DT-Web

DB00704 - Naltrexone


Identification
Name Naltrexone
Accession Number DB00704 (APRD00005, DB05067)
Type small molecule
Description Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 341.4009
Groups approved
Monoisotopic Weight 341.162708229
Pharmacology
Indication Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
Mechanism of action Naltrexone is a pure opiate antagonist and has little or no agonist activity. The mechanism of action of naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Naltrexone is thought to act as a competitive antagonist at mc, ?, and ? receptors in the CNS, with the highest affintiy for the ? receptor. Naltrexone competitively binds to such receptors and may block the effects of endogenous opioids. This leads to the antagonization of most of the subjective and objective effects of opiates, including respiratory depression, miosis, euphoria, and drug craving. The major metabolite of naltrexone, 6-?-naltrexol, is also an opiate antagonist and may contribute to the antagonistic activity of the drug.
Absorption Although well absorbed orally, naltrexone is subject to significant first pass metabolism with oral bioavailability estimates ranging from 5 to 40%.
Protein binding 21% bound to plasma proteins over the therapeutic dose range.
Biotransformation Hepatic. When administered orally, naltrexone undergoes extensive biotransformation and is metabolized to 6 beta-naltrexol (which may contribute to the therapeutic effect) and other minor metabolites.
Route of elimination Both parent drug and metabolites are excreted primarily by the kidney (53% to 79% of the dose), however, urinary excretion of unchanged naltrexone accounts for less than 2% of an oral dose and fecal excretion is a minor elimination pathway. The renal clearance for naltrexone ranges from 30 to 127 mL/min and suggests that renal elimination is primarily by glomerular filtration.
Toxicity In the mouse, rat and guinea pig, the oral LD50s were 1,100-1,550 mg/kg; 1,450 mg/kg; and 1,490 mg/kg; respectively. High doses of naltrexone (generally ≥1,000 mg/kg) produce salivation, depression/reduced activity, tremors, and convulsions.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals.

Targets


Delta-type opioid receptor
Name Delta-type opioid receptor
Gene Name OPRD1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Roy S, Guo X, Kelschenbach J, Liu Y, Loh HH: In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance. J Neurosci. 2005 Mar 23;25(12):3229-33. - Pubmed
  • Barrios de Tomasi E, Juarez-Gonzalez J: [Opioid antagonists and alcohol consumption] Rev Neurol. 2007 Aug 1-15;45(3):155-62. - Pubmed
  • Weerts EM, Kim YK, Wand GS, Dannals RF, Lee JS, Frost JJ, McCaul ME: Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacology. 2008 Feb;33(3):653-65. Epub 2007 May 9. - Pubmed
  • Herz A: Opioid reward mechanisms: a key role in drug abuse? Can J Physiol Pharmacol. 1998 Mar;76(3):252-8. - Pubmed
  • Herz A: Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl). 1997 Jan;129(2):99-111. - Pubmed
DTHybrid score 0.8593
Mu-type opioid receptor
Name Mu-type opioid receptor
Gene Name OPRM1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kato H: [Pharmacological effects of a mu-opioid receptor antagonist naltrexone on alcohol dependence] Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008 Oct;43(5):697-704. - Pubmed
  • Helm S, Trescot AM, Colson J, Sehgal N, Silverman S: Opioid antagonists, partial agonists, and agonists/antagonists: the role of office-based detoxification. Pain Physician. 2008 Mar-Apr;11(2):225-35. - Pubmed
  • Goodman AJ, Le Bourdonnec B, Dolle RE: Mu opioid receptor antagonists: recent developments. ChemMedChem. 2007 Nov;2(11):1552-70. - Pubmed
  • Barrios de Tomasi E, Juarez-Gonzalez J: [Opioid antagonists and alcohol consumption] Rev Neurol. 2007 Aug 1-15;45(3):155-62. - Pubmed
  • Weerts EM, Kim YK, Wand GS, Dannals RF, Lee JS, Frost JJ, McCaul ME: Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacology. 2008 Feb;33(3):653-65. Epub 2007 May 9. - Pubmed
  • Herz A: Opioid reward mechanisms: a key role in drug abuse? Can J Physiol Pharmacol. 1998 Mar;76(3):252-8. - Pubmed
DTHybrid score 1.0306
Kappa-type opioid receptor
Name Kappa-type opioid receptor
Gene Name OPRK1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Helm S, Trescot AM, Colson J, Sehgal N, Silverman S: Opioid antagonists, partial agonists, and agonists/antagonists: the role of office-based detoxification. Pain Physician. 2008 Mar-Apr;11(2):225-35. - Pubmed
  • Herz A: Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl). 1997 Jan;129(2):99-111. - Pubmed
  • Barrios de Tomasi E, Juarez-Gonzalez J: [Opioid antagonists and alcohol consumption] Rev Neurol. 2007 Aug 1-15;45(3):155-62. - Pubmed
  • Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF: Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl). 2009 Sep;205(4):565-75. Epub 2009 May 30. - Pubmed
DTHybrid score 0.8354
Opioid receptor, sigma 1
Name Opioid receptor, sigma 1
Gene Name OPRS1
Pharmacological action yes
Actions antagonist
References
  • Helm S, Trescot AM, Colson J, Sehgal N, Silverman S: Opioid antagonists, partial agonists, and agonists/antagonists: the role of office-based detoxification. Pain Physician. 2008 Mar-Apr;11(2):225-35. - Pubmed
  • Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF: Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl). 2009 Sep;205(4):565-75. Epub 2009 May 30. - Pubmed
  • Herz A: Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl). 1997 Jan;129(2):99-111. - Pubmed
DTHybrid score 0.2605

Enzymes


UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Antonilli L, Brusadin V, Milella MS, Sobrero F, Badiani A, Nencini P: In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat. Biochem Pharmacol. 2008 Sep 1;76(5):672-9. Epub 2008 Jul 1. - Pubmed
DTHybrid score 0.2333

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.3286

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2211
4119 Cytochrome P450 2D6 CYP2D6 0.1689
1716 Tripartite motif-containing protein 13 TRIM13 0.115
4118 Cytochrome P450 3A5 CYP3A5 0.1134
4924 Cytochrome P450 2C8 CYP2C8 0.1122
6107 Cytochrome P450 3A7 CYP3A7 0.1077
4757 Cytochrome P450 2C9 CYP2C9 0.1004
1262 Corticotropin-lipotropin POMC 0.0841
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0781
6016 Cytochrome P450 2C19 CYP2C19 0.0772
174 Sigma 1-type opioid receptor SIGMAR1 0.0763
6030 Cytochrome P450 2B6 CYP2B6 0.0739
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0641
4200 Cytochrome P450 1A2 CYP1A2 0.0605
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0526
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0492
824 Sodium-dependent serotonin transporter SLC6A4 0.0487
587 Serum albumin ALB 0.0459
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0415
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0411
4137 Nociceptin receptor OPRL1 0.0389
6013 Cytochrome P450 2E1 CYP2E1 0.0386
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0381
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0361
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0328
20 Prostaglandin G/H synthase 1 PTGS1 0.0311
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0277
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0276
6026 Alcohol dehydrogenase 6 ADH6 0.0266
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0246
862 Multidrug resistance-associated protein 1 ABCC1 0.0244
6024 Cytochrome P450 1A1 CYP1A1 0.0241
1181 Alpha-1-acid glycoprotein 1 ORM1 0.023
5718 Cytochrome P450 2A6 CYP2A6 0.0225
290 Prostaglandin G/H synthase 2 PTGS2 0.0214
6145 Solute carrier family 22 member 1 SLC22A1 0.0199
1729 Solute carrier family 22 member 6 SLC22A6 0.0184
6106 Cytochrome P450 2C18 CYP2C18 0.0184
5838 Transient receptor potential cation channel subfamily V member 3 TRPV3 0.0176
2162 Transient receptor potential cation channel subfamily M member 8 TRPM8 0.0176
1944 Transient receptor potential cation channel subfamily A member 1 TRPA1 0.0176
1291 cAMP response element-binding protein CREB1 0.0175
341 5-hydroxytryptamine 3 receptor HTR3A 0.0169
136 Estrogen receptor ESR1 0.0164
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0161
4210 Toll-like receptor 4 TLR4 0.0158
26 Vascular endothelial growth factor receptor 3 FLT4 0.0154
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0154
3811 Cytochrome P450 19A1 CYP19A1 0.015
32 Vascular endothelial growth factor receptor 1 FLT1 0.0148
766 Beta-2 adrenergic receptor ADRB2 0.0146
465 Calmodulin CALM1 0.0144
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0143
590 5-hydroxytryptamine 2C receptor HTR2C 0.0143
504 Mast/stem cell growth factor receptor KIT 0.014
3810 Catechol O-methyltransferase COMT 0.0133
2164 Multidrug resistance-associated protein 4 ABCC4 0.0132
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0129
146 Androgen receptor AR 0.0128
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0128
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0127
556 Alpha-1A adrenergic receptor ADRA1A 0.0126
492 Histamine H1 receptor HRH1 0.0125
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0124
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0124
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0123
407 Vascular endothelial growth factor receptor 2 KDR 0.0122
5880 Thrombopoietin receptor MPL 0.012
776 Bile salt export pump ABCB11 0.0115
1898 Cytochrome P450 1B1 CYP1B1 0.0115
502 5-hydroxytryptamine 2A receptor HTR2A 0.0111
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.011
4604 Liver carboxylesterase 1 CES1 0.0107
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0106
4120 NADPH--cytochrome P450 reductase POR 0.0103
3923 Cholinesterase BCHE 0.0103
6142 Solute carrier family 22 member 8 SLC22A8 0.0099
871 Glucocorticoid receptor NR3C1 0.0099
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0098
6144 Solute carrier family 22 member 2 SLC22A2 0.0096
318 Alpha-2A adrenergic receptor ADRA2A 0.0093
320 5-hydroxytryptamine 1A receptor HTR1A 0.0093
193 Beta-1 adrenergic receptor ADRB1 0.0093
228 Beta platelet-derived growth factor receptor PDGFRB 0.0091
103 Muscarinic acetylcholine receptor M1 CHRM1 0.009
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0089
831 D(2) dopamine receptor DRD2 0.0087
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0086
817 DNA topoisomerase 2-alpha TOP2A 0.0083
844 Epidermal growth factor receptor EGFR 0.0082
1192 Sulfotransferase 1A1 SULT1A1 0.0082
6143 Solute carrier family 22 member 7 SLC22A7 0.0081
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0081
6137 Multidrug resistance-associated protein 6 ABCC6 0.008
1353 DNA topoisomerase 1 TOP1 0.0076
3552 DNA topoisomerase 1 topA 0.0076
1024 Solute carrier family 22 member 11 SLC22A11 0.0076
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0075
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0075
6102 Arylamine N-acetyltransferase 2 NAT2 0.0073
6148 Multidrug resistance-associated protein 7 ABCC10 0.0073
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0073
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0073
789 Alpha-1D adrenergic receptor ADRA1D 0.0073
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0071
617 Muscarinic acetylcholine receptor M2 CHRM2 0.007
6147 Solute carrier family 22 member 3 SLC22A3 0.0069
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0069
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0069
1618 High affinity nerve growth factor receptor NTRK1 0.0066
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0065
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
885 5-hydroxytryptamine 1B receptor HTR1B 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0061
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0061
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
6136 Multidrug resistance-associated protein 5 ABCC5 0.0058
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0058
632 Alpha-1B adrenergic receptor ADRA1B 0.0058
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0058
6141 Sodium/bile acid cotransporter SLC10A1 0.0056
1760 Aminopeptidase N ANPEP 0.0056
6843 Aminopeptidase N pepN 0.0056
118 Organic cation/carnitine transporter 2 SLC22A5 0.0055
117 Sterol O-acyltransferase 1 SOAT1 0.0055
70 Type-1 angiotensin II receptor AGTR1 0.0055
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
869 Estrogen receptor beta ESR2 0.0053
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0053
6085 Fatty acid-binding protein, intestinal FABP2 0.0052
6182 Cytochrome P450 2J2 CYP2J2 0.0052
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0052
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0051
952 Dipeptidyl peptidase 4 DPP4 0.005
2450 Tyrosine-protein kinase ITK/TSK ITK 0.005
731 HIV-1 protease HIV-1 protease 0.005
3856 Fibroblast growth factor receptor 3 FGFR3 0.0049
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0049
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0048
23 D(1A) dopamine receptor DRD1 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
4692 A/G-specific adenine glycosylase mutY 0.0047
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0046
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0045
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0045
124 Histamine H2 receptor HRH2 0.0044
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0044
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0044
756 Sex hormone-binding globulin SHBG 0.0043
1630 Integrin beta-2 ITGB2 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
4606 Purine trans deoxyribosylase ptd 0.0042
614 Progesterone receptor PGR 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
474 Acetylcholinesterase ACHE 0.004
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0039
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0039
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0037
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0036
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0036
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0036
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0036
468 Cytochrome P450 4A11 CYP4A11 0.0036
165 FL cytokine receptor FLT3 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
94 5-hydroxytryptamine 4 receptor HTR4 0.0035
2981 Phospholipase A2, membrane associated PLA2G2A 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
6044 Serum paraoxonase/lactonase 3 PON3 0.0035
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
373 Transthyretin TTR 0.0034
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0034
4192 DNA topoisomerase 2-beta TOP2B 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
811 Translocator protein TSPO 0.0034
2021 Thrombomodulin THBD 0.0034
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0033
3941 Amine oxidase [flavin-containing] A MAOA 0.0033
5798 Mitogen-activated protein kinase 11 MAPK11 0.0033
904 Glutathione S-transferase P GSTP1 0.0033
273 Apoptosis regulator Bcl-2 BCL2 0.0033
572 Integrin alpha-L ITGAL 0.0032
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0032
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0031
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0031
638 D(3) dopamine receptor DRD3 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
936 Ephrin type-A receptor 2 EPHA2 0.0031
908 Glutathione S-transferase theta-1 GSTT1 0.0031
1275 Estrogen sulfotransferase SULT1E1 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
4122 Histone deacetylase 2 HDAC2 0.003
760 Fibroblast growth factor 1 FGF1 0.003
5787 Angiopoietin-1 receptor TEK 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
6031 Cytochrome P450 3A43 CYP3A43 0.0029
1050 Bile salt sulfotransferase SULT2A1 0.0029
380 Cytochrome P450 17A1 CYP17A1 0.0029
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0029
683 Potassium transporter GK0582 0.0029
629 Alpha-2B adrenergic receptor ADRA2B 0.0029
823 Fibroblast growth factor receptor 2 FGFR2 0.0028
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3809 Estrogen-related receptor gamma ESRRG 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
267 Plasminogen activator inhibitor 1 SERPINE1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6042 Prostaglandin reductase 2 PTGR2 0.0025
6220 Aryl hydrocarbon receptor AHR 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
1792 Tissue-type plasminogen activator PLAT 0.0023
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0023
6043 Putative G-protein coupled receptor 44 GPR44 0.0023
713 Sodium-dependent dopamine transporter SLC6A3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0022
3937 Fatty-acid amide hydrolase FAAH 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
284 DNA-directed RNA polymerase beta chain rpoB 0.0022
5773 DNA-directed RNA polymerase beta chain rpoB 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
378 Alpha-2C adrenergic receptor ADRA2C 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
1313 Lactoylglutathione lyase GLO1 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
3947 Xanthine dehydrogenase/oxidase XDH 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
275 Arachidonate 5-lipoxygenase ALOX5 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
6432 Transporter snf 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
432 D(4) dopamine receptor DRD4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
427 Substance-P receptor TACR1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3957 Adenosine deaminase ADA 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2207 Rhodopsin RHO 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1757 Myeloperoxidase MPO 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
164 Histamine H4 receptor HRH4 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6020 Aldehyde oxidase AOX1 0.0002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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