DT-Web

DB01211 - Clarithromycin


Identification
Name Clarithromycin
Accession Number DB01211 (APRD00181)
Type small molecule
Description Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 747.9534
Groups approved
Monoisotopic Weight 747.476891299
Pharmacology
Indication An alternative medication for the treatment of acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of ?-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for Mycobacterium avium complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection).
Mechanism of action Clarithromycin is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.
Absorption Clarithromycin is well-absorbed, acid stable and may be taken with food.
Protein binding ~ 70% protein bound
Biotransformation Hepatic - predominantly metabolized by CYP3A4 resulting in numerous drug interactions.
Route of elimination After a 250 mg tablet every 12 hours, approximately 20% of the dose is excreted in the urine as clarithromycin, while after a 500 mg tablet every 12 hours, the urinary excretion of clarithromycin is somewhat greater, approximately 30%.
Toxicity Symptoms of toxicity include diarrhea, nausea, abnormal taste, dyspepsia, and abdominal discomfort. Transient hearing loss with high doses has been observed. Pseudomembraneous colitis has been reported with clarithromycin use. Allergic reactions ranging from urticaria and mild skin eruptions to rare cases of anaphylaxis and Stevens-Johnson syndrome have also occurred. Rare cases of severe hepatic dysfunctions also have been reported. Hepatic failure is usually reversible, but fatalities have been reported. Clarithromycin may also cause tooth decolouration which may be removed by dental cleaning. Fetal abnormalities, such as cardiovascular defects, cleft palate and fetal growth retardation, have been observed in animals. Clarithromycin may cause QT prolongation.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Abiraterone Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol The macrolide, clarithromycin, may increase the anticoagulant effect of acenocoumarol.
Alprazolam The macrolide, clarithromycin, may increase the effect of the benzodiazepine, alprazolam.
Alvimopan Decreases levels by P-glycoprotein (MDR-1) efflux transporter. Can significantly increase systemic exposure to P-glycoprotein substrates.
Aminophylline Clarithromycin may increase the effect amd toxicity of aminophylline.
Amiodarone Increased risk of cardiotoxicity and arrhythmias
Anisindione The macrolide, clarithromycin, may increase the anticoagulant effect of anisindione.
Aprepitant The CYP3A4 inhibitor, clarithromycin, may increase the effect and toxicity of aprepitant.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atazanavir Atazanavir may increase serum level of clarithromycin.
Atorvastatin The macrolide, clarithromycin, may increase the toxicity of the statin, atorvastatin.
Bretylium Increased risk of cardiotoxicity and arrhythmias
Bromazepam Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if clarithromycin is initiated, discontinued or dose changed. Dosage adjustments may be required.
Buspirone Clarithromycin may increase the effect and toxicity of buspirone.
Cabazitaxel Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Carbamazepine Clarithromycin may decrease the metabolism of carbamazepine. Monitor for changes in the therapeutic or adverse effects of carbamazepine if clarithromycin is initiated, discontinued or dose changed.
Cerivastatin The macrolide, clarithromycin, may increase the toxicity of the statin, cerivastatin.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Citalopram Possible serotoninergic syndrome with this combination
Colchicine Severe colchicine toxicity can occur
Cyclosporine The macrolide, clarithromycin, may increase the effect of cyclosporine.
Dabrafenib Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Dantrolene Clarithromycin may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if clarithromycin is initiated, discontinued or dose changed.
Darifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Darunavir Increased levels of clarithromycin
Diazepam The macrolide, clarithromycin, may increase the effect of the benzodiazepine, diazepam.
Dicumarol The macrolide, clarithromycin, may increase the anticoagulant effect of dicumarol.
Digoxin The macrolide, clarithromycin, may increase the effect of digoxin in 10% of patients.
Dihydroergotamine Risk of ergotism and severe ischemia with this association
Disopyramide Increased risk of cardiotoxicity and arrhythmias
Dofetilide Increased risk of cardiotoxicity and arrhythmias
Dronedarone Clarithromycin is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Dyphylline Increases the effect and toxicity of theophylline
Efavirenz Efavirenz decreases levels of clarithromycin
Eletriptan The macrolide, clarithromycin, may increase the effect and toxicity of eletriptan.
Eplerenone The macrolide, clarithromycin, may increase the effect and toxicity of eplerenone.
Ergotamine Risk of ergotism and severe ischemia with this association
Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Etravirine Clarithromycin (and other macrolide antibiotics), when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to use alternative antibiotic agents if available. If concurrent therapy cannot be avoided, monitor for reduced effectiveness of clarithromycin.
Everolimus The macrolide, clarithromycin, may increase the serum concentration and toxicity of everolimus.
Fluoxetine Possible serotoninergic syndrome with this combination
Fosphenytoin Clarithromycin may increase the therapeutic and adverse effects of fosphenytoin.
Gefitinib This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Iloperidone Clarithromycin is a strong CYP3A4 inhibitor that increases serum concentration of iloperidone. Reduce dose of iloperidone by 50%
Imatinib The macrolide, clarithromycin, may increase the serum concentration of imatinib.
Indinavir Indinavir may decrease the effectiveness of clarithromycin by decreasing the formatin of the active metabolite, 14-hydroxy-clarithromycin. Clarithromycin may increase the serum concentration of indinavir. Indinavir may increase the serum concentration of clarithromycin. Consider alternate therapy or monitor the efficacy and adverse effects of both agents more closely during concomitant therapy.
Itraconazole The macrolide, clarithromycin, may increase the effect and toxicity of itraconazole.
Ivacaftor Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Lovastatin The macrolide, clarithromycin, may increase the toxicity of the statin, lovastatin.
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Methylprednisolone The macrolide, clarithromycin, may increase the effect of corticosteroid, methylprednisolone.
Methysergide Risk of ergotism and severe ischemia with this association
Midazolam The macrolide, clarithromycin, may increase the effect of the benzodiazepine, midazolam.
Oxtriphylline Clarithromycin may increase the effect and toxicity of oxtriphylline.
Pazopanib Clarithromycin is a strong inhibitor of CYP3A4 thus increasing exposure of pazopanib.
Phenytoin Clarithromycin may increase the therapeutic and adverse effects of phenytoin.
Pimozide Increased risk of cardiotoxicity and arrhythmias
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Quetiapine The macrolide, clarithromycin, may increase the effect and toxicity of quetiapine.
Quinidine Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Quinupristin This combination presents an increased risk of toxicity
Ranolazine Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum level of ranolazine. Concomitant therapy is contraindicated.
Regorafenib Strong CYP3A4 inhibitors may increase levels of regorafenib.
Repaglinide Clarithromycin may increase the effect of repaglinide.
Rifabutin The rifamycin, rifabutin, may decrease the effect of the macrolide, clarithromycin.
Rifampin The rifamycin, rifampin, may decrease the effect of the macrolide, clarithromycin.
Saxagliptin Clarithromycin is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Sertraline Possible serotoninergic syndrome with this combination
Sildenafil Increases the effect and toxicity of sildenafil
Simvastatin The macrolide, clarithromycin, may increase the toxicity of the statin, simvastatin.
Sirolimus The macrolide, clarithromycin, may increase the serum concentration of sirolimus.
Solifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Sotalol Increased risk of cardiotoxicity and arrhythmias
Sunitinib Possible increase in sunitinib levels
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. The macrolide antibiotic, Clarithromycin, may also increase the blood concentration of Tacrolimus.
Tadalafil Clarithromycin may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Clarithromycin may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin Clarithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clarithromycin is initiated, discontinued, or dose changed.
Telithromycin Co-administration may result in altered plasma concentrations of Clarithromycin and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents.
Temsirolimus Clarithromycin may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Clarithromycin, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Clarithromycin is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline Clarithromycin may increase the therapeutic and adverse effects of theophylline.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tiagabine The strong CYP3A4 inhibitor, Clarithromycin, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Clarithromycin is initiated, discontinued or dose changed.
Tipranavir The concentrations of Tipranavir and Clarithromycin increase during concomitant therapy. Dose adjustments are required for patients with renal impairment.
Tolterodine Clarithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan Clarithromycin is a strong inhibitor of CYP3A4 and will increase serum concentrations of tolvaptan.
Topotecan The p-glycoprotein inhibitor, Clarithromycin, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Clarithromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Clarithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Clarithromycin is initiated, discontinued or dose changed.
Triazolam The macrolide, clarithromycin, may increase the effect of the benzodiazepine, triazolam.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Clarithromycin, a strong CYP3A4 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Concomitant therapy should be used with caution.
Valproic Acid The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Clarithromycin is initiated, discontinued or dose changed.
Vardenafil Clarithromycin, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Vemurafenib Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine Clarithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Clarithromycin is initiated, discontinued, or dose changed.
Verapamil Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Clarithromycin is initiated, discontinued or dose changed.
Vilazodone CYP3A4 Inhibitors (Strong) may increase the serum concentration of Vilazodone. imit maximum adult vilazodone dose to 20 mg/day in patients receiving strong CYP3A4 inhibitors.
Vinblastine Clarithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Clarithromycin is initiated, discontinued or dose changed.
Vincristine Clarithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Clarithromycin is initiated, discontinued or dose changed.
Vinorelbine Clarithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinorelbine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Clarithromycin is initiated, discontinued or dose changed.
Vismodegib P-glycoprotein inhibitors may increase the chance of adverse drug reactions.
Voriconazole Additive QTc prolongation may occur. Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of clarithromycin by decreasing its metabolism. Clarithromycin may increase the serum concentration of voriconazole by decreasing its metabolism. Consider alternate therapy or monitor for QTc prolongation and changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin The macrolide, clarithromycin, may increase the anticoagulant effect of warfarin.
Zidovudine Clarithromycin may decrease the serum concentration of zidovudine. Increased myelosuppression in mice has been observed. Consider staggering doses during concomitant therapy and closely monitor response to zidovudine therapy.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolpidem Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if clarithromycin is initiated, discontinued or dose changed.
Zonisamide Clarithromcyin, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if clarithromycin is initiated, discontinued or dose changed.
Zopiclone Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if clarithromycin is initiated, discontinued or dose changed.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Biaxin - take without regard to meals (however absorption appears to be improved when drug is taken with food).
  • Biaxin XL - take with a meal, taking it on an empty stomach is associated with total product exposure 30% inferior to that observed when administered with food.

Targets


50S ribosomal protein L10
Name 50S ribosomal protein L10
Gene Name rplJ
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Morimura T, Hashiba M, Kameda H, Takami M, Takahama H, Ohshige M, Sugawara F: Identification of macrolide antibiotic-binding Human_p8 protein. J Antibiot (Tokyo). 2008 May;61(5):291-6. - Pubmed
  • Champney WS, Burdine R: Macrolide antibiotic inhibition of translation and 50S ribosomal subunit assembly in methicillin-resistant Staphylococcus aureus cells. Microb Drug Resist. 1998 Fall;4(3):169-74. - Pubmed
  • Zuckerman JM, Qamar F, Bono BR: Macrolides, ketolides, and glycylcyclines: azithromycin, clarithromycin, telithromycin, tigecycline. Infect Dis Clin North Am. 2009 Dec;23(4):997-1026, ix-x. - Pubmed
  • Clarithromycin. Tuberculosis (Edinb). 2008 Mar;88(2):92-5. - Pubmed
  • Champney WS, Burdine R: Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureus. Antimicrob Agents Chemother. 1995 Sep;39(9):2141-4. - Pubmed
DTHybrid score 0.6988

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Zuckerman JM, Qamar F, Bono BR: Macrolides, ketolides, and glycylcyclines: azithromycin, clarithromycin, telithromycin, tigecycline. Infect Dis Clin North Am. 2009 Dec;23(4):997-1026, ix-x. - Pubmed
  • Clarithromycin. Tuberculosis (Edinb). 2008 Mar;88(2):92-5. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. - Pubmed
DTHybrid score 0.7411
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
DTHybrid score 0.4186
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
DTHybrid score 0.331
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3712
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4228

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Egashira K, Ohtani H, Itoh S, Koyabu N, Tsujimoto M, Murakami H, Sawada Y: Inhibitory effects of pomelo on the metabolism of tacrolimus and the activities of CYP3A4 and P-glycoprotein. Drug Metab Dispos. 2004 Aug;32(8):828-33. - Pubmed
  • Clarithromycin. Tuberculosis (Edinb). 2008 Mar;88(2):92-5. - Pubmed
  • Dey S, Gunda S, Mitra AK: Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption. J Pharmacol Exp Ther. 2004 Oct;311(1):246-55. Epub 2004 Jun 2. - Pubmed
DTHybrid score 0.4567
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T: Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. Epub 2005 Feb 11. - Pubmed
DTHybrid score 0.1669

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.2876
4119 Cytochrome P450 2D6 CYP2D6 0.2861
4924 Cytochrome P450 2C8 CYP2C8 0.2071
6030 Cytochrome P450 2B6 CYP2B6 0.171
6013 Cytochrome P450 2E1 CYP2E1 0.1268
6024 Cytochrome P450 1A1 CYP1A1 0.1164
4237 50S ribosomal protein L22 rplV 0.1071
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1031
587 Serum albumin ALB 0.0994
1729 Solute carrier family 22 member 6 SLC22A6 0.0955
6142 Solute carrier family 22 member 8 SLC22A8 0.0857
5718 Cytochrome P450 2A6 CYP2A6 0.083
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0769
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0765
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0679
862 Multidrug resistance-associated protein 1 ABCC1 0.0678
20 Prostaglandin G/H synthase 1 PTGS1 0.0646
1024 Solute carrier family 22 member 11 SLC22A11 0.0598
6145 Solute carrier family 22 member 1 SLC22A1 0.0578
6106 Cytochrome P450 2C18 CYP2C18 0.0539
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0534
492 Histamine H1 receptor HRH1 0.0533
6144 Solute carrier family 22 member 2 SLC22A2 0.0493
824 Sodium-dependent serotonin transporter SLC6A4 0.0485
3811 Cytochrome P450 19A1 CYP19A1 0.0459
1898 Cytochrome P450 1B1 CYP1B1 0.0444
831 D(2) dopamine receptor DRD2 0.0424
556 Alpha-1A adrenergic receptor ADRA1A 0.042
776 Bile salt export pump ABCB11 0.0419
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0415
502 5-hydroxytryptamine 2A receptor HTR2A 0.041
6031 Cytochrome P450 3A43 CYP3A43 0.0408
871 Glucocorticoid receptor NR3C1 0.0398
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0389
290 Prostaglandin G/H synthase 2 PTGS2 0.0387
847 Mu-type opioid receptor OPRM1 0.0376
320 5-hydroxytryptamine 1A receptor HTR1A 0.0364
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0356
2164 Multidrug resistance-associated protein 4 ABCC4 0.0347
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0345
318 Alpha-2A adrenergic receptor ADRA2A 0.0339
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0337
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0333
118 Organic cation/carnitine transporter 2 SLC22A5 0.033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0321
731 HIV-1 protease HIV-1 protease 0.0308
260 Cytochrome P450 51 ERG11 0.0307
761 Cytochrome P450 51 ERG11 0.0307
3163 Cytochrome P450 51 cyp51 0.0307
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0305
817 DNA topoisomerase 2-alpha TOP2A 0.03
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0295
23 D(1A) dopamine receptor DRD1 0.0294
632 Alpha-1B adrenergic receptor ADRA1B 0.0283
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0281
766 Beta-2 adrenergic receptor ADRB2 0.0278
136 Estrogen receptor ESR1 0.0276
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0276
467 Delta-type opioid receptor OPRD1 0.0271
590 5-hydroxytryptamine 2C receptor HTR2C 0.0266
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0262
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.026
36 Insulin receptor INSR 0.0258
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0256
193 Beta-1 adrenergic receptor ADRB1 0.0255
638 D(3) dopamine receptor DRD3 0.0251
885 5-hydroxytryptamine 1B receptor HTR1B 0.025
3941 Amine oxidase [flavin-containing] A MAOA 0.0249
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0249
713 Sodium-dependent dopamine transporter SLC6A3 0.0245
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0243
696 Kappa-type opioid receptor OPRK1 0.0242
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0239
6148 Multidrug resistance-associated protein 7 ABCC10 0.0239
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0237
477 DNA topoisomerase 4 subunit A parC 0.0236
886 DNA topoisomerase 4 subunit A parC 0.0236
6226 DNA topoisomerase 4 subunit A parC 0.0236
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0235
404 DNA gyrase subunit A gyrA 0.0233
6224 DNA gyrase subunit A gyrA 0.0233
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0232
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0231
6182 Cytochrome P450 2J2 CYP2J2 0.0229
341 5-hydroxytryptamine 3 receptor HTR3A 0.0229
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0226
6136 Multidrug resistance-associated protein 5 ABCC5 0.0223
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0222
6147 Solute carrier family 22 member 3 SLC22A3 0.0222
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0221
614 Progesterone receptor PGR 0.0219
833 Organic cation/carnitine transporter 1 SLC22A4 0.0215
725 5-hydroxytryptamine 1D receptor HTR1D 0.0215
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0214
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0209
468 Cytochrome P450 4A11 CYP4A11 0.0208
3923 Cholinesterase BCHE 0.0207
6020 Aldehyde oxidase AOX1 0.0201
789 Alpha-1D adrenergic receptor ADRA1D 0.0201
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0199
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0196
629 Alpha-2B adrenergic receptor ADRA2B 0.0195
6141 Sodium/bile acid cotransporter SLC10A1 0.019
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0189
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0187
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0182
16 Adenosine A1 receptor ADORA1 0.0181
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0181
378 Alpha-2C adrenergic receptor ADRA2C 0.018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.018
465 Calmodulin CALM1 0.0179
3939 Amine oxidase [flavin-containing] B MAOB 0.0177
737 Mineralocorticoid receptor NR3C2 0.0176
1178 Adenosine A2a receptor ADORA2A 0.0175
756 Sex hormone-binding globulin SHBG 0.0175
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0174
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0174
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0172
4148 Serine/threonine-protein kinase mTOR MTOR 0.0169
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0168
844 Epidermal growth factor receptor EGFR 0.0164
3947 Xanthine dehydrogenase/oxidase XDH 0.0164
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0163
4604 Liver carboxylesterase 1 CES1 0.0162
738 Monocarboxylate transporter 1 SLC16A1 0.016
4122 Histone deacetylase 2 HDAC2 0.016
124 Histamine H2 receptor HRH2 0.0158
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0158
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0157
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0157
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0156
232 Corticosteroid-binding globulin SERPINA6 0.0154
432 D(4) dopamine receptor DRD4 0.0152
6137 Multidrug resistance-associated protein 6 ABCC6 0.0152
146 Androgen receptor AR 0.0151
777 Tumor necrosis factor TNF 0.0148
4238 50S ribosomal protein L4 rplD 0.0146
5578 50S ribosomal protein L4 rplD 0.0146
6173 50S ribosomal protein L4 rplD 0.0146
6219 50S ribosomal protein L4 rplD 0.0146
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0145
504 Mast/stem cell growth factor receptor KIT 0.0144
26 Vascular endothelial growth factor receptor 3 FLT4 0.0143
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0141
122 P2Y purinoceptor 12 P2RY12 0.0141
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0141
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0137
29 Tubulin beta-1 chain TUBB1 0.0137
32 Vascular endothelial growth factor receptor 1 FLT1 0.0136
811 Translocator protein TSPO 0.0136
6220 Aryl hydrocarbon receptor AHR 0.0133
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0132
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.013
140 30S ribosomal protein S9 rpsI 0.013
6719 30S ribosomal protein S9 rpsI 0.013
6725 30S ribosomal protein S9 rpsI 0.013
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.013
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.013
407 Vascular endothelial growth factor receptor 2 KDR 0.0129
228 Beta platelet-derived growth factor receptor PDGFRB 0.0129
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0126
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0125
716 5-hydroxytryptamine 7 receptor HTR7 0.0124
273 Apoptosis regulator Bcl-2 BCL2 0.0123
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0122
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0122
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.012
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0118
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0118
4120 NADPH--cytochrome P450 reductase POR 0.0116
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
161 Tubulin beta chain TUBB 0.0115
312 Tubulin beta chain TUB2 0.0115
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0115
380 Cytochrome P450 17A1 CYP17A1 0.0114
22 30S ribosomal protein S4 rpsD 0.0113
6714 30S ribosomal protein S4 rpsD 0.0113
436 5-hydroxytryptamine 2B receptor HTR2B 0.0111
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0111
244 Angiotensin-converting enzyme ACE 0.0111
1852 Microtubule-associated protein 2 MAP2 0.0109
1656 CYP2B protein CYP2B 0.0108
427 Substance-P receptor TACR1 0.0107
869 Estrogen receptor beta ESR2 0.0107
6014 Cytochrome P450 2A13 CYP2A13 0.0107
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0107
1010 Cytochrome P450 51A1 CYP51A1 0.0106
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0106
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0105
952 Dipeptidyl peptidase 4 DPP4 0.0103
950 Alpha platelet-derived growth factor receptor PDGFRA 0.01
768 FK506-binding protein 1A FKBP1A 0.01
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
571 Melatonin receptor type 1A MTNR1A 0.0096
362 Melatonin receptor type 1B MTNR1B 0.0096
70 Type-1 angiotensin II receptor AGTR1 0.0095
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0093
1256 5-hydroxytryptamine 6 receptor HTR6 0.0093
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0091
5923 Microtubule-associated protein tau MAPT 0.0091
5924 Microtubule-associated protein 4 MAP4 0.0091
163 D(1B) dopamine receptor DRD5 0.0089
94 5-hydroxytryptamine 4 receptor HTR4 0.0089
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0089
474 Acetylcholinesterase ACHE 0.0089
159 Penicillin-binding protein 2B penA 0.0088
6121 Penicillin-binding protein 2B penA 0.0088
1192 Sulfotransferase 1A1 SULT1A1 0.0088
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0087
5353 Glutamate decarboxylase alpha gadA 0.0087
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0086
4773 Deoxycytidine kinase DCK 0.0086
284 DNA-directed RNA polymerase beta chain rpoB 0.0085
5773 DNA-directed RNA polymerase beta chain rpoB 0.0085
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0084
6149 Solute carrier family 22 member 10 SLC22A10 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0083
338 DNA polymerase UL30 0.0081
379 DNA polymerase UL54 0.0081
697 DNA polymerase ORF28 0.0081
2482 DNA polymerase 43 0.0081
4104 DNA polymerase BALF5 0.0081
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
373 Transthyretin TTR 0.0079
183 Vascular endothelial growth factor A VEGFA 0.0079
528 5-hydroxytryptamine 1E receptor HTR1E 0.0078
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1757 Myeloperoxidase MPO 0.0077
1867 Major prion protein PRNP 0.0077
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0077
165 FL cytokine receptor FLT3 0.0076
239 Coagulation factor X F10 0.0076
275 Arachidonate 5-lipoxygenase ALOX5 0.0076
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0075
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0075
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0075
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0075
1517 Beta-3 adrenergic receptor ADRB3 0.0074
705 Glutamate receptor 1 GRIA1 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
6102 Arylamine N-acetyltransferase 2 NAT2 0.0073
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0073
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0073
5300 Antigen peptide transporter 1 TAP1 0.0072
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0072
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0072
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0072
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0071
2449 Tubulin alpha-3 chain TUBA1A 0.007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0069
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0069
814 Ryanodine receptor 1 RYR1 0.0068
6043 Putative G-protein coupled receptor 44 GPR44 0.0067
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0067
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0067
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0066
6207 30S ribosomal protein S14 rpsN 0.0066
6209 30S ribosomal protein S19 rpsS 0.0066
6712 30S ribosomal protein S19 rpsS 0.0066
6726 30S ribosomal protein S19 rpsS 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0064
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0064
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0064
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0064
511 5-hydroxytryptamine 1F receptor HTR1F 0.0064
469 Annexin A1 ANXA1 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6044 Serum paraoxonase/lactonase 3 PON3 0.0063
3685 Catabolite gene activator crp 0.0063
4655 Adenylate cyclase cyaC 0.0063
4759 Adenylate cyclase cyaB2 0.0063
509 Thymidine kinase TK 0.0063
570 Thymidine kinase TK 0.0063
2559 Thymidine kinase TK 0.0063
3430 Thymidine kinase tdk 0.0063
3518 Thymidine kinase TK 0.0063
5301 Thymidine kinase tdk 0.0063
5771 Thymidine kinase ORF36 0.0063
7009 Thymidine kinase ORF36 0.0063
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0063
319 Opioid receptor, sigma 1 OPRS1 0.0062
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0062
24 Thymidylate synthase TMP1 0.0062
359 Thymidylate synthase TYMS 0.0062
2626 Thymidylate synthase thyA 0.0062
2729 Thymidylate synthase thyA 0.0062
5352 Thymidylate synthase THYA 0.0062
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.006
208 DNA-directed RNA polymerase beta' chain rpoC 0.006
5774 DNA-directed RNA polymerase beta' chain rpoC 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0059
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
921 Glutamate receptor 2 GRIA2 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
823 Fibroblast growth factor receptor 2 FGFR2 0.0058
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0058
1618 High affinity nerve growth factor receptor NTRK1 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0058
6432 Transporter snf 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0057
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0057
592 Carbonic anhydrase 4 CA4 0.0055
295 Carbonic anhydrase 1 CA1 0.0055
1196 Complement decay-accelerating factor CD55 0.0055
2249 Aspartate aminotransferase aspC 0.0054
2671 Aspartate aminotransferase aspC 0.0054
5490 Aspartate aminotransferase Not Available 0.0054
4760 Mll3241 protein mll3241 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0053
3957 Adenosine deaminase ADA 0.0053
365 Dihydrofolate reductase DHFR 0.0053
2381 Dihydrofolate reductase DFR1 0.0053
2833 Dihydrofolate reductase Not Available 0.0053
2931 Dihydrofolate reductase folA 0.0053
3544 Dihydrofolate reductase folA 0.0053
3682 Dihydrofolate reductase folA 0.0053
6642 Dihydrofolate reductase folA 0.0053
6756 Dihydrofolate reductase dfrA 0.0053
4311 tRNA TRDMT1 0.0053
4325 tRNA trmD 0.0053
4328 tRNA trmD 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
4217 Telomerase reverse transcriptase TERT 0.0052
49 Endothelin B receptor EDNRB 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
904 Glutathione S-transferase P GSTP1 0.0051
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0051
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0051
976 Platelet glycoprotein IX GP9 0.0051
6033 High affinity interleukin-8 receptor A CXCR1 0.0051
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0051
1050 Bile salt sulfotransferase SULT2A1 0.005
527 Prostacyclin receptor PTGIR 0.005
33 Cystine/glutamate transporter SLC7A11 0.005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.005
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0049
672 Prostaglandin F2-alpha receptor PTGFR 0.0049
558 Solute carrier family 12 member 1 SLC12A1 0.0048
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0048
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0048
54 Prothrombin F2 0.0048
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0048
2808 Chloramphenicol acetyltransferase 3 cat3 0.0047
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
3917 Methylenetetrahydrofolate reductase MTHFR 0.0046
6167 Organic solute transporter subunit beta OSTB 0.0046
84 Nuclear receptor 0B1 NR0B1 0.0046
6166 Organic solute transporter subunit alpha OSTA 0.0046
173 Toll-like receptor 7 TLR7 0.0046
867 Penicillin-binding protein 3 pbpC 0.0046
6119 Penicillin-binding protein 3 pbp3 0.0046
7154 Penicillin-binding protein 3 pbp3 0.0046
7157 Penicillin-binding protein 3 LMHCC_2184 0.0046
7162 Penicillin-binding protein 3 pbpB 0.0046
7172 Penicillin-binding protein 3 pbp3 0.0046
6085 Fatty acid-binding protein, intestinal FABP2 0.0046
6174 50S ribosomal protein L32 rpmF 0.0045
1654 Interleukin-1 beta IL1B 0.0045
780 Retinoic acid receptor RXR-gamma RXRG 0.0044
3809 Estrogen-related receptor gamma ESRRG 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
1630 Integrin beta-2 ITGB2 0.0043
3601 Dihydropteroate synthase 1 folP1 0.0043
3807 Dihydropteroate synthase 1 folP1 0.0043
3808 Dihydropteroate synthase 2 folP2 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0043
2417 Chloramphenicol acetyltransferase cat 0.0043
3278 Chloramphenicol acetyltransferase cat 0.0043
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0043
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
1039 Histone deacetylase 9 HDAC9 0.0043
2810 Dr hemagglutinin structural subunit draA 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
153 Dopamine beta-hydroxylase DBH 0.0042
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
856 Vitamin D3 receptor VDR 0.0042
663 Solute carrier family 12 member 4 SLC12A4 0.0042
53 Solute carrier family 12 member 5 SLC12A5 0.0042
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0042
3932 Glutathione S-transferase A2 GSTA2 0.0041
357 Carbonic anhydrase 2 CA2 0.0041
4226 Uridine phosphorylase 2 UPP2 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0041
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0041
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0041
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1629 Transcription factor AP-1 JUN 0.004
2320 Thymidine kinase, cytosolic TK1 0.004
88 Retinoic acid receptor RXR-beta RXRB 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
310 Solute carrier family 12 member 2 SLC12A2 0.0039
268 Adenosine A2b receptor ADORA2B 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0038
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
174 Sigma 1-type opioid receptor SIGMAR1 0.0038
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0038
85 Growth hormone receptor GHR 0.0038
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0038
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
1864 RET proto-oncogene RET 0.0037
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0037
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0037
4225 Uridine phosphorylase 1 UPP1 0.0037
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0037
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0037
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0036
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0036
494 Caspase-1 CASP1 0.0036
2112 Toll-like receptor 9 TLR9 0.0036
3856 Fibroblast growth factor receptor 3 FGFR3 0.0036
4203 Histamine N-methyltransferase HNMT 0.0036
413 Amidophosphoribosyltransferase PPAT 0.0035
2515 Amidophosphoribosyltransferase purF 0.0035
3714 Amidophosphoribosyltransferase purF 0.0035
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0035
6218 Pannexin-1 PANX1 0.0035
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0035
1507 Cytochrome c CYCS 0.0035
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
939 50S ribosomal protein L3 rplC 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0034
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0033
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0033
3760 Penicillin-binding protein 5 precursor dacA 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0032
572 Integrin alpha-L ITGAL 0.0032
645 Penicillin-binding protein 1A mrcA 0.0032
5805 Penicillin-binding protein 1A ponA 0.0032
6185 Penicillin-binding protein 1A mrcA 0.0032
6799 Penicillin-binding protein 1A pbpA 0.0032
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0032
3086 Plasmepsin-2 Not Available 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
518 Peroxidase/catalase T katG 0.0031
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
2981 Phospholipase A2, membrane associated PLA2G2A 0.0031
5787 Angiopoietin-1 receptor TEK 0.0031
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0031
1650 Heme carrier protein 1 SLC46A1 0.0031
162 Retinoic acid receptor gamma-1 RARG 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2077 Caspase-3 CASP3 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
106 Cannabinoid receptor 2 CNR2 0.003
6048 Troponin C, skeletal muscle TNNC2 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
482 Glycine receptor subunit alpha-1 GLRA1 0.0029
563 Thyroid peroxidase TPO 0.0029
819 Penicillin-binding protein 4 dacB 0.0029
891 Dihydropteroate synthase folP 0.0029
5359 Dihydropteroate synthase folP 0.0029
7175 Dihydropteroate synthase sulI 0.0029
3639 Thymidine phosphorylase deoA 0.0029
3936 Thymidine phosphorylase TYMP 0.0029
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
6042 Prostaglandin reductase 2 PTGR2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
7 Nitric oxide synthase, inducible NOS2 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
115 Penicillin-binding protein 2 mrdA 0.0027
6069 Penicillin-binding protein 2 mrdA 0.0027
6118 Penicillin-binding protein 2 penA 0.0027
6187 Penicillin-binding protein 2 pbpA 0.0027
6686 Penicillin-binding protein 2 pbp2 0.0027
6939 Penicillin-binding protein 2 mrdA 0.0027
7163 Penicillin-binding protein 2 pbpA 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0026
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0026
489 Monocarboxylate transporter 2 SLC16A7 0.0026
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1648 Elastin ELN 0.0026
517 Alcohol dehydrogenase 1C ADH1C 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
543 Penicillin-binding protein 1B mrcB 0.0026
6186 Penicillin-binding protein 1B ponB 0.0026
6822 Penicillin-binding protein 1b pbp1b 0.0026
6844 Penicillin-binding protein 1b pbp1b 0.0026
1 Peptidoglycan synthetase ftsI ftsI 0.0025
4155 Peptidoglycan synthetase ftsI ftsI 0.0025
6859 Protein S100-A4 S100A4 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
3810 Catechol O-methyltransferase COMT 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0025
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0024
581 Cytochrome P450 2R1 CYP2R1 0.0024
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0024
5818 Folate receptor alpha FOLR1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
6070 Nischarin NISCH 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
2391 Ferrochelatase hemH 0.0022
6502 Ferrochelatase DKFZp686P18130 0.0022
1591 Ferrochelatase, mitochondrial FECH 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
1313 Lactoylglutathione lyase GLO1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
332 Beta-lactamase blaZ 0.0021
2478 Beta-lactamase ampC 0.0021
2613 Beta-lactamase ampC 0.0021
2635 Beta-lactamase ampC 0.0021
2700 Beta-lactamase penP 0.0021
5445 Beta-lactamase blaB 0.0021
6019 Beta-lactamase SHV-7 0.0021
6701 Beta-lactamase cphA 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
3587 Gastrotropin FABP6 0.0021
2091 Endoplasmin HSP90B1 0.0021
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
293 Gamma-glutamyl hydrolase GGH 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0019
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0019
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0019
6493 Cytochrome c oxidase subunit 6C COX6C 0.0019
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0019
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0019
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0019
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0019
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0019
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0019
6558 Cytochrome c oxidase subunit 1 ctaD 0.0019
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0019
6559 Cytochrome c oxidase subunit 2 ctaC 0.0019
6669 Cytochrome c oxidase subunit 2 ctaC 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0018
1253 Interferon gamma IFNG 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3830 Calreticulin CALR 0.0017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0017
2540 Choloylglycine hydrolase cbh 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
229 Retinoic acid receptor beta RARB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6501 Fatty acid-binding protein, liver FABP1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0016
3937 Fatty-acid amide hydrolase FAAH 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
1243 Cathepsin D CTSD 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
164 Histamine H4 receptor HRH4 0.0016
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0015
6755 Poliovirus receptor PVR 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
702 UMP-CMP kinase CMPK1 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0015
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0015
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6500 Phospholipase A2 PLA2G1B 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
1992 Vitamin D-binding protein GC 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2021 Thrombomodulin THBD 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6459 Glycodelin PAEP 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.0009
6165 Copper-transporting ATPase 1 ATP7A 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
798 Osteocalcin BGLAP 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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