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MTA/SAH nucleosidase


Partner ID 3679
Name MTA/SAH nucleosidase
Synonyms 5690
Gene name mtnN
General function Nucleotide transport and metabolism
Specific function Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH)
Gene sequence + ...

ATGAAAATCGGCATCATTGGTGCAATGGAAGAAGAAGTTACGCTGCTGCGTGACAAAATCGAAAACCGTCAAACTATCAGTCTCGGCGGTTGCGAAATCTATACCGGCCAACTGAATGGAACCGAGGTTGCGCTTCTGAAATCGGGCATCGGTAAAGTCGCTGCGGCGCTGGGTGCCACTTTGCTGTTGGAACACTGCAAGCCAGATGTGATTATTAACACCGGTTCTGCCGGTGGCCTGGCACCAACGTTGAAAGTGGGCGATATCGTTGTCTCGGACGAAGCACGTTATCACGACGCGGATGTCACGGCATTTGGTTATGAATACGGTCAGTTACCAGGCTGTCCGGCAGGCTTTAAAGCTGACGATAAACTGATCGCTGCCGCTGAGGCCTGCATTGCCGAACTGAATCTTAACGCTGTACGTGGCCTGATTGTTAGCGGCGACGCTTTCATCAACGGTTCTGTTGGTCTGGCGAAAATCCGCCACAACTTCCCACAGGCCATTGCTGTAGAGATGGAAGCGACGGCAATCGCCCATGTCTGCCACAATTTCAACGTCCCGTTTGTTGTCGTACGCGCCATCTCCGACGTGGCCGATCAACAGTCTCATCTTAGCTTCGATGAGTTCCTGGCTGTTGCCGCTAAACAGTCCAGCCTGATGGTTGAGTCACTGGTGCAGAAACTTGCACATGGCTAA
Protein sequence + ...

MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
GO Classification
function
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
methylthioadenosine nucleosidase activity
catalytic activity
adenosylhomocysteine nucleosidase activity
hydrolase activity
process
nucleoside metabolism
sulfur amino acid metabolism
methionine metabolism
physiological process
metabolism
methionine salvage
cellular metabolism
nucleoside catabolism
amino acid metabolism
amino acid and derivative metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00173 Adenine
DB02158 (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol
DB02281 Formycin
DB02933 5'-Deoxy-5'-(Methylthio)-Tubercidin
DB08606 (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL

Associated as Prediction

Id Name
DB00121 Biotin
DB00131 Adenosine monophosphate
DB00173 Adenine
DB00197 Troglitazone
DB00227 Lovastatin
DB00295 Morphine
DB00316 Acetaminophen
DB00328 Indomethacin
DB00398 Sorafenib
DB00530 Erlotinib
DB00586 Diclofenac
DB00641 Simvastatin
DB00678 Losartan
DB00688 Mycophenolate mofetil
DB00704 Naltrexone
DB00712 Flurbiprofen
DB00762 Irinotecan
DB00773 Etoposide
DB00783 Estradiol
DB00788 Naproxen
DB00818 Propofol
DB00870 Suprofen
DB00973 Ezetimibe
DB01024 Mycophenolic acid
DB01045 Rifampin
DB01048 Abacavir
DB01050 Ibuprofen
DB01076 Atorvastatin
DB01095 Fluvastatin
DB01420 Testosterone Propionate
DB01544 Flunitrazepam
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01688 P-Cresol
DB01726 2-Aminophenol
DB02030 Alpha-Ribazole-5'-Phosphate
DB02158 (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol
DB02163 2,5-Xylidine
DB02168 Bromopurine
DB02281 Formycin
DB02282 5'-Deoxy-5'-Methylthioadenosine
DB02379 Beta-D-Glucose
DB02382 Namn
DB02591 5,6-Dimethylbenzimidazole
DB02733 Purvalanol
DB02753 Selenoinosine
DB02770 7-Alpha-D-Ribofuranosyl-2-Aminopurine-5'-Phosphate
DB02819 Mono-[3,4-Dihydroxy-5-(5-Methyl-Benzoimidazol-1-Yl)-Tetrahydor-Furan-2-Ylmethyl] Ester
DB02859 Soraphen A
DB02905 Phosphoric Acid Mono-[3,4-Dihydroxy-5-(5-Hydroxy-Benzoimidazol-1-Yl)Tetrahydro-Furan-2-Ylmethyl] Ester
DB02933 5'-Deoxy-5'-(Methylthio)-Tubercidin
DB02962 Benzimidazole
DB03018 3,4-Dimethylaniline
DB03079 Alpha-Ribazole-5'-Phosphate Derivative
DB03177 5-methylbenzimidazole
DB03180 4,5-Dimethyl-1,2-Phenylenediamine
DB03200 7-Alpha-D-Ribofuranosyl-Purine-5'-Phosphate
DB03255 Phenol
DB03371 Modified Ribosylated Glutamyl Ester
DB03431 Adenosine-5'-Diphosphate
DB03506 9-Deazaadenine
DB03781 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid
DB03887 Alpha-Adenosine Monophosphate
DB04052 3,4-Dimethylphenol
DB04077 Glycerol
DB04120 4-Methyl-1,2-Benzenediol
DB04130 5-Methoxybenzimidazole
DB04176 Phosporic Acid Mono-[3,4-Dihydroxy-5-(5-Methoxy-Benzoimidazol-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester
DB04214 4-Nitrophenyl Phosphate
DB04272 Citric Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04532 Indole
DB04533 2-Amino-P-Cresol
DB04868 Nilotinib
DB04953 Ezogabine
DB05039 Indacaterol
DB06210 Eltrombopag
DB06589 Pazopanib
DB06626 Axitinib
DB07870 (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID
DB08606 (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL
DB08896 Regorafenib
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