DT-Web

DB01692 - Dithioerythritol


Identification
Name Dithioerythritol
Accession Number DB01692 (EXPT01292)
Type small molecule
Description A compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 154.251
Groups experimental
Monoisotopic Weight 154.012220944
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Listeriolysin regulatory protein
Name Listeriolysin regulatory protein
Gene Name prfA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7776
6,7-dimethyl-8-ribityllumazine synthase
Name 6,7-dimethyl-8-ribityllumazine synthase
Gene Name ribH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 2.1134
Thymidine kinase, cytosolic
Name Thymidine kinase, cytosolic
Gene Name TK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5199

Predictions


Id Partner name Gene Name Score
2642 6,7-dimethyl-8-ribityllumazine synthase ribH 2.1134
3216 6,7-dimethyl-8-ribityllumazine synthase ribH 2.1134
3605 Thermonuclease nuc 0.308
3639 Thymidine phosphorylase deoA 0.0749
3936 Thymidine phosphorylase TYMP 0.0749
24 Thymidylate synthase TMP1 0.0587
359 Thymidylate synthase TYMS 0.0587
2626 Thymidylate synthase thyA 0.0587
2729 Thymidylate synthase thyA 0.0587
5352 Thymidylate synthase THYA 0.0587
509 Thymidine kinase TK 0.0565
570 Thymidine kinase TK 0.0565
2559 Thymidine kinase TK 0.0565
3430 Thymidine kinase tdk 0.0565
3518 Thymidine kinase TK 0.0565
5301 Thymidine kinase tdk 0.0565
5771 Thymidine kinase ORF36 0.0565
7009 Thymidine kinase ORF36 0.0565
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.0563
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0482
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0482
3299 DNA primase/helicase 4 0.0477
3244 Ribonucleoside-diphosphate reductase 2 alpha subunit nrdE 0.0441
1729 Solute carrier family 22 member 6 SLC22A6 0.0433
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0413
2251 Thymidylate kinase tmk 0.0372
2254 Thymidylate kinase DTYMK 0.0372
3522 Thymidylate kinase tmk 0.0372
5669 50S ribosomal protein L27 rpmA 0.0322
5675 Chaperone protein torD torD 0.0322
5670 Organic hydroperoxide resistance protein ohr 0.0322
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0322
5410 Unsaturated glucuronyl hydrolase ugl 0.0321
5676 Axin-1 AXIN1 0.0321
5673 C protein alpha-antigen bca 0.0321
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.028
3317 Holo-[acyl-carrier-protein] synthase acpS 0.028
4381 Holo-[acyl-carrier-protein] synthase acpS 0.028
2636 Shikimate dehydrogenase aroE 0.028
3515 Shikimate dehydrogenase aroE 0.028
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.028
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0258
4811 Amylosucrase ams 0.0258
4217 Telomerase reverse transcriptase TERT 0.0254
3191 Histidinol dehydrogenase hisD 0.0244
191 Peptide methionine sulfoxide reductase MSRA 0.023
909 Maleylacetoacetate isomerase GSTZ1 0.0227
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0223
2314 Triosephosphate isomerase TPI 0.0196
3417 Triosephosphate isomerase tpiA 0.0196
3443 Triosephosphate isomerase tpiA 0.0196
6346 Triosephosphate isomerase TPI1 0.0196
611 Retinal dehydrogenase 1 ALDH1A1 0.0175
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0149
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0149
6136 Multidrug resistance-associated protein 5 ABCC5 0.0117
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0103
6143 Solute carrier family 22 member 7 SLC22A7 0.0098
1024 Solute carrier family 22 member 11 SLC22A11 0.0097
2164 Multidrug resistance-associated protein 4 ABCC4 0.0097
6144 Solute carrier family 22 member 2 SLC22A2 0.0089
6142 Solute carrier family 22 member 8 SLC22A8 0.0086
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0086
5718 Cytochrome P450 2A6 CYP2A6 0.0086
587 Serum albumin ALB 0.0078
4924 Cytochrome P450 2C8 CYP2C8 0.0071
6016 Cytochrome P450 2C19 CYP2C19 0.0068
1588 Multidrug resistance protein 1 ABCB1 0.0066
4757 Cytochrome P450 2C9 CYP2C9 0.0065
4512 Cytochrome P450 3A4 CYP3A4 0.0058
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