DT-Web

DB00918 - Almotriptan


Identification
Name Almotriptan
Accession Number DB00918 (APRD00169)
Type small molecule
Description Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Almotriptan does not prevent migraine attacks.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 335.464
Groups approved
Monoisotopic Weight 335.166747749
Pharmacology
Indication For the treatment of acute migraine headache in adults
Mechanism of action Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction.
Absorption Not Available
Protein binding 35%
Biotransformation Not Available
Route of elimination Almotriptan is eliminated primarily by renal excretion (about 75% of the oral dose), with approximately 40% of an administered dose excreted unchanged in urine. Approximately 13% of the administered dose is excreted via feces, both unchanged and metabolized.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Citalopram Increased risk of CNS adverse effects
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Almotriptan. Use an initial almotriptan dose of 6.25mg when using almotriptan with a strong CYP3A4 inhibitor, and do not exceed 12.5mg of almotriptan in any 24-hour period. Avoid concurrent use of almotriptan with a strong CYP3A4 inhibitor in patients with impaired hepatic or renal function.
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroergotamine Possible severe and prolonged vasoconstriction
Dihydroergotoxine Possible severe and prolonged vasoconstriction
Ergonovine Possible severe and prolonged vasoconstriction
Ergotamine Possible severe and prolonged vasoconstriction
Escitalopram Increased risk of CNS adverse effects
Fluoxetine Increased risk of CNS adverse effects
Fluvoxamine Increased risk of CNS adverse effects
Isocarboxazid The MAO inhibitor, isocarboxazid, may decrease the metabolism and clearance of the serotonin 5-HT receptor agonist, almotriptan. Concomitant therapy is contraindicated.
Itraconazole This potent CYP3A4 inhibitor increases the effect and toxicity of the triptan
Ketoconazole This potent CYP3A4 inhibitor increases the effect and toxicity of the triptan
Methylergonovine Possible severe and prolonged vasoconstriction
Methysergide Possible severe and prolonged vasoconstriction
Nefazodone Increased risk of CNS adverse effects
Paroxetine Increased risk of CNS adverse effects
Phenelzine The MAO inhibitor, phenelzine, may decrease the metabolism and clearance of the serotonin 5-HT receptor agonist, almotriptan. Concomitant therapy is contraindicated.
Sertraline Increased risk of CNS adverse effects
Sibutramine Increased risk of CNS adverse effects
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine The MAO inhibitor, Tranylcypromine, may reduce the metabolism and clearance of the serotonin 5-HT1D receptor agonist, Almotriptan. Risk of serotonin syndrome and Almotriptan toxicity. Concomitant therapy should be avoided.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of almotriptan by decreasing its metabolism. The initial and maximum doses should not exceed 6.25 mg and 12.5 mg, respectively during concomitant therapy. Concomitant therapy should be avoided in patients with impaired hepatic or renal function.
Zolmitriptan Concomitant use of two serotonin 5-HT1D receptor agonists, such as zolmitriptan and almotriptan, may result in additive vasoconstrictive effects. Concomitant use within 24 hours is contraindicated.
Food Interactions
  • Take without regard to meals.
  • The absorption is unaffected by food.

Targets


5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions agonist
References
  • Napier C, Stewart M, Melrose H, Hopkins B, McHarg A, Wallis R: Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3):259-68. - Pubmed
  • Fleishaker JC, Sisson TA, Carel BJ, Azie NE: Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers. Clin Pharmacol Ther. 2000 May;67(5):498-503. - Pubmed
  • van den Broek RW, MaassenVanDenBrink A, de Vries R, Bogers AJ, Stegmann AP, Avezaat CJ, Saxena PR: Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels. Eur J Pharmacol. 2000 Oct 27;407(1-2):165-73. - Pubmed
  • Knyihar-Csillik E, Tajti J, Csillik AE, Chadaide Z, Mihaly A, Vecsei L: Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model. Eur J Neurosci. 2000 Nov;12(11):3991-4002. - Pubmed
  • Bou J, Domenech T, Puig J, Heredia A, Gras J, Fernandez-Forner D, Beleta J, Palacios JM: Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol. 2000 Dec 20;410(1):33-41. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3159
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions agonist
References
  • Napier C, Stewart M, Melrose H, Hopkins B, McHarg A, Wallis R: Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3):259-68. - Pubmed
  • Bou J, Domenech T, Puig J, Heredia A, Gras J, Fernandez-Forner D, Beleta J, Palacios JM: Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol. 2000 Dec 20;410(1):33-41. - Pubmed
  • Gras J, Llupia J, Llenas J, Palacios JM: Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung. 2001 Sep;51(9):726-32. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.294

Enzymes


Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Actions substrate
References
  • McEnroe JD, Fleishaker JC: Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46. - Pubmed
  • Gras J, Llenas J, Jansat JM, Jauregui J, Cabarrocas X, Palacios JM: Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34. - Pubmed
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
DTHybrid score 0.49
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
  • McEnroe JD, Fleishaker JC: Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46. - Pubmed
DTHybrid score 0.6773
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • McEnroe JD, Fleishaker JC: Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46. - Pubmed
DTHybrid score 0.5389
Dimethylaniline monooxygenase [N-oxide-forming] 3
Name Dimethylaniline monooxygenase [N-oxide-forming] 3
Gene Name FMO3
Actions substrate
References
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
DTHybrid score 0.1306
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
DTHybrid score 0.5292
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
DTHybrid score 0.441
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
DTHybrid score 0.3328
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Salva M, Jansat JM, Martinez-Tobed A, Palacios JM: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. - Pubmed
DTHybrid score 0.3352

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.3868
1588 Multidrug resistance protein 1 ABCB1 0.2646
4118 Cytochrome P450 3A5 CYP3A5 0.2202
3939 Amine oxidase [flavin-containing] B MAOB 0.192
6030 Cytochrome P450 2B6 CYP2B6 0.1794
320 5-hydroxytryptamine 1A receptor HTR1A 0.1763
6107 Cytochrome P450 3A7 CYP3A7 0.1664
6024 Cytochrome P450 1A1 CYP1A1 0.143
511 5-hydroxytryptamine 1F receptor HTR1F 0.1391
318 Alpha-2A adrenergic receptor ADRA2A 0.1318
5718 Cytochrome P450 2A6 CYP2A6 0.1274
502 5-hydroxytryptamine 2A receptor HTR2A 0.1208
831 D(2) dopamine receptor DRD2 0.1166
590 5-hydroxytryptamine 2C receptor HTR2C 0.1025
23 D(1A) dopamine receptor DRD1 0.1003
629 Alpha-2B adrenergic receptor ADRA2B 0.0984
556 Alpha-1A adrenergic receptor ADRA1A 0.0972
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0965
20 Prostaglandin G/H synthase 1 PTGS1 0.0964
824 Sodium-dependent serotonin transporter SLC6A4 0.0954
638 D(3) dopamine receptor DRD3 0.0945
492 Histamine H1 receptor HRH1 0.0919
587 Serum albumin ALB 0.0917
378 Alpha-2C adrenergic receptor ADRA2C 0.0907
436 5-hydroxytryptamine 2B receptor HTR2B 0.0829
432 D(4) dopamine receptor DRD4 0.0829
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0794
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0726
632 Alpha-1B adrenergic receptor ADRA1B 0.0718
163 D(1B) dopamine receptor DRD5 0.0688
713 Sodium-dependent dopamine transporter SLC6A3 0.0652
6106 Cytochrome P450 2C18 CYP2C18 0.0632
193 Beta-1 adrenergic receptor ADRB1 0.0628
766 Beta-2 adrenergic receptor ADRB2 0.0613
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.061
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0598
3811 Cytochrome P450 19A1 CYP19A1 0.0598
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0581
1898 Cytochrome P450 1B1 CYP1B1 0.0545
716 5-hydroxytryptamine 7 receptor HTR7 0.0531
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.052
341 5-hydroxytryptamine 3 receptor HTR3A 0.0517
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0496
6145 Solute carrier family 22 member 1 SLC22A1 0.0495
1729 Solute carrier family 22 member 6 SLC22A6 0.0484
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0469
6144 Solute carrier family 22 member 2 SLC22A2 0.0466
862 Multidrug resistance-associated protein 1 ABCC1 0.0465
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0458
290 Prostaglandin G/H synthase 2 PTGS2 0.0458
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0456
789 Alpha-1D adrenergic receptor ADRA1D 0.0455
274 Muscarinic acetylcholine receptor M5 CHRM5 0.044
260 Cytochrome P450 51 ERG11 0.0433
761 Cytochrome P450 51 ERG11 0.0433
3163 Cytochrome P450 51 cyp51 0.0433
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0428
528 5-hydroxytryptamine 1E receptor HTR1E 0.0412
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0371
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0368
118 Organic cation/carnitine transporter 2 SLC22A5 0.0365
1256 5-hydroxytryptamine 6 receptor HTR6 0.035
776 Bile salt export pump ABCB11 0.0336
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0327
847 Mu-type opioid receptor OPRM1 0.0311
136 Estrogen receptor ESR1 0.0303
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.029
6147 Solute carrier family 22 member 3 SLC22A3 0.0288
871 Glucocorticoid receptor NR3C1 0.0269
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0263
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0262
731 HIV-1 protease HIV-1 protease 0.0261
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0259
36 Insulin receptor INSR 0.0258
833 Organic cation/carnitine transporter 1 SLC22A4 0.0257
6031 Cytochrome P450 3A43 CYP3A43 0.0255
6142 Solute carrier family 22 member 8 SLC22A8 0.0254
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0253
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0244
844 Epidermal growth factor receptor EGFR 0.0243
6143 Solute carrier family 22 member 7 SLC22A7 0.024
131 Synaptic vesicular amine transporter SLC18A2 0.0239
467 Delta-type opioid receptor OPRD1 0.0238
1757 Myeloperoxidase MPO 0.0236
465 Calmodulin CALM1 0.0234
146 Androgen receptor AR 0.0234
1517 Beta-3 adrenergic receptor ADRB3 0.0234
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0232
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0232
6102 Arylamine N-acetyltransferase 2 NAT2 0.0231
696 Kappa-type opioid receptor OPRK1 0.0226
2164 Multidrug resistance-associated protein 4 ABCC4 0.0224
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0223
817 DNA topoisomerase 2-alpha TOP2A 0.0223
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0218
468 Cytochrome P450 4A11 CYP4A11 0.0217
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.021
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0203
3810 Catechol O-methyltransferase COMT 0.0203
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0199
183 Vascular endothelial growth factor A VEGFA 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0196
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0195
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0191
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0187
5787 Angiopoietin-1 receptor TEK 0.0183
124 Histamine H2 receptor HRH2 0.0182
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0182
504 Mast/stem cell growth factor receptor KIT 0.018
94 5-hydroxytryptamine 4 receptor HTR4 0.0176
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0176
3601 Dihydropteroate synthase 1 folP1 0.0175
3807 Dihydropteroate synthase 1 folP1 0.0175
3808 Dihydropteroate synthase 2 folP2 0.0175
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0174
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0173
16 Adenosine A1 receptor ADORA1 0.0171
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.017
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0168
3923 Cholinesterase BCHE 0.0167
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0159
777 Tumor necrosis factor TNF 0.0157
6182 Cytochrome P450 2J2 CYP2J2 0.0157
228 Beta platelet-derived growth factor receptor PDGFRB 0.0156
1024 Solute carrier family 22 member 11 SLC22A11 0.0155
6014 Cytochrome P450 2A13 CYP2A13 0.0153
4604 Liver carboxylesterase 1 CES1 0.0149
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0149
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0146
1178 Adenosine A2a receptor ADORA2A 0.0144
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
122 P2Y purinoceptor 12 P2RY12 0.0138
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0136
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0135
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0135
6220 Aryl hydrocarbon receptor AHR 0.0134
869 Estrogen receptor beta ESR2 0.0133
474 Acetylcholinesterase ACHE 0.0132
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.013
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0129
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0127
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0127
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0123
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0123
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0123
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0122
811 Translocator protein TSPO 0.0122
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0122
1063 Signal transducer and activator of transcription 5B STAT5B 0.0122
380 Cytochrome P450 17A1 CYP17A1 0.0121
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0121
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0119
1192 Sulfotransferase 1A1 SULT1A1 0.0118
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0118
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0118
6141 Sodium/bile acid cotransporter SLC10A1 0.0117
1010 Cytochrome P450 51A1 CYP51A1 0.0116
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0116
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0116
1656 CYP2B protein CYP2B 0.0115
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
6148 Multidrug resistance-associated protein 7 ABCC10 0.0112
164 Histamine H4 receptor HRH4 0.0112
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0111
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0111
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0111
936 Ephrin type-A receptor 2 EPHA2 0.011
614 Progesterone receptor PGR 0.011
891 Dihydropteroate synthase folP 0.0109
5359 Dihydropteroate synthase folP 0.0109
7175 Dihydropteroate synthase sulI 0.0109
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0108
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0108
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0108
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0108
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0108
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0108
3947 Xanthine dehydrogenase/oxidase XDH 0.0108
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0108
4122 Histone deacetylase 2 HDAC2 0.0107
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0107
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0106
613 Atrial natriuretic peptide receptor A NPR1 0.0106
5698 Riboflavin synthase alpha chain ribE 0.0105
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0104
70 Type-1 angiotensin II receptor AGTR1 0.0104
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0103
161 Tubulin beta chain TUBB 0.0103
312 Tubulin beta chain TUB2 0.0103
373 Transthyretin TTR 0.0103
482 Glycine receptor subunit alpha-1 GLRA1 0.0102
818 50S ribosomal protein L10 rplJ 0.0102
408 Riboflavin kinase RFK 0.0101
3917 Methylenetetrahydrofolate reductase MTHFR 0.0101
365 Dihydrofolate reductase DHFR 0.0099
2381 Dihydrofolate reductase DFR1 0.0099
2833 Dihydrofolate reductase Not Available 0.0099
2931 Dihydrofolate reductase folA 0.0099
3544 Dihydrofolate reductase folA 0.0099
3682 Dihydrofolate reductase folA 0.0099
6642 Dihydrofolate reductase folA 0.0099
6756 Dihydrofolate reductase dfrA 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0097
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0096
6136 Multidrug resistance-associated protein 5 ABCC5 0.0096
571 Melatonin receptor type 1A MTNR1A 0.0096
362 Melatonin receptor type 1B MTNR1B 0.0096
484 Tyrosine-protein kinase ABL2 ABL2 0.0096
1483 Membrane copper amine oxidase AOC3 0.0095
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0095
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0094
232 Corticosteroid-binding globulin SERPINA6 0.0093
705 Glutamate receptor 1 GRIA1 0.0092
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0092
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0092
592 Carbonic anhydrase 4 CA4 0.0092
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0092
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0091
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0091
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0091
26 Vascular endothelial growth factor receptor 3 FLT4 0.0091
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0091
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.009
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.009
756 Sex hormone-binding globulin SHBG 0.009
407 Vascular endothelial growth factor receptor 2 KDR 0.0089
6020 Aldehyde oxidase AOX1 0.0089
952 Dipeptidyl peptidase 4 DPP4 0.0089
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0088
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0087
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0087
32 Vascular endothelial growth factor receptor 1 FLT1 0.0087
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0086
6137 Multidrug resistance-associated protein 6 ABCC6 0.0085
921 Glutamate receptor 2 GRIA2 0.0084
29 Tubulin beta-1 chain TUBB1 0.0084
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0084
295 Carbonic anhydrase 1 CA1 0.0083
537 ATP synthase delta chain, mitochondrial ATP5D 0.0083
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0083
4120 NADPH--cytochrome P450 reductase POR 0.0082
3913 Glutamic acid decarboxylase GAD65 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
518 Peroxidase/catalase T katG 0.0078
153 Dopamine beta-hydroxylase DBH 0.0078
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0076
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0075
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0075
654 Flavin reductase BLVRB 0.0075
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0075
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0075
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
6126 Carbonic anhydrase 7 CA7 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.007
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.007
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0069
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0069
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0069
357 Carbonic anhydrase 2 CA2 0.0069
4116 Dihydropteroate synthetase Not Available 0.0069
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0068
2112 Toll-like receptor 9 TLR9 0.0068
814 Ryanodine receptor 1 RYR1 0.0067
1050 Bile salt sulfotransferase SULT2A1 0.0067
735 Alanine aminotransferase 1 GPT 0.0067
3904 Alanine aminotransferase 2 GPT2 0.0067
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0067
4311 tRNA TRDMT1 0.0066
4325 tRNA trmD 0.0066
4328 tRNA trmD 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0065
427 Substance-P receptor TACR1 0.0064
284 DNA-directed RNA polymerase beta chain rpoB 0.0063
5773 DNA-directed RNA polymerase beta chain rpoB 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
823 Fibroblast growth factor receptor 2 FGFR2 0.0063
6432 Transporter snf 0.0063
737 Mineralocorticoid receptor NR3C2 0.0062
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
904 Glutathione S-transferase P GSTP1 0.0061
3932 Glutathione S-transferase A2 GSTA2 0.006
444 Alcohol dehydrogenase 1B ADH1B 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
251 Alcohol dehydrogenase 1A ADH1A 0.0059
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0059
634 Squalene monooxygenase SQLE 0.0058
7196 Squalene monooxygenase ERG1 0.0058
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
275 Arachidonate 5-lipoxygenase ALOX5 0.0058
5880 Thrombopoietin receptor MPL 0.0058
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0058
563 Thyroid peroxidase TPO 0.0058
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0057
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0057
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
1629 Transcription factor AP-1 JUN 0.0057
273 Apoptosis regulator Bcl-2 BCL2 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0056
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0056
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0055
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0055
856 Vitamin D3 receptor VDR 0.0055
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0054
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0053
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0052
49 Endothelin B receptor EDNRB 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
174 Sigma 1-type opioid receptor SIGMAR1 0.0051
6044 Serum paraoxonase/lactonase 3 PON3 0.0051
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0051
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
1618 High affinity nerve growth factor receptor NTRK1 0.0051
4203 Histamine N-methyltransferase HNMT 0.0049
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
976 Platelet glycoprotein IX GP9 0.0049
1541 Metalloproteinase mmp20 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
3404 Exotoxin A eta 0.0049
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0049
68 Cannabinoid receptor 1 CNR1 0.0048
6138 Multidrug resistance protein 3 ABCB4 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0048
1648 Elastin ELN 0.0048
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0048
714 Glutathione reductase, mitochondrial GSR 0.0047
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0047
88 Retinoic acid receptor RXR-beta RXRB 0.0047
3937 Fatty-acid amide hydrolase FAAH 0.0047
738 Monocarboxylate transporter 1 SLC16A1 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0046
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
6043 Putative G-protein coupled receptor 44 GPR44 0.0045
517 Alcohol dehydrogenase 1C ADH1C 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
239 Coagulation factor X F10 0.0044
6085 Fatty acid-binding protein, intestinal FABP2 0.0044
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0044
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0044
319 Opioid receptor, sigma 1 OPRS1 0.0044
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0043
208 DNA-directed RNA polymerase beta' chain rpoC 0.0043
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0043
581 Cytochrome P450 2R1 CYP2R1 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0042
3957 Adenosine deaminase ADA 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
558 Solute carrier family 12 member 1 SLC12A1 0.0039
6131 Carbonic anhydrase 14 CA14 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0039
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0039
165 FL cytokine receptor FLT3 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
3809 Estrogen-related receptor gamma ESRRG 0.0038
469 Annexin A1 ANXA1 0.0038
85 Growth hormone receptor GHR 0.0038
6122 Carbonic anhydrase 3 CA3 0.0037
162 Retinoic acid receptor gamma-1 RARG 0.0037
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
908 Glutathione S-transferase theta-1 GSTT1 0.0036
4103 Proteasome subunit beta type 2 PSMB2 0.0036
4102 Proteasome subunit beta type 5 PSMB5 0.0036
4101 Proteasome subunit beta type 1 PSMB1 0.0036
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
6174 50S ribosomal protein L32 rpmF 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
268 Adenosine A2b receptor ADORA2B 0.0034
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
84 Nuclear receptor 0B1 NR0B1 0.0034
1196 Complement decay-accelerating factor CD55 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
7 Nitric oxide synthase, inducible NOS2 0.0033
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0033
24 Thymidylate synthase TMP1 0.0033
359 Thymidylate synthase TYMS 0.0033
2626 Thymidylate synthase thyA 0.0033
2729 Thymidylate synthase thyA 0.0033
5352 Thymidylate synthase THYA 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
4192 DNA topoisomerase 2-beta TOP2B 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
1992 Vitamin D-binding protein GC 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.003
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0029
2808 Chloramphenicol acetyltransferase 3 cat3 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
1275 Estrogen sulfotransferase SULT1E1 0.0029
1630 Integrin beta-2 ITGB2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2298 Cytochrome P450-cam camC 0.0028
33 Cystine/glutamate transporter SLC7A11 0.0028
820 Glycine receptor subunit alpha-2 GLRA2 0.0028
3007 Carbonic anhydrase 12 CA12 0.0028
4205 Carbonic anhydrase 9 CA9 0.0028
780 Retinoic acid receptor RXR-gamma RXRG 0.0028
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0027
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0027
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0027
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0027
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0027
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0027
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6134 Sodium channel subunit beta-3 SCN3B 0.0027
6133 Sodium channel subunit beta-2 SCN2B 0.0027
6132 Sodium channel subunit beta-1 SCN1B 0.0027
6135 Sodium channel subunit beta-4 SCN4B 0.0027
6127 Carbonic anhydrase-related protein CA8 0.0027
6129 Carbonic anhydrase-related protein 11 CA11 0.0027
6128 Carbonic anhydrase-related protein 10 CA10 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2417 Chloramphenicol acetyltransferase cat 0.0027
3278 Chloramphenicol acetyltransferase cat 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
751 Potassium channel subfamily K member 6 KCNK6 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
2810 Dr hemagglutinin structural subunit draA 0.0027
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
327 Glutathione reductase gor 0.0025
5110 Glutathione reductase GR2 0.0025
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0025
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0025
172 Potassium channel subfamily K member 1 KCNK1 0.0024
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0024
358 Cystathionine beta-synthase CBS 0.0024
6130 Carbonic anhydrase 13 CA13 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
5934 Cytochrome P450 26A1 CYP26A1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1852 Microtubule-associated protein 2 MAP2 0.0023
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0023
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0023
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
572 Integrin alpha-L ITGAL 0.0022
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
4217 Telomerase reverse transcriptase TERT 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
2981 Phospholipase A2, membrane associated PLA2G2A 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
896 Glutathione S-transferase Mu 1 GSTM1 0.002
1820 Beta-nerve growth factor NGF 0.002
106 Cannabinoid receptor 2 CNR2 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
1864 RET proto-oncogene RET 0.0019
1039 Histone deacetylase 9 HDAC9 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0019
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
2207 Rhodopsin RHO 0.0018
54 Prothrombin F2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
291 Nitric-oxide synthase, endothelial NOS3 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3830 Calreticulin CALR 0.0017
6048 Troponin C, skeletal muscle TNNC2 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
2268 Cholesterol oxidase choB 0.0017
2822 Cholesterol oxidase choA 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0017
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0017
5798 Mitogen-activated protein kinase 11 MAPK11 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
2320 Thymidine kinase, cytosolic TK1 0.0017
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
267 Plasminogen activator inhibitor 1 SERPINE1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
1243 Cathepsin D CTSD 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
3233 Bile acid receptor NR1H4 0.0015
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
6221 Steroid hormone receptor ERR1 ESRRA 0.0015
6218 Pannexin-1 PANX1 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
2021 Thrombomodulin THBD 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
5923 Microtubule-associated protein tau MAPT 0.0014
5924 Microtubule-associated protein 4 MAP4 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
798 Osteocalcin BGLAP 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
1341 Histamine H3 receptor HRH3 0.0014
6859 Protein S100-A4 S100A4 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
3221 Cytochrome c4 cc4 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
1792 Tissue-type plasminogen activator PLAT 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
3102 Flavohemoprotein hmp 0.001
4969 Flavohemoprotein hmp 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
997 Protein kinase C beta type PRKCB 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
4439 Ferredoxin reductase bphA4 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5095 Putidaredoxin reductase camA 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5081 L-aspartate oxidase nadB 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
1410 Oxidoreductase HSD17B6 0.0008
4725 Oxidoreductase Not Available 0.0008
5124 Oxidoreductase Not Available 0.0008
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
4440 NADH peroxidase npr 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
3594 Deoxyribodipyrimidine photo-lyase phr 0.0007
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0007
5080 Deoxyribodipyrimidine photo-lyase phr 0.0007
5072 N,N-dimethylglycine oxidase dmg 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
2470 Pyruvate oxidase pox5 0.0007
5073 Ferredoxin--NADP reductase petH 0.0007
5076 Ferredoxin--NADP reductase fpr 0.0007
5119 Ferredoxin--NADP reductase petH 0.0007
5121 Ferredoxin--NADP reductase fpr 0.0007
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0007
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0007
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0007
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0007
2526 NADPH-ferredoxin reductase fprA fprA 0.0007
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0007
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
125 DNA polymerase beta POLB 0.0007
2893 Glycine oxidase thiO 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0006
2769 P-hydroxybenzoate hydroxylase pobA 0.0006
2809 P-hydroxybenzoate hydroxylase pobA 0.0006
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0006
2567 Thymidylate synthase thyX thyX 0.0006
2823 Trypanothione reductase TPR 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6645 D-amino-acid oxidase DAO 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑