DT-Web

DB00530 - Erlotinib


Identification
Name Erlotinib
Accession Number DB00530 (APRD00951)
Type small molecule
Description Erlotinib hydrochloride (trade name Tarceva, Genentech/OSIP, originally coded as OSI-774) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Similar to gefitinib, erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. Erlotinib has recently been shown to be a potent inhibitor of JAK2V617F activity. JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 393.4357
Groups approved
Monoisotopic Weight 393.168856239
Pharmacology
Indication For the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.
Mechanism of action The mechanism of clinical antitumor action of erlotinib is not fully characterized. Erlotinib inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor (EGFR). Specificity of inhibition with regard to other tyrosine kinase receptors has not been fully characterized. EGFR is expressed on the cell surface of normal cells and cancer cells.
Absorption Erlotinib is about 60% absorbed after oral administration and its bioavailability is substantially increased by food to almost 100%. Peak plasma levels occur 4 hours after dosing. The solubility of erlotinib is pH dependent. Solubility decreases pH increases. Smoking also decrease the exposure of erlotinib.
Protein binding 93% protein bound to albumin and alpha-1 acid glycoprotein (AAG)
Biotransformation Metabolism occurs in the liver. In vitro assays of cytochrome P450 metabolism showed that erlotinib is metabolized primarily by CYP3A4 and to a lesser extent by CYP1A2, and the extrahepatic isoform CYP1A1.
Route of elimination Following a 100 mg oral dose, 91% of the dose was recovered in which 83% was in feces (1% of the dose as unchanged parent compound) and 8% in urine (0.3% of the dose as unchanged parent compound).
Toxicity Symptoms of overdose include diarrhea, rash, and liver transaminase elevation. The most common adverse reactions (>50%) in NSCLC are rash, diarrhea, anorexia and fatigue. The most common adverse reactions (>50%) in pancreatic cancer are fatigue, rash, nausea and anorexia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Atazanavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Clarithromycin This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Erythromycin This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Indinavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Itraconazole Itraconazole may decrease the metabolism of erlotinib. Monitor for changes in the therapeutic and adverse effects of erlotinib if itraconazole is initiated, discontinued or dose changed.
Ketoconazole This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Nefazodone This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Nelfinavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Rifabutin Decreased levels/effect of erlotinib
Rifampin Decreased levels/effect of erlotinib
Rifapentine Decreased levels/effect of erlotinib
Ritonavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Saquinavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib
St. John's Wort Decreased levels/effect of erlotinib
Telithromycin Telithromycin may reduce clearance of Erlotinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erlotinib if Telithromycin is initiated, discontinued or dose changed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Troleandomycin This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of erlotinib by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of erlotinib if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take at least 1 hour before or 2 hours after any food.
  • Take with a glass of water.

Targets


Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action yes
Actions antagonist
References
  • Kim TE, Murren JR: Erlotinib OSI/Roche/Genentech. Curr Opin Investig Drugs. 2002 Sep;3(9):1385-95. - Pubmed
  • Laird AD, Cherrington JM: Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents. Expert Opin Investig Drugs. 2003 Jan;12(1):51-64. - Pubmed
  • Delbaldo C, Faivre S, Raymond E: [Epidermal growth factor inhibitors] Rev Med Interne. 2003 Jun;24(6):372-83. - Pubmed
  • Bulgaru AM, Mani S, Goel S, Perez-Soler R: Erlotinib (Tarceva): a promising drug targeting epidermal growth factor receptor tyrosine kinase. Expert Rev Anticancer Ther. 2003 Jun;3(3):269-79. - Pubmed
  • Akita RW, Sliwkowski MX: Preclinical studies with Erlotinib (Tarceva). Semin Oncol. 2003 Jun;30(3 Suppl 7):15-24. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5883
Nuclear receptor subfamily 1 group I member 2
Name Nuclear receptor subfamily 1 group I member 2
Gene Name NR1I2
Pharmacological action yes
Actions agonist
References
  • Harmsen S, Meijerman I, Beijnen JH, Schellens JH: Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemother Pharmacol. 2009 Jun;64(1):35-43. Epub 2008 Oct 7. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
DTHybrid score 0.3446

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Johnson JR, Cohen M, Sridhara R, Chen YF, Williams GM, Duan J, Gobburu J, Booth B, Benson K, Leighton J, Hsieh LS, Chidambaram N, Zimmerman P, Pazdur R: Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Clin Cancer Res. 2005 Sep 15;11(18):6414-21. - Pubmed
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
  • Hamilton M, Wolf JL, Rusk J, Beard SE, Clark GM, Witt K, Cagnoni PJ: Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2166-71. - Pubmed
DTHybrid score 0.9138
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
DTHybrid score 0.4711
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Lu JF, Eppler SM, Wolf J, Hamilton M, Rakhit A, Bruno R, Lum BL: Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer. Clin Pharmacol Ther. 2006 Aug;80(2):136-45. - Pubmed
  • Johnson JR, Cohen M, Sridhara R, Chen YF, Williams GM, Duan J, Gobburu J, Booth B, Benson K, Leighton J, Hsieh LS, Chidambaram N, Zimmerman P, Pazdur R: Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Clin Cancer Res. 2005 Sep 15;11(18):6414-21. - Pubmed
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
  • Hamilton M, Wolf JL, Rusk J, Beard SE, Clark GM, Witt K, Cagnoni PJ: Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2166-71. - Pubmed
DTHybrid score 0.5865
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Johnson JR, Cohen M, Sridhara R, Chen YF, Williams GM, Duan J, Gobburu J, Booth B, Benson K, Leighton J, Hsieh LS, Chidambaram N, Zimmerman P, Pazdur R: Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Clin Cancer Res. 2005 Sep 15;11(18):6414-21. - Pubmed
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
DTHybrid score 0.3794
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
DTHybrid score 0.606
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Hamilton M, Wolf JL, Rusk J, Beard SE, Clark GM, Witt K, Cagnoni PJ: Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2166-71. - Pubmed
DTHybrid score 0.4687
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions substrate
References
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
DTHybrid score 0.2255
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • Liu Y, Ramirez J, House L, Ratain MJ: The UGT1A1*28 polymorphism correlates with erlotinib's effect on SN-38 glucuronidation. Eur J Cancer. 2010 Jul;46(11):2097-103. doi: 10.1016/j.ejca.2010.04.022. Epub 2010 May 23. - Pubmed
DTHybrid score 0.2366

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
DTHybrid score 0.3934
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Marchetti S, de Vries NA, Buckle T, Bolijn MJ, van Eijndhoven MA, Beijnen JH, Mazzanti R, van Tellingen O, Schellens JH: Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice. Mol Cancer Ther. 2008 Aug;7(8):2280-7. - Pubmed
DTHybrid score 0.6771

Carriers


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.3934
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6771

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.454
6016 Cytochrome P450 2C19 CYP2C19 0.393
6107 Cytochrome P450 3A7 CYP3A7 0.2822
6030 Cytochrome P450 2B6 CYP2B6 0.2383
6013 Cytochrome P450 2E1 CYP2E1 0.2023
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1624
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1613
862 Multidrug resistance-associated protein 1 ABCC1 0.1412
5718 Cytochrome P450 2A6 CYP2A6 0.1412
20 Prostaglandin G/H synthase 1 PTGS1 0.1331
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1147
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.099
1729 Solute carrier family 22 member 6 SLC22A6 0.0921
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0908
776 Bile salt export pump ABCB11 0.0898
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.089
6145 Solute carrier family 22 member 1 SLC22A1 0.0865
6106 Cytochrome P450 2C18 CYP2C18 0.0843
290 Prostaglandin G/H synthase 2 PTGS2 0.0832
492 Histamine H1 receptor HRH1 0.083
220 Sodium channel protein type 5 subunit alpha SCN5A 0.082
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0807
556 Alpha-1A adrenergic receptor ADRA1A 0.0787
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0767
824 Sodium-dependent serotonin transporter SLC6A4 0.0763
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0746
6144 Solute carrier family 22 member 2 SLC22A2 0.0716
3811 Cytochrome P450 19A1 CYP19A1 0.0691
502 5-hydroxytryptamine 2A receptor HTR2A 0.0675
136 Estrogen receptor ESR1 0.0667
831 D(2) dopamine receptor DRD2 0.0659
320 5-hydroxytryptamine 1A receptor HTR1A 0.0611
6142 Solute carrier family 22 member 8 SLC22A8 0.0611
766 Beta-2 adrenergic receptor ADRB2 0.0608
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0587
284 DNA-directed RNA polymerase beta chain rpoB 0.0574
5773 DNA-directed RNA polymerase beta chain rpoB 0.0574
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0571
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0565
2164 Multidrug resistance-associated protein 4 ABCC4 0.055
193 Beta-1 adrenergic receptor ADRB1 0.0544
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.054
847 Mu-type opioid receptor OPRM1 0.053
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0524
318 Alpha-2A adrenergic receptor ADRA2A 0.0522
6148 Multidrug resistance-associated protein 7 ABCC10 0.0509
871 Glucocorticoid receptor NR3C1 0.0509
632 Alpha-1B adrenergic receptor ADRA1B 0.0506
817 DNA topoisomerase 2-alpha TOP2A 0.0504
6143 Solute carrier family 22 member 7 SLC22A7 0.0504
118 Organic cation/carnitine transporter 2 SLC22A5 0.0503
6147 Solute carrier family 22 member 3 SLC22A3 0.0494
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0492
468 Cytochrome P450 4A11 CYP4A11 0.0482
617 Muscarinic acetylcholine receptor M2 CHRM2 0.046
23 D(1A) dopamine receptor DRD1 0.0453
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0452
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0447
696 Kappa-type opioid receptor OPRK1 0.0431
504 Mast/stem cell growth factor receptor KIT 0.0426
467 Delta-type opioid receptor OPRD1 0.0422
6141 Sodium/bile acid cotransporter SLC10A1 0.0415
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.041
1024 Solute carrier family 22 member 11 SLC22A11 0.0405
590 5-hydroxytryptamine 2C receptor HTR2C 0.0402
789 Alpha-1D adrenergic receptor ADRA1D 0.0399
713 Sodium-dependent dopamine transporter SLC6A3 0.0393
3947 Xanthine dehydrogenase/oxidase XDH 0.039
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0379
465 Calmodulin CALM1 0.0373
6031 Cytochrome P450 3A43 CYP3A43 0.0371
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.037
146 Androgen receptor AR 0.0363
3941 Amine oxidase [flavin-containing] A MAOA 0.0362
275 Arachidonate 5-lipoxygenase ALOX5 0.0356
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0353
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0351
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0351
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0343
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.034
5787 Angiopoietin-1 receptor TEK 0.0337
731 HIV-1 protease HIV-1 protease 0.0337
885 5-hydroxytryptamine 1B receptor HTR1B 0.0336
6137 Multidrug resistance-associated protein 6 ABCC6 0.0331
36 Insulin receptor INSR 0.0325
341 5-hydroxytryptamine 3 receptor HTR3A 0.0319
228 Beta platelet-derived growth factor receptor PDGFRB 0.0319
3923 Cholinesterase BCHE 0.0314
26 Vascular endothelial growth factor receptor 3 FLT4 0.0307
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0307
5300 Antigen peptide transporter 1 TAP1 0.0304
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0301
756 Sex hormone-binding globulin SHBG 0.0301
833 Organic cation/carnitine transporter 1 SLC22A4 0.0298
638 D(3) dopamine receptor DRD3 0.0297
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0295
32 Vascular endothelial growth factor receptor 1 FLT1 0.0294
4604 Liver carboxylesterase 1 CES1 0.0289
183 Vascular endothelial growth factor A VEGFA 0.0287
6220 Aryl hydrocarbon receptor AHR 0.0285
29 Tubulin beta-1 chain TUBB1 0.0284
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0282
6182 Cytochrome P450 2J2 CYP2J2 0.028
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.028
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0279
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0278
629 Alpha-2B adrenergic receptor ADRA2B 0.0275
891 Dihydropteroate synthase folP 0.0275
5359 Dihydropteroate synthase folP 0.0275
7175 Dihydropteroate synthase sulI 0.0275
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0275
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0275
407 Vascular endothelial growth factor receptor 2 KDR 0.0274
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0273
725 5-hydroxytryptamine 1D receptor HTR1D 0.0272
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0266
6026 Alcohol dehydrogenase 6 ADH6 0.0266
380 Cytochrome P450 17A1 CYP17A1 0.0265
869 Estrogen receptor beta ESR2 0.0265
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0264
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0262
88 Retinoic acid receptor RXR-beta RXRB 0.0261
273 Apoptosis regulator Bcl-2 BCL2 0.0257
378 Alpha-2C adrenergic receptor ADRA2C 0.0253
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0248
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0242
6283 Oxysterols receptor LXR-alpha NR1H3 0.0242
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0241
1353 DNA topoisomerase 1 TOP1 0.0241
3552 DNA topoisomerase 1 topA 0.0241
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0241
3939 Amine oxidase [flavin-containing] B MAOB 0.0239
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0239
373 Transthyretin TTR 0.0233
1757 Myeloperoxidase MPO 0.0231
1517 Beta-3 adrenergic receptor ADRB3 0.0231
260 Cytochrome P450 51 ERG11 0.0229
761 Cytochrome P450 51 ERG11 0.0229
3163 Cytochrome P450 51 cyp51 0.0229
6136 Multidrug resistance-associated protein 5 ABCC5 0.0227
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0226
1852 Microtubule-associated protein 2 MAP2 0.0224
777 Tumor necrosis factor TNF 0.0223
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0222
477 DNA topoisomerase 4 subunit A parC 0.0222
886 DNA topoisomerase 4 subunit A parC 0.0222
6226 DNA topoisomerase 4 subunit A parC 0.0222
2782 Complement C1s subcomponent C1S 0.0221
614 Progesterone receptor PGR 0.022
4120 NADPH--cytochrome P450 reductase POR 0.022
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0219
404 DNA gyrase subunit A gyrA 0.0218
6224 DNA gyrase subunit A gyrA 0.0218
6085 Fatty acid-binding protein, intestinal FABP2 0.0214
5923 Microtubule-associated protein tau MAPT 0.0213
5924 Microtubule-associated protein 4 MAP4 0.0213
70 Type-1 angiotensin II receptor AGTR1 0.0212
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0212
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0211
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0208
6228 Nuclear receptor coactivator 1 NCOA1 0.0206
6014 Cytochrome P450 2A13 CYP2A13 0.0205
904 Glutathione S-transferase P GSTP1 0.0203
3817 Complement C1q subcomponent subunit C C1QC 0.0202
3816 Complement C1q subcomponent subunit B C1QB 0.0202
3815 Complement C1q subcomponent subunit A C1QA 0.0202
6241 Nuclear receptor coactivator 2 NCOA2 0.0201
3950 Cell division protein kinase 9 CDK9 0.02
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.02
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.02
3968 Cell division protein kinase 8 CDK8 0.02
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.02
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.02
3814 Complement C1r subcomponent C1R 0.02
432 D(4) dopamine receptor DRD4 0.0198
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0198
1178 Adenosine A2a receptor ADORA2A 0.0198
6102 Arylamine N-acetyltransferase 2 NAT2 0.0198
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0196
16 Adenosine A1 receptor ADORA1 0.0195
3932 Glutathione S-transferase A2 GSTA2 0.0194
4228 Keratin, type II cytoskeletal 7 KRT7 0.0194
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0191
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0191
4203 Histamine N-methyltransferase HNMT 0.0189
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0187
117 Sterol O-acyltransferase 1 SOAT1 0.018
436 5-hydroxytryptamine 2B receptor HTR2B 0.018
122 P2Y purinoceptor 12 P2RY12 0.0179
3810 Catechol O-methyltransferase COMT 0.0179
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0179
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0179
5880 Thrombopoietin receptor MPL 0.0178
33 Cystine/glutamate transporter SLC7A11 0.0178
1192 Sulfotransferase 1A1 SULT1A1 0.0177
3959 Cell division protein kinase 4 CDK4 0.0176
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0173
3482 Cell division protein kinase 7 CDK7 0.0172
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0172
1050 Bile salt sulfotransferase SULT2A1 0.0171
737 Mineralocorticoid receptor NR3C2 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
738 Monocarboxylate transporter 1 SLC16A1 0.0168
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0167
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0166
811 Translocator protein TSPO 0.0165
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0165
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0164
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0164
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0164
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0163
3955 Cell division protein kinase 6 CDK6 0.0162
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0161
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.016
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0155
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0155
952 Dipeptidyl peptidase 4 DPP4 0.0154
1010 Cytochrome P450 51A1 CYP51A1 0.0154
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0153
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0153
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0152
319 Opioid receptor, sigma 1 OPRS1 0.0151
232 Corticosteroid-binding globulin SERPINA6 0.015
716 5-hydroxytryptamine 7 receptor HTR7 0.0149
2449 Tubulin alpha-3 chain TUBA1A 0.0148
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0148
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0148
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0147
4122 Histone deacetylase 2 HDAC2 0.0146
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0146
1656 CYP2B protein CYP2B 0.0145
908 Glutathione S-transferase theta-1 GSTT1 0.0144
2499 Tubulin beta-2C chain TUBB2C 0.0144
124 Histamine H2 receptor HRH2 0.0143
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
474 Acetylcholinesterase ACHE 0.0141
1618 High affinity nerve growth factor receptor NTRK1 0.0141
4192 DNA topoisomerase 2-beta TOP2B 0.014
705 Glutamate receptor 1 GRIA1 0.014
1742 D-HSCDK2 CDK2deltaT 0.014
1771 Cell division control protein 2 homolog CDK1 0.014
3321 Cell division control protein 2 homolog CRK2 0.014
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0137
1629 Transcription factor AP-1 JUN 0.0137
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0136
3856 Fibroblast growth factor receptor 3 FGFR3 0.0136
1058 Cell division protein kinase 5 CDK5 0.0135
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0135
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
161 Tubulin beta chain TUBB 0.0134
312 Tubulin beta chain TUB2 0.0134
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0133
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0132
165 FL cytokine receptor FLT3 0.0132
818 50S ribosomal protein L10 rplJ 0.0131
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0131
6146 High affinity copper uptake protein 1 SLC31A1 0.013
768 FK506-binding protein 1A FKBP1A 0.013
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.013
936 Ephrin type-A receptor 2 EPHA2 0.0127
163 D(1B) dopamine receptor DRD5 0.0126
2112 Toll-like receptor 9 TLR9 0.0126
1714 Mitogen-activated protein kinase 3 MAPK3 0.0126
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0125
814 Ryanodine receptor 1 RYR1 0.0124
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0124
823 Fibroblast growth factor receptor 2 FGFR2 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
1256 5-hydroxytryptamine 6 receptor HTR6 0.0121
2539 Tubulin alpha-1 chain TUBA4A 0.0121
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0119
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0119
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0117
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0117
48 Pyridoxal kinase PDXK 0.0116
469 Annexin A1 ANXA1 0.0116
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0115
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0115
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0114
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0114
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0114
2211 Fatty acid-binding protein, heart FABP3 0.0114
4773 Deoxycytidine kinase DCK 0.0114
6043 Putative G-protein coupled receptor 44 GPR44 0.0113
2183 Fatty acid-binding protein, adipocyte FABP4 0.0113
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0111
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0111
283 SEC14-like protein 2 SEC14L2 0.0111
571 Melatonin receptor type 1A MTNR1A 0.0111
362 Melatonin receptor type 1B MTNR1B 0.011
94 5-hydroxytryptamine 4 receptor HTR4 0.0109
6020 Aldehyde oxidase AOX1 0.0107
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
992 Protein tyrosine kinase 2 beta PTK2B 0.0104
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0104
482 Glycine receptor subunit alpha-1 GLRA1 0.0103
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0103
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0103
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0102
239 Coagulation factor X F10 0.0102
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0102
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0102
1063 Signal transducer and activator of transcription 5B STAT5B 0.0101
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0101
528 5-hydroxytryptamine 1E receptor HTR1E 0.01
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0099
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0096
365 Dihydrofolate reductase DHFR 0.0096
2381 Dihydrofolate reductase DFR1 0.0096
2833 Dihydrofolate reductase Not Available 0.0096
2931 Dihydrofolate reductase folA 0.0096
3544 Dihydrofolate reductase folA 0.0096
3682 Dihydrofolate reductase folA 0.0096
6642 Dihydrofolate reductase folA 0.0096
6756 Dihydrofolate reductase dfrA 0.0096
68 Cannabinoid receptor 1 CNR1 0.0096
5934 Cytochrome P450 26A1 CYP26A1 0.0096
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0096
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0095
84 Nuclear receptor 0B1 NR0B1 0.0095
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0094
566 Serotransferrin TF 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
1569 G1/S-specific cyclin-D1 CCND1 0.0094
6163 Copper-transporting ATPase 2 ATP7B 0.0094
6165 Copper-transporting ATPase 1 ATP7A 0.0094
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0093
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0092
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0092
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0092
244 Angiotensin-converting enzyme ACE 0.0092
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0092
4311 tRNA TRDMT1 0.0092
4325 tRNA trmD 0.0092
4328 tRNA trmD 0.0092
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0091
775 Acetyl-CoA carboxylase 2 ACACB 0.0091
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0091
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0091
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0091
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0091
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0091
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0091
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.009
1152 Glycogen phosphorylase, muscle form PYGM 0.009
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.009
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.009
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.009
6432 Transporter snf 0.009
997 Protein kinase C beta type PRKCB 0.0089
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0088
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0088
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0088
6044 Serum paraoxonase/lactonase 3 PON3 0.0087
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0087
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0087
86 SEC14-like protein 4 SEC14L4 0.0087
375 SEC14-like protein 3 SEC14L3 0.0087
4076 Diacylglycerol kinase alpha DGKA 0.0087
2240 Cell division protein kinase 2 CDK2 0.0087
537 ATP synthase delta chain, mitochondrial ATP5D 0.0087
4237 50S ribosomal protein L22 rplV 0.0087
511 5-hydroxytryptamine 1F receptor HTR1F 0.0087
131 Synaptic vesicular amine transporter SLC18A2 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0085
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0085
1760 Aminopeptidase N ANPEP 0.0085
6843 Aminopeptidase N pepN 0.0085
484 Tyrosine-protein kinase ABL2 ABL2 0.0084
3937 Fatty-acid amide hydrolase FAAH 0.0084
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
896 Glutathione S-transferase Mu 1 GSTM1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
2236 Casein kinase II subunit alpha CSNK2A1 0.0082
708 Alpha-tocopherol transfer protein TTPA 0.0082
1970 Protein kinase C alpha type PRKCA 0.0081
3809 Estrogen-related receptor gamma ESRRG 0.0081
24 Thymidylate synthase TMP1 0.008
359 Thymidylate synthase TYMS 0.008
2626 Thymidylate synthase thyA 0.008
2729 Thymidylate synthase thyA 0.008
5352 Thymidylate synthase THYA 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.008
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0079
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0079
173 Toll-like receptor 7 TLR7 0.0079
427 Substance-P receptor TACR1 0.0078
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0077
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0077
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
162 Retinoic acid receptor gamma-1 RARG 0.0074
3957 Adenosine deaminase ADA 0.0074
7 Nitric oxide synthase, inducible NOS2 0.0074
6766 O-GlcNAcase BT_4395 BT_4395 0.0074
4238 50S ribosomal protein L4 rplD 0.0074
5578 50S ribosomal protein L4 rplD 0.0074
6173 50S ribosomal protein L4 rplD 0.0074
6219 50S ribosomal protein L4 rplD 0.0074
1630 Integrin beta-2 ITGB2 0.0074
3917 Methylenetetrahydrofolate reductase MTHFR 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
899 Glutathione S-transferase Mu 3 GSTM3 0.0072
905 Glutathione transferase omega-1 GSTO1 0.0072
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
268 Adenosine A2b receptor ADORA2B 0.0071
1650 Heme carrier protein 1 SLC46A1 0.0071
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0071
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0071
3830 Calreticulin CALR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1864 RET proto-oncogene RET 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.007
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
106 Cannabinoid receptor 2 CNR2 0.007
594 Thyroxine-binding globulin SERPINA7 0.007
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0069
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0069
780 Retinoic acid receptor RXR-gamma RXRG 0.0069
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0069
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0069
295 Carbonic anhydrase 1 CA1 0.0068
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0068
3086 Plasmepsin-2 Not Available 0.0068
4103 Proteasome subunit beta type 2 PSMB2 0.0067
4102 Proteasome subunit beta type 5 PSMB5 0.0067
4101 Proteasome subunit beta type 1 PSMB1 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
6034 Hydroxyindole O-methyltransferase ASMT 0.0066
6035 Nuclear receptor ROR-beta RORB 0.0066
6036 Eosinophil peroxidase EPX 0.0066
810 Heme oxygenase 1 HMOX1 0.0066
3391 Heme oxygenase 1 pbsA1 0.0066
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0066
208 DNA-directed RNA polymerase beta' chain rpoC 0.0065
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0065
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0065
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0065
758 Thyroid hormone receptor alpha THRA 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
921 Glutamate receptor 2 GRIA2 0.0062
976 Platelet glycoprotein IX GP9 0.0062
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0062
856 Vitamin D3 receptor VDR 0.0061
760 Fibroblast growth factor 1 FGF1 0.0061
1275 Estrogen sulfotransferase SULT1E1 0.0061
2981 Phospholipase A2, membrane associated PLA2G2A 0.0061
558 Solute carrier family 12 member 1 SLC12A1 0.0061
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0061
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
820 Glycine receptor subunit alpha-2 GLRA2 0.0059
6149 Solute carrier family 22 member 10 SLC22A10 0.0059
1992 Vitamin D-binding protein GC 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
6824 Tyrosine-protein kinase Lyn LYN 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
229 Retinoic acid receptor beta RARB 0.0058
3426 Glutamine synthetase glnA 0.0058
3987 Glutamine synthetase GLUL 0.0058
346 Thyroid hormone receptor beta-1 THRB 0.0058
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0057
765 Indoleamine 2,3-dioxygenase IDO1 0.0057
5798 Mitogen-activated protein kinase 11 MAPK11 0.0057
730 Retinoic acid receptor alpha RARA 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0057
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
267 Plasminogen activator inhibitor 1 SERPINE1 0.0056
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
572 Integrin alpha-L ITGAL 0.0056
459 Retinoic acid receptor RXR-alpha RXRA 0.0055
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0055
6506 Stathmin-4 STMN4 0.0055
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0055
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0054
54 Prothrombin F2 0.0054
751 Potassium channel subfamily K member 6 KCNK6 0.0054
2853 14 kDa fatty acid-binding protein Not Available 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2216 Fibroblast growth factor receptor 4 FGFR4 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
581 Cytochrome P450 2R1 CYP2R1 0.0052
712 Tubulin alpha chain TUB1 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
6221 Steroid hormone receptor ERR1 ESRRA 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
2021 Thrombomodulin THBD 0.0051
1525 Heparin-binding growth factor 2 FGF2 0.0051
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
634 Squalene monooxygenase SQLE 0.0049
7196 Squalene monooxygenase ERG1 0.0049
1541 Metalloproteinase mmp20 0.0049
172 Potassium channel subfamily K member 1 KCNK1 0.0049
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0049
164 Histamine H4 receptor HRH4 0.0049
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0049
4217 Telomerase reverse transcriptase TERT 0.0048
4210 Toll-like receptor 4 TLR4 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
1648 Elastin ELN 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
6174 50S ribosomal protein L32 rpmF 0.0047
6677 Myelin P2 protein PMP2 0.0047
4692 A/G-specific adenine glycosylase mutY 0.0047
174 Sigma 1-type opioid receptor SIGMAR1 0.0047
6103 Arylamine N-acetyltransferase 1 NAT1 0.0047
592 Carbonic anhydrase 4 CA4 0.0047
683 Potassium transporter GK0582 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
518 Peroxidase/catalase T katG 0.0046
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0046
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0046
199 Monocarboxylate transporter 8 SLC16A2 0.0046
6167 Organic solute transporter subunit beta OSTB 0.0045
6166 Organic solute transporter subunit alpha OSTA 0.0045
1291 cAMP response element-binding protein CREB1 0.0045
4226 Uridine phosphorylase 2 UPP2 0.0045
1483 Membrane copper amine oxidase AOC3 0.0045
357 Carbonic anhydrase 2 CA2 0.0045
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
707 72 kDa type IV collagenase MMP2 0.0044
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0043
4225 Uridine phosphorylase 1 UPP1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0042
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0042
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0042
569 Retinal dehydrogenase 2 ALDH1A2 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
6168 Solute carrier family 22 member 16 SLC22A16 0.0042
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0041
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0041
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0041
1374 Natriuretic peptides B NPPB 0.0041
1827 Gap junction alpha-1 protein GJA1 0.0041
1908 Vascular cell adhesion protein 1 VCAM1 0.0041
293 Gamma-glutamyl hydrolase GGH 0.0041
153 Dopamine beta-hydroxylase DBH 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.004
4161 Furin FURIN 0.004
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.004
611 Retinal dehydrogenase 1 ALDH1A1 0.0039
413 Amidophosphoribosyltransferase PPAT 0.0039
2515 Amidophosphoribosyltransferase purF 0.0039
3714 Amidophosphoribosyltransferase purF 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
2320 Thymidine kinase, cytosolic TK1 0.0038
233 Potassium channel subfamily K member 2 KCNK2 0.0038
65 Matrix metalloproteinase-9 Not Available 0.0037
1196 Complement decay-accelerating factor CD55 0.0036
3616 Fatty acid-binding protein, epidermal FABP5 0.0036
5431 Lipid binding protein Not Available 0.0036
5433 UPF0230 protein TM_1468 TM_1468 0.0036
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0035
1792 Tissue-type plasminogen activator PLAT 0.0035
1360 Sphingomyelin phosphodiesterase SMPD1 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
822 Aldose reductase AKR1B1 0.0035
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0035
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
719 Retinoic acid receptor responder protein 1 RARRES1 0.0035
770 Retinoic acid-induced protein 3 GPRC5A 0.0035
489 Monocarboxylate transporter 2 SLC16A7 0.0035
939 50S ribosomal protein L3 rplC 0.0035
291 Nitric-oxide synthase, endothelial NOS3 0.0035
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
2207 Rhodopsin RHO 0.0033
6033 High affinity interleukin-8 receptor A CXCR1 0.0033
6459 Glycodelin PAEP 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
5626 Nucleoside diphosphate kinase B NME2 0.0033
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0033
6042 Prostaglandin reductase 2 PTGR2 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0032
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0032
331 Retinol-binding protein I, cellular RBP1 0.0032
3639 Thymidine phosphorylase deoA 0.0032
3936 Thymidine phosphorylase TYMP 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1867 Major prion protein PRNP 0.0032
6048 Troponin C, skeletal muscle TNNC2 0.0032
2808 Chloramphenicol acetyltransferase 3 cat3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6126 Carbonic anhydrase 7 CA7 0.003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
702 UMP-CMP kinase CMPK1 0.003
6151 Monocarboxylate transporter 10 SLC16A10 0.003
76 Nitric-oxide synthase, brain NOS1 0.003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0029
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
2417 Chloramphenicol acetyltransferase cat 0.0029
3278 Chloramphenicol acetyltransferase cat 0.0029
3601 Dihydropteroate synthase 1 folP1 0.0029
3807 Dihydropteroate synthase 1 folP1 0.0029
3808 Dihydropteroate synthase 2 folP2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2810 Dr hemagglutinin structural subunit draA 0.0029
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
5294 Nucleoside diphosphate kinase A NME1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
563 Thyroid peroxidase TPO 0.0026
444 Alcohol dehydrogenase 1B ADH1B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
49 Endothelin B receptor EDNRB 0.0026
6859 Protein S100-A4 S100A4 0.0025
251 Alcohol dehydrogenase 1A ADH1A 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
1313 Lactoylglutathione lyase GLO1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6231 Pepsin A PGA3 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
6218 Pannexin-1 PANX1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
517 Alcohol dehydrogenase 1C ADH1C 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
5818 Folate receptor alpha FOLR1 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1039 Histone deacetylase 9 HDAC9 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
6122 Carbonic anhydrase 3 CA3 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3587 Gastrotropin FABP6 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0017
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0017
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0017
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0017
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0017
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0016
798 Osteocalcin BGLAP 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
1243 Cathepsin D CTSD 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0014
6072 Potassium channel subfamily K member 3 KCNK3 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1341 Histamine H3 receptor HRH3 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2298 Cytochrome P450-cam camC 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3221 Cytochrome c4 cc4 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4916 Cyanoglobin glbN 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
5000 HemO hemO 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4984 Neuroglobin NGB 0.0006
4961 Hemophore HasA hasA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4909 CooA protein cooA 0.0006
4910 Cytoglobin CYGB 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4972 P450cin cinA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
4920 Peroxidase/catalase katG 0.0005
5961 Insulin INS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4948 Cytochrome c-553 Not Available 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4923 Cytochrome c3 DvMF_2499 0.0005
4945 Cytochrome c3 Not Available 0.0005
4949 Cytochrome c3 DVU_3171 0.0005
4968 Cytochrome c3 cytc3 0.0005
4997 Cytochrome c3 SO_2727 0.0005
5219 Cytochrome c3 cyd 0.0005
4902 Nine-heme cytochrome c Ddes_2038 0.0005
3189 High-molecular-weight cytochrome c hmcA 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
3127 Nitrite reductase nirS 0.0004
3284 Nitrite reductase nirS 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
358 Cystathionine beta-synthase CBS 0.0003
1507 Cytochrome c CYCS 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
693 Hemoglobin subunit beta HBB 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
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