Partner ID 186
Name Glutamate--cysteine ligase catalytic subunit
Synonyms 546
Gene name GCLC
General function Involved in glutamate-cysteine ligase activity
Specific function Not Available
Gene sequence + ...

ATGGGGCTGCTGTCCCAGGGCTCGCCGCTGAGCTGGGAGGAAACCAAGCGCCATGCCGACCACGTGCGGCGGCACGGGATCCTCCAGTTCCTGCACATCTACCACGCCGTCAAGGACCGGCACAAGGACGTTCTCAAGTGGGGCGATGAGGTGGAATACATGTTGGTATCTTTTGATCATGAAAATAAAAAAGTCCGGTTGGTCCTGTCTGGGGAGAAAGTTCTTGAAACTCTGCAAGAGAAGGGGGAAAGGACAAACCCAAACCATCCTACCCTTTGGAGACCAGAGTATGGGAGTTACATGATTGAAGGGACACCAGGACAGCCCTACGGAGGAACAATGTCCGAGTTCAATACAGTTGAGGCCAACATGCGAAAACGCCGGAAGGAGGCTACTTCTATATTAGAAGAAAATCAGGCTCTTTGCACAATAACTTCATTTCCCAGATTAGGCTGTCCTGGGTTCACACTGCCCGAGGTCAAACCCAACCCAGTGGAAGGAGGAGCTTCCAAGTCCCTCTTCTTTCCAGATGAAGCAATAAACAAGCACCCTCGCTTCAGTACCTTAACAAGAAATATCCGACATAGGAGAGGAGAAAAGGTTGTCATCAATGTACCAATATTTAAGGACAAGAATACACCATCTCCATTTATAGAAACATTTACTGAGGATGATGAAGCTTCAAGGGCTTCTAAGCCGGATCATATTTACATGGATGCCATGGGATTTGGAATGGGCAATTGCTGTCTCCAGGTGACATTCCAAGCCTGCAGTATATCTGAGGCCAGATACCTTTATGATCAGTTGGCTACTATCTGTCCAATTGTTATGGCTTTGAGTGCTGCATCTCCCTTTTACCGAGGCTATGTGTCAGACATTGATTGTCGCTGGGGAGTGATTTCTGCATCTGTAGATGATAGAACTCGGGAGGAGCGAGGACTGGAGCCATTGAAGAACAATAACTATAGGATCAGTAAATCCCGATATGACTCAATAGACAGCTATTTATCTAAGTGTGGTGAGAAATATAATGACATCGACTTGACGATAGATAAAGAGATCTACGAACAGCTGTTGCAGGAAGGCATTGATCATCTCCTGGCCCAGCATGTTGCTCATCTCTTTATTAGAGACCCACTGACACTGTTTGAAGAGAAAATACACCTGGATGATGCTAATGAGTCTGACCATTTTGAGAATATTCAGTCCACAAATTGGCAGACAATGAGATTTAAGCCCCCTCCTCCAAACTCAGACATTGGATGGAGAGTAGAATTTCGACCCATGGAGGTGCAATTAACAGACTTTGAGAACTCTGCCTATGTGGTGTTTGTGGTACTGCTCACCAGAGTGATCCTTTCCTACAAATTGGATTTTCTCATTCCACTGTCAAAGGTTGATGAGAACATGAAGGTAGCACAGAAAAGAGATGCTGTCTTGCAGGGAATGTTTTATTTCAGGAAAGATATTTGCAAAGGTGGCAATGCAGTGGTGGATGGTTGTGGCAAGGCCCAGAACAGCACGGAGCTCGCTGCAGAGGAGTACACCCTCATGAGCATAGACACCATCATCAATGGGAAGGAAGGTGTGTTTCCTGGACTGATCCCAATTCTGAACTCTTACCTTGAAAACATGGAAGTGGATGTGGACACCAGATGTAGTATTCTGAACTACCTAAAGCTAATTAAGAAGAGAGCATCTGGAGAACTAATGACAGTTGCCAGATGGATGAGGGAGTTTATCGCAAACCATCCTGACTACAAGCAAGACAGTGTCATAACTGATGAAATGAATTATAGCCTTATTTTGAAGTGTAACCAAATTGCAAATGAATTATGTGAATGCCCAGAGTTACTTGGATCAGCATTTAGGAAAGTAAAATATAGTGGAAGTAAAACTGACTCATCCAACTAG

Protein sequence + ...

GLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN

GO Classification
function
acid-amino acid ligase activity
glutamate-cysteine ligase activity
binding
catalytic activity
nucleic acid binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
process
cofactor metabolism
coenzyme metabolism
glutathione metabolism
glutathione biosynthesis
physiological process
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca
Id Name
DB00142 L-Glutamic Acid
DB00151 L-Cysteine
Id Name
DB00163 Vitamin E
Id Name
DB00036 Coagulation factor VIIa
DB00055 Drotrecogin alfa
DB00082 Pegvisomant
DB00089 Capromab
DB00100 Coagulation Factor IX
DB00114 Pyridoxal Phosphate
DB00116 Tetrahydrofolic acid
DB00117 L-Histidine
DB00118 S-Adenosylmethionine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00123 L-Lysine
DB00125 L-Arginine
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00143 Glutathione
DB00144 Phosphatidylserine
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00156 L-Threonine
DB00157 NADH
DB00160 L-Alanine
DB00161 L-Valine
DB00163 Vitamin E
DB00167 L-Isoleucine
DB00170 Menadione
DB00171 Adenosine triphosphate
DB00172 L-Proline
DB00174 L-Asparagine
DB00175 Pravastatin
DB00179 Masoprocol
DB00193 Tramadol
DB00228 Enflurane
DB00230 Pregabalin
DB00233 Aminosalicylic Acid
DB00237 Butabarbital
DB00241 Butalbital
DB00244 Mesalazine
DB00266 Dicumarol
DB00273 Topiramate
DB00279 Liothyronine
DB00291 Chlorambucil
DB00293 Raltitrexed
DB00306 Talbutal
DB00312 Pentobarbital
DB00313 Valproic Acid
DB00333 Methadone
DB00345 Aminohippurate
DB00392 Ethopropazine
DB00415 Ampicillin
DB00418 Secobarbital
DB00454 Meperidine
DB00463 Metharbital
DB00466 Picrotoxin
DB00471 Montelukast
DB00502 Haloperidol
DB00514 Dextromethorphan
DB00515 Cisplatin
DB00526 Oxaliplatin
DB00529 Foscarnet
DB00530 Erlotinib
DB00563 Methotrexate
DB00586 Diclofenac
DB00599 Thiopental
DB00608 Chloroquine
DB00627 Niacin
DB00636 Clofibrate
DB00659 Acamprosate
DB00711 Diethylcarbamazine
DB00721 Procaine
DB00731 Nateglinide
DB00740 Riluzole
DB00744 Zileuton
DB00753 Isoflurane
DB00756 Hexachlorophene
DB00773 Etoposide
DB00780 Phenelzine
DB00783 Estradiol
DB00794 Primidone
DB00795 Sulfasalazine
DB00849 Methylphenobarbital
DB00898 Ethanol
DB00903 Ethacrynic acid
DB00915 Amantadine
DB00936 Salicyclic acid
DB00939 Meclofenamic acid
DB00949 Felbamate
DB00958 Carboplatin
DB00977 Ethinyl Estradiol
DB00993 Azathioprine
DB00996 Gabapentin
DB00997 Doxorubicin
DB01008 Busulfan
DB01014 Balsalazide
DB01017 Minocycline
DB01022 Phytonadione
DB01028 Methoxyflurane
DB01032 Probenecid
DB01043 Memantine
DB01045 Rifampin
DB01080 Vigabatrin
DB01098 Rosuvastatin
DB01119 Diazoxide
DB01125 Anisindione
DB01159 Halothane
DB01161 Chloroprocaine
DB01173 Orphenadrine
DB01174 Phenobarbital
DB01189 Desflurane
DB01212 Ceftriaxone
DB01220 Rifaximin
DB01221 Ketamine
DB01229 Paclitaxel
DB01235 Levodopa
DB01236 Sevoflurane
DB01242 Clomipramine
DB01287 Dihydroergotoxine
DB01346 Quinidine barbiturate
DB01351 Amobarbital
DB01352 Aprobarbital
DB01353 Butethal
DB01354 Heptabarbital
DB01355 Hexobarbital
DB01356 Lithium
DB01440 Gamma Hydroxybutyric Acid
DB01483 Barbital
DB01496 Barbituric acid derivative
DB01520 Tenocyclidine
DB01549 Rolicyclidine
DB01583 Liotrix
DB01664 (S)-Des-Me-Ampa
DB01699 (4e)-4-Aminohex-4-Enoic Acid
DB01738 O-Phosphoethanolamine
DB01746 D-Leucine
DB01762 Acetoacetic Acid
DB01786 D-Alanine
DB01834 (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
DB01892 Hyperforin
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01915 S-Hydroxycysteine
DB01927 Duroquinone
DB01931 Dcka, 5,7-Dichlorokynurenic Acid
DB01942 Formic Acid
DB02057 AMPA
DB02073 Biliverdine Ix Alpha
DB02080 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
DB02142 Pyridoxamine-5'-Phosphate
DB02216 S-Methylcysteine
DB02328 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02347 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid
DB02395 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol
DB02400 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione
DB02468 12-Phenylheme
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
DB02510 '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine
DB02556 D-Phenylalanine
DB02633 Cibacron Blue
DB02635 N-[O-Phosphono-Pyridoxyl]-Isoleucine
DB02684 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine
DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB02818 Iodo-Willardiine
DB02852 Domoic Acid
DB02952 Alpha-Aminoisobutyric Acid
DB02966 Fluoro-Willardiine
DB02999 Quisqualate
DB03003 Glutathione Sulfonic Acid
DB03014 Heme
DB03066 D-Lactic Acid
DB03107 Beta-Alanine
DB03147 Flavin-Adenine Dinucleotide
DB03166 Acetic acid
DB03225 D-Tryptophan
DB03240 (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid
DB03256 5-Formyl-5,6,7,8-Tetrahydrofolate
DB03319 (S)-ATPA
DB03376 '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
DB03382 S-Oxy Cysteine
DB03408 Gamma-Glutamylcysteine
DB03425 2s,4r-4-Methylglutamate
DB03431 Adenosine-5'-Diphosphate
DB03575 Phencyclidine
DB03626 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione
DB03686 S-(P-Nitrobenzyl)Glutathione
DB03759 Dnqx
DB03793 Benzoic Acid
DB03796 Palmitic Acid
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03839 D-Tyrosine
DB03906 2-Phenylheme
DB03928 Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol
DB03929 D-Serine
DB04000 Bromo-Willardiine
DB04074 Alpha-ketoisovalerate
DB04077 Glycerol
DB04090 2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione
DB04129 Willardiine
DB04132 S-Hexylglutathione
DB04137 Guanosine-5'-Triphosphate
DB04152 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid
DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid
DB04216 Quercetin
DB04217 L-2-amino-3-butynoic acid
DB04235 4-Amino Hexanoic Acid
DB04256 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
DB04299 Maleic Acid
DB04319 6-Deoxyglucose
DB04339 Carboxymethylenecysteine
DB04348 Taurocholic Acid
DB04392 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04398 Lactic Acid
DB04466 SR12813
DB04531 Benzylcysteine
DB04552 Niflumic Acid
DB04599 Aniracetam
DB04620 Cycloleucine
DB04798 THIO-ATPA
DB04803 Verdoheme
DB04896 Milnacipran
DB05013 Ingenol Mebutate
DB06262 Droxidopa
DB06813 Pralatrexate
DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
DB06914 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
DB06928 (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID
DB07080 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
DB07385 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE
DB07455 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide
DB07544 N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
DB07598 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE
DB07754 N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid
DB07849 S-NONYL-CYSTEINE
DB08303 (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
DB08304 (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
DB08305 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
DB08370 S-(4-BROMOBENZYL)CYSTEINE
DB08794 Ethyl biscoumacetate
DB08834 Tauroursodeoxycholic acid
DB08838 Agmatine
DB08846 Ellagic Acid
DB08864 Rilpivirine
DB08883 Perampanel