DT-Web: DB00150

Identification

Name

L-Tryptophan

Accession Number

DB00150 (EXPT02064, NUTR00058)

Type

small molecule

Description

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

204.2252

Groups

approved

Monoisotopic Weight

204.089877638

Pharmacology

Indication

Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.

Mechanism of action

A number of important side reactions occur during the catabolism of tryptophan on the pathway to acetoacetate. The first enzyme of the catabolic pathway is an iron porphyrin oxygenase that opens the indole ring. The latter enzyme is highly inducible, its concentration rising almost 10-fold on a diet high in tryptophan. Kynurenine is the first key branch point intermediate in the pathway. Kynurenine undergoes deamniation in a standard transamination reaction yielding kynurenic acid. Kynurenic acid and metabolites have been shown to act as antiexcitotoxics and anticonvulsives. A second side branch reaction produces anthranilic acid plus alanine. Another equivalent of alanine is produced further along the main catabolic pathway, and it is the production of these alanine residues that allows tryptophan to be classified among the glucogenic and ketogenic amino acids. The second important branch point converts kynurenine into 2-amino-3-carboxymuconic semialdehyde, which has two fates. The main flow of carbon elements from this intermediate is to glutarate. An important side reaction in liver is a transamination and several rearrangements to produce limited amounts of nicotinic acid, which leads to production of a small amount of NAD⁺ and NADP⁺.

Absorption

Not Available

Protein binding

Not Available

Biotransformation

Hepatic.

Route of elimination

Not Available

Toxicity

Oral rat LD₅₀: > 16 gm/kg. Investigated as a tumorigen, mutagen, reproductive effector. Symptoms of overdose include agitation, confusion, diarrhea, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, talking or acting with excitement you cannot control, trembling or shaking, twitching, and vomiting.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Isocarboxazid	Possible severe adverse reaction with this combination
Vilazodone	Due to risks of enhanced serotonin activity and/or adverse reactions (e.g., serotonin syndrome), concomitant use of selective serotonin reuptake inhibitors (SSRIs) and tryptophan is not recommended. Avoid combination.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and L-tryptophan, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Not Available

Tryptophanyl-tRNA synthetase, mitochondrial
Name	Tryptophanyl-tRNA synthetase, mitochondrial
Gene Name	WARS2
Pharmacological action	unknown
Actions	inhibitor
References	Paley EL, Denisova G, Sokolova O, Posternak N, Wang X, Brownell AL: Tryptamine Induces Tryptophanyl-tRNA Synthetase-Mediated Neurodegeneration With Neurofibrillary Tangles in Human Cell and Mouse Models. Neuromolecular Med. 2007;9(1):55-82. - Pubmed Retailleau P, Weinreb V, Hu M, Carter CW Jr: Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28. Epub 2007 Mar 12. - Pubmed Banin E, Dorrell MI, Aguilar E, Ritter MR, Aderman CM, Smith AC, Friedlander J, Friedlander M: T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Invest Ophthalmol Vis Sci. 2006 May;47(5):2125-34. - Pubmed Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Kohrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P: Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. EMBO J. 2006 Jun 21;25(12):2919-29. Epub 2006 May 25. - Pubmed Charriere F, Helgadottir S, Horn EK, Soll D, Schneider A: Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6847-52. Epub 2006 Apr 24. - Pubmed
DTHybrid score	0.7385
Tryptophanyl-tRNA synthetase
Name	Tryptophanyl-tRNA synthetase
Gene Name	trpS
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Tsuchiya W, Umehara T, Kuno A, Hasegawa T: Determination of tryptophan tRNA recognition sites for tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1. Nucleic Acids Symp Ser (Oxf). 2004;(48):185-6. - Pubmed Kovaleva GK, Favorova OO, Moroz SG, Krauspe R, Kiselev LL: [Active intermediate compound of tryptophanyl-tRNA-synthetase with tryptophan] Dokl Akad Nauk SSSR. 1976;229(2):492-5. - Pubmed Kovaleva GK, Degtiarev SKh, Favorova OO: [Affinity modification of tryptophanyl-tRNA synthetase by an alkylating L-tryptophan analog] Mol Biol (Mosk). 1979 Nov-Dec;13(6):1237-46. - Pubmed
DTHybrid score	1.4435
Tryptophanyl-tRNA synthetase, cytoplasmic
Name	Tryptophanyl-tRNA synthetase, cytoplasmic
Gene Name	WARS
Pharmacological action	unknown
Actions	inhibitor
References	Tsuchiya W, Umehara T, Kuno A, Hasegawa T: Determination of tryptophan tRNA recognition sites for tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1. Nucleic Acids Symp Ser (Oxf). 2004;(48):185-6. - Pubmed Retailleau P, Weinreb V, Hu M, Carter CW Jr: Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28. Epub 2007 Mar 12. - Pubmed Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang JZ, Matsushima K, Cao Q, Zhang Y: Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. J Immunol. 2006 Dec 1;177(11):8226-33. - Pubmed Yadav MC, Burudi EM, Alirezaei M, Flynn CC, Watry DD, Lanigan CM, Fox HS: IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. Glia. 2007 Oct;55(13):1385-96. - Pubmed Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Kohrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P: Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. EMBO J. 2006 Jun 21;25(12):2919-29. Epub 2006 May 25. - Pubmed
DTHybrid score	1.5681

Tryptophan 2,3-dioxygenase
Name	Tryptophan 2,3-dioxygenase
Gene Name	TDO2
Actions	substrate
References	Rafice SA, Chauhan N, Efimov I, Basran J, Raven EL: Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase. Biochem Soc Trans. 2009 Apr;37(Pt 2):408-12. - Pubmed
DTHybrid score	0.8547
Aromatic-L-amino-acid decarboxylase
Name	Aromatic-L-amino-acid decarboxylase
Gene Name	DDC
Actions	substrate
References	Tyce GM: Origin and metabolism of serotonin. J Cardiovasc Pharmacol. 1990;16 Suppl 3:S1-7. - Pubmed
DTHybrid score	0.7191
Tryptophanyl-tRNA synthetase
Name	Tryptophanyl-tRNA synthetase
Gene Name	trpS
Actions	substrate,inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Tsuchiya W, Umehara T, Kuno A, Hasegawa T: Determination of tryptophan tRNA recognition sites for tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1. Nucleic Acids Symp Ser (Oxf). 2004;(48):185-6. - Pubmed Kovaleva GK, Favorova OO, Moroz SG, Krauspe R, Kiselev LL: [Active intermediate compound of tryptophanyl-tRNA-synthetase with tryptophan] Dokl Akad Nauk SSSR. 1976;229(2):492-5. - Pubmed Kovaleva GK, Degtiarev SKh, Favorova OO: [Affinity modification of tryptophanyl-tRNA synthetase by an alkylating L-tryptophan analog] Mol Biol (Mosk). 1979 Nov-Dec;13(6):1237-46. - Pubmed
DTHybrid score	1.4435
Tryptophanyl-tRNA synthetase, mitochondrial
Name	Tryptophanyl-tRNA synthetase, mitochondrial
Gene Name	WARS2
Actions	substrate,inhibitor
References	Paley EL, Denisova G, Sokolova O, Posternak N, Wang X, Brownell AL: Tryptamine Induces Tryptophanyl-tRNA Synthetase-Mediated Neurodegeneration With Neurofibrillary Tangles in Human Cell and Mouse Models. Neuromolecular Med. 2007;9(1):55-82. - Pubmed Retailleau P, Weinreb V, Hu M, Carter CW Jr: Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28. Epub 2007 Mar 12. - Pubmed Banin E, Dorrell MI, Aguilar E, Ritter MR, Aderman CM, Smith AC, Friedlander J, Friedlander M: T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Invest Ophthalmol Vis Sci. 2006 May;47(5):2125-34. - Pubmed Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Kohrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P: Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. EMBO J. 2006 Jun 21;25(12):2919-29. Epub 2006 May 25. - Pubmed Charriere F, Helgadottir S, Horn EK, Soll D, Schneider A: Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6847-52. Epub 2006 Apr 24. - Pubmed
DTHybrid score	0.7385
Tryptophan 5-hydroxylase 1
Name	Tryptophan 5-hydroxylase 1
Gene Name	TPH1
Actions	substrate
References	Pavon JA, Fitzpatrick PF: Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation. Biochemistry. 2006 Sep 12;45(36):11030-7. - Pubmed Langfort J, Baranczuk E, Pawlak D, Chalimoniuk M, Lukacova N, Marsala J, Gorski J: The effect of endurance training on regional serotonin metabolism in the brain during early stage of detraining period in the female rat. Cell Mol Neurobiol. 2006 Oct-Nov;26(7-8):1327-42. Epub 2006 Aug 1. - Pubmed Nakamura K, Hasegawa H: Developmental role of tryptophan hydroxylase in the nervous system. Mol Neurobiol. 2007 Feb;35(1):45-54. - Pubmed Invernizzi RW: Role of TPH-2 in brain function: News from behavioral and pharmacologic studies. J Neurosci Res. 2007 May 10;. - Pubmed Neckameyer WS, Coleman CM, Eadie S, Goodwin SF: Compartmentalization of neuronal and peripheral serotonin synthesis in Drosophila melanogaster. Genes Brain Behav. 2007 Mar 21;. - Pubmed
DTHybrid score	0.7779
Tryptophan 5-hydroxylase 2
Name	Tryptophan 5-hydroxylase 2
Gene Name	TPH2
Actions	substrate
References	Lopez VA, Detera-Wadleigh S, Cardona I, Kassem L, McMahon FJ: Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biol Psychiatry. 2007 Jan 15;61(2):181-6. Epub 2006 Jun 27. - Pubmed Kraus MR, Al-Taie O, Schafer A, Pfersdorff M, Lesch KP, Scheurlen M: Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C. Gastroenterology. 2007 Apr;132(4):1279-86. Epub 2007 Feb 25. - Pubmed Nakamura K, Hasegawa H: Developmental role of tryptophan hydroxylase in the nervous system. Mol Neurobiol. 2007 Feb;35(1):45-54. - Pubmed Invernizzi RW: Role of TPH-2 in brain function: News from behavioral and pharmacologic studies. J Neurosci Res. 2007 May 10;. - Pubmed Calcagno E, Canetta A, Guzzetti S, Cervo L, Invernizzi RW: Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem. 2007 Jul 31;. - Pubmed
DTHybrid score	0.7426
Tryptophanyl-tRNA synthetase, cytoplasmic
Name	Tryptophanyl-tRNA synthetase, cytoplasmic
Gene Name	WARS
Actions	substrate,inhibitor
References	Tsuchiya W, Umehara T, Kuno A, Hasegawa T: Determination of tryptophan tRNA recognition sites for tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1. Nucleic Acids Symp Ser (Oxf). 2004;(48):185-6. - Pubmed Retailleau P, Weinreb V, Hu M, Carter CW Jr: Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28. Epub 2007 Mar 12. - Pubmed Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang JZ, Matsushima K, Cao Q, Zhang Y: Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. J Immunol. 2006 Dec 1;177(11):8226-33. - Pubmed Yadav MC, Burudi EM, Alirezaei M, Flynn CC, Watry DD, Lanigan CM, Fox HS: IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. Glia. 2007 Oct;55(13):1385-96. - Pubmed Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Kohrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P: Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. EMBO J. 2006 Jun 21;25(12):2919-29. Epub 2006 May 25. - Pubmed
DTHybrid score	1.5681
Indoleamine 2,3-dioxygenase
Name	Indoleamine 2,3-dioxygenase
Gene Name	IDO1
Actions	substrate
References	Agaugue S, Perrin-Cocon L, Coutant F, Andre P, Lotteau V: 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J Immunol. 2006 Aug 15;177(4):2061-71. - Pubmed Fallarino F, Gizzi S, Mosci P, Grohmann U, Puccetti P: Tryptophan catabolism in IDO+ plasmacytoid dendritic cells. Curr Drug Metab. 2007 Apr;8(3):209-16. - Pubmed Cozzi A, Zignego AL, Carpendo R, Biagiotti T, Aldinucci A, Monti M, Giannini C, Rosselli M, Laffi G, Moroni F: Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. J Viral Hepat. 2006 Jun;13(6):402-8. - Pubmed Grohmann U, Volpi C, Fallarino F, Bozza S, Bianchi R, Vacca C, Orabona C, Belladonna ML, Ayroldi E, Nocentini G, Boon L, Bistoni F, Fioretti MC, Romani L, Riccardi C, Puccetti P: Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med. 2007 May;13(5):579-86. Epub 2007 Apr 8. - Pubmed Zheng X, Koropatnick J, Li M, Zhang X, Ling F, Ren X, Hao X, Sun H, Vladau C, Franek JA, Feng B, Urquhart BL, Zhong R, Freeman DJ, Garcia B, Min WP: Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference. J Immunol. 2006 Oct 15;177(8):5639-46. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Rafice SA, Chauhan N, Efimov I, Basran J, Raven EL: Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase. Biochem Soc Trans. 2009 Apr;37(Pt 2):408-12. - Pubmed
DTHybrid score	0.6481

Monocarboxylate transporter 8
Name	Monocarboxylate transporter 8
Gene Name	SLC16A2
Actions	inhibitor
References	Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. - Pubmed
DTHybrid score	0.5494
Monocarboxylate transporter 10
Name	Monocarboxylate transporter 10
Gene Name	SLC16A10
Actions	inhibitor
References	Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. - Pubmed Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score	0.6549

Id	Partner name	Gene Name	Score
1729	Solute carrier family 22 member 6	SLC22A6	0.1255
676	Tyrosine 3-monooxygenase	TH	0.1224
828	Phenylalanine-4-hydroxylase	PAH	0.0893
3109	Phenylalanine-4-hydroxylase	phhA	0.0893
7	Nitric oxide synthase, inducible	NOS2	0.088
290	Prostaglandin G/H synthase 2	PTGS2	0.0812
1757	Myeloperoxidase	MPO	0.0714
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0706
807	D-alanine--D-alanine ligase A	ddlA	0.0692
894	Alanine racemase	alr	0.0691
2453	Alanine racemase	alr	0.0691
399	Tyrosyl-tRNA synthetase, mitochondrial	YARS2	0.0654
763	Tyrosine aminotransferase	TAT	0.056
5493	Tyrosine aminotransferase	Not Available	0.056
291	Nitric-oxide synthase, endothelial	NOS3	0.0533
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0515
6034	Hydroxyindole O-methyltransferase	ASMT	0.0498
6035	Nuclear receptor ROR-beta	RORB	0.0498
6036	Eosinophil peroxidase	EPX	0.0498
501	Leucine carboxyl methyltransferase 1	LCMT1	0.0467
675	Leucine carboxyl methyltransferase 2	LCMT2	0.0466
846	Leucyl-tRNA synthetase, cytoplasmic	LARS	0.0466
227	Probable leucyl-tRNA synthetase, mitochondrial	LARS2	0.0466
256	Tyrosyl-tRNA synthetase, cytoplasmic	YARS	0.0425
3830	Calreticulin	CALR	0.0424
1566	Corticoliberin	CRH	0.0413
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0391
20	Prostaglandin G/H synthase 1	PTGS1	0.0376
594	Thyroxine-binding globulin	SERPINA7	0.0365
362	Melatonin receptor type 1B	MTNR1B	0.0352
571	Melatonin receptor type 1A	MTNR1A	0.0351
831	D(2) dopamine receptor	DRD2	0.035
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0333
758	Thyroid hormone receptor alpha	THRA	0.0327
1588	Multidrug resistance protein 1	ABCB1	0.0304
2532	Pantoate--beta-alanine ligase	panC	0.0285
346	Thyroid hormone receptor beta-1	THRB	0.0267
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0264
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.026
23	D(1A) dopamine receptor	DRD1	0.0254
6142	Solute carrier family 22 member 8	SLC22A8	0.0246
6645	D-amino-acid oxidase	DAO	0.0245
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0241
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0235
5925	Neuropeptide Y	NPY	0.0231
314	System N amino acid transporter 1	SLC38A3	0.0229
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0227
694	Matrix protein 2	M	0.0226
397	Monocarboxylate transporter 3	SLC16A8	0.0218
195	Monocarboxylate transporter 7	SLC16A6	0.0218
218	Monocarboxylate transporter 5	SLC16A4	0.0218
429	Monocarboxylate transporter 6	SLC16A5	0.0217
556	Alpha-1A adrenergic receptor	ADRA1A	0.0216
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.02
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0198
4069	Threonyl-tRNA synthetase, mitochondrial	TARS2	0.0197
261	Threonyl-tRNA synthetase, cytoplasmic	TARS	0.0197
246	Valyl-tRNA synthetase	VARS	0.0196
465	Calmodulin	CALM1	0.0195
500	Monocarboxylate transporter 4	SLC16A3	0.0193
373	Transthyretin	TTR	0.0192
489	Monocarboxylate transporter 2	SLC16A7	0.0192
1898	Cytochrome P450 1B1	CYP1B1	0.018
534	Threonine synthase-like 1	THNSL1	0.0178
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0177
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0176
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0172
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0171
3811	Cytochrome P450 19A1	CYP19A1	0.017
301	Kynurenine--oxoglutarate transaminase 1	CCBL1	0.017
5469	Head decoration protein	shp	0.0168
52	Pyruvate kinase isozymes R/L	PKLR	0.0166
738	Monocarboxylate transporter 1	SLC16A1	0.0165
771	Pyruvate carboxylase, mitochondrial	PC	0.0165
2457	Bacillolysin	nprS	0.016
136	Estrogen receptor	ESR1	0.0157
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.0157
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0151
587	Serum albumin	ALB	0.0148
815	Histidyl-tRNA synthetase, cytoplasmic	HARS	0.0147
96	Histidine ammonia-lyase	HAL	0.0147
6257	Histidine ammonia-lyase	Not Available	0.0147
6536	Histidine ammonia-lyase	hutH	0.0147
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0147
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0147
6024	Cytochrome P450 1A1	CYP1A1	0.0147
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0146
1517	Beta-3 adrenergic receptor	ADRB3	0.0144
3	Histidine decarboxylase	HDC	0.0144
38	Cystinosin	CTNS	0.0141
3998	B(0,+)-type amino acid transporter 1	SLC7A9	0.0141
1963	Neutral and basic amino acid transport protein rBAT	SLC3A1	0.0141
163	D(1B) dopamine receptor	DRD5	0.0141
150	Cationic amino acid transporter 3	SLC7A3	0.0137
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0137
58	Cationic amino acid transporter 4	SLC7A4	0.0137
349	Serine--pyruvate aminotransferase	AGXT	0.0135
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0134
6141	Sodium/bile acid cotransporter	SLC10A1	0.0133
432	D(4) dopamine receptor	DRD4	0.0133
3939	Amine oxidase [flavin-containing] B	MAOB	0.0132
502	5-hydroxytryptamine 2A receptor	HTR2A	0.013
358	Cystathionine beta-synthase	CBS	0.013
638	D(3) dopamine receptor	DRD3	0.0129
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0126
4924	Cytochrome P450 2C8	CYP2C8	0.0124
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0124
6016	Cytochrome P450 2C19	CYP2C19	0.0123
4200	Cytochrome P450 1A2	CYP1A2	0.0122
3977	ASRGL1 protein	ASRGL1	0.0121
263	Neutral amino acid transporter B(0)	SLC1A5	0.0119
4757	Cytochrome P450 2C9	CYP2C9	0.0117
6144	Solute carrier family 22 member 2	SLC22A2	0.0115
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0113
789	Alpha-1D adrenergic receptor	ADRA1D	0.0111
6145	Solute carrier family 22 member 1	SLC22A1	0.011
701	Isoleucine-tRNA synthetase	IARS	0.011
546	Isoleucyl-tRNA synthetase, cytoplasmic	IARS	0.011
4080	Isoleucyl-tRNA synthetase, mitochondrial	IARS2	0.011
221	Lysyl-tRNA synthetase	KARS	0.0109
378	Alpha-2C adrenergic receptor	ADRA2C	0.0108
4092	Probable asparaginyl-tRNA synthetase, mitochondrial	NARS2	0.0107
669	Asparaginyl-tRNA synthetase, cytoplasmic	NARS	0.0107
629	Alpha-2B adrenergic receptor	ADRA2B	0.0106
169	Cysteine desulfurase, mitochondrial	NFS1	0.0105
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0103
193	Beta-1 adrenergic receptor	ADRB1	0.0102
184	L-serine dehydratase	SDS	0.0102
431	Serine racemase	SRR	0.0102
491	Serine palmitoyltransferase 1	SPTLC1	0.0102
727	Serine palmitoyltransferase 2	SPTLC2	0.0102
5650	NimA-related protein	DR_0842	0.0101
766	Beta-2 adrenergic receptor	ADRB2	0.01
632	Alpha-1B adrenergic receptor	ADRA1B	0.01
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0099
72	Seryl-tRNA synthetase, cytoplasmic	SARS	0.0099
33	Cystine/glutamate transporter	SLC7A11	0.0098
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0097
42	Phenylalanyl-tRNA synthetase alpha chain	FARSA	0.0096
6602	Phenylalanyl-tRNA synthetase alpha chain	pheS	0.0096
31	Phenylalanyl-tRNA synthetase, mitochondrial	FARS2	0.0096
618	Phenylalanyl-tRNA synthetase beta chain	FARSB	0.0096
6603	Phenylalanyl-tRNA synthetase beta chain	pheT	0.0096
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0095
318	Alpha-2A adrenergic receptor	ADRA2A	0.0095
482	Glycine receptor subunit alpha-1	GLRA1	0.0093
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0093
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0086
2838	Ribose-5-phosphate isomerase A	rpiA	0.008
2952	Ribose-5-phosphate isomerase A	rpiA	0.008
5595	Ribose-5-phosphate isomerase A	rpiA	0.008
5590	N utilization substance protein B homolog	nusB	0.008
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.008
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.008
5591	Complement component C8 gamma chain	C8G	0.008
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.008
5582	Regulator of transcription; stringent starvation protein A	sspA	0.008
4238	50S ribosomal protein L4	rplD	0.008
5578	50S ribosomal protein L4	rplD	0.008
6173	50S ribosomal protein L4	rplD	0.008
6219	50S ribosomal protein L4	rplD	0.008
4695	UPF0124 protein yfiH	yfiH	0.008
5588	Cell division protein FtsY	TM_0570	0.008
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.008
2300	Lysozyme	E	0.008
3633	Lysozyme	R	0.008
5597	Lysozyme	17	0.008
5587	Iron(III)-binding periplasmic protein	fbpA	0.008
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.008
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.008
5593	Transferase	Not Available	0.008
5581	Beta-fructosidase	bfrA	0.008
5060	Intron-associated endonuclease 1	ITEVIR	0.008
4375	Glutamine synthetase 1	glnA1	0.008
5575	Short tail fiber protein	12	0.008
5600	Pyruvate decarboxylase	pdc	0.008
5580	Hexon protein	PII	0.008
5574	Invasin	YPTB1668	0.008
4119	Cytochrome P450 2D6	CYP2D6	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0077
833	Organic cation/carnitine transporter 1	SLC22A4	0.0075
499	Arginine decarboxylase	ADC	0.0074
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0073
4992	Cytochrome c peroxidase	Not Available	0.0073
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0073
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0073
3132	Tryptophan synthase alpha chain	trpA	0.0071
6568	Tryptophan synthase alpha chain	trpA	0.0071
5006	RNASE4 protein	RNASE4	0.007
2555	Pol polyprotein	pol	0.007
3242	Pol polyprotein	gag-pol	0.007
3471	Pol polyprotein	gag-pro-pol	0.007
5256	Pol polyprotein	pol	0.007
6469	Pol polyprotein	gag-pol	0.007
6565	Pol polyprotein	Not Available	0.007
3899	Alanine--glyoxylate aminotransferase 2-like 2	AGXT2L2	0.007
4533	Glyoxalase family protein	BC_1747	0.007
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.007
5328	Prostaglandin F synthase	Tb11.02.2310	0.007
3729	Citrate synthase	gltA	0.0069
4575	Citrate synthase	cit	0.0069
4580	Citrate synthase	gltA	0.0069
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0069
735	Alanine aminotransferase 1	GPT	0.0068
3904	Alanine aminotransferase 2	GPT2	0.0068
411	Glycine N-methyltransferase	GNMT	0.0068
740	Argininosuccinate synthase	ASS1	0.0067
865	Argininosuccinate synthase	ASS1	0.0067
2680	Argininosuccinate synthase	argG	0.0067
3194	Argininosuccinate synthase	argG	0.0067
89	Cysteine sulfinic acid decarboxylase	CSAD	0.0067
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0066
435	Kynureninase	KYNU	0.0066
4654	Kynureninase	kynU	0.0066
2603	Beta-lactamase II	blm	0.0065
2149	Angiogenin	ANG	0.0064
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0064
2521	Cell division protein ftsZ	ftsZ	0.0064
3301	Cell division protein ftsZ	ftsZ	0.0064
3583	6-phosphogluconolactonase	pgl	0.0064
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0062
3486	Fumarate hydratase class II	fumC	0.0061
2286	Isocitrate dehydrogenase [NADP]	icd	0.0061
2302	Isocitrate dehydrogenase [NADP]	icd	0.0061
2771	Isocitrate dehydrogenase [NADP]	icd	0.0061
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.006
2942	Sialidase	nanH	0.006
3546	Sialidase	nedA	0.006
857	Malate dehydrogenase, mitochondrial	MDH2	0.0059
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0058
1123	Eosinophil cationic protein	RNASE3	0.0058
532	Neutral amino acid transporter A	SLC1A4	0.0057
4070	Probable alanyl-tRNA synthetase, mitochondrial	AARS2	0.0057
323	Alanyl-tRNA synthetase, cytoplasmic	AARS	0.0057
868	Cystathionine gamma-lyase	CTH	0.0057
332	Beta-lactamase	blaZ	0.0057
2478	Beta-lactamase	ampC	0.0057
2613	Beta-lactamase	ampC	0.0057
2635	Beta-lactamase	ampC	0.0057
2700	Beta-lactamase	penP	0.0057
5445	Beta-lactamase	blaB	0.0057
6019	Beta-lactamase	SHV-7	0.0057
6701	Beta-lactamase	cphA	0.0057
2697	Uridine-cytidine kinase 2	UCK2	0.0057
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0056
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0056
5682	Ribonuclease pancreatic	RNASE1	0.0056
3877	Growth-inhibiting protein 18	GIG18	0.0055
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0054
3874	Proline synthetase co-transcribed bacterial homolog protein	PROSC	0.0053
5579	Carboxypeptidase B	CPB1	0.0053
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0053
171	Cysteine dioxygenase	CDO-1	0.0053
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
774	Cysteinyl-tRNA synthetase, cytoplasmic	CARS	0.0052
1314	Thiamine transporter 2	SLC19A3	0.0052
4064	Probable cysteinyl-tRNA synthetase, mitochondrial	CARS2	0.0052
207	Glutathione synthetase	GSS	0.0052
5269	Glutathione synthetase	gshB	0.0052
3384	Macrophage migration inhibitory factor	MIF	0.0052
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0052
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0052
834	Arginase-2, mitochondrial	ARG2	0.0051
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0051
577	Argininosuccinate lyase	ASL	0.0049
3971	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	CAD	0.0049
128	Adenine phosphoribosyltransferase	APRT	0.0048
480	Methionine-R-sulfoxide reductase B2	MSRB2	0.0048
317	Methionine-R-sulfoxide reductase	SEPX1	0.0048
3996	Betaine--homocysteine S-methyltransferase 2	BHMT2	0.0048
3921	Methionine adenosyltransferase 2 subunit beta	MAT2B	0.0048
3995	Methionyl-tRNA synthetase, mitochondrial	MARS2	0.0048
600	Methionyl-tRNA synthetase, cytoplasmic	MARS	0.0048
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0046
4512	Cytochrome P450 3A4	CYP3A4	0.0046
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0043
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0043
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0043
1999	Methylated-DNA--protein-cysteine methyltransferase	MGMT	0.0043
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0041
191	Peptide methionine sulfoxide reductase	MSRA	0.0041
822	Aldose reductase	AKR1B1	0.004
626	Cysteine dioxygenase type 1	CDO1	0.004
3884	SHMT2 protein	SHMT2	0.0039
3901	SHMT2 protein	SHMT2	0.0039
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0039
3879	Serine hydroxymethyltransferase 2	Not Available	0.0039
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0039
3893	DDC protein	DDC	0.0038
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0038
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0037
3891	Putative L-Dopa decarboxylase	DDC	0.0037
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0036
4085	Peptidyl-prolyl cis-trans isomerase C	PPIC	0.0035
4088	Probable prolyl-tRNA synthetase, mitochondrial	PARS2	0.0035
4083	Peptidyl-prolyl cis-trans isomerase H	PPIH	0.0035
4087	Pyrroline 5-carboxylate reductase isoform	P5CR2	0.0035
4090	Chromosome 14 open reading frame 149	C14orf149	0.0035
4082	Proline oxidase, mitochondrial	PRODH	0.0035
797	Sodium-dependent proline transporter	SLC6A7	0.0035
4086	Peptidyl-prolyl cis-trans isomerase G	PPIG	0.0035
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0034
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0034
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0034
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0034
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0034
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0034
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0034
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0034
420	Glutamate decarboxylase 1	GAD1	0.0034
3900	Glutamate decarboxylase 1	GAD1	0.0034
665	Phosphoserine aminotransferase	PSAT1	0.0034
4652	Phosphoserine aminotransferase	serC	0.0034
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0034
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0034
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0034
1671	Excitatory amino acid transporter 3	SLC1A1	0.0033
840	Methionine synthase reductase, mitochondrial	MTRR	0.0033
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0031
2632	Adenylosuccinate synthetase	purA	0.0031
3323	Adenylosuccinate synthetase	purA	0.0031
3975	Adenylosuccinate synthetase	ADSS	0.0031
4598	Adenylosuccinate synthetase	Adss	0.0031
6817	Adenylosuccinate synthetase	purA	0.0031
3972	Adenylosuccinate synthetase isozyme 2	ADSS	0.0031
533	Aminoacylase-1	ACY1	0.0031
3969	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase	PAICS	0.0031
799	Aspartyl-tRNA synthetase, cytoplasmic	DARS	0.0031
209	Aspartoacylase	ASPA	0.0031
3979	Aspartoacylase-2	ACY3	0.0031
3976	Aspartyl-tRNA synthetase, mitochondrial	DARS2	0.0031
513	Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	0.0031
305	Mitochondrial aspartate-glutamate carrier protein	SLC25A13	0.0031
262	Calcium-binding mitochondrial carrier protein Aralar1	SLC25A12	0.0031
3908	P-selectin cytoplasmic tail-associated protein	pcap	0.0031
3896	CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase	GADL1	0.0031
3911	Uncharacterized protein C20orf38	SPTLC3	0.0031
3906	Serine dehydratase-like	SDSL	0.0031
3881	Selenocysteine lyase variant	Not Available	0.0031
3887	Phosphorylase	PYGB	0.0031
3915	Cysteine sulfinic acid decarboxylase-related protein 1	CSAD	0.0031
3914	Alanine-glyoxylate aminotransferase homolog	TLH6	0.0031
3878	GAD1 protein	GAD1	0.0031
3883	Ornithine aminotransferase variant	Not Available	0.0031
306	Pyridoxal phosphate phosphatase	PDXP	0.0031
3909	Hepatic peroxysomal alanine:glyoxylate aminotransferase	Not Available	0.0031
855	Sphingosine-1-phosphate lyase 1	SGPL1	0.0031
809	Methionine synthase	MTR	0.0031
2935	Methionine synthase	metH	0.0031
3880	Serine hydroxymethyltransferase 1	Not Available	0.0031
3910	O-phosphoseryl-tRNA(Sec) selenium transferase	SEPSECS	0.0031
3894	KIAA0251 protein	PDXDC1	0.0031
3875	Glycogen phosphorylase, brain form	PYGB	0.0031
3882	Brain glycogen phosphorylase variant	Not Available	0.0031
3903	Aminolevulinate, delta-, synthase 2	ALAS2	0.0031
3886	Migration-inducing protein 4	ALAS1	0.0031
3905	Molybdenum cofactor sulfurase	MOCOS	0.0031
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.003
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.003
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0029
1008	CTP synthase 1	CTPS	0.0029
3988	Protein-glutamine gamma-glutamyltransferase K	TGM1	0.0029
3985	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2	GFPT2	0.0029
3990	Protein-glutamine gamma-glutamyltransferase 4	TGM4	0.0029
3986	Protein-glutamine gamma-glutamyltransferase 6	TGM6	0.0029
3992	Protein-glutamine gamma-glutamyltransferase Z	TGM7	0.0029
3983	Protein-glutamine gamma-glutamyltransferase 5	TGM5	0.0029
3989	Glutaminyl-tRNA synthetase	QARS	0.0029
3913	Glutamic acid decarboxylase	GAD65	0.0027
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0027
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0027
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0027
2554	Peptidyl-prolyl cis-trans isomerase, mitochondrial	PPIF	0.0027
2795	Methionine aminopeptidase 2	METAP2	0.0026
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0026
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.0025
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.0025
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.0025
1596	Protein-glutamine gamma-glutamyltransferase 2	TGM2	0.0024
118	Organic cation/carnitine transporter 2	SLC22A5	0.0024
6	Coagulation factor XIII A chain	F13A1	0.0024
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0023
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0023
472	Ornithine aminotransferase, mitochondrial	OAT	0.0023
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0023
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0023
413	Amidophosphoribosyltransferase	PPAT	0.0023
2515	Amidophosphoribosyltransferase	purF	0.0023
3714	Amidophosphoribosyltransferase	purF	0.0023
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0022
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0022
4057	Glycine N-acyltransferase	GLYAT	0.0022
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0022
4056	N-arachidonyl glycine receptor	GPR18	0.0022
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0022
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0022
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0022
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0022
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0022
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0022
1466	Glycyl-tRNA synthetase	GARS	0.0022
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.0021
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.002
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.002
449	Ornithine decarboxylase	ODC1	0.002
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0019
10	Glycogen phosphorylase, liver form	PYGL	0.0018
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0017
62	Glycine receptor subunit beta	GLRB	0.0017
383	Glycine amidinotransferase, mitochondrial	GATM	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0014
1152	Glycogen phosphorylase, muscle form	PYGM	0.0014
461	Glycine receptor subunit alpha-3	GLRA3	0.0014
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0011
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0011
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0011
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0011
664	Glutamate decarboxylase 2	GAD2	0.0011
3890	Glutamate decarboxylase 2	GAD2	0.0011
4026	Aspartyl aminopeptidase	DNPEP	0.0011
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0011
1912	Excitatory amino acid transporter 1	SLC1A3	0.0011
4016	Excitatory amino acid transporter 5	SLC1A7	0.0011
4019	Excitatory amino acid transporter 4	SLC1A6	0.0011
4017	5-oxoprolinase	OPLAH	0.0011
1047	Excitatory amino acid transporter 2	SLC1A2	0.0011
926	Metabotropic glutamate receptor 7	GRM7	0.0011
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0011
4018	Glutamate receptor delta-2 subunit	GRID2	0.0011
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0011
922	Glutamate receptor 4	GRIA4	0.0011
927	Metabotropic glutamate receptor 8	GRM8	0.0011
925	Metabotropic glutamate receptor 4	GRM4	0.0011
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0011
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0011
4020	Glutamyl aminopeptidase	ENPEP	0.0011
4027	Glutamate receptor delta-1 subunit	GRID1	0.0011
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0009
625	Glutamate carboxypeptidase 2	FOLH1	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
916	Metabotropic glutamate receptor 1	GRM1	0.0008
923	Glutamate receptor 3	GRIA3	0.0008
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0008
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0008
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0008
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0007
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0007
705	Glutamate receptor 1	GRIA1	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0005
921	Glutamate receptor 2	GRIA2	0.0005

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00150 - L-Tryptophan

Targets

Enzymes

Transporters

Predictions