DT-Web

DB01201 - Rifapentine


Identification
Name Rifapentine
Accession Number DB01201 (APRD01217)
Type small molecule
Description Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 877.0307
Groups approved
Monoisotopic Weight 876.452073532
Pharmacology
Indication For the treatment of pulmonary tuberculosis.
Mechanism of action Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
Absorption Rapidly and well absorbed from the gastrointestinal tract.
Protein binding 97.7% (bound to plasma proteins)
Biotransformation Hepatic
Route of elimination Following a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%).
Toxicity Not Available
Affected organisms
  • Mycobacterium
Interactions
Drug Interactions
Drug Mechanism of interaction
Abiraterone Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Bromazepam Rifapentine may decrease the serum concentration of bromazepam by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if rifapentine is initiated, discontinued or dose changed.
Cabazitaxel Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Erlotinib Decreased levels/effect of erlotinib
Estradiol valerate/Dienogest Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
Methadone The rifamycin decreases the effect of methadone
Norethindrone This product may cause a slight decrease of contraceptive effect
Rilpivirine Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Roflumilast Affects CYP3A4 metabolism, decreases level or effect of roflumilast.
Telithromycin Rifapentine may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus Rifapentine may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Terbinafine Rifapentine may increase the metabolism and clearance of Terbinafine. To avoid Terbinafine treatment failure, co-administration should be avoided.
Tipranavir Concomitant therapy may cause decreased Tipranavir and increased Rifapentine plasma concentrations.
Tramadol Rifapentine may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inducer, Rifapentine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Rifapentine is initiated, discontinued or dose changed.
Tretinoin The strong CYP2C8 inducer, Rifapentine, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rifapentine is initiated, discontinued or dose changed.
Vandetanib Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vemurafenib Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Verapamil Rifapentine, a CYP3A4 inducer, may decrease the serum concentration of Verapamil by increasing its metabolism (particularly in the intestinal mucosa) and decreasing its absorption. Monitor for changes in the therapeutic/adverse effects of Verapamil if Rifapentine is initiated, discontinued or dose changed.
Voriconazole Rifapentine may decrease the serum concentration of voriconazole likely by increasing its metabolism via CYP3A enzymes. Voriconazole may increase the serum concentration of rifapentin likely by inhibiting its metabolism via CYP3A. Concomitant therapy is contraindicated.
Zidovudine Rifapentin may decrease the serum concentration of zidovudine by increasing its metabolism. Monitor for changes in the serum concentration and therapeutic and adverse effects of zidovudine if rifapentin is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


DNA-directed RNA polymerase beta' chain
Name DNA-directed RNA polymerase beta' chain
Gene Name rpoC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Williams DL, Spring L, Collins L, Miller LP, Heifets LB, Gangadharam PR, Gillis TP: Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7. - Pubmed
  • Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. Epub 2010 Feb 24. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4933
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.717
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3997
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5126
Cytochrome P450 3A43
Name Cytochrome P450 3A43
Gene Name CYP3A43
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2508
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4922
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4136

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.3
5774 DNA-directed RNA polymerase beta' chain rpoC 0.2839
1588 Multidrug resistance protein 1 ABCB1 0.2547
4200 Cytochrome P450 1A2 CYP1A2 0.2287
6030 Cytochrome P450 2B6 CYP2B6 0.1613
6013 Cytochrome P450 2E1 CYP2E1 0.1444
6024 Cytochrome P450 1A1 CYP1A1 0.0996
5718 Cytochrome P450 2A6 CYP2A6 0.0971
587 Serum albumin ALB 0.0837
20 Prostaglandin G/H synthase 1 PTGS1 0.0822
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0803
6106 Cytochrome P450 2C18 CYP2C18 0.0658
492 Histamine H1 receptor HRH1 0.0654
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0646
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0629
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0588
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0561
824 Sodium-dependent serotonin transporter SLC6A4 0.0544
862 Multidrug resistance-associated protein 1 ABCC1 0.054
847 Mu-type opioid receptor OPRM1 0.0489
1729 Solute carrier family 22 member 6 SLC22A6 0.0465
502 5-hydroxytryptamine 2A receptor HTR2A 0.0452
831 D(2) dopamine receptor DRD2 0.0449
1898 Cytochrome P450 1B1 CYP1B1 0.0448
6145 Solute carrier family 22 member 1 SLC22A1 0.0445
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0438
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0433
3811 Cytochrome P450 19A1 CYP19A1 0.0432
776 Bile salt export pump ABCB11 0.041
290 Prostaglandin G/H synthase 2 PTGS2 0.0405
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0404
6143 Solute carrier family 22 member 7 SLC22A7 0.0401
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0386
556 Alpha-1A adrenergic receptor ADRA1A 0.0386
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0376
871 Glucocorticoid receptor NR3C1 0.037
467 Delta-type opioid receptor OPRD1 0.0365
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0364
320 5-hydroxytryptamine 1A receptor HTR1A 0.036
103 Muscarinic acetylcholine receptor M1 CHRM1 0.035
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0347
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0343
696 Kappa-type opioid receptor OPRK1 0.0336
766 Beta-2 adrenergic receptor ADRB2 0.0328
6144 Solute carrier family 22 member 2 SLC22A2 0.0326
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0306
713 Sodium-dependent dopamine transporter SLC6A3 0.0304
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0303
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0302
731 HIV-1 protease HIV-1 protease 0.0295
318 Alpha-2A adrenergic receptor ADRA2A 0.0293
590 5-hydroxytryptamine 2C receptor HTR2C 0.0287
341 5-hydroxytryptamine 3 receptor HTR3A 0.0285
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0278
3941 Amine oxidase [flavin-containing] A MAOA 0.0275
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0266
118 Organic cation/carnitine transporter 2 SLC22A5 0.0266
2164 Multidrug resistance-associated protein 4 ABCC4 0.0264
136 Estrogen receptor ESR1 0.0264
468 Cytochrome P450 4A11 CYP4A11 0.0261
6142 Solute carrier family 22 member 8 SLC22A8 0.026
23 D(1A) dopamine receptor DRD1 0.026
632 Alpha-1B adrenergic receptor ADRA1B 0.0258
193 Beta-1 adrenergic receptor ADRB1 0.0248
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0247
638 D(3) dopamine receptor DRD3 0.0246
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0241
6182 Cytochrome P450 2J2 CYP2J2 0.0239
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0237
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0236
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0236
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0235
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0233
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0229
6147 Solute carrier family 22 member 3 SLC22A3 0.0228
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0222
260 Cytochrome P450 51 ERG11 0.0221
761 Cytochrome P450 51 ERG11 0.0221
3163 Cytochrome P450 51 cyp51 0.0221
6174 50S ribosomal protein L32 rpmF 0.0207
614 Progesterone receptor PGR 0.0206
833 Organic cation/carnitine transporter 1 SLC22A4 0.0206
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0206
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0203
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0201
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0201
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0197
3939 Amine oxidase [flavin-containing] B MAOB 0.0195
465 Calmodulin CALM1 0.0191
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0184
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0183
380 Cytochrome P450 17A1 CYP17A1 0.0182
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0181
737 Mineralocorticoid receptor NR3C2 0.018
146 Androgen receptor AR 0.018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0179
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0178
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0176
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0175
817 DNA topoisomerase 2-alpha TOP2A 0.0175
6148 Multidrug resistance-associated protein 7 ABCC10 0.0174
756 Sex hormone-binding globulin SHBG 0.0172
811 Translocator protein TSPO 0.0171
891 Dihydropteroate synthase folP 0.0171
5359 Dihydropteroate synthase folP 0.0171
7175 Dihydropteroate synthase sulI 0.0171
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0166
629 Alpha-2B adrenergic receptor ADRA2B 0.0165
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0162
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0162
378 Alpha-2C adrenergic receptor ADRA2C 0.0161
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
432 D(4) dopamine receptor DRD4 0.0158
4773 Deoxycytidine kinase DCK 0.0157
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0157
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0156
1483 Membrane copper amine oxidase AOC3 0.0156
232 Corticosteroid-binding globulin SERPINA6 0.0156
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0154
122 P2Y purinoceptor 12 P2RY12 0.0154
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0154
6136 Multidrug resistance-associated protein 5 ABCC5 0.0153
504 Mast/stem cell growth factor receptor KIT 0.0151
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0151
6141 Sodium/bile acid cotransporter SLC10A1 0.015
3913 Glutamic acid decarboxylase GAD65 0.0149
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0147
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0144
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0144
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0144
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0143
844 Epidermal growth factor receptor EGFR 0.0142
70 Type-1 angiotensin II receptor AGTR1 0.0141
725 5-hydroxytryptamine 1D receptor HTR1D 0.0141
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0141
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0141
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0141
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0141
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0139
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0139
789 Alpha-1D adrenergic receptor ADRA1D 0.0139
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0138
1024 Solute carrier family 22 member 11 SLC22A11 0.0136
94 5-hydroxytryptamine 4 receptor HTR4 0.0134
29 Tubulin beta-1 chain TUBB1 0.0127
469 Annexin A1 ANXA1 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0126
3904 Alanine aminotransferase 2 GPT2 0.0125
735 Alanine aminotransferase 1 GPT 0.0125
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0122
407 Vascular endothelial growth factor receptor 2 KDR 0.0121
84 Nuclear receptor 0B1 NR0B1 0.0121
6014 Cytochrome P450 2A13 CYP2A13 0.012
4604 Liver carboxylesterase 1 CES1 0.0119
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0118
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0118
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0116
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
6102 Arylamine N-acetyltransferase 2 NAT2 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0115
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0114
952 Dipeptidyl peptidase 4 DPP4 0.0111
3923 Cholinesterase BCHE 0.0111
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
716 5-hydroxytryptamine 7 receptor HTR7 0.011
228 Beta platelet-derived growth factor receptor PDGFRB 0.011
1010 Cytochrome P450 51A1 CYP51A1 0.0107
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0107
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0107
6220 Aryl hydrocarbon receptor AHR 0.0107
26 Vascular endothelial growth factor receptor 3 FLT4 0.0106
436 5-hydroxytryptamine 2B receptor HTR2B 0.0105
427 Substance-P receptor TACR1 0.0105
284 DNA-directed RNA polymerase beta chain rpoB 0.0102
5773 DNA-directed RNA polymerase beta chain rpoB 0.0102
6137 Multidrug resistance-associated protein 6 ABCC6 0.0102
32 Vascular endothelial growth factor receptor 1 FLT1 0.0101
4120 NADPH--cytochrome P450 reductase POR 0.01
161 Tubulin beta chain TUBB 0.0098
312 Tubulin beta chain TUB2 0.0098
474 Acetylcholinesterase ACHE 0.0098
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0098
163 D(1B) dopamine receptor DRD5 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0097
365 Dihydrofolate reductase DHFR 0.0097
2381 Dihydrofolate reductase DFR1 0.0097
2833 Dihydrofolate reductase Not Available 0.0097
2931 Dihydrofolate reductase folA 0.0097
3544 Dihydrofolate reductase folA 0.0097
3682 Dihydrofolate reductase folA 0.0097
6642 Dihydrofolate reductase folA 0.0097
6756 Dihydrofolate reductase dfrA 0.0097
818 50S ribosomal protein L10 rplJ 0.0095
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0095
1256 5-hydroxytryptamine 6 receptor HTR6 0.0095
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0093
777 Tumor necrosis factor TNF 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0092
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0091
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0091
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.009
6020 Aldehyde oxidase AOX1 0.0089
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
295 Carbonic anhydrase 1 CA1 0.0088
1656 CYP2B protein CYP2B 0.0088
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0088
869 Estrogen receptor beta ESR2 0.0086
4203 Histamine N-methyltransferase HNMT 0.0086
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0086
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0086
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0086
2112 Toll-like receptor 9 TLR9 0.0086
124 Histamine H2 receptor HRH2 0.0085
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0083
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
1050 Bile salt sulfotransferase SULT2A1 0.0082
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.008
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.008
705 Glutamate receptor 1 GRIA1 0.0078
738 Monocarboxylate transporter 1 SLC16A1 0.0078
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
814 Ryanodine receptor 1 RYR1 0.0077
165 FL cytokine receptor FLT3 0.0077
131 Synaptic vesicular amine transporter SLC18A2 0.0076
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0075
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0075
1541 Metalloproteinase mmp20 0.0074
477 DNA topoisomerase 4 subunit A parC 0.0074
886 DNA topoisomerase 4 subunit A parC 0.0074
6226 DNA topoisomerase 4 subunit A parC 0.0074
2539 Tubulin alpha-1 chain TUBA4A 0.0073
592 Carbonic anhydrase 4 CA4 0.0073
404 DNA gyrase subunit A gyrA 0.0073
6224 DNA gyrase subunit A gyrA 0.0073
528 5-hydroxytryptamine 1E receptor HTR1E 0.0072
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0072
1757 Myeloperoxidase MPO 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
1178 Adenosine A2a receptor ADORA2A 0.0071
88 Retinoic acid receptor RXR-beta RXRB 0.007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
6085 Fatty acid-binding protein, intestinal FABP2 0.0069
49 Endothelin B receptor EDNRB 0.0069
275 Arachidonate 5-lipoxygenase ALOX5 0.0068
4237 50S ribosomal protein L22 rplV 0.0068
3086 Plasmepsin-2 Not Available 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0067
1196 Complement decay-accelerating factor CD55 0.0067
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0067
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0067
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0067
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0066
1852 Microtubule-associated protein 2 MAP2 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0064
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0064
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0064
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0063
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0063
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0063
16 Adenosine A1 receptor ADORA1 0.0063
133 Dihydropterate synthase sulI 0.0063
273 Apoptosis regulator Bcl-2 BCL2 0.0063
54 Prothrombin F2 0.0062
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
4122 Histone deacetylase 2 HDAC2 0.0062
3810 Catechol O-methyltransferase COMT 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
373 Transthyretin TTR 0.006
7 Nitric oxide synthase, inducible NOS2 0.006
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
174 Sigma 1-type opioid receptor SIGMAR1 0.0059
5300 Antigen peptide transporter 1 TAP1 0.0059
2808 Chloramphenicol acetyltransferase 3 cat3 0.0058
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0058
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0057
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0057
1629 Transcription factor AP-1 JUN 0.0056
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0055
153 Dopamine beta-hydroxylase DBH 0.0055
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0055
239 Coagulation factor X F10 0.0055
6506 Stathmin-4 STMN4 0.0055
357 Carbonic anhydrase 2 CA2 0.0055
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0055
3932 Glutathione S-transferase A2 GSTA2 0.0054
780 Retinoic acid receptor RXR-gamma RXRG 0.0054
823 Fibroblast growth factor receptor 2 FGFR2 0.0054
319 Opioid receptor, sigma 1 OPRS1 0.0054
4238 50S ribosomal protein L4 rplD 0.0054
5578 50S ribosomal protein L4 rplD 0.0054
6173 50S ribosomal protein L4 rplD 0.0054
6219 50S ribosomal protein L4 rplD 0.0054
856 Vitamin D3 receptor VDR 0.0054
1618 High affinity nerve growth factor receptor NTRK1 0.0053
3601 Dihydropteroate synthase 1 folP1 0.0053
3807 Dihydropteroate synthase 1 folP1 0.0053
3808 Dihydropteroate synthase 2 folP2 0.0053
3947 Xanthine dehydrogenase/oxidase XDH 0.0053
2417 Chloramphenicol acetyltransferase cat 0.0053
3278 Chloramphenicol acetyltransferase cat 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0053
2810 Dr hemagglutinin structural subunit draA 0.0052
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1630 Integrin beta-2 ITGB2 0.0051
976 Platelet glycoprotein IX GP9 0.0051
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0051
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
1275 Estrogen sulfotransferase SULT1E1 0.005
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0049
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0049
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0049
4311 tRNA TRDMT1 0.0049
4325 tRNA trmD 0.0049
4328 tRNA trmD 0.0049
173 Toll-like receptor 7 TLR7 0.0049
1192 Sulfotransferase 1A1 SULT1A1 0.0048
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0047
921 Glutamate receptor 2 GRIA2 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0046
6126 Carbonic anhydrase 7 CA7 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
162 Retinoic acid receptor gamma-1 RARG 0.0045
518 Peroxidase/catalase T katG 0.0045
482 Glycine receptor subunit alpha-1 GLRA1 0.0044
6048 Troponin C, skeletal muscle TNNC2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3809 Estrogen-related receptor gamma ESRRG 0.0043
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0043
1517 Beta-3 adrenergic receptor ADRB3 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
6044 Serum paraoxonase/lactonase 3 PON3 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0039
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0039
572 Integrin alpha-L ITGAL 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
5787 Angiopoietin-1 receptor TEK 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
719 Retinoic acid receptor responder protein 1 RARRES1 0.0038
770 Retinoic acid-induced protein 3 GPRC5A 0.0038
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
267 Plasminogen activator inhibitor 1 SERPINE1 0.0033
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0033
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0033
5880 Thrombopoietin receptor MPL 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
164 Histamine H4 receptor HRH4 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1864 RET proto-oncogene RET 0.003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.003
904 Glutathione S-transferase P GSTP1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.003
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.003
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.003
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
1992 Vitamin D-binding protein GC 0.0029
6824 Tyrosine-protein kinase Lyn LYN 0.0029
6146 High affinity copper uptake protein 1 SLC31A1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0029
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0028
33 Cystine/glutamate transporter SLC7A11 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
4192 DNA topoisomerase 2-beta TOP2B 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
537 ATP synthase delta chain, mitochondrial ATP5D 0.0027
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0026
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
6432 Transporter snf 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
563 Thyroid peroxidase TPO 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0024
936 Ephrin type-A receptor 2 EPHA2 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
730 Retinoic acid receptor alpha RARA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1039 Histone deacetylase 9 HDAC9 0.002
4217 Telomerase reverse transcriptase TERT 0.002
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
908 Glutathione S-transferase theta-1 GSTT1 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
2207 Rhodopsin RHO 0.0016
3233 Bile acid receptor NR1H4 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3957 Adenosine deaminase ADA 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0014
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6218 Pannexin-1 PANX1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
2021 Thrombomodulin THBD 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0012
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0012
3673 Fumarate reductase flavoprotein subunit fccA 0.0012
4912 Fumarate reductase flavoprotein subunit ifcA 0.0012
6549 Fumarate reductase flavoprotein subunit frdA 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
734 D1 dopamine receptor-interacting protein calcyon CALY 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6677 Myelin P2 protein PMP2 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
3221 Cytochrome c4 cc4 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0006
1507 Cytochrome c CYCS 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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