DT-Web: DB00448

Identification

Name

Lansoprazole

Accession Number

DB00448 (APRD00077)

Type

small molecule

Description

Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by TAP Pharmaceutical Products. Lansoprazole has been marketed for many years and is one of several PPI's available.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

369.361

Groups

approved

Monoisotopic Weight

369.075882012

Pharmacology

Indication

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.

Mechanism of action

Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H₂-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H⁺,K⁺)-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

Absorption

The absorption of lansoprazole is rapid, with mean C_max occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%.

Protein binding

97%

Biotransformation

Hepatic. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of lansoprazole). These metabolites have very little or no antisecretory activity. Lansoprazole is thought to be transformed into two active species which inhibit acid secretion by (H⁺,K⁺)-ATPase within the parietal cell canaliculus, but are not present in the systemic circulation.

Route of elimination

Following single-dose oral administration of PREVACID, virtually no unchanged lansoprazole was excreted in the urine. In one study, after a single oral dose of 14C-lansoprazole, approximately one-third of the administered radiation was excreted in the urine and two-thirds was recovered in the feces. This implies a significant biliary excretion of the lansoprazole metabolites.

Toxicity

Symptoms of overdose include abdominal pain, nausea and diarrhea.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	This gastric pH modifier decreases the levels/effects of atazanavir
Bosutinib	Concomitant lansoprazole (PPI) decreased bosutinib Cmax by 46% and AUC by 26% compared to bosutinib alone. Consider using short-acting antacids or H2 blockers instead of PPIs to avoid a reduction in bosutinib exposure. Separate antacid or H2 blocker dosing and BOSULIF dosing by more than 2 hours.
Cefditoren	Proton pump inhibitors such as lansoprazole may decrease the serum concentration of cefditoren. If possible, avoid use of cefditoren with proton pump inhibitors (PPIs). Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of PPIs can not be avoided.
Clopidogrel	Lansoprazole may decrease serum concentrations of the active metabolite(s) of clopidogrel. Due to the possible risk for impaired clopidogrel effectiveness with this combination, clinicians should carefully consider the need for concurrent lansoprazole therapy in patients receiving clopidogrel. Monitor response to clopidogrel closely when using clopidogrel with lansoprazole. Whether there are differences among individual proton pump inhibitors is unclear. Other acid-lowering therapies (e.g., H2-receptor antagonists, antacids, etc.) do not appear to share this interaction with clopidogrel.
Enoxacin	Lansoprazole may decrease the absorption of enoxacin.
Indinavir	Omeprazole decreases the absorption of indinavir
Itraconazole	The proton pump inhibitor, lansoprazole, may decrease the absorption of itraconazole.
Ketoconazole	The proton pump inhibitor, lansoprazole, may decrease the absorption of ketoconazole.
Prasugrel	Lansoprazole is a CYP2C19 substrate which decreases AUC and Cmax of prasugrel. Despite these decreases, there was no significant reduction of inhibition of platelet aggregation.
Rilpivirine	Proton-pump inhibitors increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Sucralfate	Sucralfate decreases the effect of lansoprazole

Food Interactions

Food reduces bioavailabilty, but this has very little clinical impact.
Avoid alcohol.
Take 30-60 minutes before meals.

Potassium-transporting ATPase alpha chain 1
Name	Potassium-transporting ATPase alpha chain 1
Gene Name	ATP4A
Pharmacological action	yes
Actions	inhibitor
References	Matheson AJ, Jarvis B: Lansoprazole: an update of its place in the management of acid-related disorders. Drugs. 2001;61(12):1801-33. - Pubmed Langtry HD, Wilde MI: Lansoprazole. An update of its pharmacological properties and clinical efficacy in the management of acid-related disorders. Drugs. 1997 Sep;54(3):473-500. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3368

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9149
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6586
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor,inducer
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6954
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4306
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6531
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2484
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2811
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5127
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6428
Cytochrome P450 4A11
Name	Cytochrome P450 4A11
Gene Name	CYP4A11
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.1705

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Pauli-Magnus C, Rekersbrink S, Klotz U, Fromm MF: Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):551-7. - Pubmed Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T: Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects. Eur J Clin Pharmacol. 2009 Jun;65(6):593-600. Epub 2009 Feb 24. - Pubmed
DTHybrid score	0.5933
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y: Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009 Jan;67(1):44-9. Epub 2008 Nov 17. - Pubmed
DTHybrid score	0.3701

Id	Partner name	Gene Name	Score
4118	Cytochrome P450 3A5	CYP3A5	0.3387
6030	Cytochrome P450 2B6	CYP2B6	0.2889
6013	Cytochrome P450 2E1	CYP2E1	0.2538
6107	Cytochrome P450 3A7	CYP3A7	0.233
5718	Cytochrome P450 2A6	CYP2A6	0.1878
587	Serum albumin	ALB	0.1479
20	Prostaglandin G/H synthase 1	PTGS1	0.1357
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1265
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1243
862	Multidrug resistance-associated protein 1	ABCC1	0.1108
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0984
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0939
492	Histamine H1 receptor	HRH1	0.0899
824	Sodium-dependent serotonin transporter	SLC6A4	0.0844
1729	Solute carrier family 22 member 6	SLC22A6	0.0806
776	Bile salt export pump	ABCB11	0.0783
290	Prostaglandin G/H synthase 2	PTGS2	0.0769
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0764
6145	Solute carrier family 22 member 1	SLC22A1	0.075
6144	Solute carrier family 22 member 2	SLC22A2	0.0708
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0707
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0706
3811	Cytochrome P450 19A1	CYP19A1	0.0702
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0687
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0643
831	D(2) dopamine receptor	DRD2	0.0626
136	Estrogen receptor	ESR1	0.0626
556	Alpha-1A adrenergic receptor	ADRA1A	0.0614
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0614
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0578
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0545
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0544
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0536
766	Beta-2 adrenergic receptor	ADRB2	0.0519
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0512
118	Organic cation/carnitine transporter 2	SLC22A5	0.0507
6142	Solute carrier family 22 member 8	SLC22A8	0.0496
817	DNA topoisomerase 2-alpha	TOP2A	0.0494
193	Beta-1 adrenergic receptor	ADRB1	0.0492
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0486
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0478
871	Glucocorticoid receptor	NR3C1	0.0477
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0475
318	Alpha-2A adrenergic receptor	ADRA2A	0.0462
6143	Solute carrier family 22 member 7	SLC22A7	0.0445
3947	Xanthine dehydrogenase/oxidase	XDH	0.0432
23	D(1A) dopamine receptor	DRD1	0.0431
2164	Multidrug resistance-associated protein 4	ABCC4	0.0426
6147	Solute carrier family 22 member 3	SLC22A3	0.0423
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0414
3923	Cholinesterase	BCHE	0.0412
85	Growth hormone receptor	GHR	0.041
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0408
844	Epidermal growth factor receptor	EGFR	0.0407
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0404
847	Mu-type opioid receptor	OPRM1	0.0404
3941	Amine oxidase [flavin-containing] A	MAOA	0.0402
713	Sodium-dependent dopamine transporter	SLC6A3	0.0396
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0396
6031	Cytochrome P450 3A43	CYP3A43	0.0392
632	Alpha-1B adrenergic receptor	ADRA1B	0.0392
731	HIV-1 protease	HIV-1 protease	0.0391
6148	Multidrug resistance-associated protein 7	ABCC10	0.0384
467	Delta-type opioid receptor	OPRD1	0.0365
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0348
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0348
465	Calmodulin	CALM1	0.0348
6137	Multidrug resistance-associated protein 6	ABCC6	0.0346
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0345
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0344
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0343
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0334
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0329
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0329
696	Kappa-type opioid receptor	OPRK1	0.0327
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0325
260	Cytochrome P450 51	ERG11	0.0325
761	Cytochrome P450 51	ERG11	0.0325
3163	Cytochrome P450 51	cyp51	0.0325
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.032
885	5-hydroxytryptamine 1B receptor	HTR1B	0.032
380	Cytochrome P450 17A1	CYP17A1	0.0317
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0313
833	Organic cation/carnitine transporter 1	SLC22A4	0.031
504	Mast/stem cell growth factor receptor	KIT	0.0299
146	Androgen receptor	AR	0.0286
789	Alpha-1D adrenergic receptor	ADRA1D	0.0285
1757	Myeloperoxidase	MPO	0.0284
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.028
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.028
1024	Solute carrier family 22 member 11	SLC22A11	0.0279
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0274
3939	Amine oxidase [flavin-containing] B	MAOB	0.0273
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0273
6182	Cytochrome P450 2J2	CYP2J2	0.027
638	D(3) dopamine receptor	DRD3	0.027
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0269
6220	Aryl hydrocarbon receptor	AHR	0.0268
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0261
36	Insulin receptor	INSR	0.0258
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0258
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0257
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0253
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0253
122	P2Y purinoceptor 12	P2RY12	0.0253
6136	Multidrug resistance-associated protein 5	ABCC5	0.0251
629	Alpha-2B adrenergic receptor	ADRA2B	0.025
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0249
4120	NADPH--cytochrome P450 reductase	POR	0.0247
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0247
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0246
84	Nuclear receptor 0B1	NR0B1	0.0246
777	Tumor necrosis factor	TNF	0.024
3426	Glutamine synthetase	glnA	0.024
3987	Glutamine synthetase	GLUL	0.024
6141	Sodium/bile acid cotransporter	SLC10A1	0.024
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0236
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0235
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0234
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0234
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0231
70	Type-1 angiotensin II receptor	AGTR1	0.0231
6014	Cytochrome P450 2A13	CYP2A13	0.0228
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0227
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0226
4311	tRNA	TRDMT1	0.0225
4325	tRNA	trmD	0.0225
4328	tRNA	trmD	0.0225
3932	Glutathione S-transferase A2	GSTA2	0.0225
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0223
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0222
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0222
869	Estrogen receptor beta	ESR2	0.0219
373	Transthyretin	TTR	0.0218
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0215
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0213
29	Tubulin beta-1 chain	TUBB1	0.021
378	Alpha-2C adrenergic receptor	ADRA2C	0.0208
4604	Liver carboxylesterase 1	CES1	0.0208
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0201
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0201
1178	Adenosine A2a receptor	ADORA2A	0.02
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0199
6146	High affinity copper uptake protein 1	SLC31A1	0.0198
477	DNA topoisomerase 4 subunit A	parC	0.0198
886	DNA topoisomerase 4 subunit A	parC	0.0198
6226	DNA topoisomerase 4 subunit A	parC	0.0198
1353	DNA topoisomerase 1	TOP1	0.0198
3552	DNA topoisomerase 1	topA	0.0198
16	Adenosine A1 receptor	ADORA1	0.0196
404	DNA gyrase subunit A	gyrA	0.0195
6224	DNA gyrase subunit A	gyrA	0.0195
4203	Histamine N-methyltransferase	HNMT	0.0194
756	Sex hormone-binding globulin	SHBG	0.0194
4228	Keratin, type II cytoskeletal 7	KRT7	0.0194
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0192
614	Progesterone receptor	PGR	0.019
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.019
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0189
407	Vascular endothelial growth factor receptor 2	KDR	0.0188
891	Dihydropteroate synthase	folP	0.0187
5359	Dihydropteroate synthase	folP	0.0187
7175	Dihydropteroate synthase	sulI	0.0187
432	D(4) dopamine receptor	DRD4	0.0186
26	Vascular endothelial growth factor receptor 3	FLT4	0.0182
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.018
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0177
6102	Arylamine N-acetyltransferase 2	NAT2	0.0176
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0175
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0175
32	Vascular endothelial growth factor receptor 1	FLT1	0.0174
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0172
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.017
571	Melatonin receptor type 1A	MTNR1A	0.0169
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0169
362	Melatonin receptor type 1B	MTNR1B	0.0169
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0168
273	Apoptosis regulator Bcl-2	BCL2	0.0167
1010	Cytochrome P450 51A1	CYP51A1	0.0166
124	Histamine H2 receptor	HRH2	0.0166
908	Glutathione S-transferase theta-1	GSTT1	0.0166
904	Glutathione S-transferase P	GSTP1	0.0165
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0163
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0162
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0162
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0162
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0162
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0162
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0162
33	Cystine/glutamate transporter	SLC7A11	0.0161
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
1192	Sulfotransferase 1A1	SULT1A1	0.0158
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0157
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0155
469	Annexin A1	ANXA1	0.0154
474	Acetylcholinesterase	ACHE	0.0153
88	Retinoic acid receptor RXR-beta	RXRB	0.0152
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0152
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0152
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0152
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0152
161	Tubulin beta chain	TUBB	0.0152
312	Tubulin beta chain	TUB2	0.0152
6163	Copper-transporting ATPase 2	ATP7B	0.015
6165	Copper-transporting ATPase 1	ATP7A	0.015
2449	Tubulin alpha-3 chain	TUBA1A	0.0148
820	Glycine receptor subunit alpha-2	GLRA2	0.0148
1629	Transcription factor AP-1	JUN	0.0147
780	Retinoic acid receptor RXR-gamma	RXRG	0.0146
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0146
1852	Microtubule-associated protein 2	MAP2	0.0146
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0145
719	Retinoic acid receptor responder protein 1	RARRES1	0.0145
770	Retinoic acid-induced protein 3	GPRC5A	0.0145
569	Retinal dehydrogenase 2	ALDH1A2	0.0144
811	Translocator protein	TSPO	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
716	5-hydroxytryptamine 7 receptor	HTR7	0.0141
365	Dihydrofolate reductase	DHFR	0.0139
2381	Dihydrofolate reductase	DFR1	0.0139
2833	Dihydrofolate reductase	Not Available	0.0139
2931	Dihydrofolate reductase	folA	0.0139
3544	Dihydrofolate reductase	folA	0.0139
3682	Dihydrofolate reductase	folA	0.0139
6642	Dihydrofolate reductase	folA	0.0139
6756	Dihydrofolate reductase	dfrA	0.0139
482	Glycine receptor subunit alpha-1	GLRA1	0.0138
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0138
1517	Beta-3 adrenergic receptor	ADRB3	0.0137
611	Retinal dehydrogenase 1	ALDH1A1	0.0134
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0134
117	Sterol O-acyltransferase 1	SOAT1	0.0134
921	Glutamate receptor 2	GRIA2	0.0133
738	Monocarboxylate transporter 1	SLC16A1	0.0132
5923	Microtubule-associated protein tau	MAPT	0.0131
5924	Microtubule-associated protein 4	MAP4	0.0131
564	Cellular retinoic acid-binding protein 1	CRABP1	0.013
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0129
4122	Histone deacetylase 2	HDAC2	0.0129
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0129
818	50S ribosomal protein L10	rplJ	0.0128
952	Dipeptidyl peptidase 4	DPP4	0.0128
896	Glutathione S-transferase Mu 1	GSTM1	0.0127
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0127
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0127
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0126
162	Retinoic acid receptor gamma-1	RARG	0.0125
275	Arachidonate 5-lipoxygenase	ALOX5	0.0125
737	Mineralocorticoid receptor	NR3C2	0.0124
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0124
251	Alcohol dehydrogenase 1A	ADH1A	0.0124
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
814	Ryanodine receptor 1	RYR1	0.0121
992	Protein tyrosine kinase 2 beta	PTK2B	0.0121
6085	Fatty acid-binding protein, intestinal	FABP2	0.012
94	5-hydroxytryptamine 4 receptor	HTR4	0.012
163	D(1B) dopamine receptor	DRD5	0.0119
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0118
68	Cannabinoid receptor 1	CNR1	0.0118
6174	50S ribosomal protein L32	rpmF	0.0118
2539	Tubulin alpha-1 chain	TUBA4A	0.0118
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0118
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0117
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0116
48	Pyridoxal kinase	PDXK	0.0116
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0114
7	Nitric oxide synthase, inducible	NOS2	0.0112
444	Alcohol dehydrogenase 1B	ADH1B	0.0112
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0111
1656	CYP2B protein	CYP2B	0.0111
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0111
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0111
823	Fibroblast growth factor receptor 2	FGFR2	0.0111
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0111
4773	Deoxycytidine kinase	DCK	0.011
295	Carbonic anhydrase 1	CA1	0.011
284	DNA-directed RNA polymerase beta chain	rpoB	0.011
5773	DNA-directed RNA polymerase beta chain	rpoB	0.011
183	Vascular endothelial growth factor A	VEGFA	0.0109
1714	Mitogen-activated protein kinase 3	MAPK3	0.0109
2112	Toll-like receptor 9	TLR9	0.0108
936	Ephrin type-A receptor 2	EPHA2	0.0106
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0105
592	Carbonic anhydrase 4	CA4	0.0105
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0104
3810	Catechol O-methyltransferase	COMT	0.0104
232	Corticosteroid-binding globulin	SERPINA6	0.0103
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0102
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0102
4192	DNA topoisomerase 2-beta	TOP2B	0.0101
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0101
6432	Transporter	snf	0.0101
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0101
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.01
1256	5-hydroxytryptamine 6 receptor	HTR6	0.01
427	Substance-P receptor	TACR1	0.01
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.01
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.01
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0099
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0099
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
165	FL cytokine receptor	FLT3	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0097
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0096
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0096
24	Thymidylate synthase	TMP1	0.0096
359	Thymidylate synthase	TYMS	0.0096
2626	Thymidylate synthase	thyA	0.0096
2729	Thymidylate synthase	thyA	0.0096
5352	Thymidylate synthase	THYA	0.0096
49	Endothelin B receptor	EDNRB	0.0096
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0095
517	Alcohol dehydrogenase 1C	ADH1C	0.0095
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0095
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0095
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0094
106	Cannabinoid receptor 2	CNR2	0.0094
5787	Angiopoietin-1 receptor	TEK	0.0094
1569	G1/S-specific cyclin-D1	CCND1	0.0094
6020	Aldehyde oxidase	AOX1	0.0094
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0093
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0092
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0092
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0091
3856	Fibroblast growth factor receptor 3	FGFR3	0.0091
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0091
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
1618	High affinity nerve growth factor receptor	NTRK1	0.0088
3937	Fatty-acid amide hydrolase	FAAH	0.0088
239	Coagulation factor X	F10	0.0088
3830	Calreticulin	CALR	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0087
461	Glycine receptor subunit alpha-3	GLRA3	0.0086
3808	Dihydropteroate synthase 2	folP2	0.0085
3601	Dihydropteroate synthase 1	folP1	0.0085
3807	Dihydropteroate synthase 1	folP1	0.0085
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0083
1176	Mitogen-activated protein kinase 1	MAPK1	0.0083
4103	Proteasome subunit beta type 2	PSMB2	0.0083
4102	Proteasome subunit beta type 5	PSMB5	0.0083
4101	Proteasome subunit beta type 1	PSMB1	0.0083
2236	Casein kinase II subunit alpha	CSNK2A1	0.0082
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0082
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0082
6034	Hydroxyindole O-methyltransferase	ASMT	0.0081
6035	Nuclear receptor ROR-beta	RORB	0.0081
6036	Eosinophil peroxidase	EPX	0.0081
5934	Cytochrome P450 26A1	CYP26A1	0.0081
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0081
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0079
1050	Bile salt sulfotransferase	SULT2A1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
357	Carbonic anhydrase 2	CA2	0.0078
3957	Adenosine deaminase	ADA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
268	Adenosine A2b receptor	ADORA2B	0.0077
6043	Putative G-protein coupled receptor 44	GPR44	0.0077
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0076
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0076
484	Tyrosine-protein kinase ABL2	ABL2	0.0076
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0076
518	Peroxidase/catalase T	katG	0.0075
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0074
1541	Metalloproteinase	mmp20	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
856	Vitamin D3 receptor	VDR	0.0074
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0072
1275	Estrogen sulfotransferase	SULT1E1	0.0071
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0071
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0071
3809	Estrogen-related receptor gamma	ESRRG	0.0071
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
5300	Antigen peptide transporter 1	TAP1	0.0071
765	Indoleamine 2,3-dioxygenase	IDO1	0.0071
634	Squalene monooxygenase	SQLE	0.0071
7196	Squalene monooxygenase	ERG1	0.0071
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
6126	Carbonic anhydrase 7	CA7	0.007
131	Synaptic vesicular amine transporter	SLC18A2	0.007
581	Cytochrome P450 2R1	CYP2R1	0.007
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
976	Platelet glycoprotein IX	GP9	0.0067
6138	Multidrug resistance protein 3	ABCB4	0.0067
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0065
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0065
1820	Beta-nerve growth factor	NGF	0.0064
164	Histamine H4 receptor	HRH4	0.0064
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
1648	Elastin	ELN	0.0063
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0063
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
6044	Serum paraoxonase/lactonase 3	PON3	0.0062
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0062
319	Opioid receptor, sigma 1	OPRS1	0.0062
2981	Phospholipase A2, membrane associated	PLA2G2A	0.006
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.006
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0059
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0059
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
1992	Vitamin D-binding protein	GC	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0055
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0055
6149	Solute carrier family 22 member 10	SLC22A10	0.0055
6506	Stathmin-4	STMN4	0.0055
54	Prothrombin	F2	0.0054
558	Solute carrier family 12 member 1	SLC12A1	0.0054
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0054
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0053
1650	Heme carrier protein 1	SLC46A1	0.0053
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
712	Tubulin alpha chain	TUB1	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
174	Sigma 1-type opioid receptor	SIGMAR1	0.0052
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0052
4217	Telomerase reverse transcriptase	TERT	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0051
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0051
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0051
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0051
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0051
6824	Tyrosine-protein kinase Lyn	LYN	0.0051
1039	Histone deacetylase 9	HDAC9	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.005
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.005
563	Thyroid peroxidase	TPO	0.0048
714	Glutathione reductase, mitochondrial	GSR	0.0048
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0048
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
1374	Natriuretic peptides B	NPPB	0.0048
1827	Gap junction alpha-1 protein	GJA1	0.0048
1908	Vascular cell adhesion protein 1	VCAM1	0.0048
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0046
6167	Organic solute transporter subunit beta	OSTB	0.0045
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0045
6166	Organic solute transporter subunit alpha	OSTA	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0045
3086	Plasmepsin-2	Not Available	0.0045
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0045
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0045
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0045
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0045
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0045
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0045
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0044
153	Dopamine beta-hydroxylase	DBH	0.0044
1196	Complement decay-accelerating factor	CD55	0.0044
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
2599	Tyrosine-protein kinase HCK	HCK	0.0044
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0044
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0044
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0044
1483	Membrane copper amine oxidase	AOC3	0.0043
2216	Fibroblast growth factor receptor 4	FGFR4	0.0043
705	Glutamate receptor 1	GRIA1	0.0043
3639	Thymidine phosphorylase	deoA	0.0043
3936	Thymidine phosphorylase	TYMP	0.0043
291	Nitric-oxide synthase, endothelial	NOS3	0.0042
1864	RET proto-oncogene	RET	0.0042
1630	Integrin beta-2	ITGB2	0.0042
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0042
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0042
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
6168	Solute carrier family 22 member 16	SLC22A16	0.0042
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0042
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
5798	Mitogen-activated protein kinase 11	MAPK11	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2320	Thymidine kinase, cytosolic	TK1	0.004
730	Retinoic acid receptor alpha	RARA	0.004
4226	Uridine phosphorylase 2	UPP2	0.004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.004
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
2808	Chloramphenicol acetyltransferase 3	cat3	0.0038
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0038
751	Potassium channel subfamily K member 6	KCNK6	0.0038
1760	Aminopeptidase N	ANPEP	0.0038
6843	Aminopeptidase N	pepN	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
4225	Uridine phosphorylase 1	UPP1	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
760	Fibroblast growth factor 1	FGF1	0.0036
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0036
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
489	Monocarboxylate transporter 2	SLC16A7	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0035
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
2417	Chloramphenicol acetyltransferase	cat	0.0035
3278	Chloramphenicol acetyltransferase	cat	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
6837	Serine/threonine-protein kinase 17B	STK17B	0.0035
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0035
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
172	Potassium channel subfamily K member 1	KCNK1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
293	Gamma-glutamyl hydrolase	GGH	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0034
413	Amidophosphoribosyltransferase	PPAT	0.0034
2515	Amidophosphoribosyltransferase	purF	0.0034
3714	Amidophosphoribosyltransferase	purF	0.0034
758	Thyroid hormone receptor alpha	THRA	0.0034
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0034
267	Plasminogen activator inhibitor 1	SERPINE1	0.0034
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0034
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
5626	Nucleoside diphosphate kinase B	NME2	0.0033
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
76	Nitric-oxide synthase, brain	NOS1	0.0032
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
572	Integrin alpha-L	ITGAL	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6221	Steroid hormone receptor ERR1	ESRRA	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.003
6228	Nuclear receptor coactivator 1	NCOA1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
702	UMP-CMP kinase	CMPK1	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0029
6048	Troponin C, skeletal muscle	TNNC2	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
1291	cAMP response element-binding protein	CREB1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
822	Aldose reductase	AKR1B1	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
473	L-lactate dehydrogenase A chain	LDHA	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
5294	Nucleoside diphosphate kinase A	NME1	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
6131	Carbonic anhydrase 14	CA14	0.0026
6859	Protein S100-A4	S100A4	0.0025
2021	Thrombomodulin	THBD	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
3913	Glutamic acid decarboxylase	GAD65	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0025
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6122	Carbonic anhydrase 3	CA3	0.0024
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0024
6218	Pannexin-1	PANX1	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
3904	Alanine aminotransferase 2	GPT2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
2207	Rhodopsin	RHO	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
627	11-cis retinol dehydrogenase	RDH5	0.002
422	Vitamin K-dependent protein C	PROC	0.002
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
3587	Gastrotropin	FABP6	0.0017
1792	Tissue-type plasminogen activator	PLAT	0.0017
3221	Cytochrome c4	cc4	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6151	Monocarboxylate transporter 10	SLC16A10	0.0017
4948	Cytochrome c-553	Not Available	0.0017
4923	Cytochrome c3	DvMF_2499	0.0017
4945	Cytochrome c3	Not Available	0.0017
4949	Cytochrome c3	DVU_3171	0.0017
4968	Cytochrome c3	cytc3	0.0017
4997	Cytochrome c3	SO_2727	0.0017
5219	Cytochrome c3	cyd	0.0017
4902	Nine-heme cytochrome c	Ddes_2038	0.0017
3189	High-molecular-weight cytochrome c	hmcA	0.0017
798	Osteocalcin	BGLAP	0.0016
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
3007	Carbonic anhydrase 12	CA12	0.0016
4205	Carbonic anhydrase 9	CA9	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
369	Coagulation factor VII	F7	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
4954	Soluble cytochrome b558	Not Available	0.0014
4934	Cytochrome c-551	nirM	0.0014
5218	Cytochrome c-551	nirM	0.0014
4905	Cytochrome c2	Not Available	0.0014
4939	Cytochrome c2	cycA	0.0014
4964	Cytochrome c2	cycA	0.0014
4979	Cytochrome c2	cycA	0.0014
6673	Cytochrome c2	cycA	0.0014
4915	Cytochrome c-550	psbV	0.0014
4959	Cytochrome c-550	psbV	0.0014
5216	Cytochrome c-550	psbV	0.0014
4925	Cytochrome c-type protein SHP	shp	0.0014
4947	Bacterial hemoglobin	vhb	0.0014
4998	Hemoglobin-like protein yjbI	yjbI	0.0014
4975	Cytochrome c-556	RPA3973	0.0014
4943	Cytochrome c6	petJ	0.0014
4916	Cyanoglobin	glbN	0.0014
4984	Neuroglobin	NGB	0.0014
4936	Cytochrome c2 iso-2	Not Available	0.0014
4994	Hemoglobin-like protein HbO	glbO	0.0014
4907	Cytochrome c-L	moxG	0.0014
6865	Cytochrome c-L	moxG	0.0014
4909	CooA protein	cooA	0.0014
4942	Diheme cytochrome c napB	napB	0.0014
4935	Cytochrome c-554	cycA1	0.0014
4904	Cytochrome c family protein	GSU1996	0.0014
4910	Cytoglobin	CYGB	0.0014
4961	Hemophore HasA	hasA	0.0014
4971	Nonaheme cytochrome c	hmcA	0.0014
4981	Iron-starvation protein PigA	pigA	0.0014
5000	HemO	hemO	0.0014
4989	Cytochrome c551 peroxidase	ccp	0.0014
5222	Cytochrome c551 peroxidase	ccpA	0.0014
4976	Apocytochrome f	petA	0.0014
6407	Apocytochrome f	petA	0.0014
4999	Cytochrome P450 165B3	CYP165B3	0.0014
4764	Cytochrome P450 165C4	CYP165C4	0.0014
4960	Putative cytochrome P450-family protein	SCO7417	0.0014
4931	Cytochrome P450 167A1	CYP167A1	0.0014
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0014
4937	Cytochrome oxidase subunit II	rcoxA	0.0014
4993	Hydroxylamine oxidoreductase	hao1	0.0014
4903	Methyl-accepting chemotaxis protein	Tar4	0.0014
4922	Cytochrome c, putative	SO_4144	0.0014
4972	P450cin	cinA	0.0014
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0014
3093	Catalase HPII	katE	0.0014
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0014
4952	Catalase/peroxidase	katA	0.0014
4386	Hemoglobin-like protein HbN	glbN	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
810	Heme oxygenase 1	HMOX1	0.0013
3391	Heme oxygenase 1	pbsA1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
2298	Cytochrome P450-cam	camC	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
816	Biliverdin reductase A	BLVRA	0.0011
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0011
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0011
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1507	Cytochrome c	CYCS	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
4920	Peroxidase/catalase	katG	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0011
2119	Cytochrome b5	CYB5A	0.0011
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0011
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0011
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0011
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0011
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0011
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0011
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0011
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0011
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0011
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0011
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0011
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0011
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0011
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0011
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0011
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0011
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0011
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0011
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0011
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0011
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0011
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0011
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0011
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0011
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0011
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0011
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0011
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.001
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.001
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.001
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.001
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.001
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.001
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.001
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.001
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.001
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.001
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.001
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.001
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.001
644	Heme oxygenase 2	HMOX2	0.001
4982	Heme oxygenase 2	pbsA2	0.001
729	GDP-L-fucose synthetase	TSTA3	0.001
3463	GDP-L-fucose synthetase	fcl	0.001
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.001
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.001
167	L-lactate dehydrogenase C chain	LDHC	0.001
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.001
206	3-keto-steroid reductase	HSD17B7	0.001
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.001
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.001
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.001
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.001
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.001
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.001
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.001
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.001
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.001
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.001
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.001
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.001
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.001
34	7-dehydrocholesterol reductase	DHCR7	0.001
711	UDP-glucose 6-dehydrogenase	UGDH	0.001
3672	UDP-glucose 6-dehydrogenase	hasB	0.001
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.001
107	C-4 methylsterol oxidase	SC4MOL	0.001
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.001
3726	D-3-phosphoglycerate dehydrogenase	serA	0.001
4291	D-3-phosphoglycerate dehydrogenase	serA	0.001
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.001
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.001
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.001
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.001
643	Peroxisomal bifunctional enzyme	EHHADH	0.001
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.001
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.001
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.001
4990	PpcA	ppcA	0.001
4988	Sulfite oxidase, mitochondrial	SUOX	0.001
3375	Acidic cytochrome c3	Not Available	0.001
4385	Cytochrome c'	Not Available	0.001
4967	Cytochrome c'	cycA	0.001
5038	Cytochrome c'	Not Available	0.001
5223	Cytochrome c'	cycP	0.001
2915	Sensor protein fixL	fixL	0.001
4944	Sensor protein fixL	fixL	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
3570	Cytochrome P450 152A1	cypC	0.001
4992	Cytochrome c peroxidase	Not Available	0.001
4813	Heme oxygenase	hmuO	0.001
5769	Heme oxygenase	Not Available	0.001
4289	Cytochrome P450	TT_P0059	0.001
6262	Cytochrome P450	staP	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2230	Catalase	CAT	0.001
3249	Catalase	katA	0.001
3625	Catalase	katA	0.001
4539	Catalase	katA	0.001
4941	Catalase	katB	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.001
646	Malate dehydrogenase, cytoplasmic	MDH1	0.001
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.001
328	Sorbitol dehydrogenase	SORD	0.001
396	Alcohol dehydrogenase 4	ADH4	0.001
597	Dihydropteridine reductase	QDPR	0.001
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.001
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3670	Soluble cytochrome b562 precursor	cybC	0.0009
3411	Cytochrome P450 121	cyp121	0.0009
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0009
666	NADP-dependent malic enzyme	ME1	0.0009
3291	Cytochrome c-552	cycA	0.0009
4927	Cytochrome c-552	nrfA	0.0009
4938	Cytochrome c-552	cycA	0.0009
4953	Cytochrome c-552	nrfA	0.0009
5217	Cytochrome c-552	cycM	0.0009
2617	Nitric oxide synthase oxygenase	nos	0.0009
2701	Nitric oxide synthase oxygenase	nos	0.0009
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6026	Alcohol dehydrogenase 6	ADH6	0.0009
3102	Flavohemoprotein	hmp	0.0009
4969	Flavohemoprotein	hmp	0.0009
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0009
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0009
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0009
857	Malate dehydrogenase, mitochondrial	MDH2	0.0009
626	Cysteine dioxygenase type 1	CDO1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0009
12	Alcohol dehydrogenase class 3	ADH5	0.0009
77	L-lactate dehydrogenase B chain	LDHB	0.0009
2132	Protein S100-B	S100B	0.0009
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0008
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0008
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0008
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0008
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0008
13	Aminomethyltransferase, mitochondrial	AMT	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0008
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0008
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0008
1867	Major prion protein	PRNP	0.0008
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
279	Tyrosinase	TYR	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0008
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
4608	Putative cytochrome P450	SCO1207	0.0008
4963	Putative cytochrome P450	SCO2884	0.0008
6254	Putative cytochrome P450	SCO6998	0.0008
1025	Aquaporin-1	AQP1	0.0008
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
358	Cystathionine beta-synthase	CBS	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
654	Flavin reductase	BLVRB	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
693	Hemoglobin subunit beta	HBB	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
6268	Hydroxyacid oxidase 1	HAO1	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00448 - Lansoprazole

Targets

Enzymes

Transporters

Predictions