DT-Web: DB00564

Identification

Name

Carbamazepine

Accession Number

DB00564 (APRD00337)

Type

small molecule

Description

An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

236.2686

Groups

approved

Monoisotopic Weight

236.094963016

Pharmacology

Indication

For the treatment of epilepsy and pain associated with true trigeminal neuralgia.

Mechanism of action

Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transmission in the trigeminal nucleus and seizure control with reduction of post-tetanic potentiation of synaptic transmission in the spinal cord. Carbamazepine also possesses anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant, antidepressant (possibly through blockade of norepinephrine release), sedative, and neuromuscular-blocking properties.

Absorption

In clinical studies, carbamazepine suspension, conventional tablets, and extended-release tablets delivered equivalent amounts of drug to the systemic circulation. However, it has been observed that the suspension is somewhat faster absorbed. Furthermore, the extended-release tablet is slightly slower than the conventional tablet. The bioavailability of the extended-release tablet is 89%, compared to the suspension. Plasma levels of carbamazepine are variable. The time to peak concentration for the different formulations are as follows: Suspension = 1.5 hours; Conventional tablets = 4-5 hours; Extended-release tablets = 3-12 hours.

Protein binding

76% bound to plasma proteins.

Biotransformation

Hepatic. CYP3A4 is the primary isoform responsible for the formation of carbamazepine-10,11-epoxide. This metabolite is active and shown to be equipotent to carbamazepine as an anticonvulsant. Carbamazepine is more rapidly metabolized to the aforementioned metabolite in younger patients than in adults. It also undergoes glucuronidation via UGT2B7, however this finding has been disputed.

Route of elimination

72% of the dose is in the urine while 28% is in the feces. Hydroxylated and conjugated metabolites are largely what was recovered in the urine. 3% of the dose is recovered as unchanged carbamazepine.

Toxicity

Mild ingestions cause vomiting, drowsiness, ataxia, slurred speech, nystagmus, dystonic reactions, and hallucinations. Severe intoxications may produce coma, seizures, respiratory depression, and hypotension

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abiraterone	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol	Carbamazepine may decrease the anticoagulant effect of acenocoumarol by decreasing its serum concentration.
Alprazolam	Carbamazepine may decrease the effect of the benzodiazepine, alprazolam.
Aminophylline	Carbamazepine may decrease the serum concentration of aminophylline. Aminophylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Amitriptyline	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, amitriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if carbamazepine is initiated, discontinued or dose changed.
Anisindione	Carbamazepine may decrease the anticoagulant effect of anisindione by decreasing its serum concentration.
Aprepitant	The CYP3A4 inducer, carbamazepine, may decrease the effect of aprepitant.
Aripiprazole	Carbamazepine, a strong CYP3A4 inducer, may decrease the serum concentration of aripiprazole by increasing its metabolism.
Asenapine	Carbamazepine is a CYP1A2 inducer that decreases asenapine's exposure by 20%.
Atorvastatin	Carbamazepine, a p-glycoprotein inducer and strong CYP3A4 inducer, may decrease the effect of atorvastatin by increasing its efflux and metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if carbamazepine is initiated, discontinued or dose changed.
Atracurium	Decreases the effect of muscle relaxant
Bendamustine	Decreases levels of bendamustine by affecting CYP1A2 hepatic enzyme metabolism. May increase concentrations of active metabolites.
Boceprevir	Strong CYP3A4 inducers will decrease levels of boceprevir. Concomitant therapy is contraindicated.
Bupropion	Carbamazepine, a strong CYP2B6 inducer, may increase the metabolism of bupropion. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bupropion if carbamazepine is initiated, discontinued or dose changed.
Cabazitaxel	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Cimetidine	Cimetidine may increase the serum concentration of carbamazepine during the first few days of concomitant therapy. Monitor for changes in the therapeutic and adverse effects of carbamazepine if cimetidine is initiated, discontinued or dose changed.
Clarithromycin	Clarithromycin may decrease the metabolism of carbamazepine. Monitor for changes in the therapeutic or adverse effects of carbamazepine if clarithromycin is initiated, discontinued or dose changed.
Clozapine	Carbamazepine may decrease the serum concentration of clozapine by increasing its metabolism. Concomitant therapy should also be avoided due to increased risk of bone marrow suppression. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of clozapine if carbamazepine is initiated, discontinued or dose changed.
Cyclosporine	Carbamazepine may decrease the therapeutic effect of cyclosporine.
Dabigatran etexilate	P-Glycoprotein inducers such as carbamazepine may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Dabrafenib	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Danazol	Danazol may decrease the metabolism of carbamazepine. Monitor for changes in the therapeutic and adverse effects of carbamazepine if danazol is initiated, discontinued or dose changed.
Delavirdine	The anticonvulsant, carbamazepine, decreases the effect of delavirdine.
Desipramine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, desipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if carbamazepine is initiated, discontinued or dose changed.
Dicumarol	Carbamazepine may decrease the anticoagulant effect of dicumarol by decreasing its serum concentration.
Diltiazem	Carbamazepine may decrease the serum concentration of diltiazem by increasing its metabolism. Diltiazem may increase the serum concentration of carbamazepine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if dosages are changed.
Doxacurium chloride	Decreases the effect of muscle relaxant
Doxepin	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, doxepin, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if carbamazepine is initiated, discontinued or dose changed.
Doxycycline	The anticonvulsant, carbamazepine, may decrease the therapeutic effect of doxycycline.
Dyphylline	Carbamazepine may decrease the serum concentration of diphylline. Diphylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Eltrombopag	Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Erythromycin	The macrolide, erythromycin, may increase the effect of carbamazepine.
Estradiol valerate/Dienogest	Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Ethinyl Estradiol	Carbamazepine may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be relied on alone during concomitant therapy with carbamazepine.
Etravirine	Carbamazepine, when used concomitantly with certain NNRTIs (ie. efavirenz), may experience a decrease in serum concentration. Etravirine, and other NNRTIs, when used concomitantly with carbamazepine, may experience an increase in serum concentration. It is recommended to avoid this combination.
Ezogabine	Ezogabine increases the clearance of carbamazepine (30%). The mechanism of this interaction is unknown.
Felbamate	Decreased effect of both products
Felodipine	Carbamazepine may increase the metabolism of felodipine. Monitor for changes in the therapeutic and adverse effects of felodipine if carbamazepine is initiated, discontinued or dose changed.
Fluconazole	Fluconazole may increase the therapeutic and adverse effects of carbamazepine.
Fluoxetine	Carbamazepine may decrease the serum concentration of fluoxetine by increasing its metabolism. Fluoxetine may increase the serum concentration of carbamazepine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or doses are changed.
Fluvoxamine	Fluvoxamine increases the effect of carbamazepine
Gefitinib	The CYP3A4 inducer, carbamazepine, may decrease the serum concentration and therapeutic effects of gefitinib.
Haloperidol	Carbamazepine may decrease the serum concentration of haloperidol by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of haloperidol if carbamazepine is initiated, discontinued or dose changed.
Imatinib	Carbamazepine, a strong CYP3A4 inducer, may increase the metabolism of imatinib. Imatinib, a strong CYP3A4 inhibitor, may increase the metabolism of carbamazepine. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed.
Imipramine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, imipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if carbamazepine is initiated, discontinued or dose changed.
Indinavir	Indinavir increases the effect and toxicity of carbamazepine
Isoniazid	Carbamazepine effect is increased as is isoniazid toxicity
Isotretinoin	Isotretinoine decreases the effect of carbamazepine
Itraconazole	Itraconazole may increase the effect of carbamazepine.
Ivacaftor	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Josamycin	The macrolide, josamycin, may increase the effect of carbamazepine.
Ketoconazole	Ketoconazole may increase the effect of carbamazepine.
Lamotrigine	Lamotrigine may increase the adverse effects of carbamazepine by increasing the concentration of its active metabolite, carbamazepine-epoxide. Carbamazepine may decrease the therapeutic effect of lamotrigine by increasing its metabolism. Lamotrigine doses should be adjusted accordingly. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinue or doses are changed.
Levetiracetam	Concomitant therapy may results in additive adverse CNS effects.
Levonorgestrel	Carbamazepine may decrease the contraceptive effect of levonorgestrel.
Linagliptin	CYP3A4 and p-glycoprotein inducers may decreases levels of linagliptin. Monitor concomitant therapy closely.
Lovastatin	Carbamazepine, a p-glycoprotein inducer and strong CYP3A4 inducer, may decrease the effect of lovastatin by increasing its efflux and metabolism. Monitor for changes in the therapeutic and adverse effects of lovastatin if carbamazepine is initiated, discontinued or dose changed.
Lurasidone	Concomitant therapy with a CYP3A4 inducer will decrease levels of lurasidone. Coadministration with lurasidone is contraindicated.
Mestranol	This product may cause a slight decrease of contraceptive effect
Methadone	Carbamazepine may decrease the serum level of methadone. Monitor for changes in the therapeutic and adverse effects of methadone if carbamazepine is initiated, discontinued or dose changed.
Methylphenidate	Carbamazepine may decrease the effect of methylphendiate.
Metocurine	Decreases the effect of muscle relaxant
Metronidazole	Metronidazole increases the effect of carbamazepine
Midazolam	Carbamazepine may decrease the effect of the benzodiazepine, midazolam.
Mivacurium	Decrease the effect of muscle relaxant
Nefazodone	Nefazodone increases the effect of carbamazepine
Norethindrone	This product may cause a slight decrease of contraceptive effect
Nortriptyline	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, nortriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if carbamazepine is initiated, discontinued or dose changed.
Oxtriphylline	Carbamazepine may decrease the serum concentration of oxtriphylline. Oxtriphylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Oxybutynin	Oxybutynin may cause carbamazepine toxicity
Pancuronium	Decreases the effect of muscle relaxant
Pazopanib	Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Ponatinib	Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Ponatinib	Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Praziquantel	Markedly lower praziquantel levels
Propoxyphene	Propoxyphene increases the effect of carbamazepine
Quinupristin	This combination presents an increased risk of toxicity
Regorafenib	Strong CYP3A4 inducers may decrease levels of regorafenib.
Rilpivirine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Risperidone	Decreases the effect of risperidone
Ritonavir	Ritonavir increases the effect of carbamazepine
Roflumilast	Affects CYP3A4 metabolism, decreases level or effect of roflumilast. Also decreases the level or effect of roflumilast by affecting CYP1A2 metabolism.
Rufinamide	Decrease concentration of rufinamide thus monitor therapy
Sertraline	Sertraline increases the effect of carbamazepine
Simvastatin	Carbamazepine, a p-glycoprotein inducer, may decrease the effect of simvastatin by increasing its efflux. Monitor for changes in the therapeutic and adverse effects of simvastatin if carbamazepine is initiated, discontinued or dose changed.
Sunitinib	Possible decrease in sunitinib levels
Tacrolimus	Carbamazepine may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Carbamazepine therapy is initiated, discontinued or altered.
Telithromycin	Co-administration may cause decreased Telithromycin and increased Carbemazepine plasma concentrations. Consider alternate therapy.
Temsirolimus	Carbamazepine may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Theophylline	Carbamazepine may decrease the serum concentration of theophylline. Theophylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Ticlopidine	Ticlopidine increases the effect of carbamazepine
Tipranavir	Concomitant use may result in decreased Tipranavir and increased Carbamazepine concentrations.
Tolvaptan	Carbamazepine is a CYP3A4 inducer and will decrease serum concentrations of tolvaptan and ultimately, its clinical effects.
Topiramate	Carbamazepine may decrease the effectiveness of Topiramate by increase its clearance. Monitor for changes in the therapeutic and adverse effects of Topiramate if Carbamazepine is initiated, discontinued or dose changed. Adverse effects related to CNS depression have also been observed during concomitant therapy.
Tramadol	Carbamazepine may decrease the effect of tramadol by increasing Tramadol metabolism and clearance.
Trazodone	The CYP3A4 inducer, Carbamazepine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Carbamazepine is initiated, discontinued or dose changed.
Tretinoin	The strong CYP2C8 inducer, Carbamazepine, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Carbamazepine is initiated, discontinued or dose changed.
Triprolidine	The CNS depressants, Triprolidine and Carbamazepine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Troleandomycin	The macrolide, troleandomycin, may increase the effect of carbamazepine.
Tubocurarine	Decreases the effect of muscle relaxant
Ulipristal	Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.
Valproic Acid	Decreases the effect of valproic acid
Vandetanib	Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vecuronium	Decreases the effect of muscle relaxant
Vemurafenib	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Verapamil	Verapamil may increase the serum concentration of Carbamazepine by decreasing its metabolism. Monitor for changes in the therapeutic/adverse effects of Carbamazepine if Verapamil is initiated, discontinued or dose changed.
Vilazodone	Carbamazepine may increase the metabolism of Selective Serotonin Reuptake Inhibitors (SSRI). Specifically those agents metabolized via CYP1A2, 2C, and/or 3A4 isoenzymes. Selective Serotonin Reuptake Inhibitors may decrease the metabolism of Carbamazepine. Specifically those SSRIs that inhibit CYP3A4 isoenzymes.
Voriconazole	Carbamazepine may reduce serum concentrations and efficacy of voriconazole likely by increasing its metabolism. Concomitant voriconazole and carbamazepine therapy is contraindicated.
Warfarin	Carbamazepine may decrease the anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic and adverse effects of warfarin if carbamazepine is initiated, discontinued or dose changed.
Ziprasidone	Increases the effect and toxicity of ziprasidone

Food Interactions

Avoid taking grapefruit or grapefruit juice throughout treatment.
Grapefruit can significantly increase serum levels of this product.
Take with food, increases availability and reduces irritation.
Avoid alcohol.

Sodium channel protein type 5 subunit alpha
Name	Sodium channel protein type 5 subunit alpha
Gene Name	SCN5A
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Yang YC, Huang CS, Kuo CC: Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal na+ channels. Anesthesiology. 2010 Jul;113(1):160-74. - Pubmed Yang YC, Kuo CC: Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker. Mol Pharmacol. 2002 Nov;62(5):1228-37. - Pubmed Lipkind GM, Fozzard HA: Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol Pharmacol. 2010 Oct;78(4):631-8. Epub 2010 Jul 19. - Pubmed
DTHybrid score	0.508

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. - Pubmed Levy RH: Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia. 1995;36 Suppl 5:S8-13. - Pubmed Cazali N, Tran A, Treluyer JM, Rey E, d'Athis P, Vincent J, Pons G: Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human. Br J Clin Pharmacol. 2003 Nov;56(5):526-36. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9118
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inducer
References	Cazali N, Tran A, Treluyer JM, Rey E, d'Athis P, Vincent J, Pons G: Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human. Br J Clin Pharmacol. 2003 Nov;56(5):526-36. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4944
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor,inducer
References	Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5488
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6614
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5757
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4186
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5259
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4055
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Kim KA, Oh SO, Park PW, Park JY: Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects. Eur J Clin Pharmacol. 2005 Jun;61(4):275-80. Epub 2005 May 25. - Pubmed
DTHybrid score	0.203

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed Owen A, Pirmohamed M, Tettey JN, Morgan P, Chadwick D, Park BK: Carbamazepine is not a substrate for P-glycoprotein. Br J Clin Pharmacol. 2001 Apr;51(4):345-9. - Pubmed Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.5801
RalA-binding protein 1
Name	RalA-binding protein 1
Gene Name	Not Available
Actions	substrate
References	Awasthi S, Hallene KL, Fazio V, Singhal SS, Cucullo L, Awasthi YC, Dini G, Janigro D: RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci. 2005 Sep 27;6:61. - Pubmed
DTHybrid score	Not Available
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Hasler R, Faltraco F, Remmler C, von Spiczak S, Kroemer HK, Runge U, Boor R, Stephani U, Cascorbi I: Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet Genomics. 2009 May;19(5):353-62. - Pubmed
DTHybrid score	0.2636

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.4956
6013	Cytochrome P450 2E1	CYP2E1	0.2153
587	Serum albumin	ALB	0.1784
6024	Cytochrome P450 1A1	CYP1A1	0.1777
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.175
5718	Cytochrome P450 2A6	CYP2A6	0.1491
20	Prostaglandin G/H synthase 1	PTGS1	0.1417
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1379
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1236
862	Multidrug resistance-associated protein 1	ABCC1	0.1175
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1117
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1071
6106	Cytochrome P450 2C18	CYP2C18	0.1036
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0953
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.09
1729	Solute carrier family 22 member 6	SLC22A6	0.0889
290	Prostaglandin G/H synthase 2	PTGS2	0.0824
6145	Solute carrier family 22 member 1	SLC22A1	0.0808
492	Histamine H1 receptor	HRH1	0.0782
776	Bile salt export pump	ABCB11	0.0773
824	Sodium-dependent serotonin transporter	SLC6A4	0.0765
6144	Solute carrier family 22 member 2	SLC22A2	0.074
2164	Multidrug resistance-associated protein 4	ABCC4	0.0697
3811	Cytochrome P450 19A1	CYP19A1	0.0686
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0673
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0656
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0655
1898	Cytochrome P450 1B1	CYP1B1	0.0654
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0605
847	Mu-type opioid receptor	OPRM1	0.0595
118	Organic cation/carnitine transporter 2	SLC22A5	0.0574
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0562
556	Alpha-1A adrenergic receptor	ADRA1A	0.0562
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0556
6142	Solute carrier family 22 member 8	SLC22A8	0.0546
831	D(2) dopamine receptor	DRD2	0.0539
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0538
136	Estrogen receptor	ESR1	0.0538
817	DNA topoisomerase 2-alpha	TOP2A	0.0523
465	Calmodulin	CALM1	0.0515
6143	Solute carrier family 22 member 7	SLC22A7	0.0506
467	Delta-type opioid receptor	OPRD1	0.0484
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0478
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0478
731	HIV-1 protease	HIV-1 protease	0.0476
6031	Cytochrome P450 3A43	CYP3A43	0.0468
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0461
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0461
696	Kappa-type opioid receptor	OPRK1	0.0461
871	Glucocorticoid receptor	NR3C1	0.046
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0456
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0429
260	Cytochrome P450 51	ERG11	0.0422
761	Cytochrome P450 51	ERG11	0.0422
3163	Cytochrome P450 51	cyp51	0.0422
318	Alpha-2A adrenergic receptor	ADRA2A	0.0419
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0415
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0404
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.04
713	Sodium-dependent dopamine transporter	SLC6A3	0.04
632	Alpha-1B adrenergic receptor	ADRA1B	0.0395
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0394
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0394
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0394
3923	Cholinesterase	BCHE	0.0391
70	Type-1 angiotensin II receptor	AGTR1	0.0386
6148	Multidrug resistance-associated protein 7	ABCC10	0.038
6147	Solute carrier family 22 member 3	SLC22A3	0.037
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0369
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0366
468	Cytochrome P450 4A11	CYP4A11	0.0362
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.036
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0359
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0356
4604	Liver carboxylesterase 1	CES1	0.0354
3941	Amine oxidase [flavin-containing] A	MAOA	0.035
477	DNA topoisomerase 4 subunit A	parC	0.035
886	DNA topoisomerase 4 subunit A	parC	0.035
6226	DNA topoisomerase 4 subunit A	parC	0.035
23	D(1A) dopamine receptor	DRD1	0.0346
404	DNA gyrase subunit A	gyrA	0.0344
6224	DNA gyrase subunit A	gyrA	0.0344
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0343
833	Organic cation/carnitine transporter 1	SLC22A4	0.0342
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0341
6141	Sodium/bile acid cotransporter	SLC10A1	0.0333
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0333
766	Beta-2 adrenergic receptor	ADRB2	0.0329
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0325
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0322
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0319
1024	Solute carrier family 22 member 11	SLC22A11	0.0318
614	Progesterone receptor	PGR	0.0317
6182	Cytochrome P450 2J2	CYP2J2	0.0312
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0311
6220	Aryl hydrocarbon receptor	AHR	0.031
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0307
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.03
122	P2Y purinoceptor 12	P2RY12	0.0299
6137	Multidrug resistance-associated protein 6	ABCC6	0.0298
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0298
789	Alpha-1D adrenergic receptor	ADRA1D	0.0294
6136	Multidrug resistance-associated protein 5	ABCC5	0.029
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0288
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0286
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0286
638	D(3) dopamine receptor	DRD3	0.0286
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0282
193	Beta-1 adrenergic receptor	ADRB1	0.0277
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0275
3939	Amine oxidase [flavin-containing] B	MAOB	0.0269
146	Androgen receptor	AR	0.0266
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0266
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0265
36	Insulin receptor	INSR	0.0258
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0253
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0253
844	Epidermal growth factor receptor	EGFR	0.0252
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0251
504	Mast/stem cell growth factor receptor	KIT	0.0249
811	Translocator protein	TSPO	0.0247
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0243
737	Mineralocorticoid receptor	NR3C2	0.0239
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0238
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0235
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0235
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0229
4120	NADPH--cytochrome P450 reductase	POR	0.0224
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0223
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0221
26	Vascular endothelial growth factor receptor 3	FLT4	0.0216
756	Sex hormone-binding globulin	SHBG	0.0214
629	Alpha-2B adrenergic receptor	ADRA2B	0.0212
777	Tumor necrosis factor	TNF	0.0209
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0207
32	Vascular endothelial growth factor receptor 1	FLT1	0.0206
407	Vascular endothelial growth factor receptor 2	KDR	0.0205
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0202
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0198
818	50S ribosomal protein L10	rplJ	0.0198
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0197
172	Potassium channel subfamily K member 1	KCNK1	0.0196
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0196
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0195
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0195
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0195
29	Tubulin beta-1 chain	TUBB1	0.0193
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0191
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0189
378	Alpha-2C adrenergic receptor	ADRA2C	0.0188
891	Dihydropteroate synthase	folP	0.0188
5359	Dihydropteroate synthase	folP	0.0188
7175	Dihydropteroate synthase	sulI	0.0188
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0186
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0185
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0185
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0185
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0185
921	Glutamate receptor 2	GRIA2	0.0183
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0183
33	Cystine/glutamate transporter	SLC7A11	0.0183
869	Estrogen receptor beta	ESR2	0.0183
723	Cytosolic phospholipase A2	PLA2G4A	0.0182
161	Tubulin beta chain	TUBB	0.0182
312	Tubulin beta chain	TUB2	0.0182
380	Cytochrome P450 17A1	CYP17A1	0.0179
6138	Multidrug resistance protein 3	ABCB4	0.0179
124	Histamine H2 receptor	HRH2	0.0174
275	Arachidonate 5-lipoxygenase	ALOX5	0.0174
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0174
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0172
1757	Myeloperoxidase	MPO	0.0172
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0172
3233	Bile acid receptor	NR1H4	0.0171
427	Substance-P receptor	TACR1	0.017
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0169
738	Monocarboxylate transporter 1	SLC16A1	0.0167
1010	Cytochrome P450 51A1	CYP51A1	0.0167
273	Apoptosis regulator Bcl-2	BCL2	0.0166
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0165
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0165
432	D(4) dopamine receptor	DRD4	0.0165
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0164
952	Dipeptidyl peptidase 4	DPP4	0.0158
1656	CYP2B protein	CYP2B	0.0157
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0155
6085	Fatty acid-binding protein, intestinal	FABP2	0.0154
232	Corticosteroid-binding globulin	SERPINA6	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
6020	Aldehyde oxidase	AOX1	0.0154
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0153
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0152
716	5-hydroxytryptamine 7 receptor	HTR7	0.015
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0148
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0147
94	5-hydroxytryptamine 4 receptor	HTR4	0.0147
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0146
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0144
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0144
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.014
3947	Xanthine dehydrogenase/oxidase	XDH	0.014
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.014
6102	Arylamine N-acetyltransferase 2	NAT2	0.0139
4122	Histone deacetylase 2	HDAC2	0.0139
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0135
24	Thymidylate synthase	TMP1	0.0135
359	Thymidylate synthase	TYMS	0.0135
2626	Thymidylate synthase	thyA	0.0135
2729	Thymidylate synthase	thyA	0.0135
5352	Thymidylate synthase	THYA	0.0135
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0135
1630	Integrin beta-2	ITGB2	0.0134
2539	Tubulin alpha-1 chain	TUBA4A	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
2808	Chloramphenicol acetyltransferase 3	cat3	0.013
165	FL cytokine receptor	FLT3	0.0129
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0129
6014	Cytochrome P450 2A13	CYP2A13	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
1192	Sulfotransferase 1A1	SULT1A1	0.0128
54	Prothrombin	F2	0.0127
6044	Serum paraoxonase/lactonase 3	PON3	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0126
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0125
16	Adenosine A1 receptor	ADORA1	0.0125
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0124
373	Transthyretin	TTR	0.0123
174	Sigma 1-type opioid receptor	SIGMAR1	0.0123
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
1852	Microtubule-associated protein 2	MAP2	0.0122
117	Sterol O-acyltransferase 1	SOAT1	0.0121
1178	Adenosine A2a receptor	ADORA2A	0.012
705	Glutamate receptor 1	GRIA1	0.0119
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0119
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0119
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0118
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0118
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0118
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0118
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
365	Dihydrofolate reductase	DHFR	0.0115
2381	Dihydrofolate reductase	DFR1	0.0115
2833	Dihydrofolate reductase	Not Available	0.0115
2931	Dihydrofolate reductase	folA	0.0115
3544	Dihydrofolate reductase	folA	0.0115
3682	Dihydrofolate reductase	folA	0.0115
6642	Dihydrofolate reductase	folA	0.0115
6756	Dihydrofolate reductase	dfrA	0.0115
295	Carbonic anhydrase 1	CA1	0.0114
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0114
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0113
904	Glutathione S-transferase P	GSTP1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0108
2443	Azurin	azu	0.0108
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0107
1629	Transcription factor AP-1	JUN	0.0107
4237	50S ribosomal protein L22	rplV	0.0106
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0105
482	Glycine receptor subunit alpha-1	GLRA1	0.0105
5923	Microtubule-associated protein tau	MAPT	0.0104
5924	Microtubule-associated protein 4	MAP4	0.0104
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0104
908	Glutathione S-transferase theta-1	GSTT1	0.0104
1353	DNA topoisomerase 1	TOP1	0.0104
3552	DNA topoisomerase 1	topA	0.0104
592	Carbonic anhydrase 4	CA4	0.0103
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0103
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0102
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
469	Annexin A1	ANXA1	0.01
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.01
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.01
1256	5-hydroxytryptamine 6 receptor	HTR6	0.01
474	Acetylcholinesterase	ACHE	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
6146	High affinity copper uptake protein 1	SLC31A1	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0097
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
49	Endothelin B receptor	EDNRB	0.0096
84	Nuclear receptor 0B1	NR0B1	0.0095
163	D(1B) dopamine receptor	DRD5	0.0095
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0095
459	Retinoic acid receptor RXR-alpha	RXRA	0.0094
4238	50S ribosomal protein L4	rplD	0.0094
5578	50S ribosomal protein L4	rplD	0.0094
6173	50S ribosomal protein L4	rplD	0.0094
6219	50S ribosomal protein L4	rplD	0.0094
319	Opioid receptor, sigma 1	OPRS1	0.0094
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0094
88	Retinoic acid receptor RXR-beta	RXRB	0.0093
1760	Aminopeptidase N	ANPEP	0.0093
6843	Aminopeptidase N	pepN	0.0093
3809	Estrogen-related receptor gamma	ESRRG	0.0093
1618	High affinity nerve growth factor receptor	NTRK1	0.0093
284	DNA-directed RNA polymerase beta chain	rpoB	0.0092
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0092
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0092
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0092
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0092
239	Coagulation factor X	F10	0.0091
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0091
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0091
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0091
572	Integrin alpha-L	ITGAL	0.0091
357	Carbonic anhydrase 2	CA2	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
823	Fibroblast growth factor receptor 2	FGFR2	0.009
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.009
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
2449	Tubulin alpha-3 chain	TUBA1A	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
3810	Catechol O-methyltransferase	COMT	0.0086
131	Synaptic vesicular amine transporter	SLC18A2	0.0086
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0085
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0085
6043	Putative G-protein coupled receptor 44	GPR44	0.0085
814	Ryanodine receptor 1	RYR1	0.0084
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0084
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0083
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0082
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0081
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.008
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.008
751	Potassium channel subfamily K member 6	KCNK6	0.008
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.008
1196	Complement decay-accelerating factor	CD55	0.008
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0079
267	Plasminogen activator inhibitor 1	SERPINE1	0.0079
3932	Glutathione S-transferase A2	GSTA2	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1050	Bile salt sulfotransferase	SULT2A1	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
4203	Histamine N-methyltransferase	HNMT	0.0077
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0076
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0076
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0076
4192	DNA topoisomerase 2-beta	TOP2B	0.0075
558	Solute carrier family 12 member 1	SLC12A1	0.0075
1517	Beta-3 adrenergic receptor	ADRB3	0.0074
1541	Metalloproteinase	mmp20	0.0074
4217	Telomerase reverse transcriptase	TERT	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0072
6221	Steroid hormone receptor ERR1	ESRRA	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
511	5-hydroxytryptamine 1F receptor	HTR1F	0.007
6432	Transporter	snf	0.007
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0069
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0069
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0068
4773	Deoxycytidine kinase	DCK	0.0068
4311	tRNA	TRDMT1	0.0068
4325	tRNA	trmD	0.0068
4328	tRNA	trmD	0.0068
244	Angiotensin-converting enzyme	ACE	0.0068
162	Retinoic acid receptor gamma-1	RARG	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0068
6126	Carbonic anhydrase 7	CA7	0.0067
1483	Membrane copper amine oxidase	AOC3	0.0067
976	Platelet glycoprotein IX	GP9	0.0067
183	Vascular endothelial growth factor A	VEGFA	0.0067
6163	Copper-transporting ATPase 2	ATP7B	0.0067
6165	Copper-transporting ATPase 1	ATP7A	0.0067
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0067
896	Glutathione S-transferase Mu 1	GSTM1	0.0067
1039	Histone deacetylase 9	HDAC9	0.0066
5626	Nucleoside diphosphate kinase B	NME2	0.0066
6149	Solute carrier family 22 member 10	SLC22A10	0.0066
856	Vitamin D3 receptor	VDR	0.0066
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0065
7	Nitric oxide synthase, inducible	NOS2	0.0065
2499	Tubulin beta-2C chain	TUBB2C	0.0065
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
3270	Elongation factor G	fusA	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
153	Dopamine beta-hydroxylase	DBH	0.0062
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
518	Peroxidase/catalase T	katG	0.0061
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0061
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0061
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0061
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0061
3868	Calcineurin subunit B isoform 2	PPP3R2	0.006
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.006
4103	Proteasome subunit beta type 2	PSMB2	0.006
4102	Proteasome subunit beta type 5	PSMB5	0.006
4101	Proteasome subunit beta type 1	PSMB1	0.006
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
563	Thyroid peroxidase	TPO	0.0058
2021	Thrombomodulin	THBD	0.0058
581	Cytochrome P450 2R1	CYP2R1	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0058
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0058
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0058
2320	Thymidine kinase, cytosolic	TK1	0.0057
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0057
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0057
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0055
1275	Estrogen sulfotransferase	SULT1E1	0.0055
5787	Angiopoietin-1 receptor	TEK	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0054
3856	Fibroblast growth factor receptor 3	FGFR3	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
5294	Nucleoside diphosphate kinase A	NME1	0.0054
3086	Plasmepsin-2	Not Available	0.0053
5934	Cytochrome P450 26A1	CYP26A1	0.0053
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0052
936	Ephrin type-A receptor 2	EPHA2	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0051
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0051
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0051
634	Squalene monooxygenase	SQLE	0.005
7196	Squalene monooxygenase	ERG1	0.005
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.005
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0049
719	Retinoic acid receptor responder protein 1	RARRES1	0.0049
1123	Eosinophil cationic protein	RNASE3	0.0049
770	Retinoic acid-induced protein 3	GPRC5A	0.0049
6042	Prostaglandin reductase 2	PTGR2	0.0048
1650	Heme carrier protein 1	SLC46A1	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0047
6167	Organic solute transporter subunit beta	OSTB	0.0047
6166	Organic solute transporter subunit alpha	OSTA	0.0047
714	Glutathione reductase, mitochondrial	GSR	0.0047
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0047
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0047
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0046
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0046
173	Toll-like receptor 7	TLR7	0.0046
1992	Vitamin D-binding protein	GC	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0045
489	Monocarboxylate transporter 2	SLC16A7	0.0044
2599	Tyrosine-protein kinase HCK	HCK	0.0044
1714	Mitogen-activated protein kinase 3	MAPK3	0.0044
6048	Troponin C, skeletal muscle	TNNC2	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
3957	Adenosine deaminase	ADA	0.0044
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
569	Retinal dehydrogenase 2	ALDH1A2	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
1864	RET proto-oncogene	RET	0.0042
1313	Lactoylglutathione lyase	GLO1	0.0042
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0042
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0042
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0042
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
3917	Methylenetetrahydrofolate reductase	MTHFR	0.004
6824	Tyrosine-protein kinase Lyn	LYN	0.004
730	Retinoic acid receptor alpha	RARA	0.004
611	Retinal dehydrogenase 1	ALDH1A1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
1792	Tissue-type plasminogen activator	PLAT	0.004
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0038
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0038
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0038
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0038
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0038
85	Growth hormone receptor	GHR	0.0038
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
6211	Tubulin epsilon chain	TUBE1	0.0037
6210	Tubulin delta chain	TUBD1	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
6212	Tubulin gamma-1 chain	TUBG1	0.0037
5798	Mitogen-activated protein kinase 11	MAPK11	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0037
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0036
6218	Pannexin-1	PANX1	0.0036
251	Alcohol dehydrogenase 1A	ADH1A	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0036
6837	Serine/threonine-protein kinase 17B	STK17B	0.0036
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0036
517	Alcohol dehydrogenase 1C	ADH1C	0.0035
444	Alcohol dehydrogenase 1B	ADH1B	0.0035
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0035
939	50S ribosomal protein L3	rplC	0.0035
758	Thyroid hormone receptor alpha	THRA	0.0034
3937	Fatty-acid amide hydrolase	FAAH	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0034
820	Glycine receptor subunit alpha-2	GLRA2	0.0034
484	Tyrosine-protein kinase ABL2	ABL2	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
291	Nitric-oxide synthase, endothelial	NOS3	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
6131	Carbonic anhydrase 14	CA14	0.0032
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0032
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0032
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0032
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0032
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0032
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0031
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0031
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0031
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0031
702	UMP-CMP kinase	CMPK1	0.0031
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
164	Histamine H4 receptor	HRH4	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
6134	Sodium channel subunit beta-3	SCN3B	0.0031
6135	Sodium channel subunit beta-4	SCN4B	0.003
6132	Sodium channel subunit beta-1	SCN1B	0.003
6133	Sodium channel subunit beta-2	SCN2B	0.003
3639	Thymidine phosphorylase	deoA	0.003
3936	Thymidine phosphorylase	TYMP	0.003
6127	Carbonic anhydrase-related protein	CA8	0.003
6129	Carbonic anhydrase-related protein 11	CA11	0.003
6128	Carbonic anhydrase-related protein 10	CA10	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
6122	Carbonic anhydrase 3	CA3	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
2216	Fibroblast growth factor receptor 4	FGFR4	0.0029
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0029
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0029
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
1291	cAMP response element-binding protein	CREB1	0.0028
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0028
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0028
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3587	Gastrotropin	FABP6	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6130	Carbonic anhydrase 13	CA13	0.0026
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0026
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
6859	Protein S100-A4	S100A4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
3830	Calreticulin	CALR	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0025
1374	Natriuretic peptides B	NPPB	0.0025
1827	Gap junction alpha-1 protein	GJA1	0.0025
1908	Vascular cell adhesion protein 1	VCAM1	0.0025
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
2207	Rhodopsin	RHO	0.0024
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0024
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0024
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0024
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0024
6168	Solute carrier family 22 member 16	SLC22A16	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
268	Adenosine A2b receptor	ADORA2B	0.0024
65	Matrix metalloproteinase-9	Not Available	0.0023
4226	Uridine phosphorylase 2	UPP2	0.0023
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0023
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0023
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3007	Carbonic anhydrase 12	CA12	0.0022
4205	Carbonic anhydrase 9	CA9	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
4225	Uridine phosphorylase 1	UPP1	0.0021
2091	Endoplasmin	HSP90B1	0.0021
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6459	Glycodelin	PAEP	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
413	Amidophosphoribosyltransferase	PPAT	0.002
2515	Amidophosphoribosyltransferase	purF	0.002
3714	Amidophosphoribosyltransferase	purF	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
760	Fibroblast growth factor 1	FGF1	0.0019
76	Nitric-oxide synthase, brain	NOS1	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
1253	Interferon gamma	IFNG	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0017
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0017
1268	Neuropeptide S receptor	NPSR1	0.0017
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0017
4041	Microsomal glutathione S-transferase 2	MGST2	0.0016
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
5818	Folate receptor alpha	FOLR1	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
6677	Myelin P2 protein	PMP2	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
3221	Cytochrome c4	cc4	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
293	Gamma-glutamyl hydrolase	GGH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
292	Activin receptor type-1	ACVR1	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6501	Fatty acid-binding protein, liver	FABP1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
2298	Cytochrome P450-cam	camC	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6500	Phospholipase A2	PLA2G1B	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
125	DNA polymerase beta	POLB	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
4920	Peroxidase/catalase	katG	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
798	Osteocalcin	BGLAP	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00564 - Carbamazepine

Targets

Enzymes

Transporters

Predictions