DT-Web

DB01558 - Bromazepam


Identification
Name Bromazepam
Accession Number DB01558
Type small molecule
Description One of the benzodiazepines that is used in the treatment of anxiety disorders. [PubChem] It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepines.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 316.153
Groups illicit
Monoisotopic Weight 315.000724604
Pharmacology
Indication For the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and opiate-withdrawal.
Mechanism of action Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced.
Absorption Bioavailability is 84% following oral administration. The time to peak plasma level is 1 - 4 hours. Bromazepam is generally well absorbed after oral administration.
Protein binding 70%
Biotransformation Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes). One of the main metabolites is 3-hydroxybromazepam. It is pharmacologically active and the half life is similar to that of the parent compound.
Route of elimination Urine (69%), as metabolites
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline Aminophylline may decrease the therapeutic effect of bromazepam. Monitor for changes in the therapeutic effects of bromazepam if aminophylline is initiated, discontinued or dose changed.
Atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if atazanavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Cimetidine Co-administration with cimetidine will cause a reduction in bromazepam clearance and increases half-life.
Clarithromycin Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if clarithromycin is initiated, discontinued or dose changed. Dosage adjustments may be required.
Clozapine Bromazepam may increase the adverse effects of clozapine. Consider alternate therapy or a reduction in the bromazepam dose. Monitor for respiratory depression and hypotension if concomitant therapy is initiated.
Conivaptan Conivaptan, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if conivaptan is initiated, discontinued or dose changed. Dosage adjustments may be required.
Darunavir Darunavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if darunavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Delavirdine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if delavirdine is initiated, discontinued or dose changed. Dosage adjustments may be required.
Diltiazem Diltiazem may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or a reductin in the bromazepam dose. Monitor for changes in the therapeutic and adverse effects of bromazepam if diltiazem is initiated, discontinued or dose changed.
Dyphylline Dyphylline may decrease the therapeutic effect of bromazepam. Monitor for changes in the therapeutic effects of bromazepam if dyphylline is initiated, discontinued or dose changed.
Erythromycin Erythromcyin may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if erythromycin is initiated, discontinued or dose changed. Dosage adjustments may be required.
Fluconazole Fluconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if fluconazole is initiated, discontinued or dose changed.
Fosamprenavir Fosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if fosamprenavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Imatinib Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if imatinib is initiated, discontinued or dose changed. Dosage adjustments may be required.
Indinavir Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if indinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Isoniazid Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if isoniazid is initiated, discontinued or dose changed. Dosage adjustments may be required.
Itraconazole Itraconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if itraconazole is initiated, discontinued or dose changed.
Ketoconazole Ketoconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if ketoconazole is initiated, discontinued or dose changed.
Lopinavir Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if lopinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Methotrimeprazine Concomitant therapy may result in additive CNS depressant effects. The dosage of bromazepam should be decreased by 50% prior to initiating concomitant therapy. Monitor for increased CNS depression.
Nefazodone Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if nefazodone is initiated, discontinued or dose changed. Dosage adjustments may be required.
Nelfinavir Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if nelfinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Nicardipine Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if nicardipine is initiated, discontinued or dose changed. Dosage adjustments may be required.
Posaconazole Posaconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if posaconazole is initiated, discontinued or dose changed.
Propranolol Co-administration with propranolol will cause a reduction in bromazepam clearance and increases half-life.
Quinidine Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if quinidine is initiated, discontinued or dose changed. Dosage adjustments may be required.
Rifabutin Rifabutin may decrease the serum concentration of bromazepam by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if rifabutin is initiated, discontinued or dose changed.
Rifampin Rifampin may decrease the serum concentration of bromazepam by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if rifampin is initiated, discontinued or dose changed.
Rifapentine Rifapentine may decrease the serum concentration of bromazepam by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if rifapentine is initiated, discontinued or dose changed.
Ritonavir Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if ritonavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Saquinavir Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if saquinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if telithromycin is initiated, discontinued or dose changed. Dosage adjustments may be required.
Theophylline Theophylline may decrease the therapeutic effect of bromazepam. Monitor for changes in the therapeutic effects of bromazepam if theophylline is initiated, discontinued or dose changed.
Tipranavir Tipranavir may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if tipranavir is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Bromazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Verapamil Verapamil may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or a reductin in the bromazepam dose. Monitor for changes in the therapeutic and adverse effects of bromazepam if verapamil is initiated, discontinued or dose changed.
Voriconazole Voriconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.2499
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.1856
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.1827
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 0.8483
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.2074
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 0.817
Gamma-aminobutyric-acid receptor subunit beta-1
Name Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name GABRB1
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0578
Gamma-aminobutyric-acid receptor subunit beta-2
Name Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name GABRB2
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0467
Gamma-aminobutyric-acid receptor subunit beta-3
Name Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name GABRB3
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0626
Gamma-aminobutyric acid receptor subunit gamma-1
Name Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name GABRG1
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0455
Gamma-aminobutyric acid receptor subunit gamma-2
Name Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name GABRG2
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0785
Gamma-aminobutyric acid receptor subunit gamma-3
Name Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name GABRG3
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0277
Gamma-aminobutyric acid receptor subunit delta
Name Gamma-aminobutyric acid receptor subunit delta
Gene Name GABRD
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0341
Gamma-aminobutyric acid receptor subunit epsilon
Name Gamma-aminobutyric acid receptor subunit epsilon
Gene Name GABRE
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0322
Gamma-aminobutyric acid receptor subunit pi
Name Gamma-aminobutyric acid receptor subunit pi
Gene Name GABRP
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0184
Gamma-aminobutyric-acid receptor subunit rho-1
Name Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name GABRR1
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.024
Gamma-aminobutyric acid receptor subunit rho-2
Name Gamma-aminobutyric acid receptor subunit rho-2
Gene Name GABRR2
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0293
Gamma-aminobutyric acid receptor subunit rho-3
Name Gamma-aminobutyric acid receptor subunit rho-3
Gene Name GABRR3
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0264
Gamma-aminobutyric acid receptor subunit theta
Name Gamma-aminobutyric acid receptor subunit theta
Gene Name GABRQ
Pharmacological action yes
Actions potentiator
References
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 0.6756

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8424
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.416
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5035
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4459

Predictions


Id Partner name Gene Name Score
811 Translocator protein TSPO 0.3935
4757 Cytochrome P450 2C9 CYP2C9 0.3801
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.2949
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.2947
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.2868
6030 Cytochrome P450 2B6 CYP2B6 0.2618
1588 Multidrug resistance protein 1 ABCB1 0.26
4119 Cytochrome P450 2D6 CYP2D6 0.2539
921 Glutamate receptor 2 GRIA2 0.2533
4118 Cytochrome P450 3A5 CYP3A5 0.2362
4924 Cytochrome P450 2C8 CYP2C8 0.2279
6107 Cytochrome P450 3A7 CYP3A7 0.2066
5718 Cytochrome P450 2A6 CYP2A6 0.1353
587 Serum albumin ALB 0.1346
6106 Cytochrome P450 2C18 CYP2C18 0.1334
6024 Cytochrome P450 1A1 CYP1A1 0.1107
20 Prostaglandin G/H synthase 1 PTGS1 0.0976
6102 Arylamine N-acetyltransferase 2 NAT2 0.056
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0552
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0547
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.053
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0529
6031 Cytochrome P450 3A43 CYP3A43 0.0525
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0518
482 Glycine receptor subunit alpha-1 GLRA1 0.0517
6144 Solute carrier family 22 member 2 SLC22A2 0.0507
6145 Solute carrier family 22 member 1 SLC22A1 0.0484
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0446
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0432
3811 Cytochrome P450 19A1 CYP19A1 0.0416
492 Histamine H1 receptor HRH1 0.0403
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0367
824 Sodium-dependent serotonin transporter SLC6A4 0.0363
1898 Cytochrome P450 1B1 CYP1B1 0.0357
461 Glycine receptor subunit alpha-3 GLRA3 0.0352
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.035
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0344
862 Multidrug resistance-associated protein 1 ABCC1 0.034
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0336
556 Alpha-1A adrenergic receptor ADRA1A 0.0333
502 5-hydroxytryptamine 2A receptor HTR2A 0.0321
820 Glycine receptor subunit alpha-2 GLRA2 0.0311
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0309
318 Alpha-2A adrenergic receptor ADRA2A 0.03
831 D(2) dopamine receptor DRD2 0.0289
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0286
1729 Solute carrier family 22 member 6 SLC22A6 0.0285
23 D(1A) dopamine receptor DRD1 0.0279
290 Prostaglandin G/H synthase 2 PTGS2 0.0278
260 Cytochrome P450 51 ERG11 0.0271
761 Cytochrome P450 51 ERG11 0.0271
3163 Cytochrome P450 51 cyp51 0.0271
3937 Fatty-acid amide hydrolase FAAH 0.0265
36 Insulin receptor INSR 0.0258
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0249
468 Cytochrome P450 4A11 CYP4A11 0.0247
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0242
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0242
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0238
3941 Amine oxidase [flavin-containing] A MAOA 0.0228
776 Bile salt export pump ABCB11 0.0222
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0217
705 Glutamate receptor 1 GRIA1 0.0214
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0209
320 5-hydroxytryptamine 1A receptor HTR1A 0.0207
136 Estrogen receptor ESR1 0.0207
537 ATP synthase delta chain, mitochondrial ATP5D 0.0207
590 5-hydroxytryptamine 2C receptor HTR2C 0.0203
3426 Glutamine synthetase glnA 0.0201
3987 Glutamine synthetase GLUL 0.0201
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0201
871 Glucocorticoid receptor NR3C1 0.0201
2981 Phospholipase A2, membrane associated PLA2G2A 0.0199
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0195
632 Alpha-1B adrenergic receptor ADRA1B 0.0191
731 HIV-1 protease HIV-1 protease 0.0186
817 DNA topoisomerase 2-alpha TOP2A 0.0185
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0184
341 5-hydroxytryptamine 3 receptor HTR3A 0.0183
885 5-hydroxytryptamine 1B receptor HTR1B 0.0183
713 Sodium-dependent dopamine transporter SLC6A3 0.018
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0172
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0167
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0165
3939 Amine oxidase [flavin-containing] B MAOB 0.0165
766 Beta-2 adrenergic receptor ADRB2 0.0165
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0163
118 Organic cation/carnitine transporter 2 SLC22A5 0.0162
629 Alpha-2B adrenergic receptor ADRA2B 0.0162
172 Potassium channel subfamily K member 1 KCNK1 0.0158
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0158
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0158
465 Calmodulin CALM1 0.0157
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0154
725 5-hydroxytryptamine 1D receptor HTR1D 0.0153
789 Alpha-1D adrenergic receptor ADRA1D 0.0152
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.015
16 Adenosine A1 receptor ADORA1 0.0148
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
193 Beta-1 adrenergic receptor ADRB1 0.0145
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
638 D(3) dopamine receptor DRD3 0.0141
6142 Solute carrier family 22 member 8 SLC22A8 0.014
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0134
777 Tumor necrosis factor TNF 0.0134
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0133
2164 Multidrug resistance-associated protein 4 ABCC4 0.0133
62 Glycine receptor subunit beta GLRB 0.0132
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0131
6143 Solute carrier family 22 member 7 SLC22A7 0.0131
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0127
489 Monocarboxylate transporter 2 SLC16A7 0.0126
3923 Cholinesterase BCHE 0.0125
847 Mu-type opioid receptor OPRM1 0.0123
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0122
738 Monocarboxylate transporter 1 SLC16A1 0.012
6147 Solute carrier family 22 member 3 SLC22A3 0.0118
500 Monocarboxylate transporter 4 SLC16A3 0.0118
833 Organic cation/carnitine transporter 1 SLC22A4 0.0117
378 Alpha-2C adrenergic receptor ADRA2C 0.0117
1178 Adenosine A2a receptor ADORA2A 0.0113
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0112
6220 Aryl hydrocarbon receptor AHR 0.0112
122 P2Y purinoceptor 12 P2RY12 0.0107
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0106
613 Atrial natriuretic peptide receptor A NPR1 0.0106
592 Carbonic anhydrase 4 CA4 0.0105
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0104
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0104
432 D(4) dopamine receptor DRD4 0.0103
467 Delta-type opioid receptor OPRD1 0.0103
818 50S ribosomal protein L10 rplJ 0.0102
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0101
6020 Aldehyde oxidase AOX1 0.01
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0098
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
571 Melatonin receptor type 1A MTNR1A 0.0096
6014 Cytochrome P450 2A13 CYP2A13 0.0096
362 Melatonin receptor type 1B MTNR1B 0.0096
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0096
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0093
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0092
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0092
696 Kappa-type opioid receptor OPRK1 0.0092
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0092
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0092
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0088
3947 Xanthine dehydrogenase/oxidase XDH 0.0088
146 Androgen receptor AR 0.0087
1757 Myeloperoxidase MPO 0.0086
4122 Histone deacetylase 2 HDAC2 0.0085
436 5-hydroxytryptamine 2B receptor HTR2B 0.0084
1010 Cytochrome P450 51A1 CYP51A1 0.0084
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0083
124 Histamine H2 receptor HRH2 0.0083
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0082
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0081
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
6148 Multidrug resistance-associated protein 7 ABCC10 0.008
614 Progesterone receptor PGR 0.0079
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0078
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0078
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0078
251 Alcohol dehydrogenase 1A ADH1A 0.0077
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0077
357 Carbonic anhydrase 2 CA2 0.0077
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0077
6182 Cytochrome P450 2J2 CYP2J2 0.0077
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0076
444 Alcohol dehydrogenase 1B ADH1B 0.0075
4604 Liver carboxylesterase 1 CES1 0.0075
716 5-hydroxytryptamine 7 receptor HTR7 0.0075
94 5-hydroxytryptamine 4 receptor HTR4 0.0073
1024 Solute carrier family 22 member 11 SLC22A11 0.0071
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
238 Peroxisome proliferator-activated receptor gamma PPARG 0.007
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
373 Transthyretin TTR 0.0069
161 Tubulin beta chain TUBB 0.0068
312 Tubulin beta chain TUB2 0.0068
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0066
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0065
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0065
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0065
163 D(1B) dopamine receptor DRD5 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0064
869 Estrogen receptor beta ESR2 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0062
26 Vascular endothelial growth factor receptor 3 FLT4 0.0062
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.006
295 Carbonic anhydrase 1 CA1 0.0059
32 Vascular endothelial growth factor receptor 1 FLT1 0.0059
756 Sex hormone-binding globulin SHBG 0.0059
70 Type-1 angiotensin II receptor AGTR1 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
517 Alcohol dehydrogenase 1C ADH1C 0.0059
844 Epidermal growth factor receptor EGFR 0.0059
6136 Multidrug resistance-associated protein 5 ABCC5 0.0059
6137 Multidrug resistance-associated protein 6 ABCC6 0.0059
284 DNA-directed RNA polymerase beta chain rpoB 0.0059
5773 DNA-directed RNA polymerase beta chain rpoB 0.0059
407 Vascular endothelial growth factor receptor 2 KDR 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
1656 CYP2B protein CYP2B 0.0057
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0055
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0055
1256 5-hydroxytryptamine 6 receptor HTR6 0.0055
6141 Sodium/bile acid cotransporter SLC10A1 0.0055
891 Dihydropteroate synthase folP 0.0054
5359 Dihydropteroate synthase folP 0.0054
7175 Dihydropteroate synthase sulI 0.0054
29 Tubulin beta-1 chain TUBB1 0.0054
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0054
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
504 Mast/stem cell growth factor receptor KIT 0.0053
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0052
814 Ryanodine receptor 1 RYR1 0.0052
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0052
49 Endothelin B receptor EDNRB 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
380 Cytochrome P450 17A1 CYP17A1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0052
518 Peroxidase/catalase T katG 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
904 Glutathione S-transferase P GSTP1 0.0051
6432 Transporter snf 0.0051
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.005
6126 Carbonic anhydrase 7 CA7 0.005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0049
474 Acetylcholinesterase ACHE 0.0049
228 Beta platelet-derived growth factor receptor PDGFRB 0.0049
153 Dopamine beta-hydroxylase DBH 0.0049
563 Thyroid peroxidase TPO 0.0048
511 5-hydroxytryptamine 1F receptor HTR1F 0.0048
427 Substance-P receptor TACR1 0.0048
68 Cannabinoid receptor 1 CNR1 0.0048
183 Vascular endothelial growth factor A VEGFA 0.0048
823 Fibroblast growth factor receptor 2 FGFR2 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
1483 Membrane copper amine oxidase AOC3 0.0046
1253 Interferon gamma IFNG 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0046
173 Toll-like receptor 7 TLR7 0.0046
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
365 Dihydrofolate reductase DHFR 0.0046
2381 Dihydrofolate reductase DFR1 0.0046
2833 Dihydrofolate reductase Not Available 0.0046
2931 Dihydrofolate reductase folA 0.0046
3544 Dihydrofolate reductase folA 0.0046
3682 Dihydrofolate reductase folA 0.0046
6642 Dihydrofolate reductase folA 0.0046
6756 Dihydrofolate reductase dfrA 0.0046
6043 Putative G-protein coupled receptor 44 GPR44 0.0045
273 Apoptosis regulator Bcl-2 BCL2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
3810 Catechol O-methyltransferase COMT 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0043
952 Dipeptidyl peptidase 4 DPP4 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
856 Vitamin D3 receptor VDR 0.0042
4120 NADPH--cytochrome P450 reductase POR 0.0042
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0041
528 5-hydroxytryptamine 1E receptor HTR1E 0.0041
1517 Beta-3 adrenergic receptor ADRB3 0.004
4311 tRNA TRDMT1 0.004
4325 tRNA trmD 0.004
4328 tRNA trmD 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
275 Arachidonate 5-lipoxygenase ALOX5 0.004
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.004
1129 C-C chemokine receptor type 5 CCR5 0.0039
3932 Glutathione S-transferase A2 GSTA2 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6044 Serum paraoxonase/lactonase 3 PON3 0.0038
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0038
85 Growth hormone receptor GHR 0.0038
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0037
1192 Sulfotransferase 1A1 SULT1A1 0.0037
634 Squalene monooxygenase SQLE 0.0036
7196 Squalene monooxygenase ERG1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
3404 Exotoxin A eta 0.0036
239 Coagulation factor X F10 0.0035
65 Matrix metalloproteinase-9 Not Available 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0034
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0034
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0034
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0034
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
1618 High affinity nerve growth factor receptor NTRK1 0.0034
6138 Multidrug resistance protein 3 ABCB4 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
976 Platelet glycoprotein IX GP9 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6146 High affinity copper uptake protein 1 SLC31A1 0.0033
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0033
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0033
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0032
3957 Adenosine deaminase ADA 0.0032
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
3601 Dihydropteroate synthase 1 folP1 0.0031
3807 Dihydropteroate synthase 1 folP1 0.0031
3808 Dihydropteroate synthase 2 folP2 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0031
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
737 Mineralocorticoid receptor NR3C2 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
2290 ADP-ribosyl cyclase 2 BST1 0.0028
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
33 Cystine/glutamate transporter SLC7A11 0.0028
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0028
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0027
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0027
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0027
1268 Neuropeptide S receptor NPSR1 0.0027
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0027
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0027
2298 Cytochrome P450-cam camC 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
319 Opioid receptor, sigma 1 OPRS1 0.0027
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1629 Transcription factor AP-1 JUN 0.0026
1648 Elastin ELN 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0025
5880 Thrombopoietin receptor MPL 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0024
6073 Potassium channel subfamily K member 9 KCNK9 0.0024
6072 Potassium channel subfamily K member 3 KCNK3 0.0024
581 Cytochrome P450 2R1 CYP2R1 0.0024
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0023
3809 Estrogen-related receptor gamma ESRRG 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
358 Cystathionine beta-synthase CBS 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
174 Sigma 1-type opioid receptor SIGMAR1 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0022
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0022
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
7 Nitric oxide synthase, inducible NOS2 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0022
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
780 Retinoic acid receptor RXR-gamma RXRG 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
1360 Sphingomyelin phosphodiesterase SMPD1 0.0021
268 Adenosine A2b receptor ADORA2B 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
896 Glutathione S-transferase Mu 1 GSTM1 0.002
4103 Proteasome subunit beta type 2 PSMB2 0.002
4102 Proteasome subunit beta type 5 PSMB5 0.002
4101 Proteasome subunit beta type 1 PSMB1 0.002
1820 Beta-nerve growth factor NGF 0.002
88 Retinoic acid receptor RXR-beta RXRB 0.002
106 Cannabinoid receptor 2 CNR2 0.002
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
6174 50S ribosomal protein L32 rpmF 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
54 Prothrombin F2 0.0018
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0018
165 FL cytokine receptor FLT3 0.0018
469 Annexin A1 ANXA1 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
164 Histamine H4 receptor HRH4 0.0018
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
2207 Rhodopsin RHO 0.0018
683 Potassium transporter GK0582 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
84 Nuclear receptor 0B1 NR0B1 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0017
3830 Calreticulin CALR 0.0017
1275 Estrogen sulfotransferase SULT1E1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0017
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
6085 Fatty acid-binding protein, intestinal FABP2 0.0017
936 Ephrin type-A receptor 2 EPHA2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
751 Potassium channel subfamily K member 6 KCNK6 0.0016
1243 Cathepsin D CTSD 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
5787 Angiopoietin-1 receptor TEK 0.0016
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0015
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
3856 Fibroblast growth factor receptor 3 FGFR3 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
1864 RET proto-oncogene RET 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
1541 Metalloproteinase mmp20 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
798 Osteocalcin BGLAP 0.0014
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0014
6859 Protein S100-A4 S100A4 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
1992 Vitamin D-binding protein GC 0.0013
5934 Cytochrome P450 26A1 CYP26A1 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0013
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0013
369 Coagulation factor VII F7 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1630 Integrin beta-2 ITGB2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
162 Retinoic acid receptor gamma-1 RARG 0.001
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
572 Integrin alpha-L ITGAL 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0009
3221 Cytochrome c4 cc4 0.0009
5798 Mitogen-activated protein kinase 11 MAPK11 0.0009
4773 Deoxycytidine kinase DCK 0.0009
2320 Thymidine kinase, cytosolic TK1 0.0009
267 Plasminogen activator inhibitor 1 SERPINE1 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
229 Retinoic acid receptor beta RARB 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6218 Pannexin-1 PANX1 0.0008
6221 Steroid hormone receptor ERR1 ESRRA 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0007
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
2021 Thrombomodulin THBD 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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