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Adenylosuccinate synthetase isozyme 1


Partner ID 3978
Name Adenylosuccinate synthetase isozyme 1
Synonyms 6211
Gene name ADSSL1
General function Nucleotide transport and metabolism
Specific function Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Gene sequence + ...

ATGTCGGGGACCCGAGCCTCCAACGACCGGCCCCCCGGCGCAGGCGGCGTCAAGCGGGGGCGGCTGCAGCAGGAGGCGGCGGCGACCGGCTCCCGCGTGACGGTGGTGCTGGGCGCGCAGTGGGGGGACGAGGGCAAAGGCAAGGTGGTGGACCTGCTGGCCACGGACGCCGACATCATCAGCCGCTGCCAGGGGGGCAACAACGCCGGCCACACGGTGGTGGTGGATGGGAAAGAGTACGACTTCCACCTGCTGCCCAGCGGCATCATCAACACCAAGGCCGTGTCCTTCATTGGCAACGGGGTGGTCATCCACTTGCCAGGCTTGTTTGAGGAAGCAGAGAAGAATGAAAAGAAAGGCCTGAAGGACTGGGAGAAGAGGCTCATCATCTCTGACAGAGCCCACCTTGTGTTTGATTTTCACCAGGCTGTCGACGGACTTCAGGAAGTGCAGCGCCAGGCACAAGAGGGGAAGAATATAGGCACCACCAAGAAGGGAATCGGACCAACCTACTCTTCCAAAGCTGCCCGGACAGGCCTCCGCATCTGCGACCTCCTGTCAGATTTTGATGAGTTTTCCTCCAGATTCAAGAACCTGGCCCACCAGCACCAGTCGATGTTCCCCACCCTGGAAATAGACATTGAAGGCCAACTCAAAAGGCTCAAGGGCTTTGCTGAGCGGATCAGACCCATGGTCCGAGATGGTGTTTACTTTATGTATGAGGCACTCCACGGCCCCCCCAAGAAGATCCTGGTGGAGGGTGCCAACGCCGCCCTCCTCGACATTGACTTCGGGACCTACCCCTTTGTGACTTCATCCAACTGCACCGTGGGCGGTGTGTGCACGGGCCTGGGCATCCCCCCGCAGAACATAGGTGACGTGTATGGCGTGGTGAAAGCCTATACCACACGTGTGGGCATCGGGGCCTTCCCCACCGAGCAGATCAACGAGATTGGAGGCCTGCTGCAGACCCGCGGCCACGAGTGGGGAGTGACCACAGGCAGGAAGAGGCGCTGCGGCTGGCTCGACCTGATGATTCTAAGATATGCTCACATGGTCAACGGATTCACTGCGCTGGCCCTGACGAAGCTGGACATCCTGGACGTACTGGGTGAGGTTAAAGTCGGTGTCTCATACAAGCTGAACGGGAAAAGGATTCCCTATTTCCCAGCTAACCAGGAGATGCTTCAGAAGGTCGAAGTTGAGTATGAAACGCTGCCTGGGTGGAAAGCAGACACCACAGGCGCCAGGAGGTGGGAGGACCTGCCCCCACAGGCCCAGAACTACATCCGCTTTGTGGAGAATCACGTGGGAGTCGCAGTCAAATGGGTTGGTGTTGGCAAGTCAAGAGAGTCGATGATCCAGCTGTTTTAG
Protein sequence + ...

MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQLF
GO Classification
function
guanyl nucleotide binding
GTP binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
binding
nucleotide binding
adenylosuccinate synthase activity
catalytic activity
purine nucleotide binding
process
nucleotide metabolism
purine nucleotide metabolism
physiological process
purine nucleotide biosynthesis
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00128 L-Aspartic Acid
DB02109 Hadacidin
DB03510 6-O-Phosphoryl Inosine Monophosphate
DB04137 Guanosine-5'-Triphosphate
DB04315 Guanosine-5'-Diphosphate
DB04418 Adenylosuccinic Acid
DB04566 Inosinic Acid

Associated as Prediction

Id Name
DB00114 Pyridoxal Phosphate
DB00117 L-Histidine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00123 L-Lysine
DB00125 L-Arginine
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00139 Succinic acid
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00155 L-Citrulline
DB00156 L-Threonine
DB00157 NADH
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00171 Adenosine triphosphate
DB00172 L-Proline
DB00174 L-Asparagine
DB00230 Pregabalin
DB00279 Liothyronine
DB00300 Tenofovir
DB00536 Guanidine
DB00688 Mycophenolate mofetil
DB00709 Lamivudine
DB00718 Adefovir Dipivoxil
DB00756 Hexachlorophene
DB01024 Mycophenolic acid
DB01235 Levodopa
DB01583 Liotrix
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01693 Ribavirin Monophosphate
DB01746 D-Leucine
DB01786 D-Alanine
DB01812 Adenosine-3'-5'-Diphosphate
DB01823 Beta-D-Glucopyranose Spirohydantoin
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01843 3-Amino-8,9,10-Trihydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01961 Cytidine-3'-Monophosphate
DB01972 Guanosine-5'-Monophosphate
DB02007 Alpha-D-Glucose-6-Phosphate
DB02059 Adenosine-5-Diphosphoribose
DB02098 Adenosine-2'-5'-Diphosphate
DB02109 Hadacidin
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB02210 Hexane-1,6-Diol
DB02212 Pyrophosphate 2-
DB02320 1-N-Acetyl-Beta-D-Glucosamine
DB02331 (2s)-2-[(5-Benzofuran-2-Yl-Thiophen-2-Ylmethyl)-(2,4-Dichloro-Benzoyl)-Amino]-3-Phenyl-Propionic Acid
DB02345 Selenocysteine
DB02348 Fluoro-Phosphite Ion
DB02363 2'-Monophosphoadenosine-5'-Diphosphate
DB02379 Beta-D-Glucose
DB02393 D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate
DB02447 3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB02471 Nojirimycine Tetrazole
DB02493 Hydantocidin-5'-Phosphate
DB02515 3-Phosphoglycerol
DB02519 Indirubin-5-Sulphonate
DB02547 Guanosine-5'-Diphosphate-Rhamnose
DB02556 D-Phenylalanine
DB02569 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
DB02573 2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate
DB02604 2-Deoxy-Glucose-6-Phosphate
DB02607 Adenosine Phosphonoacetic Acid
DB02666 (C8-R)-Hydantocidin 5'-Phosphate
DB02682 2-Deamino-6-Deoxy-6thiophosphite-5'-Phosphate Guanosine
DB02703 Fusidic Acid
DB02714 3'-Uridinemonophosphate
DB02719 C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide
DB02720 Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide
DB02750 S-(Methylmercury)-L-Cysteine
DB02774 1,3-Propandiol
DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB02805 1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB02836 Guanosine 5'-Diphosphate 2':3'-Cyclic Monophosphate
DB02843 Alpha-D-Glucose-1-Phosphate
DB02887 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate
DB02930 Phosphothiophosphoric Acid-Adenylate Ester
DB02952 Alpha-Aminoisobutyric Acid
DB02954 (Carboxyhydroxyamino)Ethanoic Acid
DB02964 8,9,10-Trihydroxy-7-Hydroxymethyl-2-Thioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Decan-4-One
DB02975 Ge2270a
DB02987 Cysteine-S-Acetamide
DB02994 Hydroxydimethylarsine Oxide
DB03067 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid
DB03070 Selenazole-4-Carboxyamide-Adenine Dinucleotide
DB03103 Thymidine-5'- Diphosphate
DB03107 Beta-Alanine
DB03133 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole
DB03146 2-Deazo-6-Thiophosphate Guanosine-5'-Monophosphate
DB03152 B-2-Octylglucoside
DB03155 1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB03186 U-Pi-a-Pi
DB03203 Sphingosine
DB03218 N-Acetyl-N'-Beta-D-Glucopyranosyl Urea
DB03223 Diphthamide
DB03225 D-Tryptophan
DB03226 Trifluoroethanol
DB03250 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole
DB03286 C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide
DB03326 deoxycytidylyl-3',5'-guanosine
DB03354 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole
DB03383 5-Chloro-1h-Indole-2-Carboxylic Acid [1-(4-Fluorobenzyl)-2-(4-Hydroxypiperidin-1yl)-2-Oxoethyl]Amide
DB03392 (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester
DB03431 Adenosine-5'-Diphosphate
DB03447 Uridylyl-2'-5'-Phospho-Adenosine
DB03448 2'-Deoxyuridine 3'-Monophosphate
DB03459 N-(Phosphonacetyl)-L-Aspartic Acid
DB03479 8,9,10-Trihydroxy-7-Hydroxymethyl-3-Methyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB03491 2'-Deoxyguanosine-5'-Diphosphate
DB03496 Flavopiridol
DB03510 6-O-Phosphoryl Inosine Monophosphate
DB03512 Uridine-2',3'-Vanadate
DB03605 (2s)-2-[(2,4-Dichloro-Benzoyl)-(3-Trifluoromethyl-Benzyl)-Amino]-3-Phenyl-Propionic Acid
DB03657 1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose
DB03726 Purine Riboside-5'-Monophosphate
DB03765 Cytidine-2'-Monophosphate
DB03792 5-Amino-1h-Pyrimidine-2,4-Dione
DB03793 Benzoic Acid
DB03835 N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide
DB03839 D-Tyrosine
DB03900 2-Methyl-2-Propanol
DB03929 D-Serine
DB03931 Diguanosine-5'-Triphosphate
DB03948 6-Chloropurine Riboside, 5'-Monophosphate
DB03963 S-(Dimethylarsenic)Cysteine
DB04005 Uridine 5'-Triphosphate
DB04013 1-Deoxy-1-Methoxycarbamido-Beta-D-Gluco-2-Heptulopyranosonamide
DB04044 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid
DB04055 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium
DB04068 Fudp
DB04077 Glycerol
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB04121 Guanosine-3'-Monophosphate-5'-Diphosphate
DB04124 Aurodox
DB04137 Guanosine-5'-Triphosphate
DB04160 Diphosphate
DB04195 Heptulose-2-Phosphate
DB04198 Formycin B
DB04272 Citric Acid
DB04295 N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea
DB04298 3-(4-Amino-2-Tert-Butyl-5-Methyl-Phenylsulfanyl)-6-Cyclopentyl-4-Hydroxy-6-[2-(4-Hydroxy-Phenyl)-Ethyl]-5,6-Dihydro-Pyran-2-One
DB04299 Maleic Acid
DB04315 Guanosine-5'-Diphosphate
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB04398 Lactic Acid
DB04418 Adenylosuccinic Acid
DB04444 Tetrafluoroaluminate Ion
DB04460 (C8-S)-Hydantocidin 5'-Phosphate
DB04464 N-Formylmethionine
DB04493 Fructose-6-Phosphate
DB04514 Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester
DB04522 Phosphonoserine
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04544 1-Deoxy-1-Acetylamino-Beta-D-Gluco-2-Heptulopyranosonamide
DB04566 Inosinic Acid
DB04642 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID
DB04643 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID
DB04644 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID
DB04645 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID
DB06262 Droxidopa
DB06974 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one
DB06986 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07062 N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide
DB07066 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07169 5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE
DB07199 (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID
DB07200 (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID
DB07238 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide
DB07348 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE
DB07414 (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one
DB07570 3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID
DB07690 (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID
DB07792 (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07793 (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07807 (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL
DB07949 ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID
DB08012 (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE
DB08013 (METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE
DB08014 (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE
DB08031 N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE
DB08151 (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol
DB08185 2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08231 MYRISTIC ACID
DB08278 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE
DB08279 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
DB08322 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
DB08390 (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE
DB08481 4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE
DB08500 (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
DB08503 (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
DB08578 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid
DB08579 4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}aniline
DB08580 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline
DB08581 4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid
DB08582 N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide
DB08596 5'-deoxy-5'-piperidin-1-ylthymidine
DB08661 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
DB08701 2-(3-BROMOPHENYL)-6-[(2-HYDROXYETHYL)AMINO]-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE
DB08706 (2S)-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)(4-FLUOROPHENYL)ACETIC ACID
DB08710 (5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE
DB08751 N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
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