DT-Web: DB08864

Identification

Name

Rilpivirine

Accession Number

DB08864

Type

small molecule

Description

Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine, a class of molecules that resemble pyrimidine nucleotides found in DNA. Because of its flexible chemical structure, resistance of rilpivirine is less likely to develop than other NNRTI's. FDA approved on May 20, 2011.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antiviral Agents

Molecular Weight

366.4185

Groups

approved

Monoisotopic Weight

366.159294606

Pharmacology

Indication

Treatment of HIV-1 infections in treatment-naive patients with HIV-1 RNA <=100,000 copies/mL in combination with at least 2 other antiretroviral agents.

Mechanism of action

Rilpivirine is an NNRTI which binds to reverse transcriptase which results in a block in RNA and DNA- dependent DNA polymerase activities. One such activity is HIV-1 replication. Intracellular phosphorylation is not necessary for its antiviral activity. Because of the structure of rilpivirine is flexible around the aromatic rings, the molecule can have multiple conformations so that can bind to residues in the reverse transcriptase enzyme which have a lower mutation rate.

Absorption

Rilpivirine demonstrates dose-dependent pharmacokinetics and does not change between subscutaneous, IV, and intramuscular administration. Absorption increases with meals. Tmax, oral administration = 4 hours;

Protein binding

>99% protein bound.

Biotransformation

Mainly hepatically metabolized by CYP3A4. Because it is highly protein bound, its free plasma concentration is very small thus is unlikely to inhibit cytochrome proteins to a clinically relevant degree despite being an inhibitor of CYP3A4, CYP2C19, and CYP2B6.

Route of elimination

Excreted fecally (85%, 25% as unchanged drug) and urine (6%, <1% as unchanged drug)

Toxicity

Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.

Affected organisms

Human Immunodeficiency Virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Carbamazepine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Delavirdine	Concentration of rilpivirine increases by affecting CYP3A4 metabolism. Concomitant use is contraindicated. Rilpivirine should not be used with other NNRTI's.
Dexamethasone	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Efavirenz	Concentration of rilpivirine decreases by affecting CYP3A4 metabolism. Concomitant use is contraindicated. Rilpivirine should not be used with other NNRTI's.
Esomeprazole	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Etravirine	Rilpivirine, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy. Use of rilpivirine and other NNRTIs is containdicated.
Famotidine	Histamine-2 receptor antagonists increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Lansoprazole	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Methadone	Dose adjustment and clinical monitoring of rilpivirine may be necessary if coadministered with methadone.
Omeprazole	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Oxcarbazepine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Pantoprazole	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Phenobarbital	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Phenytoin	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Rabeprazole	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Ranitidine	Histamine-2 receptor antagonists increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Rifabutin	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Rifampin	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Rifapentine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.

Food Interactions

Absorption is increased by 40% if taken with food.
Co-administration with St. John's wort decreases levels of rilpivirine by inducing CYP3A4 metabolism. Use is contraindicated.

Reverse transcriptase
Name	Reverse transcriptase
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	Garvey L, Winston A: Rilpivirine: a novel non-nucleoside reverse transcriptase inhibitor. Expert Opin Investig Drugs. 2009 Jul;18(7):1035-41. doi: 10.1517/13543780903055056. - Pubmed
DTHybrid score	Not Available
Nuclear receptor subfamily 1 group I member 2
Name	Nuclear receptor subfamily 1 group I member 2
Gene Name	NR1I2
Pharmacological action	unknown
Actions	agonist
References	Sharma D, Lau AJ, Sherman MA, Chang TK: Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors. Biochem Pharmacol. 2013 Apr 9. pii: S0006-2952(13)00224-4. doi: 10.1016/j.bcp.2013.04.002. - Pubmed
DTHybrid score	0.3369

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.6497
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.3898
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.3143
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inducer
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.4247

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.4981
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.3021
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.3581
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	inhibitor
References	Weiss J, Haefeli WE: Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. doi: 10.1016/j.ijantimicag.2013.01.004. Epub 2013 Feb 18. - Pubmed
DTHybrid score	0.2526

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.325
4119	Cytochrome P450 2D6	CYP2D6	0.2869
4924	Cytochrome P450 2C8	CYP2C8	0.2629
4118	Cytochrome P450 3A5	CYP3A5	0.2376
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1654
6107	Cytochrome P450 3A7	CYP3A7	0.1551
6013	Cytochrome P450 2E1	CYP2E1	0.139
6024	Cytochrome P450 1A1	CYP1A1	0.1375
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1348
587	Serum albumin	ALB	0.1305
862	Multidrug resistance-associated protein 1	ABCC1	0.1014
5718	Cytochrome P450 2A6	CYP2A6	0.0955
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0826
20	Prostaglandin G/H synthase 1	PTGS1	0.0819
776	Bile salt export pump	ABCB11	0.0762
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0762
1729	Solute carrier family 22 member 6	SLC22A6	0.0733
6142	Solute carrier family 22 member 8	SLC22A8	0.0682
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0656
1898	Cytochrome P450 1B1	CYP1B1	0.0645
6145	Solute carrier family 22 member 1	SLC22A1	0.064
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0612
284	DNA-directed RNA polymerase beta chain	rpoB	0.059
5773	DNA-directed RNA polymerase beta chain	rpoB	0.059
492	Histamine H1 receptor	HRH1	0.0582
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0547
3811	Cytochrome P450 19A1	CYP19A1	0.054
6106	Cytochrome P450 2C18	CYP2C18	0.0529
136	Estrogen receptor	ESR1	0.0525
2164	Multidrug resistance-associated protein 4	ABCC4	0.0516
824	Sodium-dependent serotonin transporter	SLC6A4	0.0493
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0488
6141	Sodium/bile acid cotransporter	SLC10A1	0.047
6144	Solute carrier family 22 member 2	SLC22A2	0.0458
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0444
70	Type-1 angiotensin II receptor	AGTR1	0.0444
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0432
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0431
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0431
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0427
6148	Multidrug resistance-associated protein 7	ABCC10	0.0419
556	Alpha-1A adrenergic receptor	ADRA1A	0.0403
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0401
6143	Solute carrier family 22 member 7	SLC22A7	0.0395
731	HIV-1 protease	HIV-1 protease	0.0384
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0382
275	Arachidonate 5-lipoxygenase	ALOX5	0.0363
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0359
831	D(2) dopamine receptor	DRD2	0.0354
3587	Gastrotropin	FABP6	0.0351
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0341
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0341
844	Epidermal growth factor receptor	EGFR	0.0339
29	Tubulin beta-1 chain	TUBB1	0.0338
468	Cytochrome P450 4A11	CYP4A11	0.0321
817	DNA topoisomerase 2-alpha	TOP2A	0.0318
118	Organic cation/carnitine transporter 2	SLC22A5	0.0318
871	Glucocorticoid receptor	NR3C1	0.0317
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0309
318	Alpha-2A adrenergic receptor	ADRA2A	0.0308
1024	Solute carrier family 22 member 11	SLC22A11	0.0307
290	Prostaglandin G/H synthase 2	PTGS2	0.0298
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0293
3941	Amine oxidase [flavin-containing] A	MAOA	0.029
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0285
6147	Solute carrier family 22 member 3	SLC22A3	0.0281
713	Sodium-dependent dopamine transporter	SLC6A3	0.0272
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.027
260	Cytochrome P450 51	ERG11	0.0269
761	Cytochrome P450 51	ERG11	0.0269
3163	Cytochrome P450 51	cyp51	0.0269
3923	Cholinesterase	BCHE	0.0266
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0266
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0262
36	Insulin receptor	INSR	0.0258
632	Alpha-1B adrenergic receptor	ADRA1B	0.025
23	D(1A) dopamine receptor	DRD1	0.0245
4604	Liver carboxylesterase 1	CES1	0.0243
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0242
2907	Oxysterols receptor LXR-beta	NR1H2	0.0242
6283	Oxysterols receptor LXR-alpha	NR1H3	0.0242
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0237
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0233
504	Mast/stem cell growth factor receptor	KIT	0.0233
193	Beta-1 adrenergic receptor	ADRB1	0.0231
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0229
766	Beta-2 adrenergic receptor	ADRB2	0.0229
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0226
1353	DNA topoisomerase 1	TOP1	0.0225
3552	DNA topoisomerase 1	topA	0.0225
6136	Multidrug resistance-associated protein 5	ABCC5	0.0225
6137	Multidrug resistance-associated protein 6	ABCC6	0.0222
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0222
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0221
373	Transthyretin	TTR	0.0221
758	Thyroid hormone receptor alpha	THRA	0.022
833	Organic cation/carnitine transporter 1	SLC22A4	0.0219
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0218
847	Mu-type opioid receptor	OPRM1	0.0216
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0216
26	Vascular endothelial growth factor receptor 3	FLT4	0.0215
88	Retinoic acid receptor RXR-beta	RXRB	0.021
273	Apoptosis regulator Bcl-2	BCL2	0.021
869	Estrogen receptor beta	ESR2	0.0209
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0208
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0207
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0207
32	Vascular endothelial growth factor receptor 1	FLT1	0.0206
6031	Cytochrome P450 3A43	CYP3A43	0.0206
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0204
789	Alpha-1D adrenergic receptor	ADRA1D	0.0204
1852	Microtubule-associated protein 2	MAP2	0.0203
2539	Tubulin alpha-1 chain	TUBA4A	0.0203
6228	Nuclear receptor coactivator 1	NCOA1	0.0203
756	Sex hormone-binding globulin	SHBG	0.0201
6241	Nuclear receptor coactivator 2	NCOA2	0.0201
465	Calmodulin	CALM1	0.0201
6220	Aryl hydrocarbon receptor	AHR	0.0201
33	Cystine/glutamate transporter	SLC7A11	0.02
346	Thyroid hormone receptor beta-1	THRB	0.0197
594	Thyroxine-binding globulin	SERPINA7	0.0194
4120	NADPH--cytochrome P450 reductase	POR	0.0193
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0193
5923	Microtubule-associated protein tau	MAPT	0.0192
5924	Microtubule-associated protein 4	MAP4	0.0192
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0192
407	Vascular endothelial growth factor receptor 2	KDR	0.0191
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.019
6167	Organic solute transporter subunit beta	OSTB	0.019
6166	Organic solute transporter subunit alpha	OSTA	0.019
122	P2Y purinoceptor 12	P2RY12	0.0188
3939	Amine oxidase [flavin-containing] B	MAOB	0.0186
467	Delta-type opioid receptor	OPRD1	0.0184
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0183
477	DNA topoisomerase 4 subunit A	parC	0.0181
886	DNA topoisomerase 4 subunit A	parC	0.0181
6226	DNA topoisomerase 4 subunit A	parC	0.0181
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0181
404	DNA gyrase subunit A	gyrA	0.0178
6224	DNA gyrase subunit A	gyrA	0.0178
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0178
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0178
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0176
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0172
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0172
696	Kappa-type opioid receptor	OPRK1	0.0172
738	Monocarboxylate transporter 1	SLC16A1	0.0169
117	Sterol O-acyltransferase 1	SOAT1	0.0164
6182	Cytochrome P450 2J2	CYP2J2	0.0164
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0163
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0161
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0161
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0161
818	50S ribosomal protein L10	rplJ	0.016
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.016
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0158
638	D(3) dopamine receptor	DRD3	0.0158
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0157
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0155
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0152
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0151
629	Alpha-2B adrenergic receptor	ADRA2B	0.015
146	Androgen receptor	AR	0.0148
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0148
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0148
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0144
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0143
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0142
904	Glutathione S-transferase P	GSTP1	0.0142
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0141
3947	Xanthine dehydrogenase/oxidase	XDH	0.014
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.014
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0136
124	Histamine H2 receptor	HRH2	0.0136
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0135
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0133
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0131
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0129
6085	Fatty acid-binding protein, intestinal	FABP2	0.0127
1757	Myeloperoxidase	MPO	0.0126
161	Tubulin beta chain	TUBB	0.0124
312	Tubulin beta chain	TUB2	0.0124
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0123
378	Alpha-2C adrenergic receptor	ADRA2C	0.0122
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0121
614	Progesterone receptor	PGR	0.012
777	Tumor necrosis factor	TNF	0.012
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0119
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0118
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0117
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0116
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0111
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0111
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0111
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0111
952	Dipeptidyl peptidase 4	DPP4	0.0111
199	Monocarboxylate transporter 8	SLC16A2	0.0111
1656	CYP2B protein	CYP2B	0.011
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0109
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0108
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0108
6020	Aldehyde oxidase	AOX1	0.0107
5880	Thrombopoietin receptor	MPL	0.0106
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0104
992	Protein tyrosine kinase 2 beta	PTK2B	0.0104
3932	Glutathione S-transferase A2	GSTA2	0.0103
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0102
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0102
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0101
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0101
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0101
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0101
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.01
6014	Cytochrome P450 2A13	CYP2A13	0.0099
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0099
432	D(4) dopamine receptor	DRD4	0.0099
716	5-hydroxytryptamine 7 receptor	HTR7	0.0099
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4773	Deoxycytidine kinase	DCK	0.0096
571	Melatonin receptor type 1A	MTNR1A	0.0096
362	Melatonin receptor type 1B	MTNR1B	0.0096
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0094
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0094
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0093
1192	Sulfotransferase 1A1	SULT1A1	0.0092
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0092
232	Corticosteroid-binding globulin	SERPINA6	0.0091
380	Cytochrome P450 17A1	CYP17A1	0.0089
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0089
474	Acetylcholinesterase	ACHE	0.0089
283	SEC14-like protein 2	SEC14L2	0.0087
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0087
86	SEC14-like protein 4	SEC14L4	0.0087
375	SEC14-like protein 3	SEC14L3	0.0087
4076	Diacylglycerol kinase alpha	DGKA	0.0087
174	Sigma 1-type opioid receptor	SIGMAR1	0.0087
563	Thyroid peroxidase	TPO	0.0087
1010	Cytochrome P450 51A1	CYP51A1	0.0086
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0086
3856	Fibroblast growth factor receptor 3	FGFR3	0.0086
68	Cannabinoid receptor 1	CNR1	0.0084
811	Translocator protein	TSPO	0.0083
16	Adenosine A1 receptor	ADORA1	0.0083
1650	Heme carrier protein 1	SLC46A1	0.0083
3809	Estrogen-related receptor gamma	ESRRG	0.0082
708	Alpha-tocopherol transfer protein	TTPA	0.0082
5787	Angiopoietin-1 receptor	TEK	0.0081
482	Glycine receptor subunit alpha-1	GLRA1	0.008
165	FL cytokine receptor	FLT3	0.008
427	Substance-P receptor	TACR1	0.008
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.008
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0079
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0079
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0079
1178	Adenosine A2a receptor	ADORA2A	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0077
6151	Monocarboxylate transporter 10	SLC16A10	0.0077
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0077
997	Protein kinase C beta type	PRKCB	0.0077
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0077
908	Glutathione S-transferase theta-1	GSTT1	0.0076
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0076
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0076
6149	Solute carrier family 22 member 10	SLC22A10	0.0075
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0075
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0075
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0075
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0075
3810	Catechol O-methyltransferase	COMT	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
6146	High affinity copper uptake protein 1	SLC31A1	0.0074
1618	High affinity nerve growth factor receptor	NTRK1	0.0074
4122	Histone deacetylase 2	HDAC2	0.0073
921	Glutamate receptor 2	GRIA2	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
899	Glutathione S-transferase Mu 3	GSTM3	0.0072
905	Glutathione transferase omega-1	GSTO1	0.0072
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0072
705	Glutamate receptor 1	GRIA1	0.0071
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0071
768	FK506-binding protein 1A	FKBP1A	0.007
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.007
2449	Tubulin alpha-3 chain	TUBA1A	0.007
365	Dihydrofolate reductase	DHFR	0.007
2381	Dihydrofolate reductase	DFR1	0.007
2833	Dihydrofolate reductase	Not Available	0.007
2931	Dihydrofolate reductase	folA	0.007
3544	Dihydrofolate reductase	folA	0.007
3682	Dihydrofolate reductase	folA	0.007
6642	Dihydrofolate reductase	folA	0.007
6756	Dihydrofolate reductase	dfrA	0.007
24	Thymidylate synthase	TMP1	0.007
359	Thymidylate synthase	TYMS	0.007
2626	Thymidylate synthase	thyA	0.007
2729	Thymidylate synthase	thyA	0.007
5352	Thymidylate synthase	THYA	0.007
1970	Protein kinase C alpha type	PRKCA	0.007
3917	Methylenetetrahydrofolate reductase	MTHFR	0.007
1760	Aminopeptidase N	ANPEP	0.0069
6843	Aminopeptidase N	pepN	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
823	Fibroblast growth factor receptor 2	FGFR2	0.0068
293	Gamma-glutamyl hydrolase	GGH	0.0068
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0068
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0067
183	Vascular endothelial growth factor A	VEGFA	0.0067
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0067
163	D(1B) dopamine receptor	DRD5	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0065
239	Coagulation factor X	F10	0.0065
810	Heme oxygenase 1	HMOX1	0.0065
3391	Heme oxygenase 1	pbsA1	0.0065
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0064
6432	Transporter	snf	0.0063
6044	Serum paraoxonase/lactonase 3	PON3	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0063
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0062
6138	Multidrug resistance protein 3	ABCB4	0.0062
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0059
936	Ephrin type-A receptor 2	EPHA2	0.0059
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0059
469	Annexin A1	ANXA1	0.0059
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0059
6163	Copper-transporting ATPase 2	ATP7B	0.0059
6165	Copper-transporting ATPase 1	ATP7A	0.0059
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
737	Mineralocorticoid receptor	NR3C2	0.0057
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0057
106	Cannabinoid receptor 2	CNR2	0.0057
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0057
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
1630	Integrin beta-2	ITGB2	0.0056
896	Glutathione S-transferase Mu 1	GSTM1	0.0056
1517	Beta-3 adrenergic receptor	ADRB3	0.0056
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0055
592	Carbonic anhydrase 4	CA4	0.0055
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0054
891	Dihydropteroate synthase	folP	0.0054
5359	Dihydropteroate synthase	folP	0.0054
7175	Dihydropteroate synthase	sulI	0.0054
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0054
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0054
94	5-hydroxytryptamine 4 receptor	HTR4	0.0054
6102	Arylamine N-acetyltransferase 2	NAT2	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
856	Vitamin D3 receptor	VDR	0.0053
5818	Folate receptor alpha	FOLR1	0.0052
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0052
49	Endothelin B receptor	EDNRB	0.0052
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0052
4192	DNA topoisomerase 2-beta	TOP2B	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0052
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0052
712	Tubulin alpha chain	TUB1	0.0052
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0052
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
319	Opioid receptor, sigma 1	OPRS1	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
295	Carbonic anhydrase 1	CA1	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.005
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0049
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0049
6043	Putative G-protein coupled receptor 44	GPR44	0.0049
6168	Solute carrier family 22 member 16	SLC22A16	0.0048
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0048
1525	Heparin-binding growth factor 2	FGF2	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0047
7	Nitric oxide synthase, inducible	NOS2	0.0047
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0047
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0046
814	Ryanodine receptor 1	RYR1	0.0046
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0046
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0046
517	Alcohol dehydrogenase 1C	ADH1C	0.0046
173	Toll-like receptor 7	TLR7	0.0046
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0045
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0044
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0044
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0044
4103	Proteasome subunit beta type 2	PSMB2	0.0043
4102	Proteasome subunit beta type 5	PSMB5	0.0043
4101	Proteasome subunit beta type 1	PSMB1	0.0043
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0043
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0042
2391	Ferrochelatase	hemH	0.0042
6502	Ferrochelatase	DKFZp686P18130	0.0042
1591	Ferrochelatase, mitochondrial	FECH	0.0042
760	Fibroblast growth factor 1	FGF1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0042
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0042
357	Carbonic anhydrase 2	CA2	0.0041
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0041
84	Nuclear receptor 0B1	NR0B1	0.0041
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1629	Transcription factor AP-1	JUN	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0039
6824	Tyrosine-protein kinase Lyn	LYN	0.0039
581	Cytochrome P450 2R1	CYP2R1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
131	Synaptic vesicular amine transporter	SLC18A2	0.0039
5798	Mitogen-activated protein kinase 11	MAPK11	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
780	Retinoic acid receptor RXR-gamma	RXRG	0.0038
85	Growth hormone receptor	GHR	0.0038
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0037
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0037
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0037
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0037
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0037
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0037
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0037
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0037
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0037
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0037
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0037
6559	Cytochrome c oxidase subunit 2	ctaC	0.0037
6669	Cytochrome c oxidase subunit 2	ctaC	0.0037
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0037
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0037
6558	Cytochrome c oxidase subunit 1	ctaD	0.0037
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0037
2599	Tyrosine-protein kinase HCK	HCK	0.0036
4311	tRNA	TRDMT1	0.0036
4325	tRNA	trmD	0.0036
4328	tRNA	trmD	0.0036
267	Plasminogen activator inhibitor 1	SERPINE1	0.0036
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0036
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0036
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
751	Potassium channel subfamily K member 6	KCNK6	0.0036
4217	Telomerase reverse transcriptase	TERT	0.0035
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0035
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0035
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0035
3957	Adenosine deaminase	ADA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
2540	Choloylglycine hydrolase	cbh	0.0034
518	Peroxidase/catalase T	katG	0.0033
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6221	Steroid hormone receptor ERR1	ESRRA	0.0033
572	Integrin alpha-L	ITGAL	0.0033
5626	Nucleoside diphosphate kinase B	NME2	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
172	Potassium channel subfamily K member 1	KCNK1	0.0033
1864	RET proto-oncogene	RET	0.0032
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0032
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0032
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0032
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0032
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0032
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
6501	Fatty acid-binding protein, liver	FABP1	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
484	Tyrosine-protein kinase ABL2	ABL2	0.0031
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
564	Cellular retinoic acid-binding protein 1	CRABP1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
702	UMP-CMP kinase	CMPK1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
444	Alcohol dehydrogenase 1B	ADH1B	0.003
251	Alcohol dehydrogenase 1A	ADH1A	0.003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
6174	50S ribosomal protein L32	rpmF	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
291	Nitric-oxide synthase, endothelial	NOS3	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0028
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0028
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
2320	Thymidine kinase, cytosolic	TK1	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
820	Glycine receptor subunit alpha-2	GLRA2	0.0028
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0028
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0028
634	Squalene monooxygenase	SQLE	0.0028
7196	Squalene monooxygenase	ERG1	0.0028
1992	Vitamin D-binding protein	GC	0.0028
2216	Fibroblast growth factor receptor 4	FGFR4	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0027
5294	Nucleoside diphosphate kinase A	NME1	0.0027
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0027
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0027
976	Platelet glycoprotein IX	GP9	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1050	Bile salt sulfotransferase	SULT2A1	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0026
6500	Phospholipase A2	PLA2G1B	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1648	Elastin	ELN	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
6859	Protein S100-A4	S100A4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6837	Serine/threonine-protein kinase 17B	STK17B	0.0025
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0025
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
162	Retinoic acid receptor gamma-1	RARG	0.0025
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0025
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0024
3937	Fatty-acid amide hydrolase	FAAH	0.0024
4226	Uridine phosphorylase 2	UPP2	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
65	Matrix metalloproteinase-9	Not Available	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0023
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0023
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0023
489	Monocarboxylate transporter 2	SLC16A7	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
4225	Uridine phosphorylase 1	UPP1	0.0022
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0022
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0022
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0022
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
54	Prothrombin	F2	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0022
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0022
1039	Histone deacetylase 9	HDAC9	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0021
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0021
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0021
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
413	Amidophosphoribosyltransferase	PPAT	0.0021
2515	Amidophosphoribosyltransferase	purF	0.0021
3714	Amidophosphoribosyltransferase	purF	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0021
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.002
4203	Histamine N-methyltransferase	HNMT	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
153	Dopamine beta-hydroxylase	DBH	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0019
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
558	Solute carrier family 12 member 1	SLC12A1	0.0018
1253	Interferon gamma	IFNG	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0018
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0018
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0018
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0018
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0018
1374	Natriuretic peptides B	NPPB	0.0018
1827	Gap junction alpha-1 protein	GJA1	0.0018
1908	Vascular cell adhesion protein 1	VCAM1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
3830	Calreticulin	CALR	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
3639	Thymidine phosphorylase	deoA	0.0017
3936	Thymidine phosphorylase	TYMP	0.0017
76	Nitric-oxide synthase, brain	NOS1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0016
1243	Cathepsin D	CTSD	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
164	Histamine H4 receptor	HRH4	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6755	Poliovirus receptor	PVR	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
3601	Dihydropteroate synthase 1	folP1	0.0015
3807	Dihydropteroate synthase 1	folP1	0.0015
3808	Dihydropteroate synthase 2	folP2	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
2207	Rhodopsin	RHO	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
1275	Estrogen sulfotransferase	SULT1E1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
569	Retinal dehydrogenase 2	ALDH1A2	0.0013
6218	Pannexin-1	PANX1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
2021	Thrombomodulin	THBD	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
268	Adenosine A2b receptor	ADORA2B	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
2298	Cytochrome P450-cam	camC	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
3221	Cytochrome c4	cc4	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
798	Osteocalcin	BGLAP	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4692	A/G-specific adenine glycosylase	mutY	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4943	Cytochrome c6	petJ	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4909	CooA protein	cooA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
5000	HemO	hemO	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4935	Cytochrome c-554	cycA1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4972	P450cin	cinA	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4961	Hemophore HasA	hasA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
4952	Catalase/peroxidase	katA	0.0004
3093	Catalase HPII	katE	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
292	Activin receptor type-1	ACVR1	0.0003
4920	Peroxidase/catalase	katG	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4990	PpcA	ppcA	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08864 - Rilpivirine

Targets

Enzymes

Transporters

Predictions