXRB 0.0024
6231 Pepsin A PGA3 0.0024
6070 Nischarin NISCH 0.0024
162 Retinoic acid receptor gamma-1 RARG 0.0024
633 Penicillin-binding proteins 1A/1B pbpA 0.0024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
904 Glutathione S-transferase P GSTP1 0.0023
716 5-hydroxytryptamine 7 receptor HTR7 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
5934 Cytochrome P450 26A1 CYP26A1 0.0023
3957 Adenosine deaminase ADA 0.0023
275 Arachidonate 5-lipoxygenase ALOX5 0.0023
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0022
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
1256 5-hydroxytryptamine 6 receptor HTR6 0.0021
707 72 kDa type IV collagenase MMP2 0.0021
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6031 Cytochrome P450 3A43 CYP3A43 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.002
1820 Beta-nerve growth factor NGF 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
822 Aldose reductase AKR1B1 0.002
1992 Vitamin D-binding protein GC 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
6137 Multidrug resistance-associated protein 6 ABCC6 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
4226 Uridine phosphorylase 2 UPP2 0.0019
124 Histamine H2 receptor HRH2 0.0019
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
614 Progesterone receptor PGR 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0018
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
1648 Elastin ELN 0.0017
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0016
2207 Rhodopsin RHO 0.0016
474 Acetylcholinesterase ACHE 0.0016
427 Substance-P receptor TACR1 0.0016
244 Angiotensin-converting enzyme ACE 0.0016
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0015
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0015
24 Thymidylate synthase TMP1 0.0015
359 Thymidylate synthase TYMS 0.0015
2626 Thymidylate synthase thyA 0.0015
2729 Thymidylate synthase thyA 0.0015
5352 Thymidylate synthase THYA 0.0015
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
1864 RET proto-oncogene RET 0.0015
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0015
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0015
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0015
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0015
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0014
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
518 Peroxidase/catalase T katG 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
6459 Glycodelin PAEP 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0012
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
563 Thyroid peroxidase TPO 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
6228 Nuclear receptor coactivator 1 NCOA1 0.001
2021 Thrombomodulin THBD 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
357 Carbonic anhydrase 2 CA2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
2320 Thymidine kinase, cytosolic TK1 0.0009
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
6182 Cytochrome P450 2J2 CYP2J2 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3830 Calreticulin CALR 0.0008
6218 Pannexin-1 PANX1 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
976 Platelet glycoprotein IX GP9 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
6042 Prostaglandin reductase 2 PTGR2 0.0007
3810 Catechol O-methyltransferase COMT 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
5818 Folate receptor alpha FOLR1 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
1792 Tissue-type plasminogen activator PLAT 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
4120 NADPH--cytochrome P450 reductase POR 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
5961 Insulin INS 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
6755 Poliovirus receptor PVR 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
7 Nitric oxide synthase, inducible NOS2 0.0004
295 Carbonic anhydrase 1 CA1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
164 Histamine H4 receptor HRH4 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
54 Prothrombin F2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0002
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
↑