| Name |
Large structural protein |
| Synonyms |
2202 |
| Gene name |
L |
| General function |
Involved in RNA binding |
| Specific function |
Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-7-N-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The transcriptase stutters on a specific sequence, resulting on a cotranscriptional editing of the phosphoprotein (P) mRNA. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals |
| Gene sequence |
+ ...
ATGGCGGCCTCTTCTGAGATACTCCTTCCTGAAGTCCACTTGAACTCACCAATAGTCAAACACAAACTCATATACTACTTATTACTAGGGCACTTCCCGCATGATCTTGACATTTCTGAAATAAGCCCCCTTCACAATAATGATTGGGATCAAATTGCCAGAGAAGAATCCAATCTTGCTGAACGACTTGGAGTAGCTAAATCTGAATTAATTAAACGTGTGCCCGCATTTAGAGCAACTAGATGGCGTAGTCATGCAGCCGTCCTTATATGGCCTTCTTGTATACCATTTCTTGTTAAATTCCTACCTCATTCTAAGCTTCAACCAGTAGAACAATGGTACAAGTTGATCAATGCTTCATGTAATACTATATCTGACTCAATTGATAGATGTATGGAGAATATTTCTATTAAGCTTACTGGGAAAAACAATCTATTCTCTCGATCCAGAGGAACTGCAGGTGCAGGTAAAAACAGTAAAATCACCCTCAATGATATCCAATCTATTTGGGAATCAAACAAGTGGCAACCTAATGTATCTTTATGGCTTACAATTAAATACCAAATGCGACAACTTATAATGCATCAAAGTTCTCGTCAGCCGACTGATTTAGTTCACATTGTTGACACACGATCTGGTCTAATAGTTATCACCCCTGAACTTGTTATTTGTTTTGATCGGTTAAATAGTGTTTTAATGTATTTTACATTTGAGATGACTTTAATGGTAAGTGACATGTTTGAGGGAAGGATGAATGTCACCGCTCTCTGCACTATTAGTCATTACTTATCTCCACTAGGGCCAAGGATAGATAGATTGTTTTCCATTGTAGATGAATTAGCACAACTATTAGGTGACACTGTATATAAAGTTATTGCATCTCTTGAATCTTTAGTATATGGGTGTCTACAACTTAAAGATCCAGTAGTGGAATTAGCAGGGTCATTTCATTCCTTTATTACACAAGAGATTATAGATATCCTAATTGGTTCAAAAGCCCTTGATAAGGATGAATCAATAACTGTTACTACACAATTGTTAGATATATTTTCCAACCTTTCTCCAGATTTAATTGCTGAGATGTTGTGTCTCATGAGACTTTGGGGTCATCCCACTCTTACTGCTGCGCAAGTGGGTAAAGTGAGAGAATCTATGTGTGCAGGTAAGTTACTTGATTTCCCTACAATAATGAAAACTCTTGCTTTTTTCCACACAATTTTAATTAATGGTTACCGTAGAAAGAAAAATGGAATGTGGCCTCCACTTATACTTCCTAAAAATGCATCAAAAAGCTTAATAGAATTTCAACATGATAATGCTGAAATATCTTACGAATATACACTCAAGCATTGGAAAGAGATATCTCTCATAGAATTTAGAAAGTGCTTTGACTTTGATCCTGGTGAGGAGCTAAGCATTTTTATGAAAGACAAGGCAATAAGTGCTCCAAGAAGTGATTGGATGAGTGTATTTCGTAGAAGTCTAATAAAACAACGACATCAGAGACATCATATTCCTATGCCCAATCCATTTAATAGACGTCTATTACTCAATTTCTTAGAAGATGACAGTTTTGATCCAGTTGCCGAGCTTCGATATGTTACCGGTGGTGAATATCTCCAAGATGACACATTTTGTGCATCTTACTCATTAAAAGAGAAAGAAATAAAACCAGATGGAAGGATATTTGCTAAGCTTACTAATAGAATGCGGTCCTGTCAAGTAATTGCGGAAGCAATTCTCGCAAATCATGCAGGTACTCTAATGAAGGAAAACGGAGTTGTCTTGAATCAATTATCACTGACTAAATCATTGCTTACTATGAGTCAAATTGGCATAATATCAGAAAAGGCGAAGAGATATACGCGAGATAACATCTCATCCCAAGGTTTCCATACAATCAAGACTGATTCTAAAAATAAGAGGAAAAGCAAAACTGCATCATCATACCTCACAGATCCTGATGATACATTTGAACTTAGTGCATGTTTTATAACTACTGATCTTGCTAAATACTGTCTTCAATGGAGATATCAGACCATAATCCATTTTGCTCGAACATTAAACAGAATGTATGGAGTTCCACATTTATTTGAATGGATTCATCTTCGTTTAATTAGATCTACATTATATGTTGGTGATCCATTCAATCCTCCTGCCGCAACTGATGCTTTCGATCTAGATAAAGTATTAAATGGTGATATCTTTATAGTCTCCAAGGGAGGTATTGAAGGCCTATGTCAGAAAATGTGGACAATGATCTCTATTTCTGTGATCATCCTCTCTTCAGCCGAATCCAAAACAAGAGTAATGAGCATGGTTCAAGGAGATAATCAGGCGATTGCAGTTACAACAAGAGTTCCTAGATCATTACCTAGTATTCAGAAAAAGGAGTTAGCCTATGCAGCAAGCAAGTTATTTTTTGAAAGACTTAGGGCAAATAATTATGGGTTGGGTCATCAGCTAAAGGCTCAAGAAACTATAATAAGTTCCACGTTCTTCATATATAGTAAACGGGTATTTTATCAAGGACGTATACTAACACAGGCACTCAAAAATGCTAGCAAGTTATGTCTTACTGCAGATGTATTAGGTGAATGTACTCAAGCTTCCTGTTCAAATTCTGCTACTACCATCATGAGATTAACAGAAAATGGGGTTGAGAAAGATACATGTTATAAGCTTAATATTTATCAGTCCATTCGTCAACTCACATATGATCTAATATTTCCCCAATACTCCATACCAGGTGAAACTATAAGTGAGATTTTCCTACAGCATCCAAGACTAATCTCACGTATTGTTCTGCTCCCTTCACAGCTAGGTGGTCTTAATTACCTCGCATGTAGCAGATTATTTAACCGCAATATCGGAGATCCTCTTGGTACAGCTGTGGCAGATCTCAAGAGGTTAATTAAATGTGGTGCTCTTGAATCATGGATACTGTATAATTTACTAGCAAGAAAACCAGGGAAAGGTTCATGGGCAACTTTAGCAGCCGATCCATACTCATTGAATCAAGAATATCTTTATCCTCCTACTACTATACTTAAAAGACATACTCAAAATACTTTAATGGAGATATGTCGGAATCCTATGTTAAAGGGAGTTTTTACAGATAATGCAAAAGAGGAGGAAAATCTCCTTGCAAAATTTCTTCTTGATCGTGATATAGTATTGCCAAGAGTTGCACACATTATAATAGATCAATCTAGCATCGGAAGGAAGAAACAGATACAAGGATTTTTTGACACCACAAGGACCATAATGAGACGATCATTTGAAATCAAACCACTCTCAACTAAGAAGACTCTTTCAGTCATAGAATATAATACTAATTACTTATCTTATAACTACCCTGTCATACTTAATCCTTTACCTATTCCTGGATATTTAAATTATATTACTGACCAAACTTGCAGTATTGATATATCTAGAAGTTTAAGAAAATTATCATGGTCTTCTTTATTGAATGGAAGAACTTTAGAAGGATTAGAAACTCCAGATCCAATTGAAGTTGTCAATGGTTTCTTGATTGTAGGTACAGGAGATTGTGATTTTTGTATGCAGGGTGACGACAAATTTACTTGGTTCTTTTTACCTATGGGGATAATTATTGATGGAAATCCTGAAACTAATCCACCCATCAGAGTTCCATACATTGGGTCTAGAACAGAGGAAAGAAGAGTTGCATCAATGGCATATATTAAAGGTGCCACACACAGTTTGAAGGCTGCTCTTAGAGGCGCAGGGGTATATATTTGGGCATTCGGGGATACTGTAGTGAACTGGAATGATGCACTTGATATCGCAAATACTAGGGTTAAGATATCCCTAGAGCAACTTCAGACCCTTACACCTCTTCCTACATCTGCAAACATTACACACCGTTTAGATGATGGAGCCACAACACTTAAATTCACTCCAGCTAGTTCCTATGCATTTTCTAGTTATACTCATATATCAAATGATCAACAATATTTAGAAATAGATCAGAGAGTAGTCGATTCTAATATTATTTATCAACAATTAATGATAACAGGACTTGGGATTATTGAGACCTACCATAACCCACCTATAAGGACTTCTACACAAGAAATCACTCTCCATTTGCACACTAGCTCATCTTGTTGTGTTAGAAGTGTAGATGGTTGCCTTATATGTGAGAGCAATGGAGAGGTTCCTCAGATCACTGTTCCCTATACTAATACATTTGTATATGATCCTGATCCACTAGCAGATTATGAGATTGCACACCTAGATTATCTCTCCTACCAAGCTAAAATTGGAAGTACAGATTACTACTCACTCACTGATAAAATTGACCTATTAGCACATTTAACTGCAAAACAAATGATAAACTCAATAATTGGGTTAGATGAAACAGTATCAATTGTCAATGATGCGGTTATCCTATCTGACTATACTAATAACTGGATTAGTGAATGTTCTTATACTAAGATAGATTTAGTTTTTAAATTAATGGCATGGAATTTCCTTCTTGAGCTTGCATTCCAGATGTACTACTTAAGGATATCATCTTGGACAAATATATTTGACTATACTTATATGACTTTGCGCAGGATACCCGGAACTGCTCTAAATAATATTGCAGCTACTATTAGCCATCCAAAATTATTAAGACGTGCAATGAATCTTGATATTATCACTCCTATACATGCACCGTATTTAGCTTCATTAGATTATGTCAAATTAAGTATTGATGCAATTCAGTGGGGAGTTAAACAAGTTCTTGCTGATTTATCAAATGGAATTGATCTTGAAATCTTGATTCTTTCAGAGGATTCAATGGAAATTAGTGATAGGGCAATGAATCTCATTGCTAGAAAACTAACTCTCCTTGCACTTGTTAAAGGTGAGAACTATACTTTTCCAAAAATTAAAGGGATGCCACCAGAAGAAAAGTGTTTAGTCTTAACTGAATATCTAGCAATGTGTTATCAAAATACTCATCACTTAGATCCAGATCTTCAAAAGTATTTATATAATCTAACTAATCCAAAATTGACTGCATTTCCCAGTAACAACTTCTACTTAACTAGAAAAATCCTTAATCAAATTAGAGAATCAGACGAAGGACAATATATTATCACCTCATATTATGAATCCTTCGAACAATTAGAAACAGATATAATTCTTCACTCTACTTTAACTGCTCCTTATGATAATTCAGAAAACTCTAACAAAGTTCGATTTATCCCTTTCGACATCTTTCCACATCCAGAATCTCTCGAGAAATATCCTCTTCCAGTTGATCATGACTCTCAATCTGCAATTTCAACACTAATTCCAGGCCCTCCTTCTCATCATGTATTACGACCACTAGGAGTGTCATCCACAGCTTGGTATAAAGGGATAAGTTATTGTAGATACCTAGAAACACAAAAGATACAGACTGGTGATCATCTTTATTTAGCCGAAGGAAGCGGTGCTTCAATGTCACTTCTAGAACTCTTATTTCCAGGAGATACTGTCTATTATAATAGTCTTTTTAGTAGTGGAGAGAATCCTCCACAGAGAAACTATGCCCCTCTTCCAACTCAATTTGTACAGAGTGTTCCATATAAATTGTGGCAAGCTGATCTTGCTGATGATAGCAATTTGATAAAAGATTTTGTCCCATTATGGAATGGAAACGGTGCAGTTACAGACTTATCAACAAAGGATGCAGTTGCATTCATAATACATAAAGTAGGAGCAGAGAAAGCATCCCTTGTCCATATAGATCTCGAATCAACTGCTAATATAAATCAGCAAACTCTGTCCAGATCCCAGATTCATTCATTAATTATAGCAACTACTGTTCTTAAGAGGGGTGGGATATTAATTTATAAAACATCATGGCTTCCGTTTTCTAGGTTTAGTCAACTAGCAGGTCTACTTTGGTGCTTCTTTGACCGGATCCATCTAATACGTAGTAGCTATTCTGATCCTCACAGTCATGAGGTTTATCTTGTATGTAGACTTGCCGCAGATTTTAGAACTATCGGTTTCAGTGCAGCTCTAGTAACTGCTACTACTCTTCACAATGACGGATTCACAACAATACATCCTGATGTTGTTTGTAGTTATTGGCAACACCATCTTGAAAATGTTGGGAGAGTCGGAAAAGTAATTGATGAGATACTTGATGGTTTAGCCACCAACTTCTTCGCAGGAGATAATGGGCTTATTCTAAGATGTGGAGGAACTCCAAGCTCCAGAAAATGGTTAGAGATTGACCAGTTAGCATCATTTGATTTGGTTCAAGATGCTCTGGTTACACTTATCACTATACACCTAAAGGAAATTATAGAAGTGCAGTCATCACATACAGAGGATTATACATCTCTCCTCTTCACACCTTATAATATTGGTGCAGCAGGGAAAGTCAGAACTATCATCAAATTAATTCTAGAACGATCTTTAATGTATACAGTCCGAAATTGGTTAGTTTTACCCAGTTCCATCCGGGATTCTGTACGACAAGATTTAGAATTAGGGTCATTTAGATTAATGTCTATTTTAAGTGAACAGACATTTCTTAAAAAGACACCCACAAAAAAATACTTACTTGATCAGCTTACAAGGACATATATATCAACCTTCTTTAACTCTCACTCAGTCCTTCCCCTCCACCGTCCATATCAAAAACAAATATGGAAAGCCTTAGGTAGTGTAATATATTGTTCGGAGACAGTTGATATACCTCTAATTAAAGACATTCAGATAGAAGATATTAATGATTTTGAAGATATCGAGAGGGGTATCGATGGCGAAGAATTATGA
|
| Protein sequence |
+ ...
MAASSEILLPEVHLNSPIVKHKLIYYLLLGHFPHDLDISEISPLHNNDWDQIAREESNLAERLGVAKSELIKRVPAFRATRWRSHAAVLIWPSCIPFLVKFLPHSKLQPVEQWYKLINASCNTISDSIDRCMENISIKLTGKNNLFSRSRGTAGAGKNSKITLNDIQSIWESNKWQPNVSLWLTIKYQMRQLIMHQSSRQPTDLVHIVDTRSGLIVITPELVICFDRLNSVLMYFTFEMTLMVSDMFEGRMNVTALCTISHYLSPLGPRIDRLFSIVDELAQLLGDTVYKVIASLESLVYGCLQLKDPVVELAGSFHSFITQEIIDILIGSKALDKDESITVTTQLLDIFSNLSPDLIAEMLCLMRLWGHPTLTAAQVGKVRESMCAGKLLDFPTIMKTLAFFHTILINGYRRKKNGMWPPLILPKNASKSLIEFQHDNAEISYEYTLKHWKEISLIEFRKCFDFDPGEELSIFMKDKAISAPRSDWMSVFRRSLIKQRHQRHHIPMPNPFNRRLLLNFLEDDSFDPVAELRYVTGGEYLQDDTFCASYSLKEKEIKPDGRIFAKLTNRMRSCQVIAEAILANHAGTLMKENGVVLNQLSLTKSLLTMSQIGIISEKAKRYTRDNISSQGFHTIKTDSKNKRKSKTASSYLTDPDDTFELSACFITTDLAKYCLQWRYQTIIHFARTLNRMYGVPHLFEWIHLRLIRSTLYVGDPFNPPAATDAFDLDKVLNGDIFIVSKGGIEGLCQKMWTMISISVIILSSAESKTRVMSMVQGDNQAIAVTTRVPRSLPSIQKKELAYAASKLFFERLRANNYGLGHQLKAQETIISSTFFIYSKRVFYQGRILTQALKNASKLCLTADVLGECTQASCSNSATTIMRLTENGVEKDTCYKLNIYQSIRQLTYDLIFPQYSIPGETISEIFLQHPRLISRIVLLPSQLGGLNYLACSRLFNRNIGDPLGTAVADLKRLIKCGALESWILYNLLARKPGKGSWATLAADPYSLNQEYLYPPTTILKRHTQNTLMEICRNPMLKGVFTDNAKEEENLLAKFLLDRDIVLPRVAHIIIDQSSIGRKKQIQGFFDTTRTIMRRSFEIKPLSTKKTLSVIEYNTNYLSYNYPVILNPLPIPGYLNYITDQTCSIDISRSLRKLSWSSLLNGRTLEGLETPDPIEVVNGFLIVGTGDCDFCMQGDDKFTWFFLPMGIIIDGNPETNPPIRVPYIGSRTEERRVASMAYIKGATHSLKAALRGAGVYIWAFGDTVVNWNDALDIANTRVKISLEQLQTLTPLPTSANITHRLDDGATTLKFTPASSYAFSSYTHISNDQQYLEIDQRVVDSNIIYQQLMITGLGIIETYHNPPIRTSTQEITLHLHTSSSCCVRSVDGCLICESNGEVPQITVPYTNTFVYDPDPLADYEIAHLDYLSYQAKIGSTDYYSLTDKIDLLAHLTAKQMINSIIGLDETVSIVNDAVILSDYTNNWISECSYTKIDLVFKLMAWNFLLELAFQMYYLRISSWTNIFDYTYMTLRRIPGTALNNIAATISHPKLLRRAMNLDIITPIHAPYLASLDYVKLSIDAIQWGVKQVLADLSNGIDLEILILSEDSMEISDRAMNLIARKLTLLALVKGENYTFPKIKGMPPEEKCLVLTEYLAMCYQNTHHLDPDLQKYLYNLTNPKLTAFPSNNFYLTRKILNQIRESDEGQYIITSYYESFEQLETDIILHSTLTAPYDNSENSNKVRFIPFDIFPHPESLEKYPLPVDHDSQSAISTLIPGPPSHHVLRPLGVSSTAWYKGISYCRYLETQKIQTGDHLYLAEGSGASMSLLELLFPGDTVYYNSLFSSGENPPQRNYAPLPTQFVQSVPYKLWQADLADDSNLIKDFVPLWNGNGAVTDLSTKDAVAFIIHKVGAEKASLVHIDLESTANINQQTLSRSQIHSLIIATTVLKRGGILIYKTSWLPFSRFSQLAGLLWCFFDRIHLIRSSYSDPHSHEVYLVCRLAADFRTIGFSAALVTATTLHNDGFTTIHPDVVCSYWQHHLENVGRVGKVIDEILDGLATNFFAGDNGLILRCGGTPSSRKWLEIDQLASFDLVQDALVTLITIHLKEIIEVQSSHTEDYTSLLFTPYNIGAAGKVRTIIKLILERSLMYTVRNWLVLPSSIRDSVRQDLELGSFRLMSILSEQTFLKKTPTKKYLLDQLTRTYISTFFNSHSVLPLHRPYQKQIWKALGSVIYCSETVDIPLIKDIQIEDINDFEDIERGIDGEEL
|
| GO Classification |
| function |
| RNA binding |
| nucleotidyltransferase activity |
| RNA-directed RNA polymerase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleic acid binding |
| process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| transcription |
| physiological process |
| metabolism |
| cellular metabolism |
|
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