DT-Web: DB01136

Identification

Name

Carvedilol

Accession Number

DB01136 (APRD00091)

Type

small molecule

Description

Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

406.4742

Groups

approved

Monoisotopic Weight

406.18925733

Pharmacology

Indication

For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

Mechanism of action

Carvedilol is a racemic mixture in which nonselective beta-adrenoreceptor blocking activity is present in the S(-) enantiomer and alpha-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol's beta-adrenergic receptor blocking ability decreases the heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its alpha adrenergic receptor blocking properties. Carvedilol and its metabolite BM-910228 (a less potent beta blocker, but more potent antioxidant) have been shown to restore the inotropic responsiveness to Ca²⁺ in OH^- free radical-treated myocardium. Carvedilol and its metabolites also prevent OH^- radical-induced decrease in sarcoplasmic reticulum Ca²⁺-ATPase activity. Therefore, carvedilol and its metabolites may be beneficial in chronic heart failure by preventing free radical damage.

Absorption

Carvedilol is rapidly and extensively absorbed following oral administration, with an absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism.

Protein binding

98%

Biotransformation

Hepatic. Carvedilol is metabolized primarily by aromatic ring oxidation and glucuronidation. The oxidative metabolites are further metabolized by conjugation via glucuronidation and sulfation. Demethylation and hydroxylation at the phenol ring produce three active metabolites with b-receptor blocking activity. The 4'-hydroxyphenyl metabolite is approximately 13 times more potent than carvedilol for b-blockade.

Route of elimination

Carvedilol is extensively metabolized. Less than 2% of the dose was excreted unchanged in the urine. Carvedilol is metabolized primarily by aromatic ring oxidation and glucuronidation. The oxidative metabolites are further metabolized by conjugation via glucuronidation and sulfation. The metabolites of carvedilol are excreted primarily via the bile into the feces.

Toxicity

Not expected to be toxic following ingestion.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetohexamide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Chlorpropamide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Citalopram	The SSRI, citalopram, may increase the bradycardic effect of the beta-blocker, carvedilol.
Clonidine	Increased hypertension when clonidine stopped
Cyclosporine	Carvedilol may increase the therapeutic and adverse effects of cyclosporine.
Digoxin	Carvedilol may increase the serum levels and effect of digoxin.
Dihydroergotamine	Ischemia with risk of gangrene
Dihydroergotoxine	Ischemia with risk of gangrene
Disopyramide	The beta-blocker, carvedilol, may increase the toxicity of disopyramide.
Epinephrine	Hypertension, then bradycardia
Ergonovine	Ischemia with risk of gangrene
Ergotamine	Ischemia with risk of gangrene
Escitalopram	The SSRI, escitalopram, may increase the bradycardic effect of the beta-blocker, carvedilol.
Etravirine	Carvedilol, when used concomitantly with etravirine (a CYP2C9 inhibitor), may experience an increase in serum concentration. It is recommended to monitor for signs and symptoms of an increased response to carvedilol, such as orthostatic hypotension and bradycardia.
Fenoterol	Antagonism
Fluoxetine	The SSRI, fluoxetine, may increase the bradycardic effect of the beta-blocker, carvedilol.
Formoterol	Antagonism
Gliclazide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Glipizide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Glisoxepide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Glyburide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Glycodiazine	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Ibuprofen	Risk of inhibition of renal prostaglandins
Indomethacin	Risk of inhibition of renal prostaglandins
Insulin Aspart	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Insulin Detemir	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Insulin Glargine	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Insulin Glulisine	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Insulin Lispro	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Isoproterenol	Antagonism
Lidocaine	The beta-blocker, carvedilol, may increase the effect and toxicity of lidocaine.
Methysergide	Ischemia with risk of gangrene
Orciprenaline	Antagonism
Paroxetine	The SSRI, paroxetine, may increase the bradycardic effect of the beta-blocker, carvedilol.
Pipobroman	Antagonism
Pirbuterol	Antagonism
Piroxicam	Risk of inhibition of renal prostaglandins
Prazosin	Risk of hypotension at the beginning of therapy
Procaterol	Antagonism
Repaglinide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Salbutamol	Antagonism
Salmeterol	Antagonism
Sertraline	The SSRI, sertraline, may increase the bradycardic effect of the beta-blocker, carvedilol.
Terazosin	Increased risk of hypotension. Initiate concomitant therapy cautiously.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Carvedilol. Consider alternate therapy or monitor for therapeutic/adverse effects of Carvedilol if Terbinafine is initiated, discontinued or dose changed.
Terbutaline	Antagonism
Tolazamide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Tolbutamide	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Topotecan	The p-glycoprotein inhibitor, Carvedilol, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Verapamil	Increased effect of both drugs

Food Interactions

Take with food, food slows the absorption rate and reduces the incidence of adverse effects (extent of absorption is not affected).

Beta-1 adrenergic receptor
Name	Beta-1 adrenergic receptor
Gene Name	ADRB1
Pharmacological action	yes
Actions	antagonist
References	Nichols AJ, Gellai M, Ruffolo RR Jr: Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol. Fundam Clin Pharmacol. 1991;5(1):25-38. - Pubmed Nichols AJ, Sulpizio AC, Ashton DJ, Hieble JP, Ruffolo RR Jr: In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol. Pharmacology. 1989;39(5):327-36. - Pubmed Nichols AJ, Sulpizio AC, Ashton DJ, Hieble JP, Ruffolo RR Jr: The interaction of the enantiomers of carvedilol with alpha 1- and beta 1-adrenoceptors. Chirality. 1989;1(4):265-70. - Pubmed de Mey C, Breithaupt K, Schloos J, Neugebauer G, Palm D, Belz GG: Dose-effect and pharmacokinetic-pharmacodynamic relationships of the beta 1-adrenergic receptor blocking properties of various doses of carvedilol in healthy humans. Clin Pharmacol Ther. 1994 Mar;55(3):329-37. - Pubmed
DTHybrid score	0.8917
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.5061
NADH dehydrogenase [ubiquinone] 1 subunit C2
Name	NADH dehydrogenase [ubiquinone] 1 subunit C2
Gene Name	NDUFC2
Pharmacological action	unknown
Actions	inhibitor
References	Oliveira PJ, Santos DJ, Moreno AJ: Carvedilol inhibits the exogenous NADH dehydrogenase in rat heart mitochondria. Arch Biochem Biophys. 2000 Feb 15;374(2):279-85. - Pubmed
DTHybrid score	0.2839
Beta-2 adrenergic receptor
Name	Beta-2 adrenergic receptor
Gene Name	ADRB2
Pharmacological action	unknown
Actions	antagonist
References	Irodova NL, Krasnikova TL, Masenko VP, Kochetov AG, Chazova IE: [Carvedilol in treating primary pulmonary hypertension patients: effect on severity of cardiac failure, degree of pulmonary hypertension, concentration of catecholamines in blood plasma and dependence of cyclic AMP synthesis in lymphocytes on beta-adrenergic receptors] Ter Arkh. 2002;74(8):30-4. - Pubmed Maebara C, Ohtani H, Sugahara H, Mine K, Kubo C, Sawada Y: Nightmares and panic disorder associated with carvedilol overdose. Ann Pharmacother. 2002 Nov;36(11):1736-40. - Pubmed Okajima K, Harada N, Uchiba M, Isobe H: Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats. J Pharmacol Exp Ther. 2004 May;309(2):684-91. Epub 2004 Feb 5. - Pubmed Nichols AJ, Gellai M, Ruffolo RR Jr: Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol. Fundam Clin Pharmacol. 1991;5(1):25-38. - Pubmed
DTHybrid score	0.8902
Vascular endothelial growth factor A
Name	Vascular endothelial growth factor A
Gene Name	VEGFA
Pharmacological action	unknown
Actions	other
References	de Boer RA, Siebelink HJ, Tio RA, Boomsma F, van Veldhuisen DJ: Carvedilol increases plasma vascular endothelial growth factor (VEGF) in patients with chronic heart failure. Eur J Heart Fail. 2001 Jun;3(3):331-3. - Pubmed Saijonmaa O, Nyman T, Fyhrquist F: Carvedilol inhibits basal and stimulated ACE production in human endothelial cells. J Cardiovasc Pharmacol. 2004 May;43(5):616-21. - Pubmed Shyu KG, Lu MJ, Chang H, Sun HY, Wang BW, Kuan P: Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure. J Card Fail. 2005 Mar;11(2):152-9. - Pubmed Shyu KG, Liou JY, Wang BW, Fang WJ, Chang H: Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart. J Biomed Sci. 2005;12(2):409-20. - Pubmed
DTHybrid score	0.6327
Natriuretic peptides B
Name	Natriuretic peptides B
Gene Name	NPPB
Pharmacological action	unknown
Actions	other
References	Ohta Y, Watanabe K, Nakazawa M, Yamamoto T, Ma M, Fuse K, Ito M, Hirono S, Tanabe T, Hanawa H, Kato K, Kodama M, Aizawa Y: Carvedilol enhances atrial and brain natriuretic peptide mRNA expression and release in rat heart. J Cardiovasc Pharmacol. 2000;36 Suppl 2:S19-23. - Pubmed Richards AM, Doughty R, Nicholls MG, MacMahon S, Sharpe N, Murphy J, Espiner EA, Frampton C, Yandle TG: Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: prognostic utility and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. Australia-New Zealand Heart Failure Group. J Am Coll Cardiol. 2001 Jun 1;37(7):1781-7. - Pubmed Konishi H, Nishio S, Tsutamoto T, Minouchi T, Yamaji A: Serum carvedilol concentration and its relation to change in plasma brain natriuretic peptide level in the treatment of heart failure: a preliminary study. Int J Clin Pharmacol Ther. 2003 Dec;41(12):578-86. - Pubmed Takeda Y, Fukutomi T, Suzuki S, Yamamoto K, Ogata M, Kondo H, Sugiura M, Shigeyama J, Itoh M: Effects of carvedilol on plasma B-type natriuretic peptide concentration and symptoms in patients with heart failure and preserved ejection fraction. Am J Cardiol. 2004 Aug 15;94(4):448-53. - Pubmed Frantz RP, Olson LJ, Grill D, Moualla SK, Nelson SM, Nobrega TP, Hanna RD, Backes RJ, Mookadam F, Heublein D, Bailey KR, Burnett JC: Carvedilol therapy is associated with a sustained decline in brain natriuretic peptide levels in patients with congestive heart failure. Am Heart J. 2005 Mar;149(3):541-7. - Pubmed
DTHybrid score	0.3828
Gap junction alpha-1 protein
Name	Gap junction alpha-1 protein
Gene Name	GJA1
Pharmacological action	unknown
Actions	other
References	Yeh HI, Lee PY, Su CH, Tian TY, Ko YS, Tsai CH: Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Am J Hypertens. 2006 Feb;19(2):129-35. - Pubmed Fan SY, Ke YN, Zeng YJ, Wang Y, Cheng WL, Yang JR: [Effects and the mechanism of carvedilol on gap junctional intercellular communication in rat myocardium] Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1141-5. - Pubmed
DTHybrid score	0.3825
Potassium voltage-gated channel subfamily H member 2
Name	Potassium voltage-gated channel subfamily H member 2
Gene Name	KCNH2
Pharmacological action	unknown
Actions	inhibitor
References	Karle CA, Kreye VA, Thomas D, Rockl K, Kathofer S, Zhang W, Kiehn J: Antiarrhythmic drug carvedilol inhibits HERG potassium channels. Cardiovasc Res. 2001 Feb 1;49(2):361-70. - Pubmed Kawakami K, Nagatomo T, Abe H, Kikuchi K, Takemasa H, Anson BD, Delisle BP, January CT, Nakashima Y: Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. - Pubmed
DTHybrid score	0.3718
Vascular cell adhesion protein 1
Name	Vascular cell adhesion protein 1
Gene Name	VCAM1
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Chen JW, Lin FY, Chen YH, Wu TC, Chen YL, Lin SJ: Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2075-81. Epub 2004 Sep 16. - Pubmed
DTHybrid score	0.3825

Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Actions	Not Available
References	- Yue TL, McKenna PJ, Gu JL, Cheng HY, Ruffolo RE Jr, Feuerstein GZ: Carvedilol, a new vasodilating beta adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils. Cardiovasc Res. 1994 Mar;28(3):400-6. - Pubmed
DTHybrid score	0.5504
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6096
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7699
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6567
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8475
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4171
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4367
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5644

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. - Pubmed Jonsson O, Behnam-Motlagh P, Persson M, Henriksson R, Grankvist K: Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity. Biochem Pharmacol. 1999 Dec 1;58(11):1801-6. - Pubmed Neuhoff S, Langguth P, Dressler C, Andersson TB, Regardh CG, Spahn-Langguth H: Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites. Int J Clin Pharmacol Ther. 2000 Apr;38(4):168-79. - Pubmed Hokama N, Hobara N, Sakai M, Kameya H, Ohshiro S, Sakanashi M: Influence of nicardipine and nifedipine on plasma carvedilol disposition after oral administration in rats. J Pharm Pharmacol. 2002 Jun;54(6):821-5. - Pubmed Kakumoto M, Sakaeda T, Takara K, Nakamura T, Kita T, Yagami T, Kobayashi H, Okamura N, Okumura K: Effects of carvedilol on MDR1-mediated multidrug resistance: comparison with verapamil. Cancer Sci. 2003 Jan;94(1):81-6. - Pubmed Brodde OE, Kroemer HK: Drug-drug interactions of beta-adrenoceptor blockers. Arzneimittelforschung. 2003;53(12):814-22. - Pubmed
DTHybrid score	0.5999

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.3838
4924	Cytochrome P450 2C8	CYP2C8	0.2937
4118	Cytochrome P450 3A5	CYP3A5	0.2522
6030	Cytochrome P450 2B6	CYP2B6	0.2024
290	Prostaglandin G/H synthase 2	PTGS2	0.2024
6107	Cytochrome P450 3A7	CYP3A7	0.1815
318	Alpha-2A adrenergic receptor	ADRA2A	0.1605
632	Alpha-1B adrenergic receptor	ADRA1B	0.159
5718	Cytochrome P450 2A6	CYP2A6	0.1525
1517	Beta-3 adrenergic receptor	ADRB3	0.151
587	Serum albumin	ALB	0.1452
5377	Placenta growth factor	PGF	0.1355
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1238
492	Histamine H1 receptor	HRH1	0.1162
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1147
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.1133
320	5-hydroxytryptamine 1A receptor	HTR1A	0.1108
831	D(2) dopamine receptor	DRD2	0.1097
789	Alpha-1D adrenergic receptor	ADRA1D	0.1086
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1029
824	Sodium-dependent serotonin transporter	SLC6A4	0.0925
1898	Cytochrome P450 1B1	CYP1B1	0.0923
6145	Solute carrier family 22 member 1	SLC22A1	0.0917
6144	Solute carrier family 22 member 2	SLC22A2	0.0912
1729	Solute carrier family 22 member 6	SLC22A6	0.083
23	D(1A) dopamine receptor	DRD1	0.0771
3923	Cholinesterase	BCHE	0.0738
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0731
862	Multidrug resistance-associated protein 1	ABCC1	0.0704
629	Alpha-2B adrenergic receptor	ADRA2B	0.0673
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0662
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0649
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0641
6142	Solute carrier family 22 member 8	SLC22A8	0.0613
3811	Cytochrome P450 19A1	CYP19A1	0.0607
6106	Cytochrome P450 2C18	CYP2C18	0.0598
3941	Amine oxidase [flavin-containing] A	MAOA	0.0586
378	Alpha-2C adrenergic receptor	ADRA2C	0.0583
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0581
713	Sodium-dependent dopamine transporter	SLC6A3	0.0576
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.057
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0565
118	Organic cation/carnitine transporter 2	SLC22A5	0.0537
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0519
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0515
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0512
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0509
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0506
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0489
817	DNA topoisomerase 2-alpha	TOP2A	0.0489
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0474
776	Bile salt export pump	ABCB11	0.0471
1334	Tissue factor pathway inhibitor	TFPI	0.0471
465	Calmodulin	CALM1	0.0468
6143	Solute carrier family 22 member 7	SLC22A7	0.0458
6020	Aldehyde oxidase	AOX1	0.0433
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0431
275	Arachidonate 5-lipoxygenase	ALOX5	0.0422
6147	Solute carrier family 22 member 3	SLC22A3	0.0422
450	Muscarinic acetylcholine receptor M4	CHRM4	0.042
1719	Heparanase	HPSE	0.0414
638	D(3) dopamine receptor	DRD3	0.0409
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0406
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0406
136	Estrogen receptor	ESR1	0.0405
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0397
833	Organic cation/carnitine transporter 1	SLC22A4	0.0392
2164	Multidrug resistance-associated protein 4	ABCC4	0.0391
2058	P-selectin	SELP	0.0373
131	Synaptic vesicular amine transporter	SLC18A2	0.0371
777	Tumor necrosis factor	TNF	0.037
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.037
871	Glucocorticoid receptor	NR3C1	0.0359
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0354
468	Cytochrome P450 4A11	CYP4A11	0.0346
1757	Myeloperoxidase	MPO	0.0343
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.034
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0336
233	Potassium channel subfamily K member 2	KCNK2	0.0326
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0325
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0321
260	Cytochrome P450 51	ERG11	0.0319
761	Cytochrome P450 51	ERG11	0.0319
3163	Cytochrome P450 51	cyp51	0.0319
847	Mu-type opioid receptor	OPRM1	0.0317
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0317
432	D(4) dopamine receptor	DRD4	0.0317
3939	Amine oxidase [flavin-containing] B	MAOB	0.0316
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0315
6182	Cytochrome P450 2J2	CYP2J2	0.0312
3810	Catechol O-methyltransferase	COMT	0.0308
309	Antithrombin-III	SERPINC1	0.0307
1024	Solute carrier family 22 member 11	SLC22A11	0.03
844	Epidermal growth factor receptor	EGFR	0.0296
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0295
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0288
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0284
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0279
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0278
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0273
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0272
731	HIV-1 protease	HIV-1 protease	0.0271
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.027
467	Delta-type opioid receptor	OPRD1	0.0268
2300	Lysozyme	E	0.0264
3633	Lysozyme	R	0.0264
5597	Lysozyme	17	0.0264
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0263
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.026
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.026
36	Insulin receptor	INSR	0.0258
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0256
696	Kappa-type opioid receptor	OPRK1	0.025
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0249
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0248
716	5-hydroxytryptamine 7 receptor	HTR7	0.0247
1507	Cytochrome c	CYCS	0.024
6148	Multidrug resistance-associated protein 7	ABCC10	0.0234
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.023
1820	Beta-nerve growth factor	NGF	0.023
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0227
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0221
6137	Multidrug resistance-associated protein 6	ABCC6	0.022
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0219
1656	CYP2B protein	CYP2B	0.0217
828	Phenylalanine-4-hydroxylase	PAH	0.0215
3109	Phenylalanine-4-hydroxylase	phhA	0.0215
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0213
6014	Cytochrome P450 2A13	CYP2A13	0.021
5787	Angiopoietin-1 receptor	TEK	0.021
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.021
122	P2Y purinoceptor 12	P2RY12	0.0206
3932	Glutathione S-transferase A2	GSTA2	0.0203
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0202
3823	Cytokine receptor common gamma chain	IL2RG	0.0202
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0202
4604	Liver carboxylesterase 1	CES1	0.0201
896	Glutathione S-transferase Mu 1	GSTM1	0.0199
4120	NADPH--cytochrome P450 reductase	POR	0.0198
477	DNA topoisomerase 4 subunit A	parC	0.0198
886	DNA topoisomerase 4 subunit A	parC	0.0198
6226	DNA topoisomerase 4 subunit A	parC	0.0198
4411	DNA protection during starvation protein	dps	0.0197
5423	UPF0010 protein HI1317	HI_1317	0.0197
3780	Lipoprotein nlpI precursor	nlpI	0.0197
5424	Endonuclease VIII-like 1	NEIL1	0.0197
163	D(1B) dopamine receptor	DRD5	0.0196
6136	Multidrug resistance-associated protein 5	ABCC5	0.0196
16	Adenosine A1 receptor	ADORA1	0.0196
404	DNA gyrase subunit A	gyrA	0.0195
6224	DNA gyrase subunit A	gyrA	0.0195
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0193
6031	Cytochrome P450 3A43	CYP3A43	0.0192
124	Histamine H2 receptor	HRH2	0.0192
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.019
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.019
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0189
70	Type-1 angiotensin II receptor	AGTR1	0.0188
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0188
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0187
63	Malate dehydrogenase	mdh	0.0186
2329	Malate dehydrogenase	mdh	0.0186
3445	Malate dehydrogenase	mdh	0.0186
4420	Malate dehydrogenase	mdh	0.0186
4438	Malate dehydrogenase	mdh	0.0186
474	Acetylcholinesterase	ACHE	0.0184
891	Dihydropteroate synthase	folP	0.0184
5359	Dihydropteroate synthase	folP	0.0184
7175	Dihydropteroate synthase	sulI	0.0184
373	Transthyretin	TTR	0.0182
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0181
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
1178	Adenosine A2a receptor	ADORA2A	0.0178
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0178
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0177
3221	Cytochrome c4	cc4	0.0177
724	Interleukin-2 receptor alpha chain	IL2RA	0.0176
717	Interleukin-2 receptor subunit beta	IL2RB	0.0176
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0176
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0174
327	Glutathione reductase	gor	0.0174
5110	Glutathione reductase	GR2	0.0174
6102	Arylamine N-acetyltransferase 2	NAT2	0.0173
3164	Biotin synthase	bioB	0.0173
1405	Thiopurine S-methyltransferase	TPMT	0.0172
3186	Soluble calcium-activated nucleotidase 1	CANT1	0.0172
94	5-hydroxytryptamine 4 receptor	HTR4	0.0172
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0171
5036	Small inducible cytokine A8	CCL8	0.017
5012	Ig lambda chain V-II region MGC	Not Available	0.017
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.017
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0168
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0168
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0167
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0166
6146	High affinity copper uptake protein 1	SLC31A1	0.0166
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0165
751	Potassium channel subfamily K member 6	KCNK6	0.0165
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0165
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0162
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0162
6220	Aryl hydrocarbon receptor	AHR	0.0161
380	Cytochrome P450 17A1	CYP17A1	0.0159
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0159
146	Androgen receptor	AR	0.0159
3583	6-phosphogluconolactonase	pgl	0.0159
811	Translocator protein	TSPO	0.0158
723	Cytosolic phospholipase A2	PLA2G4A	0.0154
65	Matrix metalloproteinase-9	Not Available	0.0153
6859	Protein S100-A4	S100A4	0.0152
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0151
3259	Autolysin	lytA	0.0151
172	Potassium channel subfamily K member 1	KCNK1	0.015
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.015
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.015
5023	Glycoside hydrolase	Not Available	0.0148
5024	Glycoside hydrolase	Not Available	0.0148
2449	Tubulin alpha-3 chain	TUBA1A	0.0148
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0148
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0148
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0148
5006	RNASE4 protein	RNASE4	0.0148
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0146
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0146
1654	Interleukin-1 beta	IL1B	0.0145
904	Glutathione S-transferase P	GSTP1	0.0145
2499	Tubulin beta-2C chain	TUBB2C	0.0144
3086	Plasmepsin-2	Not Available	0.0143
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0142
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0142
140	30S ribosomal protein S9	rpsI	0.0141
6719	30S ribosomal protein S9	rpsI	0.0141
6725	30S ribosomal protein S9	rpsI	0.0141
3814	Complement C1r subcomponent	C1R	0.014
908	Glutathione S-transferase theta-1	GSTT1	0.0138
614	Progesterone receptor	PGR	0.0138
1010	Cytochrome P450 51A1	CYP51A1	0.0138
3817	Complement C1q subcomponent subunit C	C1QC	0.0138
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0138
1192	Sulfotransferase 1A1	SULT1A1	0.0138
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0138
3816	Complement C1q subcomponent subunit B	C1QB	0.0138
3815	Complement C1q subcomponent subunit A	C1QA	0.0138
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0137
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0137
494	Caspase-1	CASP1	0.0136
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0136
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0136
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0136
504	Mast/stem cell growth factor receptor	KIT	0.0136
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0136
2149	Angiogenin	ANG	0.0136
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0136
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0135
482	Glycine receptor subunit alpha-1	GLRA1	0.0133
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0133
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0132
869	Estrogen receptor beta	ESR2	0.0132
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0131
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.013
1176	Mitogen-activated protein kinase 1	MAPK1	0.013
790	DNA polymerase subunit alpha B	POLA2	0.0129
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0128
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0126
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0126
3030	Salivary alpha-amylase	AMY1A	0.0126
6141	Sodium/bile acid cotransporter	SLC10A1	0.0125
22	30S ribosomal protein S4	rpsD	0.0125
6714	30S ribosomal protein S4	rpsD	0.0125
365	Dihydrofolate reductase	DHFR	0.0125
2381	Dihydrofolate reductase	DFR1	0.0125
2833	Dihydrofolate reductase	Not Available	0.0125
2931	Dihydrofolate reductase	folA	0.0125
3544	Dihydrofolate reductase	folA	0.0125
3682	Dihydrofolate reductase	folA	0.0125
6642	Dihydrofolate reductase	folA	0.0125
6756	Dihydrofolate reductase	dfrA	0.0125
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0124
4292	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase	lpxA	0.0124
3076	Antigen 85-C	fbpC	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0121
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
2723	Cholera enterotoxin subunit B	ctxB	0.012
6163	Copper-transporting ATPase 2	ATP7B	0.0119
161	Tubulin beta chain	TUBB	0.0119
312	Tubulin beta chain	TUB2	0.0119
6165	Copper-transporting ATPase 1	ATP7A	0.0119
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0119
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0118
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0117
2430	Chondroitinase B	cslB	0.0117
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0117
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0116
2077	Caspase-3	CASP3	0.0116
48	Pyridoxal kinase	PDXK	0.0116
6374	Disintegrin and metalloproteinase domain-containing protein 28	ADAM28	0.0116
818	50S ribosomal protein L10	rplJ	0.0115
7	Nitric oxide synthase, inducible	NOS2	0.0115
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0115
6138	Multidrug resistance protein 3	ABCB4	0.0114
4122	Histone deacetylase 2	HDAC2	0.0114
295	Carbonic anhydrase 1	CA1	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0113
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0113
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0113
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0112
738	Monocarboxylate transporter 1	SLC16A1	0.011
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.011
1629	Transcription factor AP-1	JUN	0.011
251	Alcohol dehydrogenase 1A	ADH1A	0.0109
303	Diamine acetyltransferase 2	SAT2	0.0109
623	Spermine oxidase	SMOX	0.0109
1317	Spermine synthase	SMS	0.0109
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0109
4031	Glutathione S-transferase A1	GSTA1	0.0108
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0107
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0107
444	Alcohol dehydrogenase 1B	ADH1B	0.0107
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0107
185	Vasopressin V1a receptor	AVPR1A	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0106
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0106
6766	O-GlcNAcase BT_4395	BT_4395	0.0105
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0105
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0105
6043	Putative G-protein coupled receptor 44	GPR44	0.0105
6432	Transporter	snf	0.0104
571	Melatonin receptor type 1A	MTNR1A	0.0104
362	Melatonin receptor type 1B	MTNR1B	0.0104
322	Vasopressin V2 receptor	AVPR2	0.0104
232	Corticosteroid-binding globulin	SERPINA6	0.0103
68	Cannabinoid receptor 1	CNR1	0.0103
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0102
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0102
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0102
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0102
952	Dipeptidyl peptidase 4	DPP4	0.0102
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0102
592	Carbonic anhydrase 4	CA4	0.0101
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0101
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
4513	Pancreatic alpha-amylase	AMY2A	0.01
407	Vascular endothelial growth factor receptor 2	KDR	0.01
123	Diamine acetyltransferase 1	SAT1	0.01
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0099
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0099
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0099
756	Sex hormone-binding globulin	SHBG	0.0099
705	Glutamate receptor 1	GRIA1	0.0098
823	Fibroblast growth factor receptor 2	FGFR2	0.0098
6085	Fatty acid-binding protein, intestinal	FABP2	0.0098
4192	DNA topoisomerase 2-beta	TOP2B	0.0097
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0097
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0097
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0096
6847	Lactase-phlorizin hydrolase	LCT	0.0096
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0096
4203	Histamine N-methyltransferase	HNMT	0.0095
6168	Solute carrier family 22 member 16	SLC22A16	0.0094
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0093
427	Substance-P receptor	TACR1	0.0092
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0092
2112	Toll-like receptor 9	TLR9	0.0092
29	Tubulin beta-1 chain	TUBB1	0.0091
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
400	Coagulation factor IX	F9	0.0088
5461	Coagulation factor IX	F9	0.0088
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
33	Cystine/glutamate transporter	SLC7A11	0.0087
814	Ryanodine receptor 1	RYR1	0.0087
26	Vascular endothelial growth factor receptor 3	FLT4	0.0086
3312	Fatty acid-binding protein, brain	FABP7	0.0086
1714	Mitogen-activated protein kinase 3	MAPK3	0.0086
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0085
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0085
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0085
1275	Estrogen sulfotransferase	SULT1E1	0.0085
517	Alcohol dehydrogenase 1C	ADH1C	0.0085
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0084
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0084
239	Coagulation factor X	F10	0.0084
473	L-lactate dehydrogenase A chain	LDHA	0.0084
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0083
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0083
32	Vascular endothelial growth factor receptor 1	FLT1	0.0083
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0083
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0083
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0082
4103	Proteasome subunit beta type 2	PSMB2	0.0081
4102	Proteasome subunit beta type 5	PSMB5	0.0081
4101	Proteasome subunit beta type 1	PSMB1	0.0081
6126	Carbonic anhydrase 7	CA7	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.008
604	Vitamin K-dependent protein Z	PROZ	0.008
714	Glutathione reductase, mitochondrial	GSR	0.008
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0079
54	Prothrombin	F2	0.0079
173	Toll-like receptor 7	TLR7	0.0079
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0078
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0078
449	Ornithine decarboxylase	ODC1	0.0078
106	Cannabinoid receptor 2	CNR2	0.0078
6171	Solute carrier family 28 member 3	SLC28A3	0.0077
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0077
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0077
3426	Glutamine synthetase	glnA	0.0076
3987	Glutamine synthetase	GLUL	0.0076
1050	Bile salt sulfotransferase	SULT2A1	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
634	Squalene monooxygenase	SQLE	0.0076
7196	Squalene monooxygenase	ERG1	0.0076
1648	Elastin	ELN	0.0076
820	Glycine receptor subunit alpha-2	GLRA2	0.0076
357	Carbonic anhydrase 2	CA2	0.0076
921	Glutamate receptor 2	GRIA2	0.0075
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0075
737	Mineralocorticoid receptor	NR3C2	0.0075
569	Retinal dehydrogenase 2	ALDH1A2	0.0075
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0074
422	Vitamin K-dependent protein C	PROC	0.0074
1245	Vitamin K-dependent protein S	PROS1	0.0074
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0073
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0073
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0073
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0072
130	Prostacyclin synthase	PTGIS	0.0072
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0071
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0071
1636	Trace amine-associated receptor 1	TAAR1	0.0071
273	Apoptosis regulator Bcl-2	BCL2	0.0071
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.007
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.007
611	Retinal dehydrogenase 1	ALDH1A1	0.0069
49	Endothelin B receptor	EDNRB	0.0069
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0069
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0069
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0069
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0069
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0069
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0068
4311	tRNA	TRDMT1	0.0068
4325	tRNA	trmD	0.0068
4328	tRNA	trmD	0.0068
1618	High affinity nerve growth factor receptor	NTRK1	0.0067
153	Dopamine beta-hydroxylase	DBH	0.0067
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0067
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0067
459	Retinoic acid receptor RXR-alpha	RXRA	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0065
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0065
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0065
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0064
2236	Casein kinase II subunit alpha	CSNK2A1	0.0064
6151	Monocarboxylate transporter 10	SLC16A10	0.0064
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0063
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
822	Aldose reductase	AKR1B1	0.0063
1353	DNA topoisomerase 1	TOP1	0.0063
3552	DNA topoisomerase 1	topA	0.0063
133	Dihydropterate synthase	sulI	0.0063
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0062
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0062
518	Peroxidase/catalase T	katG	0.0062
976	Platelet glycoprotein IX	GP9	0.0062
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0061
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0061
284	DNA-directed RNA polymerase beta chain	rpoB	0.0061
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0061
780	Retinoic acid receptor RXR-gamma	RXRG	0.0061
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0061
798	Osteocalcin	BGLAP	0.006
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.006
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.006
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.006
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.006
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.006
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.006
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.006
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.006
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.006
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.006
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.006
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0059
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0059
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0059
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0059
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0059
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0059
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0059
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0059
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0059
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0059
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0059
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0059
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0059
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0059
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0059
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0059
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0059
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0059
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0059
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0059
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0059
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0059
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0059
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0059
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0059
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0059
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0059
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0059
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0059
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0059
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0059
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0059
711	UDP-glucose 6-dehydrogenase	UGDH	0.0059
3672	UDP-glucose 6-dehydrogenase	hasB	0.0059
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0059
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0059
107	C-4 methylsterol oxidase	SC4MOL	0.0059
644	Heme oxygenase 2	HMOX2	0.0059
4982	Heme oxygenase 2	pbsA2	0.0059
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0059
729	GDP-L-fucose synthetase	TSTA3	0.0059
3463	GDP-L-fucose synthetase	fcl	0.0059
167	L-lactate dehydrogenase C chain	LDHC	0.0059
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0059
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0059
206	3-keto-steroid reductase	HSD17B7	0.0059
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0059
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0059
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0059
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0059
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0059
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0059
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0059
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0059
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0059
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0059
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0059
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0059
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0059
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0059
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0059
34	7-dehydrocholesterol reductase	DHCR7	0.0059
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0059
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0059
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0059
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0059
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0059
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0059
643	Peroxisomal bifunctional enzyme	EHHADH	0.0059
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0059
856	Vitamin D3 receptor	VDR	0.0059
816	Biliverdin reductase A	BLVRA	0.0059
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0059
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0059
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0059
24	Thymidylate synthase	TMP1	0.0058
359	Thymidylate synthase	TYMS	0.0058
2626	Thymidylate synthase	thyA	0.0058
2729	Thymidylate synthase	thyA	0.0058
5352	Thymidylate synthase	THYA	0.0058
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
3957	Adenosine deaminase	ADA	0.0058
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0058
291	Nitric-oxide synthase, endothelial	NOS3	0.0058
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0058
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0057
627	11-cis retinol dehydrogenase	RDH5	0.0057
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0057
703	NADPH azoreductase	azr	0.0056
319	Opioid receptor, sigma 1	OPRS1	0.0056
88	Retinoic acid receptor RXR-beta	RXRB	0.0055
563	Thyroid peroxidase	TPO	0.0055
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0055
6506	Stathmin-4	STMN4	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
369	Coagulation factor VII	F7	0.0054
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0054
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0054
551	Carnitine O-acetyltransferase	CRAT	0.0054
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0054
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0054
164	Histamine H4 receptor	HRH4	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
6149	Solute carrier family 22 member 10	SLC22A10	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0052
712	Tubulin alpha chain	TUB1	0.0052
84	Nuclear receptor 0B1	NR0B1	0.0051
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0051
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0051
6131	Carbonic anhydrase 14	CA14	0.005
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.005
3937	Fatty-acid amide hydrolase	FAAH	0.005
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.005
666	NADP-dependent malic enzyme	ME1	0.005
581	Cytochrome P450 2R1	CYP2R1	0.0049
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0049
558	Solute carrier family 12 member 1	SLC12A1	0.0049
3404	Exotoxin A	eta	0.0049
328	Sorbitol dehydrogenase	SORD	0.0048
597	Dihydropteridine reductase	QDPR	0.0048
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0048
396	Alcohol dehydrogenase 4	ADH4	0.0048
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
6103	Arylamine N-acetyltransferase 1	NAT1	0.0048
3808	Dihydropteroate synthase 2	folP2	0.0048
3601	Dihydropteroate synthase 1	folP1	0.0048
3807	Dihydropteroate synthase 1	folP1	0.0048
6026	Alcohol dehydrogenase 6	ADH6	0.0047
6044	Serum paraoxonase/lactonase 3	PON3	0.0047
2230	Catalase	CAT	0.0047
3249	Catalase	katA	0.0047
3625	Catalase	katA	0.0047
4539	Catalase	katA	0.0047
4941	Catalase	katB	0.0047
174	Sigma 1-type opioid receptor	SIGMAR1	0.0047
3809	Estrogen-related receptor gamma	ESRRG	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1852	Microtubule-associated protein 2	MAP2	0.0046
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0046
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0046
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0046
268	Adenosine A2b receptor	ADORA2B	0.0046
857	Malate dehydrogenase, mitochondrial	MDH2	0.0046
626	Cysteine dioxygenase type 1	CDO1	0.0046
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0045
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0045
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0045
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0045
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0045
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0045
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0043
77	L-lactate dehydrogenase B chain	LDHB	0.0043
12	Alcohol dehydrogenase class 3	ADH5	0.0043
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0043
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0043
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0043
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0043
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0043
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0042
5934	Cytochrome P450 26A1	CYP26A1	0.0042
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0042
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0042
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0041
13	Aminomethyltransferase, mitochondrial	AMT	0.0041
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0041
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0041
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0041
469	Annexin A1	ANXA1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0041
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
165	FL cytokine receptor	FLT3	0.004
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0039
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
3856	Fibroblast growth factor receptor 3	FGFR3	0.0039
1541	Metalloproteinase	mmp20	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
936	Ephrin type-A receptor 2	EPHA2	0.0039
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
279	Tyrosinase	TYR	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0038
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0037
2539	Tubulin alpha-1 chain	TUBA4A	0.0037
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0037
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0037
1650	Heme carrier protein 1	SLC46A1	0.0037
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0037
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
76	Nitric-oxide synthase, brain	NOS1	0.0037
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0037
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0036
1992	Vitamin D-binding protein	GC	0.0036
2207	Rhodopsin	RHO	0.0036
4773	Deoxycytidine kinase	DCK	0.0036
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
810	Heme oxygenase 1	HMOX1	0.0035
3391	Heme oxygenase 1	pbsA1	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0035
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0035
654	Flavin reductase	BLVRB	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
489	Monocarboxylate transporter 2	SLC16A7	0.0035
1864	RET proto-oncogene	RET	0.0035
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0035
6033	High affinity interleukin-8 receptor A	CXCR1	0.0034
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0034
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0034
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0034
3830	Calreticulin	CALR	0.0034
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0034
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
6034	Hydroxyindole O-methyltransferase	ASMT	0.0032
6035	Nuclear receptor ROR-beta	RORB	0.0032
6036	Eosinophil peroxidase	EPX	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
162	Retinoic acid receptor gamma-1	RARG	0.003
484	Tyrosine-protein kinase ABL2	ABL2	0.003
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.003
6122	Carbonic anhydrase 3	CA3	0.003
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
2298	Cytochrome P450-cam	camC	0.0029
6500	Phospholipase A2	PLA2G1B	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
765	Indoleamine 2,3-dioxygenase	IDO1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6174	50S ribosomal protein L32	rpmF	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2408	Tyrosine-protein kinase SYK	SYK	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
358	Cystathionine beta-synthase	CBS	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0026
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
759	Free fatty acid receptor 1	FFAR1	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
1630	Integrin beta-2	ITGB2	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
5923	Microtubule-associated protein tau	MAPT	0.0023
5924	Microtubule-associated protein 4	MAP4	0.0023
2021	Thrombomodulin	THBD	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
1039	Histone deacetylase 9	HDAC9	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
2091	Endoplasmin	HSP90B1	0.0021
3007	Carbonic anhydrase 12	CA12	0.0021
4205	Carbonic anhydrase 9	CA9	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
6048	Troponin C, skeletal muscle	TNNC2	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
293	Gamma-glutamyl hydrolase	GGH	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
2268	Cholesterol oxidase	choB	0.002
2822	Cholesterol oxidase	choA	0.002
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
1243	Cathepsin D	CTSD	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
6459	Glycodelin	PAEP	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
6221	Steroid hormone receptor ERR1	ESRRA	0.0018
572	Integrin alpha-L	ITGAL	0.0018
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0018
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
6042	Prostaglandin reductase 2	PTGR2	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
4217	Telomerase reverse transcriptase	TERT	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
735	Alanine aminotransferase 1	GPT	0.0016
3904	Alanine aminotransferase 2	GPT2	0.0016
1792	Tissue-type plasminogen activator	PLAT	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6755	Poliovirus receptor	PVR	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3102	Flavohemoprotein	hmp	0.0015
4969	Flavohemoprotein	hmp	0.0015
4692	A/G-specific adenine glycosylase	mutY	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0014
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
2802	Endoglucanase G	celCCG	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
5798	Mitogen-activated protein kinase 11	MAPK11	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0013
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0013
2320	Thymidine kinase, cytosolic	TK1	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
4486	Phenol 2-hydroxylase component B	pheA2	0.0013
4439	Ferredoxin reductase	bphA4	0.0013
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0013
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0013
5117	Dihydrolipoyl dehydrogenase	lpd	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0012
5122	Mersacidin decarboxylase	mrsD	0.0012
526	Thioredoxin reductase	trxB	0.0012
3767	Thioredoxin reductase	trxB	0.0012
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0012
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0012
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0012
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0012
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0012
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0012
5115	FkbI	fkbI	0.0012
3133	UDP-galactopyranose mutase	glf	0.0012
5099	UDP-galactopyranose mutase	glf	0.0012
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0012
5095	Putidaredoxin reductase	camA	0.0012
5083	Cryptochrome DASH	cry	0.0012
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0012
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5081	L-aspartate oxidase	nadB	0.0012
5111	Phenylacetone monooxygenase	pamO	0.0012
1410	Oxidoreductase	HSD17B6	0.0012
4725	Oxidoreductase	Not Available	0.0012
5124	Oxidoreductase	Not Available	0.0012
5109	Outer membrane protein p64k or PM-6	m-6	0.0012
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
85	Growth hormone receptor	GHR	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
1295	Fatty acid synthase	FASN	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
6218	Pannexin-1	PANX1	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4440	NADH peroxidase	npr	0.0011
5072	N,N-dimethylglycine oxidase	dmg	0.0011
5073	Ferredoxin--NADP reductase	petH	0.0011
5076	Ferredoxin--NADP reductase	fpr	0.0011
5119	Ferredoxin--NADP reductase	petH	0.0011
5121	Ferredoxin--NADP reductase	fpr	0.0011
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0011
4948	Cytochrome c-553	Not Available	0.0011
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0011
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0011
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
4923	Cytochrome c3	DvMF_2499	0.0011
4945	Cytochrome c3	Not Available	0.0011
4949	Cytochrome c3	DVU_3171	0.0011
4968	Cytochrome c3	cytc3	0.0011
4997	Cytochrome c3	SO_2727	0.0011
5219	Cytochrome c3	cyd	0.0011
4902	Nine-heme cytochrome c	Ddes_2038	0.0011
3189	High-molecular-weight cytochrome c	hmcA	0.0011
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0011
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0011
2526	NADPH-ferredoxin reductase fprA	fprA	0.0011
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0011
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0011
2470	Pyruvate oxidase	pox5	0.0011
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0011
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
126	D-lactate dehydrogenase	dld	0.001
3545	D-lactate dehydrogenase	Not Available	0.001
4510	D-lactate dehydrogenase	ldhA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.001
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.001
2893	Glycine oxidase	thiO	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0009
2567	Thymidylate synthase thyX	thyX	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
2823	Trypanothione reductase	TPR	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2769	P-hydroxybenzoate hydroxylase	pobA	0.0009
2809	P-hydroxybenzoate hydroxylase	pobA	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
1184	Interferon beta	IFNB1	0.0008
2380	Monomeric sarcosine oxidase	soxA	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
6645	D-amino-acid oxidase	DAO	0.0008
1867	Major prion protein	PRNP	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4916	Cyanoglobin	glbN	0.0006
4943	Cytochrome c6	petJ	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4909	CooA protein	cooA	0.0006
5000	HemO	hemO	0.0006
4961	Hemophore HasA	hasA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4910	Cytoglobin	CYGB	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4972	P450cin	cinA	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
6677	Myelin P2 protein	PMP2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
4920	Peroxidase/catalase	katG	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
2119	Cytochrome b5	CYB5A	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
4990	PpcA	ppcA	0.0005
4037	Hypothetical protein	GPX1	0.0005
4297	Hypothetical protein	SP_1951	0.0005
4521	Hypothetical protein	BC_2969	0.0005
4540	Hypothetical protein	TM_1070	0.0005
4555	Hypothetical protein	MT1739	0.0005
4569	Hypothetical protein	mshD	0.0005
4578	Hypothetical protein	PA3270	0.0005
4747	Hypothetical protein	PA3967	0.0005
5177	Hypothetical protein	TM_0096	0.0005
5194	Hypothetical protein	PA1204	0.0005
5240	Hypothetical protein	Rv2991	0.0005
5370	Hypothetical protein	TM_1158	0.0005
5710	Hypothetical protein	Tb927.5.1360	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
1439	Lactotransferrin	LTF	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
2440	Endoglucanase F	celCCF	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01136 - Carvedilol

Targets

Enzymes

Transporters

Predictions