DT-Web: DB00776

Identification

Name

Oxcarbazepine

Accession Number

DB00776 (APRD01308)

Type

small molecule

Description

Oxcarbazepine is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat partial seizures in epileptic children and adults.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Anticonvulsants

Molecular Weight

252.268

Groups

approved

Monoisotopic Weight

252.089877638

Pharmacology

Indication

For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.

Mechanism of action

The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily through its 10-monohydroxy metabolite (MHD). In vitro studies indicate an MHD-induced blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neuronal membranes, inhibition of repetitive neuronal discharges, and diminution of propagation of synaptic impulses.

Absorption

Completely absorbed following oral administration. Food has no effect on the rate and extent of absorption of oxcarbazepine. After single-dose administration of Trileptal tablets to healthy male volunteers under fasted conditions, the median tmax was 4.5 (range 3 to 13) hours. After single-dose administration of Trileptal oral suspension to healthy male volunteers under fasted conditions, the median tmax was six hours. Steady-state plasma concentrations of MHD are reached within 2-3 days in patients when Trileptal is given twice a day.

Protein binding

Approximately 40% of the active 10-monohydroxy metabolite (MHD) is bound to serum proteins, predominantly to albumin. Neither oxcarbazepine nor its MHD binds with alpha-1-acid glycoprotein.

Biotransformation

Oxcarbazepine is completely absorbed and extensively metabolized to its pharmacologically active 10-monohydroxy metabolite (MHD) by cytosolic enzymes. MHD is metabolized further by conjugation with glucuronic acid.

Route of elimination

Oxcarbazepine is cleared from the body mostly in the form of metabolites which are predominantly excreted by the kidneys. Fecal excretion accounts for less than 4% of the administered dose.

Toxicity

Isolated cases of overdose with oxcarbazepine have been reported. The maximum dose taken was approximately 24,000 mg. All patients recovered with symptomatic treatment.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Cyclosporine	Oxcarbazepine decreases the effect of cyclosporine
Ethinyl Estradiol	Oxcarbazepine may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be solely relied upon during concomitant therapy with oxcarbazepine.
Ethotoin	Oxcarbazepine increases the effect of hydantoin
Felodipine	Oxcarbazepine decreases the levels of felodipine
Fosphenytoin	Oxcarbazepine increases the effect of hydantoin
Mephenytoin	Oxcarbazepine increases the effect of hydantoin
Mestranol	Oxcarbazepine decreases the effect of the contraceptive
Phenytoin	Oxcarbazepine increases the effect of hydantoin
Rilpivirine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Roflumilast	Affects CYP3A4 metabolism, decreases level or effect of roflumilast.
Telithromycin	Oxcarbazepine may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus	Oxcarbamazepine may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Tramadol	Oxcarbazepine may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone	The CYP3A4 inducer, Oxcarbazepine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Oxcarbazepine is initiated, discontinued or dose changed.
Ulipristal	Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.

Food Interactions

Take without regard to meals. Avoid alcohol.

Sodium channel protein type 5 subunit alpha
Name	Sodium channel protein type 5 subunit alpha
Gene Name	SCN5A
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Vohora D, Saraogi P, Yazdani MA, Bhowmik M, Khanam R, Pillai KK: Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs. Drugs Today (Barc). 2010 Apr;46(4):265-77. - Pubmed
DTHybrid score	0.4731

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2968
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4767
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2575

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.2219
4757	Cytochrome P450 2C9	CYP2C9	0.2194
1588	Multidrug resistance protein 1	ABCB1	0.1712
4200	Cytochrome P450 1A2	CYP1A2	0.1659
6107	Cytochrome P450 3A7	CYP3A7	0.1531
4924	Cytochrome P450 2C8	CYP2C8	0.1516
6030	Cytochrome P450 2B6	CYP2B6	0.1128
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0811
6013	Cytochrome P450 2E1	CYP2E1	0.0808
6024	Cytochrome P450 1A1	CYP1A1	0.0613
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0603
20	Prostaglandin G/H synthase 1	PTGS1	0.0536
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0479
5718	Cytochrome P450 2A6	CYP2A6	0.0476
1729	Solute carrier family 22 member 6	SLC22A6	0.0439
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0428
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0412
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0404
6106	Cytochrome P450 2C18	CYP2C18	0.0396
6145	Solute carrier family 22 member 1	SLC22A1	0.0378
862	Multidrug resistance-associated protein 1	ABCC1	0.0334
290	Prostaglandin G/H synthase 2	PTGS2	0.0326
6144	Solute carrier family 22 member 2	SLC22A2	0.0314
824	Sodium-dependent serotonin transporter	SLC6A4	0.031
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0296
492	Histamine H1 receptor	HRH1	0.0295
6142	Solute carrier family 22 member 8	SLC22A8	0.0285
465	Calmodulin	CALM1	0.0278
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0275
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0268
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0259
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0255
3811	Cytochrome P450 19A1	CYP19A1	0.0254
871	Glucocorticoid receptor	NR3C1	0.0251
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0246
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.024
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0237
891	Dihydropteroate synthase	folP	0.0236
5359	Dihydropteroate synthase	folP	0.0236
7175	Dihydropteroate synthase	sulI	0.0236
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0232
831	D(2) dopamine receptor	DRD2	0.023
556	Alpha-1A adrenergic receptor	ADRA1A	0.0227
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0225
118	Organic cation/carnitine transporter 2	SLC22A5	0.0224
776	Bile salt export pump	ABCB11	0.0217
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0216
1898	Cytochrome P450 1B1	CYP1B1	0.0215
6143	Solute carrier family 22 member 7	SLC22A7	0.0213
3923	Cholinesterase	BCHE	0.0211
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0208
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0207
731	HIV-1 protease	HIV-1 protease	0.0205
847	Mu-type opioid receptor	OPRM1	0.0203
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0195
6031	Cytochrome P450 3A43	CYP3A43	0.0194
260	Cytochrome P450 51	ERG11	0.0193
761	Cytochrome P450 51	ERG11	0.0193
3163	Cytochrome P450 51	cyp51	0.0193
2164	Multidrug resistance-associated protein 4	ABCC4	0.0192
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0189
23	D(1A) dopamine receptor	DRD1	0.0186
632	Alpha-1B adrenergic receptor	ADRA1B	0.0179
1024	Solute carrier family 22 member 11	SLC22A11	0.0177
136	Estrogen receptor	ESR1	0.0175
1389	Transforming growth factor beta-1	TGFB1	0.0169
713	Sodium-dependent dopamine transporter	SLC6A3	0.0168
844	Epidermal growth factor receptor	EGFR	0.0165
6220	Aryl hydrocarbon receptor	AHR	0.0159
318	Alpha-2A adrenergic receptor	ADRA2A	0.0156
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0156
467	Delta-type opioid receptor	OPRD1	0.0153
172	Potassium channel subfamily K member 1	KCNK1	0.015
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.015
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.015
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0148
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0147
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0144
833	Organic cation/carnitine transporter 1	SLC22A4	0.0143
696	Kappa-type opioid receptor	OPRK1	0.0143
6147	Solute carrier family 22 member 3	SLC22A3	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0139
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0139
756	Sex hormone-binding globulin	SHBG	0.0138
33	Cystine/glutamate transporter	SLC7A11	0.0136
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0135
614	Progesterone receptor	PGR	0.0134
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0133
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0133
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0133
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0133
6182	Cytochrome P450 2J2	CYP2J2	0.0132
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0132
146	Androgen receptor	AR	0.0132
766	Beta-2 adrenergic receptor	ADRB2	0.0131
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0131
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.013
705	Glutamate receptor 1	GRIA1	0.0128
232	Corticosteroid-binding globulin	SERPINA6	0.0127
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0127
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0127
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0126
468	Cytochrome P450 4A11	CYP4A11	0.0125
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0123
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0122
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0122
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.012
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0119
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0118
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0115
638	D(3) dopamine receptor	DRD3	0.0115
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0115
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0115
122	P2Y purinoceptor 12	P2RY12	0.0113
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0112
817	DNA topoisomerase 2-alpha	TOP2A	0.0111
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0111
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0111
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.011
6148	Multidrug resistance-associated protein 7	ABCC10	0.011
921	Glutamate receptor 2	GRIA2	0.0108
789	Alpha-1D adrenergic receptor	ADRA1D	0.0106
3941	Amine oxidase [flavin-containing] A	MAOA	0.0105
4604	Liver carboxylesterase 1	CES1	0.0104
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0103
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0103
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0103
811	Translocator protein	TSPO	0.0102
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0099
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0099
2211	Fatty acid-binding protein, heart	FABP3	0.0098
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0095
629	Alpha-2B adrenergic receptor	ADRA2B	0.0095
566	Serotransferrin	TF	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0094
378	Alpha-2C adrenergic receptor	ADRA2C	0.0093
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.009
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0089
193	Beta-1 adrenergic receptor	ADRB1	0.0088
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0088
70	Type-1 angiotensin II receptor	AGTR1	0.0088
818	50S ribosomal protein L10	rplJ	0.0087
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0087
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0086
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0086
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0086
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0086
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0086
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0086
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0086
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0085
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0084
6141	Sodium/bile acid cotransporter	SLC10A1	0.0084
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0084
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0084
373	Transthyretin	TTR	0.0084
183	Vascular endothelial growth factor A	VEGFA	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
737	Mineralocorticoid receptor	NR3C2	0.0083
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0083
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0082
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0081
3939	Amine oxidase [flavin-containing] B	MAOB	0.0081
6137	Multidrug resistance-associated protein 6	ABCC6	0.008
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.008
482	Glycine receptor subunit alpha-1	GLRA1	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0077
777	Tumor necrosis factor	TNF	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
432	D(4) dopamine receptor	DRD4	0.0077
124	Histamine H2 receptor	HRH2	0.0075
1656	CYP2B protein	CYP2B	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
504	Mast/stem cell growth factor receptor	KIT	0.0072
6020	Aldehyde oxidase	AOX1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0071
26	Vascular endothelial growth factor receptor 3	FLT4	0.0071
407	Vascular endothelial growth factor receptor 2	KDR	0.0071
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.007
768	FK506-binding protein 1A	FKBP1A	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0069
738	Monocarboxylate transporter 1	SLC16A1	0.0069
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0069
6136	Multidrug resistance-associated protein 5	ABCC5	0.0068
592	Carbonic anhydrase 4	CA4	0.0068
29	Tubulin beta-1 chain	TUBB1	0.0068
2539	Tubulin alpha-1 chain	TUBA4A	0.0068
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0068
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0068
32	Vascular endothelial growth factor receptor 1	FLT1	0.0068
6085	Fatty acid-binding protein, intestinal	FABP2	0.0067
6102	Arylamine N-acetyltransferase 2	NAT2	0.0066
36	Insulin receptor	INSR	0.0066
716	5-hydroxytryptamine 7 receptor	HTR7	0.0065
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0065
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0065
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0064
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0064
161	Tubulin beta chain	TUBB	0.0064
312	Tubulin beta chain	TUB2	0.0064
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
3932	Glutathione S-transferase A2	GSTA2	0.0062
380	Cytochrome P450 17A1	CYP17A1	0.0062
952	Dipeptidyl peptidase 4	DPP4	0.0062
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0061
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.006
357	Carbonic anhydrase 2	CA2	0.006
6043	Putative G-protein coupled receptor 44	GPR44	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0059
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0059
558	Solute carrier family 12 member 1	SLC12A1	0.0058
723	Cytosolic phospholipase A2	PLA2G4A	0.0058
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0056
5300	Antigen peptide transporter 1	TAP1	0.0056
869	Estrogen receptor beta	ESR2	0.0055
295	Carbonic anhydrase 1	CA1	0.0054
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0054
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0054
427	Substance-P receptor	TACR1	0.0054
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0053
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0053
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0052
49	Endothelin B receptor	EDNRB	0.0052
1010	Cytochrome P450 51A1	CYP51A1	0.0052
6014	Cytochrome P450 2A13	CYP2A13	0.0051
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.005
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.005
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
4237	50S ribosomal protein L22	rplV	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0049
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0049
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0049
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
68	Cannabinoid receptor 1	CNR1	0.0048
239	Coagulation factor X	F10	0.0047
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0047
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0045
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
163	D(1B) dopamine receptor	DRD5	0.0044
571	Melatonin receptor type 1A	MTNR1A	0.0044
362	Melatonin receptor type 1B	MTNR1B	0.0044
1618	High affinity nerve growth factor receptor	NTRK1	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
4120	NADPH--cytochrome P450 reductase	POR	0.0043
1483	Membrane copper amine oxidase	AOC3	0.0043
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
477	DNA topoisomerase 4 subunit A	parC	0.0042
886	DNA topoisomerase 4 subunit A	parC	0.0042
6226	DNA topoisomerase 4 subunit A	parC	0.0042
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0042
814	Ryanodine receptor 1	RYR1	0.0042
856	Vitamin D3 receptor	VDR	0.0042
404	DNA gyrase subunit A	gyrA	0.0042
6224	DNA gyrase subunit A	gyrA	0.0042
1525	Heparin-binding growth factor 2	FGF2	0.0042
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0042
6126	Carbonic anhydrase 7	CA7	0.0042
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0041
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
5787	Angiopoietin-1 receptor	TEK	0.0041
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0041
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
823	Fibroblast growth factor receptor 2	FGFR2	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.004
459	Retinoic acid receptor RXR-alpha	RXRA	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
284	DNA-directed RNA polymerase beta chain	rpoB	0.0038
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0038
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0038
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0038
1050	Bile salt sulfotransferase	SULT2A1	0.0038
85	Growth hormone receptor	GHR	0.0038
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0037
3426	Glutamine synthetase	glnA	0.0037
3987	Glutamine synthetase	GLUL	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0037
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0037
94	5-hydroxytryptamine 4 receptor	HTR4	0.0037
6432	Transporter	snf	0.0037
165	FL cytokine receptor	FLT3	0.0037
4311	tRNA	TRDMT1	0.0036
4325	tRNA	trmD	0.0036
4328	tRNA	trmD	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0036
54	Prothrombin	F2	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
6174	50S ribosomal protein L32	rpmF	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1196	Complement decay-accelerating factor	CD55	0.0034
275	Arachidonate 5-lipoxygenase	ALOX5	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0034
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0034
4238	50S ribosomal protein L4	rplD	0.0033
5578	50S ribosomal protein L4	rplD	0.0033
6173	50S ribosomal protein L4	rplD	0.0033
6219	50S ribosomal protein L4	rplD	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
474	Acetylcholinesterase	ACHE	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
5934	Cytochrome P450 26A1	CYP26A1	0.0033
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0033
904	Glutathione S-transferase P	GSTP1	0.0033
273	Apoptosis regulator Bcl-2	BCL2	0.0033
1992	Vitamin D-binding protein	GC	0.0033
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0033
88	Retinoic acid receptor RXR-beta	RXRB	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0032
1852	Microtubule-associated protein 2	MAP2	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
6677	Myelin P2 protein	PMP2	0.0032
6131	Carbonic anhydrase 14	CA14	0.0032
1867	Major prion protein	PRNP	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
3086	Plasmepsin-2	Not Available	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1757	Myeloperoxidase	MPO	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
3947	Xanthine dehydrogenase/oxidase	XDH	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6134	Sodium channel subunit beta-3	SCN3B	0.0031
6135	Sodium channel subunit beta-4	SCN4B	0.003
6132	Sodium channel subunit beta-1	SCN1B	0.003
6133	Sodium channel subunit beta-2	SCN2B	0.003
6127	Carbonic anhydrase-related protein	CA8	0.003
6129	Carbonic anhydrase-related protein 11	CA11	0.003
6128	Carbonic anhydrase-related protein 10	CA10	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.003
751	Potassium channel subfamily K member 6	KCNK6	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.003
6122	Carbonic anhydrase 3	CA3	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
2808	Chloramphenicol acetyltransferase 3	cat3	0.003
6149	Solute carrier family 22 member 10	SLC22A10	0.003
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
469	Annexin A1	ANXA1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0028
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0028
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0028
3601	Dihydropteroate synthase 1	folP1	0.0027
3807	Dihydropteroate synthase 1	folP1	0.0027
3808	Dihydropteroate synthase 2	folP2	0.0027
2417	Chloramphenicol acetyltransferase	cat	0.0027
3278	Chloramphenicol acetyltransferase	cat	0.0027
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0027
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0027
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2810	Dr hemagglutinin structural subunit	draA	0.0027
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0027
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0027
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0027
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
4210	Toll-like receptor 4	TLR4	0.0026
4122	Histone deacetylase 2	HDAC2	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6130	Carbonic anhydrase 13	CA13	0.0026
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
4203	Histamine N-methyltransferase	HNMT	0.0026
1864	RET proto-oncogene	RET	0.0026
3913	Glutamic acid decarboxylase	GAD65	0.0026
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0026
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0026
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0026
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
365	Dihydrofolate reductase	DHFR	0.0025
2381	Dihydrofolate reductase	DFR1	0.0025
2833	Dihydrofolate reductase	Not Available	0.0025
2931	Dihydrofolate reductase	folA	0.0025
3544	Dihydrofolate reductase	folA	0.0025
3682	Dihydrofolate reductase	folA	0.0025
6642	Dihydrofolate reductase	folA	0.0025
6756	Dihydrofolate reductase	dfrA	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0025
2112	Toll-like receptor 9	TLR9	0.0025
5924	Microtubule-associated protein 4	MAP4	0.0024
5923	Microtubule-associated protein tau	MAPT	0.0024
581	Cytochrome P450 2R1	CYP2R1	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
84	Nuclear receptor 0B1	NR0B1	0.0024
4217	Telomerase reverse transcriptase	TERT	0.0024
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
162	Retinoic acid receptor gamma-1	RARG	0.0023
131	Synaptic vesicular amine transporter	SLC18A2	0.0023
1630	Integrin beta-2	ITGB2	0.0023
976	Platelet glycoprotein IX	GP9	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0023
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
518	Peroxidase/catalase T	katG	0.0022
3007	Carbonic anhydrase 12	CA12	0.0022
4205	Carbonic anhydrase 9	CA9	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
3904	Alanine aminotransferase 2	GPT2	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0021
707	72 kDa type IV collagenase	MMP2	0.0021
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0021
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
244	Angiotensin-converting enzyme	ACE	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
4773	Deoxycytidine kinase	DCK	0.0021
4192	DNA topoisomerase 2-beta	TOP2B	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
16	Adenosine A1 receptor	ADORA1	0.002
174	Sigma 1-type opioid receptor	SIGMAR1	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.002
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
106	Cannabinoid receptor 2	CNR2	0.002
3937	Fatty-acid amide hydrolase	FAAH	0.0019
1178	Adenosine A2a receptor	ADORA2A	0.0019
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0019
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0019
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0019
936	Ephrin type-A receptor 2	EPHA2	0.0019
2320	Thymidine kinase, cytosolic	TK1	0.0019
6044	Serum paraoxonase/lactonase 3	PON3	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
1253	Interferon gamma	IFNG	0.0018
1650	Heme carrier protein 1	SLC46A1	0.0018
563	Thyroid peroxidase	TPO	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
24	Thymidylate synthase	TMP1	0.0018
359	Thymidylate synthase	TYMS	0.0018
2626	Thymidylate synthase	thyA	0.0018
2729	Thymidylate synthase	thyA	0.0018
5352	Thymidylate synthase	THYA	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
2207	Rhodopsin	RHO	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0017
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
572	Integrin alpha-L	ITGAL	0.0017
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0017
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0017
634	Squalene monooxygenase	SQLE	0.0017
7196	Squalene monooxygenase	ERG1	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0017
267	Plasminogen activator inhibitor 1	SERPINE1	0.0017
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0017
2021	Thrombomodulin	THBD	0.0017
6218	Pannexin-1	PANX1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0016
3856	Fibroblast growth factor receptor 3	FGFR3	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
3809	Estrogen-related receptor gamma	ESRRG	0.0016
173	Toll-like receptor 7	TLR7	0.0016
1192	Sulfotransferase 1A1	SULT1A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
6221	Steroid hormone receptor ERR1	ESRRA	0.0015
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0015
7	Nitric oxide synthase, inducible	NOS2	0.0015
1039	Histone deacetylase 9	HDAC9	0.0015
1629	Transcription factor AP-1	JUN	0.0015
1541	Metalloproteinase	mmp20	0.0014
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0014
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
2216	Fibroblast growth factor receptor 4	FGFR4	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0013
6151	Monocarboxylate transporter 10	SLC16A10	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0013
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0013
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0013
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0013
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0013
6459	Glycodelin	PAEP	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4103	Proteasome subunit beta type 2	PSMB2	0.0012
4102	Proteasome subunit beta type 5	PSMB5	0.0012
4101	Proteasome subunit beta type 1	PSMB1	0.0012
822	Aldose reductase	AKR1B1	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0012
6042	Prostaglandin reductase 2	PTGR2	0.0012
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0012
6146	High affinity copper uptake protein 1	SLC31A1	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0011
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0011
1268	Neuropeptide S receptor	NPSR1	0.0011
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0011
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
251	Alcohol dehydrogenase 1A	ADH1A	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0011
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0011
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0011
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0011
569	Retinal dehydrogenase 2	ALDH1A2	0.0011
489	Monocarboxylate transporter 2	SLC16A7	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
820	Glycine receptor subunit alpha-2	GLRA2	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
6073	Potassium channel subfamily K member 9	KCNK9	0.001
6072	Potassium channel subfamily K member 3	KCNK3	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
164	Histamine H4 receptor	HRH4	0.001
444	Alcohol dehydrogenase 1B	ADH1B	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
3810	Catechol O-methyltransferase	COMT	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5798	Mitogen-activated protein kinase 11	MAPK11	0.0009
908	Glutathione S-transferase theta-1	GSTT1	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
3830	Calreticulin	CALR	0.0009
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0009
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0009
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0009
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0009
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
2132	Protein S100-B	S100B	0.0009
517	Alcohol dehydrogenase 1C	ADH1C	0.0009
3404	Exotoxin A	eta	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
291	Nitric-oxide synthase, endothelial	NOS3	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
293	Gamma-glutamyl hydrolase	GGH	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
5961	Insulin	INS	0.0005
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
1374	Natriuretic peptides B	NPPB	0.0004
1827	Gap junction alpha-1 protein	GJA1	0.0004
1908	Vascular cell adhesion protein 1	VCAM1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
3116	Bacterioferritin	bfr	0.0004
4906	Bacterioferritin	bfr	0.0004
4965	Bacterioferritin	bfr	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0003
4920	Peroxidase/catalase	katG	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
1275	Estrogen sulfotransferase	SULT1E1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
3221	Cytochrome c4	cc4	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
3957	Adenosine deaminase	ADA	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00776 - Oxcarbazepine

Targets

Enzymes

Carriers

Predictions