DT-Web

DB00673 - Aprepitant


Identification
Name Aprepitant
Accession Number DB00673 (APRD00100)
Type small molecule
Description Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 534.4267
Groups approved
Monoisotopic Weight 534.150187993
Pharmacology
Indication For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including high-dose cisplatin (in combination with other antiemetic agents).
Mechanism of action Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with Aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies show that Aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid ethasone and inhibits both the acute and delayed phases of cisplatin induced emesis.
Absorption The mean absolute oral bioavailability of aprepitant is approximately 60 to 65%.
Protein binding >95%
Biotransformation Aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19. Seven metabolites of aprepitant, which are only weakly active, have been identified in human plasma.
Route of elimination Aprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted. Aprepitant is excreted in the milk of rats. It is not known whether this drug is excreted in human milk.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Aprepitant may decrease the anticoagulant effect of acenocoumarol by decreasing its serum concentration.
Alprazolam Aprepitant may increase the effect and toxicity of the benzodiazepine, alprazolam.
Anisindione Aprepitant may decrease the anticoagulant effect of anisindione by decreasing its serum concentration.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Carbamazepine The CYP3A4 inducer, carbamazepine, may decrease the effect of aprepitant.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin The CYP3A4 inhibitor, clarithromycin, may increase the effect and toxicity of aprepitant.
Corticotropin Aprepitant may increase the serum concentration of Corticosteroids (Systemic). Monitor for increased effects of systemic corticosteroids when coadmininistered with aprepitant; corticosteroid dose reduction may be necessary. The manufacturer of fosaprepitant (a prodrug of aprepitant) states that oral dexamethasone doses should be reduced by 50% when coadministered with a fosaprepitant/aprepitant regimen to achieve dexamethasone concentrations similar to those achieved with dexamethasone alone. Dexamethasone doses used in clinical chemotherapy nausea/vomiting studies with aprepitant reflect this 50% decrease. Similarly, it is recommended that in order to achieve concentrations similar to those achieved with methylprednisolone alone, the intravenous methylprednisolone dose should be reduced by 25% and the oral methylprednisolone dose should be reduced by 50% when given together with a fosaprepitant/aprepitant regimen.
Dexamethasone Aprepitant may increase the effect and toxicity of dexamethasone.
Dicumarol Aprepitant may decrease the anticoagulant effect of dicumarol by decreasing its serum concentration.
Diltiazem This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Docetaxel Aprepitant may change levels of the chemotherapy agent, docetaxel.
Erythromycin Erythromycin, a moderate CYP3A4 inhibitor, may increase the effect and toxicity of aprepitant.
Ethinyl Estradiol Aprepitant could decrease the effect of the oral contraceptive
Ethotoin The CYP3A4 inducer, ethotoin, may decrease the effect of aprepitant.
Etoposide Aprepitant may change levels of the chemotherapy agent, etoposide.
Fosphenytoin The CYP3A4 inducer, fosphenytoin, may decrease the effect of aprepitant.
Ifosfamide Aprepitant may change levels of the chemotherapy agent, ifosfamide.
Imatinib Aprepitant may change levels of the chemotherapy agent, imatinib.
Irinotecan Aprepitant may change levels of the chemotherapy agent, irinotecan.
Itraconazole This CYP3A4 inhibitor, itraconazole, may increase the effect and toxicity of aprepitant.
Ketoconazole This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Mephenytoin The CYP3A4 inducer, mephenytoin, may decrease the effect of aprepitant.
Mestranol Aprepitant could decrease the effect of the oral contraceptive
Methylprednisolone Increases the effect and toxicity of methylprednisolone
Midazolam Aprepitant may increase the effect and toxicity of the benzodiazepine, midazolam.
Nefazodone This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Nelfinavir This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Paclitaxel Aprepitant may change levels of the chemotherapy agent, paclitaxel.
Phenytoin The CYP3A4 inducer, phenytoin, may decrease the effect of aprepitant.
Pimozide Increased risk of cardiotoxicity and arrhythmias
Rifampin The CYP3A4 inducer, rifampin, may decrease the effect of aprepitant.
Ritonavir This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Tamsulosin Aprepitant, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Aprepitant is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may reduce clearance of Aprepitant. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Aprepitant if Telithromycin is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tolterodine Aprepitant may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Aprepitant may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Aprepitant, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Aprepitant is initiated, discontinued or dose changed.
Triazolam Aprepitant may increase the effect and toxicity of the benzodiazepine, triazolam.
Troleandomycin This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Vinblastine Aprepitant may change levels of the chemotherapy agent, vinblastine.
Vincristine Aprepitant may change levels of the chemotherapy agent, vincristine.
Vinorelbine Aprepitant may change levels of the chemotherapy agent, vinorelbine.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of aprepitant by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of aprepitant if voriconazole is initiated, discontinued or dose changed.
Warfarin Aprepitant may decrease the anticoagulant effect of warfarin by decreasing its serum concentration.
Food Interactions
  • Take without regard to meals.

Targets


Substance-P receptor
Name Substance-P receptor
Gene Name TACR1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Brands KM, Payack JF, Rosen JD, Nelson TD, Candelario A, Huffman MA, Zhao MM, Li J, Craig B, Song ZJ, Tschaen DM, Hansen K, Devine PN, Pye PJ, Rossen K, Dormer PG, Reamer RA, Welch CJ, Mathre DJ, Tsou NN, McNamara JM, Reider PJ: Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation. J Am Chem Soc. 2003 Feb 26;125(8):2129-35. - Pubmed
  • Rodgers J, Bradley B, Kennedy PG: Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. Parasitol Int. 2007 Dec;56(4):321-4. Epub 2007 Jun 29. - Pubmed
  • Poli-Bigelli S, Rodrigues-Pereira J, Carides AD, Julie Ma G, Eldridge K, Hipple A, Evans JK, Horgan KJ, Lawson F: Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer. 2003 Jun 15;97(12):3090-8. - Pubmed
  • Zhao MM, McNamara JM, Ho GJ, Emerson KM, Song ZJ, Tschaen DM, Brands KM, Dolling UH, Grabowski EJ, Reider PJ, Cottrell IF, Ashwood MS, Bishop BC: Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction. J Org Chem. 2002 Sep 20;67(19):6743-7. - Pubmed
  • Bergstrom M, Hargreaves RJ, Burns HD, Goldberg MR, Sciberras D, Reines SA, Petty KJ, Ogren M, Antoni G, Langstrom B, Eskola O, Scheinin M, Solin O, Majumdar AK, Constanzer ML, Battisti WP, Bradstreet TE, Gargano C, Hietala J: Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry. 2004 May 15;55(10):1007-12. - Pubmed
DTHybrid score 0.3196

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. - Pubmed
DTHybrid score 0.6572
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
DTHybrid score 0.4065
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
DTHybrid score 0.3265
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4171
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4133
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4684

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2943
1588 Multidrug resistance protein 1 ABCB1 0.2506
4924 Cytochrome P450 2C8 CYP2C8 0.2458
6030 Cytochrome P450 2B6 CYP2B6 0.1776
3872 Somatostatin receptor type 5 SSTR5 0.1385
6008 Somatostatin receptor type 2 SSTR2 0.1385
6013 Cytochrome P450 2E1 CYP2E1 0.138
6024 Cytochrome P450 1A1 CYP1A1 0.1132
20 Prostaglandin G/H synthase 1 PTGS1 0.1045
5718 Cytochrome P450 2A6 CYP2A6 0.0888
587 Serum albumin ALB 0.0839
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0798
831 D(2) dopamine receptor DRD2 0.0598
6106 Cytochrome P450 2C18 CYP2C18 0.0593
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0571
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0564
492 Histamine H1 receptor HRH1 0.0546
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0491
862 Multidrug resistance-associated protein 1 ABCC1 0.0482
824 Sodium-dependent serotonin transporter SLC6A4 0.0465
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0462
3811 Cytochrome P450 19A1 CYP19A1 0.0434
290 Prostaglandin G/H synthase 2 PTGS2 0.0432
1729 Solute carrier family 22 member 6 SLC22A6 0.043
6145 Solute carrier family 22 member 1 SLC22A1 0.0426
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.042
502 5-hydroxytryptamine 2A receptor HTR2A 0.0401
1898 Cytochrome P450 1B1 CYP1B1 0.0389
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0377
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0374
847 Mu-type opioid receptor OPRM1 0.0361
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0361
6031 Cytochrome P450 3A43 CYP3A43 0.036
6144 Solute carrier family 22 member 2 SLC22A2 0.0356
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0349
556 Alpha-1A adrenergic receptor ADRA1A 0.0344
320 5-hydroxytryptamine 1A receptor HTR1A 0.0336
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0335
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0324
318 Alpha-2A adrenergic receptor ADRA2A 0.0323
776 Bile salt export pump ABCB11 0.032
731 HIV-1 protease HIV-1 protease 0.0311
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0304
871 Glucocorticoid receptor NR3C1 0.0302
260 Cytochrome P450 51 ERG11 0.0301
761 Cytochrome P450 51 ERG11 0.0301
3163 Cytochrome P450 51 cyp51 0.0301
341 5-hydroxytryptamine 3 receptor HTR3A 0.0282
136 Estrogen receptor ESR1 0.0277
590 5-hydroxytryptamine 2C receptor HTR2C 0.0276
6143 Solute carrier family 22 member 7 SLC22A7 0.0275
23 D(1A) dopamine receptor DRD1 0.0273
713 Sodium-dependent dopamine transporter SLC6A3 0.0266
817 DNA topoisomerase 2-alpha TOP2A 0.0261
467 Delta-type opioid receptor OPRD1 0.0259
36 Insulin receptor INSR 0.0258
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0258
632 Alpha-1B adrenergic receptor ADRA1B 0.0257
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.025
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0249
3941 Amine oxidase [flavin-containing] A MAOA 0.0248
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0247
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0246
118 Organic cation/carnitine transporter 2 SLC22A5 0.0242
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0241
6142 Solute carrier family 22 member 8 SLC22A8 0.0241
766 Beta-2 adrenergic receptor ADRB2 0.0239
2164 Multidrug resistance-associated protein 4 ABCC4 0.0237
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0236
696 Kappa-type opioid receptor OPRK1 0.0236
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0233
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0233
638 D(3) dopamine receptor DRD3 0.0231
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0226
885 5-hydroxytryptamine 1B receptor HTR1B 0.0226
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0225
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0218
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0213
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0212
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.021
468 Cytochrome P450 4A11 CYP4A11 0.0205
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0202
477 DNA topoisomerase 4 subunit A parC 0.0201
886 DNA topoisomerase 4 subunit A parC 0.0201
6226 DNA topoisomerase 4 subunit A parC 0.0201
6182 Cytochrome P450 2J2 CYP2J2 0.02
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.02
404 DNA gyrase subunit A gyrA 0.0198
6224 DNA gyrase subunit A gyrA 0.0198
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0197
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0194
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0194
614 Progesterone receptor PGR 0.0192
725 5-hydroxytryptamine 1D receptor HTR1D 0.0186
3939 Amine oxidase [flavin-containing] B MAOB 0.0185
6147 Solute carrier family 22 member 3 SLC22A3 0.0185
629 Alpha-2B adrenergic receptor ADRA2B 0.0181
6148 Multidrug resistance-associated protein 7 ABCC10 0.018
122 P2Y purinoceptor 12 P2RY12 0.0179
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0176
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0174
193 Beta-1 adrenergic receptor ADRB1 0.0174
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0171
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0171
789 Alpha-1D adrenergic receptor ADRA1D 0.0169
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0168
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0167
378 Alpha-2C adrenergic receptor ADRA2C 0.0165
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0165
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0164
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0164
465 Calmodulin CALM1 0.0163
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0163
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0158
811 Translocator protein TSPO 0.0158
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0157
737 Mineralocorticoid receptor NR3C2 0.0156
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0155
833 Organic cation/carnitine transporter 1 SLC22A4 0.0154
432 D(4) dopamine receptor DRD4 0.0151
6220 Aryl hydrocarbon receptor AHR 0.0149
146 Androgen receptor AR 0.0147
4148 Serine/threonine-protein kinase mTOR MTOR 0.0145
756 Sex hormone-binding globulin SHBG 0.0145
232 Corticosteroid-binding globulin SERPINA6 0.0143
777 Tumor necrosis factor TNF 0.0139
818 50S ribosomal protein L10 rplJ 0.0139
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0138
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0133
70 Type-1 angiotensin II receptor AGTR1 0.0133
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0133
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
891 Dihydropteroate synthase folP 0.0132
5359 Dihydropteroate synthase folP 0.0132
7175 Dihydropteroate synthase sulI 0.0132
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0132
3923 Cholinesterase BCHE 0.0128
844 Epidermal growth factor receptor EGFR 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
504 Mast/stem cell growth factor receptor KIT 0.0126
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0125
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0125
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0125
407 Vascular endothelial growth factor receptor 2 KDR 0.0124
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0122
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0122
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0122
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0122
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0122
26 Vascular endothelial growth factor receptor 3 FLT4 0.0121
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0121
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.012
32 Vascular endothelial growth factor receptor 1 FLT1 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
228 Beta platelet-derived growth factor receptor PDGFRB 0.0113
94 5-hydroxytryptamine 4 receptor HTR4 0.0113
716 5-hydroxytryptamine 7 receptor HTR7 0.0112
124 Histamine H2 receptor HRH2 0.0112
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0111
6136 Multidrug resistance-associated protein 5 ABCC5 0.011
4604 Liver carboxylesterase 1 CES1 0.011
1010 Cytochrome P450 51A1 CYP51A1 0.0108
16 Adenosine A1 receptor ADORA1 0.0106
6137 Multidrug resistance-associated protein 6 ABCC6 0.0106
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0104
1656 CYP2B protein CYP2B 0.0104
1757 Myeloperoxidase MPO 0.0103
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0103
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0102
6014 Cytochrome P450 2A13 CYP2A13 0.0101
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0101
380 Cytochrome P450 17A1 CYP17A1 0.01
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.01
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0099
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0099
29 Tubulin beta-1 chain TUBB1 0.0098
6020 Aldehyde oxidase AOX1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6102 Arylamine N-acetyltransferase 2 NAT2 0.0096
49 Endothelin B receptor EDNRB 0.0096
1178 Adenosine A2a receptor ADORA2A 0.0092
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0092
1256 5-hydroxytryptamine 6 receptor HTR6 0.0091
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.009
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.009
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
273 Apoptosis regulator Bcl-2 BCL2 0.009
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0089
6141 Sodium/bile acid cotransporter SLC10A1 0.0089
295 Carbonic anhydrase 1 CA1 0.0088
4120 NADPH--cytochrome P450 reductase POR 0.0088
163 D(1B) dopamine receptor DRD5 0.0088
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0086
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0085
436 5-hydroxytryptamine 2B receptor HTR2B 0.0085
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0085
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0084
161 Tubulin beta chain TUBB 0.0083
312 Tubulin beta chain TUB2 0.0083
869 Estrogen receptor beta ESR2 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0081
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0081
2539 Tubulin alpha-1 chain TUBA4A 0.0081
158 Sodium channel protein type 1 subunit alpha SCN1A 0.008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0079
705 Glutamate receptor 1 GRIA1 0.0079
4237 50S ribosomal protein L22 rplV 0.0079
4122 Histone deacetylase 2 HDAC2 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0078
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0078
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
528 5-hydroxytryptamine 1E receptor HTR1E 0.0077
208 DNA-directed RNA polymerase beta' chain rpoC 0.0075
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0075
4116 Dihydropteroate synthetase Not Available 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
3947 Xanthine dehydrogenase/oxidase XDH 0.0071
921 Glutamate receptor 2 GRIA2 0.0071
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0071
275 Arachidonate 5-lipoxygenase ALOX5 0.0071
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.007
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.007
952 Dipeptidyl peptidase 4 DPP4 0.0069
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0069
814 Ryanodine receptor 1 RYR1 0.0069
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0068
284 DNA-directed RNA polymerase beta chain rpoB 0.0068
5773 DNA-directed RNA polymerase beta chain rpoB 0.0068
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0067
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0067
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0066
165 FL cytokine receptor FLT3 0.0065
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0065
54 Prothrombin F2 0.0065
1196 Complement decay-accelerating factor CD55 0.0065
4238 50S ribosomal protein L4 rplD 0.0065
5578 50S ribosomal protein L4 rplD 0.0065
6173 50S ribosomal protein L4 rplD 0.0065
6219 50S ribosomal protein L4 rplD 0.0065
239 Coagulation factor X F10 0.0064
6044 Serum paraoxonase/lactonase 3 PON3 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
373 Transthyretin TTR 0.0063
133 Dihydropterate synthase sulI 0.0063
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0063
823 Fibroblast growth factor receptor 2 FGFR2 0.0063
3810 Catechol O-methyltransferase COMT 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
153 Dopamine beta-hydroxylase DBH 0.0062
183 Vascular endothelial growth factor A VEGFA 0.0062
365 Dihydrofolate reductase DHFR 0.0062
2381 Dihydrofolate reductase DFR1 0.0062
2833 Dihydrofolate reductase Not Available 0.0062
2931 Dihydrofolate reductase folA 0.0062
3544 Dihydrofolate reductase folA 0.0062
3682 Dihydrofolate reductase folA 0.0062
6642 Dihydrofolate reductase folA 0.0062
6756 Dihydrofolate reductase dfrA 0.0062
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0061
474 Acetylcholinesterase ACHE 0.0061
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0061
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0061
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
1517 Beta-3 adrenergic receptor ADRB3 0.0059
1852 Microtubule-associated protein 2 MAP2 0.0059
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0058
1618 High affinity nerve growth factor receptor NTRK1 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
780 Retinoic acid receptor RXR-gamma RXRG 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
738 Monocarboxylate transporter 1 SLC16A1 0.0056
2808 Chloramphenicol acetyltransferase 3 cat3 0.0056
5300 Antigen peptide transporter 1 TAP1 0.0056
469 Annexin A1 ANXA1 0.0056
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0055
511 5-hydroxytryptamine 1F receptor HTR1F 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0054
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0054
482 Glycine receptor subunit alpha-1 GLRA1 0.0054
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0054
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0053
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
6085 Fatty acid-binding protein, intestinal FABP2 0.0053
33 Cystine/glutamate transporter SLC7A11 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
5923 Microtubule-associated protein tau MAPT 0.0053
5924 Microtubule-associated protein 4 MAP4 0.0053
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
88 Retinoic acid receptor RXR-beta RXRB 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3601 Dihydropteroate synthase 1 folP1 0.0052
3807 Dihydropteroate synthase 1 folP1 0.0052
3808 Dihydropteroate synthase 2 folP2 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0051
976 Platelet glycoprotein IX GP9 0.0051
84 Nuclear receptor 0B1 NR0B1 0.0051
2810 Dr hemagglutinin structural subunit draA 0.0051
1050 Bile salt sulfotransferase SULT2A1 0.005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
4311 tRNA TRDMT1 0.0049
4325 tRNA trmD 0.0049
4328 tRNA trmD 0.0049
856 Vitamin D3 receptor VDR 0.0047
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0047
4203 Histamine N-methyltransferase HNMT 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
6174 50S ribosomal protein L32 rpmF 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
319 Opioid receptor, sigma 1 OPRS1 0.0046
173 Toll-like receptor 7 TLR7 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0045
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0045
6432 Transporter snf 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0045
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0044
1630 Integrin beta-2 ITGB2 0.0044
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0043
518 Peroxidase/catalase T katG 0.0043
4773 Deoxycytidine kinase DCK 0.0043
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0042
1192 Sulfotransferase 1A1 SULT1A1 0.0042
1648 Elastin ELN 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
5251 Carbonyl reductase [NADPH] 1 CBR1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
904 Glutathione S-transferase P GSTP1 0.004
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.004
563 Thyroid peroxidase TPO 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
1541 Metalloproteinase mmp20 0.0039
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
174 Sigma 1-type opioid receptor SIGMAR1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0038
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0038
85 Growth hormone receptor GHR 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
1864 RET proto-oncogene RET 0.0037
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0037
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0037
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0037
1629 Transcription factor AP-1 JUN 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
6146 High affinity copper uptake protein 1 SLC31A1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0033
3809 Estrogen-related receptor gamma ESRRG 0.0033
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0033
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0033
3932 Glutathione S-transferase A2 GSTA2 0.0033
572 Integrin alpha-L ITGAL 0.0033
581 Cytochrome P450 2R1 CYP2R1 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0032
3086 Plasmepsin-2 Not Available 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4192 DNA topoisomerase 2-beta TOP2B 0.0031
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
6048 Troponin C, skeletal muscle TNNC2 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
719 Retinoic acid receptor responder protein 1 RARRES1 0.003
770 Retinoic acid-induced protein 3 GPRC5A 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0029
3957 Adenosine deaminase ADA 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
162 Retinoic acid receptor gamma-1 RARG 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
5787 Angiopoietin-1 receptor TEK 0.0026
7 Nitric oxide synthase, inducible NOS2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
5880 Thrombopoietin receptor MPL 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
6149 Solute carrier family 22 member 10 SLC22A10 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0025
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
2112 Toll-like receptor 9 TLR9 0.0025
537 ATP synthase delta chain, mitochondrial ATP5D 0.0025
164 Histamine H4 receptor HRH4 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0024
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0024
1039 Histone deacetylase 9 HDAC9 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
131 Synaptic vesicular amine transporter SLC18A2 0.0023
1830 5'-nucleotidase NT5E 0.0023
908 Glutathione S-transferase theta-1 GSTT1 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
6506 Stathmin-4 STMN4 0.0021
444 Alcohol dehydrogenase 1B ADH1B 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0021
2091 Endoplasmin HSP90B1 0.0021
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0021
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0021
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0021
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1992 Vitamin D-binding protein GC 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0019
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0019
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
517 Alcohol dehydrogenase 1C ADH1C 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0018
1253 Interferon gamma IFNG 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
1243 Cathepsin D CTSD 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
268 Adenosine A2b receptor ADORA2B 0.0015
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0014
1341 Histamine H3 receptor HRH3 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6859 Protein S100-A4 S100A4 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
6218 Pannexin-1 PANX1 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
2021 Thrombomodulin THBD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
2298 Cytochrome P450-cam camC 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
125 DNA polymerase beta POLB 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
3221 Cytochrome c4 cc4 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
1507 Cytochrome c CYCS 0.0005
2207 Rhodopsin RHO 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
798 Osteocalcin BGLAP 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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