| Name |
Ribonucleoside-diphosphate reductase 2 alpha subunit |
| Synonyms |
5280 |
| Gene name |
nrdE |
| General function |
Nucleotide transport and metabolism |
| Specific function |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide |
| Gene sequence |
+ ...
TTGGCAACAACTACCCCGGAGCGCGTAATGCAGGAAACCATGGATTACCACGCCCTGAACGCGATGCTGAATCTTTACGATAAAGCAGGCCATATTCAGTTCGACAAGGACCAGCAGGCGATCGACGCCTTCTTTGCCACCCACGTCCGCCCGCATTCCGTGACGTTTGCCAGCCAGCATGAACGTCTGGGGACGCTGGTTCGGGAAGGGTATTACGATGACGCCGTCCTCGCGCGTTACGACCGCGCCTTCGTCCTTCGCCTGTTCGAGCACGCCCATGCCAGCGGCTTTCGCTTCCAGACGTTTCTTGGCGCCTGGAAGTTCTATACCAGTTACACGCTGAAAACCTTCGACGGCAAACGTTATCTGGAACACTTTGAAGATCGGGTGACAATGGTGGCGTTGACGCTGGCGCAGGGTGACGAAACGCTGGCCACCCAACTGACCGATGAAATGCTTTCTGGTCGCTTTCAGCCCGCTACCCCGACTTTTTTAAATTGCGGCAAACAGCAGCGTGGGGAACTGGTCTCCTGCTTCCTGCTCCGTATCGAAGACAACATGGAGTCGATCGGGCGGGCGGTGAATTCGGCGCTGCAACTCTCCAAACGCGGCGGCGGCGTCGCGTTTTTACTCTCCAATCTGCGCGAGGCGGGCGCGCCGATCAAACGCATTGAGAATCAGTCTTCCGGCGTGATCCCGGTGATGAAAATGCTGGAAGACGCGTTTTCGTATGCCAACCAACTTGGCGCGCGCCAGGGGGCCGGCGCGGTTTATCTCCATGCGCACCATCCGGATATTCTGCGTTTTCTGGATACCAAACGAGAAAACGCTGACGAAAAAATCCGGATCAAAACGCTCTCTCTCGGCGTGGTGATCCCGGATATCACCTTCCGGCTGGCGAAAGAAAACGCGCAAATGGCGCTCTTTTCGCCCTATGACATACAACGACGCTACGGCAAACCGTTTGGCGATATCGCCATTAGCGAACGGTACGATGAATTAATTGCCGATCCGCACGTGCGCAAAACCTATATTAACGCCCGTGACTTTTTTCAAACACTGGCGGAGATTCAGTTCGAATCCGGGTATCCCTACATCATGTTTGAAGATACGGTAAACCGCGCGAATCCCATTGCTGGTCGCATTAATATGAGCAACCTGTGCTCAGAAATTTTACAGGTCAATAGCGCTTCCCGTTACGACGATAACCTTGACTATACCCACATCGGGCATGACATCTCCTGCAATCTCGGCTCGCTGAATATCGCTCACGTCATGGATTCACCGGACATTGGCCGTACCGTAGAAACCGCTATTCGCGGCCTGACGGCGGTGTCGGACATGAGCCATATACGCAGCGTGCCCTCAATAGCCGCCGGTAATGCCGCCTCTCATGCCATCGGTCTGGGCCAGATGAATCTGCATGGCTATCTGGCGAGGGAAGGTATTGCCTACGGTTCGCCGGAGGCGTTGGATTTCACCAATCTCTATTTTTACACCATTACCTGGCATGCCGTGCATACTTCAATGCGGCTAGCCCGCGAACGCGGCAAAACCTTCGCCGGATTTGCGCAGTCGCGCTATGCCAGCGGCGACTATTTTACGCAGTATTTACAGGACGACTGGCAACCGAAAACAGCGAAAGTCAGGGCGCTATTTGCCCGCAGCGGCATTACGCTGCCCACACGAGAAATGTGGCTAAAGCTGCGCGACGATGTGATGCGCTATGGCATCTATAACCAAAATTTGCAGGCGGTGCCGCCGACCGGTTCGATTTCTTACATTAATCATGCGACCTCCAGCATTCATCCGATTGTGGCCAAAATTGAGATTCGCAAAGAGGGCAAAACCGGGCGTGTGTATTACCCCGCGCCGTTTATGACCAATGAAAACCTGGACATGTATCAGGATGCTTACGATATCGGTCCGGAAAAAATTATTGATACCTATGCCGAGGCCACGCGCCACGTCGATCAAGGGCTGTCGCTCACCCTGTTTTTCCCCGATACCGCCACGACCCGCGATATCAACAAGGCGCAGATCTATGCCTGGCGAAAAGGTATTAAGTCCCTGTATTACATCCGGCTTCGCCAGTTGGCGCTGGAAGGTACTGAAATTGAAGGCTGCGTATCCTGCGCGCTATAA
|
| Protein sequence |
+ ...
MATTTPERVMQETMDYHALNAMLNLYDKAGHIQFDKDQQAIDAFFATHVRPHSVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYGKPFGDIAISERYDELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAGRINMSNLCSEILQVNSASRYDDNLDYTHIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFARSGITLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTEIEGCVSCAL
|
| GO Classification |
| component |
| ribonucleoside-diphosphate reductase complex |
| protein complex |
| function |
| oxidoreductase activity, acting on CH2 groups |
| oxidoreductase activity, acting on CH2 groups, disulfide as acceptor |
| ribonucleoside-diphosphate reductase activity |
| catalytic activity |
| oxidoreductase activity |
| process |
| DNA metabolism |
| physiological process |
| metabolism |
| cellular metabolism |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| DNA replication |
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