DT-Web

DB01024 - Mycophenolic acid


Identification
Name Mycophenolic acid
Accession Number DB01024 (APRD01603, EXPT02208)
Type small molecule
Description Mycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 320.3371
Groups approved
Monoisotopic Weight 320.125988372
Pharmacology
Indication For the prophylaxis of organ rejection in patients receiving allogeneic renal transplants, administered in combination with cyclosporine and corticosteroids.
Mechanism of action Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, mycophenolic acid has potent cytostatic effects on lymphocytes. Mycophenolic acid inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of mycophenolic acid on lymphocytes. Mycophenolic acid also suppresses antibody formation by B-lymphocytes. Mycophenolic acid prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection.
Absorption Bioavailability following oral administration of Myfortic delayed-release tablet ranges from 70-95%
Protein binding >98%
Biotransformation Mycophenolic acid is metabolized mainly by glucuronyl transferase to glucuronidated metabolites, predominantly the phenolic glucuronide, mycophenolic acid glucuronide (MPAG). MPAG does not manifest pharmacological activity. The acyl glucuronide minor metabolite has pharmacological activity similar to mycophenolic acid. The AUC ratio of Mycophenolic acid:MPAG:acyl glucuronide is approximately 1:24:0.28 at steady state.
Route of elimination Not Available
Toxicity Oral (LD50): Acute: 352 mg/kg [Rat], 1000 mg/kg [Mouse], and >6000 mg/kg [Rabbit]. Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Valganciclovir The excretion rates of Valganciclovir and/or Mycophenolic acid may decrease. Monitor for increased serum concentrations and toxicity of both agents.
Food Interactions Not Available

Targets


Inosine-5'-monophosphate dehydrogenase 1
Name Inosine-5'-monophosphate dehydrogenase 1
Gene Name IMPDH1
Pharmacological action yes
Actions inhibitor
References
  • Dzidic A, Prgomet C, Mohr A, Meyer K, Bauer J, Meyer HH, Pfaffl MW: Effects of mycophenolic acid on inosine monophosphate dehydrogenase I and II mRNA expression in white blood cells and various tissues in sheep. J Vet Med A Physiol Pathol Clin Med. 2006 May;53(4):163-9. - Pubmed
DTHybrid score Not Available
Inosine-5'-monophosphate dehydrogenase 2
Name Inosine-5'-monophosphate dehydrogenase 2
Gene Name IMPDH2
Pharmacological action yes
Actions inhibitor
References
  • Vannozzi F, Filipponi F, Di Paolo A, Danesi R, Urbani L, Bocci G, Catalano G, De Simone P, Mosca F, Del Tacca M: An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. Transplant Proc. 2004 Nov;36(9):2787-90. - Pubmed
  • Wang J, Zeevi A, Webber S, Girnita DM, Addonizio L, Selby R, Hutchinson IV, Burckart GJ: A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. Pharmacogenet Genomics. 2007 Apr;17(4):283-90. - Pubmed
  • Penuelas S, Noe V, Morales R, Ciudad CJ: Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH. Med Sci Monit. 2005 Jan;11(1):BR6-12. - Pubmed
  • Yam P, Jensen M, Akkina R, Anderson J, Villacres MC, Wu J, Zaia JA, Yee JK: Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. Mol Ther. 2006 Aug;14(2):236-44. Epub 2006 May 2. - Pubmed
  • Dzidic A, Prgomet C, Mohr A, Meyer K, Bauer J, Meyer HH, Pfaffl MW: Effects of mycophenolic acid on inosine monophosphate dehydrogenase I and II mRNA expression in white blood cells and various tissues in sheep. J Vet Med A Physiol Pathol Clin Med. 2006 May;53(4):163-9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score Not Available

Enzymes


UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Dostalek M, Court MH, Hazarika S, Akhlaghi F: Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos. 2011 Mar;39(3):448-55. Epub 2010 Dec 1. - Pubmed
  • Miles KK, Kessler FK, Smith PC, Ritter JK: Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. Epub 2006 Jun 21. - Pubmed
DTHybrid score 0.2963
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Dostalek M, Court MH, Hazarika S, Akhlaghi F: Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos. 2011 Mar;39(3):448-55. Epub 2010 Dec 1. - Pubmed
  • Picard N, Ratanasavanh D, Premaud A, Le Meur Y, Marquet P: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005 Jan;33(1):139-46. Epub 2004 Oct 6. - Pubmed
DTHybrid score 0.3407
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • Dostalek M, Court MH, Hazarika S, Akhlaghi F: Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos. 2011 Mar;39(3):448-55. Epub 2010 Dec 1. - Pubmed
  • Picard N, Ratanasavanh D, Premaud A, Le Meur Y, Marquet P: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005 Jan;33(1):139-46. Epub 2004 Oct 6. - Pubmed
DTHybrid score 0.2869
UDP-glucuronosyltransferase 1-7
Name UDP-glucuronosyltransferase 1-7
Gene Name Not Available
Actions substrate
References
  • Miles KK, Kessler FK, Smith PC, Ritter JK: Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. Epub 2006 Jun 21. - Pubmed
DTHybrid score Not Available
UDP-glucuronosyltransferase 1-6
Name UDP-glucuronosyltransferase 1-6
Gene Name Not Available
Actions substrate
References
  • Miles KK, Kessler FK, Smith PC, Ritter JK: Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. Epub 2006 Jun 21. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2297 Genome polyprotein Not Available 0.1215
2322 Genome polyprotein Not Available 0.1215
2694 Genome polyprotein Not Available 0.1215
2719 Genome polyprotein Not Available 0.1215
2860 Genome polyprotein Not Available 0.1215
2928 Genome polyprotein Not Available 0.1215
3160 Genome polyprotein Not Available 0.1215
3260 Genome polyprotein Not Available 0.1215
4783 Genome polyprotein Not Available 0.1215
5726 Genome polyprotein Not Available 0.1215
5779 Genome polyprotein Not Available 0.1215
5867 Genome polyprotein Not Available 0.1215
6253 Genome polyprotein Not Available 0.1215
6301 Genome polyprotein Not Available 0.1215
6380 Genome polyprotein Not Available 0.1215
6381 Genome polyprotein Not Available 0.1215
6437 Genome polyprotein Not Available 0.1215
6520 Genome polyprotein Not Available 0.1215
6521 Genome polyprotein Not Available 0.1215
6652 Genome polyprotein Not Available 0.1215
6734 Genome polyprotein Not Available 0.1215
6735 Genome polyprotein Not Available 0.1215
6736 Genome polyprotein Not Available 0.1215
6737 Genome polyprotein Not Available 0.1215
6738 Genome polyprotein Not Available 0.1215
6739 Genome polyprotein Not Available 0.1215
6744 Genome polyprotein Not Available 0.1215
6748 Genome polyprotein Not Available 0.1215
6894 Genome polyprotein Not Available 0.1215
6898 Genome polyprotein Not Available 0.1215
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.1035
4757 Cytochrome P450 2C9 CYP2C9 0.0988
4512 Cytochrome P450 3A4 CYP3A4 0.0938
1588 Multidrug resistance protein 1 ABCB1 0.0871
4924 Cytochrome P450 2C8 CYP2C8 0.0779
20 Prostaglandin G/H synthase 1 PTGS1 0.0741
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0668
587 Serum albumin ALB 0.0666
290 Prostaglandin G/H synthase 2 PTGS2 0.0621
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0586
6016 Cytochrome P450 2C19 CYP2C19 0.058
4118 Cytochrome P450 3A5 CYP3A5 0.058
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0567
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0523
4200 Cytochrome P450 1A2 CYP1A2 0.0481
4604 Liver carboxylesterase 1 CES1 0.0466
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0465
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0447
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0426
752 Large structural protein L 0.0426
1729 Solute carrier family 22 member 6 SLC22A6 0.0384
4119 Cytochrome P450 2D6 CYP2D6 0.038
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0371
3719 Inosine-5'-monophosphate dehydrogenase guaB 0.0353
3799 Hypoxanthine phosphoribosyltransferase hpt 0.0353
3810 Catechol O-methyltransferase COMT 0.0349
6030 Cytochrome P450 2B6 CYP2B6 0.0347
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0345
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0341
6107 Cytochrome P450 3A7 CYP3A7 0.0309
6026 Alcohol dehydrogenase 6 ADH6 0.03
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0299
6021 Adenosine kinase ADK 0.0299
467 Delta-type opioid receptor OPRD1 0.0289
696 Kappa-type opioid receptor OPRK1 0.0288
2164 Multidrug resistance-associated protein 4 ABCC4 0.0286
6171 Solute carrier family 28 member 3 SLC28A3 0.0283
847 Mu-type opioid receptor OPRM1 0.0275
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0253
862 Multidrug resistance-associated protein 1 ABCC1 0.0248
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0245
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0242
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0236
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0236
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0229
5718 Cytochrome P450 2A6 CYP2A6 0.0225
2632 Adenylosuccinate synthetase purA 0.022
3323 Adenylosuccinate synthetase purA 0.022
3975 Adenylosuccinate synthetase ADSS 0.022
4598 Adenylosuccinate synthetase Adss 0.022
6817 Adenylosuccinate synthetase purA 0.022
6102 Arylamine N-acetyltransferase 2 NAT2 0.0205
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0198
6024 Cytochrome P450 1A1 CYP1A1 0.019
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0174
32 Vascular endothelial growth factor receptor 1 FLT1 0.0167
3866 Serum amyloid A protein SAA1 0.0163
1200 AMBP protein AMBP 0.0163
1932 Apolipoprotein E APOE 0.0163
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0162
1152 Glycogen phosphorylase, muscle form PYGM 0.0157
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0157
723 Cytosolic phospholipase A2 PLA2G4A 0.0156
3233 Bile acid receptor NR1H4 0.0156
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0154
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0153
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0152
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0146
504 Mast/stem cell growth factor receptor KIT 0.0146
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
6142 Solute carrier family 22 member 8 SLC22A8 0.0138
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0136
407 Vascular endothelial growth factor receptor 2 KDR 0.0134
1024 Solute carrier family 22 member 11 SLC22A11 0.0132
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0127
6013 Cytochrome P450 2E1 CYP2E1 0.0126
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0121
5880 Thrombopoietin receptor MPL 0.012
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0115
6106 Cytochrome P450 2C18 CYP2C18 0.0113
228 Beta platelet-derived growth factor receptor PDGFRB 0.0109
54 Prothrombin F2 0.0108
738 Monocarboxylate transporter 1 SLC16A1 0.0107
275 Arachidonate 5-lipoxygenase ALOX5 0.0106
4132 Chloride channel protein ClC-Ka CLCNKA 0.0104
146 Androgen receptor AR 0.0104
1760 Aminopeptidase N ANPEP 0.0101
6843 Aminopeptidase N pepN 0.0101
117 Sterol O-acyltransferase 1 SOAT1 0.0099
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0098
817 DNA topoisomerase 2-alpha TOP2A 0.0096
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0095
319 Opioid receptor, sigma 1 OPRS1 0.0094
2021 Thrombomodulin THBD 0.0094
6143 Solute carrier family 22 member 7 SLC22A7 0.0094
459 Retinoic acid receptor RXR-alpha RXRA 0.0094
6138 Multidrug resistance protein 3 ABCB4 0.0093
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0089
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0088
267 Plasminogen activator inhibitor 1 SERPINE1 0.0086
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0083
2981 Phospholipase A2, membrane associated PLA2G2A 0.0082
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0081
6221 Steroid hormone receptor ERR1 ESRRA 0.008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0079
1630 Integrin beta-2 ITGB2 0.0078
6085 Fatty acid-binding protein, intestinal FABP2 0.0076
6103 Arylamine N-acetyltransferase 1 NAT1 0.0076
766 Beta-2 adrenergic receptor ADRB2 0.0075
6141 Sodium/bile acid cotransporter SLC10A1 0.0075
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0074
341 5-hydroxytryptamine 3 receptor HTR3A 0.0074
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0073
6042 Prostaglandin reductase 2 PTGR2 0.0071
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0069
1757 Myeloperoxidase MPO 0.0069
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0069
6137 Multidrug resistance-associated protein 6 ABCC6 0.0068
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0067
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0067
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0066
1898 Cytochrome P450 1B1 CYP1B1 0.0066
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0066
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0066
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0066
1792 Tissue-type plasminogen activator PLAT 0.0065
6043 Putative G-protein coupled receptor 44 GPR44 0.0065
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0064
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0064
824 Sodium-dependent serotonin transporter SLC6A4 0.0064
3809 Estrogen-related receptor gamma ESRRG 0.0064
273 Apoptosis regulator Bcl-2 BCL2 0.0064
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0063
6500 Phospholipase A2 PLA2G1B 0.0063
6044 Serum paraoxonase/lactonase 3 PON3 0.0063
489 Monocarboxylate transporter 2 SLC16A7 0.0062
5798 Mitogen-activated protein kinase 11 MAPK11 0.0061
816 Biliverdin reductase A BLVRA 0.0059
572 Integrin alpha-L ITGAL 0.0059
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0059
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0059
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0059
1353 DNA topoisomerase 1 TOP1 0.0059
3552 DNA topoisomerase 1 topA 0.0059
1192 Sulfotransferase 1A1 SULT1A1 0.0058
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0057
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0057
70 Type-1 angiotensin II receptor AGTR1 0.0056
1275 Estrogen sulfotransferase SULT1E1 0.0056
1039 Histone deacetylase 9 HDAC9 0.0055
789 Alpha-1D adrenergic receptor ADRA1D 0.0055
1313 Lactoylglutathione lyase GLO1 0.0054
776 Bile salt export pump ABCB11 0.0054
4122 Histone deacetylase 2 HDAC2 0.0054
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0054
1050 Bile salt sulfotransferase SULT2A1 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0053
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0053
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0053
646 Malate dehydrogenase, cytoplasmic MDH1 0.0053
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0053
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0053
328 Sorbitol dehydrogenase SORD 0.0052
597 Dihydropteridine reductase QDPR 0.0052
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0052
396 Alcohol dehydrogenase 4 ADH4 0.0052
6147 Solute carrier family 22 member 3 SLC22A3 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
811 Translocator protein TSPO 0.0051
6031 Cytochrome P450 3A43 CYP3A43 0.005
632 Alpha-1B adrenergic receptor ADRA1B 0.0049
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0049
891 Dihydropteroate synthase folP 0.0049
5359 Dihydropteroate synthase folP 0.0049
7175 Dihydropteroate synthase sulI 0.0049
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0049
12 Alcohol dehydrogenase class 3 ADH5 0.0048
77 L-lactate dehydrogenase B chain LDHB 0.0048
3937 Fatty-acid amide hydrolase FAAH 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0047
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0047
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0047
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0047
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
936 Ephrin type-A receptor 2 EPHA2 0.0046
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0046
473 L-lactate dehydrogenase A chain LDHA 0.0046
5787 Angiopoietin-1 receptor TEK 0.0046
1618 High affinity nerve growth factor receptor NTRK1 0.0046
165 FL cytokine receptor FLT3 0.0046
6220 Aryl hydrocarbon receptor AHR 0.0045
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0045
823 Fibroblast growth factor receptor 2 FGFR2 0.0044
556 Alpha-1A adrenergic receptor ADRA1A 0.0044
569 Retinal dehydrogenase 2 ALDH1A2 0.0044
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0043
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0043
4692 A/G-specific adenine glycosylase mutY 0.0043
3811 Cytochrome P450 19A1 CYP19A1 0.0042
611 Retinal dehydrogenase 1 ALDH1A1 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0042
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0041
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0041
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0041
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0041
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0041
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0041
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0041
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0041
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0041
251 Alcohol dehydrogenase 1A ADH1A 0.0041
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0041
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0041
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0041
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0041
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0041
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0041
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0041
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0041
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0041
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0041
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0041
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0041
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0041
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0041
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0041
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0041
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0041
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0041
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0041
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0041
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0041
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0041
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0041
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0041
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0041
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0041
206 3-keto-steroid reductase HSD17B7 0.0041
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0041
107 C-4 methylsterol oxidase SC4MOL 0.0041
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0041
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0041
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0041
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0041
644 Heme oxygenase 2 HMOX2 0.0041
4982 Heme oxygenase 2 pbsA2 0.0041
729 GDP-L-fucose synthetase TSTA3 0.0041
3463 GDP-L-fucose synthetase fcl 0.0041
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0041
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0041
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0041
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0041
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0041
3726 D-3-phosphoglycerate dehydrogenase serA 0.0041
4291 D-3-phosphoglycerate dehydrogenase serA 0.0041
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0041
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0041
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0041
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0041
167 L-lactate dehydrogenase C chain LDHC 0.0041
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0041
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0041
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0041
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0041
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0041
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0041
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0041
34 7-dehydrocholesterol reductase DHCR7 0.0041
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0041
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0041
711 UDP-glucose 6-dehydrogenase UGDH 0.0041
3672 UDP-glucose 6-dehydrogenase hasB 0.0041
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0041
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0041
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0041
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0041
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0041
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0041
643 Peroxisomal bifunctional enzyme EHHADH 0.0041
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0041
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
6145 Solute carrier family 22 member 1 SLC22A1 0.004
4217 Telomerase reverse transcriptase TERT 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0038
444 Alcohol dehydrogenase 1B ADH1B 0.0037
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
468 Cytochrome P450 4A11 CYP4A11 0.0036
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0036
666 NADP-dependent malic enzyme ME1 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
3923 Cholinesterase BCHE 0.0036
857 Malate dehydrogenase, mitochondrial MDH2 0.0035
714 Glutathione reductase, mitochondrial GSR 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0035
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0035
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0035
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0034
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0034
517 Alcohol dehydrogenase 1C ADH1C 0.0033
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0033
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0033
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0033
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0033
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0033
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
844 Epidermal growth factor receptor EGFR 0.0032
627 11-cis retinol dehydrogenase RDH5 0.0032
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0032
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0032
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0032
626 Cysteine dioxygenase type 1 CDO1 0.0032
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0032
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0032
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0032
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0032
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0032
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0032
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0032
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0032
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0032
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0032
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0031
6148 Multidrug resistance-associated protein 7 ABCC10 0.0031
13 Aminomethyltransferase, mitochondrial AMT 0.0031
2320 Thymidine kinase, cytosolic TK1 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0031
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0031
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0031
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.003
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.003
952 Dipeptidyl peptidase 4 DPP4 0.0029
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0029
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0029
654 Flavin reductase BLVRB 0.0028
279 Tyrosinase TYR 0.0027
6144 Solute carrier family 22 member 2 SLC22A2 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
810 Heme oxygenase 1 HMOX1 0.0026
3391 Heme oxygenase 1 pbsA1 0.0026
118 Organic cation/carnitine transporter 2 SLC22A5 0.0025
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0025
760 Fibroblast growth factor 1 FGF1 0.0025
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0025
380 Cytochrome P450 17A1 CYP17A1 0.0025
373 Transthyretin TTR 0.0024
4192 DNA topoisomerase 2-beta TOP2B 0.0024
638 D(3) dopamine receptor DRD3 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0023
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0023
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0023
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0023
4428 Redox-sensing transcriptional repressor rex rex 0.0023
4449 ADP-ribosyltransferase Not Available 0.0023
4414 Dehydrogenase TT_P0035 0.0023
2350 3-isopropylmalate dehydrogenase leuB 0.0023
3092 3-isopropylmalate dehydrogenase leuB 0.0023
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0023
4497 Benzyl alcohol dehydrogenase xylB 0.0023
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0023
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0023
4472 Glucose 1-dehydrogenase Not Available 0.0023
4423 Levodione reductase lvr 0.0023
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0023
4443 Quinate/shikimate dehydrogenase ydiB 0.0023
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0023
4502 Formate dehydrogenase Not Available 0.0023
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0023
4500 L-lactate dehydrogenase 2 ldh2 0.0023
4447 Hypothetical protein yhfP yhfP 0.0023
3381 Alcohol dehydrogenase Not Available 0.0023
4508 Alcohol dehydrogenase adhA 0.0023
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0023
4418 AGR_L_3209p AGR_L_3209 0.0023
4507 Alanine dehydrogenase ald 0.0023
4455 Glycerol dehydrogenase gldA 0.0023
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0023
4487 Transcriptional regulator nadR nadR 0.0023
3729 Citrate synthase gltA 0.0023
4575 Citrate synthase cit 0.0023
4580 Citrate synthase gltA 0.0023
4435 L-aspartate dehydrogenase nadX 0.0023
4451 Vip2Ac vip2Ac 0.0023
4467 Alpha-glucosidase, putative TM_0752 0.0023
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0023
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0022
23 D(1A) dopamine receptor DRD1 0.0022
6020 Aldehyde oxidase AOX1 0.0021
822 Aldose reductase AKR1B1 0.0021
502 5-hydroxytryptamine 2A receptor HTR2A 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
831 D(2) dopamine receptor DRD2 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
3947 Xanthine dehydrogenase/oxidase XDH 0.0019
4486 Phenol 2-hydroxylase component B pheA2 0.0019
4439 Ferredoxin reductase bphA4 0.0019
4477 Dihydrolipoyl dehydrogenase lpdV 0.0019
5077 Dihydrolipoyl dehydrogenase Not Available 0.0019
5117 Dihydrolipoyl dehydrogenase lpd 0.0019
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0019
4503 NADPH-flavin oxidoreductase frp 0.0019
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0019
904 Glutathione S-transferase P GSTP1 0.0019
4427 TDP-glucose-4,6-dehydratase desIV 0.0019
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0019
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0019
2967 CDP-paratose 2-epimerase rfbE 0.0018
4482 UDP-galactose 4-epimerase galE 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0018
5773 DNA-directed RNA polymerase beta chain rpoB 0.0018
2507 Diphtheria toxin Not Available 0.0018
2538 6-phospho-beta-glucosidase bglT bglT 0.0018
2393 Maltose-6'-phosphate glucosidase glvA 0.0018
3081 3-dehydroquinate synthase aroB 0.0018
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0018
4450 Iota toxin component Ia Not Available 0.0018
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0018
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0018
4509 Acetoin(diacetyl) reductase budC 0.0018
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0018
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0018
2591 Urocanate hydratase hutU 0.0018
4498 Ornithine cyclodeaminase PP3533 0.0018
3615 Dihydrodipicolinate reductase dapB 0.0018
3618 Dihydrodipicolinate reductase dapB 0.0018
4462 Dihydrodipicolinate reductase dapB 0.0018
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0018
2424 L-lactate dehydrogenase ldh 0.0018
2641 L-lactate dehydrogenase Not Available 0.0018
4437 L-lactate dehydrogenase ldh 0.0018
4442 L-lactate dehydrogenase ldh 0.0018
2336 2,3-diketo-L-gulonate reductase dlgD 0.0018
126 D-lactate dehydrogenase dld 0.0018
3545 D-lactate dehydrogenase Not Available 0.0018
4510 D-lactate dehydrogenase ldhA 0.0018
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0018
4496 C-terminal-binding protein 1 CTBP1 0.0018
2018 Deoxyhypusine synthase DHPS 0.0018
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0018
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0018
2683 Mono-ADP-ribosyltransferase C3 C3 0.0017
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0017
4504 WbpP Not Available 0.0017
4440 NADH peroxidase npr 0.0017
3367 GDP-mannose 6-dehydrogenase algD 0.0017
4318 Siroheme synthase cysG 0.0017
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0017
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0016
4343 Alpha-glucosidase aglA 0.0016
63 Malate dehydrogenase mdh 0.0016
2329 Malate dehydrogenase mdh 0.0016
3445 Malate dehydrogenase mdh 0.0016
4420 Malate dehydrogenase mdh 0.0016
4438 Malate dehydrogenase mdh 0.0016
4476 Mannitol dehydrogenase mtlD 0.0016
2617 Nitric oxide synthase oxygenase nos 0.0016
2701 Nitric oxide synthase oxygenase nos 0.0016
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0016
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0016
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0016
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0016
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0016
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0016
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0016
3070 Adenosylhomocysteinase AHCY 0.0016
4424 Adenosylhomocysteinase PFE1050w 0.0016
6278 Adenosylhomocysteinase ahcY 0.0016
2826 Glucose--fructose oxidoreductase gfo 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
3191 Histidinol dehydrogenase hisD 0.0015
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0015
4491 DNA ligase, NAD-dependent ligA 0.0014
2286 Isocitrate dehydrogenase [NADP] icd 0.0014
2302 Isocitrate dehydrogenase [NADP] icd 0.0014
2771 Isocitrate dehydrogenase [NADP] icd 0.0014
2762 UDP-glucose 4-epimerase GALE 0.0014
3461 UDP-glucose 4-epimerase galE 0.0014
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
869 Estrogen receptor beta ESR2 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
136 Estrogen receptor ESR1 0.001
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