DT-Web

DB01072 - Atazanavir


Identification
Name Atazanavir
Accession Number DB01072 (APRD00804)
Type small molecule
Description Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications. The U.S. Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 704.8555
Groups approved
Monoisotopic Weight 704.389748048
Pharmacology
Indication Used in combination with other antiretroviral agents for the treatment of HIV-1 infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission.
Mechanism of action Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir is not active against HIV-2.
Absorption Atazanavir is rapidly absorbed with a Tmax of approximately 2.5 hours. Administration of atazanavir with food enhances bioavailability and reduces pharmacokinetic variability. Oral bioavailability is 60-68%.
Protein binding 86% bound to human serum proteins (alpha-1-acid glycoprotein and albumin). Protein binding is independent of concentration.
Biotransformation Atazanavir is extensively metabolized in humans, primarily by the liver. The major biotransformation pathways of atazanavir in humans consisted of monooxygenation and dioxygenation. Other minor biotransformation pathways for atazanavir or its metabolites consisted of glucuronidation, N-dealkylation, hydrolysis, and oxygenation with dehydrogenation. In vitro studies using human liver microsomes suggested that atazanavir is metabolized by CYP3A.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Abacavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Atazanavir. The antiviral response should be closely monitored.
Abiraterone Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol The protease inhibitor, atazanavir, may increase the anticoagulant effect of acenocoumarol.
Aluminium This gastric pH modifier decreases the levels/effects of atazanavir
Amiodarone Increased risk of cardiotoxicity and arrhythmias.
Amitriptyline Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if atazanavir if initiated, discontinued or dose changed.
Amoxapine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amoxapine if atazanavir if initiated, discontinued or dose changed.
Anisindione The protease inhibitor, atazanavir, may increase the anticoagulant effect of anisindione.
Atorvastatin Atazanavir may increase the serum concentration of atorvastatin by decreasing its metabolism. Concomitant therapy is contraindicated.
Bepridil Atazanavir may increase the effect and toxicity of bepridil.
Bismuth Subsalicylate This gastric pH modifier decreases the levels/effects of atazanavir
Bromazepam Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if atazanavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Buprenorphine Atazanavir may increase the serum concentration of Buprenorphine. Buprenorphine may decrease the serum concentration of Atazanavir. Avoid use of buprenorphine in patients receiving atazanavir without ritonavir boosting due to possible decreases in atazanavir exposure. In patients receiving buprenorphine with atazanavir/ritonavir, monitor for increased buprenorphine effects and consider dose reductions if patients experience adverse effects.
Cabazitaxel Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Calcium This gastric pH modifier decreases the levels/effects of atazanavir
Cimetidine This gastric pH modifier decreases the levels/effects of atazanavir
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Atazanavir may increase serum level of clarithromycin.
Clomipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if atazanavir is initiated, discontinued or dose changed.
Cyclosporine Atazanavir may increase the therapeutic and adverse effects of cyclosporine.
Dantrolene Atazanavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if atazanavir is initiated, discontinued or dose changed.
Desipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if atazanavir is initiated, discontinued or dose changed.
Dicumarol The protease inhibitor, atazanavir, may increase the anticoagulant effect of dicumarol.
Dihydroergotamine Atazanavir may increase the therapeutic and adverse effects of dihydroergotamine.
Dihydroquinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Dihydroxyaluminium This gastric pH modifier decreases the levels/effects of atazanavir
Diltiazem Atazanavir may increase the therapeutic and adverse effects of diltiazem resulting in increased risk of AV block. Consider alternate therapy, a 50% dose reduction of diltiazem and monitor for changes in the therapeutic and adverse effects of diltiazem if atazanavir is initiated, discontinued or dose changed.
Doxepin Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if atazanavir if initiated, discontinued or dose changed.
Efavirenz Efavirenz decreases the levels/effects of atazanavir
Eltrombopag Decreases metabolism, will increase effect/level of eltrombopag. UDP-glucuronosyltransferase inhibition.
Ergotamine Atazanavir may increase the effect and toxicity of ergotamine.
Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Esomeprazole This gastric pH modifier decreases the levels/effects of atazanavir
Etravirine Atazanavir, when administered concomitantly with etravirine, may experience a decrease in serum concentrations. Etravirine, when administered concomitantly with Atazanavir, may expereince an increase in serum concentrations. Recommended to avoid use of this combination.
Famotidine This gastric pH modifier decreases the levels/effects of atazanavir
Imipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if atazanavir if initiated, discontinued or dose changed.
Indinavir Increased risk of hyperbilirubinemia with this association
Irinotecan Increases levels/effect of irinotecan
Lansoprazole This gastric pH modifier decreases the levels/effects of atazanavir
Lidocaine Increased risk of cardiotoxicity and arrhythmias
Lovastatin Atazanavir may increase the effect and toxicity of lovastatin. Concomitant therapy is contraindicated.
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Magnesium This gastric pH modifier decreases the levels/effects of atazanavir
Magnesium oxide This gastric pH modifier decreases the levels/effects of atazanavir
Magnesium Sulfate This gastric pH modifier decreases the levels/effects of atazanavir
Methylergonovine Increases the effect and toxicity of ergot derivative
Midazolam Atazanavir may increase the effect and toxicity of the benzodiazepine, midazolam.
Nevirapine Nevirapine, a strong CYP3A4 inducer, may decrease the serum concentration of atazanavir by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of atazanavir if nevirapine is initiated, discontinued or dose changed.
Nizatidine This gastric pH modifier decreases the levels/effects of atazanavir
Nortriptyline Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if atazanavir if initiated, discontinued or dose changed.
Omeprazole This gastric pH modifier decreases the levels/effects of atazanavir
Pantoprazole This gastric pH modifier decreases the levels/effects of atazanavir
Pimozide The protease inhibitor, atazanavir, may increase the effect and toxicity of pimozide.
Pitavastatin Increases serum concentration of pitavastatin and the potential for adverse drug reactions. Avoid concomitant drug therapy.
Protriptyline Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if atazanavir if initiated, discontinued or dose changed.
Quinidine Increased risk of cardiotoxicity and arrhythmias.
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Rabeprazole Rabeprazole may decrease the serum levels and therapeutic effects of atazanavir.
Ramelteon Atazanavir increases levels/toxicity of ramelteon
Ranitidine Ranitidine may decrease the levels/effects of atazanavir.
Ranolazine Atazanavir, a strong CYP3A4 inhibitor, may increase the serum level of ranolazine. Concomitant therapy is contraindicated.
Rifabutin Atazanavir may increase levels/toxicity of rifabutin.
Rifampin Rifampin reduces levels and efficacy of atazanavir
Ritonavir Association with dose adjustment
Sildenafil Increases the effect and toxicity of sildenafil
Simvastatin Increased risk of myopathy/rhabdomyolysis
Sirolimus Increases the effect and toxicity of immunosuppressant
Sodium bicarbonate This gastric pH modifier decreases the levels/effect of atazanavir
St. John's Wort St. John's Wort decreases the levels/effects of atazanavir
Sunitinib Possible increase in sunitinib levels
Tacrolimus The protease inhibitor, Atazanavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Atazanavir therapy is initiated, discontinued or altered.
Tadalafil Atazanavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Atazanavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin Atazanvir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Atazanavir is initiated, discontinued, or dose changed.
Telithromycin Co-administration may result in altered plasma concentrations of Atazanavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents.
Temsirolimus Atazanavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Atazanavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Atazanavir is initiated, discontinued or dose changed.
Tenofovir Concomitant therapy may result in decreased serum levels of Atazanavir and increased levels of Tenofovir. Concomitant therapy should only be used with the inclusion of Ritonavir.
Tiagabine The strong CYP3A4 inhibitor, Atazanavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Atazanavir is initiated, discontinued or dose changed.
Tipranavir Tipranavir, co-administered with Ritonavir, may decrease the plasma concentration of Atazanavir. Consider alternate therapy.
Tolterodine Atazanavir may decrease the metabolism and clearance of Tolterodine. Adjust the Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Atazanavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The protease inhibitor, Atazanavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Atazanavir is initiated, discontinued or dose changed.
Tretinoin The strong CYP2C8 inhibitor, Atazanavir, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Atazanavir is initiated, discontinued to dose changed.
Triazolam Atazanavir may increase the effect and toxicity of the benzodiazepine, triazolam.
Trimipramine The strong CYP3A4 inhibitor, Atazanavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Atazanavir is initiated, discontinued or dose changed.
Vardenafil Atazanavir, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Vemurafenib Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine Atazanavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Atazanavir is initiated, discontinued, or dose changed.
Verapamil Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Atazanavir is initiated, discontinued or dose changed.
Vilazodone CYP3A4 Inhibitors (Strong) may increase the serum concentration of Vilazodone. imit maximum adult vilazodone dose to 20 mg/day in patients receiving strong CYP3A4 inhibitors.
Vinblastine Atazanavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Atazanavir is initiated, discontinued or dose changed.
Vincristine Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Atazanavir is initiated, discontinued or dose changed.
Vinorelbine Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Atazanavir is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of atazanavir by decreasing its metabolism. The serum concentration of voriconazole may be increased by atazanavir. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Warfarin The protease inhibitor, atazanavir, may increase the anticoagulant effect of warfarin.
Zolpidem Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if atazanavir is initiated, discontinued or dose changed.
Zonisamide Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if atazanavir is initiated, discontinued or dose changed.
Zopiclone Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if atazanavir is initiated, discontinued or dose changed.
Food Interactions
  • Administration with food reduces pharmacokinetic variability.
  • Food increases product absorption.

Targets


HIV-1 protease
Name HIV-1 protease
Gene Name HIV-1 protease
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Dierynck I, De Wit M, Gustin E, Keuleers I, Vandersmissen J, Hallenberger S, Hertogs K: Binding kinetics of darunavir to HIV-1 protease explain the potent antiviral activity and high genetic barrier. J Virol. 2007 Oct 10;. - Pubmed
  • Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Next Generation Protease Inhibitor of Human Immunodeficiency Virus Type 1. Antimicrob Agents Chemother. 2007 Jul 16;. - Pubmed
  • Wood R: Atazanavir: its role in HIV treatment. Expert Rev Anti Infect Ther. 2008 Dec;6(6):785-96. - Pubmed
  • Le Tiec C, Barrail A, Goujard C, Taburet AM: Clinical pharmacokinetics and summary of efficacy and tolerability of atazanavir. Clin Pharmacokinet. 2005;44(10):1035-50. - Pubmed
  • Pyrko P, Kardosh A, Wang W, Xiong W, Schonthal AH, Chen TC: HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 2007 Nov 15;67(22):10920-8. - Pubmed
  • Menendez-Arias L, Tozser J: HIV-1 protease inhibitors: effects on HIV-2 replication and resistance. Trends Pharmacol Sci. 2008 Jan;29(1):42-9. Epub 2007 Dec 4. - Pubmed
  • Lopez-Cortes LF: [Pharmacology, pharmacokinetic features and interactions of atazanavir] Enferm Infecc Microbiol Clin. 2008 Dec;26 Suppl 17:2-8. - Pubmed
  • Busti AJ, Hall RG, Margolis DM: Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy. 2004 Dec;24(12):1732-47. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3234

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Le Tiec C, Barrail A, Goujard C, Taburet AM: Clinical pharmacokinetics and summary of efficacy and tolerability of atazanavir. Clin Pharmacokinet. 2005;44(10):1035-50. - Pubmed
  • Busti AJ, Hall RG, Margolis DM: Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy. 2004 Dec;24(12):1732-47. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5089
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Busti AJ, Hall RG, Margolis DM: Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy. 2004 Dec;24(12):1732-47. - Pubmed
DTHybrid score 0.3184

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Perloff ES, Duan SX, Skolnik PR, Greenblatt DJ, von Moltke LL: Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro. Drug Metab Dispos. 2005 Jun;33(6):764-70. Epub 2005 Mar 11. - Pubmed
  • Lucia MB, Golotta C, Rutella S, Rastrelli E, Savarino A, Cauda R: Atazanavir inhibits P-glycoprotein and multidrug resistance-associated protein efflux activity. J Acquir Immune Defic Syndr. 2005 Aug 15;39(5):635-7. - Pubmed
  • Chinn LW, Gow JM, Tse MM, Becker SL, Kroetz DL: Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein. J Antimicrob Chemother. 2007 Jul;60(1):61-7. Epub 2007 May 17. - Pubmed
  • Wood R: Atazanavir: its role in HIV treatment. Expert Rev Anti Infect Ther. 2008 Dec;6(6):785-96. - Pubmed
  • Janneh O, Anwar T, Jungbauer C, Kopp S, Khoo SH, Back DJ, Chiba P: P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir. Antivir Ther. 2009;14(7):965-74. - Pubmed
  • Storch CH, Theile D, Lindenmaier H, Haefeli WE, Weiss J: Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein. Biochem Pharmacol. 2007 May 15;73(10):1573-81. Epub 2007 Jan 24. - Pubmed
DTHybrid score 0.3591
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate,inhibitor
References
  • Janneh O, Anwar T, Jungbauer C, Kopp S, Khoo SH, Back DJ, Chiba P: P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir. Antivir Ther. 2009;14(7):965-74. - Pubmed
  • Lucia MB, Golotta C, Rutella S, Rastrelli E, Savarino A, Cauda R: Atazanavir inhibits P-glycoprotein and multidrug resistance-associated protein efflux activity. J Acquir Immune Defic Syndr. 2005 Aug 15;39(5):635-7. - Pubmed
DTHybrid score 0.2128

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2004
6016 Cytochrome P450 2C19 CYP2C19 0.1976
4118 Cytochrome P450 3A5 CYP3A5 0.155
4924 Cytochrome P450 2C8 CYP2C8 0.1535
4200 Cytochrome P450 1A2 CYP1A2 0.1401
6030 Cytochrome P450 2B6 CYP2B6 0.1096
6107 Cytochrome P450 3A7 CYP3A7 0.1081
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1035
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0832
6013 Cytochrome P450 2E1 CYP2E1 0.075
587 Serum albumin ALB 0.0693
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0688
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0657
6024 Cytochrome P450 1A1 CYP1A1 0.0522
20 Prostaglandin G/H synthase 1 PTGS1 0.0514
5718 Cytochrome P450 2A6 CYP2A6 0.0454
6145 Solute carrier family 22 member 1 SLC22A1 0.0447
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0443
1729 Solute carrier family 22 member 6 SLC22A6 0.0415
776 Bile salt export pump ABCB11 0.0389
817 DNA topoisomerase 2-alpha TOP2A 0.0358
290 Prostaglandin G/H synthase 2 PTGS2 0.0325
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0305
492 Histamine H1 receptor HRH1 0.0297
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0296
871 Glucocorticoid receptor NR3C1 0.029
136 Estrogen receptor ESR1 0.0283
1898 Cytochrome P450 1B1 CYP1B1 0.0281
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0279
2164 Multidrug resistance-associated protein 4 ABCC4 0.0277
6144 Solute carrier family 22 member 2 SLC22A2 0.027
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0269
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0267
6142 Solute carrier family 22 member 8 SLC22A8 0.0267
6106 Cytochrome P450 2C18 CYP2C18 0.0258
3811 Cytochrome P450 19A1 CYP19A1 0.0256
824 Sodium-dependent serotonin transporter SLC6A4 0.0256
6137 Multidrug resistance-associated protein 6 ABCC6 0.0254
118 Organic cation/carnitine transporter 2 SLC22A5 0.0241
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0241
6143 Solute carrier family 22 member 7 SLC22A7 0.0239
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0238
556 Alpha-1A adrenergic receptor ADRA1A 0.0231
6148 Multidrug resistance-associated protein 7 ABCC10 0.0208
502 5-hydroxytryptamine 2A receptor HTR2A 0.0204
831 D(2) dopamine receptor DRD2 0.0202
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0197
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0178
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0175
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0174
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0174
6147 Solute carrier family 22 member 3 SLC22A3 0.0169
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0164
847 Mu-type opioid receptor OPRM1 0.0164
1024 Solute carrier family 22 member 11 SLC22A11 0.0163
614 Progesterone receptor PGR 0.0159
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0157
3923 Cholinesterase BCHE 0.0157
318 Alpha-2A adrenergic receptor ADRA2A 0.0155
161 Tubulin beta chain TUBB 0.0154
312 Tubulin beta chain TUB2 0.0154
766 Beta-2 adrenergic receptor ADRB2 0.0149
260 Cytochrome P450 51 ERG11 0.0149
761 Cytochrome P450 51 ERG11 0.0149
3163 Cytochrome P450 51 cyp51 0.0149
320 5-hydroxytryptamine 1A receptor HTR1A 0.0148
6141 Sodium/bile acid cotransporter SLC10A1 0.0147
632 Alpha-1B adrenergic receptor ADRA1B 0.0147
122 P2Y purinoceptor 12 P2RY12 0.0146
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0145
467 Delta-type opioid receptor OPRD1 0.0144
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0143
29 Tubulin beta-1 chain TUBB1 0.014
193 Beta-1 adrenergic receptor ADRB1 0.0139
4604 Liver carboxylesterase 1 CES1 0.0132
23 D(1A) dopamine receptor DRD1 0.0131
3307 Acriflavine resistance protein B acrB 0.013
6136 Multidrug resistance-associated protein 5 ABCC5 0.0129
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0128
696 Kappa-type opioid receptor OPRK1 0.0127
6599 HTH-type transcriptional regulator ttgR ttgR 0.0126
952 Dipeptidyl peptidase 4 DPP4 0.0126
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0125
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0125
590 5-hydroxytryptamine 2C receptor HTR2C 0.0123
833 Organic cation/carnitine transporter 1 SLC22A4 0.0122
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0121
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.012
844 Epidermal growth factor receptor EGFR 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
70 Type-1 angiotensin II receptor AGTR1 0.0118
341 5-hydroxytryptamine 3 receptor HTR3A 0.0116
891 Dihydropteroate synthase folP 0.0116
5359 Dihydropteroate synthase folP 0.0116
7175 Dihydropteroate synthase sulI 0.0116
789 Alpha-1D adrenergic receptor ADRA1D 0.0115
713 Sodium-dependent dopamine transporter SLC6A3 0.0113
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0112
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0112
477 DNA topoisomerase 4 subunit A parC 0.0111
886 DNA topoisomerase 4 subunit A parC 0.0111
6226 DNA topoisomerase 4 subunit A parC 0.0111
6182 Cytochrome P450 2J2 CYP2J2 0.0111
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0111
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.011
380 Cytochrome P450 17A1 CYP17A1 0.011
404 DNA gyrase subunit A gyrA 0.011
6224 DNA gyrase subunit A gyrA 0.011
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0109
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0109
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0108
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0107
869 Estrogen receptor beta ESR2 0.0105
468 Cytochrome P450 4A11 CYP4A11 0.0105
4120 NADPH--cytochrome P450 reductase POR 0.0104
738 Monocarboxylate transporter 1 SLC16A1 0.0103
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0103
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.01
6031 Cytochrome P450 3A43 CYP3A43 0.01
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0098
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
723 Cytosolic phospholipase A2 PLA2G4A 0.0097
4237 50S ribosomal protein L22 rplV 0.0097
3941 Amine oxidase [flavin-containing] A MAOA 0.0097
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0097
465 Calmodulin CALM1 0.0096
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0096
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0094
885 5-hydroxytryptamine 1B receptor HTR1B 0.0094
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
6085 Fatty acid-binding protein, intestinal FABP2 0.0091
6138 Multidrug resistance protein 3 ABCB4 0.009
629 Alpha-2B adrenergic receptor ADRA2B 0.0088
146 Androgen receptor AR 0.0088
3939 Amine oxidase [flavin-containing] B MAOB 0.0088
1852 Microtubule-associated protein 2 MAP2 0.0086
725 5-hydroxytryptamine 1D receptor HTR1D 0.0086
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0086
4238 50S ribosomal protein L4 rplD 0.0085
5578 50S ribosomal protein L4 rplD 0.0085
6173 50S ribosomal protein L4 rplD 0.0085
6219 50S ribosomal protein L4 rplD 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
474 Acetylcholinesterase ACHE 0.0084
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0083
638 D(3) dopamine receptor DRD3 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.0082
1353 DNA topoisomerase 1 TOP1 0.0082
3552 DNA topoisomerase 1 topA 0.0082
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0081
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.008
273 Apoptosis regulator Bcl-2 BCL2 0.008
2449 Tubulin alpha-3 chain TUBA1A 0.008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0079
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0079
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0078
373 Transthyretin TTR 0.0078
504 Mast/stem cell growth factor receptor KIT 0.0077
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0077
811 Translocator protein TSPO 0.0076
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0076
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0075
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0075
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0075
124 Histamine H2 receptor HRH2 0.0074
756 Sex hormone-binding globulin SHBG 0.0073
3947 Xanthine dehydrogenase/oxidase XDH 0.0073
183 Vascular endothelial growth factor A VEGFA 0.0073
407 Vascular endothelial growth factor receptor 2 KDR 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0071
737 Mineralocorticoid receptor NR3C2 0.0069
49 Endothelin B receptor EDNRB 0.0069
1192 Sulfotransferase 1A1 SULT1A1 0.0069
3810 Catechol O-methyltransferase COMT 0.0069
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0069
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0069
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0069
378 Alpha-2C adrenergic receptor ADRA2C 0.0069
777 Tumor necrosis factor TNF 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0068
1050 Bile salt sulfotransferase SULT2A1 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0067
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0067
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0067
5923 Microtubule-associated protein tau MAPT 0.0066
5924 Microtubule-associated protein 4 MAP4 0.0066
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0066
295 Carbonic anhydrase 1 CA1 0.0066
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
461 Glycine receptor subunit alpha-3 GLRA3 0.0065
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0064
1629 Transcription factor AP-1 JUN 0.0064
365 Dihydrofolate reductase DHFR 0.0064
2381 Dihydrofolate reductase DFR1 0.0064
2833 Dihydrofolate reductase Not Available 0.0064
2931 Dihydrofolate reductase folA 0.0064
3544 Dihydrofolate reductase folA 0.0064
3682 Dihydrofolate reductase folA 0.0064
6642 Dihydrofolate reductase folA 0.0064
6756 Dihydrofolate reductase dfrA 0.0064
2539 Tubulin alpha-1 chain TUBA4A 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0063
133 Dihydropterate synthase sulI 0.0063
24 Thymidylate synthase TMP1 0.0063
359 Thymidylate synthase TYMS 0.0063
2626 Thymidylate synthase thyA 0.0063
2729 Thymidylate synthase thyA 0.0063
5352 Thymidylate synthase THYA 0.0063
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0063
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0062
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.006
716 5-hydroxytryptamine 7 receptor HTR7 0.006
5787 Angiopoietin-1 receptor TEK 0.006
6220 Aryl hydrocarbon receptor AHR 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
992 Protein tyrosine kinase 2 beta PTK2B 0.0059
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0059
6149 Solute carrier family 22 member 10 SLC22A10 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0058
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0058
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0058
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0058
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0058
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
1656 CYP2B protein CYP2B 0.0056
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
68 Cannabinoid receptor 1 CNR1 0.0055
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0054
432 D(4) dopamine receptor DRD4 0.0054
228 Beta platelet-derived growth factor receptor PDGFRB 0.0053
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0053
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0053
275 Arachidonate 5-lipoxygenase ALOX5 0.0053
4192 DNA topoisomerase 2-beta TOP2B 0.0052
427 Substance-P receptor TACR1 0.0051
6043 Putative G-protein coupled receptor 44 GPR44 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.005
357 Carbonic anhydrase 2 CA2 0.005
6102 Arylamine N-acetyltransferase 2 NAT2 0.005
158 Sodium channel protein type 1 subunit alpha SCN1A 0.005
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0049
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0049
284 DNA-directed RNA polymerase beta chain rpoB 0.0048
5773 DNA-directed RNA polymerase beta chain rpoB 0.0048
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0048
904 Glutathione S-transferase P GSTP1 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
4773 Deoxycytidine kinase DCK 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0046
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0046
814 Ryanodine receptor 1 RYR1 0.0045
54 Prothrombin F2 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6167 Organic solute transporter subunit beta OSTB 0.0045
6166 Organic solute transporter subunit alpha OSTA 0.0045
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0045
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0045
6212 Tubulin gamma-1 chain TUBG1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
6020 Aldehyde oxidase AOX1 0.0044
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0044
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0044
130 Prostacyclin synthase PTGIS 0.0044
33 Cystine/glutamate transporter SLC7A11 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0043
2599 Tyrosine-protein kinase HCK HCK 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
4203 Histamine N-methyltransferase HNMT 0.0041
780 Retinoic acid receptor RXR-gamma RXRG 0.0041
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1010 Cytochrome P450 51A1 CYP51A1 0.0041
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0041
856 Vitamin D3 receptor VDR 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
6014 Cytochrome P450 2A13 CYP2A13 0.0039
1541 Metalloproteinase mmp20 0.0039
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
1757 Myeloperoxidase MPO 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
88 Retinoic acid receptor RXR-beta RXRB 0.0038
489 Monocarboxylate transporter 2 SLC16A7 0.0038
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0037
908 Glutathione S-transferase theta-1 GSTT1 0.0037
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0037
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
239 Coagulation factor X F10 0.0036
702 UMP-CMP kinase CMPK1 0.0036
482 Glycine receptor subunit alpha-1 GLRA1 0.0036
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0036
319 Opioid receptor, sigma 1 OPRS1 0.0036
1178 Adenosine A2a receptor ADORA2A 0.0035
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0035
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
3809 Estrogen-related receptor gamma ESRRG 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
528 5-hydroxytryptamine 1E receptor HTR1E 0.0035
939 50S ribosomal protein L3 rplC 0.0035
921 Glutamate receptor 2 GRIA2 0.0035
3932 Glutathione S-transferase A2 GSTA2 0.0034
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0034
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0033
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
3587 Gastrotropin FABP6 0.0033
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0033
6837 Serine/threonine-protein kinase 17B STK17B 0.0033
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0033
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0033
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0031
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0031
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2021 Thrombomodulin THBD 0.0031
705 Glutamate receptor 1 GRIA1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
5251 Carbonyl reductase [NADPH] 1 CBR1 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.003
342 P protein [Includes: DNA-directed DNA polymerase P 0.003
612 P protein [Includes: DNA-directed DNA polymerase P 0.003
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0029
1618 High affinity nerve growth factor receptor NTRK1 0.0029
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0029
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0029
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
6218 Pannexin-1 PANX1 0.0028
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0028
1256 5-hydroxytryptamine 6 receptor HTR6 0.0028
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0028
165 FL cytokine receptor FLT3 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0027
4122 Histone deacetylase 2 HDAC2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
16 Adenosine A1 receptor ADORA1 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
6174 50S ribosomal protein L32 rpmF 0.0027
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
5626 Nucleoside diphosphate kinase B NME2 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
823 Fibroblast growth factor receptor 2 FGFR2 0.0026
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0026
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
511 5-hydroxytryptamine 1F receptor HTR1F 0.0026
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0026
7 Nitric oxide synthase, inducible NOS2 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0025
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0025
605 Fumarate reductase flavoprotein subunit frdA 0.0025
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0025
3673 Fumarate reductase flavoprotein subunit fccA 0.0025
4912 Fumarate reductase flavoprotein subunit ifcA 0.0025
6549 Fumarate reductase flavoprotein subunit frdA 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0025
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0025
1313 Lactoylglutathione lyase GLO1 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
1648 Elastin ELN 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0023
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0023
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0023
6042 Prostaglandin reductase 2 PTGR2 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
469 Annexin A1 ANXA1 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
1792 Tissue-type plasminogen activator PLAT 0.0021
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0021
164 Histamine H4 receptor HRH4 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0021
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
6432 Transporter snf 0.002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.002
896 Glutathione S-transferase Mu 1 GSTM1 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
6168 Solute carrier family 22 member 16 SLC22A16 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
936 Ephrin type-A receptor 2 EPHA2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
5818 Folate receptor alpha FOLR1 0.0019
518 Peroxidase/catalase T katG 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0018
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0018
4041 Microsomal glutathione S-transferase 2 MGST2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
84 Nuclear receptor 0B1 NR0B1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6146 High affinity copper uptake protein 1 SLC31A1 0.0018
1630 Integrin beta-2 ITGB2 0.0018
976 Platelet glycoprotein IX GP9 0.0018
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
1374 Natriuretic peptides B NPPB 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1196 Complement decay-accelerating factor CD55 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
293 Gamma-glutamyl hydrolase GGH 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
3917 Methylenetetrahydrofolate reductase MTHFR 0.0016
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0016
563 Thyroid peroxidase TPO 0.0016
2183 Fatty acid-binding protein, adipocyte FABP4 0.0016
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
174 Sigma 1-type opioid receptor SIGMAR1 0.0016
3957 Adenosine deaminase ADA 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
3233 Bile acid receptor NR1H4 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
634 Squalene monooxygenase SQLE 0.0015
7196 Squalene monooxygenase ERG1 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4031 Glutathione S-transferase A1 GSTA1 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
1341 Histamine H3 receptor HRH3 0.0014
2808 Chloramphenicol acetyltransferase 3 cat3 0.0014
1650 Heme carrier protein 1 SLC46A1 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0014
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
572 Integrin alpha-L ITGAL 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
162 Retinoic acid receptor gamma-1 RARG 0.0013
2320 Thymidine kinase, cytosolic TK1 0.0013
2417 Chloramphenicol acetyltransferase cat 0.0013
3278 Chloramphenicol acetyltransferase cat 0.0013
3808 Dihydropteroate synthase 2 folP2 0.0013
3601 Dihydropteroate synthase 1 folP1 0.0013
3807 Dihydropteroate synthase 1 folP1 0.0013
2810 Dr hemagglutinin structural subunit draA 0.0013
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0013
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
444 Alcohol dehydrogenase 1B ADH1B 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
1992 Vitamin D-binding protein GC 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
4311 tRNA TRDMT1 0.0011
4325 tRNA trmD 0.0011
4328 tRNA trmD 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
3221 Cytochrome c4 cc4 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
2207 Rhodopsin RHO 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
1928 Leukotriene C4 synthase LTC4S 0.001
4043 Glutaredoxin-2, mitochondrial GLRX2 0.001
4034 Glutaredoxin-1 GLRX 0.001
910 Epididymal secretory glutathione peroxidase GPX5 0.001
4036 Glutathione peroxidase 6 GPX6 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4029 Microsomal glutathione S-transferase 3 MGST3 0.001
900 Glutathione S-transferase A4 GSTA4 0.001
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.001
911 Glutathione peroxidase 3 GPX3 0.001
4040 Glutathione peroxidase 7 GPX7 0.001
907 Glutathione peroxidase 2 GPX2 0.001
4032 Microsomal glutathione S-transferase 1 MGST1 0.001
906 Glutathione peroxidase 1 GPX1 0.001
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.001
4035 Glutathione S-transferase Mu 5 GSTM5 0.001
903 Glutathione S-transferase A5 GSTA5 0.001
4042 Glutathione transferase omega-2 GSTO2 0.001
4033 S-formylglutathione hydrolase ESD 0.001
4038 Glutathione peroxidase 4 GPX4 0.001
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.001
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
3319 Hydroxyacylglutathione hydrolase HAGH 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
898 Glutathione S-transferase A3 GSTA3 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
897 Glutathione S-transferase kappa 1 GSTK1 0.0009
909 Maleylacetoacetate isomerase GSTZ1 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
899 Glutathione S-transferase Mu 3 GSTM3 0.0008
905 Glutathione transferase omega-1 GSTO1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
2165 Glutathione S-transferase Mu 2 GSTM2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
207 Glutathione synthetase GSS 0.0008
5269 Glutathione synthetase gshB 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0007
2298 Cytochrome P450-cam camC 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
901 Glutathione S-transferase Mu 4 GSTM4 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
1039 Histone deacetylase 9 HDAC9 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
125 DNA polymerase beta POLB 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
714 Glutathione reductase, mitochondrial GSR 0.0006
6677 Myelin P2 protein PMP2 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0006
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑