DT-Web

DB04485 - Deoxythymidine


Identification
Name Deoxythymidine
Accession Number DB04485 (EXPT03053)
Type small molecule
Description Deoxythymidine is a pyrimidine deoxynucleoside. Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 242.2286
Groups experimental
Monoisotopic Weight 242.090271568
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.589
Thymidine kinase 2, mitochondrial
Name Thymidine kinase 2, mitochondrial
Gene Name TK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Glucose-1-phosphate thymidylyltransferase
Name Glucose-1-phosphate thymidylyltransferase
Gene Name rmlA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.0704
Nucleoside-specific channel-forming protein tsx precursor
Name Nucleoside-specific channel-forming protein tsx precursor
Gene Name tsx
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8669
Thymidylate kinase
Name Thymidylate kinase
Gene Name tmk
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0301
Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.589
Uridine phosphorylase
Name Uridine phosphorylase
Gene Name udp
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6457

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
DTHybrid score 0.3264
Solute carrier family 28 member 3
Name Solute carrier family 28 member 3
Gene Name SLC28A3
Actions Not Available
References
  • Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM: Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005;5(3):157-65. - Pubmed
DTHybrid score 0.4101

Predictions


Id Partner name Gene Name Score
5132 Uridine phosphorylase udp 1.6457
509 Thymidine kinase TK 1.589
570 Thymidine kinase TK 1.589
3430 Thymidine kinase tdk 1.589
5301 Thymidine kinase tdk 1.589
5771 Thymidine kinase ORF36 1.589
7009 Thymidine kinase ORF36 1.589
2254 Thymidylate kinase DTYMK 1.0301
3522 Thymidylate kinase tmk 1.0301
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.3302
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.1544
4225 Uridine phosphorylase 1 UPP1 0.1068
277 Purine nucleoside phosphorylase PNP 0.0888
2870 Purine nucleoside phosphorylase punA 0.0888
2945 Purine nucleoside phosphorylase punA 0.0888
4659 Purine nucleoside phosphorylase TM_1596 0.0888
4825 Purine nucleoside phosphorylase TTHA1435 0.0888
4275 PCZA361.16 Not Available 0.0845
4276 DNA polymerase III subunit epsilon dnaQ 0.0844
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.0797
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0795
4773 Deoxycytidine kinase DCK 0.0762
1353 DNA topoisomerase 1 TOP1 0.0755
3552 DNA topoisomerase 1 topA 0.0755
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0704
3101 Glucose-1-phosphatase agp 0.0685
6144 Solute carrier family 22 member 2 SLC22A2 0.0681
3299 DNA primase/helicase 4 0.0677
603 DNA polymerase alpha catalytic subunit POLA1 0.0634
3244 Ribonucleoside-diphosphate reductase 2 alpha subunit nrdE 0.0625
4427 TDP-glucose-4,6-dehydratase desIV 0.0618
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0617
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0617
3028 dTDP-4-dehydrorhamnose 3,5-epimerase rfbC 0.061
4294 DTDP-4-dehydrorhamnose 3,5-epimerase rmlC 0.061
5127 DTDP-4-dehydrorhamnose 3,5-epimerase rmlC 0.061
24 Thymidylate synthase TMP1 0.0609
359 Thymidylate synthase TYMS 0.0609
2626 Thymidylate synthase thyA 0.0609
2729 Thymidylate synthase thyA 0.0609
5352 Thymidylate synthase THYA 0.0609
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0589
3091 Maltodextrin phosphorylase malP 0.055
6021 Adenosine kinase ADK 0.0531
2320 Thymidine kinase, cytosolic TK1 0.0528
2503 Phosphomannomutase/phosphoglucomutase algC 0.0499
2632 Adenylosuccinate synthetase purA 0.0459
3323 Adenylosuccinate synthetase purA 0.0459
3975 Adenylosuccinate synthetase ADSS 0.0459
4598 Adenylosuccinate synthetase Adss 0.0459
6817 Adenylosuccinate synthetase purA 0.0459
2756 Geranyltranstransferase ispA 0.0458
2434 NH(3)-dependent NAD(+) synthetase nadE 0.044
2910 NH(3)-dependent NAD(+) synthetase nadE 0.044
3217 NH(3)-dependent NAD(+) synthetase nadE 0.044
6142 Solute carrier family 22 member 8 SLC22A8 0.0423
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0415
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0415
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0415
338 DNA polymerase UL30 0.0362
379 DNA polymerase UL54 0.0362
697 DNA polymerase ORF28 0.0362
2482 DNA polymerase 43 0.0362
4104 DNA polymerase BALF5 0.0362
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0349
752 Large structural protein L 0.0349
390 Adenosine A3 receptor ADORA3 0.0339
1588 Multidrug resistance protein 1 ABCB1 0.0337
268 Adenosine A2b receptor ADORA2B 0.0323
2427 Ferrichrome-iron receptor fhuA 0.0318
1152 Glycogen phosphorylase, muscle form PYGM 0.031
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0303
6147 Solute carrier family 22 member 3 SLC22A3 0.0289
702 UMP-CMP kinase CMPK1 0.0285
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0268
4119 Cytochrome P450 2D6 CYP2D6 0.0266
118 Organic cation/carnitine transporter 2 SLC22A5 0.0264
1729 Solute carrier family 22 member 6 SLC22A6 0.026
3611 Cytidine deaminase cdd 0.0254
3707 Cytidine deaminase cdd 0.0254
4211 Cytidine deaminase CDA 0.0254
6111 DNA polymerase epsilon subunit 4 POLE4 0.0243
6112 DNA polymerase epsilon subunit 3 POLE3 0.0243
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0243
6110 DNA polymerase epsilon subunit 2 POLE2 0.0243
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0243
16 Adenosine A1 receptor ADORA1 0.0236
1178 Adenosine A2a receptor ADORA2A 0.0236
833 Organic cation/carnitine transporter 1 SLC22A4 0.0234
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0231
4512 Cytochrome P450 3A4 CYP3A4 0.0214
3957 Adenosine deaminase ADA 0.0208
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0205
6148 Multidrug resistance-associated protein 7 ABCC10 0.0196
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.019
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0187
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0186
4200 Cytochrome P450 1A2 CYP1A2 0.0181
1405 Thiopurine S-methyltransferase TPMT 0.0178
6143 Solute carrier family 22 member 7 SLC22A7 0.0177
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.017
6136 Multidrug resistance-associated protein 5 ABCC5 0.0168
3947 Xanthine dehydrogenase/oxidase XDH 0.0165
2164 Multidrug resistance-associated protein 4 ABCC4 0.016
6020 Aldehyde oxidase AOX1 0.0156
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0155
4118 Cytochrome P450 3A5 CYP3A5 0.0141
831 D(2) dopamine receptor DRD2 0.0128
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0128
6016 Cytochrome P450 2C19 CYP2C19 0.0125
587 Serum albumin ALB 0.0125
4757 Cytochrome P450 2C9 CYP2C9 0.0124
23 D(1A) dopamine receptor DRD1 0.0116
6107 Cytochrome P450 3A7 CYP3A7 0.0113
502 5-hydroxytryptamine 2A receptor HTR2A 0.0111
556 Alpha-1A adrenergic receptor ADRA1A 0.0108
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0105
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0103
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0102
2697 Uridine-cytidine kinase 2 UCK2 0.0097
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0093
632 Alpha-1B adrenergic receptor ADRA1B 0.0092
672 Prostaglandin F2-alpha receptor PTGFR 0.009
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
5682 Ribonuclease pancreatic RNASE1 0.0086
474 Acetylcholinesterase ACHE 0.0086
2874 Nitrogenase iron protein 1 nifH1 0.0085
5287 Signaling protein Not Available 0.0085
5288 Shikimate kinase aroK 0.0085
5304 UPF0166 protein TM_0021 TM_0021 0.0085
5283 D-alanine--D-alanine ligase B ddlB 0.0085
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0085
5266 Activator of hgdC 0.0085
5299 D-alanine--D-alanine ligase ddl 0.0085
6598 D-alanine--D-alanine ligase ddl 0.0085
5292 Putative partitioning protein TT_C1605 0.0085
5293 Shikimate kinase 2 aroL 0.0085
3199 Phosphopantetheine adenylyltransferase coaD 0.0085
3543 Phosphopantetheine adenylyltransferase coaD 0.0085
3567 Phosphopantetheine adenylyltransferase coaD 0.0085
5289 Phosphopantetheine adenylyltransferase coaD 0.0085
4346 Polynucleotide kinase pseT 0.0085
5281 Plasmid segregation protein parM parM 0.0085
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0085
5276 Chromosomal replication initiator protein dnaA dnaA 0.0085
5291 Glycogen synthase 1 glgA1 0.0085
5259 Transcriptional regulator ntrC1 0.0085
6699 Transcriptional regulator Cgl2612 0.0085
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0085
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0085
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0085
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0085
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0085
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0085
5264 DNA replication protein REP 0.0085
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0085
5315 Chaperone protein htpG htpG 0.0085
5284 Large T antigen Not Available 0.0085
5308 Preprotein translocase secA 1 subunit secA1 0.0085
5277 Preprotein translocase subunit secA secA 0.0085
5285 Kinesin heavy chain KIF5B 0.0085
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0085
5261 Phosphoribosylformylglycinamidine synthase purL 0.0085
341 5-hydroxytryptamine 3 receptor HTR3A 0.0083
320 5-hydroxytryptamine 1A receptor HTR1A 0.0082
766 Beta-2 adrenergic receptor ADRB2 0.0081
378 Alpha-2C adrenergic receptor ADRA2C 0.008
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
4106 Guanylate kinase GUK1 0.0074
4516 Guanylate kinase gmk 0.0074
413 Amidophosphoribosyltransferase PPAT 0.0074
2515 Amidophosphoribosyltransferase purF 0.0074
3714 Amidophosphoribosyltransferase purF 0.0074
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0074
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0074
4837 Cag-alfa cag-alfa 0.0074
5646 Galactokinase GALK1 0.0074
5302 TrwB trwB 0.0074
4774 NTPase P4 Not Available 0.0074
5265 FtsH ftsH 0.0074
4839 DNA polymerase III subunit tau dnaX 0.0074
4838 PMS1 protein homolog 2 PMS2 0.0074
2270 Dephospho-CoA kinase coaE 0.0074
2284 Adenylate kinase adk 0.0074
2296 Adenylate kinase adk 0.0074
2311 Adenylate kinase adk 0.0074
2312 Adenylate kinase Not Available 0.0074
6277 Heat shock cognate 71 kDa protein HSPA8 0.0074
5189 Trimethylamine dehydrogenase tmd 0.0074
3470 Hypothetical protein MG245 homolog MPN_348 0.0074
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0074
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0074
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0074
3175 Glutamate--cysteine ligase gshA 0.0073
3426 Glutamine synthetase glnA 0.0073
3987 Glutamine synthetase GLUL 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
776 Bile salt export pump ABCB11 0.0072
6024 Cytochrome P450 1A1 CYP1A1 0.0069
629 Alpha-2B adrenergic receptor ADRA2B 0.0069
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0068
2683 Mono-ADP-ribosyltransferase C3 C3 0.0068
2390 Nonsecretory ribonuclease RNASE2 0.0068
5312 Kinesin-like protein KIF1A KIF1A 0.0068
2922 Glycerol kinase glpK 0.0068
5271 Focal adhesion kinase 1 PTK2 0.0068
862 Multidrug resistance-associated protein 1 ABCC1 0.0068
340 Apoptotic protease-activating factor 1 APAF1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
193 Beta-1 adrenergic receptor ADRB1 0.0065
2282 Protein recA recA 0.0064
2315 Protein recA recA 0.0064
2332 Protein recA recA 0.0064
5263 Protein recA recA 0.0064
2615 Chemotaxis protein cheA cheA 0.0064
2371 Pantothenate kinase coaA 0.0064
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0064
3669 Ribokinase rbsK 0.0064
1881 Hexokinase-1 HK1 0.0064
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0064
2892 Acetylglutamate kinase argB 0.0064
3550 Acetylglutamate kinase argB 0.0064
825 Arsenical pump-driving ATPase ASNA1 0.0064
3435 Arsenical pump-driving ATPase arsA 0.0064
5300 Antigen peptide transporter 1 TAP1 0.0064
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0064
492 Histamine H1 receptor HRH1 0.0064
3923 Cholinesterase BCHE 0.0063
408 Riboflavin kinase RFK 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
318 Alpha-2A adrenergic receptor ADRA2A 0.0061
2727 S-adenosylmethionine synthetase metK 0.0061
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0061
5294 Nucleoside diphosphate kinase A NME1 0.0061
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0059
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
788 Creatine kinase M-type CKM 0.0059
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0059
2334 Dethiobiotin synthetase bioD 0.0059
6555 Dethiobiotin synthetase bioD 0.0059
6030 Cytochrome P450 2B6 CYP2B6 0.0058
504 Mast/stem cell growth factor receptor KIT 0.0058
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0057
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0057
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0057
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0056
6013 Cytochrome P450 2E1 CYP2E1 0.0056
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0055
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0054
6395 Myosin-14 MYH14 0.0054
48 Pyridoxal kinase PDXK 0.0054
2091 Endoplasmin HSP90B1 0.0054
4924 Cytochrome P450 2C8 CYP2C8 0.0053
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
5591 Complement component C8 gamma chain C8G 0.0053
124 Histamine H2 receptor HRH2 0.0053
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0053
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0053
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0053
5582 Regulator of transcription; stringent starvation protein A sspA 0.0053
5587 Iron(III)-binding periplasmic protein fbpA 0.0053
2838 Ribose-5-phosphate isomerase A rpiA 0.0053
2952 Ribose-5-phosphate isomerase A rpiA 0.0053
5595 Ribose-5-phosphate isomerase A rpiA 0.0053
5590 N utilization substance protein B homolog nusB 0.0053
5593 Transferase Not Available 0.0053
5588 Cell division protein FtsY TM_0570 0.0053
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0053
5575 Short tail fiber protein 12 0.0053
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0053
4238 50S ribosomal protein L4 rplD 0.0053
5578 50S ribosomal protein L4 rplD 0.0053
6173 50S ribosomal protein L4 rplD 0.0053
6219 50S ribosomal protein L4 rplD 0.0053
4695 UPF0124 protein yfiH yfiH 0.0053
5581 Beta-fructosidase bfrA 0.0053
5060 Intron-associated endonuclease 1 ITEVIR 0.0053
5600 Pyruvate decarboxylase pdc 0.0053
4375 Glutamine synthetase 1 glnA1 0.0053
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0053
5580 Hexon protein PII 0.0053
5574 Invasin YPTB1668 0.0053
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0052
1422 Serine/threonine-protein kinase 6 AURKA 0.0052
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0052
3379 Kinesin-like protein KIF11 KIF11 0.0051
207 Glutathione synthetase GSS 0.005
5269 Glutathione synthetase gshB 0.005
3456 Heat shock protein HSP 90-beta HSP90AB1 0.005
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.005
3822 Actin, alpha skeletal muscle ACTA1 0.0049
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
789 Alpha-1D adrenergic receptor ADRA1D 0.0048
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0047
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0047
4992 Cytochrome c peroxidase Not Available 0.0047
731 HIV-1 protease HIV-1 protease 0.0047
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0047
3729 Citrate synthase gltA 0.0046
4575 Citrate synthase cit 0.0046
4580 Citrate synthase gltA 0.0046
5328 Prostaglandin F synthase Tb11.02.2310 0.0046
3132 Tryptophan synthase alpha chain trpA 0.0046
6568 Tryptophan synthase alpha chain trpA 0.0046
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0046
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0046
5006 RNASE4 protein RNASE4 0.0046
4533 Glyoxalase family protein BC_1747 0.0046
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0046
2555 Pol polyprotein pol 0.0046
3242 Pol polyprotein gag-pol 0.0046
3471 Pol polyprotein gag-pro-pol 0.0046
5256 Pol polyprotein pol 0.0046
6469 Pol polyprotein gag-pol 0.0046
6565 Pol polyprotein Not Available 0.0046
1721 Glycogen synthase kinase-3 beta GSK3B 0.0045
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
756 Sex hormone-binding globulin SHBG 0.0044
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0043
2521 Cell division protein ftsZ ftsZ 0.0043
3301 Cell division protein ftsZ ftsZ 0.0043
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0043
2149 Angiogenin ANG 0.0043
2603 Beta-lactamase II blm 0.0042
3583 6-phosphogluconolactonase pgl 0.0042
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0042
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0042
6070 Nischarin NISCH 0.0041
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
2942 Sialidase nanH 0.004
3546 Sialidase nedA 0.004
857 Malate dehydrogenase, mitochondrial MDH2 0.004
3486 Fumarate hydratase class II fumC 0.004
2286 Isocitrate dehydrogenase [NADP] icd 0.004
2302 Isocitrate dehydrogenase [NADP] icd 0.004
2771 Isocitrate dehydrogenase [NADP] icd 0.004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.004
540 Sodium-dependent noradrenaline transporter SLC6A2 0.004
3939 Amine oxidase [flavin-containing] B MAOB 0.0039
1024 Solute carrier family 22 member 11 SLC22A11 0.0039
694 Matrix protein 2 M 0.0039
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0039
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0039
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0039
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0039
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
332 Beta-lactamase blaZ 0.0037
2478 Beta-lactamase ampC 0.0037
2613 Beta-lactamase ampC 0.0037
2635 Beta-lactamase ampC 0.0037
2700 Beta-lactamase penP 0.0037
5445 Beta-lactamase blaB 0.0037
6019 Beta-lactamase SHV-7 0.0037
6701 Beta-lactamase cphA 0.0037
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0037
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0037
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0037
2452 Tryptophanyl-tRNA synthetase trpS 0.0037
6106 Cytochrome P450 2C18 CYP2C18 0.0036
1830 5'-nucleotidase NT5E 0.0035
5579 Carboxypeptidase B CPB1 0.0035
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0035
824 Sodium-dependent serotonin transporter SLC6A4 0.0034
136 Estrogen receptor ESR1 0.0034
125 DNA polymerase beta POLB 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
3384 Macrophage migration inhibitory factor MIF 0.0034
6141 Sodium/bile acid cotransporter SLC10A1 0.0034
411 Glycine N-methyltransferase GNMT 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
128 Adenine phosphoribosyltransferase APRT 0.0032
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0032
1898 Cytochrome P450 1B1 CYP1B1 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
449 Ornithine decarboxylase ODC1 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
869 Estrogen receptor beta ESR2 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.003
5126 Arginase rocF 0.0029
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0029
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0029
713 Sodium-dependent dopamine transporter SLC6A3 0.0029
738 Monocarboxylate transporter 1 SLC16A1 0.0028
1341 Histamine H3 receptor HRH3 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0027
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
822 Aldose reductase AKR1B1 0.0027
740 Argininosuccinate synthase ASS1 0.0027
865 Argininosuccinate synthase ASS1 0.0027
2680 Argininosuccinate synthase argG 0.0027
3194 Argininosuccinate synthase argG 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
164 Histamine H4 receptor HRH4 0.0026
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0026
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
163 D(1B) dopamine receptor DRD5 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
432 D(4) dopamine receptor DRD4 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0022
6166 Organic solute transporter subunit alpha OSTA 0.0022
638 D(3) dopamine receptor DRD3 0.0022
4203 Histamine N-methyltransferase HNMT 0.0021
976 Platelet glycoprotein IX GP9 0.0021
6014 Cytochrome P450 2A13 CYP2A13 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
465 Calmodulin CALM1 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
20 Prostaglandin G/H synthase 1 PTGS1 0.002
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
6432 Transporter snf 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
5718 Cytochrome P450 2A6 CYP2A6 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0017
2300 Lysozyme E 0.0017
3633 Lysozyme R 0.0017
5597 Lysozyme 17 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
1864 RET proto-oncogene RET 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
6146 High affinity copper uptake protein 1 SLC31A1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
3811 Cytochrome P450 19A1 CYP19A1 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
6218 Pannexin-1 PANX1 0.0014
751 Potassium channel subfamily K member 6 KCNK6 0.0014
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0013
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0013
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
172 Potassium channel subfamily K member 1 KCNK1 0.0012
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0012
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
885 5-hydroxytryptamine 1B receptor HTR1B 0.0012
3587 Gastrotropin FABP6 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
1757 Myeloperoxidase MPO 0.0012
3810 Catechol O-methyltransferase COMT 0.0011
590 5-hydroxytryptamine 2C receptor HTR2C 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
904 Glutathione S-transferase P GSTP1 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
380 Cytochrome P450 17A1 CYP17A1 0.0011
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
737 Mineralocorticoid receptor NR3C2 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
614 Progesterone receptor PGR 0.0009
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0009
6031 Cytochrome P450 3A43 CYP3A43 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
6085 Fatty acid-binding protein, intestinal FABP2 0.0009
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0009
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0008
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0008
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0007
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0007
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0007
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
146 Androgen receptor AR 0.0007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0007
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0006
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0006
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0006
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
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