DT-Web

DB01287 - Dihydroergotoxine


Identification
Name Dihydroergotoxine
Accession Number DB01287
Type small molecule
Description Dihydroergotoxine is a cerebral vasodilator. Dihydroergotoxine is a mixture of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. It has been proposed to be a neuroprotective agent. The mechanism of its therapeutic actions is not clear.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 679.783
Groups approved
Monoisotopic Weight 679.267584003
Pharmacology
Indication For potential use in the treatment of Alzheimer's disease.
Mechanism of action Dihydroergotoxine is a mixture of three different ergotaman-3',6',18-triones, dihydroergocornine, dihydroergocristine, and dihydroergocryptine. It has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. Specifically it binds to the Dopamine D2 receptor and the GABAA receptor.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Ischemia with risk of gangrene
Almotriptan Possible severe and prolonged vasoconstriction
Atenolol Ischemia with risk of gangrene
Bisoprolol Ischemia with risk of gangrene
Carvedilol Ischemia with risk of gangrene
Delavirdine The antiretroviral agent may increase the ergot derivative toxicity
Efavirenz The antiretroviral agent may increase the ergot derivative toxicity
Eletriptan Possible severe and prolonged vasoconstriction
Erythromycin Possible ergotism and severe ischemia with this combination
Esmolol Ischemia with risk of gangrene
Frovatriptan Possible severe and prolonged vasoconstriction
Isosorbide Dinitrate Possible antagonism of action
Isosorbide Mononitrate Possible antagonism of action
Labetalol Ischemia with risk of gangrene
Metoprolol Ischemia with risk of gangrene
Nadolol Ischemia with risk of gangrene
Naratriptan Possible severe and prolonged vasocontriction
Nitroglycerin Possible antagonism of action
Oxprenolol Ischemia with risk of gangrene
Pentaerythritol Tetranitrate Possible antagonism of action
Pindolol Ischemia with risk of gangrene
Propranolol Ischemia with risk of gangrene
Timolol Ischemia with risk of gangrene
Food Interactions Not Available

Targets


D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist,agonist
References
  • Flynn BL, Ranno AE: Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97. - Pubmed
  • Markstein R: Hydergine: interaction with the neurotransmitter systems in the central nervous system. J Pharmacol. 1985;16 Suppl 3:1-17. - Pubmed
  • Wadworth AN, Chrisp P: Co-dergocrine mesylate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in age-related cognitive decline. Drugs Aging. 1992 May-Jun;2(3):153-73. - Pubmed
  • Korneyev AY, Cincotta AH: Identification of hepatic, non-monoamine, dihydroergocryptine binding sites with significant gender differences. Life Sci. 1996;58(12):241-8. - Pubmed
DTHybrid score 0.3113
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions antagonist,agonist
References
  • Flynn BL, Ranno AE: Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97. - Pubmed
  • Markstein R: Hydergine: interaction with the neurotransmitter systems in the central nervous system. J Pharmacol. 1985;16 Suppl 3:1-17. - Pubmed
  • Wadworth AN, Chrisp P: Co-dergocrine mesylate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in age-related cognitive decline. Drugs Aging. 1992 May-Jun;2(3):153-73. - Pubmed
  • Korneyev AY, Cincotta AH: Identification of hepatic, non-monoamine, dihydroergocryptine binding sites with significant gender differences. Life Sci. 1996;58(12):241-8. - Pubmed
DTHybrid score 0.3047
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions antagonist
References
  • Markstein R: Hydergine: interaction with the neurotransmitter systems in the central nervous system. J Pharmacol. 1985;16 Suppl 3:1-17. - Pubmed
  • Korneyev AY, Cincotta AH: Identification of hepatic, non-monoamine, dihydroergocryptine binding sites with significant gender differences. Life Sci. 1996;58(12):241-8. - Pubmed
DTHybrid score 0.4505
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions antagonist
References
  • Markstein R: Hydergine: interaction with the neurotransmitter systems in the central nervous system. J Pharmacol. 1985;16 Suppl 3:1-17. - Pubmed
  • Korneyev AY, Cincotta AH: Identification of hepatic, non-monoamine, dihydroergocryptine binding sites with significant gender differences. Life Sci. 1996;58(12):241-8. - Pubmed
DTHybrid score 0.4138
Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action unknown
Actions agonist
References
  • Tvrdeic A, Pericic D: Effect of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors. Coll Antropol. 2003;27 Suppl 1:175-82. - Pubmed
  • Tvrdeic A, Pericic D: Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore. Eur J Pharmacol. 1991 Sep 4;202(1):109-11. - Pubmed
  • Korneyev AY, Cincotta AH: Identification of hepatic, non-monoamine, dihydroergocryptine binding sites with significant gender differences. Life Sci. 1996;58(12):241-8. - Pubmed
DTHybrid score 0.2395

Enzymes


Glutamine synthetase
Name Glutamine synthetase
Gene Name GLUL
Actions inducer
References
  • Pericic D: Effects of acute and subacute treatment with ergot drugs on the GABA system in specific brain regions. J Pharm Pharmacol. 1981 Oct;33(10):655-9. - Pubmed
DTHybrid score 0.3451

Predictions


Id Partner name Gene Name Score
3426 Glutamine synthetase glnA 0.3451
831 D(2) dopamine receptor DRD2 0.2382
632 Alpha-1B adrenergic receptor ADRA1B 0.1617
4119 Cytochrome P450 2D6 CYP2D6 0.1543
4512 Cytochrome P450 3A4 CYP3A4 0.1416
629 Alpha-2B adrenergic receptor ADRA2B 0.132
320 5-hydroxytryptamine 1A receptor HTR1A 0.1281
378 Alpha-2C adrenergic receptor ADRA2C 0.1267
590 5-hydroxytryptamine 2C receptor HTR2C 0.1262
4200 Cytochrome P450 1A2 CYP1A2 0.0997
432 D(4) dopamine receptor DRD4 0.0961
163 D(1B) dopamine receptor DRD5 0.0931
638 D(3) dopamine receptor DRD3 0.0907
492 Histamine H1 receptor HRH1 0.0858
789 Alpha-1D adrenergic receptor ADRA1D 0.0846
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0771
1588 Multidrug resistance protein 1 ABCB1 0.0712
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0694
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0689
436 5-hydroxytryptamine 2B receptor HTR2B 0.0686
725 5-hydroxytryptamine 1D receptor HTR1D 0.0673
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0666
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0644
824 Sodium-dependent serotonin transporter SLC6A4 0.0606
885 5-hydroxytryptamine 1B receptor HTR1B 0.0599
716 5-hydroxytryptamine 7 receptor HTR7 0.0588
6016 Cytochrome P450 2C19 CYP2C19 0.0582
4757 Cytochrome P450 2C9 CYP2C9 0.0513
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0481
587 Serum albumin ALB 0.048
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0477
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0442
6013 Cytochrome P450 2E1 CYP2E1 0.0441
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0439
131 Synaptic vesicular amine transporter SLC18A2 0.0432
617 Muscarinic acetylcholine receptor M2 CHRM2 0.043
6145 Solute carrier family 22 member 1 SLC22A1 0.0428
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0427
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0406
766 Beta-2 adrenergic receptor ADRB2 0.0405
1256 5-hydroxytryptamine 6 receptor HTR6 0.0402
193 Beta-1 adrenergic receptor ADRB1 0.0402
713 Sodium-dependent dopamine transporter SLC6A3 0.0389
921 Glutamate receptor 2 GRIA2 0.037
3941 Amine oxidase [flavin-containing] A MAOA 0.0355
4118 Cytochrome P450 3A5 CYP3A5 0.0347
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0344
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0331
6030 Cytochrome P450 2B6 CYP2B6 0.0331
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0323
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0323
85 Growth hormone receptor GHR 0.0319
820 Glycine receptor subunit alpha-2 GLRA2 0.031
6107 Cytochrome P450 3A7 CYP3A7 0.0297
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0292
461 Glycine receptor subunit alpha-3 GLRA3 0.0291
3923 Cholinesterase BCHE 0.0287
6024 Cytochrome P450 1A1 CYP1A1 0.0279
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0275
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0272
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.026
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0259
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0258
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0253
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0246
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0237
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0237
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0236
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0236
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0236
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0212
4924 Cytochrome P450 2C8 CYP2C8 0.0212
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0209
6106 Cytochrome P450 2C18 CYP2C18 0.0208
341 5-hydroxytryptamine 3 receptor HTR3A 0.0201
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0199
811 Translocator protein TSPO 0.019
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0187
466 Solute carrier family 12 member 3 SLC12A3 0.0184
528 5-hydroxytryptamine 1E receptor HTR1E 0.0182
465 Calmodulin CALM1 0.018
468 Cytochrome P450 4A11 CYP4A11 0.0176
482 Glycine receptor subunit alpha-1 GLRA1 0.0172
6151 Monocarboxylate transporter 10 SLC16A10 0.0169
6144 Solute carrier family 22 member 2 SLC22A2 0.0166
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0165
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
295 Carbonic anhydrase 1 CA1 0.0149
6147 Solute carrier family 22 member 3 SLC22A3 0.0147
705 Glutamate receptor 1 GRIA1 0.0146
174 Sigma 1-type opioid receptor SIGMAR1 0.0146
94 5-hydroxytryptamine 4 receptor HTR4 0.0145
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0144
159 Penicillin-binding protein 2B penA 0.0143
6121 Penicillin-binding protein 2B penA 0.0143
124 Histamine H2 receptor HRH2 0.0139
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0138
357 Carbonic anhydrase 2 CA2 0.0138
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0138
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0137
317 Methionine-R-sulfoxide reductase SEPX1 0.0135
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0135
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0134
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0134
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0134
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0134
537 ATP synthase delta chain, mitochondrial ATP5D 0.0132
3939 Amine oxidase [flavin-containing] B MAOB 0.0124
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0124
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0119
191 Peptide methionine sulfoxide reductase MSRA 0.0114
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0112
474 Acetylcholinesterase ACHE 0.0109
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0108
6142 Solute carrier family 22 member 8 SLC22A8 0.0105
828 Phenylalanine-4-hydroxylase PAH 0.0104
3109 Phenylalanine-4-hydroxylase phhA 0.0104
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0103
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0103
840 Methionine synthase reductase, mitochondrial MTRR 0.01
3810 Catechol O-methyltransferase COMT 0.0099
5718 Cytochrome P450 2A6 CYP2A6 0.0099
6020 Aldehyde oxidase AOX1 0.0098
923 Glutamate receptor 3 GRIA3 0.0098
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0098
5 Glutaminase liver isoform, mitochondrial GLS2 0.0098
917 Glutaminase kidney isoform, mitochondrial GLS 0.0098
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0098
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0098
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0098
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0098
5261 Phosphoribosylformylglycinamidine synthase purL 0.0098
118 Organic cation/carnitine transporter 2 SLC22A5 0.0097
1729 Solute carrier family 22 member 6 SLC22A6 0.0096
1517 Beta-3 adrenergic receptor ADRB3 0.0095
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0092
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0089
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0083
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0083
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0083
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0083
1008 CTP synthase 1 CTPS 0.0083
3989 Glutaminyl-tRNA synthetase QARS 0.0083
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0083
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0083
20 Prostaglandin G/H synthase 1 PTGS1 0.0082
3917 Methylenetetrahydrofolate reductase MTHFR 0.0079
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0078
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0078
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0078
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0076
6070 Nischarin NISCH 0.0075
2795 Methionine aminopeptidase 2 METAP2 0.0075
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0072
263 Neutral amino acid transporter B(0) SLC1A5 0.007
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.007
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.007
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
413 Amidophosphoribosyltransferase PPAT 0.0068
2515 Amidophosphoribosyltransferase purF 0.0068
3714 Amidophosphoribosyltransferase purF 0.0068
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0068
4120 NADPH--cytochrome P450 reductase POR 0.0067
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0066
6 Coagulation factor XIII A chain F13A1 0.0066
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0065
314 System N amino acid transporter 1 SLC38A3 0.0064
172 Potassium channel subfamily K member 1 KCNK1 0.0061
6432 Transporter snf 0.006
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0059
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0058
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0058
1656 CYP2B protein CYP2B 0.0056
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0056
696 Kappa-type opioid receptor OPRK1 0.0055
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0048
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0048
6138 Multidrug resistance protein 3 ABCB4 0.0043
776 Bile salt export pump ABCB11 0.0043
833 Organic cation/carnitine transporter 1 SLC22A4 0.0042
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0042
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0039
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0038
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0037
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0037
164 Histamine H4 receptor HRH4 0.0037
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0036
6859 Protein S100-A4 S100A4 0.0035
2981 Phospholipase A2, membrane associated PLA2G2A 0.0033
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0032
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0031
233 Potassium channel subfamily K member 2 KCNK2 0.0031
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0031
3811 Cytochrome P450 19A1 CYP19A1 0.003
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.003
592 Carbonic anhydrase 4 CA4 0.003
4026 Aspartyl aminopeptidase DNPEP 0.003
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.003
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.003
1047 Excitatory amino acid transporter 2 SLC1A2 0.003
926 Metabotropic glutamate receptor 7 GRM7 0.003
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.003
4016 Excitatory amino acid transporter 5 SLC1A7 0.003
4019 Excitatory amino acid transporter 4 SLC1A6 0.003
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.003
1912 Excitatory amino acid transporter 1 SLC1A3 0.003
927 Metabotropic glutamate receptor 8 GRM8 0.003
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.003
4017 5-oxoprolinase OPLAH 0.003
922 Glutamate receptor 4 GRIA4 0.003
925 Metabotropic glutamate receptor 4 GRM4 0.003
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.003
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.003
4020 Glutamyl aminopeptidase ENPEP 0.003
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.003
4018 Glutamate receptor delta-2 subunit GRID2 0.003
4027 Glutamate receptor delta-1 subunit GRID1 0.003
664 Glutamate decarboxylase 2 GAD2 0.003
3890 Glutamate decarboxylase 2 GAD2 0.003
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0029
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0029
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0029
1618 High affinity nerve growth factor receptor NTRK1 0.0028
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0028
3947 Xanthine dehydrogenase/oxidase XDH 0.0028
1898 Cytochrome P450 1B1 CYP1B1 0.0027
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0027
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0026
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0026
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0026
1360 Sphingomyelin phosphodiesterase SMPD1 0.0026
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0026
625 Glutamate carboxypeptidase 2 FOLH1 0.0025
665 Phosphoserine aminotransferase PSAT1 0.0025
4652 Phosphoserine aminotransferase serC 0.0025
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0025
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0025
420 Glutamate decarboxylase 1 GAD1 0.0025
3900 Glutamate decarboxylase 1 GAD1 0.0025
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0024
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0024
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0024
916 Metabotropic glutamate receptor 1 GRM1 0.0024
1671 Excitatory amino acid transporter 3 SLC1A1 0.0023
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0023
3877 Growth-inhibiting protein 18 GIG18 0.0023
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0023
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0023
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
763 Tyrosine aminotransferase TAT 0.0022
5493 Tyrosine aminotransferase Not Available 0.0022
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0022
426 Aspartate aminotransferase, mitochondrial GOT2 0.0022
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0022
735 Alanine aminotransferase 1 GPT 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0022
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0021
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0021
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0021
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.002
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.002
153 Dopamine beta-hydroxylase DBH 0.002
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0019
33 Cystine/glutamate transporter SLC7A11 0.0019
1374 Natriuretic peptides B NPPB 0.0019
1827 Gap junction alpha-1 protein GJA1 0.0019
1908 Vascular cell adhesion protein 1 VCAM1 0.0019
251 Alcohol dehydrogenase 1A ADH1A 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0019
467 Delta-type opioid receptor OPRD1 0.0018
444 Alcohol dehydrogenase 1B ADH1B 0.0016
904 Glutathione S-transferase P GSTP1 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0015
738 Monocarboxylate transporter 1 SLC16A1 0.0015
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0015
1268 Neuropeptide S receptor NPSR1 0.0015
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
6073 Potassium channel subfamily K member 9 KCNK9 0.0014
6072 Potassium channel subfamily K member 3 KCNK3 0.0014
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0012
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0011
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0011
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0011
2207 Rhodopsin RHO 0.001
6031 Cytochrome P450 3A43 CYP3A43 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0007
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0006
862 Multidrug resistance-associated protein 1 ABCC1 0.0006
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0005
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