DT-Web: DB00949

Identification

Name

Felbamate

Accession Number

DB00949 (APRD00505)

Type

small molecule

Description

Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

238.2399

Groups

approved

Monoisotopic Weight

238.095356946

Pharmacology

Indication

For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use.

Mechanism of action

The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal test systems designed to detect anticonvulsant activity, felbamate has properties in common with other marketed anticonvulsants. In vitro receptor binding studies suggest that felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex. Antagonism of the NMDA receptor glycine binding site may block the effects of the excitatory amino acids and suppress seizure activity. Animal studies indicate that felbamate may increase the seizure threshold and may decrease seizure spread. It is also indicated that felbamate has weak inhibitory effects on GABA-receptor binding, benzodiazepine receptor binding.

Absorption

>90%

Protein binding

20-36%

Biotransformation

Hepatic

Route of elimination

Not Available

Toxicity

LD₅₀=5000 mg/kg (Orally in rats)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Carbamazepine	Decreased effect of both products
Ethotoin	Increased phenytoin levels and decreased felbamate levels
Fosphenytoin	Increased phenytoin levels and decreased felbamate levels
Mephenytoin	Increased phenytoin levels and decreased felbamate levels
Phenobarbital	Felbamate increases the effect and toxicity of phenobarbital/primidone
Phenytoin	Increased phenytoin levels and decreased felbamate levels
Primidone	Felbamate may increase the effect and toxicity of primidone.
Quinupristin	This combination presents an increased risk of toxicity
Telithromycin	Telithromycin may reduce clearance of Felbamate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Felbamate if Telithromycin is initiated, discontinued or dose changed.
Triprolidine	The CNS depressants, Triprolidine and Felbamate, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Ulipristal	Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.
Valproic Acid	Felbamate, a CYP2C19 inhibitor, may decrease the metabolism of Valproic acid, a CYP2C19 substrate. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Felbamate is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of felbamate by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of felbamate if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Taking it after a meal may reduce the incidence of adverse effects.

Glutamate [NMDA] receptor subunit epsilon-2
Name	Glutamate [NMDA] receptor subunit epsilon-2
Gene Name	GRIN2B
Pharmacological action	yes
Actions	antagonist
References	Kleckner NW, Glazewski JC, Chen CC, Moscrip TD: Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action. J Pharmacol Exp Ther. 1999 May;289(2):886-94. - Pubmed Harty TP, Rogawski MA: Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Chang HR, Kuo CC: Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor. J Med Chem. 2008 Mar 27;51(6):1534-45. Epub 2008 Feb 27. - Pubmed Luszczki JJ, Danysz W, Czuczwar SJ: Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model. Pharmacology. 2008;81(3):259-65. Epub 2008 Feb 4. - Pubmed
DTHybrid score	0.2803
Glutamate [NMDA] receptor subunit 3A
Name	Glutamate [NMDA] receptor subunit 3A
Gene Name	GRIN3A
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.3538
Glutamate [NMDA] receptor subunit epsilon-1
Name	Glutamate [NMDA] receptor subunit epsilon-1
Gene Name	GRIN2A
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.2658

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4375
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Williams DA, Foye WO, Lemke TL. Foye’s principles of medicinal chemistry. Lippincott Williams & Wilkins; 2002. - Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3299
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2696

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.1916
4119	Cytochrome P450 2D6	CYP2D6	0.1799
6030	Cytochrome P450 2B6	CYP2B6	0.168
4200	Cytochrome P450 1A2	CYP1A2	0.1429
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.1291
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.1231
1588	Multidrug resistance protein 1	ABCB1	0.1222
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.118
4924	Cytochrome P450 2C8	CYP2C8	0.115
4118	Cytochrome P450 3A5	CYP3A5	0.1087
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0959
5718	Cytochrome P450 2A6	CYP2A6	0.0932
6107	Cytochrome P450 3A7	CYP3A7	0.0793
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0694
6024	Cytochrome P450 1A1	CYP1A1	0.065
587	Serum albumin	ALB	0.0607
831	D(2) dopamine receptor	DRD2	0.0586
6144	Solute carrier family 22 member 2	SLC22A2	0.0515
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0438
20	Prostaglandin G/H synthase 1	PTGS1	0.0417
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0413
3923	Cholinesterase	BCHE	0.0358
174	Sigma 1-type opioid receptor	SIGMAR1	0.0354
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0343
824	Sodium-dependent serotonin transporter	SLC6A4	0.0341
492	Histamine H1 receptor	HRH1	0.034
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0337
696	Kappa-type opioid receptor	OPRK1	0.0335
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0333
3811	Cytochrome P450 19A1	CYP19A1	0.0332
713	Sodium-dependent dopamine transporter	SLC6A3	0.0312
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0312
6106	Cytochrome P450 2C18	CYP2C18	0.0307
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0301
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0267
482	Glycine receptor subunit alpha-1	GLRA1	0.0258
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0257
260	Cytochrome P450 51	ERG11	0.0249
761	Cytochrome P450 51	ERG11	0.0249
3163	Cytochrome P450 51	cyp51	0.0249
6145	Solute carrier family 22 member 1	SLC22A1	0.0222
23	D(1A) dopamine receptor	DRD1	0.0219
916	Metabotropic glutamate receptor 1	GRM1	0.0213
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0212
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.021
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.021
1729	Solute carrier family 22 member 6	SLC22A6	0.0207
556	Alpha-1A adrenergic receptor	ADRA1A	0.0201
2178	Metabotropic glutamate receptor 5	GRM5	0.0201
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0201
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0196
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0193
290	Prostaglandin G/H synthase 2	PTGS2	0.0188
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0188
862	Multidrug resistance-associated protein 1	ABCC1	0.0188
847	Mu-type opioid receptor	OPRM1	0.0187
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0187
871	Glucocorticoid receptor	NR3C1	0.018
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0178
1898	Cytochrome P450 1B1	CYP1B1	0.0177
468	Cytochrome P450 4A11	CYP4A11	0.0176
4096	Metabotropic glutamate receptor 3	GRM3	0.0174
1362	Metabotropic glutamate receptor 2	GRM2	0.0174
467	Delta-type opioid receptor	OPRD1	0.0174
638	D(3) dopamine receptor	DRD3	0.0172
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0172
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0168
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0166
731	HIV-1 protease	HIV-1 protease	0.0165
3939	Amine oxidase [flavin-containing] B	MAOB	0.0165
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0164
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0163
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0163
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0163
136	Estrogen receptor	ESR1	0.0158
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0155
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0152
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0152
1268	Neuropeptide S receptor	NPSR1	0.0152
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0152
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0151
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.015
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0145
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0144
776	Bile salt export pump	ABCB11	0.0142
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0141
705	Glutamate receptor 1	GRIA1	0.014
318	Alpha-2A adrenergic receptor	ADRA2A	0.0139
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0135
6073	Potassium channel subfamily K member 9	KCNK9	0.0133
6072	Potassium channel subfamily K member 3	KCNK3	0.0133
427	Substance-P receptor	TACR1	0.0131
632	Alpha-1B adrenergic receptor	ADRA1B	0.0129
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0128
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0128
6031	Cytochrome P450 3A43	CYP3A43	0.0126
3941	Amine oxidase [flavin-containing] A	MAOA	0.0126
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0123
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0122
694	Matrix protein 2	M	0.0121
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0121
820	Glycine receptor subunit alpha-2	GLRA2	0.012
450	Muscarinic acetylcholine receptor M4	CHRM4	0.012
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0119
766	Beta-2 adrenergic receptor	ADRB2	0.0118
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0117
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0114
6142	Solute carrier family 22 member 8	SLC22A8	0.0108
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0108
251	Alcohol dehydrogenase 1A	ADH1A	0.0106
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0103
2164	Multidrug resistance-associated protein 4	ABCC4	0.0102
789	Alpha-1D adrenergic receptor	ADRA1D	0.0102
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0102
444	Alcohol dehydrogenase 1B	ADH1B	0.0101
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0099
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0098
2207	Rhodopsin	RHO	0.0095
465	Calmodulin	CALM1	0.0094
921	Glutamate receptor 2	GRIA2	0.0094
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0094
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0094
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0093
319	Opioid receptor, sigma 1	OPRS1	0.0093
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0092
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0092
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0092
118	Organic cation/carnitine transporter 2	SLC22A5	0.0092
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0091
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.009
777	Tumor necrosis factor	TNF	0.009
6143	Solute carrier family 22 member 7	SLC22A7	0.009
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.009
817	DNA topoisomerase 2-alpha	TOP2A	0.0089
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0089
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0089
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0089
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0089
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0089
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0089
122	P2Y purinoceptor 12	P2RY12	0.0089
3904	Alanine aminotransferase 2	GPT2	0.0088
735	Alanine aminotransferase 1	GPT	0.0088
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0088
922	Glutamate receptor 4	GRIA4	0.0087
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0087
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0087
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0087
4018	Glutamate receptor delta-2 subunit	GRID2	0.0087
4027	Glutamate receptor delta-1 subunit	GRID1	0.0087
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0087
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0087
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0087
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0087
4019	Excitatory amino acid transporter 4	SLC1A6	0.0087
4026	Aspartyl aminopeptidase	DNPEP	0.0087
1912	Excitatory amino acid transporter 1	SLC1A3	0.0087
4016	Excitatory amino acid transporter 5	SLC1A7	0.0087
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0087
1047	Excitatory amino acid transporter 2	SLC1A2	0.0087
664	Glutamate decarboxylase 2	GAD2	0.0087
3890	Glutamate decarboxylase 2	GAD2	0.0087
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0087
4020	Glutamyl aminopeptidase	ENPEP	0.0087
927	Metabotropic glutamate receptor 8	GRM8	0.0087
925	Metabotropic glutamate receptor 4	GRM4	0.0087
926	Metabotropic glutamate receptor 7	GRM7	0.0087
4017	5-oxoprolinase	OPLAH	0.0087
6147	Solute carrier family 22 member 3	SLC22A3	0.0086
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0085
16	Adenosine A1 receptor	ADORA1	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0082
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0082
193	Beta-1 adrenergic receptor	ADRB1	0.0081
517	Alcohol dehydrogenase 1C	ADH1C	0.0081
811	Translocator protein	TSPO	0.008
232	Corticosteroid-binding globulin	SERPINA6	0.008
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.008
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.008
146	Androgen receptor	AR	0.0079
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0079
833	Organic cation/carnitine transporter 1	SLC22A4	0.0078
6102	Arylamine N-acetyltransferase 2	NAT2	0.0077
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0076
614	Progesterone receptor	PGR	0.0076
3426	Glutamine synthetase	glnA	0.0075
3987	Glutamine synthetase	GLUL	0.0075
592	Carbonic anhydrase 4	CA4	0.0075
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0074
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0074
6151	Monocarboxylate transporter 10	SLC16A10	0.0074
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0074
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0074
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0074
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0074
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0074
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0074
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0074
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0074
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0074
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0074
625	Glutamate carboxypeptidase 2	FOLH1	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
665	Phosphoserine aminotransferase	PSAT1	0.0073
4652	Phosphoserine aminotransferase	serC	0.0073
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0073
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0073
420	Glutamate decarboxylase 1	GAD1	0.0073
3900	Glutamate decarboxylase 1	GAD1	0.0073
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0073
818	50S ribosomal protein L10	rplJ	0.0071
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0071
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0071
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0071
411	Glycine N-methyltransferase	GNMT	0.0071
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0069
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0068
161	Tubulin beta chain	TUBB	0.0068
312	Tubulin beta chain	TUB2	0.0068
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0068
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0068
4057	Glycine N-acyltransferase	GLYAT	0.0068
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0068
4056	N-arachidonyl glycine receptor	GPR18	0.0068
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0068
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0068
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0068
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0068
1466	Glycyl-tRNA synthetase	GARS	0.0068
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0068
629	Alpha-2B adrenergic receptor	ADRA2B	0.0068
1010	Cytochrome P450 51A1	CYP51A1	0.0068
6182	Cytochrome P450 2J2	CYP2J2	0.0068
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0067
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0067
378	Alpha-2C adrenergic receptor	ADRA2C	0.0067
3877	Growth-inhibiting protein 18	GIG18	0.0067
1671	Excitatory amino acid transporter 3	SLC1A1	0.0067
6220	Aryl hydrocarbon receptor	AHR	0.0067
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0067
923	Glutamate receptor 3	GRIA3	0.0066
33	Cystine/glutamate transporter	SLC7A11	0.0066
763	Tyrosine aminotransferase	TAT	0.0066
5493	Tyrosine aminotransferase	Not Available	0.0066
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0065
4604	Liver carboxylesterase 1	CES1	0.0065
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0064
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0064
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0064
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0064
124	Histamine H2 receptor	HRH2	0.0064
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0064
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0063
432	D(4) dopamine receptor	DRD4	0.0063
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0063
6014	Cytochrome P450 2A13	CYP2A13	0.0062
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0061
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.006
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.006
1178	Adenosine A2a receptor	ADORA2A	0.006
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.006
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0059
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
1024	Solute carrier family 22 member 11	SLC22A11	0.0059
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0058
738	Monocarboxylate transporter 1	SLC16A1	0.0058
6148	Multidrug resistance-associated protein 7	ABCC10	0.0057
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0057
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0057
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0057
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0057
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0057
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0056
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0056
62	Glycine receptor subunit beta	GLRB	0.0056
357	Carbonic anhydrase 2	CA2	0.0056
295	Carbonic anhydrase 1	CA1	0.0056
716	5-hydroxytryptamine 7 receptor	HTR7	0.0055
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
891	Dihydropteroate synthase	folP	0.0054
5359	Dihydropteroate synthase	folP	0.0054
7175	Dihydropteroate synthase	sulI	0.0054
29	Tubulin beta-1 chain	TUBB1	0.0054
3947	Xanthine dehydrogenase/oxidase	XDH	0.0054
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0054
373	Transthyretin	TTR	0.0053
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0052
3884	SHMT2 protein	SHMT2	0.0052
3901	SHMT2 protein	SHMT2	0.0052
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0052
3879	Serine hydroxymethyltransferase 2	Not Available	0.0052
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0052
49	Endothelin B receptor	EDNRB	0.0052
1757	Myeloperoxidase	MPO	0.0052
4122	Histone deacetylase 2	HDAC2	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0051
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0051
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0051
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.005
6126	Carbonic anhydrase 7	CA7	0.005
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.005
207	Glutathione synthetase	GSS	0.005
5269	Glutathione synthetase	gshB	0.005
6137	Multidrug resistance-associated protein 6	ABCC6	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
6136	Multidrug resistance-associated protein 5	ABCC5	0.0048
68	Cannabinoid receptor 1	CNR1	0.0048
6141	Sodium/bile acid cotransporter	SLC10A1	0.0048
94	5-hydroxytryptamine 4 receptor	HTR4	0.0047
383	Glycine amidinotransferase, mitochondrial	GATM	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
756	Sex hormone-binding globulin	SHBG	0.0046
1483	Membrane copper amine oxidase	AOC3	0.0046
1253	Interferon gamma	IFNG	0.0046
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0046
844	Epidermal growth factor receptor	EGFR	0.0046
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0046
814	Ryanodine receptor 1	RYR1	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0045
349	Serine--pyruvate aminotransferase	AGXT	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0045
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
70	Type-1 angiotensin II receptor	AGTR1	0.0044
571	Melatonin receptor type 1A	MTNR1A	0.0044
362	Melatonin receptor type 1B	MTNR1B	0.0044
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
2230	Catalase	CAT	0.0043
3249	Catalase	katA	0.0043
3625	Catalase	katA	0.0043
4539	Catalase	katA	0.0043
4941	Catalase	katB	0.0043
153	Dopamine beta-hydroxylase	DBH	0.0043
952	Dipeptidyl peptidase 4	DPP4	0.0043
6020	Aldehyde oxidase	AOX1	0.0043
869	Estrogen receptor beta	ESR2	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0042
183	Vascular endothelial growth factor A	VEGFA	0.0042
856	Vitamin D3 receptor	VDR	0.0042
407	Vascular endothelial growth factor receptor 2	KDR	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0041
26	Vascular endothelial growth factor receptor 3	FLT4	0.004
518	Peroxidase/catalase T	katG	0.004
1656	CYP2B protein	CYP2B	0.004
284	DNA-directed RNA polymerase beta chain	rpoB	0.004
5773	DNA-directed RNA polymerase beta chain	rpoB	0.004
380	Cytochrome P450 17A1	CYP17A1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3932	Glutathione S-transferase A2	GSTA2	0.0039
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0038
32	Vascular endothelial growth factor receptor 1	FLT1	0.0038
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0038
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0038
85	Growth hormone receptor	GHR	0.0038
904	Glutathione S-transferase P	GSTP1	0.0038
563	Thyroid peroxidase	TPO	0.0037
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0037
3810	Catechol O-methyltransferase	COMT	0.0037
823	Fibroblast growth factor receptor 2	FGFR2	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
4120	NADPH--cytochrome P450 reductase	POR	0.0037
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
365	Dihydrofolate reductase	DHFR	0.0037
2381	Dihydrofolate reductase	DFR1	0.0037
2833	Dihydrofolate reductase	Not Available	0.0037
2931	Dihydrofolate reductase	folA	0.0037
3544	Dihydrofolate reductase	folA	0.0037
3682	Dihydrofolate reductase	folA	0.0037
6642	Dihydrofolate reductase	folA	0.0037
6756	Dihydrofolate reductase	dfrA	0.0037
163	D(1B) dopamine receptor	DRD5	0.0037
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
6432	Transporter	snf	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0036
3404	Exotoxin A	eta	0.0036
65	Matrix metalloproteinase-9	Not Available	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0035
939	50S ribosomal protein L3	rplC	0.0035
504	Mast/stem cell growth factor receptor	KIT	0.0035
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0035
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
6043	Putative G-protein coupled receptor 44	GPR44	0.0034
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0034
6138	Multidrug resistance protein 3	ABCB4	0.0034
474	Acetylcholinesterase	ACHE	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
3937	Fatty-acid amide hydrolase	FAAH	0.0032
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
3601	Dihydropteroate synthase 1	folP1	0.0031
3807	Dihydropteroate synthase 1	folP1	0.0031
3808	Dihydropteroate synthase 2	folP2	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
228	Beta platelet-derived growth factor receptor	PDGFRB	0.003
3913	Glutamic acid decarboxylase	GAD65	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
4311	tRNA	TRDMT1	0.0028
4325	tRNA	trmD	0.0028
4328	tRNA	trmD	0.0028
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
2298	Cytochrome P450-cam	camC	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
1192	Sulfotransferase 1A1	SULT1A1	0.0027
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0027
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
737	Mineralocorticoid receptor	NR3C2	0.0026
1618	High affinity nerve growth factor receptor	NTRK1	0.0026
634	Squalene monooxygenase	SQLE	0.0026
7196	Squalene monooxygenase	ERG1	0.0026
1050	Bile salt sulfotransferase	SULT2A1	0.0026
976	Platelet glycoprotein IX	GP9	0.0026
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
239	Coagulation factor X	F10	0.0025
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0025
581	Cytochrome P450 2R1	CYP2R1	0.0024
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0024
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0024
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3809	Estrogen-related receptor gamma	ESRRG	0.0023
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0023
275	Arachidonate 5-lipoxygenase	ALOX5	0.0023
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0023
358	Cystathionine beta-synthase	CBS	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0022
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
6146	High affinity copper uptake protein 1	SLC31A1	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0021
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
908	Glutathione S-transferase theta-1	GSTT1	0.002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.002
106	Cannabinoid receptor 2	CNR2	0.002
7	Nitric oxide synthase, inducible	NOS2	0.0019
6174	50S ribosomal protein L32	rpmF	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
558	Solute carrier family 12 member 1	SLC12A1	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
469	Annexin A1	ANXA1	0.0018
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0018
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0018
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0018
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
683	Potassium transporter	GK0582	0.0018
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0018
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0018
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0018
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0018
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0018
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0018
84	Nuclear receptor 0B1	NR0B1	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
1517	Beta-3 adrenergic receptor	ADRB3	0.0016
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0016
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0016
5787	Angiopoietin-1 receptor	TEK	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0016
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0015
3233	Bile acid receptor	NR1H4	0.0015
54	Prothrombin	F2	0.0015
896	Glutathione S-transferase Mu 1	GSTM1	0.0015
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0015
164	Histamine H4 receptor	HRH4	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0015
1629	Transcription factor AP-1	JUN	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
1541	Metalloproteinase	mmp20	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0014
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0014
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0014
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0014
165	FL cytokine receptor	FLT3	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
6085	Fatty acid-binding protein, intestinal	FABP2	0.0014
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0013
1992	Vitamin D-binding protein	GC	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0013
1630	Integrin beta-2	ITGB2	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4103	Proteasome subunit beta type 2	PSMB2	0.0012
4102	Proteasome subunit beta type 5	PSMB5	0.0012
4101	Proteasome subunit beta type 1	PSMB1	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
1275	Estrogen sulfotransferase	SULT1E1	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
4217	Telomerase reverse transcriptase	TERT	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0012
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
751	Potassium channel subfamily K member 6	KCNK6	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
273	Apoptosis regulator Bcl-2	BCL2	0.0011
936	Ephrin type-A receptor 2	EPHA2	0.0011
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.001
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
291	Nitric-oxide synthase, endothelial	NOS3	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
6044	Serum paraoxonase/lactonase 3	PON3	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
172	Potassium channel subfamily K member 1	KCNK1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.001
6163	Copper-transporting ATPase 2	ATP7B	0.001
6165	Copper-transporting ATPase 1	ATP7A	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
3868	Calcineurin subunit B isoform 2	PPP3R2	0.001
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.001
572	Integrin alpha-L	ITGAL	0.0009
3957	Adenosine deaminase	ADA	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
3221	Cytochrome c4	cc4	0.0009
5798	Mitogen-activated protein kinase 11	MAPK11	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
2320	Thymidine kinase, cytosolic	TK1	0.0009
267	Plasminogen activator inhibitor 1	SERPINE1	0.0009
3830	Calreticulin	CALR	0.0009
1864	RET proto-oncogene	RET	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0009
6149	Solute carrier family 22 member 10	SLC22A10	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0009
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
798	Osteocalcin	BGLAP	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
6218	Pannexin-1	PANX1	0.0008
6221	Steroid hormone receptor ERR1	ESRRA	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
5934	Cytochrome P450 26A1	CYP26A1	0.0008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6459	Glycodelin	PAEP	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
369	Coagulation factor VII	F7	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0007
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0007
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2802	Endoglucanase G	celCCG	0.0007
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
2021	Thrombomodulin	THBD	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
6042	Prostaglandin reductase 2	PTGR2	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
1792	Tissue-type plasminogen activator	PLAT	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
1313	Lactoylglutathione lyase	GLO1	0.0004
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
162	Retinoic acid receptor gamma-1	RARG	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
76	Nitric-oxide synthase, brain	NOS1	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00949 - Felbamate

Targets

Enzymes

Predictions