DT-Web: DB00285

Identification

Name

Venlafaxine

Accession Number

DB00285 (APRD00125)

Type

small molecule

Description

Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. [Wikipedia]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

277.4018

Groups

approved

Monoisotopic Weight

277.204179113

Pharmacology

Indication

For the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain.

Mechanism of action

The exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotrasmitter activity in the CNS. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors.

Absorption

Venlafaxine is well absorbed. Food does not effect the absorption of venlafaxine or its subsequent metabolism into ODV. Bioavailability is 45% following oral administration. Time to steady state = 3 days.

Protein binding

The degree of binding of venlafaxine to human plasma is 27% ? 2% at concentrations ranging from 2.5 to 2215 ng/mL. The degree of ODV binding to human plasma is 30% ? 12% at concentrations ranging from 100 to 500 ng/mL. Protein-binding-induced drug interactions with venlafaxine are not expected.

Biotransformation

Undergoes extensive first pass metabolism in the liver to its major, active metabolite, ODV, and two minor, less active metabolites, N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. Formation of ODV is catalyzed by cytochrome P450 (CYP) 2D6, whereas N-demethylation is catalyzed by CYP3A4, 2C19 and 2C9. ODV possesses antidepressant activity that is comparable to that of venlfaxine.

Route of elimination

Renal elimination of venlafaxine and its metabolites is the primary route of excretion. Approximately 87% of a venlafaxine dose is recovered in the urine within 48 hours as either unchanged venlafaxine (5%), unconjugated ODV (29%), conjugated ODV (26%), or other minor inactive metabolites (27%).

Toxicity

Most patients overdosing with venlafaxine develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Almotriptan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Amitriptyline	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Amoxapine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Amprenavir	Amprenavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Amprenavir is initiated, discontinued, or dose changed.
Atazanavir	Atazanavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Atazanavir is initiated, discontinued, or dose changed.
Bromocriptine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Buspirone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Cabergoline	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Chlorpromazine	Chlorpromazine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Chlorpromazine is initiated, discontinued, or dose changed.
Cinacalcet	Cinacalcet, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Cinacalcet is initiated, discontinued, or dose changed.
Citalopram	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Clarithromycin	Clarithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Clarithromycin is initiated, discontinued, or dose changed.
Clomipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Cocaine	Cocaine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Cocaine is initiated, discontinued, or dose changed.
Conivaptan	Conivaptan, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Conivaptan is initiated, discontinued, or dose changed.
Darunavir	Darunavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Darunavir is initiated, discontinued, or dose changed.
Delavirdine	Delaviridine, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Delavirdine is initiated, discontinued, or dose changed.
Desipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dexfenfluramine	Risk of serotoninergic syndrome
Dextromethorphan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Diethylpropion	Risk of serotoninergic syndrome
Dihydroergotamine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dipivefrin	Venlafaxine may increase the tachycardic and vasopressor effects of dipivefrin. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Doxepin	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Duloxetine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Eletriptan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ephedrine	Venlafaxine may increase the tachycardic and vasopressor effects of ephedrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Epinephrine	Venlafaxine may increase the tachycardic and vasopressor effects of epinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Ergoloid mesylate	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergonovine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergotamine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Escitalopram	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Fenfluramine	Risk of serotoninergic syndrome
Fluoxetine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Fluvoxamine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Fosamprenavir	Fosamprenavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Fosamprenavir is initiated, discontinued, or dose changed.
Frovatriptan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Furazolidone	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Imatinib	Imatinib, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Imatinib is initiated, discontinued, or dose changed.
Imipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Indinavir	Indinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Indinavir is initiated, discontinued, or dose changed.
Isocarboxazid	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Isoniazid	Isoniazid, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Isoniazid is initiated, discontinued, or dose changed.
Itraconazole	Itraconaole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Itraconazole is initiated, discontinued, or dose changed.
Ketoconazole	Ketoconazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Ketoconazole is initiated, discontinued, or dose changed.
Linezolid	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Lithium	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Lopinavir	Lopinavir, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Lopinavir is initiated, discontinued, or dose changed.
Maprotiline	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Mazindol	Risk of serotoninergic syndrome
Meperidine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Methylergonovine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Metoclopramide	Possible serotoninergic syndrome with this combination
Miconazole	Miconazole, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Miconazole is initiated, discontinued, or dose changed.
Milnacipran	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Mirtazapine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Moclobemide	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Naratriptan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Nefazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Nelfinavir	Nelfinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Nelfinavir is initiated, discontinued, or dose changed.
Nicardipine	Nicardipine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Nicardipine is initiated, discontinued, or dose changed.
Norepinephrine	Venlafaxine may increase the tachycardic and vasopressor effects of Norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Nortriptyline	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Paroxetine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Pergolide	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Phenelzine	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Phentermine	Risk of serotoninergic syndrome
Phenylpropanolamine	Risk of serotoninergic syndrome
Posaconazole	Posaconazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Posaconazole is initiated, discontinued, or dose changed.
Procarbazine	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Promethazine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Propafenone	Propafenone increases the effect and toxicity of venlafaxine
Protriptyline	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Pseudoephedrine	Venlafaxine may increase the tachycardic and vasopressor effects of Pseudoephedrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Quinidine	Quinidine, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Quinidine is initiated, discontinued, or dose changed.
Quinupristin	This combination presents an increased risk of toxicity
Rasagiline	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Ritonavir	Ritonavir, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Ritonavir is initiated, discontinued, or dose changed.
Rizatriptan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
S-Adenosylmethionine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Saquinavir	Saquinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Saquinavir is initiated, discontinued, or dose changed.
Selegiline	Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Sertraline	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Sibutramine	Increased risk of serotonin syndrome. Concurrent therapy should be avoided.
St. John's Wort	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Sumatriptan	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Telithromycin	Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Telithromycin is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Terbinafine is initiated, discontinued, or dose changed.
Tramadol	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Triprolidine	The CNS depressants, Triprolidine and Venlafaxine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of venlafaxine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of venlafaxine if voriconazole is initiated, discontinued or dose changed.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and venlafaxine, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Take with food.
Avoid St.John's Wort.
Avoid alcohol.

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Chen F, Larsen MB, Sanchez C, Wiborg O: The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8. - Pubmed Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. - Pubmed Shang Y, Gibbs MA, Marek GJ, Stiger T, Burstein AH, Marek K, Seibyl JP, Rogers JF: Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. J Clin Psychopharmacol. 2007 Feb;27(1):71-5. - Pubmed Malizia AL, Melichar JM, Brown DJ, Gunn RN, Reynolds A, Jones T, Nutt DJ: Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo. J Psychopharmacol. 1997;11(3):279-81. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. - Pubmed Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. - Pubmed Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. - Pubmed Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. - Pubmed
DTHybrid score	0.4853
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. - Pubmed Beique JC, Lavoie N, de Montigny C, Debonnel G: Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15;349(1):129-32. - Pubmed Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. - Pubmed Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. - Pubmed Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. - Pubmed Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. - Pubmed
DTHybrid score	0.6361
Sodium-dependent dopamine transporter
Name	Sodium-dependent dopamine transporter
Gene Name	SLC6A3
Pharmacological action	unknown
Actions	inhibitor
References	Dawson LA, Nguyen HQ, Geiger A: Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism. Neuropharmacology. 1999 Aug;38(8):1153-63. - Pubmed Bourin M: [Psychopharmacological profile of venlafaxine] Encephale. 1999 Jun;25 Spec No 2:21-2; discussion 23-5. - Pubmed Barkin RL, Fawcett J: The management challenges of chronic pain: the role of antidepressants. Am J Ther. 2000 Jan;7(1):31-47. - Pubmed Lemke MR: [Antidepressant effects of dopamine agonists. Experimental and clinical findings] Nervenarzt. 2007 Jan;78(1):31-8. - Pubmed
DTHybrid score	0.5703

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ: O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. - Pubmed
DTHybrid score	0.6498
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7389
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.512
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4801
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3611

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed Uhr M, Grauer MT, Holsboer F: Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry. 2003 Oct 15;54(8):840-6. - Pubmed Karlsson L, Schmitt U, Josefsson M, Carlsson B, Ahlner J, Bengtsson F, Kugelberg FC, Hiemke C: Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein. Eur Neuropsychopharmacol. 2010 Sep;20(9):632-40. doi: 10.1016/j.euroneuro.2010.04.004. Epub 2010 May 13. - Pubmed
DTHybrid score	0.4981
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inducer
References	Bachmeier CJ, Beaulieu-Abdelahad D, Ganey NJ, Mullan MJ, Levin GM: Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos. 2011 May;32(4):233-44. doi: 10.1002/bdd.753. Epub 2011 Mar 28. - Pubmed
DTHybrid score	0.2458

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.3237
4924	Cytochrome P450 2C8	CYP2C8	0.2771
4118	Cytochrome P450 3A5	CYP3A5	0.2469
6013	Cytochrome P450 2E1	CYP2E1	0.1744
6107	Cytochrome P450 3A7	CYP3A7	0.1739
556	Alpha-1A adrenergic receptor	ADRA1A	0.1393
492	Histamine H1 receptor	HRH1	0.1373
5718	Cytochrome P450 2A6	CYP2A6	0.1188
6024	Cytochrome P450 1A1	CYP1A1	0.1165
587	Serum albumin	ALB	0.111
3941	Amine oxidase [flavin-containing] A	MAOA	0.1063
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1045
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1015
131	Synaptic vesicular amine transporter	SLC18A2	0.0951
3939	Amine oxidase [flavin-containing] B	MAOB	0.0873
318	Alpha-2A adrenergic receptor	ADRA2A	0.087
20	Prostaglandin G/H synthase 1	PTGS1	0.0864
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0864
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0837
632	Alpha-1B adrenergic receptor	ADRA1B	0.0827
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0784
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0778
862	Multidrug resistance-associated protein 1	ABCC1	0.0777
6106	Cytochrome P450 2C18	CYP2C18	0.0726
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0643
6145	Solute carrier family 22 member 1	SLC22A1	0.0639
831	D(2) dopamine receptor	DRD2	0.0638
6144	Solute carrier family 22 member 2	SLC22A2	0.0626
766	Beta-2 adrenergic receptor	ADRB2	0.0594
193	Beta-1 adrenergic receptor	ADRB1	0.0553
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0547
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0539
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0513
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0492
1729	Solute carrier family 22 member 6	SLC22A6	0.0484
617	Muscarinic acetylcholine receptor M2	CHRM2	0.048
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0475
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0472
1898	Cytochrome P450 1B1	CYP1B1	0.047
118	Organic cation/carnitine transporter 2	SLC22A5	0.0464
3811	Cytochrome P450 19A1	CYP19A1	0.0462
776	Bile salt export pump	ABCB11	0.0436
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0435
847	Mu-type opioid receptor	OPRM1	0.0433
6147	Solute carrier family 22 member 3	SLC22A3	0.0429
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0427
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0427
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0424
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0424
23	D(1A) dopamine receptor	DRD1	0.0417
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0417
290	Prostaglandin G/H synthase 2	PTGS2	0.0416
629	Alpha-2B adrenergic receptor	ADRA2B	0.0416
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0399
731	HIV-1 protease	HIV-1 protease	0.0398
3923	Cholinesterase	BCHE	0.0396
467	Delta-type opioid receptor	OPRD1	0.0396
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.039
696	Kappa-type opioid receptor	OPRK1	0.0379
136	Estrogen receptor	ESR1	0.0375
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0355
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.035
789	Alpha-1D adrenergic receptor	ADRA1D	0.0348
1636	Trace amine-associated receptor 1	TAAR1	0.0344
6142	Solute carrier family 22 member 8	SLC22A8	0.0333
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0323
378	Alpha-2C adrenergic receptor	ADRA2C	0.0318
871	Glucocorticoid receptor	NR3C1	0.0317
2164	Multidrug resistance-associated protein 4	ABCC4	0.0317
1656	CYP2B protein	CYP2B	0.0316
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0313
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0309
6182	Cytochrome P450 2J2	CYP2J2	0.0296
260	Cytochrome P450 51	ERG11	0.0295
761	Cytochrome P450 51	ERG11	0.0295
3163	Cytochrome P450 51	cyp51	0.0295
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.029
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0283
817	DNA topoisomerase 2-alpha	TOP2A	0.0281
4120	NADPH--cytochrome P450 reductase	POR	0.0274
844	Epidermal growth factor receptor	EGFR	0.0271
6143	Solute carrier family 22 member 7	SLC22A7	0.0261
468	Cytochrome P450 4A11	CYP4A11	0.0256
122	P2Y purinoceptor 12	P2RY12	0.0251
465	Calmodulin	CALM1	0.0251
6137	Multidrug resistance-associated protein 6	ABCC6	0.0246
504	Mast/stem cell growth factor receptor	KIT	0.0238
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0232
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0231
833	Organic cation/carnitine transporter 1	SLC22A4	0.023
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0221
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0221
6148	Multidrug resistance-associated protein 7	ABCC10	0.0218
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0214
1757	Myeloperoxidase	MPO	0.0213
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0213
638	D(3) dopamine receptor	DRD3	0.0213
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0212
1353	DNA topoisomerase 1	TOP1	0.0207
3552	DNA topoisomerase 1	topA	0.0207
474	Acetylcholinesterase	ACHE	0.0207
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0201
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0198
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0196
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0192
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.019
146	Androgen receptor	AR	0.0188
6031	Cytochrome P450 3A43	CYP3A43	0.0188
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0188
1024	Solute carrier family 22 member 11	SLC22A11	0.0187
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0186
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0185
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0185
1517	Beta-3 adrenergic receptor	ADRB3	0.0184
4604	Liver carboxylesterase 1	CES1	0.0183
891	Dihydropteroate synthase	folP	0.0182
5359	Dihydropteroate synthase	folP	0.0182
7175	Dihydropteroate synthase	sulI	0.0182
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.018
124	Histamine H2 receptor	HRH2	0.0179
70	Type-1 angiotensin II receptor	AGTR1	0.0179
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0178
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0175
6432	Transporter	snf	0.0172
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0172
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0168
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0168
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0165
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0163
407	Vascular endothelial growth factor receptor 2	KDR	0.0163
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0163
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0163
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.016
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0159
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0158
161	Tubulin beta chain	TUBB	0.0156
312	Tubulin beta chain	TUB2	0.0156
869	Estrogen receptor beta	ESR2	0.0155
26	Vascular endothelial growth factor receptor 3	FLT4	0.0155
6136	Multidrug resistance-associated protein 5	ABCC5	0.0155
6220	Aryl hydrocarbon receptor	AHR	0.0154
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
32	Vascular endothelial growth factor receptor 1	FLT1	0.0149
432	D(4) dopamine receptor	DRD4	0.0148
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0148
6141	Sodium/bile acid cotransporter	SLC10A1	0.0147
756	Sex hormone-binding globulin	SHBG	0.0144
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0143
482	Glycine receptor subunit alpha-1	GLRA1	0.0141
614	Progesterone receptor	PGR	0.0141
29	Tubulin beta-1 chain	TUBB1	0.014
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.014
174	Sigma 1-type opioid receptor	SIGMAR1	0.0139
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0139
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0132
818	50S ribosomal protein L10	rplJ	0.013
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
904	Glutathione S-transferase P	GSTP1	0.0128
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0127
380	Cytochrome P450 17A1	CYP17A1	0.0125
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0124
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0123
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0123
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0123
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0123
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0122
94	5-hydroxytryptamine 4 receptor	HTR4	0.0122
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.012
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0119
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0119
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0118
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0118
716	5-hydroxytryptamine 7 receptor	HTR7	0.0118
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0116
373	Transthyretin	TTR	0.0115
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0114
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0114
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0113
3947	Xanthine dehydrogenase/oxidase	XDH	0.0113
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0112
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0112
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0112
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0112
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0111
4773	Deoxycytidine kinase	DCK	0.011
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.011
163	D(1B) dopamine receptor	DRD5	0.011
3810	Catechol O-methyltransferase	COMT	0.0109
1618	High affinity nerve growth factor receptor	NTRK1	0.0108
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0108
952	Dipeptidyl peptidase 4	DPP4	0.0108
811	Translocator protein	TSPO	0.0107
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0106
777	Tumor necrosis factor	TNF	0.0104
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0104
117	Sterol O-acyltransferase 1	SOAT1	0.0104
2539	Tubulin alpha-1 chain	TUBA4A	0.0104
232	Corticosteroid-binding globulin	SERPINA6	0.0103
33	Cystine/glutamate transporter	SLC7A11	0.0103
738	Monocarboxylate transporter 1	SLC16A1	0.0102
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0101
1192	Sulfotransferase 1A1	SULT1A1	0.01
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0099
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0098
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0098
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0098
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0098
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0097
1010	Cytochrome P450 51A1	CYP51A1	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
319	Opioid receptor, sigma 1	OPRS1	0.0096
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0096
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0096
49	Endothelin B receptor	EDNRB	0.0096
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0095
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0095
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0095
68	Cannabinoid receptor 1	CNR1	0.0094
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0093
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0093
992	Protein tyrosine kinase 2 beta	PTK2B	0.0092
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0092
6014	Cytochrome P450 2A13	CYP2A13	0.0092
295	Carbonic anhydrase 1	CA1	0.0092
365	Dihydrofolate reductase	DHFR	0.0091
2381	Dihydrofolate reductase	DFR1	0.0091
2833	Dihydrofolate reductase	Not Available	0.0091
2931	Dihydrofolate reductase	folA	0.0091
3544	Dihydrofolate reductase	folA	0.0091
3682	Dihydrofolate reductase	folA	0.0091
6642	Dihydrofolate reductase	folA	0.0091
6756	Dihydrofolate reductase	dfrA	0.0091
183	Vascular endothelial growth factor A	VEGFA	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
427	Substance-P receptor	TACR1	0.009
5787	Angiopoietin-1 receptor	TEK	0.0089
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0088
165	FL cytokine receptor	FLT3	0.0088
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0086
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0086
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0085
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0085
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0085
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0083
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0081
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0081
6085	Fatty acid-binding protein, intestinal	FABP2	0.008
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.008
2981	Phospholipase A2, membrane associated	PLA2G2A	0.008
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0079
6102	Arylamine N-acetyltransferase 2	NAT2	0.0078
6146	High affinity copper uptake protein 1	SLC31A1	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0078
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
705	Glutamate receptor 1	GRIA1	0.0076
823	Fibroblast growth factor receptor 2	FGFR2	0.0075
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0075
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0075
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0074
1852	Microtubule-associated protein 2	MAP2	0.0074
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
357	Carbonic anhydrase 2	CA2	0.0072
6138	Multidrug resistance protein 3	ABCB4	0.0072
921	Glutamate receptor 2	GRIA2	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
537	ATP synthase delta chain, mitochondrial	ATP5D	0.007
24	Thymidylate synthase	TMP1	0.007
359	Thymidylate synthase	TYMS	0.007
2626	Thymidylate synthase	thyA	0.007
2729	Thymidylate synthase	thyA	0.007
5352	Thymidylate synthase	THYA	0.007
908	Glutathione S-transferase theta-1	GSTT1	0.007
275	Arachidonate 5-lipoxygenase	ALOX5	0.007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.007
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
106	Cannabinoid receptor 2	CNR2	0.0068
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0067
737	Mineralocorticoid receptor	NR3C2	0.0067
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0067
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0066
469	Annexin A1	ANXA1	0.0066
3856	Fibroblast growth factor receptor 3	FGFR3	0.0065
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0064
153	Dopamine beta-hydroxylase	DBH	0.0064
6020	Aldehyde oxidase	AOX1	0.0064
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0063
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
856	Vitamin D3 receptor	VDR	0.0063
133	Dihydropterate synthase	sulI	0.0063
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0062
4237	50S ribosomal protein L22	rplV	0.0062
2449	Tubulin alpha-3 chain	TUBA1A	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0061
239	Coagulation factor X	F10	0.0061
4203	Histamine N-methyltransferase	HNMT	0.0061
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0061
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1360	Sphingomyelin phosphodiesterase	SMPD1	0.006
6126	Carbonic anhydrase 7	CA7	0.006
273	Apoptosis regulator Bcl-2	BCL2	0.0059
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0059
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0058
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0058
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0058
936	Ephrin type-A receptor 2	EPHA2	0.0057
6163	Copper-transporting ATPase 2	ATP7B	0.0057
6165	Copper-transporting ATPase 1	ATP7A	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
7	Nitric oxide synthase, inducible	NOS2	0.0056
563	Thyroid peroxidase	TPO	0.0056
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0056
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0056
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0056
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0055
3932	Glutathione S-transferase A2	GSTA2	0.0055
1629	Transcription factor AP-1	JUN	0.0055
6506	Stathmin-4	STMN4	0.0055
896	Glutathione S-transferase Mu 1	GSTM1	0.0055
3809	Estrogen-related receptor gamma	ESRRG	0.0055
581	Cytochrome P450 2R1	CYP2R1	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
84	Nuclear receptor 0B1	NR0B1	0.0053
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0053
1178	Adenosine A2a receptor	ADORA2A	0.0053
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0053
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
1650	Heme carrier protein 1	SLC46A1	0.0053
5923	Microtubule-associated protein tau	MAPT	0.0053
5924	Microtubule-associated protein 4	MAP4	0.0053
828	Phenylalanine-4-hydroxylase	PAH	0.0052
3109	Phenylalanine-4-hydroxylase	phhA	0.0052
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0052
814	Ryanodine receptor 1	RYR1	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
780	Retinoic acid receptor RXR-gamma	RXRG	0.0049
4103	Proteasome subunit beta type 2	PSMB2	0.0049
4102	Proteasome subunit beta type 5	PSMB5	0.0049
4101	Proteasome subunit beta type 1	PSMB1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
1275	Estrogen sulfotransferase	SULT1E1	0.0048
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0047
683	Potassium transporter	GK0582	0.0047
284	DNA-directed RNA polymerase beta chain	rpoB	0.0047
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0047
565	Extracellular calcium-sensing receptor	CASR	0.0046
1630	Integrin beta-2	ITGB2	0.0045
54	Prothrombin	F2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6149	Solute carrier family 22 member 10	SLC22A10	0.0045
88	Retinoic acid receptor RXR-beta	RXRB	0.0045
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0044
6824	Tyrosine-protein kinase Lyn	LYN	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5798	Mitogen-activated protein kinase 11	MAPK11	0.0044
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0043
518	Peroxidase/catalase T	katG	0.0043
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0043
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0043
4122	Histone deacetylase 2	HDAC2	0.0042
4217	Telomerase reverse transcriptase	TERT	0.0042
1992	Vitamin D-binding protein	GC	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0042
6043	Putative G-protein coupled receptor 44	GPR44	0.0041
4192	DNA topoisomerase 2-beta	TOP2B	0.0041
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0041
1050	Bile salt sulfotransferase	SULT2A1	0.0041
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.004
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.004
6174	50S ribosomal protein L32	rpmF	0.004
459	Retinoic acid receptor RXR-alpha	RXRA	0.004
1262	Corticotropin-lipotropin	POMC	0.004
1541	Metalloproteinase	mmp20	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0038
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0038
1760	Aminopeptidase N	ANPEP	0.0038
6843	Aminopeptidase N	pepN	0.0038
85	Growth hormone receptor	GHR	0.0038
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0037
6167	Organic solute transporter subunit beta	OSTB	0.0037
6166	Organic solute transporter subunit alpha	OSTA	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
1864	RET proto-oncogene	RET	0.0037
2599	Tyrosine-protein kinase HCK	HCK	0.0036
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0036
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0036
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
634	Squalene monooxygenase	SQLE	0.0035
7196	Squalene monooxygenase	ERG1	0.0035
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
939	50S ribosomal protein L3	rplC	0.0035
293	Gamma-glutamyl hydrolase	GGH	0.0035
4311	tRNA	TRDMT1	0.0035
4325	tRNA	trmD	0.0035
4328	tRNA	trmD	0.0035
164	Histamine H4 receptor	HRH4	0.0035
2216	Fibroblast growth factor receptor 4	FGFR4	0.0034
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0033
558	Solute carrier family 12 member 1	SLC12A1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
291	Nitric-oxide synthase, endothelial	NOS3	0.0033
2320	Thymidine kinase, cytosolic	TK1	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0033
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0033
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
976	Platelet glycoprotein IX	GP9	0.0032
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0032
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0032
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0032
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0031
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0031
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0031
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0031
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0031
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0031
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3639	Thymidine phosphorylase	deoA	0.0031
3936	Thymidine phosphorylase	TYMP	0.0031
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.003
5934	Cytochrome P450 26A1	CYP26A1	0.003
702	UMP-CMP kinase	CMPK1	0.003
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.003
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.003
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.003
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0029
6151	Monocarboxylate transporter 10	SLC16A10	0.0029
1196	Complement decay-accelerating factor	CD55	0.0029
444	Alcohol dehydrogenase 1B	ADH1B	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0029
251	Alcohol dehydrogenase 1A	ADH1A	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
3937	Fatty-acid amide hydrolase	FAAH	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0028
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0027
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0027
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0026
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0026
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0026
6044	Serum paraoxonase/lactonase 3	PON3	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6168	Solute carrier family 22 member 16	SLC22A16	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
489	Monocarboxylate transporter 2	SLC16A7	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6837	Serine/threonine-protein kinase 17B	STK17B	0.0025
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0025
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0025
572	Integrin alpha-L	ITGAL	0.0025
760	Fibroblast growth factor 1	FGF1	0.0024
517	Alcohol dehydrogenase 1C	ADH1C	0.0024
1648	Elastin	ELN	0.0024
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
751	Potassium channel subfamily K member 6	KCNK6	0.0024
267	Plasminogen activator inhibitor 1	SERPINE1	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4226	Uridine phosphorylase 2	UPP2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
3086	Plasmepsin-2	Not Available	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
6228	Nuclear receptor coactivator 1	NCOA1	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
172	Potassium channel subfamily K member 1	KCNK1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0022
4225	Uridine phosphorylase 1	UPP1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
6221	Steroid hormone receptor ERR1	ESRRA	0.0022
3404	Exotoxin A	eta	0.0022
2232	Interleukin-5	IL5	0.0022
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0021
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1039	Histone deacetylase 9	HDAC9	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6048	Troponin C, skeletal muscle	TNNC2	0.0021
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
162	Retinoic acid receptor gamma-1	RARG	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
5626	Nucleoside diphosphate kinase B	NME2	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
413	Amidophosphoribosyltransferase	PPAT	0.002
2515	Amidophosphoribosyltransferase	purF	0.002
3714	Amidophosphoribosyltransferase	purF	0.002
76	Nitric-oxide synthase, brain	NOS1	0.002
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
1058	Cell division protein kinase 5	CDK5	0.002
2207	Rhodopsin	RHO	0.002
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
3957	Adenosine deaminase	ADA	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0018
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0018
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0018
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
2021	Thrombomodulin	THBD	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
3587	Gastrotropin	FABP6	0.0017
6218	Pannexin-1	PANX1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
5294	Nucleoside diphosphate kinase A	NME1	0.0017
3830	Calreticulin	CALR	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0016
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
268	Adenosine A2b receptor	ADORA2B	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3221	Cytochrome c4	cc4	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
2298	Cytochrome P450-cam	camC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1507	Cytochrome c	CYCS	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4943	Cytochrome c6	petJ	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
5000	HemO	hemO	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4972	P450cin	cinA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3093	Catalase HPII	katE	0.0006
4952	Catalase/peroxidase	katA	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00285 - Venlafaxine

Targets

Enzymes

Transporters

Predictions