DT-Web

Beta-galactosidase


Partner ID 2592
Name Beta-galactosidase
Synonyms 395
Gene name lacZ
General function Carbohydrate transport and metabolism
Specific function Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides
Gene sequence + ...

ATGACCATGATTACGGATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAATGGCGAATGGCGCTTTGCCTGGTTTCCGGCACCAGAAGCGGTGCCGGAAAGCTGGCTGGAGTGCGATCTTCCTGAGGCCGATACTGTCGTCGTCCCCTCAAACTGGCAGATGCACGGTTACGATGCGCCCATCTACACCAACGTAACCTATCCCATTACGGTCAATCCGCCGTTTGTTCCCACGGAGAATCCGACGGGTTGTTACTCGCTCACATTTAATGTTGATGAAAGCTGGCTACAGGAAGGCCAGACGCGAATTATTTTTGATGGCGTTAACTCGGCGTTTCATCTGTGGTGCAACGGGCGCTGGGTCGGTTACGGCCAGGACAGTCGTTTGCCGTCTGAATTTGACCTGAGCGCATTTTTACGCGCCGGAGAAAACCGCCTCGCGGTGATGGTGCTGCGTTGGAGTGACGGCAGTTATCTGGAAGATCAGGATATGTGGCGGATGAGCGGCATTTTCCGTGACGTCTCGTTGCTGCATAAACCGACTACACAAATCAGCGATTTCCATGTTGCCACTCGCTTTAATGATGATTTCAGCCGCGCTGTACTGGAGGCTGAAGTTCAGATGTGCGGCGAGTTGCGTGACTACCTACGGGTAACAGTTTCTTTATGGCAGGGTGAAACGCAGGTCGCCAGCGGCACCGCGCCTTTCGGCGGTGAAATTATCGATGAGCGTGGTGGTTATGCCGATCGCGTCACACTACGTCTGAACGTCGAAAACCCGAAACTGTGGAGCGCCGAAATCCCGAATCTCTATCGTGCGGTGGTTGAACTGCACACCGCCGACGGCACGCTGATTGAAGCAGAAGCCTGCGATGTCGGTTTCCGCGAGGTGCGGATTGAAAATGGTCTGCTGCTGCTGAACGGCAAGCCGTTGCTGATTCGAGGCGTTAACCGTCACGAGCATCATCCTCTGCATGGTCAGGTCATGGATGAGCAGACGATGGTGCAGGATATCCTGCTGATGAAGCAGAACAACTTTAACGCCGTGCGCTGTTCGCATTATCCGAACCATCCGCTGTGGTACACGCTGTGCGACCGCTACGGCCTGTATGTGGTGGATGAAGCCAATATTGAAACCCACGGCATGGTGCCAATGAATCGTCTGACCGATGATCCGCGCTGGCTACCGGCGATGAGCGAACGCGTAACGCGAATGGTGCAGCGCGATCGTAATCACCCGAGTGTGATCATCTGGTCGCTGGGGAATGAATCAGGCCACGGCGCTAATCACGACGCGCTGTATCGCTGGATCAAATCTGTCGATCCTTCCCGCCCGGTGCAGTATGAAGGCGGCGGAGCCGACACCACGGCCACCGATATTATTTGCCCGATGTACGCGCGCGTGGATGAAGACCAGCCCTTCCCGGCTGTGCCGAAATGGTCCATCAAAAAATGGCTTTCGCTACCTGGAGAGACGCGCCCGCTGATCCTTTGCGAATACGCCCACGCGATGGGTAACAGTCTTGGCGGTTTCGCTAAATACTGGCAGGCGTTTCGTCAGTATCCCCGTTTACAGGGCGGCTTCGTCTGGGACTGGGTGGATCAGTCGCTGATTAAATATGATGAAAACGGCAACCCGTGGTCGGCTTACGGCGGTGATTTTGGCGATACGCCGAACGATCGCCAGTTCTGTATGAACGGTCTGGTCTTTGCCGACCGCACGCCGCATCCAGCGCTGACGGAAGCAAAACACCAGCAGCAGTTTTTCCAGTTCCGTTTATCCGGGCAAACCATCGAAGTGACCAGCGAATACCTGTTCCGTCATAGCGATAACGAGCTCCTGCACTGGATGGTGGCGCTGGATGGTAAGCCGCTGGCAAGCGGTGAAGTGCCTCTGGATGTCGCTCCACAAGGTAAACAGTTGATTGAACTGCCTGAACTACCGCAGCCGGAGAGCGCCGGGCAACTCTGGCTCACAGTACGCGTAGTGCAACCGAACGCGACCGCATGGTCAGAAGCCGGGCACATCAGCGCCTGGCAGCAGTGGCGTCTGGCGGAAAACCTCAGTGTGACGCTCCCCGCCGCGTCCCACGCCATCCCGCATCTGACCACCAGCGAAATGGATTTTTGCATCGAGCTGGGTAATAAGCGTTGGCAATTTAACCGCCAGTCAGGCTTTCTTTCACAGATGTGGATTGGCGATAAAAAACAACTGCTGACGCCGCTGCGCGATCAGTTCACCCGTGCACCGCTGGATAACGACATTGGCGTAAGTGAAGCGACCCGCATTGACCCTAACGCCTGGGTCGAACGCTGGAAGGCGGCGGGCCATTACCAGGCCGAAGCAGCGTTGTTGCAGTGCACGGCAGATACACTTGCTGATGCGGTGCTGATTACGACCGCTCACGCGTGGCAGCATCAGGGGAAAACCTTATTTATCAGCCGGAAAACCTACCGGATTGATGGTAGTGGTCAAATGGCGATTACCGTTGATGTTGAAGTGGCGAGCGATACACCGCATCCGGCGCGGATTGGCCTGAACTGCCAGCTGGCGCAGGTAGCAGAGCGGGTAAACTGGCTCGGATTAGGGCCGCAAGAAAACTATCCCGACCGCCTTACTGCCGCCTGTTTTGACCGCTGGGATCTGCCATTGTCAGACATGTATACCCCGTACGTCTTCCCGAGCGAAAACGGTCTGCGCTGCGGGACGCGCGAATTGAATTATGGCCCACACCAGTGGCGCGGCGACTTCCAGTTCAACATCAGCCGCTACAGTCAACAGCAACTGATGGAAACCAGCCATCGCCATCTGCTGCACGCGGAAGAAGGCACATGGCTGAATATCGACGGTTTCCATATGGGGATTGGTGGCGACGACTCCTGGAGCCCGTCAGTATCGGCGGAATTCCAGCTGAGCGCCGGTCGCTACCATTACCAGTTGGTCTGGTGTCAAAAATAA
Protein sequence + ...

MTMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRDYLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGFREVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELLHWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAGQLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPAASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMWIGDKKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVAERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGRYHYQLVWCQK
GO Classification
component
unlocalized protein complex
beta-galactosidase complex
protein complex
function
hydrolase activity, hydrolyzing O-glycosyl compounds
galactosidase activity
beta-galactosidase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
process
physiological process
metabolism
macromolecule metabolism
carbohydrate metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01862 1-(Isopropylthio)-Beta-Galactopyranside
DB01885 D-Galctopyranosyl-1-On
DB01920 1-O-[O-Nitrophenyl]-Beta-D-Galactopyranose
DB02228 2-Fluoro-2-Deoxy-Beta-D-Galactopyranose
DB02294 (5r,6s,7s,8s)-5-Hydroxymethyl-6,7,8-Trihydroxy-Tetrazolo[1,5-a]Piperidine
DB02632 1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose
DB04116 Allolactose
DB04155 2-Fluoro-2-Deoxy-Beta-D-Galactopyranosyl-Beta-D-Glucopyranose
DB04382 2-Deoxy-Beta-D-Galactose
DB04465 Lactose
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine

Associated as Prediction

Id Name
DB00129 L-Ornithine
DB00131 Adenosine monophosphate
DB00201 Caffeine
DB00277 Theophylline
DB00293 Raltitrexed
DB00322 Floxuridine
DB00432 Trifluridine
DB00440 Trimethoprim
DB00441 Gemcitabine
DB00544 Fluorouracil
DB00563 Methotrexate
DB00622 Nicardipine
DB00642 Pemetrexed
DB00650 Leucovorin
DB00651 Dyphylline
DB00806 Pentoxifylline
DB00824 Enprofylline
DB00920 Ketotifen
DB01023 Felodipine
DB01088 Iloprost
DB01101 Capecitabine
DB01113 Papaverine
DB01244 Bepridil
DB01412 Theobromine
DB01427 Amrinone
DB01643 Thymidine-5'-Phosphate
DB01647 (R)-Mesopram
DB01656 Roflumilast
DB01754 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One
DB01791 Piclamilast
DB01862 1-(Isopropylthio)-Beta-Galactopyranside
DB01863 Inositol 1,3,4,5-Tetrakisphosphate
DB01885 D-Galctopyranosyl-1-On
DB01894 5-N-Acetyl-Alpha-D-Neuraminic Acid
DB01914 D-Glucose in Linear Form
DB01919 Pentanal
DB01920 1-O-[O-Nitrophenyl]-Beta-D-Galactopyranose
DB01940 Balanol Analog 2
DB01942 Formic Acid
DB01954 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone
DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
DB01983 2(S)-Amino-6-Boronohexanoic Acid
DB01992 Coenzyme A
DB02010 Staurosporine
DB02031 (6s)-5,6,7,8-Tetrahydrofolate
DB02155 Balanol Analog 8
DB02159 R-1,2-Propanediol
DB02223 Ly231514 Tetra Glu
DB02228 2-Fluoro-2-Deoxy-Beta-D-Galactopyranose
DB02256 2'-Deoxyuridine
DB02260 4-Oxosebacic Acid
DB02265 Ethyl-Trimethyl-Silane
DB02294 (5r,6s,7s,8s)-5-Hydroxymethyl-6,7,8-Trihydroxy-Tetrazolo[1,5-a]Piperidine
DB02301 5,10-Methylene-6-Hydrofolic Acid
DB02379 Beta-D-Glucose
DB02381 Nor-N-Omega-Hydroxy-L-Arginine
DB02440 N-Octane
DB02467 S-Oxymethionine
DB02482 Phosphonothreonine
DB02499 Dinor-N(Omega)-Hydroxy-L-Arginine
DB02611 Balanol Analog 1
DB02632 1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose
DB02656 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One
DB02660 Filaminast
DB02689 S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine
DB02752 Tosyl-D-Proline
DB02764 Hexane
DB02899 N-Carboxymethionine
DB03038 LY341770
DB03144 N-Omega-Hydroxy-L-Arginine
DB03157 N,O-Didansyl-L-Tyrosine
DB03203 Sphingosine
DB03274 2'-5'dideoxyuridine
DB03323 Maltose
DB03349 8-Bromo-Adenosine-5'-Monophosphate
DB03374 3,5-Diiodotyrosine
DB03389 alpha-D-Xylopyranose
DB03401 D-Myo-Inositol-1,4,5-Triphosphate
DB03541 10-Propargyl-5,8-Dideazafolic Acid
DB03558 Sp-876
DB03600 Decanoic Acid
DB03606 (S)-Rolipram
DB03650 (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One
DB03721 O-Sialic Acid
DB03731 S-2-(Boronoethyl)-L-Cysteine
DB03761 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
DB03777 Rbt205 Inhibitor
DB03800 2'-deoxyuridylic acid
DB03807 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
DB03818 N-[Tosyl-D-Prolinyl]Amino-Ethanethiol
DB03849 Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid
DB03904 Urea
DB03991 2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid
DB03995 Cyclo-Hepta-Amylose
DB04098 Balanol
DB04116 Allolactose
DB04149 (R)-Rolipram
DB04155 2-Fluoro-2-Deoxy-Beta-D-Galactopyranosyl-Beta-D-Glucopyranose
DB04197 Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine
DB04216 Quercetin
DB04224 Oleic Acid
DB04265 Beta-Sialic Acid
DB04272 Citric Acid
DB04349 S-1,2-Propanediol
DB04382 2-Deoxy-Beta-D-Galactose
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04447 1,4-Dithiothreitol
DB04457 2'-Deoxyguanosine-5'-Monophosphate
DB04465 Lactose
DB04503 Sp-722
DB04522 Phosphonoserine
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04560 4,7-Dioxosebacic Acid
DB04585 DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID
DB04586 2-bromophenol
DB04648 S-propylamine-L-cysteine
DB04696 4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN
DB04707 HYDROXYFASUDIL
DB04715 IMIDAZOPYRIDAZIN 1
DB05266 Ibudilast
DB06813 Pralatrexate
DB06909 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
DB06959 (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE
DB06977 (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE
DB07107 (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
DB07124 (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
DB07151 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one
DB07204 (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
DB07235 N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
DB07348 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE
DB07458 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE
DB07524 N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine
DB07577 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE
DB07583 (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
DB07854 N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
DB07855 (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
DB07856 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
DB07857 (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
DB07858 (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
DB07860 (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
DB07876 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
DB07995 N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
DB07996 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
DB07997 N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
DB08022 (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile
DB08070 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
DB08113 3-pyridin-4-yl-1H-indazole
DB08114 5-benzyl-1,3-thiazol-2-amine
DB08131 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-3-METHYL-BUTYRIC ACID
DB08148 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
DB08149 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
DB08150 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
DB08162 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
DB08166 (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
DB08227 1-(1-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL)PYRROLIDINE-2,5-DIONE
DB08230 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE
DB08231 MYRISTIC ACID
DB08297 ORTHONITROPHENYL-BETA-D-FUCOPYRANOSIDE
DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
DB08478 N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide
DB08479 N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide
DB08568 (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE
DB08569 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
DB08705 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE
DB08707 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine
DB08708 N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine
DB08709 2,3-diphenyl-1H-indole-7-carboxylic acid
DB08734 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE
DB08756 (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
DB08846 Ellagic Acid
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