DT-Web: DB00641

Identification

Name

Simvastatin

Accession Number

DB00641 (APRD00104)

Type

small molecule

Description

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

418.5662

Groups

approved

Monoisotopic Weight

418.271924326

Pharmacology

Indication

For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.

Mechanism of action

Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Absorption

Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues. However, because simvastatin undergoes extensive first-pass metabolism, the availability of the drug in the systemic is low. Peak plasma concentration occurs 1.3 - 2.4 hours after administration.

Protein binding

Both simvastatin and its ?-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.

Biotransformation

Hepatic, simvastatin is a substrate for CYP3A4. The major active metabolites of simvastatin are ?-hydroxyacid metabolite and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives

Route of elimination

Following an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.

Toxicity

The most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amiodarone	Increased risk of rhabdomyolysis
Amprenavir	Amprenavir may increase the effect and toxicity of simvastatin. Concomitant therapy is contraindicated.
Atazanavir	Increased risk of myopathy/rhabdomyolysis
Bosentan	Bosentan may decrease the serum concentration of simvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if bosentan is initiated, discontinued or dose changed.
Carbamazepine	Carbamazepine, a p-glycoprotein inducer, may decrease the effect of simvastatin by increasing its efflux. Monitor for changes in the therapeutic and adverse effects of simvastatin if carbamazepine is initiated, discontinued or dose changed.
Clarithromycin	The macrolide, clarithromycin, may increase the toxicity of the statin, simvastatin.
Colchicine	Increased risk of rhabdomyolysis with this combination
Cyclosporine	Possible myopathy and rhabdomyolysis
Delavirdine	Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if delavirdine is initiated, discontinued or dose changed.
Diltiazem	Diltiazem may increase the serum concentration of simvastatin. Simvastatin may increase the serum concentration of diltiazem. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Dronedarone	Dronedarone is a CYP2D6 inhibitor thus increasing serum concentrations of simvastatin 4-fold. Lower doses of simvastatin and doses should not exceed 20 mg to avoid statin-induced toxicities like myopathy. Consider rosuvastatin as cholesterol lowering therapy as there is no significant interaction between rosuvastatin and dronedarone.
Efavirenz	Efavirenz may decrease the serum concentration of simvastatin. Monitor for changes in the therapeutic and adverse effects of simvastatin if efavirenz is initiated, discontinued or dose changed.
Erythromycin	The macrolide, erythromycin, may increase the toxicity of the statin, simvastatin.
Etravirine	Simvastatin, when administered concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to monitor continued efficacy of simvastatin therapy.
Fenofibrate	Increased risk of myopathy/rhabdomyolysis
Fluconazole	Increased risk of myopathy/rhabdomyolysis
Fosamprenavir	Fosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if fosamprenavir is initiated, discontinued or dose changed.
Fusidic Acid	Increased risk of myopathy/rhabdomyolysis
Gemfibrozil	Increased risk of myopathy/rhabdomyolysis
Imatinib	Imatinib, a strong CYP3A4 inhibitor, may increase the effect and toxicity of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if imatinib is initiated, discontinued or dose changed.
Itraconazole	Increased risk of myopathy/rhabdomyolysis
Ketoconazole	Increased risk of myopathy/rhabdomyolysis
Lomitapide	Simvastatin plasma concentrations are doubled by lomitapide. To prevent dose related adverse effects such as myopathy and rhabdomyolysis it is recommended to reduce the dose of simvastatin by 50%. See FDA label for additional dosage instructions.
Nefazodone	Nefazodone may increase the effect and toxicity of simvastatin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of simvastatin if nefazodone is initiated, discontinued or dose changed.
Nelfinavir	Nelfinavir may increase the effect and toxicity of simvastatin. Concomitant therapy should be avoided.
Nevirapine	The strong CYP3A4 inducer, nevirapine, may decrase the effect of simvastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of simvastatin if nevirapine is initiated, discontinued or dose changed.
Pazopanib	Elevated liver enzyme levels may be observed with concomitant therapy with pazopanib. Monitor closely for adverse effects.
Quinupristin	This combination presents an increased risk of toxicity
Ranolazine	Ranolazine may increase the serum concentration of simvastatin. Monitor for changes in the therapeutic and adverse effects of simvastatin if ranolazine is initiated, discontinued or dose changed.
Rifabutin	Rifabutin may decrease the effect of simvastatin by increasing its metabolism. Monitor for changes in the therapeutic effect of simvastatin if rifabutin is initiated, discontinued or dose changed.
Rifampin	Rifampin may decrease the effect of simvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if rifampin is initiated, discontinued or dose changed.
Saxagliptin	Simvastatin is a moderate inhibitor of CYP3A4 and increases AUC of saxagliptin by 12%. Exposure of the active metabolite decreased by 2%. However, these changes in pharmacokinetics are not clinical significant.
Telaprevir	Telaprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Telithromycin	Telithromycin may increase the adverse effects of simvastatin by decreasing its metabolism. Concomitant therapy should be avoided.
Ticagrelor	Patients receiving more than 40 mg per day of simvastatin may be at increased risk of statin-related adverse effects.
Tipranavir	Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Simvastatin. Concomitant therapy is contraindicated.
Tocilizumab	Simvastatin is a CYP3A4 and OATP1B1 substrate. Exposure of simvastatin decreases following administration of tocilizumab.
Verapamil	Verapamil, a moderate CYP3A4 inhibitor, may increase the serum concentration of Simvastatin by decreasing its metabolism. Avoid concurrent use if possible or reduce Simvastatin dose during concomitant therapy. Monitor for changes in the therapeutic/adverse effects of Simvastatin if Verapamil is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastain if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Avoid drastic changes in dietary habit.
Avoid alcohol.
Avoid taking with grapefruit juice.

3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name	HMGCR
Pharmacological action	yes
Actions	inhibitor
References	Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. - Pubmed Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. - Pubmed Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. - Pubmed Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides] Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. - Pubmed
DTHybrid score	0.4735
Integrin beta-2
Name	Integrin beta-2
Gene Name	ITGB2
Pharmacological action	no
Actions	other
References	Fujii T, Masuyama K, Kawashima K: Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. J Neuroimmunol. 2006 Oct;179(1-2):101-7. Epub 2006 Jul 10. - Pubmed Fujii T, Takada-Takatori Y, Kawashima K: Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity. Life Sci. 2007 May 30;80(24-25):2320-4. Epub 2007 Jan 17. - Pubmed Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23. - Pubmed Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Clin Immunol. 2005 Sep;116(3):211-6. - Pubmed
DTHybrid score	0.1534

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. - Pubmed Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Information Hyperlinked Over Proteins (iHOP) - - Website Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. - Pubmed
DTHybrid score	1.0406
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6252
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4825
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. - Pubmed Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. - Pubmed Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6354
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor,inducer
References	Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7754
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
DTHybrid score	0.6529
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6937
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4814
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer -
DTHybrid score	0.3892
UDP-glucuronosyltransferase 1-3
Name	UDP-glucuronosyltransferase 1-3
Gene Name	UGT1A3
Actions	substrate
References	http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer -
DTHybrid score	0.3466
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer -
DTHybrid score	0.3689

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T: Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. - Pubmed Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. - Pubmed
DTHybrid score	0.7524
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. - Pubmed
DTHybrid score	0.3593
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate,inhibitor
References	Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. - Pubmed Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B15, SLCO1B115 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. - Pubmed
DTHybrid score	0.4357
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Becker ML, Elens LL, Visser LE, Hofman A, Uitterlinden AG, van Schaik RH, Stricker BH: Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Pharmacogenomics J. 2013 Jun;13(3):251-6. doi: 10.1038/tpj.2011.59. Epub 2011 Dec 20. - Pubmed
DTHybrid score	0.3779

Id	Partner name	Gene Name	Score
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.4735
4200	Cytochrome P450 1A2	CYP1A2	0.4257
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.2403
587	Serum albumin	ALB	0.2291
6013	Cytochrome P450 2E1	CYP2E1	0.2219
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1916
20	Prostaglandin G/H synthase 1	PTGS1	0.1846
6024	Cytochrome P450 1A1	CYP1A1	0.182
5718	Cytochrome P450 2A6	CYP2A6	0.1689
862	Multidrug resistance-associated protein 1	ABCC1	0.1646
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1476
1729	Solute carrier family 22 member 6	SLC22A6	0.145
776	Bile salt export pump	ABCB11	0.1188
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1173
2164	Multidrug resistance-associated protein 4	ABCC4	0.1136
290	Prostaglandin G/H synthase 2	PTGS2	0.1084
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1056
6106	Cytochrome P450 2C18	CYP2C18	0.1043
492	Histamine H1 receptor	HRH1	0.1043
6142	Solute carrier family 22 member 8	SLC22A8	0.1004
6145	Solute carrier family 22 member 1	SLC22A1	0.1002
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0934
824	Sodium-dependent serotonin transporter	SLC6A4	0.0889
4604	Liver carboxylesterase 1	CES1	0.083
847	Mu-type opioid receptor	OPRM1	0.0828
6141	Sodium/bile acid cotransporter	SLC10A1	0.0782
6143	Solute carrier family 22 member 7	SLC22A7	0.0761
6144	Solute carrier family 22 member 2	SLC22A2	0.0743
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0736
70	Type-1 angiotensin II receptor	AGTR1	0.0735
1898	Cytochrome P450 1B1	CYP1B1	0.0734
3811	Cytochrome P450 19A1	CYP19A1	0.0724
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0713
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0703
467	Delta-type opioid receptor	OPRD1	0.0701
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0682
696	Kappa-type opioid receptor	OPRK1	0.0672
118	Organic cation/carnitine transporter 2	SLC22A5	0.066
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0651
731	HIV-1 protease	HIV-1 protease	0.0643
556	Alpha-1A adrenergic receptor	ADRA1A	0.0642
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0635
831	D(2) dopamine receptor	DRD2	0.0628
136	Estrogen receptor	ESR1	0.0621
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0608
1024	Solute carrier family 22 member 11	SLC22A11	0.0589
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0585
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0561
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0547
871	Glucocorticoid receptor	NR3C1	0.0546
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0546
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0544
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0539
766	Beta-2 adrenergic receptor	ADRB2	0.0537
6031	Cytochrome P450 3A43	CYP3A43	0.0535
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0507
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0503
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0499
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0492
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0489
817	DNA topoisomerase 2-alpha	TOP2A	0.0477
6148	Multidrug resistance-associated protein 7	ABCC10	0.0474
713	Sodium-dependent dopamine transporter	SLC6A3	0.0463
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0459
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0456
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0446
146	Androgen receptor	AR	0.0443
6136	Multidrug resistance-associated protein 5	ABCC5	0.0435
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0427
632	Alpha-1B adrenergic receptor	ADRA1B	0.0426
468	Cytochrome P450 4A11	CYP4A11	0.0426
260	Cytochrome P450 51	ERG11	0.0423
761	Cytochrome P450 51	ERG11	0.0423
3163	Cytochrome P450 51	cyp51	0.0423
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0418
4589	3-hydroxy-3-methylglutaryl CoA synthase	mvaS	0.0417
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0417
5880	Thrombopoietin receptor	MPL	0.0417
318	Alpha-2A adrenergic receptor	ADRA2A	0.0405
833	Organic cation/carnitine transporter 1	SLC22A4	0.0404
6147	Solute carrier family 22 member 3	SLC22A3	0.0401
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0384
504	Mast/stem cell growth factor receptor	KIT	0.0383
26	Vascular endothelial growth factor receptor 3	FLT4	0.0383
193	Beta-1 adrenergic receptor	ADRB1	0.0382
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0381
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0371
32	Vascular endothelial growth factor receptor 1	FLT1	0.0366
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0361
23	D(1A) dopamine receptor	DRD1	0.0359
3941	Amine oxidase [flavin-containing] A	MAOA	0.0358
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0352
6137	Multidrug resistance-associated protein 6	ABCC6	0.035
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0341
407	Vascular endothelial growth factor receptor 2	KDR	0.0338
6182	Cytochrome P450 2J2	CYP2J2	0.0336
465	Calmodulin	CALM1	0.0335
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0332
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.033
738	Monocarboxylate transporter 1	SLC16A1	0.033
33	Cystine/glutamate transporter	SLC7A11	0.0326
614	Progesterone receptor	PGR	0.0324
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0323
3923	Cholinesterase	BCHE	0.0322
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0319
6220	Aryl hydrocarbon receptor	AHR	0.0318
737	Mineralocorticoid receptor	NR3C2	0.0317
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0315
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0315
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0315
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0314
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0313
638	D(3) dopamine receptor	DRD3	0.0312
811	Translocator protein	TSPO	0.0299
756	Sex hormone-binding globulin	SHBG	0.0297
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0291
122	P2Y purinoceptor 12	P2RY12	0.0288
789	Alpha-1D adrenergic receptor	ADRA1D	0.0287
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0285
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0283
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0279
6044	Serum paraoxonase/lactonase 3	PON3	0.0277
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0276
6102	Arylamine N-acetyltransferase 2	NAT2	0.0274
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0274
6026	Alcohol dehydrogenase 6	ADH6	0.0273
4122	Histone deacetylase 2	HDAC2	0.0262
3587	Gastrotropin	FABP6	0.0261
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.026
952	Dipeptidyl peptidase 4	DPP4	0.026
380	Cytochrome P450 17A1	CYP17A1	0.0257
844	Epidermal growth factor receptor	EGFR	0.0257
572	Integrin alpha-L	ITGAL	0.0257
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0256
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0256
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0248
869	Estrogen receptor beta	ESR2	0.0247
4120	NADPH--cytochrome P450 reductase	POR	0.0246
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0245
6085	Fatty acid-binding protein, intestinal	FABP2	0.0245
1760	Aminopeptidase N	ANPEP	0.0244
6843	Aminopeptidase N	pepN	0.0244
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0241
3939	Amine oxidase [flavin-containing] B	MAOB	0.024
117	Sterol O-acyltransferase 1	SOAT1	0.0238
904	Glutathione S-transferase P	GSTP1	0.0238
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0236
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0234
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0229
3810	Catechol O-methyltransferase	COMT	0.0228
29	Tubulin beta-1 chain	TUBB1	0.0226
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0224
477	DNA topoisomerase 4 subunit A	parC	0.0223
886	DNA topoisomerase 4 subunit A	parC	0.0223
6226	DNA topoisomerase 4 subunit A	parC	0.0223
275	Arachidonate 5-lipoxygenase	ALOX5	0.0222
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0221
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.022
404	DNA gyrase subunit A	gyrA	0.0219
6224	DNA gyrase subunit A	gyrA	0.0219
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0218
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0216
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0214
891	Dihydropteroate synthase	folP	0.0212
5359	Dihydropteroate synthase	folP	0.0212
7175	Dihydropteroate synthase	sulI	0.0212
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
373	Transthyretin	TTR	0.021
629	Alpha-2B adrenergic receptor	ADRA2B	0.0208
161	Tubulin beta chain	TUBB	0.0206
312	Tubulin beta chain	TUB2	0.0206
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0206
232	Corticosteroid-binding globulin	SERPINA6	0.0206
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0205
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0201
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0199
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0199
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0198
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0196
1629	Transcription factor AP-1	JUN	0.0195
319	Opioid receptor, sigma 1	OPRS1	0.0195
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0193
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0192
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0192
273	Apoptosis regulator Bcl-2	BCL2	0.0192
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0192
378	Alpha-2C adrenergic receptor	ADRA2C	0.0191
758	Thyroid hormone receptor alpha	THRA	0.0188
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0186
432	D(4) dopamine receptor	DRD4	0.0186
244	Angiotensin-converting enzyme	ACE	0.0184
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0184
124	Histamine H2 receptor	HRH2	0.0184
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0183
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0183
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0183
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0183
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0183
723	Cytosolic phospholipase A2	PLA2G4A	0.0182
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0182
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0181
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.018
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0179
6138	Multidrug resistance protein 3	ABCB4	0.0179
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0179
1010	Cytochrome P450 51A1	CYP51A1	0.0178
777	Tumor necrosis factor	TNF	0.0175
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0174
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0173
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0173
3809	Estrogen-related receptor gamma	ESRRG	0.0171
3233	Bile acid receptor	NR1H4	0.0171
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.017
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0168
346	Thyroid hormone receptor beta-1	THRB	0.0167
818	50S ribosomal protein L10	rplJ	0.0167
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0167
2539	Tubulin alpha-1 chain	TUBA4A	0.0166
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0166
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0164
267	Plasminogen activator inhibitor 1	SERPINE1	0.0162
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0162
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0161
1757	Myeloperoxidase	MPO	0.0161
594	Thyroxine-binding globulin	SERPINA7	0.0161
13	Aminomethyltransferase, mitochondrial	AMT	0.0161
1656	CYP2B protein	CYP2B	0.016
716	5-hydroxytryptamine 7 receptor	HTR7	0.016
6167	Organic solute transporter subunit beta	OSTB	0.016
6166	Organic solute transporter subunit alpha	OSTA	0.0159
365	Dihydrofolate reductase	DHFR	0.0157
2381	Dihydrofolate reductase	DFR1	0.0157
2833	Dihydrofolate reductase	Not Available	0.0157
2931	Dihydrofolate reductase	folA	0.0157
3544	Dihydrofolate reductase	folA	0.0157
3682	Dihydrofolate reductase	folA	0.0157
6642	Dihydrofolate reductase	folA	0.0157
6756	Dihydrofolate reductase	dfrA	0.0157
94	5-hydroxytryptamine 4 receptor	HTR4	0.0154
427	Substance-P receptor	TACR1	0.0154
165	FL cytokine receptor	FLT3	0.0154
1192	Sulfotransferase 1A1	SULT1A1	0.0152
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0149
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0149
2021	Thrombomodulin	THBD	0.0149
1353	DNA topoisomerase 1	TOP1	0.0148
3552	DNA topoisomerase 1	topA	0.0148
6221	Steroid hormone receptor ERR1	ESRRA	0.0148
459	Retinoic acid receptor RXR-alpha	RXRA	0.0146
24	Thymidylate synthase	TMP1	0.0146
359	Thymidylate synthase	TYMS	0.0146
2626	Thymidylate synthase	thyA	0.0146
2729	Thymidylate synthase	thyA	0.0146
5352	Thymidylate synthase	THYA	0.0146
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0145
469	Annexin A1	ANXA1	0.0145
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
174	Sigma 1-type opioid receptor	SIGMAR1	0.0143
3947	Xanthine dehydrogenase/oxidase	XDH	0.0142
6020	Aldehyde oxidase	AOX1	0.0142
131	Synaptic vesicular amine transporter	SLC18A2	0.0139
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0138
474	Acetylcholinesterase	ACHE	0.0137
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0137
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0135
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0135
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0131
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0131
2808	Chloramphenicol acetyltransferase 3	cat3	0.013
768	FK506-binding protein 1A	FKBP1A	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
4237	50S ribosomal protein L22	rplV	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0125
54	Prothrombin	F2	0.0124
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0123
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0122
1852	Microtubule-associated protein 2	MAP2	0.0122
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0121
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0121
3856	Fibroblast growth factor receptor 3	FGFR3	0.012
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.012
705	Glutamate receptor 1	GRIA1	0.0118
4238	50S ribosomal protein L4	rplD	0.0118
5578	50S ribosomal protein L4	rplD	0.0118
6173	50S ribosomal protein L4	rplD	0.0118
6219	50S ribosomal protein L4	rplD	0.0118
6014	Cytochrome P450 2A13	CYP2A13	0.0118
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0117
908	Glutathione S-transferase theta-1	GSTT1	0.0116
284	DNA-directed RNA polymerase beta chain	rpoB	0.0116
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
163	D(1B) dopamine receptor	DRD5	0.0114
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0113
84	Nuclear receptor 0B1	NR0B1	0.0113
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0112
1618	High affinity nerve growth factor receptor	NTRK1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
1050	Bile salt sulfotransferase	SULT2A1	0.0111
1256	5-hydroxytryptamine 6 receptor	HTR6	0.011
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
2443	Azurin	azu	0.0108
5300	Antigen peptide transporter 1	TAP1	0.0108
295	Carbonic anhydrase 1	CA1	0.0108
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0107
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0107
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0106
6043	Putative G-protein coupled receptor 44	GPR44	0.0106
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0105
823	Fibroblast growth factor receptor 2	FGFR2	0.0105
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0105
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0105
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0105
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0104
5923	Microtubule-associated protein tau	MAPT	0.0104
5924	Microtubule-associated protein 4	MAP4	0.0104
1792	Tissue-type plasminogen activator	PLAT	0.0102
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0102
482	Glycine receptor subunit alpha-1	GLRA1	0.0101
6149	Solute carrier family 22 member 10	SLC22A10	0.0101
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0101
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0101
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0101
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0099
1517	Beta-3 adrenergic receptor	ADRB3	0.0099
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0099
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0099
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0098
921	Glutamate receptor 2	GRIA2	0.0098
1039	Histone deacetylase 9	HDAC9	0.0098
199	Monocarboxylate transporter 8	SLC16A2	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0096
4203	Histamine N-methyltransferase	HNMT	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
558	Solute carrier family 12 member 1	SLC12A1	0.0095
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0095
563	Thyroid peroxidase	TPO	0.0095
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0094
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0094
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0093
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0092
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0092
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0091
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0091
6146	High affinity copper uptake protein 1	SLC31A1	0.0091
611	Retinal dehydrogenase 1	ALDH1A1	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
976	Platelet glycoprotein IX	GP9	0.0089
4192	DNA topoisomerase 2-beta	TOP2B	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0088
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0088
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0088
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0087
3932	Glutathione S-transferase A2	GSTA2	0.0087
357	Carbonic anhydrase 2	CA2	0.0086
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0085
88	Retinoic acid receptor RXR-beta	RXRB	0.0085
1178	Adenosine A2a receptor	ADORA2A	0.0085
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0085
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0085
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0084
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0084
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0083
6042	Prostaglandin reductase 2	PTGR2	0.0083
814	Ryanodine receptor 1	RYR1	0.0083
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0083
4773	Deoxycytidine kinase	DCK	0.0082
751	Potassium channel subfamily K member 6	KCNK6	0.0082
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0081
239	Coagulation factor X	F10	0.0081
5787	Angiopoietin-1 receptor	TEK	0.008
1196	Complement decay-accelerating factor	CD55	0.008
1275	Estrogen sulfotransferase	SULT1E1	0.008
2449	Tubulin alpha-3 chain	TUBA1A	0.008
1525	Heparin-binding growth factor 2	FGF2	0.008
2636	Shikimate dehydrogenase	aroE	0.0079
3515	Shikimate dehydrogenase	aroE	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0079
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0078
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
7	Nitric oxide synthase, inducible	NOS2	0.0078
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
172	Potassium channel subfamily K member 1	KCNK1	0.0075
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0075
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0074
1541	Metalloproteinase	mmp20	0.0074
4217	Telomerase reverse transcriptase	TERT	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0073
6174	50S ribosomal protein L32	rpmF	0.0071
856	Vitamin D3 receptor	VDR	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
537	ATP synthase delta chain, mitochondrial	ATP5D	0.007
780	Retinoic acid receptor RXR-gamma	RXRG	0.007
1650	Heme carrier protein 1	SLC46A1	0.0069
1313	Lactoylglutathione lyase	GLO1	0.0069
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0068
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0068
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
16	Adenosine A1 receptor	ADORA1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
5934	Cytochrome P450 26A1	CYP26A1	0.0068
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
6432	Transporter	snf	0.0067
6151	Monocarboxylate transporter 10	SLC16A10	0.0067
936	Ephrin type-A receptor 2	EPHA2	0.0067
4311	tRNA	TRDMT1	0.0067
4325	tRNA	trmD	0.0067
4328	tRNA	trmD	0.0067
183	Vascular endothelial growth factor A	VEGFA	0.0066
5669	50S ribosomal protein L27	rpmA	0.0066
5675	Chaperone protein torD	torD	0.0065
5670	Organic hydroperoxide resistance protein	ohr	0.0065
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0065
5410	Unsaturated glucuronyl hydrolase	ugl	0.0065
5676	Axin-1	AXIN1	0.0065
5673	C protein alpha-antigen	bca	0.0065
581	Cytochrome P450 2R1	CYP2R1	0.0065
5798	Mitogen-activated protein kinase 11	MAPK11	0.0065
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0063
133	Dihydropterate synthase	sulI	0.0063
3270	Elongation factor G	fusA	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0062
896	Glutathione S-transferase Mu 1	GSTM1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
6163	Copper-transporting ATPase 2	ATP7B	0.0061
6165	Copper-transporting ATPase 1	ATP7A	0.0061
153	Dopamine beta-hydroxylase	DBH	0.0061
1291	cAMP response element-binding protein	CREB1	0.0061
760	Fibroblast growth factor 1	FGF1	0.0061
162	Retinoic acid receptor gamma-1	RARG	0.006
518	Peroxidase/catalase T	katG	0.006
6126	Carbonic anhydrase 7	CA7	0.006
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0059
6033	High affinity interleukin-8 receptor A	CXCR1	0.0059
2232	Interleukin-5	IL5	0.0059
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0059
1593	Mucin-2	MUC2	0.0059
4210	Toll-like receptor 4	TLR4	0.0059
4103	Proteasome subunit beta type 2	PSMB2	0.0059
4102	Proteasome subunit beta type 5	PSMB5	0.0059
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0059
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0059
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0059
4101	Proteasome subunit beta type 1	PSMB1	0.0059
2285	Streptogramin A acetyltransferase	vatD	0.0059
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0058
909	Maleylacetoacetate isomerase	GSTZ1	0.0058
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0058
2320	Thymidine kinase, cytosolic	TK1	0.0057
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0057
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
3191	Histidinol dehydrogenase	hisD	0.0057
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0057
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0057
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0057
3937	Fatty-acid amide hydrolase	FAAH	0.0055
6506	Stathmin-4	STMN4	0.0055
489	Monocarboxylate transporter 2	SLC16A7	0.0054
461	Glycine receptor subunit alpha-3	GLRA3	0.0054
5626	Nucleoside diphosphate kinase B	NME2	0.0054
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0053
6168	Solute carrier family 22 member 16	SLC22A16	0.0053
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0053
4811	Amylosucrase	ams	0.0053
2280	Listeriolysin regulatory protein	prfA	0.0052
551	Carnitine O-acetyltransferase	CRAT	0.0052
1262	Corticotropin-lipotropin	POMC	0.0052
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0052
191	Peptide methionine sulfoxide reductase	MSRA	0.0052
1992	Vitamin D-binding protein	GC	0.0052
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
6218	Pannexin-1	PANX1	0.0051
5294	Nucleoside diphosphate kinase A	NME1	0.0051
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0051
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
444	Alcohol dehydrogenase 1B	ADH1B	0.0051
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.005
517	Alcohol dehydrogenase 1C	ADH1C	0.005
569	Retinal dehydrogenase 2	ALDH1A2	0.005
6048	Troponin C, skeletal muscle	TNNC2	0.005
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0049
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0049
719	Retinoic acid receptor responder protein 1	RARRES1	0.0049
1123	Eosinophil cationic protein	RNASE3	0.0049
770	Retinoic acid-induced protein 3	GPRC5A	0.0049
173	Toll-like receptor 7	TLR7	0.0049
634	Squalene monooxygenase	SQLE	0.0049
7196	Squalene monooxygenase	ERG1	0.0049
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0047
4692	A/G-specific adenine glycosylase	mutY	0.0047
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0047
2159	Quinone oxidoreductase	CRYZ	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1648	Elastin	ELN	0.0046
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0045
6211	Tubulin epsilon chain	TUBE1	0.0045
6210	Tubulin delta chain	TUBD1	0.0045
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0045
6212	Tubulin gamma-1 chain	TUBG1	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
2599	Tyrosine-protein kinase HCK	HCK	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0043
5818	Folate receptor alpha	FOLR1	0.0043
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
2391	Ferrochelatase	hemH	0.0041
6502	Ferrochelatase	DKFZp686P18130	0.0041
1591	Ferrochelatase, mitochondrial	FECH	0.0041
1864	RET proto-oncogene	RET	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0041
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0041
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
702	UMP-CMP kinase	CMPK1	0.004
2314	Triosephosphate isomerase	TPI	0.004
3417	Triosephosphate isomerase	tpiA	0.004
3443	Triosephosphate isomerase	tpiA	0.004
6346	Triosephosphate isomerase	TPI1	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
2371	Pantothenate kinase	coaA	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
164	Histamine H4 receptor	HRH4	0.0038
85	Growth hormone receptor	GHR	0.0038
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0037
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0037
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
293	Gamma-glutamyl hydrolase	GGH	0.0037
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0037
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0037
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0037
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0036
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0036
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0036
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0036
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0036
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0036
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0036
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0036
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0036
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0036
4564	YvbK protein	yvbK	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0036
6559	Cytochrome c oxidase subunit 2	ctaC	0.0036
6669	Cytochrome c oxidase subunit 2	ctaC	0.0036
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0036
4567	Putative acyl-CoA thioester hydrolase HI0827	HI_0827	0.0036
4566	Acyl-CoA hydrolase	BC_2038	0.0036
4572	Acyl-CoA hydrolase	BH0798	0.0036
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0036
6558	Cytochrome c oxidase subunit 1	ctaD	0.0036
4576	Aac(6')-Ii protein	aac(6')-Ii	0.0036
4577	4'-phosphopantetheinyl transferase sfp	sfp	0.0036
2528	Fatty acid metabolism regulator protein	fadR	0.0036
6740	Fatty acid metabolism regulator protein	fadR	0.0036
4579	Serine acetyltransferase	cysE	0.0036
6807	Serine acetyltransferase	cysE	0.0036
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0036
6837	Serine/threonine-protein kinase 17B	STK17B	0.0036
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
251	Alcohol dehydrogenase 1A	ADH1A	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
939	50S ribosomal protein L3	rplC	0.0035
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0035
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0035
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0034
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0034
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0034
76	Nitric-oxide synthase, brain	NOS1	0.0034
291	Nitric-oxide synthase, endothelial	NOS3	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0034
1714	Mitogen-activated protein kinase 3	MAPK3	0.0034
2540	Choloylglycine hydrolase	cbh	0.0033
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0031
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0031
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0031
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0031
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0031
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
3489	Acetyl-coenzyme A synthetase	acs	0.0031
2396	Formyl-coenzyme A transferase	frc	0.0031
3457	Formyl-coenzyme A transferase	frc	0.0031
4574	PROBABLE NAPHTHOATE SYNTHASE MENB	menB	0.0031
3024	Crotonobetainyl-CoA:carnitine CoA-transferase	caiB	0.0031
3729	Citrate synthase	gltA	0.0031
4575	Citrate synthase	cit	0.0031
4580	Citrate synthase	gltA	0.0031
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0031
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0031
4563	Acetyl transferase	rimL	0.0031
4565	Aminoglycoside 6'-N-acetyltransferase	aac(6')-Iy	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
6501	Fatty acid-binding protein, liver	FABP1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
4573	Histone acetyltransferase PCAF	KAT2B	0.0029
2377	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Not Available	0.0029
2560	Galactoside O-acetyltransferase	lacA	0.0029
3199	Phosphopantetheine adenylyltransferase	coaD	0.0029
3543	Phosphopantetheine adenylyltransferase	coaD	0.0029
3567	Phosphopantetheine adenylyltransferase	coaD	0.0029
5289	Phosphopantetheine adenylyltransferase	coaD	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
663	Solute carrier family 12 member 4	SLC12A4	0.0029
53	Solute carrier family 12 member 5	SLC12A5	0.0029
2248	Malate synthase G	glcB	0.0028
3190	Malate synthase G	glcB	0.0028
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0028
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
3178	Formate acetyltransferase 1	pflB	0.0028
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0028
666	NADP-dependent malic enzyme	ME1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0028
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
484	Tyrosine-protein kinase ABL2	ABL2	0.0027
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0027
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0027
340	Apoptotic protease-activating factor 1	APAF1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
4404	FcbC1 protein	fcbC	0.0027
2207	Rhodopsin	RHO	0.0027
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
310	Solute carrier family 12 member 2	SLC12A2	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
473	L-lactate dehydrogenase A chain	LDHA	0.0026
2376	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6500	Phospholipase A2	PLA2G1B	0.0026
992	Protein tyrosine kinase 2 beta	PTK2B	0.0026
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
5322	Oxidoreductase ydhF	ydhF	0.0025
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0025
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0025
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0025
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0025
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0025
3639	Thymidine phosphorylase	deoA	0.0025
3936	Thymidine phosphorylase	TYMP	0.0025
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0025
5332	MtdA bifunctional protein	mtdA	0.0025
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0025
4403	Protein iolS	iolS	0.0025
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0025
5330	General stress protein 69	yhdN	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0025
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
3957	Adenosine deaminase	ADA	0.0024
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0024
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
615	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
3138	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
4568	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
6370	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
2596	Acetyl-CoA acetyltransferase	phbA	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
654	Flavin reductase	BLVRB	0.0023
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0023
268	Adenosine A2b receptor	ADORA2B	0.0023
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
5073	Ferredoxin--NADP reductase	petH	0.0022
5076	Ferredoxin--NADP reductase	fpr	0.0022
5119	Ferredoxin--NADP reductase	petH	0.0022
5121	Ferredoxin--NADP reductase	fpr	0.0022
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0022
5328	Prostaglandin F synthase	Tb11.02.2310	0.0022
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0022
3446	NADP-dependent alcohol dehydrogenase	adh	0.0022
2286	Isocitrate dehydrogenase [NADP]	icd	0.0022
2302	Isocitrate dehydrogenase [NADP]	icd	0.0022
2771	Isocitrate dehydrogenase [NADP]	icd	0.0022
4582	Putative pteridine reductase 2	ptr2	0.0022
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0022
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0022
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
989	L-xylulose reductase	DCXR	0.0022
3404	Exotoxin A	eta	0.0022
298	Renin	REN	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6459	Glycodelin	PAEP	0.002
6297	Prostaglandin reductase 1	PTGR1	0.002
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.002
4531	Putative ketoacyl reductase	actIII	0.002
3062	Aspartate-semialdehyde dehydrogenase	asd	0.002
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
2675	Pteridine reductase 1	PTR1	0.0019
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
1124	Sepiapterin reductase	SPR	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
822	Aldose reductase	AKR1B1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
3830	Calreticulin	CALR	0.0017
5288	Shikimate kinase	aroK	0.0017
5287	Signaling protein	Not Available	0.0017
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0017
5293	Shikimate kinase 2	aroL	0.0017
5304	UPF0166 protein TM_0021	TM_0021	0.0017
4346	Polynucleotide kinase	pseT	0.0017
5292	Putative partitioning protein	TT_C1605	0.0017
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0017
5266	Activator of	hgdC	0.0017
5259	Transcriptional regulator	ntrC1	0.0017
6699	Transcriptional regulator	Cgl2612	0.0017
2874	Nitrogenase iron protein 1	nifH1	0.0017
5283	D-alanine--D-alanine ligase B	ddlB	0.0017
5281	Plasmid segregation protein parM	parM	0.0017
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0017
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0017
5299	D-alanine--D-alanine ligase	ddl	0.0017
6598	D-alanine--D-alanine ligase	ddl	0.0017
5315	Chaperone protein htpG	htpG	0.0017
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0017
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0017
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0017
5291	Glycogen synthase 1	glgA1	0.0017
5264	DNA replication protein	REP	0.0017
5277	Preprotein translocase subunit secA	secA	0.0017
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0017
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0017
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0017
5284	Large T antigen	Not Available	0.0017
5308	Preprotein translocase secA 1 subunit	secA1	0.0017
5285	Kinesin heavy chain	KIF5B	0.0017
2091	Endoplasmin	HSP90B1	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0016
4041	Microsomal glutathione S-transferase 2	MGST2	0.0016
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0016
4226	Uridine phosphorylase 2	UPP2	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0016
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
207	Glutathione synthetase	GSS	0.0015
5269	Glutathione synthetase	gshB	0.0015
4225	Uridine phosphorylase 1	UPP1	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
3221	Cytochrome c4	cc4	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
4106	Guanylate kinase	GUK1	0.0013
4516	Guanylate kinase	gmk	0.0013
4837	Cag-alfa	cag-alfa	0.0013
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0013
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0013
5646	Galactokinase	GALK1	0.0013
4838	PMS1 protein homolog 2	PMS2	0.0013
4839	DNA polymerase III subunit tau	dnaX	0.0013
5302	TrwB	trwB	0.0013
5265	FtsH	ftsH	0.0013
5189	Trimethylamine dehydrogenase	tmd	0.0013
4774	NTPase P4	Not Available	0.0013
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0013
2270	Dephospho-CoA kinase	coaE	0.0013
2284	Adenylate kinase	adk	0.0013
2296	Adenylate kinase	adk	0.0013
2311	Adenylate kinase	adk	0.0013
2312	Adenylate kinase	Not Available	0.0013
3470	Hypothetical protein MG245 homolog	MPN_348	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
3175	Glutamate--cysteine ligase	gshA	0.0013
3426	Glutamine synthetase	glnA	0.0013
3987	Glutamine synthetase	GLUL	0.0013
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0013
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0013
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2683	Mono-ADP-ribosyltransferase C3	C3	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
292	Activin receptor type-1	ACVR1	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
2390	Nonsecretory ribonuclease	RNASE2	0.0012
5312	Kinesin-like protein KIF1A	KIF1A	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
2922	Glycerol kinase	glpK	0.0012
5271	Focal adhesion kinase 1	PTK2	0.0012
6859	Protein S100-A4	S100A4	0.0012
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
2282	Protein recA	recA	0.0011
2315	Protein recA	recA	0.0011
2332	Protein recA	recA	0.0011
5263	Protein recA	recA	0.0011
408	Riboflavin kinase	RFK	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2615	Chemotaxis protein cheA	cheA	0.0011
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0011
1881	Hexokinase-1	HK1	0.0011
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0011
2892	Acetylglutamate kinase	argB	0.0011
3550	Acetylglutamate kinase	argB	0.0011
3669	Ribokinase	rbsK	0.0011
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.001
788	Creatine kinase M-type	CKM	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2727	S-adenosylmethionine synthetase	metK	0.001
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2334	Dethiobiotin synthetase	bioD	0.001
6555	Dethiobiotin synthetase	bioD	0.001
2697	Uridine-cytidine kinase 2	UCK2	0.001
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
810	Heme oxygenase 1	HMOX1	0.001
3391	Heme oxygenase 1	pbsA1	0.001
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.001
2298	Cytochrome P450-cam	camC	0.001
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
48	Pyridoxal kinase	PDXK	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6395	Myosin-14	MYH14	0.0009
2251	Thymidylate kinase	tmk	0.0009
2254	Thymidylate kinase	DTYMK	0.0009
3522	Thymidylate kinase	tmk	0.0009
816	Biliverdin reductase A	BLVRA	0.0009
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0009
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0009
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
1422	Serine/threonine-protein kinase 6	AURKA	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
3379	Kinesin-like protein KIF11	KIF11	0.0008
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0008
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0008
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0008
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0008
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0008
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0008
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0008
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0008
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0008
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0008
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0008
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0008
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0008
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0008
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0008
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0008
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0008
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0008
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0008
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0008
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0008
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0008
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0008
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0008
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0008
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0008
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0008
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0008
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0008
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0008
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0008
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0008
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0008
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0008
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0008
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0008
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0008
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0008
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0008
107	C-4 methylsterol oxidase	SC4MOL	0.0008
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0008
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0008
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0008
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0008
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0008
729	GDP-L-fucose synthetase	TSTA3	0.0008
3463	GDP-L-fucose synthetase	fcl	0.0008
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0008
167	L-lactate dehydrogenase C chain	LDHC	0.0008
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0008
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0008
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0008
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0008
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0008
206	3-keto-steroid reductase	HSD17B7	0.0008
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0008
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0008
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0008
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0008
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0008
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0008
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0008
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0008
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0008
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0008
34	7-dehydrocholesterol reductase	DHCR7	0.0008
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0008
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0008
711	UDP-glucose 6-dehydrogenase	UGDH	0.0008
3672	UDP-glucose 6-dehydrogenase	hasB	0.0008
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0008
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0008
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0008
643	Peroxisomal bifunctional enzyme	EHHADH	0.0008
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0008
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0008
3822	Actin, alpha skeletal muscle	ACTA1	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0008
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0008
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0008
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0008
396	Alcohol dehydrogenase 4	ADH4	0.0008
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0008
328	Sorbitol dehydrogenase	SORD	0.0008
597	Dihydropteridine reductase	QDPR	0.0008
1867	Major prion protein	PRNP	0.0008
857	Malate dehydrogenase, mitochondrial	MDH2	0.0008
1507	Cytochrome c	CYCS	0.0008
509	Thymidine kinase	TK	0.0008
570	Thymidine kinase	TK	0.0008
2559	Thymidine kinase	TK	0.0008
3430	Thymidine kinase	tdk	0.0008
3518	Thymidine kinase	TK	0.0008
5301	Thymidine kinase	tdk	0.0008
5771	Thymidine kinase	ORF36	0.0008
7009	Thymidine kinase	ORF36	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0008
1025	Aquaporin-1	AQP1	0.0008
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0008
12	Alcohol dehydrogenase class 3	ADH5	0.0008
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0008
77	L-lactate dehydrogenase B chain	LDHB	0.0008
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0007
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0007
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0007
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0007
626	Cysteine dioxygenase type 1	CDO1	0.0007
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0007
5682	Ribonuclease pancreatic	RNASE1	0.0007
627	11-cis retinol dehydrogenase	RDH5	0.0007
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
125	DNA polymerase beta	POLB	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
279	Tyrosinase	TYR	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00641 - Simvastatin

Targets

Enzymes

Transporters

Predictions