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Protease synthase and sporulation negative regulatory protein PAI 1


Partner ID 3125
Name Protease synthase and sporulation negative regulatory protein PAI 1
Synonyms 4016
Gene name paiA
General function Transcription
Specific function Possesses N1-acetyltransferase activity toward polyamine substrates including spermidine and spermine. capable of acetylating both spermidine and spermine. In this way it may function in regulating intracellular polyamine concentrations and/or binding capabilities. In addition to preventing toxicity due to polyamine excess, this function may also serve to regulate expression of certain bacterial gene products such as those involved in sporulation
Gene sequence + ...

ATGAGTGTAAAAATGAAAAAATGCAGCCGGGAAGATTTACAAACACTTCAACAATTGAGTATTGAAACATTCAATGACATTTTTAAAGAACAGAACTCACCTGAAAATATGAAAGCCTATTTAGAAAGCGCATTTAACACTGAGCAGCTGGAAAAAGAGTTATCTAATATGTCTTCGCAATTCTTTTTTATTTACTTTGATCATGAAATCGCTGGATATGTAAAGGTCAATATCGATGATGCTCAGTCTGAAGAAATGGGTGCTGAATCACTTGAAATCGAGAGAATTTATATAAAGAACAGCTTTCAAAAACATGGGCTTGGCAAACATCTGCTGAATAAAGCGATAGAAATTGCGCTGGAACGTAATAAAAAGAACATTTGGCTAGGTGTGTGGGAAAAAAATGAAAATGCCATTGCCTTTTATAAGAAAATGGGGTTTGTTCAGACCGGCGCCCACTCATTTTATATGGGTGATGAAGAACAAACGGATTTAATCATGGCTAAAACACTCATATAA
Protein sequence + ...

MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESAFNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSFQKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDEEQTDLIMAKTLI
GO Classification
function
catalytic activity
transferase activity
acetyltransferase activity
transferase activity, transferring acyl groups
transferase activity, transferring groups other than amino-acyl groups
acyltransferase activity
N-acetyltransferase activity
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Drugs


Associated as Target

Id Name
DB01992 Coenzyme A
DB04447 1,4-Dithiothreitol

Associated as Prediction

Id Name
DB00134 L-Methionine
DB00143 Glutathione
DB00157 NADH
DB00162 Vitamin A
DB00172 L-Proline
DB00175 Pravastatin
DB00227 Lovastatin
DB00439 Cerivastatin
DB00583 L-Carnitine
DB00641 Simvastatin
DB00684 Tobramycin
DB00755 Tretinoin
DB01034 Cerulenin
DB01076 Atorvastatin
DB01095 Fluvastatin
DB01098 Rosuvastatin
DB01172 Kanamycin
DB01669 Virginiamycin M1
DB01692 Dithioerythritol
DB01695 N-Hydroxy-4-Phosphono-Butanamide
DB01764 Dalfopristin
DB01783 Pantothenic acid
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01846 Oxidized Coenzyme A
DB01856 Pimelic Acid
DB01862 1-(Isopropylthio)-Beta-Galactopyranside
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01915 S-Hydroxycysteine
DB01992 Coenzyme A
DB02031 (6s)-5,6,7,8-Tetrahydrofolate
DB02039 S-Acetyl-Cysteine
DB02160 S-Butyryl-Cystein
DB02175 Malonic acid
DB02223 Ly231514 Tetra Glu
DB02256 2'-Deoxyuridine
DB02301 5,10-Methylene-6-Hydrofolic Acid
DB02316 1-(5-Carboxypentyl)-5-[(2,6-Dichlorobenzyl)Oxy]-1 H-Indole-2-Carboxylic Acid
DB02379 Beta-D-Glucose
DB02467 S-Oxymethionine
DB02516 O5'-(4-(3-{2-[2-((R)-3-Hydroxy-4-(Trimethylammonio)-1-Oxo-Butyl)Sulfanyl-Ethylcarbamoyl]-Ethylcarbamoyl}-(R)-3-Hydroxy-2,2-Dimethyl-Propyl)-1-Hydroxy-3-Oxido-1,3-Dioxo-2,4-Dioxa-1,3-Diphosphabut-1-Yl) 3'-Phospho-Adenosine
DB02632 1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose
DB02648 (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium
DB02726 2-Phosphoglycolic Acid
DB02752 Tosyl-D-Proline
DB02772 Sucrose
DB02899 N-Carboxymethionine
DB03026 Phosphoglycolohydroxamic Acid
DB03038 LY341770
DB03045 Pantothenyl-Aminoethanol-Acetate Pivalic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid
DB03134 2-Aminopimelic Acid
DB03135 [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid
DB03157 N,O-Didansyl-L-Tyrosine
DB03169 (S)-Hmg-Coa
DB03170 Dephospho Coenzyme A
DB03230 Adenosine-5'-Propylphosphate
DB03274 2'-5'dideoxyuridine
DB03278 D-Treitol
DB03314 Fluorotryptophane
DB03379 2-Carboxyethylphosphonic Acid
DB03397 Uridine-Diphosphate-N-Acetylglucosamine
DB03431 Adenosine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03499 Malate Ion
DB03518 (R)-Mevalonate
DB03541 10-Propargyl-5,8-Dideazafolic Acid
DB03558 Sp-876
DB03566 Spermidine
DB03613 4-Hydroxyphenacyl Coenzyme A
DB03615 Ribostamycin
DB03654 S,S-Propylthiocysteine
DB03661 Cysteinesulfonic Acid
DB03699 Succinyl-Coenzyme A
DB03761 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
DB03785 (3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
DB03800 2'-deoxyuridylic acid
DB03811 Histidinol
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03818 N-[Tosyl-D-Prolinyl]Amino-Ethanethiol
DB03900 2-Methyl-2-Propanol
DB03905 Succinamide-Coa
DB03912 4'-Phosphopantetheine
DB03940 Oxamic Acid
DB04067 4-Hydroxybenzyl Coenzyme A
DB04077 Glycerol
DB04119 Hexatantalum Dodecabromide
DB04242 P-Hydroxybenzoic Acid
DB04272 Citric Acid
DB04326 1,3-Dihydroxyacetonephosphate
DB04343 Glyoxalate, Glyoxylate
DB04377 3-Hydroxy-3-Methyl-Glutaric Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04447 1,4-Dithiothreitol
DB04457 2'-Deoxyguanosine-5'-Monophosphate
DB04503 Sp-722
DB04510 3-Phosphoglyceric Acid
DB04524 Malonyl-Coenzyme A
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04586 2-bromophenol
DB04696 4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN
DB06693 Mevastatin
DB06846 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
DB07387 3-(BUTYLSULPHONYL)-PROPANOIC ACID
DB07766 (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
DB08120 6,8-DIMERCAPTO-OCTANOIC ACID AMIDE
DB08131 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-3-METHYL-BUTYRIC ACID
DB08186 (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
DB08291 N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
DB08328 PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACID
DB08408 (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoate
DB08860 Pitavastatin
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