DT-Web

DB01375 - Dihydroxyaluminium


Identification
Name Dihydroxyaluminium
Accession Number DB01375
Type small molecule
Description Aluminium monostearate is an organic compound which is a salt of stearic acid and aluminium. It has the molecular formula Al(OH)2C18H35O2. It is also referred to as dihydroxyaluminium or dihydroxy(stearato)aluminium. It is used to form gels in the packaging of pharmaceuticals, and in the preparation of colors for cosmetics. It is usually safe in commercial products, but aluminium may accumulate in the body.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 137.0708
Groups approved
Monoisotopic Weight 137.02687119
Pharmacology
Indication Not Available
Mechanism of action Aluminum hydroxide is one component of the antacids recommended in the treatment of stomach ulcers and gastritis. Antacids perform a neutralization reaction, ie. they buffer gastric acid, raising the pH to reduce acidity in the stomach. When gastric hydrochloric acid reaches the nerves in the gasitrointestinal mucosa, they signal pain to the central nervous system. This happens when these nerves are exposed, as in peptic ulcers. The gastric acid may also reach ulcers in the esophagus or the duodenum. Other mechanisms may contribute, such as the effect of aluminum ions inhibiting smooth muscle cell contraction and delaying gastric emptying. Aluminum is known to bind troponin C (a muscle protein) and to interfere with voltage-dependent calcium transport. Aluminum also binds to and inhibits the activity of mitochondrial voltage gated channels (VDAC).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir The antiacid decreases the absorption of amprenavir
Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
Chloroquine The antiacid decreases the absorption of chloroquine
Ciprofloxacin Formation of non-absorbable complexes
Clindamycin The aluminium salt decreases the absorption of lincosamides
Clodronate Formation of non-absorbable complexes
Tetracycline Formation of non-absorbable complexes
Food Interactions Not Available

Targets


Troponin C, slow skeletal and cardiac muscles
Name Troponin C, slow skeletal and cardiac muscles
Gene Name TNNC1
Pharmacological action unknown
Actions stimulator
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.0303
Voltage-dependent anion-selective channel protein 1
Name Voltage-dependent anion-selective channel protein 1
Gene Name VDAC1
Pharmacological action unknown
Actions inhibitor
References
  • Zhang DW, Colombini M: Inhibition by aluminum hydroxide of the voltage-dependent closure of the mitochondrial channel, VDAC. Biochim Biophys Acta. 1989 Apr 25;991(1):68-78. - Pubmed
  • Zhang DW, Colombini M: Group IIIA-metal hydroxides indirectly neutralize the voltage sensor of the voltage-dependent mitochondrial channel, VDAC, by interacting with a dynamic binding site. Biochim Biophys Acta. 1990 Jun 27;1025(2):127-34. - Pubmed
DTHybrid score 1.4492
Voltage-dependent anion-selective channel protein 2
Name Voltage-dependent anion-selective channel protein 2
Gene Name VDAC2
Pharmacological action unknown
Actions inhibitor
References
  • Zhang DW, Colombini M: Inhibition by aluminum hydroxide of the voltage-dependent closure of the mitochondrial channel, VDAC. Biochim Biophys Acta. 1989 Apr 25;991(1):68-78. - Pubmed
  • Zhang DW, Colombini M: Group IIIA-metal hydroxides indirectly neutralize the voltage sensor of the voltage-dependent mitochondrial channel, VDAC, by interacting with a dynamic binding site. Biochim Biophys Acta. 1990 Jun 27;1025(2):127-34. - Pubmed
DTHybrid score 1.4562
Voltage-dependent anion-selective channel protein 3
Name Voltage-dependent anion-selective channel protein 3
Gene Name VDAC3
Pharmacological action unknown
Actions inhibitor
References
  • Zhang DW, Colombini M: Inhibition by aluminum hydroxide of the voltage-dependent closure of the mitochondrial channel, VDAC. Biochim Biophys Acta. 1989 Apr 25;991(1):68-78. - Pubmed
  • Zhang DW, Colombini M: Group IIIA-metal hydroxides indirectly neutralize the voltage sensor of the voltage-dependent mitochondrial channel, VDAC, by interacting with a dynamic binding site. Biochim Biophys Acta. 1990 Jun 27;1025(2):127-34. - Pubmed
DTHybrid score 1.4468

Predictions


Id Partner name Gene Name Score
465 Calmodulin CALM1 0.0896
722 Troponin I, cardiac muscle TNNI3 0.0831
1108 Calpastatin CAST 0.0403
1089 Cartilage oligomeric matrix protein COMP 0.0403
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0403
6048 Troponin C, skeletal muscle TNNC2 0.0396
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0376
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0351
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0262
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.025
6859 Protein S100-A4 S100A4 0.0233
2132 Protein S100-B S100B 0.0232
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0232
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0223
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0203
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0181
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.018
1588 Multidrug resistance protein 1 ABCB1 0.0174
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0152
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0142
3947 Xanthine dehydrogenase/oxidase XDH 0.012
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0118
4119 Cytochrome P450 2D6 CYP2D6 0.0101
831 D(2) dopamine receptor DRD2 0.0097
556 Alpha-1A adrenergic receptor ADRA1A 0.0094
4200 Cytochrome P450 1A2 CYP1A2 0.0075
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0069
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0069
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0068
737 Mineralocorticoid receptor NR3C2 0.0068
6107 Cytochrome P450 3A7 CYP3A7 0.0042
4118 Cytochrome P450 3A5 CYP3A5 0.004
4924 Cytochrome P450 2C8 CYP2C8 0.004
4757 Cytochrome P450 2C9 CYP2C9 0.0036
4512 Cytochrome P450 3A4 CYP3A4 0.0032
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