DT-Web

DB01023 - Felodipine


Identification
Name Felodipine
Accession Number DB01023 (APRD00374)
Type small molecule
Description Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 384.254
Groups approved
Monoisotopic Weight 383.069113515
Pharmacology
Indication For the treatment of mild to moderate essential hypertension.
Mechanism of action Felodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through voltage-gated L-type calcium channels. It reversibly competes against nitrendipine and other DHP CCBs for DHP binding sites in vascular smooth muscle and cultured rabbit atrial cells. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of felodipine result in an overall decrease in blood pressure. Felodipine may be used to treat mild to moderate essential hypertension.
Absorption Is completely absorbed from the gastrointestinal tract; however, extensive first-pass metabolism through the portal circulation results in a low systemic availability of 15%. Bioavailability is unaffected by food.
Protein binding 99%, primarily to the albumin fraction.
Biotransformation Hepatic metabolism primarily via cytochrome P450 3A4. Six metabolites with no appreciable vasodilatory effects have been identified.
Route of elimination Although higher concentrations of the metabolites are present in the plasma due to decreased urinary excretion, these are inactive. Animal studies have demonstrated that felodipine crosses the blood-brain barrier and the placenta.
Toxicity Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly bradycardia. Oral rat LD50 is 1050 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amobarbital The barbiturate, amobarbital, decreases the effect of felodipine.
Aprobarbital The barbiturate, aprobarbital, decreases the effect of felodipine.
Butabarbital The barbiturate, butabarbital, decreases the effect of felodipine.
Butalbital The barbiturate, butalbital, decreases the effect of felodipine.
Butethal The barbiturate, butethal, decreases the effect of felodipine.
Carbamazepine Carbamazepine may increase the metabolism of felodipine. Monitor for changes in the therapeutic and adverse effects of felodipine if carbamazepine is initiated, discontinued or dose changed.
Dihydroquinidine barbiturate The barbiturate, dihydroquinidine barbiturate, decreases the effect of felodipine.
Erythromycin Erythromycin increases the effect of felodipine
Ethotoin The hydantoin decreases the effect of felodipine
Fosphenytoin The hydantoin decreases the effect of felodipine
Heptabarbital The barbiturate, heptabarbital, decreases the effect of felodipine.
Hexobarbital The barbiturate, hexobarbital, decreases the effect of felodipine.
Itraconazole Itraconazole may increase the therapeutic and adverse effects of felodipine.
Josamycin Erythromycin increases the effect of felodipine
Mephenytoin The hydantoin decreases the effect of felodipine
Methohexital The barbiturate, methohexital, decreases the effect of felodipine.
Methylphenobarbital The barbiturate, methylphenobarbital, decreases the effect of felodipine.
Nelfinavir Nelfinavir increases the effect and toxicity of felodipine
Oxcarbazepine Oxcarbazepine decreases the levels of felodipine
Pentobarbital The barbiturate, pentobarbital, decreases the effect of felodipine.
Phenobarbital The barbiturate, phenobarbital, decreases the effect of felodipine.
Phenytoin The hydantoin decreases the effect of felodipine
Primidone The barbiturate, primidone, decreases the effect of felodipine.
Quinidine barbiturate The barbiturate, quinidine barbiturate, decreases the effect of felodipine.
Quinupristin This combination presents an increased risk of toxicity
Secobarbital The barbiturate, secobarbital, decreases the effect of felodipine.
Tacrolimus Felodipine increases tacrolimus levels
Talbutal The barbiturate, talbutal, decreases the effect of felodipine.
Telithromycin Telithromycin may reduce clearance of Felodipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Felodipine if Telithromycin is initiated, discontinued or dose changed.
Thiopental The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Felodipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Felodipine if Thiopental is initiated, discontinued or dose changed.
Tipranavir Tipranavir, co-administered with Ritonavir, may alter the concentration of Felopidine. Monitor for efficacy and adverse/toxic effects of Felopidine.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Tretinoin The moderate CYP2C8 inhibitor, Felopidine, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Felopidine is initiated, discontinued to dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of felodipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of felodipine if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of nifedipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of nifedipine and may cause toxicity. Avoid grapefruit products while on this medication.

Targets


Voltage-dependent L-type calcium channel subunit alpha-1C
Name Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name CACNA1C
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. - Pubmed
  • Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
  • Zahradnikova A, Minarovic I, Zahradnik I: Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists. J Pharmacol Exp Ther. 2007 Aug;322(2):638-45. Epub 2007 May 2. - Pubmed
DTHybrid score 0.7937
Voltage-dependent calcium channel subunit alpha-2/delta-1
Name Voltage-dependent calcium channel subunit alpha-2/delta-1
Gene Name CACNA2D1
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. - Pubmed
  • Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
  • Zahradnikova A, Minarovic I, Zahradnik I: Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists. J Pharmacol Exp Ther. 2007 Aug;322(2):638-45. Epub 2007 May 2. - Pubmed
DTHybrid score 0.6915
Voltage-dependent L-type calcium channel subunit beta-2
Name Voltage-dependent L-type calcium channel subunit beta-2
Gene Name CACNB2
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. - Pubmed
  • Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
  • Zahradnikova A, Minarovic I, Zahradnik I: Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists. J Pharmacol Exp Ther. 2007 Aug;322(2):638-45. Epub 2007 May 2. - Pubmed
DTHybrid score 0.6314
Voltage-dependent L-type calcium channel subunit alpha-1D
Name Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name CACNA1D
Pharmacological action yes
Actions inhibitor
References
  • Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. Epub 2008 Nov 24. - Pubmed
DTHybrid score 0.6262
Voltage-dependent L-type calcium channel subunit alpha-1S
Name Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name CACNA1S
Pharmacological action yes
Actions inhibitor
References
  • Peterson BZ, Catterall WA: Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug;70(2):667-75. Epub 2006 May 4. - Pubmed
DTHybrid score 0.6381
Voltage-dependent T-type calcium channel subunit alpha-1H
Name Voltage-dependent T-type calcium channel subunit alpha-1H
Gene Name CACNA1H
Pharmacological action unknown
Actions inhibitor
References
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
  • Perez-Reyes E, Van Deusen AL, Vitko I: Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. Epub 2008 Oct 30. - Pubmed
DTHybrid score 0.5194
Voltage-dependent calcium channel subunit alpha-2/delta-2
Name Voltage-dependent calcium channel subunit alpha-2/delta-2
Gene Name CACNA2D2
Pharmacological action unknown
Actions inhibitor
References
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
  • Perez-Reyes E, Van Deusen AL, Vitko I: Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. Epub 2008 Oct 30. - Pubmed
DTHybrid score 0.5349
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions other
References
  • Bostrom SL, Westerlund C, Rochester S, Vogel HJ: Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins. Biochem Pharmacol. 1988 Oct 1;37(19):3723-8. - Pubmed
  • Johnson JD, Andrews CT, Khabbaza EJ, Mills JS: The interaction of felodipine with calcium-binding proteins. J Cardiovasc Pharmacol. 1987;10 Suppl 1:S53-9. - Pubmed
  • Lamers JM, Cysouw KJ, Verdouw PD: Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase. Biochem Pharmacol. 1985 Nov 1;34(21):3837-43. - Pubmed
  • Lamers JM, Verdouw PD, Mas-Oliva J: The effects of felodipine and bepridil on calcium-stimulated calmodulin binding and calcium pumping ATPase of cardiac sarcolemma before and after removal of endogenous calmodulin. Mol Cell Biochem. 1987 Dec;78(2):169-76. - Pubmed
  • Mills JS, Bailey BL, Johnson JD: Cooperativity among calmodulin's drug binding sites. Biochemistry. 1985 Aug 27;24(18):4897-902. - Pubmed
  • Walsh MP, Sutherland C, Scott-Woo GC: Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes. Biochem Pharmacol. 1988 Apr 15;37(8):1569-80. - Pubmed
DTHybrid score 0.7286
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Gene Name PDE1B
Pharmacological action unknown
Actions inhibitor
References
  • Lamers JM, Cysouw KJ, Verdouw PD: Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase. Biochem Pharmacol. 1985 Nov 1;34(21):3837-43. - Pubmed
  • Sharma RK, Wang JH, Wu Z: Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists. J Neurochem. 1997 Aug;69(2):845-50. - Pubmed
DTHybrid score Not Available
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Gene Name PDE1A
Pharmacological action unknown
Actions inhibitor
References
  • Lamers JM, Cysouw KJ, Verdouw PD: Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase. Biochem Pharmacol. 1985 Nov 1;34(21):3837-43. - Pubmed
  • Sharma RK, Wang JH, Wu Z: Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists. J Neurochem. 1997 Aug;69(2):845-50. - Pubmed
DTHybrid score Not Available
Mineralocorticoid receptor
Name Mineralocorticoid receptor
Gene Name NR3C2
Pharmacological action unknown
Actions antagonist
References
  • Dietz JD, Du S, Bolten CW, Payne MA, Xia C, Blinn JR, Funder JW, Hu X: A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity. Hypertension. 2008 Mar;51(3):742-8. Epub 2008 Feb 4. - Pubmed
DTHybrid score 0.5242
Troponin C, skeletal muscle
Name Troponin C, skeletal muscle
Gene Name TNNC2
Pharmacological action unknown
Actions other
References
  • Bostrom SL, Westerlund C, Rochester S, Vogel HJ: Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins. Biochem Pharmacol. 1988 Oct 1;37(19):3723-8. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9125
Troponin C, slow skeletal and cardiac muscles
Name Troponin C, slow skeletal and cardiac muscles
Gene Name TNNC1
Pharmacological action unknown
Actions other
References
  • Bostrom SL, Westerlund C, Rochester S, Vogel HJ: Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins. Biochem Pharmacol. 1988 Oct 1;37(19):3723-8. - Pubmed
DTHybrid score 0.7351

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • AstraZeneca LP. Plendil® (felodipine) extended-release tablets prescribing information. Wilmington, DE; 2003 Nov. -
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. - Pubmed
DTHybrid score 0.9684
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.6544
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.5336
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J Biol Chem. 2008 Jun 20;283(25):17227-37. Epub 2008 Apr 15. - Pubmed
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5076
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6167
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7074

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
DTHybrid score 0.703

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3943
6016 Cytochrome P450 2C19 CYP2C19 0.3803
6030 Cytochrome P450 2B6 CYP2B6 0.265
6013 Cytochrome P450 2E1 CYP2E1 0.2188
6024 Cytochrome P450 1A1 CYP1A1 0.1967
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.1877
5718 Cytochrome P450 2A6 CYP2A6 0.1777
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.1747
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.1685
1108 Calpastatin CAST 0.1666
1089 Cartilage oligomeric matrix protein COMP 0.1666
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.1338
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.1309
722 Troponin I, cardiac muscle TNNI3 0.1178
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.1136
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.1133
587 Serum albumin ALB 0.1108
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1108
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1088
556 Alpha-1A adrenergic receptor ADRA1A 0.1042
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.1037
492 Histamine H1 receptor HRH1 0.1019
2132 Protein S100-B S100B 0.1017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.1007
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.1005
831 D(2) dopamine receptor DRD2 0.0983
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0948
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0938
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0937
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0904
20 Prostaglandin G/H synthase 1 PTGS1 0.0874
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.087
871 Glucocorticoid receptor NR3C1 0.0866
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0801
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0799
1181 Alpha-1-acid glycoprotein 1 ORM1 0.079
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0767
862 Multidrug resistance-associated protein 1 ABCC1 0.0761
146 Androgen receptor AR 0.076
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0747
6106 Cytochrome P450 2C18 CYP2C18 0.0738
632 Alpha-1B adrenergic receptor ADRA1B 0.0712
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0709
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0703
824 Sodium-dependent serotonin transporter SLC6A4 0.0699
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0654
6145 Solute carrier family 22 member 1 SLC22A1 0.0648
614 Progesterone receptor PGR 0.0641
789 Alpha-1D adrenergic receptor ADRA1D 0.063
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0609
193 Beta-1 adrenergic receptor ADRB1 0.0602
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0595
3923 Cholinesterase BCHE 0.059
16 Adenosine A1 receptor ADORA1 0.0589
290 Prostaglandin G/H synthase 2 PTGS2 0.0584
4604 Liver carboxylesterase 1 CES1 0.0581
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0579
847 Mu-type opioid receptor OPRM1 0.0575
4246 Voltage-dependent anion-selective channel protein 2 VDAC2 0.0564
4247 Voltage-dependent anion-selective channel protein 3 VDAC3 0.0564
4245 Voltage-dependent anion-selective channel protein 1 VDAC1 0.0563
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0551
6220 Aryl hydrocarbon receptor AHR 0.055
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0547
502 5-hydroxytryptamine 2A receptor HTR2A 0.0546
776 Bile salt export pump ABCB11 0.0539
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0528
1898 Cytochrome P450 1B1 CYP1B1 0.051
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0497
318 Alpha-2A adrenergic receptor ADRA2A 0.0485
6144 Solute carrier family 22 member 2 SLC22A2 0.0483
1729 Solute carrier family 22 member 6 SLC22A6 0.048
118 Organic cation/carnitine transporter 2 SLC22A5 0.048
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0468
3811 Cytochrome P450 19A1 CYP19A1 0.045
467 Delta-type opioid receptor OPRD1 0.0448
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0441
766 Beta-2 adrenergic receptor ADRB2 0.044
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0437
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0417
696 Kappa-type opioid receptor OPRK1 0.0417
320 5-hydroxytryptamine 1A receptor HTR1A 0.0411
23 D(1A) dopamine receptor DRD1 0.0405
136 Estrogen receptor ESR1 0.0394
6031 Cytochrome P450 3A43 CYP3A43 0.0392
380 Cytochrome P450 17A1 CYP17A1 0.0391
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.039
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0376
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0374
2164 Multidrug resistance-associated protein 4 ABCC4 0.0372
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0366
1507 Cytochrome c CYCS 0.0362
629 Alpha-2B adrenergic receptor ADRA2B 0.0357
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0356
378 Alpha-2C adrenergic receptor ADRA2C 0.0349
731 HIV-1 protease HIV-1 protease 0.0345
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0343
6859 Protein S100-A4 S100A4 0.0339
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0337
6228 Nuclear receptor coactivator 1 NCOA1 0.0331
713 Sodium-dependent dopamine transporter SLC6A3 0.0327
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0326
590 5-hydroxytryptamine 2C receptor HTR2C 0.0317
6143 Solute carrier family 22 member 7 SLC22A7 0.0316
638 D(3) dopamine receptor DRD3 0.0316
6147 Solute carrier family 22 member 3 SLC22A3 0.0315
6142 Solute carrier family 22 member 8 SLC22A8 0.0313
232 Corticosteroid-binding globulin SERPINA6 0.0301
295 Carbonic anhydrase 1 CA1 0.0299
6182 Cytochrome P450 2J2 CYP2J2 0.0292
341 5-hydroxytryptamine 3 receptor HTR3A 0.0291
6148 Multidrug resistance-associated protein 7 ABCC10 0.0291
198 Sodium channel protein type 10 subunit alpha SCN10A 0.028
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0279
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0275
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0274
833 Organic cation/carnitine transporter 1 SLC22A4 0.0272
260 Cytochrome P450 51 ERG11 0.0263
761 Cytochrome P450 51 ERG11 0.0263
3163 Cytochrome P450 51 cyp51 0.0263
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0262
5694 Transcription antiterminator licT licT 0.0262
3361 Serpin B5 SERPINB5 0.0262
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0261
751 Potassium channel subfamily K member 6 KCNK6 0.0261
3941 Amine oxidase [flavin-containing] A MAOA 0.0243
233 Potassium channel subfamily K member 2 KCNK2 0.0242
3947 Xanthine dehydrogenase/oxidase XDH 0.024
817 DNA topoisomerase 2-alpha TOP2A 0.024
172 Potassium channel subfamily K member 1 KCNK1 0.0238
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0234
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0234
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0226
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0226
723 Cytosolic phospholipase A2 PLA2G4A 0.0224
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0222
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0221
885 5-hydroxytryptamine 1B receptor HTR1B 0.0217
24 Thymidylate synthase TMP1 0.0214
359 Thymidylate synthase TYMS 0.0214
2626 Thymidylate synthase thyA 0.0214
2729 Thymidylate synthase thyA 0.0214
5352 Thymidylate synthase THYA 0.0214
56 Delta-aminolevulinic acid dehydratase ALAD 0.0209
2356 Delta-aminolevulinic acid dehydratase hemB 0.0209
3613 Delta-aminolevulinic acid dehydratase hemB 0.0209
3674 Delta-aminolevulinic acid dehydratase hemB 0.0209
468 Cytochrome P450 4A11 CYP4A11 0.02
6141 Sodium/bile acid cotransporter SLC10A1 0.02
2286 Isocitrate dehydrogenase [NADP] icd 0.0198
2302 Isocitrate dehydrogenase [NADP] icd 0.0198
2771 Isocitrate dehydrogenase [NADP] icd 0.0198
3939 Amine oxidase [flavin-containing] B MAOB 0.0195
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0192
844 Epidermal growth factor receptor EGFR 0.0192
122 P2Y purinoceptor 12 P2RY12 0.019
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.019
4534 Cytohesin-2 CYTH2 0.0188
504 Mast/stem cell growth factor receptor KIT 0.0188
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0185
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
3668 Maltose-binding periplasmic protein precursor malE 0.0182
811 Translocator protein TSPO 0.0181
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0181
725 5-hydroxytryptamine 1D receptor HTR1D 0.0179
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0177
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0177
891 Dihydropteroate synthase folP 0.0171
5359 Dihydropteroate synthase folP 0.0171
7175 Dihydropteroate synthase sulI 0.0171
70 Type-1 angiotensin II receptor AGTR1 0.017
432 D(4) dopamine receptor DRD4 0.017
1024 Solute carrier family 22 member 11 SLC22A11 0.0167
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0165
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0165
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0164
2592 Beta-galactosidase lacZ 0.0163
756 Sex hormone-binding globulin SHBG 0.0161
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0161
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.016
315 Arginase-1 ARG1 0.0158
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0154
29 Tubulin beta-1 chain TUBB1 0.0153
952 Dipeptidyl peptidase 4 DPP4 0.0148
407 Vascular endothelial growth factor receptor 2 KDR 0.0148
6137 Multidrug resistance-associated protein 6 ABCC6 0.0147
6136 Multidrug resistance-associated protein 5 ABCC5 0.0146
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
436 5-hydroxytryptamine 2B receptor HTR2B 0.0146
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0145
4120 NADPH--cytochrome P450 reductase POR 0.0144
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0138
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0137
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0137
161 Tubulin beta chain TUBB 0.0137
312 Tubulin beta chain TUB2 0.0137
474 Acetylcholinesterase ACHE 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0137
228 Beta platelet-derived growth factor receptor PDGFRB 0.0136
26 Vascular endothelial growth factor receptor 3 FLT4 0.0136
94 5-hydroxytryptamine 4 receptor HTR4 0.0134
705 Glutamate receptor 1 GRIA1 0.0134
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0133
716 5-hydroxytryptamine 7 receptor HTR7 0.0132
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0131
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.013
32 Vascular endothelial growth factor receptor 1 FLT1 0.013
124 Histamine H2 receptor HRH2 0.0129
869 Estrogen receptor beta ESR2 0.0128
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0126
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0126
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0126
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0126
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
6020 Aldehyde oxidase AOX1 0.0123
818 50S ribosomal protein L10 rplJ 0.0122
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0122
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0121
950 Alpha platelet-derived growth factor receptor PDGFRA 0.012
777 Tumor necrosis factor TNF 0.012
1010 Cytochrome P450 51A1 CYP51A1 0.012
6102 Arylamine N-acetyltransferase 2 NAT2 0.012
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0119
2795 Methionine aminopeptidase 2 METAP2 0.0117
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0117
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0116
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0115
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0115
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0115
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0115
427 Substance-P receptor TACR1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0114
768 FK506-binding protein 1A FKBP1A 0.0112
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.011
477 DNA topoisomerase 4 subunit A parC 0.0109
886 DNA topoisomerase 4 subunit A parC 0.0109
6226 DNA topoisomerase 4 subunit A parC 0.0109
365 Dihydrofolate reductase DHFR 0.0109
2381 Dihydrofolate reductase DFR1 0.0109
2833 Dihydrofolate reductase Not Available 0.0109
2931 Dihydrofolate reductase folA 0.0109
3544 Dihydrofolate reductase folA 0.0109
3682 Dihydrofolate reductase folA 0.0109
6642 Dihydrofolate reductase folA 0.0109
6756 Dihydrofolate reductase dfrA 0.0109
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
1656 CYP2B protein CYP2B 0.0108
404 DNA gyrase subunit A gyrA 0.0108
6224 DNA gyrase subunit A gyrA 0.0108
163 D(1B) dopamine receptor DRD5 0.0104
5682 Ribonuclease pancreatic RNASE1 0.0104
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0104
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0103
1192 Sulfotransferase 1A1 SULT1A1 0.0103
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0103
592 Carbonic anhydrase 4 CA4 0.0103
1757 Myeloperoxidase MPO 0.0103
6085 Fatty acid-binding protein, intestinal FABP2 0.0102
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0102
1256 5-hydroxytryptamine 6 receptor HTR6 0.0101
738 Monocarboxylate transporter 1 SLC16A1 0.0101
1262 Corticotropin-lipotropin POMC 0.0099
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0099
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
4203 Histamine N-methyltransferase HNMT 0.0096
4237 50S ribosomal protein L22 rplV 0.0095
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0094
165 FL cytokine receptor FLT3 0.0091
1852 Microtubule-associated protein 2 MAP2 0.0091
2539 Tubulin alpha-1 chain TUBA4A 0.009
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0088
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0087
1050 Bile salt sulfotransferase SULT2A1 0.0087
131 Synaptic vesicular amine transporter SLC18A2 0.0086
528 5-hydroxytryptamine 1E receptor HTR1E 0.0085
1178 Adenosine A2a receptor ADORA2A 0.0085
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0085
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0084
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0083
373 Transthyretin TTR 0.0083
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0083
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
814 Ryanodine receptor 1 RYR1 0.0083
6126 Carbonic anhydrase 7 CA7 0.0083
469 Annexin A1 ANXA1 0.0082
362 Melatonin receptor type 1B MTNR1B 0.0081
571 Melatonin receptor type 1A MTNR1A 0.0081
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0079
319 Opioid receptor, sigma 1 OPRS1 0.0078
88 Retinoic acid receptor RXR-beta RXRB 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
357 Carbonic anhydrase 2 CA2 0.0077
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
273 Apoptosis regulator Bcl-2 BCL2 0.0076
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0075
5300 Antigen peptide transporter 1 TAP1 0.0075
1541 Metalloproteinase mmp20 0.0074
239 Coagulation factor X F10 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
6014 Cytochrome P450 2A13 CYP2A13 0.0073
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0071
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.0071
54 Prothrombin F2 0.0071
275 Arachidonate 5-lipoxygenase ALOX5 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.007
1629 Transcription factor AP-1 JUN 0.007
3810 Catechol O-methyltransferase COMT 0.007
49 Endothelin B receptor EDNRB 0.0069
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0069
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0069
3086 Plasmepsin-2 Not Available 0.0068
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0067
1196 Complement decay-accelerating factor CD55 0.0067
4122 Histone deacetylase 2 HDAC2 0.0067
6138 Multidrug resistance protein 3 ABCB4 0.0067
84 Nuclear receptor 0B1 NR0B1 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
174 Sigma 1-type opioid receptor SIGMAR1 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
1618 High affinity nerve growth factor receptor NTRK1 0.0064
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0064
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0064
2616 Ganglioside GM2 activator GM2A 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
3932 Glutathione S-transferase A2 GSTA2 0.0062
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
4773 Deoxycytidine kinase DCK 0.0062
823 Fibroblast growth factor receptor 2 FGFR2 0.0062
780 Retinoic acid receptor RXR-gamma RXRG 0.0062
3830 Calreticulin CALR 0.0061
185 Vasopressin V1a receptor AVPR1A 0.006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0059
1483 Membrane copper amine oxidase AOC3 0.0059
6134 Sodium channel subunit beta-3 SCN3B 0.0058
6132 Sodium channel subunit beta-1 SCN1B 0.0058
6135 Sodium channel subunit beta-4 SCN4B 0.0058
6129 Carbonic anhydrase-related protein 11 CA11 0.0058
6133 Sodium channel subunit beta-2 SCN2B 0.0058
6127 Carbonic anhydrase-related protein CA8 0.0058
6128 Carbonic anhydrase-related protein 10 CA10 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
2808 Chloramphenicol acetyltransferase 3 cat3 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0058
1630 Integrin beta-2 ITGB2 0.0058
6174 50S ribosomal protein L32 rpmF 0.0058
1517 Beta-3 adrenergic receptor ADRB3 0.0058
976 Platelet glycoprotein IX GP9 0.0058
6035 Nuclear receptor ROR-beta RORB 0.0057
6034 Hydroxyindole O-methyltransferase ASMT 0.0057
6036 Eosinophil peroxidase EPX 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0056
68 Cannabinoid receptor 1 CNR1 0.0055
153 Dopamine beta-hydroxylase DBH 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0055
6506 Stathmin-4 STMN4 0.0055
6131 Carbonic anhydrase 14 CA14 0.0055
1275 Estrogen sulfotransferase SULT1E1 0.0054
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0054
856 Vitamin D3 receptor VDR 0.0054
3601 Dihydropteroate synthase 1 folP1 0.0053
3807 Dihydropteroate synthase 1 folP1 0.0053
3808 Dihydropteroate synthase 2 folP2 0.0053
2417 Chloramphenicol acetyltransferase cat 0.0053
3278 Chloramphenicol acetyltransferase cat 0.0053
4311 tRNA TRDMT1 0.0053
4325 tRNA trmD 0.0053
4328 tRNA trmD 0.0053
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0053
284 DNA-directed RNA polymerase beta chain rpoB 0.0053
5773 DNA-directed RNA polymerase beta chain rpoB 0.0053
162 Retinoic acid receptor gamma-1 RARG 0.0052
3809 Estrogen-related receptor gamma ESRRG 0.0052
2810 Dr hemagglutinin structural subunit draA 0.0052
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0052
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0051
6122 Carbonic anhydrase 3 CA3 0.0051
6130 Carbonic anhydrase 13 CA13 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4103 Proteasome subunit beta type 2 PSMB2 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
4102 Proteasome subunit beta type 5 PSMB5 0.005
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.005
4101 Proteasome subunit beta type 1 PSMB1 0.005
765 Indoleamine 2,3-dioxygenase IDO1 0.005
173 Toll-like receptor 7 TLR7 0.0049
921 Glutamate receptor 2 GRIA2 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6044 Serum paraoxonase/lactonase 3 PON3 0.0047
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0047
5787 Angiopoietin-1 receptor TEK 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
518 Peroxidase/catalase T katG 0.0045
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
904 Glutathione S-transferase P GSTP1 0.0044
4210 Toll-like receptor 4 TLR4 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0044
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0044
572 Integrin alpha-L ITGAL 0.0044
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0043
183 Vascular endothelial growth factor A VEGFA 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
3913 Glutamic acid decarboxylase GAD65 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
4205 Carbonic anhydrase 9 CA9 0.0041
3007 Carbonic anhydrase 12 CA12 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0039
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0039
6432 Transporter snf 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0039
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0038
5934 Cytochrome P450 26A1 CYP26A1 0.0038
719 Retinoic acid receptor responder protein 1 RARRES1 0.0038
770 Retinoic acid-induced protein 3 GPRC5A 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0037
6043 Putative G-protein coupled receptor 44 GPR44 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
4192 DNA topoisomerase 2-beta TOP2B 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
558 Solute carrier family 12 member 1 SLC12A1 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0036
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0036
7 Nitric oxide synthase, inducible NOS2 0.0036
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0035
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0035
3904 Alanine aminotransferase 2 GPT2 0.0035
735 Alanine aminotransferase 1 GPT 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
164 Histamine H4 receptor HRH4 0.0035
1864 RET proto-oncogene RET 0.0035
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0035
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0035
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
6755 Poliovirus receptor PVR 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0034
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0033
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
267 Plasminogen activator inhibitor 1 SERPINE1 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0033
5880 Thrombopoietin receptor MPL 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6146 High affinity copper uptake protein 1 SLC31A1 0.0032
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
511 5-hydroxytryptamine 1F receptor HTR1F 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
33 Cystine/glutamate transporter SLC7A11 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0029
1992 Vitamin D-binding protein GC 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
605 Fumarate reductase flavoprotein subunit frdA 0.0027
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0027
3673 Fumarate reductase flavoprotein subunit fccA 0.0027
4912 Fumarate reductase flavoprotein subunit ifcA 0.0027
6549 Fumarate reductase flavoprotein subunit frdA 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
563 Thyroid peroxidase TPO 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3957 Adenosine deaminase ADA 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
1374 Natriuretic peptides B NPPB 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
489 Monocarboxylate transporter 2 SLC16A7 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5798 Mitogen-activated protein kinase 11 MAPK11 0.0021
2207 Rhodopsin RHO 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
2320 Thymidine kinase, cytosolic TK1 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
6459 Glycodelin PAEP 0.002
1039 Histone deacetylase 9 HDAC9 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
5961 Insulin INS 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6316 ADP-ribosylation factor 1 ARF1 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
2021 Thrombomodulin THBD 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6218 Pannexin-1 PANX1 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0016
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0016
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0016
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0016
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0016
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
291 Nitric-oxide synthase, endothelial NOS3 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0014
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0013
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
694 Matrix protein 2 M 0.0012
444 Alcohol dehydrogenase 1B ADH1B 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
3221 Cytochrome c4 cc4 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
1867 Major prion protein PRNP 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
693 Hemoglobin subunit beta HBB 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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